Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 13 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
eosinophil-derived neurotoxin (EDN)	Increase in antiviral ribonuclease activity	Coding, SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Zhang J; Rosenberg HF (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.	GP00000272	RNASE2 P10153	Physiology	Arg64Ser	Primates (order)	Catarrhini (parvorder)	eosinophil-derived neurotoxin (EDN)	Catarrhini (parvorder)	Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)	Increase in antiviral ribonuclease activity	Coding, SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Zhang J; Rosenberg HF (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.	GP00000273	RNASE2 P10153	Physiology	Thr132Arg	Primates (order)	Catarrhini (parvorder)	eosinophil-derived neurotoxin (EDN)	Catarrhini (parvorder)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Primates (order)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000422	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Primates (order)	Gulo	Primates (order)	Published - Accepted by Curator
interleukin-4	Immune response	Cis-regulatory, SNP	Homo sapiens human - (species)	Interspecific	Candidate Gene	Rockman MV; Hahn MW; Soranzo N ; et al. (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression.	GP00000504	IL4R P24394	Physiology	1bp substitution in promoter	Primates (order)	Homo sapiens human - (species)	interleukin-4	Homo sapiens human - (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Colobinae (subfamily)	Intergeneric or Higher	Candidate Gene	Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2) Adaptive evolution in the stomach lysozymes of foregut fermenters. 3 Additional References Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin. Swanson KW; Irwin DM; Wilson AC (1991) Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection. Messier W; Stewart CB (1997) Episodic adaptive evolution of primate lysozymes.	GP00000558	LYZ1 P04421	Physiology	5 mutations	Primates (order)	Colobinae (subfamily)	lysozyme	Colobinae (subfamily)	Published - Accepted by Curator
opsin - rhodopsin (MWS=duplicate of LWS)	Color vision (green-shift)	7 Mutations: Coding SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Asenjo AB; Rim J; Oprian DD (1994) Molecular determinants of human red/green color discrimination. 1 Additional References Hunt DM; Dulai KS; Cowing JA (1998) Molecular evolution of trichromacy in primates.	GP00000778	OPN1MW P04001	Physiology	7 mutations	Primates (order)	Catarrhini (parvorder)	opsin - rhodopsin (MWS=duplicate of LWS)	Catarrhini (parvorder)	Published - Accepted by Curator
prodynorphin (PDYN)	Neuroendocronological homeostasis	Cis-regulatory, SNP	Homo sapiens human - (species)	Interspecific	Candidate Gene	Rockman MV; Hahn MW; Soranzo N ; et al. (2005) Ancient and recent positive selection transformed opioid cis-regulation in humans. 1 Additional References Babbitt CC; Silverman JS; Haygood R (2010) Multiple Functional Variants in cis Modulate PDYN Expression.	GP00000924	PDYN P01213	Physiology	up to 5 polymorphisms in 5' regulatory region	Primates (order)	Homo sapiens human - (species)	prodynorphin (PDYN)	Homo sapiens human - (species)	Published - Accepted by Curator
Prolactin (deciduous Prolactin; dPRL)	Gene expression change (quantitative; increase)	Cis-regulatory, SNP	Homininae (subfamily)	Intergeneric or Higher	Candidate Gene	Emera D; Wagner GP (2012) Transformation of a transposon into a derived prolactin promoter with function during human pregnanc[...]	GP00000926	PRL P01236	Physiology	Acquisition of enhancer activity in transposons via several base-pair substitutions	Primates (order)	Homininae (subfamily)	Prolactin (deciduous Prolactin; dPRL)	Homininae (subfamily)	Published - Accepted by Curator
ribonuclease 1B (RNase1B)	Optimal enzymatic pH	3 Mutations: Coding SNP	Pygathrix nemaeus Red shanked douc langur - (species) D	Intergeneric or Higher	Candidate Gene	Zhang J (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.	GP00000987	RNASE1B Q8SPN3	Physiology	3 mutations	Primates (order)	Pygathrix nemaeus Red shanked douc langur - (species) D	ribonuclease 1B (RNase1B)	Pygathrix nemaeus Red shanked douc langur - (species)	Published - Accepted by Curator
ribonuclease 1B (RNase1B)	Optimal enzymatic pH	3 Mutations: Coding SNP	Colobus guereza mantled guereza - (species)	Intergeneric or Higher	Candidate Gene	Zhang J (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.	GP00000988	RNASE1B Q8SPN3	Physiology	3 mutations	Primates (order)	Colobus guereza mantled guereza - (species)	ribonuclease 1B (RNase1B)	Colobus guereza mantled guereza - (species)	Published - Accepted by Curator
SIGLEC13	Pathogen resistance	Gene Loss, Complex Change N	Homo sapiens human - (species)	Interspecific	Candidate Gene	Wang X; Mitra N; Secundino I ; et al. (2012) Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.	GP00001052	SIGLEC13 Q64JA4	Physiology	Gene deletion by Alu-mediated recombination N	Primates (order)	Homo sapiens human - (species)	SIGLEC13	Homo sapiens human - (species)	Published - Accepted by Curator
SIGLEC17P (pseudogene)	Pathogen resistance	Coding, Deletion N	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Wang X; Mitra N; Secundino I ; et al. (2012) Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.	GP00001053	SIGLEC13 Q64JA4	Physiology	1bp deletion resulting in frame-shift (pseudogenization) N	Primates (order)	Homo sapiens human - (species) D	SIGLEC17P (pseudogene)	Homo sapiens human - (species)	Published - Accepted by Curator
SRGAP2	Neuronal maturation	Gene Amplification, Complex Change	Primates (order)	Intergeneric or Higher	Candidate Gene	Charrier C; Joshi K; Coutinho-Budd J ; et al. (2012) Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation[...] 1 Additional References Dennis MY; Nuttle X; Sudmant PH (2012) Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	GP00001077	Srgap2 Q91Z67	Physiology	Partial duplications (negative alleles)	Homo sapiens human - (species)	Primates (order)	SRGAP2	Primates (order)	Published - Accepted by Curator