GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00000629
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Scleropus undulatus
Trait State in Taxon B
Scleropus undulatus
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
fence lizard
Synonyms
Stellio undulatus; fence lizard; Stellio undulatus Bosc & Daudin 1801
Rank
species
Lineage
Show more ... rcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Iguania; Phrynosomatidae; Phrynosomatinae; Sceloporus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
fence lizard
Synonyms
Stellio undulatus; fence lizard; Stellio undulatus Bosc & Daudin 1801
Rank
species
Lineage
Show more ... rcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Iguania; Phrynosomatidae; Phrynosomatinae; Sceloporus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
MC1R
Synonyms
CMM5; MSH-R; SHEP2; MSHR
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
H208Y
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Rosenblum EB; Römpler H; Schöneberg T; Hoekstra HE
Abstract
There are many striking examples of phenotypic convergence in nature, in some cases associated with changes in the same genes. But even mutations in the same gene may have different biochemical properties and thus different evolutionary consequences. Here we dissect the molecular mechanism of convergent evolution in three lizard species with blanched coloration on the gypsum dunes of White Sands, New Mexico. These White Sands forms have rapidly evolved cryptic coloration in the last few thousand years, presumably to avoid predation. We use cell-based assays to demonstrate that independent mutations in the same gene underlie the convergent blanched phenotypes in two of the three species. Although the same gene contributes to light phenotypes in these White Sands populations, the specific molecular mechanisms leading to reduced melanin production are different. In one case, mutations affect receptor signaling and in the other, the ability of the receptor to integrate into the melanocyte membrane. These functional differences have important ramifications at the organismal level. Derived alleles in the two species show opposite dominance patterns, which in turn affect their visibility to selection and the spatial distribution of alleles across habitats. Our results demonstrate that even when the same gene is responsible for phenotypic convergence, differences in molecular mechanism can have dramatic consequences on trait expression and ultimately the adaptive trajectory.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
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