GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000826
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Blatella germanica
Trait State in Taxon B
Blatella germanica - resistant - allele 2
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
German cockroach
Synonyms
German cockroach; Blattella germanica (Linnaeus, 1767); Blatella germanica
Rank
species
Lineage
Show more ... ysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae; Blattellinae; Blattella
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
German cockroach
Synonyms
German cockroach; Blattella germanica (Linnaeus, 1767); Blatella germanica
Rank
species
Lineage
Show more ... ysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae; Blattellinae; Blattella
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
E434K (=E435K)
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Liu Z; Valles SM; Dong K
Abstract
Knockdown resistance (kdr) to pyrethroid insecticides has been attributed to point mutations in the para sodium channel gene in more than a half dozen insect pest species. In this study, we identified two novel para mutations in five highly resistant kdr-type German cockroach strains. The two mutations, from glutamic acid (E434) to lysine (K434) and from cysteine (C764) to arginine (R764), respectively, are located in the first intracellular linker connecting domains I and II. E434K is located near the beginning of the linker (closest to domain I), whereas C764R is found toward the end of the linker (closest to domain II). Two additional mutations from aspartic acid (D58) to glycine (G58), and from proline (P1880) to leucine (L1888), respectively, were found in one of the resistant strains. The four mutations coexist with the previously identified leucine to phenylalanine (L993F) kdr mutation in IIS6, and are present only in the highly resistant individuals of a given strain. These findings suggest that these mutations might be responsible for high levels of knockdown resistance toward pyrethroid insecticides in the German cockroach.
RELATED GEPHE
Related Haplotypes
2
EXTERNAL LINKS
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