GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00000886
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Gasterosteus aculeatus - marine
Trait State in Taxon B
Gasterosteus aculeatus - freshwater
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Gasterosteus aculeatus - marine
Taxon B
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Gasterosteus aculeatus - freshwater
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
Deletion Size
1-10 kb
Molecular Details of the Mutation
488bp promoter region : deletion 1 ; 5 kb deletion
Experimental Evidence
Authors
Shapiro MD; Marks ME; Peichel CL; Blackman BK; Nereng KS; Jónsson B; Schluter D; Kingsley DM
Abstract
Hindlimb loss has evolved repeatedly in many different animals by means of molecular mechanisms that are still unknown. To determine the number and type of genetic changes underlying pelvic reduction in natural populations, we carried out genetic crosses between threespine stickleback fish with complete or missing pelvic structures. Genome-wide linkage mapping shows that pelvic reduction is controlled by one major and four minor chromosome regions. Pitx1 maps to the major chromosome region controlling most of the variation in pelvic size. Pelvic-reduced fish show the same left-right asymmetry seen in Pitx1 knockout mice, but do not show changes in Pitx1 protein sequence. Instead, pelvic-reduced sticklebacks show site-specific regulatory changes in Pitx1 expression, with reduced or absent expression in pelvic and caudal fin precursors. Regulatory mutations in major developmental control genes may provide a mechanism for generating rapid skeletal changes in natural populations, while preserving the essential roles of these genes in other processes.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
8
COMMENTS
@Parallelism @Multi-allelic
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