GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000827
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Boophilus microplus
Trait State in Taxon B
Boophilus microplus - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
southern cattle tick
Synonyms
Boophilus microplus; Rhipicephalus (Boophilus) microplus; southern cattle tick; cattle tick; Rhipicephalus microplus (Canestrini, 1888)
Rank
species
Lineage
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Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae; Rhipicephalus; Boophilus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
southern cattle tick
Synonyms
Boophilus microplus; Rhipicephalus (Boophilus) microplus; southern cattle tick; cattle tick; Rhipicephalus microplus (Canestrini, 1888)
Rank
species
Lineage
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Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae; Rhipicephalus; Boophilus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
para
Synonyms
bas; bss; CG9907; Dmel\CG9907; DmNav; DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da; l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; sbl; sbl-1; Shu; Shudderer
String
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
GO - Molecular Function
GO:0005509 : calcium ion binding
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GO - Biological Process
GO - Cellular Component
GO:0005887 : integral component of plasma membrane
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
F1538I
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | - | - | - |
| Amino-acid | - | - | - |
Main Reference
Authors
He H; Chen AC; Davey RB; Ivie GW; George JE
Abstract
To investigate the molecular mechanism of resistance to pyrethroids in the southern cattle tick, Boophilus microplus, we have obtained and sequenced a partial para-homologous sodium channel cDNA from susceptible and pyrethroid-resistant tick strains. A point mutation that results in an amino acid change from Phe to Ile was identified in the highly conserved domain IIIS6 of the homologous sodium channel from ticks that are highly resistant to pyrethroid acaricides. This mutation is at a location different from those reported in the same gene in pyrethroid-resistant insects.
Copyright 1999 Academic Press.
Copyright 1999 Academic Press.
RELATED GEPHE
Related Haplotypes
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