GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000713
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Other moths
Trait State in Taxon B
Cycnia tenera
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
butterflies and moths
Synonyms
butterflies and moths; moths
Rank
order
Lineage
Show more ... hokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B #1
Latin Name
Common Name
delicate cyncia
Synonyms
delicate cyncia
Rank
species
Lineage
Show more ... ecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Noctuoidea; Erebidae; Arctiinae; Phaegopterini; Cycnia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
Taxon B #2
Common Name
-
Synonyms
Lerina incarnata Walker, 1854
Rank
species
Lineage
Show more ... ecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Noctuoidea; Erebidae; Arctiinae; Phaegopterini; Lerina
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Atp1a1
Synonyms
Atpa-1; BC010319
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Q111L
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Gln Leu 111
Authors
Zhen Y; Aardema ML; Medina EM; Schumer M; Andolfatto P
Abstract
Numerous insects have independently evolved the ability to feed on plants that produce toxic secondary compounds called cardenolides and can sequester these compounds for use in their defense. We surveyed the protein target for cardenolides, the alpha subunit of the sodium pump, Na(+),K(+)-ATPase (ATPα), in 14 species that feed on cardenolide-producing plants and 15 outgroups spanning three insect orders. Despite the large number of potential targets for modulating cardenolide sensitivity, amino acid substitutions associated with host-plant specialization are highly clustered, with many parallel substitutions. Additionally, we document four independent duplications of ATPα with convergent tissue-specific expression patterns. We find that unique substitutions are disproportionately associated with recent duplications relative to parallel substitutions. Together, these findings support the hypothesis that adaptation tends to take evolutionary paths that minimize negative pleiotropy.
COMMENTS
The Q111L mutation may have occurred in a past ancestor (see Figure S6 of Ujvari et al. 2015)
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