GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000701
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Leptodactylus latrans (formerly known as Leptodactylus ocellatus) - sensitive
Trait State in Taxon B
Leptodactylus latrans (formerly known as Leptodactylus ocellatus) - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
argus frog
Synonyms
argus frog; wrestler frog
Rank
species
Lineage
Show more ... Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leptodactylinae; Leptodactylus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
argus frog
Synonyms
argus frog; wrestler frog
Rank
species
Lineage
Show more ... Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leptodactylinae; Leptodactylus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Atp1a1
Synonyms
Atpa-1; BC010319
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
UniProtKB
Mus musculus
GenebankID or UniProtKB
Mutation #1
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Q111R
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Gln Arg 111
Authors
Moore DJ; Halliday DC; Rowell DM; Robinson AJ; Keogh JS
Abstract
Members of the Family Bufonidae, true toads, are famous for their endogenously synthesized cardioactive steroids that serve as defensive toxins. Evolution of resistance to these toxins is not understood. We sequenced a key region of the toxin's binding site in the Na(+)/K(+) ATPase for relevant taxa representing Hyloidea (including bufonids), Ranoidea and Archaeobatrachia and tested for positive selection in a phylogenetic context. Bufonidae were distinct from other Hyloidea at 4-6 of 12 sites and, with one exception, had a homologous amino acid sequence. Melanophryniscus stelzneri had a distinct sequence, consistent with other independent evidence for a differentiated toxin. Tests within Bufonidae detected positive selection within the binding region, providing, to our knowledge, the first evidence of this type for positive selection within Amphibia. There was no evidence for positive selection on Bufonidae or M. stelzneri lineages. Sequence change in Leptodactylus ocellatus, a leptodactylid predator of Bufonidae, provides a molecular basis for predator resistance possibly associated with gene duplication.
Mutation #2
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
N122D
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Asn Asp 122
Authors
Moore DJ; Halliday DC; Rowell DM; Robinson AJ; Keogh JS
Abstract
Members of the Family Bufonidae, true toads, are famous for their endogenously synthesized cardioactive steroids that serve as defensive toxins. Evolution of resistance to these toxins is not understood. We sequenced a key region of the toxin's binding site in the Na(+)/K(+) ATPase for relevant taxa representing Hyloidea (including bufonids), Ranoidea and Archaeobatrachia and tested for positive selection in a phylogenetic context. Bufonidae were distinct from other Hyloidea at 4-6 of 12 sites and, with one exception, had a homologous amino acid sequence. Melanophryniscus stelzneri had a distinct sequence, consistent with other independent evidence for a differentiated toxin. Tests within Bufonidae detected positive selection within the binding region, providing, to our knowledge, the first evidence of this type for positive selection within Amphibia. There was no evidence for positive selection on Bufonidae or M. stelzneri lineages. Sequence change in Leptodactylus ocellatus, a leptodactylid predator of Bufonidae, provides a molecular basis for predator resistance possibly associated with gene duplication.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
@SeveralMutationsWithEffect - Ujvari et al. 2015 show that the change is intraspecific
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