GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000780
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
littoral cottoid fishes; Lake Baikal
Trait State in Taxon B
abyssal cottoid fishes; Lake Baikal
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Baikalian cottoid fish
Rank
species
Lineage
Show more ... cephalai; Clupeocephala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; unclassified Cottoidei
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
Baikalian cottoid fish
Rank
species
Lineage
Show more ... cephalai; Clupeocephala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; unclassified Cottoidei
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
RHO
Synonyms
RP4; OPN2; CSNBAD1
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Mutation #1
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
D83N; A292S
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Asp Asn 83
Authors
Hunt DM; Fitzgibbon J; Slobodyanyuk SJ; Bowmaker JK
Abstract
Lake Baikal in Eastern Siberia is the deepest and one of the largest and most ancient lakes in the world. However, even in the deepest regions, oxygenation levels do not fall below 75-80% of the surface levels. This has enabled a remarkable flock of largely endemic teleost fish of the sub-order Cottoidei to colonize all depth habitats. We have previously shown that species that occupy progressively deeper habitats show a blue shift in the peak wavelength of absorbance (lambda max) of both their rod and cone visual pigments; for the rod pigments, a number of stepwise shifts occur from about 516 nm in littoral species to about 484 nm in abyssal species. By sequencing the rod opsin gene from 11 species of Baikal cottoids that include representatives from all depth habitats, we have been able to identify four amino acid substitutions that would account for these shifts. The effect of each substitution on lambda max is approximately additive and each corresponds to a particular lineage of evolution.
Additional References
Mutation #2
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
D83N; A292S
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Ala Ser 292
Authors
Hunt DM; Fitzgibbon J; Slobodyanyuk SJ; Bowmaker JK
Abstract
Lake Baikal in Eastern Siberia is the deepest and one of the largest and most ancient lakes in the world. However, even in the deepest regions, oxygenation levels do not fall below 75-80% of the surface levels. This has enabled a remarkable flock of largely endemic teleost fish of the sub-order Cottoidei to colonize all depth habitats. We have previously shown that species that occupy progressively deeper habitats show a blue shift in the peak wavelength of absorbance (lambda max) of both their rod and cone visual pigments; for the rod pigments, a number of stepwise shifts occur from about 516 nm in littoral species to about 484 nm in abyssal species. By sequencing the rod opsin gene from 11 species of Baikal cottoids that include representatives from all depth habitats, we have been able to identify four amino acid substitutions that would account for these shifts. The effect of each substitution on lambda max is approximately additive and each corresponds to a particular lineage of evolution.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
@SeveralMutationsWithEffect
YOUR FEEDBACK is welcome!