GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000745
Main curator
Courtier
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait
Trait State in Taxon A
Astyanax mexicanus surface
Trait State in Taxon B
Astyanax mexicanus Molino
Trait #2
Trait Category
Trait
Trait State in Taxon A
Astyanax mexicanus surface
Trait State in Taxon B
Astyanax mexicanus Molino
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
Mexican tetra
Synonyms
Mexican tetra; blind cave fish; Astyanax mexicanus (De Filippi, 1853)
Rank
species
Lineage
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eopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Characiphysae; Characiformes; Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; Astyanax
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Mexican tetra
Synonyms
Mexican tetra; blind cave fish; Astyanax mexicanus (De Filippi, 1853)
Rank
species
Lineage
Show more ...
eopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Characiphysae; Characiformes; Characoidei; Characidae; Characidae incertae sedis; Astyanax clade; Astyanax
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Astyanax mexicanus Molino
GENOTYPIC CHANGE
Generic Gene Name
Oca2
Synonyms
p; D7Nic1; p<cas>; D7H15S12; D7Icr28RN; P
String
Sequence Similarities
Belongs to the CitM (TC 2.A.11) transporter family.
GO - Molecular Function
-
GO - Biological Process
GO:0055085 : transmembrane transport
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GO - Cellular Component
GO:0016021 : integral component of membrane
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Presumptive Null
Molecular Type
Aberration Type
Deletion Size
-
Molecular Details of the Mutation
Deletion of exon 21
Experimental Evidence
Main Reference
Authors
Protas ME; Hersey C; Kochanek D; Zhou Y; Wilkens H; Jeffery WR; Zon LI; Borowsky R; et al.
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Abstract
The genetic basis of vertebrate morphological evolution has traditionally been very difficult to examine in naturally occurring populations. Here we describe the generation of a genome-wide linkage map to allow quantitative trait analysis of evolutionarily derived morphologies in the Mexican cave tetra, a species that has, in a series of independent caves, repeatedly evolved specialized characteristics adapted to a unique and well-studied ecological environment. We focused on the trait of albinism and discovered that it is linked to Oca2, a known pigmentation gene, in two cave populations. We found different deletions in Oca2 in each population and, using a cell-based assay, showed that both cause loss of function of the corresponding protein, OCA2. Thus, the two cave populations evolved albinism independently, through similar mutational events.
EXTERNAL LINKS
COMMENTS
@Parallelism @Pleiotropy https://omia.org/OMIA002130/7994/
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