Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 10 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	6 Mutations:	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Choudhary M; Laurie CC (1991) Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...] 4 Additional References Laurie CC; Bridgham JT; Choudhary M (1991) Associations between DNA sequence variation and variation in expression of the Adh gene in natural p[...] King EG; Merkes CM; McNeil CL (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource. Siddiq MA; Loehlin DW; Montooth KL (2017) Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaste[...] Loehlin DW; Ames JR; Vaccaro K (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001962	Adh P00334	Physiology	6 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila yakuba (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001963	Adh P00334	Physiology	4 mutations	Drosophila santomea (species)	Drosophila yakuba (species)	alcohol dehydrogenase (Adh)	Drosophila yakuba (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila erecta (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001964	Adh P00334	Physiology	4 mutations	Drosophila orena (species)	Drosophila erecta (species)	alcohol dehydrogenase (Adh)	Drosophila erecta (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	5 Mutations:	Drosophila virilis (species) D	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001965	Adh P00334	Physiology	5 mutations	Drosophila americana (species)	Drosophila virilis (species) D	alcohol dehydrogenase (Adh)	Drosophila virilis (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Vigue C; Sofer W (1974) Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.	GP00001988	Adh P00334	Physiology	Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Strand DJ; McDonald JF (1989) Insertion of a copia element 5' to the Drosophila melanogaster alcohol dehydrogenase gene (adh) is a[...]	GP00001989	Adh P00334	Physiology	insertion of a complete 5.2kb copia retroviral-like transposable element 240 bp upstream from the distal (adult) adh transcriptional start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Freeth AL; Gibson JB; Wilks AV (1990) Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...] 1 Additional References Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001990	Adh P00334	Physiology	eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001991	Adh P00334	Physiology	438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)	Xenobiotic resistance (alcohol)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Li H; Mukherjee N; Soundararajan U ; et al. (2007) Geographically separate increases in the frequency of the derived ADH1B47His allele in eastern and [...] 1 Additional References Li H; Mukherjee N; Soundararajan U (2007)* Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]	GP00000077	ADH1B P00325	Physiology	Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication	Homo sapiens human - (species)	Homo sapiens human - (species) D	alcohol dehydrogenase (ADH1B)	Homo sapiens human - (species)	Published - Accepted by Curator
Aldehyde dehydrogenase (Aldh)	Xenobiotic resistance (alcohol)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Fry JD; Donlon K; Saweikis M (2008) A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selectio[...]	GP00002007	Aldh Q9VLC5	Physiology	L479F C9391311T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Aldehyde dehydrogenase (Aldh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator