Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 27 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
Agouti (ASIP)	Coloration (coat)	Cis-regulatory, Insertion	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Morgan HD; Sutherland HG; Martin DI ; et al. (1999) Epigenetic inheritance at the agouti locus in the mouse.	GP00002107	Asip Q03288	Morphology	insertion of an intra-cisternal A particle (IAP) retrotransposon upstream of the agouti gene (A). This activates transcription and causes ectopic expression of agouti protein; resulting in yellow fur; obesity; diabetes and increased susceptibility to tumours. The pleiotropic effects of ectopic agouti expression are presumably due to effects of the paracrine signal on other tissues.	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	Agouti (ASIP)	Mus musculus house mouse - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (polycyclic aromatic hydrocarbons; TCDD)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Linkage Mapping	Poland A; Palen D; Glover E (1994) Analysis of the four alleles of the murine aryl hydrocarbon receptor.	GP00001810	Ahr P30561	Physiology	alanine at position 375 mutated into valine; decreases the affinity 4-fold	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	AHR	Mus musculus house mouse - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Pajic P; Pavlidis P; Dean K ; et al. (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00001867	Amy1 P00687	Physiology	Copy Number Variation	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	amylase	Mus musculus house mouse - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Hébert JM; Rosenquist T; Götz J ; et al. (1994) FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. 1 Additional References Sundberg JP; Rourk MH; Boggess D (1997) Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin graf[...]	GP00002441	Fgf5 P15656	Morphology	Deletion which extends at least 2kb upstream of the Fgf5 translational start site and terminates at the end of the first exon or beginning of the first intron. N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	FGF5	Mus musculus house mouse - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Mizuno S; Iijima S; Okano T ; et al. (2011) Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.	GP00002442	Fgf5 P15656	Morphology	Deletion of a 9.3-kb region in the Fgf5 gene including exon 3 and its 5' and 3' flanking sequences. The genomic deletion site also shows insertion of a 498-bp early transposon element long terminal repeat. N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	FGF5	Mus musculus house mouse - (species)	Published - Accepted by Curator
Fidgetin-like1 (Fignl1)	Testis size (testis weight ; spermatogenesis)	Unknown, Unknown	Mus musculus house mouse - (species)	Interspecific	Linkage Mapping	L'Hôte D; Vatin M; Auer J ; et al. (2011) Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced tes[...]	GP00001668	Fignl1 Q8BPY9	Physiology	Several non-synonymous SNPs and an alternative splicing encoding a truncated isoform that may act as a competitor of the full length protein in the degradation process	Mus spretus western wild mouse - (species)	Mus musculus house mouse - (species)	Fidgetin-like1 (Fignl1)	Mus musculus house mouse - (species)	Published - Accepted by Curator
Glypican-3 (Gpc3)	Body size (weight)	Cis-regulatory, Unknown	Mus musculus house mouse - (species)	Domesticated	Linkage Mapping	Oliver F; Christians JK; Liu X ; et al. (2005) Regulatory variation at glypican-3 underlies a major growth QTL in mice.	GP00000407	Gpc3 Q8CFZ4	Physiology	unknown; possible 3'UTR variation	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Glypican-3 (Gpc3)	Mus musculus house mouse - (species)	Published - Accepted by Curator
GPR133	Body size (weight)	Cis-regulatory, Unknown	Mus musculus house mouse - (species)	Domesticated	Association Mapping	Chan YF; Jones FC; McConnell E ; et al. (2012) Parallel selection mapping using artificially selected mice reveals body weight control loci.	GP00000411	ADGRD1 Q6QNK2	Physiology	unknown	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	GPR133	Mus musculus house mouse - (species)	Published - Accepted by Curator
Latexin (Lxn)	Stem cell number (hematopoietic precursors)	Cis-regulatory, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Liang Y; Jansen M; Aronow B ; et al. (2007) The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in[...]	GP00000534	Lxn P70202	Morphology	Not identified	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Latexin (Lxn)	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000582	MC1R Q01726	Morphology	1bp deletion at 183; frameshift & premature stop N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus poschiavinus (species)	Interspecific	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000583	MC1R Q01726	Morphology	S69L	Mus musculus house mouse - (species)	Mus poschiavinus (species)	MC1R	Mus poschiavinus (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000584	MC1R Q01726	Morphology	E92K	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000585	MC1R Q01726	Morphology	L98P	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Wada A; Kunieda T; Nishimura M ; et al. (2005 Mar-Apr) A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred s[...]	GP00000586	MC1R Q01726	Morphology	W252C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Rattus norvegicus Norway rat - (species) D Mus musculus house mouse - (species) D Mesocricetus auratus golden hamster - (species) D Peromyscus maniculatus North American deer mouse - (species) D Nannospalax galili Upper Galilee mountains blind mole rat - (species) D	Intergeneric or Higher	Candidate Gene	Shull GE; Greeb J; Lingrel JB (1986) Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00001739	Atp1a1 Q8VDN2	Physiology	2 mutations	Jaculus jaculus lesser Egyptian jerboa - (species) Spermophilus old world ground squirrels - (genus)	Rattus norvegicus Norway rat - (species) D Mus musculus house mouse - (species) D Mesocricetus auratus golden hamster - (species) D Peromyscus maniculatus North American deer mouse - (species) D Nannospalax galili Upper Galilee mountains blind mole rat - (species) D	Na/K-ATPase alpha-subunit	Rattus norvegicus Norway rat - (species) Mus musculus house mouse - (species) Mesocricetus auratus golden hamster - (species) Peromyscus maniculatus North American deer mouse - (species) Nannospalax galili Upper Galilee mountains blind mole rat - (species)	Published - Accepted by Curator
PMEL17	Coloration (coat)	Coding, Insertion	Mus musculus house mouse - (species) D	Domesticated	Linkage Mapping	Kwon BS; Halaban R; Ponnazhagan S ; et al. (1995) Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pme[...]	GP00002101	Pmel Q60696	Morphology	single nucleotide (A) insertion in the putative cytoplasmic tail of the si/si Pmel 17 cDNA clone. This insertion is predicted to alter the last 24 amino acids at the C-terminus. Also predicted is the extension of the Pmel 17 protein by 12 residues because a new termination signal is created downstream from the wild-type reading frame. The silver pmel 17 protein has a major defect at the carboxyl terminus.	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	PMEL17	Mus musculus house mouse - (species)	Published - Accepted by Curator
Prdm9	Hybrid incompatibility (F1 male sterility) Recombination rate (use of recombination hotspots)	Unknown, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Mihola O; Trachtulec Z; Vlcek C ; et al. (2009) A mouse speciation gene encodes a meiotic histone H3 methyltransferase. 2 Additional References Baudat F; Buard J; Grey C (2010) PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Flachs P; Mihola O; Simeček P (2012) Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.	GP00000922	Prdm9 Q96EQ9	Physiology Physiology	possible dosage difference (number of gene copies) interacting with an allele that affects post-transcriptional stability	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Prdm9	Mus musculus house mouse - (species)	Published - Accepted by Curator
Prolactin releasing hormone receptor (Prlhr/GPR10)	Body size (weight)	Cis-regulatory, Unknown	Mus musculus house mouse - (species)	Domesticated	Association Mapping	Chan YF; Jones FC; McConnell E ; et al. (2012) Parallel selection mapping using artificially selected mice reveals body weight control loci.	GP00000928	PRLHR P49683	Physiology	unknown	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Prolactin releasing hormone receptor (Prlhr/GPR10)	Mus musculus house mouse - (species)	Published - Accepted by Curator
Prx1 = Mhox = Prrx1	Limb length	Cis-regulatory, Unknown	Carollia perspicillata Seba's short-tailed bat - (species)	Intergeneric or Higher	Candidate Gene	Cretekos CJ; Wang Y; Green ED ; et al. (2008) Regulatory divergence modifies limb length between mammals.	GP00000934	Prrx1 P63013	Morphology	Not identified	Mus musculus house mouse - (species)	Carollia perspicillata Seba's short-tailed bat - (species)	Prx1 = Mhox = Prrx1	Carollia perspicillata Seba's short-tailed bat - (species)	Published - Accepted by Curator
Ptch1	Limb morphology (skeleton)	Cis-regulatory, Unknown	Bos taurus cattle - (species) D	Intergeneric or Higher	Candidate Gene	Lopez-Rios J; Duchesne A; Speziale D ; et al. (2014) Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.	GP00001389	Ptch1 Q61115	Morphology	LRM enhancer located between coding exons 15 and 19 at 37 kb of the transcription start site - exact causing mutation(s) unknown - Loss of activity of the LRM enhancer that normally upregulates Ptch1 expression in the limb-bud mesenchyme in response to SHH signalling	Mus musculus house mouse - (species)	Bos taurus cattle - (species) D	Ptch1	Bos taurus cattle - (species)	Published - Accepted by Curator
Regulator of G-protein signaling 2 (RGS2)	Anxiety	Unknown, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Yalcin B; Willis-Owen SA; Fullerton J ; et al. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mic[...]	GP00000967	Rgs2 O08849	Behavior	unknown	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Regulator of G-protein signaling 2 (RGS2)	Mus musculus house mouse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (eyes; fur)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Linkage Mapping	Du J; Fisher DE (2002) Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF.	GP00001060	SLC45A2 Q9UMX9	Morphology	N153D	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	SLC45A2=MATP	Mus musculus house mouse - (species)	Published - Accepted by Curator
TAS1R3	Taste sensitivity (sugar)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Max M; Shanker YG; Huang L ; et al. (2001) Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. 1 Additional References Montmayeur JP; Liberles SD; Matsunami H (2001) A candidate taste receptor gene near a sweet taste locus.	GP00001110	TAS1R3 Q7RTX0	Physiology	I60T; is predicted to introduce a novel N-linked glycosylation site which might interfere with receptor dimerization	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	TAS1R3	Mus musculus house mouse - (species)	Published - Accepted by Curator
Ubiquitin-specific peptidase 46 (Usp46)	Escape behavior (immobility in inescapable situations)	Coding, Deletion	Mus musculus house mouse - (species) D	Intraspecific	Linkage Mapping	Tomida S; Mamiya T; Sakamaki H ; et al. (2009) Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and for[...]	GP00001159	Usp46 P62069	Behavior	1a.a. deletion	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	Ubiquitin-specific peptidase 46 (Usp46)	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001172	VKORC1 Q9BQB6	Physiology	L128S	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Vkorc1	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001173	VKORC1 Q9BQB6	Physiology	Y139C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Vkorc1	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus spretus western wild mouse - (species)	Intraspecific	Candidate Gene	Song Y; Endepols S; Klemann N ; et al. (2011) Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world [...]	GP00001174	VKORC1 Q9BQB6	Physiology	Several candidate coding changes	Mus musculus house mouse - (species)	Mus spretus western wild mouse - (species)	Vkorc1	Mus spretus western wild mouse - (species)	Published - Accepted by Curator