Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 24 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Berryere TG; Schmutz SM; Schimpf RJ ; et al. (2003) TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?	GP00001145	Tyrp1 P07147	Morphology	c.1300C>T p.H434Y	Bos taurus cattle - (species)	Bos taurus cattle - (species)	tyrosinase-related protein 1 (TYRP1)	Bos taurus cattle - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Deletion	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs.	GP00001146	Tyrp1 P07147	Morphology	deletion of a proline residue in exon 5 (345delP)	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs.	GP00001147	Tyrp1 P07147	Morphology	premature stop codon in exon 5 (Q331ter) N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001149	Tyrp1 P07147	Morphology	Ala23Pro	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D	tyrosinase-related protein 1 (TYRP1)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP N	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001150	Tyrp1 P07147	Morphology	Arg72* N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D	tyrosinase-related protein 1 (TYRP1)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, Deletion N	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001151	Tyrp1 P07147	Morphology	7-bp deletion 411-418del resulting in null allele N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D	tyrosinase-related protein 1 (TYRP1)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Nadeau NJ; Mundy NI; Gourichon D ; et al. (2007) Association of a single-nucleotide substitution in TYRP1 with roux in Japanese quail (Coturnix japon[...]	GP00001152	Tyrp1 P07147	Morphology	Phe282Ser	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)	tyrosinase-related protein 1 (TYRP1)	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Schmidt-Küntzel A; Eizirik E; O'Brien SJ ; et al. (2005 Jul-Aug) Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of th[...] 1 Additional References Lyons LA; Foe IT; Rah HC (2005) Chocolate coated cats: TYRP1 mutations for brown color in domestic cats.	GP00001153	Tyrp1 P07147	Morphology	premature UAG stop codon at position 100 of TYRP1; AAG>TAG c.298C>T p.R100* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	tyrosinase-related protein 1 (TYRP1)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Unknown	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Schmidt-Küntzel A; Eizirik E; O'Brien SJ ; et al. (2005 Jul-Aug) Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of th[...]	GP00001154	Tyrp1 P07147	Morphology	Two mutations associated with the chocolate (b) allele - one leading to a TYRP1-A3G substitution in the signal peptide and another to an in-frame insertion TYRP1-421ins17/18 caused by a donor splice site mutation in intron 6 -exact causing change unknown	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	tyrosinase-related protein 1 (TYRP1)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Kenny EE; Timpson NJ; Sikora M ; et al. (2012) Melanesian blond hair is caused by an amino acid change in TYRP1.	GP00001155	Tyrp1 P07147	Morphology	R93C	Homo sapiens human - (species)	Homo sapiens human - (species) D	tyrosinase-related protein 1 (TYRP1)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Gratten J; Beraldi D; Lowder BV ; et al. (2007) Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour po[...]	GP00001156	Tyrp1 P07147	Morphology	c. 869G>T p.C290F ; Cys residue involved shows a high degree of evolutionary conservation; it is conserved not only across vertebrates but also in the two paralogues of TYRP1, DCT and TYR	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (eyes; hair; skin)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Frudakis T; Thomas M; Gaskin Z ; et al. (2003) Sequences associated with human iris pigmentation. 1 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2008) Two newly identified genetic determinants of pigmentation in Europeans.	GP00001157	Tyrp1 P07147	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	tyrosinase-related protein 1 (TYRP1)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Deletion	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Candidate Gene	Wu X; Zhang Y; Shen L ; et al. (2016) A 6-bp deletion in exon 8 and two mutations in introns of TYRP1 are associated with blond coat color[...]	GP00001327	Tyrp1 P07147	Morphology	g.17599_17604del 6bp deletion in exon 8 resulting in deletion of Met and Gly residues at positions 495 and 496 in TYRP1 protein ; c.1484_1489del6 p.Met495_Gly496del	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D	tyrosinase-related protein 1 (TYRP1)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Li J; Bed'hom B; Marthey S ; et al. (2019) A missense mutation in TYRP1 causes the chocolate plumage color in chicken and alters melanosome str[...]	GP00002126	Tyrp1 P07147	Morphology	g.30830367C>A c.640C>A p.His214Asn	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)	tyrosinase-related protein 1 (TYRP1)	Gallus gallus chicken - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs.	GP00002233	Tyrp1 P07147	Morphology	c.121T>A p.Cys41Ser	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Hrckova Turnova E; Majchrakova Z; Bielikova M ; et al. (2017) A novel mutation in the TYRP1 gene associated with brown coat colour in the Australian Shepherd Dog [...]	GP00002234	Tyrp1 P07147	Morphology	c.555T>G p.Tyr185* N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Wright HE; Schofield E; Mellersh CS ; et al. (2019) A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers.	GP00002235	Tyrp1 P07147	Morphology	c.1025T>G p.Phe342Cys	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Capra hircus goat - (species) D	Domesticated	Candidate Gene	Becker D; Otto M; Ammann P ; et al. (2015) The brown coat colour of Coppernecked goats is associated with a non-synonymous variant at the TYRP1[...]	GP00002236	Tyrp1 P07147	Morphology	c.1487G>A p.Gly496Asp	Capra hircus goat - (species)	Capra hircus goat - (species) D	tyrosinase-related protein 1 (TYRP1)	Capra hircus goat - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Raadsma HW; Jonas E; Fleet MR ; et al. (2013) QTL and association analysis for skin and fibre pigmentation in sheep provides evidence of a major c[...]	GP00002237	Tyrp1 P07147	Morphology	c.2240C>G p.A746V	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Paris JM; Letko A; Häfliger IM ; et al. (2019) Identification of two TYRP1 loss-of-function alleles in Valais Red sheep.	GP00002238	Tyrp1 P07147	Morphology	c.86_87delGA p.(Glu29ValfsTer5) N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Paris JM; Letko A; Häfliger IM ; et al. (2019) Identification of two TYRP1 loss-of-function alleles in Valais Red sheep.	GP00002239	Tyrp1 P07147	Morphology	c.1066C>T p.(Arg356*) N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Linkage Mapping	Utzeri VJ; Ribani A; Fontanesi L (2014) A premature stop codon in the TYRP1 gene is associated with brown coat colour in the European rabbit[...]	GP00002240	Tyrp1 P07147	Morphology	c.570G>A p.Trp190ter N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	tyrosinase-related protein 1 (TYRP1)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Cis-regulatory, Insertion N	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Cirera S; Markakis MN; Kristiansen T ; et al. (2016) A large insertion in intron 2 of the TYRP1 gene associated with American Palomino phenotype in Ameri[...]	GP00002241	Tyrp1 P07147	Morphology	Large insertion in intron 2 resulting in aberrant transcript N	Neovison vison American mink - (species)	Neovison vison American mink - (species) D	tyrosinase-related protein 1 (TYRP1)	Neovison vison American mink - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, Insertion N	Falco cherrug Saker falcon - (species) D	Intraspecific	Candidate Gene	Cortimiglia C; Castiglioni B; Pizzi F ; et al. (2017) Involvement of tyrosinase-related protein 1 gene in the light brown plumage phenotype of Falco cherr[...]	GP00002285	Tyrp1 P07147	Morphology	c.79_80insT in exon 1 resulting in a frameshift change and a premature stop codon at position 81 of the deduced protein sequence ; which in the wild-type form contains 536 amino acids N	Falco cherrug Saker falcon - (species)	Falco cherrug Saker falcon - (species) D	tyrosinase-related protein 1 (TYRP1)	Falco cherrug Saker falcon - (species)	Published - Accepted by Curator