Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 28 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Schlenke TA; Begun DJ (2004) Strong selective sweep associated with a transposon insertion in Drosophila simulans.	GP00002019	Cyp6g1 Q9V674	Physiology	insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D	cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013) Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]	GP00002020	Cyp6g1 Q9V674	Physiology	insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D	cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
cytochrome c oxidase (COX7A)	Fertility Lifespan Locomotor activity	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Melvin RG; Katewa SD; Ballard JW (2008) A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...] 1 Additional References Ballard JW; Melvin RG (2011) Early life benefits and later life costs of a two amino acid deletion in Drosophila simulans.	GP00001980	COX7A Q9VHS2	Physiology Physiology Physiology	Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.	Drosophila simulans (species)	Drosophila simulans (species) D	cytochrome c oxidase (COX7A)	Drosophila simulans (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila. 1 Additional References Unckless RL; Lazzaro BP (2016) The potential for adaptive maintenance of diversity in insect antimicrobial peptides.	GP00000228	DptA P24492	Physiology	Ser>Arg (AGC>AGG)	Drosophila simulans (species)	Drosophila simulans (species)	Diptericin	Drosophila simulans (species)	Published - Accepted by Curator
Distorter on the X (Dox)	Sex determination (sex ratio distortion)	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Tao Y; Araripe L; Kingan SB ; et al. (2007) A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.	GP00001969		Physiology	Deletion of 105bp, resulting in the loss of exon III, which deletes one of the 42bp elements that is tandemly repeated in wild-type Dsim\Dox.	Drosophila simulans (species)	Drosophila simulans (species) D	Distorter on the X (Dox)	Drosophila simulans (species)	Published - Accepted by Curator
gfzf	Hybrid incompatibility (F1 male lethality)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Phadnis N; Baker EP; Cooper JC ; et al. (2015) An essential cell cycle regulation gene causes hybrid inviability in Drosophila.	GP00000392	gfzf Q6NP69	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	gfzf	Drosophila simulans (species)	Published - Accepted by Curator
HP1D2	Sex determination (sex ratio distortion)	Coding, Deletion N	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Helleu Q; Gérard PR; Dubruille R ; et al. (2016) Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.	GP00001467	HP1D2 B4R6K0	Physiology	deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N	Drosophila simulans (species)	Drosophila simulans (species) D	HP1D2	Drosophila simulans (species)	Published - Accepted by Curator
Hybrid male rescue	Hybrid incompatibility (F1 male lethality)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Brideau NJ; Flores HA; Wang J ; et al. (2006) Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.	GP00000495	Hmr Q86CW5	Physiology	Rapid coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Hybrid male rescue	Drosophila simulans (species)	Published - Accepted by Curator
InR	Fertility (ovariole number)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Green DA; Extavour CG (2012) Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...] 1 Additional References Orgogozo V; Broman KW; Stern DL (2006) High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number [...]	GP00000500	InR P09208	Physiology	unknown; loss of function reduces ovariole number	Drosophila sechellia (species)	Drosophila simulans (species)	InR	Drosophila simulans (species)	Published - Accepted by Curator
JYalpha	Hybrid incompatibility (F2 male sterility)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Masly JP; Jones CD; Noor MA ; et al. (2006) Gene transposition as a cause of hybrid sterility in Drosophila.	GP00000508	JYalpha A8QI34	Physiology	Gene transposition	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	JYalpha	Drosophila simulans (species)	Published - Accepted by Curator
Lethal Hybrid rescue	Hybrid incompatibility (F1 male lethality)	Coding, Insertion	Drosophila simulans (species) D	Interspecific	Linkage Mapping	Brideau NJ; Flores HA; Wang J ; et al. (2006) Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. 2 Additional References Nolte V; Weigel D; Schlötterer C (2008) The impact of shared ancestral variation on hybrid male lethality--a 16 codon indel in the Drosophil[...] Maheshwari S; Barbash DA (2012) An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]	GP00000540	Lhr Q95RV3	Physiology	16a.a. insertion with effect in sensitive background only (Maheshwari and Barbash 2012)	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species) D	Lethal Hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator
Lethal Hybrid rescue	Hybrid incompatibility (F1 male lethality)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Maheshwari S; Barbash DA (2012) An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]	GP00000541	Lhr Q95RV3	Physiology	Coding divergence in a conserved stretch of 10 C-terminal amino-acids	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Lethal Hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator
mitochondrial tyrosine tRNA	Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013) An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...] 1 Additional References Hoekstra LA; Siddiq MA; Montooth KL (2013) Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect o[...]	GP00001971		Physiology	C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)	Drosophila simulans (species)	Drosophila simulans (species) D	mitochondrial tyrosine tRNA	Drosophila simulans (species)	Published - Accepted by Curator
Not much yang (Nmy)	Sex determination (sex ratio distortion)	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Tao Y; Masly JP; Araripe L ; et al. (2007) A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor. 1 Additional References Tao Y; Araripe L; Kingan SB (2007) A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.	GP00001970		Physiology	Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus and loss of most of the sequence located between the inverted repeats (except for a 93bp element in reverse orientation).	Drosophila simulans (species)	Drosophila simulans (species) D	Not much yang (Nmy)	Drosophila simulans (species)	Published - Accepted by Curator
Nup160	Hybrid incompatibility (F1 male sterility)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Tang S; Presgraves DC (2009) Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.	GP00000742	Nup160 Q9VKJ3	Physiology	Coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Nup160	Drosophila simulans (species)	Published - Accepted by Curator
Nup96	Hybrid incompatibility (F1 male sterility)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Presgraves DC; Balagopalan L; Abmayr SM ; et al. (2003) Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.	GP00000743	NUP96 Q8LLD0	Physiology	Coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Nup96	Drosophila simulans (species)	Published - Accepted by Curator
Odysseus-site homeobox	Hybrid incompatibility (F1 male sterility)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Bayes JJ; Malik HS (2009) Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species.	GP00000752	OdsH Q9VX20	Physiology	Rapid coding divergence	Drosophila mauritiana (species)	Drosophila simulans (species)	Odysseus-site homeobox	Drosophila simulans (species)	Published - Accepted by Curator
Or22a	Olfaction	Coding, SNP	Drosophila sechellia (species) D Drosophila simulans (species) D Drosophila mauritiana (species) D	Interspecific	Candidate Gene	Auer TO; Khallaf MA; Silbering AF ; et al. (2020) Olfactory receptor and circuit evolution promote host specialization.	GP00002183	Or22a P81909	Physiology	Effect of the mutation tested in a Or22a construct which rescues the Or22a knock-down mutation in D. melanogaster.There are two other amino acid changes that may have an effect as well.	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D Drosophila simulans (species) D Drosophila mauritiana (species) D	Or22a	Drosophila sechellia (species) Drosophila simulans (species) Drosophila mauritiana (species)	Published - Accepted by Curator
Period (per)	Courtship song	Coding, SNP	Drosophila simulans (species)	Interspecific	Linkage Mapping	Wheeler DA; Kyriacou CP; Greenacre ML ; et al. (1991) Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaste[...] 3 Additional References Kyriacou CP; Hall JC (1986) Interspecific genetic control of courtship song production and reception in Drosophila. Kyriacou CP; Green EW; Piffer A (2017) Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detec[...] Stern DL (2014) Reported Drosophila courtship song rhythms are artifacts of data analysis.	GP00000860	per P07663	Behavior	A121T and/or K125R and/or E165D and /or V224A	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Period (per)	Drosophila simulans (species)	Published - Accepted by Curator
prophenoloxidase 3 (PPO3)	Immune response (melanotic encapsulation by lamellocytes)	Coding, SNP N	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Dudzic JP; Kondo S; Ueda R ; et al. (2015) Drosophila innate immunity: regional and functional specialization of prophenoloxidases.	GP00001781	PPO3 Q9W1V6	Physiology	amino acid change at position 48 which converts the terminal glutamine residue of the propeptide region to a stop codon, and is predicted to generate a truncated version of the PPO3 protein N	Drosophila simulans (species) Drosophila mauritiana (species)	Drosophila sechellia (species) D	prophenoloxidase 3 (PPO3)	Drosophila sechellia (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Rdl P25123	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Le Goff G; Hamon A; Bergé JB ; et al. (2005) Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]	GP00001981	Rdl P25123	Physiology	2 mutations	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
slowpoke (slo)	Courtship song (sine song frequency)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Ding Y; Berrocal A; Morita T ; et al. (2016) Natural courtship song variation caused by an intronic retroelement in an ion channel gene.	GP00001066	slo Q03720	Behavior	6.7kb "Shelder" retroelement insertion in slowpoke intron; with effect on splicing	Drosophila simulans (species)	Drosophila simulans (species) D	slowpoke (slo)	Drosophila simulans (species)	Published - Accepted by Curator
Svb/ovo	Trichome pattern (larva)	9 Mutations: Cis-regulatory	Drosophila sechellia (species) D	Interspecific	Linkage Mapping	McGregor AP; Orgogozo V; Delon I ; et al. (2007) Morphological evolution through multiple cis-regulatory mutations at a single gene. 1 Additional References Preger-Ben Noon E; Davis FP; Stern DL (2016) Evolved Repression Overcomes Enhancer Robustness.	GP00001085	ovo P51521	Morphology	9 mutations	Drosophila simulans (species) Drosophila mauritiana (species)	Drosophila sechellia (species) D	Svb/ovo	Drosophila sechellia (species)	Published - Accepted by Curator
tartan	Organ size (genitalia; clasper) Bristle number (genitalia; clasper)	Cis-regulatory, Unknown	Drosophila mauritiana (species) D	Interspecific	Linkage Mapping	Hagen JFD; Mendes CC; Blogg A ; et al. (2019) tartan underlies the evolution of Drosophila male genital morphology.	GP00002047	trn Q9VU51	Morphology Morphology	no coding changes	Drosophila simulans (species)	Drosophila mauritiana (species) D	tartan	Drosophila mauritiana (species)	Published - Accepted by Curator
Ultrabithorax (Ubx)	Trichome pattern (leg)	Cis-regulatory, Unknown	Drosophila simulans (species)	Interspecific	Candidate Gene	Stern DL (1998) A role of Ultrabithorax in morphological differences between Drosophila species.	GP00001161	Ubx P83949	Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Ultrabithorax (Ubx)	Drosophila simulans (species)	Published - Accepted by Curator
Zygotic hybrid rescue	F1 lethality (female-limited)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Ferree PM; Barbash DA (2009) Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality i[...]	GP00001228		Physiology	Heterochromatin incompatibilitity	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)	Zygotic hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator