GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000738
Main curator
Courtier
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait
Trait State in Taxon A
can survive without 7-dehydroxylated sterols
Trait State in Taxon B
cannot survive without 7-dehydroxylated sterols
Trait #2
Trait Category
Trait State in Taxon A
can survive on standard Drosophila fly food
Trait State in Taxon B
cannot survive without senita cactus or 7-dehydroxylated sterols
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ...
; Holometabola; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Drosophila; nannoptera group
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ...
; Holometabola; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Drosophila; nannoptera group
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
nvd
Synonyms
CG40050; Dmel\CG40050; Nvd; nvd-Dm; Dmel_CG40050
String
Sequence Similarities
-
GO - Molecular Function
GO:0016491 : oxidoreductase activity
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GO - Biological Process
GO:0035264 : multicellular organism growth
... show more
GO - Cellular Component
Mutation #1
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Four a.a. substitutions G250A L330I G376T E377G - each one decreases enzyme activity
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | Gly | Ala | 250 |
Main Reference
Authors
Lang M; Murat S; Clark AG; Gouppil G; Blais C; Matzkin LM; Guittard E; Yoshiyama-Yanagawa T; et al.
... show more
Abstract
Most living species exploit a limited range of resources. However, little is known about how tight associations build up during evolution between such specialist species and the hosts they use. We examined the dependence of Drosophila pachea on its single host, the senita cactus. Several amino acid changes in the Neverland oxygenase rendered D. pachea unable to transform cholesterol into 7-dehydrocholesterol (the first reaction in the steroid hormone biosynthetic pathway in insects) and thus made D. pachea dependent on the uncommon sterols of its host plant. The neverland mutations increase survival on the cactus's unusual sterols and are in a genomic region that faced recent positive selection. This study illustrates how relatively few genetic changes in a single gene may restrict the ecological niche of a species.
Additional References
Mutation #2
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Four a.a. substitutions G250A L330I G376T E377G - each one decreases enzyme activity
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | Leu | Ile | 330 |
Main Reference
Authors
Lang M; Murat S; Clark AG; Gouppil G; Blais C; Matzkin LM; Guittard E; Yoshiyama-Yanagawa T; et al.
... show more
Abstract
Most living species exploit a limited range of resources. However, little is known about how tight associations build up during evolution between such specialist species and the hosts they use. We examined the dependence of Drosophila pachea on its single host, the senita cactus. Several amino acid changes in the Neverland oxygenase rendered D. pachea unable to transform cholesterol into 7-dehydrocholesterol (the first reaction in the steroid hormone biosynthetic pathway in insects) and thus made D. pachea dependent on the uncommon sterols of its host plant. The neverland mutations increase survival on the cactus's unusual sterols and are in a genomic region that faced recent positive selection. This study illustrates how relatively few genetic changes in a single gene may restrict the ecological niche of a species.
Additional References
Mutation #3
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Four a.a. substitutions G250A L330I A376T E377G - each one decreases enzyme activity
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | GCG | ACG | - |
Amino-acid | Ala | Thr | 376 |
Main Reference
Authors
Lang M; Murat S; Clark AG; Gouppil G; Blais C; Matzkin LM; Guittard E; Yoshiyama-Yanagawa T; et al.
... show more
Abstract
Most living species exploit a limited range of resources. However, little is known about how tight associations build up during evolution between such specialist species and the hosts they use. We examined the dependence of Drosophila pachea on its single host, the senita cactus. Several amino acid changes in the Neverland oxygenase rendered D. pachea unable to transform cholesterol into 7-dehydrocholesterol (the first reaction in the steroid hormone biosynthetic pathway in insects) and thus made D. pachea dependent on the uncommon sterols of its host plant. The neverland mutations increase survival on the cactus's unusual sterols and are in a genomic region that faced recent positive selection. This study illustrates how relatively few genetic changes in a single gene may restrict the ecological niche of a species.
Additional References
Mutation #4
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Four a.a. substitutions G250A L330I G376T E377G - each one decreases enzyme activity
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | GAA | GGA | - |
Amino-acid | Glu | Gly | 377 |
Main Reference
Authors
Lang M; Murat S; Clark AG; Gouppil G; Blais C; Matzkin LM; Guittard E; Yoshiyama-Yanagawa T; et al.
... show more
Abstract
Most living species exploit a limited range of resources. However, little is known about how tight associations build up during evolution between such specialist species and the hosts they use. We examined the dependence of Drosophila pachea on its single host, the senita cactus. Several amino acid changes in the Neverland oxygenase rendered D. pachea unable to transform cholesterol into 7-dehydrocholesterol (the first reaction in the steroid hormone biosynthetic pathway in insects) and thus made D. pachea dependent on the uncommon sterols of its host plant. The neverland mutations increase survival on the cactus's unusual sterols and are in a genomic region that faced recent positive selection. This study illustrates how relatively few genetic changes in a single gene may restrict the ecological niche of a species.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@SeveralMutationsWithEffect
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