GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000405
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Hominoids
Trait State in Taxon B
other mammals
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
mammals
Synonyms
mammals
Rank
class
Lineage
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Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
great apes
Synonyms
Pongidae; great apes; Hominidae Gray, 1825
Rank
family
Lineage
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leostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
GLUD2
Synonyms
GDH2; GLUDP1
String
Sequence Similarities
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
GO - Molecular Function
GO:0043531 : ADP binding
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GO - Biological Process
GO:0055114 : oxidation-reduction process
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GO - Cellular Component
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Retroduplication; + E7K enhancing mitochondrial targeting
Experimental Evidence
Main Reference
Authors
Burki F; Kaessmann H
Abstract
The enzyme glutamate dehydrogenase (GDH) is important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Human GDH exists in housekeeping and brain-specific isotypes encoded by the genes GLUD1 and GLUD2, respectively. Here we show that GLUD2 originated by retroposition from GLUD1 in the hominoid ancestor less than 23 million years ago. The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event.
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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