Gephebase

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002617	ACC Q7JV23	Physiology	A1559V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002618	ACC Q7JV23	Physiology	A1847V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
Aminopeptidase N (APN)	Xenobiotic resistance (insecticide; Bt Cry2Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Experimental Evolution	Candidate Gene	Yang Y; Zhu YC; Ottea J ; et al. (2010) Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacil[...]	GP00002463	apn Q9VFX3	Physiology	deletion removing 22 amino acids. The mutant form failed to bind Cry1Ac unlike the full-length susceptible form. N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Aminopeptidase N (APN)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001488	BMH1 P29311	Physiology	C>G p.Y216* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001489	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001490	BMH1 P29311	Physiology	A>T p.K217* (2 times independently). Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001491	BMH1 P29311	Physiology	G>A p.D101N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001492	BMH1 P29311	Physiology	T>G p.L230* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001493	BMH1 P29311	Physiology	C>A p.N178K located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001494	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001495	BMH1 P29311	Physiology	G>T p.G174V homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001496	BMH1 P29311	Physiology	G>A p.G174D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001497	BMH1 P29311	Physiology	A>G p.N178S homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001498	BMH1 P29311	Physiology	G>A p.G55D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Fabrick JA; Mathew LG; Tabashnik BE (2011) Insertion of an intact CR1 retrotransposon in a cadherin gene linked with Bt resistance in the pink [...]	GP00002449	A0A1B0RHM4	Physiology	insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon designated CR1-1_Pg. Unlike most other CR1 elements CR1-1_Pg is intact and transcribed by a flanking promoter. It contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002450	A0A1B0RHM4	Physiology	24-bp deletion in putative exon 21 causing the loss of eight amino acid residues N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002451	A0A1B0RHM4	Physiology	126-bp deletion spanning a putative intron 15/exon 16 splice site that introduces a premature stop codon and causes loss of the final 929 amino acid residues. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
CG8492	Pathogen resistance (Drosophila C virus & flock house virus)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Experimental Evolution	Association Mapping	Martins NE; Faria VG; Nolte V ; et al. (2014) Host adaptation to viruses relies on few genes with different cross-resistance properties.	GP00001481	Dmel\CG8492 Q9VSA5	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CG8492	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cortex	Coloration (wing; seasonal)	Cis-regulatory, Unknown	Junonia coenia buckeye - (species) D	Experimental Evolution	Association Mapping	van der Burg KRL; Lewis JJ; Brack BJ ; et al. (2020) Genomic architecture of a genetically assimilated seasonal color pattern.	GP00002420	cort Q960N3	Morphology	No variation in coding region. Strong association with cis-regulatory SNP.	Junonia coenia buckeye - (species)	Junonia coenia buckeye - (species) D	cortex	Junonia coenia buckeye - (species)	Published - Accepted by Curator
COX18	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001708	COX18 P53239	Physiology	Leu59His (T>A at position 617107 according to Table 1) - CTY to CAY position 617107	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	COX18	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CYC8	Salt tolerance (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000195	CYC8 P14922	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	CYC8	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CYP9M6	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Experimental Evolution	Candidate Gene	Kasai S; Komagata O; Itokawa K ; et al. (2014) Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insens[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002448	CYP9M6 X5ICI6	Physiology	CYP9M6 has the capability to metabolize permethrin and is over expressed in the resistant strain partially due to gene amplification. The average copy number of the CYP9M9 gene is 4.6-fold more than the standard strain based on qPCR.	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	CYP9M6	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
ENA1-2-5 cluster	Salt tolerance (experimental evolution)	Gene Amplification, Complex Change	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000265	ENA1 P13587	Physiology	uncharacterized expansion	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	ENA1-2-5 cluster	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ENA1-2-5 cluster	Salt tolerance (experimental evolution)	Gene Amplification, Complex Change	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000266	ENA1 P13587	Physiology	uncharacterized expansion	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ENA1-2-5 cluster	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000286	ERG3 P32353	Physiology	Arg63Stop A187T in line 21 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001744	ERG3 P32353	Physiology	Ser76Stop C227A in line 22 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001745	ERG3 P32353	Physiology	Ser95Stop C284A in line 23 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001746	ERG3 P32353	Physiology	Trp205Stop G615A in line 24 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001747	ERG3 P32353	Physiology	Trp205Stop G615A in line 25 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001748	ERG3 P32353	Physiology	Trp205Stop G615A in line 26 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001749	ERG3 P32353	Physiology	Trp205Stop G615A in line 27 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001750	ERG3 P32353	Physiology	29-bp duplication in line 28 at nucleotide position 641 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001751	ERG3 P32353	Physiology	Trp219Stop G656A in line 29 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001752	ERG3 P32353	Physiology	Gly235Ser G703A in line 30 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001753	ERG3 P32353	Physiology	Tyr299Stop C897A in line 31 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001754	ERG3 P32353	Physiology	Gly300Arg G898C in line 32 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001755	ERG3 P32353	Physiology	Asp307Ala A920C in line 33 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001756	ERG3 P32353	Physiology	1-bp deletion in line 34 A980- N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001757	ERG3 P32353	Physiology	60-bp deletion at position 253 in line 35 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG5	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000287	ERG5 P54781	Physiology	60bp deletion N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG6	Xenobiotic resistance (drug)	Coding, Unknown	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000288	erg6 O14321	Physiology	7 unique mutations in ERG6 within a total 19 lines ; 4 of these mutations evolved multiple times	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	ERG6	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG7	Xenobiotic resistance (drug)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000289	ERG7 P38604	Physiology	Phe699Leu	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG7	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
herfst	Coloration (wing; seasonal)	Cis-regulatory, Unknown	Junonia coenia buckeye - (species) D	Experimental Evolution	Association Mapping	van der Burg KRL; Lewis JJ; Brack BJ ; et al. (2020) Genomic architecture of a genetically assimilated seasonal color pattern.	GP00002422	rk Q7KTA0	Morphology	No variation in coding region. Strong association with cis-regulatory SNP. CRISPR mutant clones for the herfst gene display light tan scales.	Junonia coenia buckeye - (species)	Junonia coenia buckeye - (species) D	herfst	Junonia coenia buckeye - (species)	Published - Accepted by Curator
HXT6/7	Low-glucose adaptation (experimental evolution)	Gene Amplification, Complex Change	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Brown CJ; Todd KM; Rosenzweig RF (1998) Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited [...] 4 Additional References Dunham MJ; Badrane H; Ferea T (2002) Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae. Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...] Gresham D; Desai MM; Tucker CM (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00000494	HXT6 P39003	Physiology	expansion by inequal recombination between HXT6 and HXT7 (99% nucleotide similarity) ; replicated in two independent studies and in multiple lines	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	HXT6/7	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
IRA1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001709	IRA1 P18963	Physiology	Arg1583Lys (G>A at position 521875 according to Table 1) - AGR to AAR position 521875	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	IRA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MAM3	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001303	PMA1 P05030	Physiology	C>G (Gly > Arg) @ position 250	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MAM3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MAM3	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001304	PMA1 P05030	Physiology	C>T (Val > Ile) @ position 1120	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MAM3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MAM3	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001305	PMA1 P05030	Physiology	C>T (Ser > Asn) @ position 806	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MAM3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MDS3	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000641	MDS3 P53094	Physiology	Phe - Val substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MDS3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MEP2	Salt tolerance (experimental evolution; low ammonium)	Other, Complex Change	Saccharomyces uvarum (species)	Experimental Evolution	Association Mapping	Dunn B; Paulish T; Stanbery A ; et al. (2013) Recurrent rearrangement during adaptive evolution in an interspecific yeast hybrid suggests a model [...]	GP00000651	MEP2 P41948	Physiology	Chimeric gene in diploid hybrids formed by recombination between the parental alleles	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces uvarum (species)	MEP2	Saccharomyces uvarum (species)	Published - Accepted by Curator
metallothionein CUP1	Metal tolerance (copper)	Gene Amplification, Complex Change	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001289	CUP1-1 P0CX80	Physiology	Gene duplication	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	metallothionein CUP1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MKT1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000662	MKT1 P40850	Physiology	D30G (reversion; functionally verified); evolved independently in 3 lines	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MKT1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MNN4	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001711	MNN4 P36044	Physiology	Lys924Glu (A>G at position 64698 according to Table 1) - AAR to GAR position 64698	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MNN4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00000679	CUP1-1 P0CX80	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00000680	CUP1-1 P0CX80	Physiology	Ty retrotranposition resulting in a coding frameshift N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MUK1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001713	MUK1 Q02866	Physiology	Ser441STP(C>A at position 422266 according to Table 1) - TCR to TAR position 422266	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MUK1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Experimental Evolution	Candidate Gene	Wang J; Wang X; Lansdell SJ ; et al. (2016) A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 s[...]	GP00002653	CHRNA6 Q15825	Physiology	a three amino acid (3-aa) deletion in the fourth transmembrane domain (TM4) of the nAChR α6 subunit N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	nAChR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
PHO5	Low-phosphate adaptation (experimental evolution)	Gene Amplification, Deletion	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00000863	PHO5 P00635	Physiology	Deletion. Out of 8 lines; 2 distinct lines evolved structural variation at PHO5. (Interestingly; one was a deletion and another one was a gene amplification)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	PHO5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PHO5	Low-phosphate adaptation (experimental evolution)	Gene Amplification, Insertion	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00000864	PHO5 P00635	Physiology	Gene duplication. Out of 8 lines; 2 distinct lines evolved structural variation at PHO5. (Interestingly; one was a deletion and another one was a gene amplification)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	PHO5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Plasma membrane ATPase 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001300	PMA1 P05030	Physiology	A>T (Phe > Ile) @ position 1831	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Plasma membrane ATPase 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Plasma membrane ATPase 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001301	PMA1 P05030	Physiology	T>G (Thr > Pro) @ position 2197	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Plasma membrane ATPase 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Plasma membrane ATPase 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001302	PMA1 P05030	Physiology	G>T (Ala > Asp) @ position 2204	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Plasma membrane ATPase 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 2 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...] Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000900	PMA1 P05030	Physiology	Leu363Trp	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 2 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...] Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000901	PMA1 P05030	Physiology	Ser234Cys	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000902	PMA1 P05030	Physiology	Val127Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000903	PMA1 P05030	Physiology	Val157Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000904	PMA1 P05030	Physiology	Gly294Val	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000905	PMA1 P05030	Physiology	Gly337Ser	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000906	PMA1 P05030	Physiology	Met530Ile	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000907	PMA1 P05030	Physiology	Pro535Thr	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000908	PMA1 P05030	Physiology	Iso564Thr	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000909	PMA1 P05030	Physiology	Ala732Val	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000910	PMA1 P05030	Physiology	Trp750Cys	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000952	RAS2 P01120	Physiology	Glu>Ala (A>C mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	RAS1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS2	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000954	RAS2 P01120	Physiology	Gly>Ser (C>T mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	RAS2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS2	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000955	RAS2 P01120	Physiology	Glu>Gln (C>G mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	RAS2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Experimental Evolution	Candidate Gene	Li A; Yang Y; Wu S ; et al. (2006) Investigation of resistance mechanisms to fipronil in diamondback moth (Lepidoptera: Plutellidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002562	Rdl P25123	Physiology	A302(GGC)--> S302(TCC)	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	resistance to dieldrin	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Sogatella furcifera white-backed planthopper - (species) D	Experimental Evolution	Candidate Gene	Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010 ) Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002563	Rdl P25123	Physiology	2 mutations	Sogatella furcifera white-backed planthopper - (species)	Sogatella furcifera white-backed planthopper - (species) D	resistance to dieldrin	Sogatella furcifera white-backed planthopper - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Oulema oryzae rice leaf beetle - (species) D	Experimental Evolution	Candidate Gene	Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010 ) Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002564	Rdl P25123	Physiology	A301S	Oulema oryzae rice leaf beetle - (species)	Oulema oryzae rice leaf beetle - (species) D	resistance to dieldrin	Oulema oryzae rice leaf beetle - (species)	Published - Accepted by Curator
RIM15	Low-glucose adaptation (experimental evolution)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00000989	RIM15 P43565	Physiology	1bp deletion resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	RIM15	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SLY41	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001712	SLY41 P22215	Physiology	Trp253Leu (G>T at position 893332 according to Table 1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	SLY41	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SUL1	Low-sulfate adaptation (experimental evolution)	Gene Amplification, Complex Change	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...] 1 Additional References Araya CL; Payen C; Dunham MJ (2010) Whole-genome sequencing of a laboratory-evolved yeast strain.	GP00001083	SUL1 P38359	Physiology	out of 16 lines; 15 distinct SUL1 amplification alleles evolved. Copy number ranged from 2 to 16 ; Amplicon size ranged from 2.5kb to 40kb	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	SUL1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
TAF5	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001710	TAF5 P38129	Physiology	Gly693Val (G>T at position 616441 according to Table 1) - GGN to GTN position 616441	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	TAF5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
TPD3	Cell size	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001499	TPD3 P31383	Physiology	C>T p.Q557* heterozygous nonsense mutation which may cause the larger cell size N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	TPD3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
trehalase	Coloration (wing; seasonal)	Cis-regulatory, Unknown	Junonia coenia buckeye - (species) D	Experimental Evolution	Association Mapping	van der Burg KRL; Lewis JJ; Brack BJ ; et al. (2020) Genomic architecture of a genetically assimilated seasonal color pattern.	GP00002421	Treh Q9W2M2	Morphology	Increased expression of the trehalase gene in the Red line. No variation in coding region. Strong association with cis-regulatory SNP.	Junonia coenia buckeye - (species)	Junonia coenia buckeye - (species) D	trehalase	Junonia coenia buckeye - (species)	Published - Accepted by Curator
TSA2	Xenobiotic resistance (hydrogen peroxide)	Gene Amplification, Complex Change	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Linkage Mapping	Linder RA; Greco JP; Seidl F ; et al. (2017) The Stress-Inducible Peroxidase TSA2 Underlies a Conditionally Beneficial Chromosomal Duplication in[...]	GP00001831	TSA2 Q04120	Physiology	Chromosome 4 whole duplication. Using a genetic mapping strategy that involves systematically deleting segments of a duplicated chromosome; the authors show that the chromosome IV’s duplication effect is largely due to the generation of a second copy of the stress-inducible cytoplasmic thioredoxin peroxidase TSA2.	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	TSA2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Ubiquitin conjugating enzyme E2H (Ubc-E2H)	Pathogen resistance (Drosophila C virus & cricket paralysis virus)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Experimental Evolution	Association Mapping	Martins NE; Faria VG; Nolte V ; et al. (2014) Host adaptation to viruses relies on few genes with different cross-resistance properties.	GP00001480	UbcE2H Q7JW03	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Ubiquitin conjugating enzyme E2H (Ubc-E2H)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001290	VTC1 P40046	Physiology	G>T (Asp > Tyr) @ position 289	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 1	Metal tolerance (copper)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001291	VTC1 P40046	Physiology	Pro > His+frameshift @ position 13 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 1	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001292	VTC1 P40046	Physiology	C>A (Ser > Stop) @ position 104 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001293	VTC4 P47075	Physiology	C>T (Trp > Stop) @ position 800 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001294	VTC4 P47075	Physiology	C>A (Glu > Stop) @ position 226 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001295	VTC4 P47075	Physiology	Phe > Ser+frameshift @ position 380 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001296	VTC4 P47075	Physiology	A>G (Tyr > His) @ position 1075	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001297	VTC4 P47075	Physiology	C>T (Trp > Stop) @ position 1320 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001298	VTC4 P47075	Physiology	T>A (Arg > Stop) @ position 757 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001299	VTC4 P47075	Physiology	C>A (Glu > Stop) @ position 1153 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator