Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

Advanced Search

Field

Term

Summary Table

Your research retrieved 31 results.

Summary
Others

Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
Nav1.6 sodium channel	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000735	SCN8A Q9UQD0	Physiology	Ile1709Val	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D	Nav1.6 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
Nav1.7 sodium channel	Xenobiotic resistance (TTX)	4 Mutations: Coding SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000736	SCN9A Q15858	Physiology	4 mutations	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D	Nav1.7 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Mya arenaria (species) D	Intraspecific	Candidate Gene	Bricelj VM; Connell L; Konoki K ; et al. (2005) Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.	GP00000721	SCN4A P35499	Physiology	E945D	Mya arenaria (species)	Mya arenaria (species) D	SCN4A (Nav1.4)	Mya arenaria (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000724	SCN4A P35499	Physiology	G1569D in DIV domain and D1568S in DIV domain with D1568S supposed to increase the resistance - exact causing mutation(s) unknown	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D	SCN4A (Nav1.4)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Rhabdophis tigrinus Tiger keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000725	SCN4A P35499	Physiology	I1555M	Thamnophis elegans Western terrestrial garter snake - (species)	Rhabdophis tigrinus Tiger keelback - (species) D	SCN4A (Nav1.4)	Rhabdophis tigrinus Tiger keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000726	SCN4A P35499	Physiology	D1277E in DIII domain	Thamnophis couchii (species)	Thamnophis atratus (species) D	SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000727	SCN4A P35499	Physiology	D1568N in DIV domain	Thamnophis couchii (species)	Thamnophis atratus (species) D	SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis couchii (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000728	SCN4A P35499	Physiology	M1276T in DIII domain	Thamnophis atratus (species)	Thamnophis couchii (species) D	SCN4A (Nav1.4)	Thamnophis couchii (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Hebius pryeri Pryer's keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000729	SCN4A P35499	Physiology	D1227E = D945E in DIII domain	Hebius vibakari Japanese keelback - (species)	Hebius pryeri Pryer's keelback - (species) D	SCN4A (Nav1.4)	Hebius pryeri Pryer's keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000730	SCN4A P35499	Physiology	G1566A in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)	SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000731	SCN4A P35499	Physiology	I1561V in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)	SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000732	SCN4A P35499	Physiology	I1556L and/or D1568N and/or G1569V	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)	SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000722	SCN4A P35499	Physiology	Y401N	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)	SCN4A (Nav1.4a gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000723	SCN4A P35499	Physiology	Y401C	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)	SCN4A (Nav1.4a gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes. 1 Additional References Jost MC; Hillis DM; Lu Y (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000733	SCN4A P35499	Physiology	E945D	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)	SCN4A (Nav1.4b gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Jost MC; Hillis DM; Lu Y ; et al. (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000734	SCN4A P35499	Physiology	M1240T	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)	SCN4A (Nav1.4b gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Viperidae (family) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001652	SCN8A A0A1B0Z7A5	Physiology	I1709V in DIV (2x resistance)	Protobothrops flavoviridis (species)	Viperidae (family) D	SCN8A (Nav1.6)	Viperidae (family)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Micrurus fulvius eastern coral snake - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001653	SCN8A A0A1B0Z7H0	Physiology	I1709V in DIV domain (2x resistance)	Naja kaouthia monocled cobra - (species)	Micrurus fulvius eastern coral snake - (species) D	SCN8A (Nav1.6)	Micrurus fulvius eastern coral snake - (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Elapsoidea nigra (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001654	SCN8A A0A1B0Z7G3	Physiology	I1709V in DIV domain (2x resistance)	Naja kaouthia monocled cobra - (species)	Elapsoidea nigra (species) D	SCN8A (Nav1.6)	Elapsoidea nigra (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001655	SCN8A A0A1B0Z7B3	Physiology	G1717M in DIV domain (not tested)	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D	SCN8A (Nav1.6)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Lygophis anomalus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001656	SCN8A A0A1B0Z7F2	Physiology	V1709I (reversion) in DIV domain (loss of resistance)	Helicops angulatus (species)	Lygophis anomalus (species) D	SCN8A (Nav1.6)	Lygophis anomalus (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Natricinae (subfamily) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001657	SCN8A A0A1B0Z7B0	Physiology	V1709I (reversion) in DIV (loss of resistance)	Hebius pryeri Pryer's keelback - (species)	Natricinae (subfamily) D	SCN8A (Nav1.6)	Natricinae (subfamily)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Anilios bituberculatus prong-snouted blind snake - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001643	SCN9A Q15858	Physiology	M1392A in DIII domain (not tested)	Anolis carolinensis green anole - (species)	Anilios bituberculatus prong-snouted blind snake - (species) D	SCN9A (Nav1.7)	Anilios bituberculatus prong-snouted blind snake - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Henophidia (superfamily) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001644	SCN9A Q15858	Physiology	M1392T in DIII (15x resistance)	Anolis carolinensis green anole - (species)	Henophidia (superfamily) D	SCN9A (Nav1.7)	Henophidia (superfamily)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Chrysemys picta painted turtle - (species) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001645	SCN9A Q15858	Physiology	D1393P (most probably E>P) in DIII domain (not tested)	Gallus gallus chicken - (species)	Chrysemys picta painted turtle - (species) D	SCN9A (Nav1.7)	Chrysemys picta painted turtle - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Carphophis (genus) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001646	SCN9A Q15858	Physiology	I1677V in DIV (2x resistance)	Diadophis punctatus Ringneck snake - (species)	Carphophis (genus) D	SCN9A (Nav1.7)	Carphophis (genus)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Chrysemys picta painted turtle - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001647	SCN9A Q15858	Physiology	A1681G in DIV domain (1.5x resistance)	Gallus gallus chicken - (species)	Chrysemys picta painted turtle - (species) D	SCN9A (Nav1.7)	Chrysemys picta painted turtle - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Leptotyphlops (genus) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001648	SCN9A Q15858	Physiology	A1681G (1.5x resistance) in DIV	Anilios bituberculatus prong-snouted blind snake - (species)	Leptotyphlops (genus) D	SCN9A (Nav1.7)	Leptotyphlops (genus)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Anolis carolinensis green anole - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001649	SCN9A Q15858	Physiology	D1684A (most probably N>A) in DIV domain (150x resistance)	Dopasia gracilis Burmese glass lizard - (species)	Anolis carolinensis green anole - (species) D	SCN9A (Nav1.7)	Anolis carolinensis green anole - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Epicrates cenchria (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001650	SCN9A Q15858	Physiology	D1684H (most probably N>H) in DIV domain (not tested)	Boa constrictor boa - (species)	Epicrates cenchria (species) D	SCN9A (Nav1.7)	Epicrates cenchria (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Leptotyphlops (genus) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001651	SCN9A Q15858	Physiology	G1685Y (not tested) in DIV	Anilios bituberculatus prong-snouted blind snake - (species)	Leptotyphlops (genus) D	SCN9A (Nav1.7)	Leptotyphlops (genus)	Published - Accepted by Curator