GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000970
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Anopheles gambiae
Trait State in Taxon B
Anopheles gambiae - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
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tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
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tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Rdl
Synonyms
CG10537; CT29555; Dmel\CG10537; DmRdl; DmRDL; gaba; GABA; GABA-R; GABAr; GABA[[A]]; GABA[[A]] receptor; GABA[[A]]-R; GABA[[A]]R; LCCH1; Rd1; rdl; RDL
String
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
GO - Molecular Function
GO:0004890 : GABA-A receptor activity
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GO - Biological Process
GO:0007165 : signal transduction
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GO - Cellular Component
GO:0016021 : integral component of membrane
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Ala302Gly
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | - | - | - |
| Amino-acid | - | - | - |
Main Reference
Authors
Du W; Awolola TS; Howell P; Koekemoer LL; Brooke BD; Benedict MQ; Coetzee M; Zheng L
Abstract
Substitutions of a conserved alanine residue in the Rdl locus coding for a gamma-aminobutyric acid (GABA) receptor subunit with serine or glycine confer resistance to dieldrin in various insect species. Here, we show that alanine to glycine substitution in the Rdl locus of the malaria vector, Anopheles gambiae, is genetically linked to resistance to dieldrin. An alanine to serine substitution developed independently in a dieldrin resistant strain of An. arabiensis. An allele-specific polymerase chain reaction (PCR) assay was able to differentiate dieldrin resistant and susceptible mosquitoes.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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