GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000732
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Thamnophis sirtalis - sensitive
Trait State in Taxon B
Thamnophis sirtalis - resistant - Willow creek
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
-
Synonyms
FMNH 73660; FMNH:73660
Rank
species
Lineage
Show more ... erygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
FMNH 73660; FMNH:73660
Rank
species
Lineage
Show more ... erygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
I1556L and/or D1568N and/or G1569V
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Geffeney SL; Fujimoto E; Brodie ED; Brodie ED; Ruben PC
Abstract
Understanding the molecular genetic basis of adaptations provides incomparable insight into the genetic mechanisms by which evolutionary diversification takes place. Whether the evolution of common traits in different lineages proceeds by similar or unique mutations, and the degree to which phenotypic evolution is controlled by changes in gene regulation as opposed to gene function, are fundamental questions in evolutionary biology that require such an understanding of genetic mechanisms. Here we identify novel changes in the molecular structure of a sodium channel expressed in snake skeletal muscle, tsNa(V)1.4, that are responsible for differences in tetrodotoxin (TTX) resistance among garter snake populations coevolving with toxic newts. By the functional expression of tsNa(V)1.4, we show how differences in the amino-acid sequence of the channel affect TTX binding and impart different levels of resistance in four snake populations. These results indicate that the evolution of a physiological trait has occurred through a series of unique functional changes in a gene that is otherwise highly conserved among vertebrates.
RELATED GEPHE
Related Haplotypes
2
COMMENTS
Extreme TTX resistance evolved 5 times in Nav1.4 channel; but only in lineages that had previously evolved resistance in paralogous NaV channels
YOUR FEEDBACK is welcome!