GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00000428
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Helicoverpa armigera - Bt-Cry1Ac susceptible
Trait State in Taxon B
Helicoverpa armigera - Bt-Cry1Ac resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
cotton bollworm
Synonyms
Heliothis (Helicoverpa) armigera; Heliothis armigera; cotton bollworm; American bollworm; corn ear worm; scarce bordered straw; tobacco budworm; Helicoverpa armigera (Hubner, 1808)
Rank
species
Lineage
Show more ... da; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Noctuoidea; Noctuidae; Heliothinae; Helicoverpa
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
cotton bollworm
Synonyms
Heliothis (Helicoverpa) armigera; Heliothis armigera; cotton bollworm; American bollworm; corn ear worm; scarce bordered straw; tobacco budworm; Helicoverpa armigera (Hubner, 1808)
Rank
species
Lineage
Show more ... da; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Noctuoidea; Noctuidae; Heliothinae; Helicoverpa
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
ABCA2
Synonyms
-
String
-
Sequence Similarities
-
GO - Biological Process
-
UniProtKB
Helicoverpa armigera
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
Insertion of a LTR retrotransposon
Experimental Evidence
Authors
Yang Y; Chen H; Wu S; Yang Y; Xu X; Wu Y
Abstract
Cadherins are a class of receptor proteins for Bacillus thuringiensis Cry1A toxins. Disruption of a cadherin gene (Ha_BtR) is associated with Cry1Ac resistance in the cotton bollworm Helicoverpa armigera [Xu, X., Yu, L., Wu, Y., 2005. Disruption of a cadherin gene associated with resistance to Cry1Ac delta-endotoxin of B. thuringiensis in H. armigera. Appl. Environ. Microbiol. 71, 948-954]. Determination of the genomic DNA sequences of Ha_BtR gene showed that the wild type Ha_BtR coding sequence is comprised of 34 exons. A deletion between Exon 8 and Exon 25 was found to be responsible for a truncated cadherin in the Cry1Ac-resistant GYBT strain of H. armigera. The mutant allele of Ha_BtR (r1) has two possible transcription variants, both of which produce the same truncated protein. A DNA-based detection method specific to the r1 allele was developed. This study will facilitate the monitoring of cadherin mutant frequency in field populations of H. armigera.
RELATED GEPHE
Related Haplotypes
7
COMMENTS
@TE Parallelism: repeated loss-of-function
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