GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000544
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
C. briggsae; C. remanei; C. japonica; C. sp CB5161
Trait State in Taxon B
C. elegans
Ancestral State
Taxon A
Taxonomic Status
Taxon A #1
Latin Name
Common Name
-
Synonyms
Caenorhabditis briggsae Dougherty & Nigon, 1949
Rank
species
Lineage
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s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon A #2
Latin Name
Common Name
-
Synonyms
Caenorhabditis vulgaris; Caenorhabditis remanei (Sudhaus, 1974); Caenorhabditis vulgaris Baird, Fitch & Emmons, 1994; Caenorhabditis vulgarensis; Caenorhabditis vulgariensis
Rank
species
Lineage
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s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon A #3
Latin Name
Common Name
-
Synonyms
-
Rank
species
Lineage
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s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
roundworm; Rhabditis elegans; Caenorhabditis elegans (Maupas, 1900); Rhabditis elegans Maupas, 1900
Rank
species
Lineage
Show more ...
s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
lin-48
Synonyms
CELE_F34D10.5; F34D10.5
String
Sequence Similarities
-
GO - Molecular Function
GO - Biological Process
GO:0006355 : regulation of transcription, DNA-templated
... show more
GO - Cellular Component
Mutation #1
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Exact mutations unknown - region 1 of 4 regions identified based on chimeric constructs
Experimental Evidence
Main Reference
Authors
Wang X; Chamberlin HM
Abstract
Recent work points to the importance of changes in gene expression patterns in species-specific differences. Here, we investigate the evolution of the nematode lin-48 ovo gene. lin-48 is expressed in several cells in both Caenorhabditis elegans and Caenorhabditis briggsae, but acts in the excretory duct cell only in C. elegans. We find the differences result both from alterations in the cis-regulatory sequences and in proteins that mediate lin-48 expression. One factor that contributes to the species differences is the bZip protein CES-2. Our results indicate the accumulation of several regulatory changes affecting one gene can contribute to evolutionary change.
Additional References
Mutation #2
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Exact mutations unknown - region 2 of 4 regions identified based on chimeric constructs
Experimental Evidence
Main Reference
Authors
Wang X; Chamberlin HM
Abstract
Recent work points to the importance of changes in gene expression patterns in species-specific differences. Here, we investigate the evolution of the nematode lin-48 ovo gene. lin-48 is expressed in several cells in both Caenorhabditis elegans and Caenorhabditis briggsae, but acts in the excretory duct cell only in C. elegans. We find the differences result both from alterations in the cis-regulatory sequences and in proteins that mediate lin-48 expression. One factor that contributes to the species differences is the bZip protein CES-2. Our results indicate the accumulation of several regulatory changes affecting one gene can contribute to evolutionary change.
Additional References
Mutation #3
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Exact mutations unknown - region 3 of 4 regions identified based on chimeric constructs
Experimental Evidence
Main Reference
Authors
Wang X; Chamberlin HM
Abstract
Recent work points to the importance of changes in gene expression patterns in species-specific differences. Here, we investigate the evolution of the nematode lin-48 ovo gene. lin-48 is expressed in several cells in both Caenorhabditis elegans and Caenorhabditis briggsae, but acts in the excretory duct cell only in C. elegans. We find the differences result both from alterations in the cis-regulatory sequences and in proteins that mediate lin-48 expression. One factor that contributes to the species differences is the bZip protein CES-2. Our results indicate the accumulation of several regulatory changes affecting one gene can contribute to evolutionary change.
Additional References
Mutation #4
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Exact mutations unknown - region 4 of 4 regions identified based on chimeric constructs
Experimental Evidence
Main Reference
Authors
Wang X; Chamberlin HM
Abstract
Recent work points to the importance of changes in gene expression patterns in species-specific differences. Here, we investigate the evolution of the nematode lin-48 ovo gene. lin-48 is expressed in several cells in both Caenorhabditis elegans and Caenorhabditis briggsae, but acts in the excretory duct cell only in C. elegans. We find the differences result both from alterations in the cis-regulatory sequences and in proteins that mediate lin-48 expression. One factor that contributes to the species differences is the bZip protein CES-2. Our results indicate the accumulation of several regulatory changes affecting one gene can contribute to evolutionary change.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@SeveralMutationsWithEffect
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