GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000057
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
mainland brown coat
Trait State in Taxon B
gulf beach and atlantic beach light coloured coats
Ancestral State
Taxon A
Taxonomic Status
Taxon A #1
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Peromyscus polionotus subgriseus (mainland dark colored coat)
Taxon A #2
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Peromyscus polionotus polionotus (mainland dark colored coat)
Taxon A #3
Common Name
-
Synonyms
Peromyscus polionotus albifrons Osgood, 1909
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Peromyscus polionotus albifrons (mainland dark colored coat)
Taxon B #1
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus leucocephalus (gulf beach)
Taxon B #2
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus niveiventris (atlantic beach)
Taxon B #3
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus peninsularis (gulf beach)
Taxon B #4
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus allophrys (gulf beach)
Taxon B #5
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus trissyllepsis (gulf beach)
Taxon B #6
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus ammobates (gulf beach)
Taxon B #7
Common Name
-
Synonyms
Peromyscus polionotus albifrons Osgood, 1909
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus albifrons (mainland light colored coat)
Taxon B #8
Common Name
-
Synonyms
-
Rank
subspecies
Lineage
Show more ... Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus; Peromyscus polionotus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus polionotus subgriseus (mainland dark colored coat)
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
"A closer investigation of this region revealed three SNPs significantly associated with pigment variation, spanning 1,756 bp, in strong linkage disequilibrium (mean r2 = 0.85). A single SNP on chromosome 4 (chr4) at position chr4: 9,845,301 showed a markedly stronger association with pPC1 than the other two (Fig. 3B). This SNP is located between two untranslated exons (exons 1D and 1E), is 120 bp upstream of a cluster of Short Interspersed Nuclear Elements (SINE) in reverse orientation relative to the transcription of Agouti, and is 5,641 bp upstream of the first coding exon (exon 2). "

"Next, we employ an association-mapping approach to identify an ∼2-kb previously uncharacterized noncoding region of Agouti associated with color variation. We then show that this 2-kb region can drive dermal expression in Mus embryos, demonstrating its regulatory activity in the skin during the establishment of pigmentation."
Experimental Evidence
Authors
Manceau M; Domingues VS; Mallarino R; Hoekstra HE
Abstract
Animal color patterns can affect fitness in the wild; however, little is known about the mechanisms that control their formation and subsequent evolution. We took advantage of two locally camouflaged populations of Peromyscus mice to show that the negative regulator of adult pigmentation, Agouti, also plays a key developmental role in color pattern evolution. Genetic and functional analyses showed that ventral-specific embryonic expression of Agouti establishes a prepattern by delaying the terminal differentiation of ventral melanocytes. Moreover, a skin-specific increase in both the level and spatial domain of Agouti expression prevents melanocyte maturation in a regionalized manner, resulting in a novel and adaptive color pattern. Thus, natural selection favors late-acting, tissue-specific changes in embryonic Agouti expression to produce large changes in adult color pattern.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@parallelism
YOUR FEEDBACK is welcome!