cyp6g1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Schlenke TA; Begun DJ (2004)
Strong selective sweep associated with a transposon insertion in Drosophila simulans.
GP00002019
Cyp6g1
Q9V674
Physiology
insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene
Drosophila simulans
(species)
Drosophila simulans
(species) D
cyp6g1
Drosophila simulans
(species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013)
Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]
GP00002020
Cyp6g1
Q9V674
Physiology
insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene
Drosophila simulans
(species)
Drosophila simulans
(species) D
cyp6g1
Drosophila simulans
(species)
Published - Accepted by Curator
cytochrome c oxidase (COX7A)
Fertility
Lifespan
Locomotor activity
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Melvin RG; Katewa SD; Ballard JW (2008)
A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...]
1 Additional References
GP00001980
COX7A
Q9VHS2
Physiology
Physiology
Physiology
Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.
Drosophila simulans
(species)
Drosophila simulans
(species) D
cytochrome c oxidase (COX7A)
Drosophila simulans
(species)
Published - Accepted by Curator
Diptericin
Pathogen resistance (bacteria)
Coding,
SNP
Drosophila simulans
(species)
Intraspecific
Candidate Gene
Unckless RL; Howick VM; Lazzaro BP (2016)
Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.
1 Additional References
GP00000228
DptA
P24492
Physiology
Ser>Arg (AGC>AGG)
Drosophila simulans
(species)
Drosophila simulans
(species)
Diptericin
Drosophila simulans
(species)
Published - Accepted by Curator
Distorter on the X (Dox)
Sex determination (sex ratio distortion)
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Tao Y; Araripe L; Kingan SB ; et al. (2007)
A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.
GP00001969
Physiology
Deletion of 105bp, resulting in the loss of exon III, which deletes one of the 42bp elements that is tandemly repeated in wild-type Dsim\Dox.
Drosophila simulans
(species)
Drosophila simulans
(species) D
Distorter on the X (Dox)
Drosophila simulans
(species)
Published - Accepted by Curator
Fas2
Pupation site choice
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Pischedda A; Shahandeh MP; Turner TL (2020)
The Loci of Behavioral Evolution: Evidence That Fas2 and tilB Underlie Differences in Pupation Site [...]
GP00002345
Fas2
P34082
Behavior
Gene identified via deficiency mapping. RNAi in D. melanogaster leads to pupae pupating closer to the food.
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Fas2
Drosophila simulans
(species)
Published - Accepted by Curator
gfzf
Hybrid incompatibility (F1 male lethality)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Phadnis N; Baker EP; Cooper JC ; et al. (2015)
An essential cell cycle regulation gene causes hybrid inviability in Drosophila.
GP00000392
gfzf
Q6NP69
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
gfzf
Drosophila simulans
(species)
Published - Accepted by Curator
HP1D2
Sex determination (sex ratio distortion)
Coding,
Deletion
N
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Helleu Q; Gérard PR; Dubruille R ; et al. (2016)
Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.
GP00001467
HP1D2
B4R6K0
Physiology
deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N
Drosophila simulans
(species)
Drosophila simulans
(species) D
HP1D2
Drosophila simulans
(species)
Published - Accepted by Curator
Hybrid male rescue
Hybrid incompatibility (F1 male lethality)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Brideau NJ; Flores HA; Wang J ; et al. (2006)
Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.
GP00000495
Hmr
Q86CW5
Physiology
Rapid coding divergence
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Hybrid male rescue
Drosophila simulans
(species)
Published - Accepted by Curator
InR
Fertility (ovariole number)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Green DA; Extavour CG (2012)
Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...]
1 Additional References
GP00000500
InR
P09208
Physiology
unknown; loss of function reduces ovariole number
Drosophila sechellia
(species)
Drosophila simulans
(species)
InR
Drosophila simulans
(species)
Published - Accepted by Curator
JYalpha
Hybrid incompatibility (F2 male sterility)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Masly JP; Jones CD; Noor MA ; et al. (2006)
Gene transposition as a cause of hybrid sterility in Drosophila.
GP00000508
JYalpha
A8QI34
Physiology
Gene transposition
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
JYalpha
Drosophila simulans
(species)
Published - Accepted by Curator
Lethal Hybrid rescue
Hybrid incompatibility (F1 male lethality)
Coding,
Insertion
Drosophila simulans
(species) D
Interspecific
Linkage Mapping
Brideau NJ; Flores HA; Wang J ; et al. (2006)
Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.
2 Additional References
GP00000540
Lhr
Q95RV3
Physiology
16a.a. insertion with effect in sensitive background only (Maheshwari and Barbash 2012)
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species) D
Lethal Hybrid rescue
Drosophila simulans
(species)
Published - Accepted by Curator
Lethal Hybrid rescue
Hybrid incompatibility (F1 male lethality)
Coding,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Maheshwari S; Barbash DA (2012)
An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]
GP00000541
Lhr
Q95RV3
Physiology
Coding divergence in a conserved stretch of 10 C-terminal amino-acids
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Lethal Hybrid rescue
Drosophila simulans
(species)
Published - Accepted by Curator
mitochondrial tyrosine tRNA
Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013)
An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...]
1 Additional References
GP00001971
Physiology
C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)
Drosophila simulans
(species)
Drosophila simulans
(species) D
mitochondrial tyrosine tRNA
Drosophila simulans
(species)
Published - Accepted by Curator
Not much yang (Nmy)
Sex determination (sex ratio distortion)
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Tao Y; Masly JP; Araripe L ; et al. (2007)
A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor.
1 Additional References
GP00001970
Physiology
Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus and loss of most of the sequence located between the inverted repeats (except for a 93bp element in reverse orientation).
Drosophila simulans
(species)
Drosophila simulans
(species) D
Not much yang (Nmy)
Drosophila simulans
(species)
Published - Accepted by Curator
Nup160
Hybrid incompatibility (F1 male sterility)
Coding,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Tang S; Presgraves DC (2009)
Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.
GP00000742
Nup160
Q9VKJ3
Physiology
Coding divergence
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Nup160
Drosophila simulans
(species)
Published - Accepted by Curator
Nup96
Hybrid incompatibility (F1 male sterility)
Coding,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Presgraves DC; Balagopalan L; Abmayr SM ; et al. (2003)
Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.
GP00000743
NUP96
Q8LLD0
Physiology
Coding divergence
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Nup96
Drosophila simulans
(species)
Published - Accepted by Curator
Odysseus-site homeobox
Hybrid incompatibility (F1 male sterility)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Bayes JJ; Malik HS (2009)
Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species.
GP00000752
OdsH
Q9VX20
Physiology
Rapid coding divergence
Drosophila mauritiana
(species)
Drosophila simulans
(species)
Odysseus-site homeobox
Drosophila simulans
(species)
Published - Accepted by Curator
Or22a
Olfaction
Coding,
SNP
Drosophila sechellia
(species) D
Drosophila simulans
(species) D
Drosophila mauritiana
(species) D
Interspecific
Candidate Gene
Auer TO; Khallaf MA; Silbering AF ; et al. (2020)
Olfactory receptor and circuit evolution promote host specialization.
GP00002183
Or22a
P81909
Physiology
Effect of the mutation tested in a Or22a construct which rescues the Or22a knock-down mutation in D. melanogaster.There are two other amino acid changes that may have an effect as well.
Drosophila melanogaster
fruit fly - (species)
Drosophila sechellia
(species) D
Drosophila simulans
(species) D
Drosophila mauritiana
(species) D
Or22a
Drosophila sechellia
(species)
Drosophila simulans
(species)
Drosophila mauritiana
(species)
Published - Accepted by Curator
Period (per)
Courtship song
Coding,
SNP
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Wheeler DA; Kyriacou CP; Greenacre ML ; et al. (1991)
Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaste[...]
3 Additional References
GP00000860
per
P07663
Behavior
A121T and/or K125R and/or E165D and /or V224A
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Period (per)
Drosophila simulans
(species)
Published - Accepted by Curator
prophenoloxidase 3 (PPO3)
Immune response (melanotic encapsulation by lamellocytes)
Coding,
SNP
N
Drosophila sechellia
(species) D
Interspecific
Candidate Gene
Dudzic JP; Kondo S; Ueda R ; et al. (2015)
Drosophila innate immunity: regional and functional specialization of prophenoloxidases.
GP00001781
PPO3
Q9W1V6
Physiology
amino acid change at position 48 which converts the terminal glutamine residue of the propeptide region to a stop codon, and is predicted to generate a truncated version of the PPO3 protein N
Drosophila simulans
(species)
Drosophila mauritiana
(species)
Drosophila sechellia
(species) D
prophenoloxidase 3 (PPO3)
Drosophila sechellia
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Lee HJ; Rocheleau T; Zhang HG ; et al. (1993)
Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...]
1 Additional References
GP00000975
Rdl
P25123
Physiology
Ala302Ser
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Lee HJ; Rocheleau T; Zhang HG ; et al. (1993)
Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...]
1 Additional References
GP00000976
Rdl
P25123
Physiology
Ala302Gly
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Le Goff G; Hamon A; Bergé JB ; et al. (2005)
Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]
GP00001981
Rdl
P25123
Physiology
2 mutations
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
slowpoke (slo)
Courtship song (sine song frequency)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Ding Y; Berrocal A; Morita T ; et al. (2016)
Natural courtship song variation caused by an intronic retroelement in an ion channel gene.
GP00001066
slo
Q03720
Behavior
6.7kb "Shelder" retroelement insertion in slowpoke intron; with effect on splicing
Drosophila simulans
(species)
Drosophila simulans
(species) D
slowpoke (slo)
Drosophila simulans
(species)
Published - Accepted by Curator
Svb/ovo
Trichome pattern (larva)
9 Mutations:
Cis-regulatory
Drosophila sechellia
(species) D
Interspecific
Linkage Mapping
McGregor AP; Orgogozo V; Delon I ; et al. (2007)
Morphological evolution through multiple cis-regulatory mutations at a single gene.
1 Additional References
GP00001085
ovo
P51521
Morphology
9 mutations
Drosophila simulans
(species)
Drosophila mauritiana
(species)
Drosophila sechellia
(species) D
Svb/ovo
Drosophila sechellia
(species)
Published - Accepted by Curator
tartan
Organ size (genitalia; clasper)
Bristle number (genitalia; clasper)
Cis-regulatory,
Unknown
Drosophila mauritiana
(species) D
Interspecific
Linkage Mapping
Hagen JFD; Mendes CC; Blogg A ; et al. (2019)
tartan underlies the evolution of Drosophila male genital morphology.
GP00002047
trn
Q9VU51
Morphology
Morphology
no coding changes
Drosophila simulans
(species)
Drosophila mauritiana
(species) D
tartan
Drosophila mauritiana
(species)
Published - Accepted by Curator
touch insensitive larva B (tilB)
Pupation site choice
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Pischedda A; Shahandeh MP; Turner TL (2020)
The Loci of Behavioral Evolution: Evidence That Fas2 and tilB Underlie Differences in Pupation Site [...]
GP00002344
tilB
Q9VR52
Behavior
Gene identified via deficiency mapping. Gene more highly expressed in D. melanogaster than in D. simulans. RNAi in D. melanogaster leads to pupae pupating closer to the food.
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
touch insensitive larva B (tilB)
Drosophila simulans
(species)
Published - Accepted by Curator
Ultrabithorax (Ubx)
Trichome pattern (leg)
Cis-regulatory,
Unknown
Drosophila simulans
(species)
Interspecific
Candidate Gene
Stern DL (1998)
A role of Ultrabithorax in morphological differences between Drosophila species.
GP00001161
Ubx
P83949
Morphology
Not identified
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Ultrabithorax (Ubx)
Drosophila simulans
(species)
Published - Accepted by Curator
Zygotic hybrid rescue
F1 lethality (female-limited)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Ferree PM; Barbash DA (2009)
Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality i[...]
GP00001228
Physiology
Heterochromatin incompatibilitity
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Zygotic hybrid rescue
Drosophila simulans
(species)
Published - Accepted by Curator