GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000790
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Other fishes and tetrapods
Trait State in Taxon B
Latimeria
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
teleost fishes
Synonyms
teleost fishes
Rank
infraclass
Lineage
Show more ... ular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B #1
Common Name
Menado coelacanth
Synonyms
Menado coelacanth; king of the sea; Latimeria menadoensis Pouyaud, Wirjoatmodjo, Rachmatika, Tjakrawidjaja, Hadiaty & Hadie, 1999
Rank
species
Lineage
Show more ... a; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Coelacanthimorpha; Coelacanthiformes; Coelacanthidae; Latimeria
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
Taxon B #2
Common Name
coelacanth
Synonyms
coelacanth; Latimeria chalumnae Smith, 1939
Rank
species
Lineage
Show more ... a; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Coelacanthimorpha; Coelacanthiformes; Coelacanthidae; Latimeria
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
RHO
Synonyms
RP4; OPN2; CSNBAD1
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Mutation #1
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
A292S; E122Q - both have an effect
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Glu Gln 122
Authors
Yokoyama S; Tada T
Abstract
We have PCR amplified and sequenced the rhodopsin (RH1) and evolutionarily closely related RH2 genes of the Indonesian coelacanth, now referred to as Latimeria menadoensis. When the RH1 and RH2 coding sequences are constructed, expressed in cultured cells, and reconstituted with 11-cis-retinal, the resulting visual pigments have wavelengths of maximal absorption (lambda(max)) of 485 and 479 nm, respectively. These lambda(max) values are identical to those of the African coelacanth, Latimeria chalumnae, showing that the Indonesian coelacanths also detect a narrow range of color. Statistical analyses show that the adaptation of the coelacanths toward the deep-sea started as early as 200 million years ago.
Additional References
Mutation #2
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
A292S; E122Q - both have an effect
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Ala Ser 292
Authors
Yokoyama S; Tada T
Abstract
We have PCR amplified and sequenced the rhodopsin (RH1) and evolutionarily closely related RH2 genes of the Indonesian coelacanth, now referred to as Latimeria menadoensis. When the RH1 and RH2 coding sequences are constructed, expressed in cultured cells, and reconstituted with 11-cis-retinal, the resulting visual pigments have wavelengths of maximal absorption (lambda(max)) of 485 and 479 nm, respectively. These lambda(max) values are identical to those of the African coelacanth, Latimeria chalumnae, showing that the Indonesian coelacanths also detect a narrow range of color. Statistical analyses show that the adaptation of the coelacanths toward the deep-sea started as early as 200 million years ago.
Additional References
COMMENTS
@SeveralMutationsWithEffect - The two amino acid changes are found in both coelacanth species
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