GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000784
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Amniote ancestor
Trait State in Taxon B
lizards; chameleon
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
amniotes
Synonyms
amniotes
Rank
no rank
Lineage
Show more ... rganisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
squamates
Synonyms
squamates
Rank
order
Lineage
Show more ... Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
RHO
Synonyms
RP4; OPN2; CSNBAD1
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
D83N
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Yokoyama S; Zhang H; Radlwimmer FB; Blow NS
Abstract
The coelacanth, a "living fossil," lives near the coast of the Comoros archipelago in the Indian Ocean. Living at a depth of about 200 m, the Comoran coelacanth receives only a narrow range of light, at about 480 nm. To detect the entire range of "color" at this depth, the coelacanth appears to use only two closely related paralogous RH1 and RH2 visual pigments with the optimum light sensitivities (lambdamax) at 478 nm and 485 nm, respectively. The lambdamax values are shifted about 20 nm toward blue compared with those of the corresponding orthologous pigments. Mutagenesis experiments show that each of these coadapted changes is fully explained by two amino acid replacements.
EXTERNAL LINKS
COMMENTS
Phylogenetic position of the change remains ambivalent
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