GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000739
Main curator
Courtier
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait
Trait State in Taxon A
C. elegans - RC301 - social
Trait State in Taxon B
C. elegans - N2 - solitary
Trait #2
Trait Category
Trait
Trait State in Taxon A
-
Trait State in Taxon B
-
Trait #3
Trait Category
Trait
Trait State in Taxon A
-
Trait State in Taxon B
-
Trait #4
Trait Category
Trait
Trait State in Taxon A
-
Trait State in Taxon B
-
Trait #5
Trait Category
Trait State in Taxon A
-
Trait State in Taxon B
higher
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
roundworm; Rhabditis elegans; Caenorhabditis elegans (Maupas, 1900); Rhabditis elegans Maupas, 1900
Rank
species
Lineage
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s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
C. elegans - RC301 and CB4856 (wild isolate)
Taxon B
Latin Name
Common Name
-
Synonyms
roundworm; Rhabditis elegans; Caenorhabditis elegans (Maupas, 1900); Rhabditis elegans Maupas, 1900
Rank
species
Lineage
Show more ...
s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
C. elegans - N2 - solitary
GENOTYPIC CHANGE
Generic Gene Name
npr-1
Synonyms
C39E6.6; CELE_C39E6.6
String
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
GO - Molecular Function
GO:0008188 : neuropeptide receptor activity
... show more
GO - Biological Process
GO:0043052 : thermotaxis
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GO - Cellular Component
GO:0005886 : plasma membrane
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Val215Phe (pleiotropic; see other entries)
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
de Bono M; Bargmann CI
Abstract
Natural isolates of C. elegans exhibit either solitary or social feeding behavior. Solitary foragers move slowly on a bacterial lawn and disperse across it, while social foragers move rapidly on bacteria and aggregate together. A loss-of-function mutation in the npr-1 gene, which encodes a predicted G protein-coupled receptor similar to neuropeptide Y receptors, causes a solitary strain to take on social behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild. One isoform, NPR-1 215F, is found exclusively in social strains, while the other isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene can induce solitary feeding behavior in a wild social strain. Thus, isoforms of a putative neuropeptide receptor generate natural variation in C. elegans feeding behavior.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
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