GEPHE SUMMARY
Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001862
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Trialeurodes vaporariorum
Trait State in Taxon B
Trialeurodes vaporariorum - resistant
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
greenhouse whitefly
Synonyms
greenhouse whitefly; Trialeurodes vaporariorum (Westwood, 1856); Trialeurodes vaporarium
Rank
species
Lineage
Show more ...
Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aleyrodoidea; Aleyrodidae; Aleyrodinae; Trialeurodes
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
greenhouse whitefly
Synonyms
greenhouse whitefly; Trialeurodes vaporariorum (Westwood, 1856); Trialeurodes vaporarium
Rank
species
Lineage
Show more ...
Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aleyrodoidea; Aleyrodidae; Aleyrodinae; Trialeurodes
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
para
Synonyms
bas; bss; CG9907; Dmel\CG9907; DmNav; DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da; l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; sbl; sbl-1; Shu; Shudderer
String
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
GO - Molecular Function
GO:0005509 : calcium ion binding
... show more
GO - Biological Process
GO - Cellular Component
GO:0005887 : integral component of plasma membrane
... show more
UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Mutation #1
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
L925I
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | TTA | ATA | - |
| Amino-acid | Leu | Ile | 925 |
Main Reference
Authors
Karatolos N; Gorman K; Williamson MS; Denholm I
Abstract
Trialeurodes vaporariorum Westwood is an important pest of protected crops in temperate regions of the world. Resistance to pyrethroid insecticides is long established in this species, but the molecular basis of the mechanism(s) responsible has not previously been disclosed.
Mortality rates of three European strains of T. vaporariorum to the pyrethroid bifenthrin were calculated, and each possessed significant resistance (up to 662-fold) when compared with a susceptible reference strain. Direct sequencing revealed three amino acid substitutions in the para-type voltage-gated sodium channel (the pyrethroid and DDT target site) of bifenthrin-resistant T. vaporariorum at positions previously implicated with pyrethroid or DDT resistance (M918L, L925I and T929I) in other related species.
This study indicates that resistance to bifenthrin in T. vaporariorum is associated with target-site insensitivity, and that the specific mutations in the sodium channel causing resistance may differ between localities.
Copyright © 2012 Society of Chemical Industry.
Mortality rates of three European strains of T. vaporariorum to the pyrethroid bifenthrin were calculated, and each possessed significant resistance (up to 662-fold) when compared with a susceptible reference strain. Direct sequencing revealed three amino acid substitutions in the para-type voltage-gated sodium channel (the pyrethroid and DDT target site) of bifenthrin-resistant T. vaporariorum at positions previously implicated with pyrethroid or DDT resistance (M918L, L925I and T929I) in other related species.
This study indicates that resistance to bifenthrin in T. vaporariorum is associated with target-site insensitivity, and that the specific mutations in the sodium channel causing resistance may differ between localities.
Copyright © 2012 Society of Chemical Industry.
Mutation #2
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
T929I
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | ACT | ATT | - |
| Amino-acid | Thr | Ile | 925 |
Main Reference
Authors
Karatolos N; Gorman K; Williamson MS; Denholm I
Abstract
Trialeurodes vaporariorum Westwood is an important pest of protected crops in temperate regions of the world. Resistance to pyrethroid insecticides is long established in this species, but the molecular basis of the mechanism(s) responsible has not previously been disclosed.
Mortality rates of three European strains of T. vaporariorum to the pyrethroid bifenthrin were calculated, and each possessed significant resistance (up to 662-fold) when compared with a susceptible reference strain. Direct sequencing revealed three amino acid substitutions in the para-type voltage-gated sodium channel (the pyrethroid and DDT target site) of bifenthrin-resistant T. vaporariorum at positions previously implicated with pyrethroid or DDT resistance (M918L, L925I and T929I) in other related species.
This study indicates that resistance to bifenthrin in T. vaporariorum is associated with target-site insensitivity, and that the specific mutations in the sodium channel causing resistance may differ between localities.
Copyright © 2012 Society of Chemical Industry.
Mortality rates of three European strains of T. vaporariorum to the pyrethroid bifenthrin were calculated, and each possessed significant resistance (up to 662-fold) when compared with a susceptible reference strain. Direct sequencing revealed three amino acid substitutions in the para-type voltage-gated sodium channel (the pyrethroid and DDT target site) of bifenthrin-resistant T. vaporariorum at positions previously implicated with pyrethroid or DDT resistance (M918L, L925I and T929I) in other related species.
This study indicates that resistance to bifenthrin in T. vaporariorum is associated with target-site insensitivity, and that the specific mutations in the sodium channel causing resistance may differ between localities.
Copyright © 2012 Society of Chemical Industry.
RELATED GEPHE
Related Genes
Related Haplotypes
EXTERNAL LINKS
COMMENTS
@SeveralMutationsWithEffect
YOUR FEEDBACK is welcome!