GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000781
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Other bats
Trait State in Taxon B
Megaderma lyra
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
bats
Synonyms
bats
Rank
order
Lineage
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uterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Indian false vampire
Synonyms
Indian false vampire; greater false vampire bat
Rank
species
Lineage
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ta; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Chiroptera; Microchiroptera; Megadermatidae; Megaderma
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
RHO
Synonyms
RP4; OPN2; CSNBAD1
String
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
GO - Molecular Function
GO:0046872 : metal ion binding
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GO - Biological Process
GO - Cellular Component
GO:0016021 : integral component of membrane
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UniProtKB
Homo sapiens
Homo sapiens
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
D83N
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Sugawara T; Imai H; Nikaido M; Imamoto Y; Okada N
Abstract
Rhodopsin is a photoreceptive protein present in vertebrate rod photoreceptor cells, which are responsible for scotopic vision. Recent molecular studies have shown that several aquatic vertebrate species have independently acquired rhodopsin containing Asp83Asn, Glu122Gln, and Ala292Ser substitutions, causing a blue shift in the rhodopsin absorption spectra for adaptation to the blue-green photic environment in deep water. Here, we provide new evidence for the evolutionary and functional relevance of the Asp83Asn substitution. Spectroscopic and kinetic analyses of rhodopsins in six cichlid fishes from the East African Great Lakes using charge-coupled device spectrophotometer revealed that the Asp83Asn substitution accelerated the formation of meta-II, a rhodopsin intermediate crucial for activation of the G-protein transducin. Because rapid formation of meta-II likely results in effective transduction of photic signals, it is reasonable to assume that deep-water cichlid species have acquired rhodopsin containing Asn83 to adapt to dim lighting. Remarkably, rhodopsin containing Asn83 has been identified in terrestrial vertebrates such as bats, and these rhodopsin variants also exhibit accelerated meta-II formation. Our results indicated that the Asp83Asn substitution observed in a variety of animal species was acquired independently in many different lineages during vertebrate evolution for adaptation to dimly lit environments.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
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