GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000350
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Drosophila melanogaster - sitter allele - slow locomotion
Trait State in Taxon B
Drosophila melanogaster - rover allele - increased larval locomotion - larvae more active - Adults carrying the R allele walk farther from food source after feeding than do adults with the S strain.
Ancestral State
Unknown
Taxonomic Status
Taxon A
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
for
Synonyms
142251_at; anon-WO0140519.260; anon-WO02059370.47; BcDNA:GM08338; CG10033; dg2; Dg2; DG2; Dmel\CG10033; For; FOR/PKG; l(2)06860; PKG; Pkg2; PKG2; Pkg24A; PGK2
String
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
GO - Molecular Function
GO:0005524 : ATP binding
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GO - Biological Process
GO:0007616 : long-term memory
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GO - Cellular Component
GO:0005886 : plasma membrane
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Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
The fors (sitter) and forR (rover) alleles differ in a SNP that lies within a predicted Mad protein-binding site in a region upstream of the pr4 transcription start site. The SNP is a C in fors and an A in forR (the latter is predicted to reduce Mad protein binding).
Experimental Evidence
Main Reference
Authors
Osborne KA; Robichon A; Burgess E; Butland S; Shaw RA; Coulthard A; Pereira HS; Greenspan RJ; et al.
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Abstract
Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
http://flybase.org/reports/FBal0004143 - http://flybase.org/reports/FBal0004144
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