GEPHE SUMMARY Print
Gephebase Gene
Lectin-24A
Entry Status
Published
GepheID
GP00002659
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Physiology
Trait
Pathogen resistance (parasitic wasp)
Trait State in Taxon A
Drosophila melanogaster - resistant
Trait State in Taxon B
Drosophila melanogaster - lost the resistance
Ancestral State
Taxon A
Taxonomic Status
Intraspecific
Taxon A
Latin Name
Drosophila melanogaster
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
Parent
melanogaster subgroup () - (Rank: species subgroup)
NCBI Taxonomy ID
7227
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Drosophila melanogaster
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
Parent
melanogaster subgroup () - (Rank: species subgroup)
NCBI Taxonomy ID
7227
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
lectin-24A
Synonyms
AC 005149A; AC005149a; CG3410; Dmel\CG3410; lectin-24A-RA; Dmel_CG3410
String
7227.FBpp0077228
Sequence Similarities
-
GO - Molecular Function
GO:0030246 : carbohydrate binding ... show more
GO - Biological Process
GO:0016339 : calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ... show more
GO - Cellular Component
GO:0005576 : extracellular region ... show more
UniProtKB
Drosophila melanogaster
Q9VQU4
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Coding
Aberration Type
SNP
SNP Coding Change
Nonsense
Molecular Details of the Mutation
F217 >STOP - point mutation that introduces a premature stop codon
Experimental Evidence
Linkage Mapping
Taxon A Taxon B Position
Codon - - -
Amino-acid Phe STP 254
Main Reference
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite . (2022 )
Authors
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P; Bakare Sherifat; Pitton Simone; Hsing Chi-Yun; O’Boyle Sinead; Pascual-Gil Juan; et al. ... show more
Abstract
-
Additional References
RELATED GEPHE
Related Genes
15 (18-wheeler, CG8492, Diptericin, Drosomycin-like 5, Ge-1, GNBP1, GNBP2, Immune deficiency, pastrel, PGRP-LC, ref(2)P, SR-CII, Tehao, Ubiquitin conjugating enzyme E2H (Ubc-E2H), CHKov1)
Related Haplotypes
4
EXTERNAL LINKS
COMMENTS
Lectin-24A is important in the immune response that protects fruit flies against one of their main natural enemies—parasitic wasps. This immune defiance appears to be costly. Many flies carry mutated copies of this gene that are no longer functional. @BioRxiv @CRISPR
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