GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000057
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Peromyscus polionotus subgriseus (mainland)
Trait State in Taxon B
Peromyscus polionotus leucocephalus (beach)
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
oldfield mouse
Synonyms
oldfield mouse
Rank
species
Lineage
Show more ... eostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Peromyscus polionotus subgriseus (mainland)
Taxon B
Common Name
oldfield mouse
Synonyms
oldfield mouse
Rank
species
Lineage
Show more ... eostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus leucocephalus (beach)
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
Not identified
Experimental Evidence
Authors
Manceau M; Domingues VS; Mallarino R; Hoekstra HE
Abstract
Animal color patterns can affect fitness in the wild; however, little is known about the mechanisms that control their formation and subsequent evolution. We took advantage of two locally camouflaged populations of Peromyscus mice to show that the negative regulator of adult pigmentation, Agouti, also plays a key developmental role in color pattern evolution. Genetic and functional analyses showed that ventral-specific embryonic expression of Agouti establishes a prepattern by delaying the terminal differentiation of ventral melanocytes. Moreover, a skin-specific increase in both the level and spatial domain of Agouti expression prevents melanocyte maturation in a regionalized manner, resulting in a novel and adaptive color pattern. Thus, natural selection favors late-acting, tissue-specific changes in embryonic Agouti expression to produce large changes in adult color pattern.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
2
COMMENTS
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