GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00000627
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Aspidoscelis inornata
Trait State in Taxon B
Aspidoscelis inornata
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
Little striped whiptail
Synonyms
Aspidoscelis inornata; Cnemidophorus inornatus; Little striped whiptail; Cnemidophorus inornatus Baird 1859
Rank
species
Lineage
Show more ... gii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata; Teiioidea; Teiidae; Aspidoscelis; Aspidoscelis sexlineata group
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
Little striped whiptail
Synonyms
Aspidoscelis inornata; Cnemidophorus inornatus; Little striped whiptail; Cnemidophorus inornatus Baird 1859
Rank
species
Lineage
Show more ... gii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata; Teiioidea; Teiidae; Aspidoscelis; Aspidoscelis sexlineata group
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
MC1R
Synonyms
CMM5; MSH-R; SHEP2; MSHR
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
I170T
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Rosenblum EB; Hoekstra HE; Nachman MW
Abstract
The wealth of information on the genetics of pigmentation and the clear fitness consequences of many pigmentation phenotypes provide an opportunity to study the molecular basis of an ecologically important trait. The melanocortin-1 receptor (Mc1r) is responsible for intraspecific color variation in mammals and birds. Here, we study the molecular evolution of Mc1r and investigate its role in adaptive intraspecific color differences in reptiles. We sequenced the complete Mc1r locus in seven phylogenetically diverse squamate species with melanic or blanched forms associated with different colored substrates or thermal environments. We found that patterns of amino acid substitution across different regions of the receptor are similar to the patterns seen in mammals, suggesting comparable levels of constraint and probably a conserved function for Mc1r in mammals and reptiles. We also found high levels of silent-site heterozygosity in all species, consistent with a high mutation rate or large long-term effective population size. Mc1r polymorphisms were strongly associated with color differences in Holbrookia maculata and Aspidoscelis inornata. In A. inornata, several observations suggest that Mc1r mutations may contribute to differences in color: (1) a strong association is observed between one Mc1r amino acid substitution and dorsal color; (2) no significant population structure was detected among individuals from these populations at the mitochondrial ND4 gene; (3) the distribution of allele frequencies at Mc1r deviates from neutral expectations; and (4) patterns of linkage disequilibrium at Mc1r are consistent with recent selection. This study provides comparative data on a nuclear gene in reptiles and highlights the utility of a candidate-gene approach for understanding the evolution of genes involved in vertebrate adaptation.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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