GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000385
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Kluyveromyces lactis
Trait State in Taxon B
Saccharomyces cerevisiae
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
Kluyveromyces drosophilarum; Kluyveromyces lactis var. drosophilarum; Kluyveromyces lactis var. lactis; Kluyveromyces marxianus lactis; Kluyveromyces marxianus var. drosophilarum; Kluyveromyces marxianus var. lactis; ATCC 56498; ATCC:56498; CBS 2105; CBS 683; CBS:2105; CBS:683; NRRL Y-8278; NRRL Y-8279; NRRL:Y:8278; NRRL:Y:8279
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
baker's yeast
Synonyms
Saccharomyces capensis; Saccharomyces italicus; Saccharomyces oviformis; Saccharomyces uvarum var. melibiosus; baker's yeast; S. cerevisiae; brewer's yeast; ATCC 18824; ATCC:18824; CBS 1171; CBS:1171; NRRL Y-12632; NRRL:Y:12632; Saccaromyces cerevisiae; Saccharomyce cerevisiae; Saccharomyes cerevisiae; Sccharomyces cerevisiae
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
GAL1
Synonyms
KLLA0F08393g
String
Sequence Similarities
Belongs to the GHMP kinase family. GalK subfamily.
GO - Molecular Function
GO:0005524 : ATP binding
... show more
GO - Biological Process
GO - Cellular Component
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Helical phasing of GAL4 elements in promoter region following duplication
Experimental Evidence
Authors
Hittinger CT; Carroll SB
Abstract
How gene duplication and divergence contribute to genetic novelty and adaptation has been of intense interest, but experimental evidence has been limited. The genetic switch controlling the yeast galactose use pathway includes two paralogous genes in Saccharomyces cerevisiae that encode a co-inducer (GAL3) and a galactokinase (GAL1). These paralogues arose from a single bifunctional ancestral gene as is still present in Kluyveromyces lactis. To determine which evolutionary processes shaped the evolution of the two paralogues, here we assess the effects of precise replacement of coding and non-coding sequences on organismal fitness. We suggest that duplication of the ancestral bifunctional gene allowed for the resolution of an adaptive conflict between the transcriptional regulation of the two gene functions. After duplication, previously disfavoured binding site configurations evolved that divided the regulation of the ancestral gene into two specialized genes, one of which ultimately became one of the most tightly regulated genes in the genome.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Duplication
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