Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002617	ACC Q7JV23	Physiology	A1559V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002618	ACC Q7JV23	Physiology	A1847V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
arcp-1	CO2 avoidance Aggregation behavior	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Beets I; Zhang G; Fenk LA ; et al. (2019) Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Alteri[...]	GP00002067	CELE_F34D10.6 C6KRH4	Behavior Behavior	8 bp deletion (mfP22) in the open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	arcp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001830	TUB2 P02557	Physiology	A185P - missense_variant_c.553G>C_3539974 – A185P N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001832	TUB2 P02557	Physiology	stop_gained_HIGH_c.1267C>T_3538394 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001833	TUB2 P02557	Physiology	Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001834	TUB2 P02557	Physiology	missense_variant_MODERATE_c.1210G>A_3538451 – D404N N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001835	TUB2 P02557	Physiology	Del_3539006_3539808 – 802bp deletion of coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001836	TUB2 P02557	Physiology	stop_gained_HIGH_c.1135A>T_3539335 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001837	TUB2 P02557	Physiology	stop_gained_HIGH_c.1112C>A_3539358 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001838	TUB2 P02557	Physiology	Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001839	TUB2 P02557	Physiology	Del_3539470_3539471 – 1bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001840	TUB2 P02557	Physiology	Del_3539507_3539514 – 7bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001841	TUB2 P02557	Physiology	Del_3539559_3539745 – 186 bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001842	TUB2 P02557	Physiology	Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001843	TUB2 P02557	Physiology	missense_variant_MODERATE_c.771G>A_3539699 – M257I N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001844	TUB2 P02557	Physiology	Del_3539746_3539908 – 162 bp deletion in exon3-4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001845	TUB2 P02557	Physiology	stop_gained_HIGH_c.549C>A_3539978 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001846	TUB2 P02557	Physiology	missense_variant_MODERATE_c.434C>T_3540145 – S145F N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001847	TUB2 P02557	Physiology	missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001848	TUB2 P02557	Physiology	Del_3540300_3540301 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Inversion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001849	TUB2 P02557	Physiology	Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Unknown N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001850	TUB2 P02557	Physiology	Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001851	TUB2 P02557	Physiology	Del_3540407_3540408 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001852	TUB2 P02557	Physiology	Del_3540970_3544000 – 3030bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001853	TUB2 P02557	Physiology	Del_3541317_3541856 – 539 bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001854	TUB2 P02557	Physiology	splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001855	TUB2 P02557	Physiology	stop_gained_HIGH_c.153T>G_3541441 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001856	TUB2 P02557	Physiology	Del_3541499_3541502 – 3bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001857	TUB2 P02557	Physiology	Ins_3541547_3541548 – 1 bp insertion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
drh-1	Pathogen resistance (viral immunity)	Coding, Deletion	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Ashe A; Bélicard T; Le Pen J ; et al. (2013) A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and an[...]	GP00001308	drh-1 G5EDI8	Physiology	159 base deletion in CDS resulting in truncated but potentially non-null protein	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	drh-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
exp-1	Aggregation behavior	Cis-regulatory, Unknown	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Bendesky A; Pitts J; Rockman MV ; et al. (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...]	GP00000300	exp-1 G5ECJ0	Behavior	unidentified; 6.2kb wide genetic interval 3' of the exp-1 gene	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	exp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
fog-2	Fertility (self-fertility; hermaphrodite spermatogenesis)	Gene Amplification, Complex Change	Caenorhabditis elegans (species)	Interspecific	Candidate Gene	Nayak S; Goree J; Schedl T (2005) fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis.	GP00000349	fog-2 Q2YS43	Physiology	Gene birth by duplication of an ancestral gene ; FOG-2 binds the translational regulator GLD-1 and promotes spermatogenesis ; see also tra-2 entry and associated references	Caenorhabditis briggsae (species)	Caenorhabditis elegans (species)	fog-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
glb-5	CO2 avoidance Aggregation behavior	Coding, Indel N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	McGrath PT; Rockman MV; Zimmer M ; et al. (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] 2 Additional References Bendesky A; Pitts J; Rockman MV (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...] Persson A; Gross E; Laurent P (2009) Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.	GP00000399	glb-5 A3RMS5	Behavior Behavior	765bp insertion/duplication resulting in a truncation of the last 179 amino acids of the protein and the inclusion of 40 different residues N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	glb-5	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLC-1	Xenobiotic resistance (antihelmintics)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Ghosh R; Andersen EC; Shapiro JA ; et al. (2012) Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.	GP00000400	glc-1 G5EBR3	Physiology	4aa deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	GLC-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000452	hecw-1 G5EEJ0	Behavior	Y322C	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000453	hecw-1 G5EEJ0	Behavior	Q325P	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
lanosterol c14 demethylase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intergeneric or Higher	Candidate Gene	Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001951	CYP51A1 Q16850	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Caenorhabditis elegans (species) D	lanosterol c14 demethylase	Caenorhabditis elegans (species)	Published - Accepted by Curator
lanosterol synthase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intergeneric or Higher	Candidate Gene	Kurzchalia TV; Ward S (2003) Why do worms need cholesterol? 1 Additional References Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001950	LSS P48449	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Caenorhabditis elegans (species) D	lanosterol synthase	Caenorhabditis elegans (species)	Published - Accepted by Curator
lin-48	Excretory duct position	4 Mutations: Cis-regulatory Unknown	Caenorhabditis elegans (species) D	Interspecific	Candidate Gene	Wang X; Chamberlin HM (2002) Multiple regulatory changes contribute to the evolution of the Caenorhabditis lin-48 ovo gene. 1 Additional References Wang X; Chamberlin HM (2004) Evolutionary innovation of the excretory system in Caenorhabditis elegans.	GP00000544	lin-48 G5EDU6	Morphology	4 mutations	Caenorhabditis briggsae (species) Caenorhabditis remanei (species) Caenorhabditis japonica (species)	Caenorhabditis elegans (species) D	lin-48	Caenorhabditis elegans (species)	Published - Accepted by Curator
mab-23	Male genitalia	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Lints R; Emmons SW (2002) Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the [...] 1 Additional References Hodgkin J; Doniach T (1997) Natural variation and copulatory plug formation in Caenorhabditis elegans.	GP00001323	mab-23 G5ECK3	Morphology	TGC>TTC - cysteine of the DM motif transformed into phenylalanine; so is likely to disrupt DNA-binding function N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	mab-23	Caenorhabditis elegans (species)	Published - Accepted by Curator
nath-10	Fertility (sperm number; egg laying rate)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Duveau F; Félix MA (2012) Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.	GP00000718	nath-10 O01757	Morphology	Met746Ile (according to Table S2 C>T but it should be G>A - Needs curation)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	nath-10	Caenorhabditis elegans (species)	Published - Accepted by Curator
npr-1	Aggregation behavior Foraging behavior CO2 avoidance Pathogen avoidance Fertility (competitive fitness)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	de Bono M; Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in[...] 5 Additional References Gloria-Soria A; Azevedo RB (2008) npr-1 Regulates foraging and dispersal strategies in Caenorhabditis elegans. Andersen EC; Bloom JS; Gerke JP (2014) A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth[...] McGrath PT; Rockman MV; Zimmer M (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] Reddy KC; Andersen EC; Kruglyak L (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Burga A; Ben-David E; Lemus Vergara T (2019) Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk.	GP00000739	npr-1 Q18534	Behavior Behavior Behavior Behavior Behavior; Physiology	Val215Phe (pleiotropic; see other entries)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	npr-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
nurf-1	Fertility (reproductive timing; egg laying rate) Lifespan Growth rate Diapause (dauer formation)	Coding, Deletion	Caenorhabditis elegans (species) D	Domesticated	Linkage Mapping	Large EE; Xu W; Zhao Y ; et al. (2016) Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticate[...]	GP00001318	nurf-1 Q6BER5	Physiology Physiology Physiology Physiology	60bp deletion	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	nurf-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001321	peel-1 G5EGC6	Physiology	1bp deletion creating a frameshift starting at amino acid position 43. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001322	peel-1 G5EGC6	Physiology	G>T - glycine to stop codon at position 57. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1/zeel-1	Hybrid incompatibility	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection. 1 Additional References Seidel HS; Ailion M; Li J (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]	GP00001320	peel-1 G5EGC6	Physiology	19kb deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	peel-1/zeel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
plep-1	Male-male copulatory behavior	Coding, SNP	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Noble LM; Chang AS; McNelis D ; et al. (2015) Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.	GP00000897	plep-1 A0A0K3AR66	Behavior	V278D	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	plep-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
plg-1	Copulatory plug	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Palopoli MF; Rockman MV; TinMaung A ; et al. (2008) Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.	GP00000898		Physiology	insertion of transposable element in an exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	plg-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
pot-2	Telomere length	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Cook DE; Zdraljevic S; Tanny RE ; et al. (2016) The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.	GP00001317	pot-2 O45595	Physiology	Phenylalanine-to-isoleucine (F68I) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	pot-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
ppw-1	Resistance to dsRNA	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Tijsterman M; Okihara KL; Thijssen K ; et al. (2002) PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]	GP00000921		Physiology	1bp deletion resulting in stop codon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	ppw-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
scd-2	Diapause	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Reiner DJ; Ailion M; Thomas JH ; et al. (2008) C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]	GP00001026	scd-2 O76411	Physiology	Gly985Arg	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	scd-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
sid-2	Immune response (RNAi efficiency)	Unknown, Unknown	Caenorhabditis elegans (species)	Interspecific	Candidate Gene	Winston WM; Sutherlin M; Wright AJ ; et al. (2007) Caenorhabditis elegans SID-2 is required for environmental RNA interference.	GP00001051	sid-2 G5EEV9	Physiology	unknown	Caenorhabditis (genus)	Caenorhabditis elegans (species)	sid-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
squalene synthase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intergeneric or Higher	Candidate Gene	Kurzchalia TV; Ward S (2003) Why do worms need cholesterol? 1 Additional References Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001947	FDFT1 P37268	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Caenorhabditis elegans (species) D	squalene synthase	Caenorhabditis elegans (species)	Published - Accepted by Curator
srg-36/37	Diapause (resistance to dauer-inducing pheromone)	Gene Loss, Deletion N	Caenorhabditis elegans (species)	Domesticated	Linkage Mapping	McGrath PT; Xu Y; Ailion M ; et al. (2011) Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.	GP00001075	srg-34 Q9XXQ5	Physiology	6795bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	srg-36/37	Caenorhabditis elegans (species)	Published - Accepted by Curator
srg-36/37	Diapause (resistance to dauer-inducing pheromone)	Gene Loss, Deletion N	Caenorhabditis elegans (species)	Domesticated	Linkage Mapping	McGrath PT; Xu Y; Ailion M ; et al. (2011) Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.	GP00001076	srg-34 Q9XXQ5	Physiology	4906bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	srg-36/37	Caenorhabditis elegans (species)	Published - Accepted by Curator
srx-43	Pheromone response (ascaroside)	Cis-regulatory, Unknown	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Greene JS; Brown M; Dobosiewicz M ; et al. (2016) Balancing selection shapes density-dependent foraging behaviour. 1 Additional References Greene JS; Dobosiewicz M; Butcher RA (2016) Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foragin[...]	GP00001319	srx-43 O45767	Physiology	unknown	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	srx-43	Caenorhabditis elegans (species)	Published - Accepted by Curator
srx-44	Pheromone response (ascaroside)	Cis-regulatory, Unknown	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Greene JS; Dobosiewicz M; Butcher RA ; et al. (2016) Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foragin[...] 1 Additional References Greene JS; Brown M; Dobosiewicz M (2016) Balancing selection shapes density-dependent foraging behaviour.	GP00001504	srx-43 O45767	Physiology	Phenotypic change mapped to a small region located between 34bp and 72 bp upstream of the srx-44 start codon. This DNA region contains 9 changes between N2 strain and MY14 strain.	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	srx-44	Caenorhabditis elegans (species)	Published - Accepted by Curator
sterol C5 desaturase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intergeneric or Higher	Candidate Gene	Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001954	ERG3 P32353	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Caenorhabditis elegans (species) D	sterol C5 desaturase	Caenorhabditis elegans (species)	Published - Accepted by Curator
str-217	Xenobiotic resistance (insecticide; DEET)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Candidate Gene	Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018) A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.	GP00001783	str-217 Q9XX85	Physiology	deletion that leads to a predicted frame shift and early stop codon - the predicted resulting protein has only one transmembrane domain instead of the 7 transmembrane domains - 138-bp deletion in exon 2 and 3 and intervening intron according to https://www.wormbase.org/species/c_elegans/variation/WBVar02076179#02-45-3 and email from Emily Dennis from 9 March 2019 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	str-217	Caenorhabditis elegans (species)	Published - Accepted by Curator
str-217	Xenobiotic resistance (insecticide; DEET)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Candidate Gene	Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018) A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.	GP00001784	str-217 Q9XX85	Physiology	on chromosome V position 17000292 G>A stop_gained 13C>T - Gln5* N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	str-217	Caenorhabditis elegans (species)	Published - Accepted by Curator
tra-2	Fertility (self-fertility; hermaphrodite spermatogenesis)	Cis-regulatory, Insertion	Caenorhabditis elegans (species)	Interspecific	Candidate Gene	Kuwabara PE (1996) Interspecies comparison reveals evolution of control regions in the nematode sex-determining gene tr[...] 2 Additional References Haag ES; Kimble J (2000) Regulatory elements required for development of caenorhabditis elegans hermaphrodites are conserved [...] Beadell AV; Liu Q; Johnson DM (2011) Independent recruitments of a translational regulator in the evolution of self-fertile nematodes.	GP00001132	tra-2 P34709	Physiology	Tandem duplication of GLD-1 binding sites in 3'UTR; see also fog-2 entry	Caenorhabditis briggsae (species)	Caenorhabditis elegans (species)	tra-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
tra-3 calpain-like protease	Body size (temperature-size interaction)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Kammenga JE; Doroszuk A; Riksen JA ; et al. (2007) A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide pol[...]	GP00001133	tra-3 Q22036	Physiology	F96L	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	tra-3 calpain-like protease	Caenorhabditis elegans (species)	Published - Accepted by Curator
Tyramine receptor 3	Exploration decision	Unknown, Unknown	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Bendesky A; Tsunozaki M; Rockman MV ; et al. (2011) Catecholamine receptor polymorphisms affect decision-making in C. elegans.	GP00001141	tyra-3 Q7JNP9	Behavior	Non-coding	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	Tyramine receptor 3	Caenorhabditis elegans (species)	Published - Accepted by Curator