GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00000463
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Lophonetta specularioides- low-altitude
Trait State in Taxon B
Lophonetta specularioides- High-altitude
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
crested duck
Synonyms
Anas specularioides; Lophonetta specularoides; crested duck; Lophonetta specularioides (King, 1828)
Rank
species
Lineage
Show more ... rpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; Anatinae; Lophonetta
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
crested duck
Synonyms
Anas specularioides; Lophonetta specularoides; crested duck; Lophonetta specularioides (King, 1828)
Rank
species
Lineage
Show more ... rpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; Anatinae; Lophonetta
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Ala5Thr
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
McCracken KG; Barger CP; Bulgarella M; Johnson KP; Sonsthagen SA; Trucco J; Valqui TH; Wilson RE; et al. ... show more
Abstract
Theory predicts that parallel evolution should be common when the number of beneficial mutations is limited by selective constraints on protein structure. However, confirmation is scarce in natural populations. Here we studied the major haemoglobin genes of eight Andean duck lineages and compared them to 115 other waterfowl species, including the bar-headed goose (Anser indicus) and Abyssinian blue-winged goose (Cyanochen cyanopterus), two additional species living at high altitude. One to five amino acid replacements were significantly overrepresented or derived in each highland population, and parallel substitutions were more common than in simulated sequences evolved under a neutral model. Two substitutions evolved in parallel in the alpha A subunit of two (Ala-alpha 8) and five (Thr-alpha 77) taxa, and five identical beta A subunit substitutions were observed in two (Ser-beta 4, Glu-beta 94, Met-beta 133) or three (Ser-beta 13, Ser-beta 116) taxa. Substitutions at adjacent sites within the same functional protein region were also observed. Five such replacements were in exterior, solvent-accessible positions on the A helix and AB corner of the alpha A subunit. Five others were in close proximity to inositolpentaphosphate binding sites, and two pairs of independent replacements occurred at two different alpha(1)beta(1) intersubunit contacts. More than half of the substitutions in highland lineages resulted in the acquisition of serine or threonine (18 gains vs. 2 losses), both of which possess a hydroxyl group that can hydrogen bond to a variety of polar substrates. The patterns of parallel evolution observed in these waterfowl suggest that adaptation to high-altitude hypoxia has resulted from selection on unique but overlapping sets of one to five amino acid substitutions in each lineage.
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
Needs curation
YOUR FEEDBACK is welcome!