ABCB7
Iron metabolism
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001379
ABCB7
O75027
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
ABCB7
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001920
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
ATP4A
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001928
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
ATP4A
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001921
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
ATP4B
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001929
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
ATP4B
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
BMP6
Tooth number
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Cleves PA; Ellis NA; Jimenez MT ; et al. (2014)
Evolved tooth gain in sticklebacks is associated with a cis-regulatory allele of Bmp6.
2 Additional References
GP00000154
Bmp6
P20722
Morphology
Candidate enhancer of 190bp recapitulating tooth and fin expression of BMP6
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
BMP6
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Ectodysplasin (EDA)
Dermal bone (loss of armor plates)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Interspecific
Linkage Mapping
Colosimo PF; Hosemann KE; Balabhadra S ; et al. (2005)
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
2 Additional References
GP00000254
Eda
O54693
Morphology
large haplotype- includes a T-> G regulatory change that affect expression based on differential responsiveness to Wnt signaling
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
Ectodysplasin (EDA)
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Fads2
Fatty acid metabolism (fatty acid desaturation)
Gene Amplification,
Insertion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Interspecific
Linkage Mapping
Ishikawa A; Kabeya N; Ikeya K ; et al. (2019)
A key metabolic gene for recurrent freshwater colonization and radiation in fishes.
GP00001959
fads2
Q9DEX7
Physiology
Fads2 locus is duplicated in G. aculeatus increasing DHA intake and the propensity to invade of freshwater environments. The ancestral copy is on linkage group 19 and the derived copy is on linkage group 12.
Gasterosteus nipponicus
(species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
Fads2
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
GDF6
Dermal bone size (armor plates)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Indjeian VB; Kingman GA; Jones FC ; et al. (2016)
Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.
GP00000388
GDF6
Q6KF10
Morphology
gain of a flank enhancer activity involving a complex repeat region; 1.2kb L2 LINE insertion; 18 small indels and 89 SNPs - the LINE insertion is required but not sufficient, to produce increased flank expression
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
GDF6
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
IGK
Pathogen resistance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001382
IGKV1-5
P01602
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
IGK
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
KCNH4 - uncertain
Freshwater adaptation
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Association Mapping
Jones FC; Grabherr MG; Chan YF ; et al. (2012)
The genomic basis of adaptive evolution in threespine sticklebacks.
GP00000510
KCNH4
Q9UQ05
Physiology
Large Inversion resulting in alternative transcripts
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
KCNH4 - uncertain
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Kit ligand
Coloration (gills; ventrum)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Linkage Mapping
Miller CT; Beleza S; Pollen AA ; et al. (2007)
cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...]
GP00000523
KITLG
P21583
Morphology
Not identified
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Kit ligand
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Mucin gene family
Salt tolerance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001378
MUC1
P15941
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Mucin gene family
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Na/K ATPase
Salt tolerance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001377
ATP1A1
P05023
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Na/K ATPase
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
opsin - (SWS2)
Color vision (blue- and red-shifts)
2 Mutations:
Coding
SNP
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Candidate Gene
Marques DA; Taylor JS; Jones FC ; et al. (2017)
Convergent evolution of SWS2 opsin facilitates adaptive radiation of threespine stickleback into dif[...]
GP00001679
opn1sw2
Q9W6A8
Physiology
2 mutations
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
opsin - (SWS2)
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001917
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A1
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001930
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A1
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001918
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A2
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001931
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A2
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001919
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A3
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001932
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A3
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000886
Pitx1
P70314
Morphology
488bp promoter region : deletion 1 ; 5 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000887
Pitx1
P70314
Morphology
488bp promoter region : deletion 2 ; 757bp deletion present in the pelvic-reduced BEPA population from Alaska
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000888
Pitx1
P70314
Morphology
488bp promoter region : deletion 3 ; 3.5 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000889
Pitx1
P70314
Morphology
488bp promoter region : deletion 4 ; 757 bp deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000890
Pitx1
P70314
Morphology
488bp promoter region : deletion 5 ; 2 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000891
Pitx1
P70314
Morphology
488bp promoter region : deletion 6 ; 973bp deletion present in the Hump Lake AK pelvic-reduced population (HUMP)
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000892
Pitx1
P70314
Morphology
488bp promoter region : deletion 7 ; 1868bp deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000893
Pitx1
P70314
Morphology
488bp promoter region : deletion 8 ; 8 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000894
Pitx1
P70314
Morphology
488bp promoter region : deletion 9 ; 8 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
PRKCD
Pathogen resistance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001381
PRKCD
Q05655
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
PRKCD
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
SOD3
Oxidative stress resistance
Blood pressure
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001380
SOD3
P08294
Physiology
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
SOD3
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
thyroid-stimulating hormone-beta-2
Metabolic rate
Thyroid Hormone (plasma concentration)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Candidate Gene
Kitano J; Lema SC; Luckenbach JA ; et al. (2010)
Adaptive divergence in the thyroid hormone signaling pathway in the stickleback radiation.
GP00001288
tshba
B3DJU0
Physiology
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
thyroid-stimulating hormone-beta-2
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator