GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000968
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Aedes aegypti
Trait State in Taxon B
Aedes aegypti - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
yellow fever mosquito
Synonyms
Stegomyia aegypti; yellow fever mosquito; Aedes aegypti (Linnaeus, 1762)
Rank
species
Lineage
Show more ... ; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Aedini; Aedes; Stegomyia
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
yellow fever mosquito
Synonyms
Stegomyia aegypti; yellow fever mosquito; Aedes aegypti (Linnaeus, 1762)
Rank
species
Lineage
Show more ... ; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Aedini; Aedes; Stegomyia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Rdl
Synonyms
CG10537; CT29555; Dmel\CG10537; DmRdl; DmRDL; gaba; GABA; GABA-R; GABAr; GABA[[A]]; GABA[[A]] receptor; GABA[[A]]-R; GABA[[A]]R; LCCH1; Rd1; rdl; RDL
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Ala302Ser
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Thompson M; Shotkoski F; ffrench-Constant R
Abstract
In order to examine the conservation of the mechanism of cyclodiene insecticide resistance between species we cloned a cDNA from the yellow fever mosquito Aedes aegypti homologous to the resistance gene Rdl in Drosophila. In D. melanogaster, resistance to cyclodienes and picrotoxinin is caused by a single amino acid substitution (alanine to serine) in the putative channel lining of a gamma-aminobutyic acid gated chloride ion channel. We report that the mosquito gene not only shows high homology to that of Drosophila but also that resistant strains display substitution of the same amino acid. The significance of this result in relation to the evolution of pesticide resistance, the use of Drosophila as a model insect for resistance studies and the potential use of this gene as a selectable marker in the genetic transformation of non-Drosophilids is discussed.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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