GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000972
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Blatella germanica
Trait State in Taxon B
Blatella germanica - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
German cockroach
Synonyms
German cockroach; Blattella germanica (Linnaeus, 1767); Blatella germanica
Rank
species
Lineage
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ysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae; Blattellinae; Blattella
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
German cockroach
Synonyms
German cockroach; Blattella germanica (Linnaeus, 1767); Blatella germanica
Rank
species
Lineage
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ysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae; Blattellinae; Blattella
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Rdl
Synonyms
CG10537; CT29555; Dmel\CG10537; DmRdl; DmRDL; gaba; GABA; GABA-R; GABAr; GABA[[A]]; GABA[[A]] receptor; GABA[[A]]-R; GABA[[A]]R; LCCH1; Rd1; rdl; RDL
String
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
GO - Molecular Function
GO:0004890 : GABA-A receptor activity
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GO - Biological Process
GO:0007165 : signal transduction
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GO - Cellular Component
GO:0016021 : integral component of membrane
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Ala302Ser
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Kaku K; Matsumura F
Abstract
The DNA and amino acid sequences of the membrane-spanning region of the GABA receptors of the German cockroach have been identified along with information on the nature and the specific site of mutation in the cyclodiene-resistant strains. In this resistant strain, the mutation has occurred at the most conserved, lower M2 cylinder region involving a G to T conversion, resulting in an amino acid change of alanine (GCC) residue to serine (TCC). The site, furthermore, coincides with the most conserved region of all GABA receptor subunits and the expected Cl- transporting segment constituting the innermost surface of the channel opening. The deduced sequence of the German cockroach GABA receptor differs from that of Drosophila mainly in the connecting region between M3 and M4.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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