GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000934
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Mus musculus
Trait State in Taxon B
Carollia perspicillata
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
house mouse
Synonyms
house mouse; mouse; Mus musculus Linnaeus, 1758; mice C57BL/6xCBA/CaJ hybrid
Rank
species
Lineage
Show more ... i; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
Seba's short-tailed bat
Synonyms
Seba's short-tailed bat; Carollia perspicillata (Linnaeus, 1758)
Rank
species
Lineage
Show more ... mi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae; Carolliinae; Carollia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Prrx1
Synonyms
K-2; Pmx; Pmx1; Prx1; mHox; AA755424; AI385634; AI843499; A230024N07Rik
Sequence Similarities
Belongs to the paired homeobox family.
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Not identified
Experimental Evidence
Authors
Cretekos CJ; Wang Y; Green ED; Martin JF; Rasweiler JJ; Behringer RR
Abstract
Natural selection acts on variation within populations, resulting in modified organ morphology, physiology, and ultimately the formation of new species. Although variation in orthologous proteins can contribute to these modifications, differences in DNA sequences regulating gene expression may be a primary source of variation. We replaced a limb-specific transcriptional enhancer of the mouse Prx1 locus with the orthologous sequence from a bat. Prx1 expression directed by the bat enhancer results in elevated transcript levels in developing forelimb bones and forelimbs that are significantly longer than controls because of endochondral bone formation alterations. Surprisingly, deletion of the mouse Prx1 limb enhancer results in normal forelimb length and Prx1 expression, revealing regulatory redundancy. These findings suggest that mutations accumulating in pre-existing noncoding regulatory sequences within a population are a source of variation for the evolution of morphological differences between species and that cis-regulatory redundancy may facilitate accumulation of such mutations.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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