GEPHE SUMMARY
Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000098
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Anopheles gambiae - sensitive
Trait State in Taxon B
Anopheles gambiae - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
Show more ...
tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
Show more ...
tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
APL1A
Synonyms
AGAP007036
String
-
Sequence Similarities
-
GO - Molecular Function
-
GO - Biological Process
-
GO - Cellular Component
-
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Not identified
Experimental Evidence
Main Reference
Authors
Riehle MM; Markianos K; Niaré O; Xu J; Li J; Touré AM; Podiougou B; Oduol F; et al.
... show more
Abstract
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.
RELATED GEPHE
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Cluster of paralogous genes
YOUR FEEDBACK is welcome!