Gephebase

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Your research retrieved 144 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...] 1 Additional References Grigoraki L; Cowlishaw R; Nolan T (2021) CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]	GP00000821	para P35500	Physiology	L1014F	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	F1014C	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005) Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...] 1 Additional References Franck P; Siegwart M; Olivares J (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D	para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000839	para P35500	Physiology	L925I in species D	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000840	para P35500	Physiology	M918L - ATG>CTG	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000841	para P35500	Physiology	T929N+L1014F	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000841	para P35500	Physiology	T929N+L1014F	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Candidate Gene	Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010) Determination of knockdown resistance allele frequencies in global human head louse populations usin[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Lee Si Hyeock; Gao Jian-Rong; Yoon Kyong Sup (2003 ) Sodium channel mutations associated with knockdown resistance in the human head louse, Pediculus cap[...]	GP00000846	para P35500	Physiology	M815I = M827I	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Vais H; Williamson MS; Devonshire AL ; et al. (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000846	para P35500	Physiology	T929I (ACC to ATC or ATA) = L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010) Determination of knockdown resistance allele frequencies in global human head louse populations usin[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000846	para P35500	Physiology	L920F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Sonoda S; Igaki C; Tsumuki H (2008) Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000848	para P35500	Physiology	M918I+L1014F	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Sonoda S; Igaki C; Tsumuki H (2008) Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000848	para P35500	Physiology	M918I+L1014F	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)	para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001689	para P35500	Physiology	L1014F; Haplotype H02	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001691	para P35500	Physiology	L1014S; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species)	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles vagus (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001692	para P35500	Physiology	L1014S	Anopheles vagus (species)	Anopheles vagus (species) D	para (kdr)	Anopheles vagus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001695	para P35500	Physiology	L1014S	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles paraliae (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001696	para P35500	Physiology	L1014S	Anopheles paraliae (species)	Anopheles paraliae (species)	para (kdr)	Anopheles paraliae (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001699	para P35500	Physiology	L1014F; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cimex lectularius bed bug - (species) D	Intraspecific	Candidate Gene	Yoon KS; Kwon DH; Strycharz JP ; et al. (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] 3 Additional References Yoon KS; Kwon DH; Strycharz JP (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Durand R; Cannet A; Berdjane Z (2012) Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France.	GP00001859	para P35500	Physiology	L925I	Cimex lectularius bed bug - (species)	Cimex lectularius bed bug - (species) D	para (kdr)	Cimex lectularius bed bug - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cimex lectularius bed bug - (species) D	Intraspecific	Candidate Gene	Yoon KS; Kwon DH; Strycharz JP ; et al. (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] 4 Additional References Yoon KS; Kwon DH; Strycharz JP (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] Seong KM; Lee DY; Yoon KS (2010) Establishment of quantitative sequencing and filter contact vial bioassay for monitoring pyrethroid [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Durand R; Cannet A; Berdjane Z (2012) Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France.	GP00001859	para P35500	Physiology	V419M - a Val to Met mutation at the corresponding position of the bed bug V419 has been identified in the tobacco budworm Heliothis virescens (Park et al. 1997) and functionally validated as a kdr-type mutation (Lee and Soderlund 2001)	Cimex lectularius bed bug - (species)	Cimex lectularius bed bug - (species) D	para (kdr)	Cimex lectularius bed bug - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	González-Cabrera J; Davies TG; Field LM ; et al. (2013) An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor. 1 Additional References Hubert J; Nesvorna M; Kamler M (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00001860	para P35500	Physiology	L925V	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001861	para P35500	Physiology	M918L - found in samples from China and Europe	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001862	para P35500	Physiology	L925I	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001862	para P35500	Physiology	T929I	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species)	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001863	para P35500	Physiology	M918L - ATG>TTG - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).	Hyalella azteca (species)	Hyalella azteca (species)	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001864	para P35500	Physiology	L925V	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 3 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...] Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] Fontaine S; Caddoux L; Brazier C (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...]	GP00001865	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 1 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...]	GP00001866	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 2 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...] Brengues C; Hawkes NJ; Chandre F (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...]	GP00002444	para P35500	Physiology	V1016G	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002445	para P35500	Physiology	F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Plernsub S; Saingamsook J; Yanola J ; et al. (2016) Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002446	para P35500	Physiology	V1016G	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Plernsub S; Saingamsook J; Yanola J ; et al. (2016) Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002446	para P35500	Physiology	S989P	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Plernsub S; Saingamsook J; Yanola J ; et al. (2016) Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002446	para P35500	Physiology	F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Kasai S; Ng LC; Lam-Phua SG ; et al. (2011) First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus. 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002447	para P35500	Physiology	F1534C	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002469	para P35500	Physiology	L1014S	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D	para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002470	para P35500	Physiology	L1014F	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D	para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002486	para P35500	Physiology	D1561V resulting from a GAC to GTC single base change and glutamic acid to glycine E1565G substitution resulting from a GAA to GGA single base change.	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002486	para P35500	Physiology	D1561V resulting from a GAC to GTC single base change and glutamic acid to glycine E1565G substitution resulting from a GAA to GGA single base change.	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002487	para P35500	Physiology	D1561V resulting from a GAC to GTC single base change and glutamic acid to glycine E1565G substitution resulting from a GAA to GGA single base change.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	para (kdr)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002487	para P35500	Physiology	D1561V resulting from a GAC to GTC single base change and glutamic acid to glycine E1565G substitution resulting from a GAA to GGA single base change.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	para (kdr)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Haddi K; Tomé HVV; Du Y ; et al. (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...] 1 Additional References Fan Y; O'Grady P; Yoshimizu M (2020) Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes ae[...]	GP00002488	para P35500	Physiology	The 410L+1534C allele appears to have arisen by accumulation of the 410L mutation in an individual already having the 1534C allele or by a crossover event. The F1534C occurred independently in several populations of Aedes aegypti.	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Haddi K; Tomé HVV; Du Y ; et al. (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...] 1 Additional References Fan Y; O'Grady P; Yoshimizu M (2020) Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes ae[...]	GP00002488	para P35500	Physiology	The 410L+1534C allele appears to have arisen by accumulation of the 410L mutation in an individual already having the 1534C allele or by a crossover event. The F1534C occurred independently in several populations of Aedes aegypti.	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Zhang L; Li T ; et al. (2012) Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following i[...]	GP00002489	para P35500	Physiology	3 nonsynonymous A(109)S L(982)F and W(1573)R) and 6 synonymous L(852) G(891) A(1241) D(1245) P(1249) and G(1733)) mutations were identified. The co-existence of all 9 mutations and their homozygousity were found to be important factors for high levels of resistance.	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Marshall Kate L; Moran Christopher; Chen Yizhou ; et al. (2012 ) Detection of kdr pyrethroid resistance in the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), u[...] 2 Additional References Wang ZJ; Liang CR; Shang ZY (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002490	para P35500	Physiology	L1014F	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Linkage Mapping	Nyoni BN; Gorman K; Mzilahowa T ; et al. (2011) Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation[...]	GP00002493	para P35500	Physiology	M918T - first report of the M918T mutation in the absence of L1014F in any arthropod species.	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D	para (kdr)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Liriomyza huidobrensis pea leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002494	para P35500	Physiology	M918T+L1014F	Liriomyza huidobrensis pea leafminer - (species)	Liriomyza huidobrensis pea leafminer - (species) D	para (kdr)	Liriomyza huidobrensis pea leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Liriomyza huidobrensis pea leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002494	para P35500	Physiology	M918T+L1014F	Liriomyza huidobrensis pea leafminer - (species)	Liriomyza huidobrensis pea leafminer - (species) D	para (kdr)	Liriomyza huidobrensis pea leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Liriomyza sativae vegetable leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002495	para P35500	Physiology	L1014F	Liriomyza sativae vegetable leafminer - (species)	Liriomyza sativae vegetable leafminer - (species) D	para (kdr)	Liriomyza sativae vegetable leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002496	para P35500	Physiology	M918T+L1014F	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002496	para P35500	Physiology	M918T+L1014F	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002497	para P35500	Physiology	T929I	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Carletto J; Martin T; Vanlerberghe-Masutti F ; et al. (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii.	GP00002498	para P35500	Physiology	M918L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002499	para P35500	Physiology	M918L in species B	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002500	para P35500	Physiology	M918L in species C	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Wu M; Gotoh H; Waters T ; et al. (2014) Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002501	para P35500	Physiology	M918L+V1010A	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Wu M; Gotoh H; Waters T ; et al. (2014) Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002501	para P35500	Physiology	M918T+L1014F	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Morgan JA; Corley SW; Jackson LA ; et al. (2009) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boop[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002502	para P35500	Physiology	L925I - Cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216 results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly Bemisia tabaci.	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao Wen Xue; Sonoda Shoji (2012 ) Resistance to cypermethrin in melon thrips, Thrips palmi (Thysanoptera: Thripidae), is conferred by [...]	GP00002503	para P35500	Physiology	T929I	Thrips palmi (species)	Thrips palmi (species) D	para (kdr)	Thrips palmi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002504	para P35500	Physiology	T929I	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitophilus zeamais maize weevil - (species) D	Intraspecific	Candidate Gene	Araújo RA; Williamson MS; Bass C ; et al. (2011) Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gat[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002505	para P35500	Physiology	T929I	Sitophilus zeamais maize weevil - (species)	Sitophilus zeamais maize weevil - (species) D	para (kdr)	Sitophilus zeamais maize weevil - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002506	para P35500	Physiology	T929V	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002507	para P35500	Physiology	T929C	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002508	para P35500	Physiology	T929I	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002509	para P35500	Physiology	L1014F	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Endersby NM; Viduka K; Baxter SW ; et al. (2011) Widespread pyrethroid resistance in Australian diamondback moth, Plutella xylostella (L.), is relate[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002510	para P35500	Physiology	F1020S	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002511	para P35500	Physiology	T929V	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002514	para P35500	Physiology	T929V	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002515	para P35500	Physiology	L1014F	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Jonsson NN; Cutullè C; Corley SW ; et al. (2010) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus microp[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00002516	para P35500	Physiology	G72V = G933V - G toT non-synonymous mutation at nucleotide position 214 that results in a glycine to valine substitution (G72V)	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002517	para P35500	Physiology	I951V = I936V	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Lepeophtheirus salmonis salmon louse - (species) D	Intraspecific	Candidate Gene	Fallang A; Denholm I; Horsberg TE ; et al. (2005) Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice Lepeophtheirus salm[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002518	para P35500	Physiology	Q945R in transmembrane segment IIS5	Lepeophtheirus salmonis salmon louse - (species)	Lepeophtheirus salmonis salmon louse - (species) D	para (kdr)	Lepeophtheirus salmonis salmon louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Brengues C; Hawkes NJ; Chandre F ; et al. (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002519	para P35500	Physiology	I104M = I1011M	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Saavedra-Rodriguez K; Urdaneta-Marquez L; Rajatileka S ; et al. (2007) A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin A[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002520	para P35500	Physiology	I1011V	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Enayati AA; Vatandoost H; Ladonni H ; et al. (2003) Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Ano[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Safi NHZ; Ahmadi AA; Nahzat S (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002521	para P35500	Physiology	L1014F - one point mutation difference involving a single A-T base change encoding a leucine to phenylalanine amino acid substitution in the pyrethroid-resistant strain.	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D	para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Safi NHZ; Ahmadi AA; Nahzat S ; et al. (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002522	para P35500	Physiology	L1014S	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D	para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles subpictus (species) D	Intraspecific	Candidate Gene	Karunaratne SHPP; Hawkes Nicola J; Perera MDB ; et al. (2007 ) Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populatio[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002523	para P35500	Physiology	L1014F - TTA>TTT	Anopheles subpictus (species)	Anopheles subpictus (species) D	para (kdr)	Anopheles subpictus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Liu H; Zhang L ; et al. (2005) Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002524	para P35500	Physiology	L1014F	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	D	Intraspecific	Candidate Gene	Rothwell JT; Morgan JA; James PJ ; et al. (2011) Mechanism of resistance to synthetic pyrethroids in buffalo flies in south-east Queensland. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002525	para P35500	Physiology	L1014F		D	para (kdr)		Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Brassicogethes aeneus (species)	Intraspecific	Candidate Gene	Nauen Ralf; Zimmer Christoph T; Andrews Melanie ; et al. (2012 ) Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F.[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002526	para P35500	Physiology	L1014F - found in individuals from Denmark and Sweden	Brassicogethes aeneus (species)	Brassicogethes aeneus (species)	para (kdr)	Brassicogethes aeneus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Foster SP; Paul VL; Slater R ; et al. (2014) A mutation (L1014F) in the voltage-gated sodium channel of the grain aphid, Sitobion avenae, is asso[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002527	para P35500	Physiology	L1014F	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D	para (kdr)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Cerchiari B; Giannini S ; et al. (2005) Use of the RFLP-PCR diagnostic test for characterizing MACE and kdr insecticide resistance in the pe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002528	para P35500	Physiology	F979S (housefly numbering) located inside the linker segment IIS5-6	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species)	Intraspecific	Candidate Gene	Stump AD; Atieli FK; Vulule JM ; et al. (2004) Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles ga[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002529	para P35500	Physiology	L1014S	Anopheles arabiensis (species)	Anopheles arabiensis (species)	para (kdr)	Anopheles arabiensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Dykes CL; Das MK ; et al. (2010) Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in [...]	GP00002530	para P35500	Physiology	L1014S	Anopheles culicifacies (species)	Anopheles culicifacies (species) D	para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Bali P; Hemingway J ; et al. (2009) PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato.	GP00002531	para P35500	Physiology	L1014F	Anopheles culicifacies (species)	Anopheles culicifacies (species) D	para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Lüleyap HU; Alptekin D; Kasap H ; et al. (2002) Detection of knockdown resistance mutations in Anopheles sacharovi (Diptera: Culicidae) and genetic [...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...]	GP00002532	para P35500	Physiology	L1014S	Anopheles sacharovi (species)	Anopheles sacharovi (species)	para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002533	para P35500	Physiology	L1014F	Anopheles sacharovi (species)	Anopheles sacharovi (species)	para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Pitzer JB; Kaufman PE (2011) Identification of a mutation associated with permethrin resistance in the para-type sodium channel o[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Olafson PU; Kaufman PE; Duvallet G (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002534	para P35500	Physiology	L1014H	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D	para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Kang S; Jung J; Lee S ; et al. (2012) The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles si[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002536	para P35500	Physiology	L1014C	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002537	para P35500	Physiology	L1014C in Nicaragua and Costa Rica individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D	para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002538	para P35500	Physiology	L1014F in Mexico individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D	para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Wang ZM; Li CX; Xing D ; et al. (2012) Detection and widespread distribution of sodium channel alleles characteristic of insecticide resist[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002539	para P35500	Physiology	L1014C	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Li CX; Wang ZM ; et al. (2012) First detection of multiple knockdown resistance (kdr)-like mutations in voltage-gated sodium channe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002540	para P35500	Physiology	L1014W	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Pridgeon Julia W; Appel Arthur G; Moar William J ; et al. (2002 ) Variability of resistance mechanisms in pyrethroid resistant German cockroaches (Dictyoptera: Blatte[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002541	para P35500	Physiology	F999S = F1020S - T to C at nt 2996 resulting in a phenylalanine999 to serine999 amino acid change	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Clark J Marshall; Lee Si Hyeock (2010 ) Cloning of a sodium channel gene and identification of mutations putatively associated with fenpropa[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002542	para P35500	Physiology	L1024V	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002543	para P35500	Physiology	A1549V = A1410V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002544	para P35500	Physiology	A1648V = A1494V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kawada H; Higa Y; Komagata O ; et al. (2009) Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroi[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002545	para P35500	Physiology	F1269C = F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus cinnabarinus carmine spider mite - (species) D	Intraspecific	Candidate Gene	Feng YN; Zhao S; Sun W ; et al. (2011) The sodium channel gene in Tetranychus cinnabarinus (Boisduval): identification and expression analy[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002546	para P35500	Physiology	F1538I	Tetranychus cinnabarinus carmine spider mite - (species)	Tetranychus cinnabarinus carmine spider mite - (species) D	para (kdr)	Tetranychus cinnabarinus carmine spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Tsagkarakou A; Van Leeuwen T; Khajehali J ; et al. (2009) Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-s[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002547	para P35500	Physiology	F1538I	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002548	para P35500	Physiology	M1524I	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Hubert J; Nesvorna M; Kamler M ; et al. (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00002549	para P35500	Physiology	F975L	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002550	para P35500	Physiology	F1528L+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]	GP00002551	para P35500	Physiology	F758L+L826P+I982V+M1055I = F1528L+L1596P+I1752V+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Kaufman PE; Duvallet G ; et al. (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002613	para P35500	Physiology	L1014F	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D	para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002614	para P35500	Physiology	M918I ATG>ATT	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002615	para P35500	Physiology	M918I ATG>ATA	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kushwah RBS; Kaur T; Dykes CL ; et al. (2020) A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegy[...]	GP00002625	para P35500	Physiology	F1534L - Phe (TTC) > Leu (CTC)	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002629	para P35500	Physiology	F1845Y	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002630	para P35500	Physiology	V1848I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002631	para P35500	Physiology	V1848I	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002632	para P35500	Physiology	F1845Y	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002644	para P35500	Physiology	super-kdr+D600N - super-kdr+D600N confers higher levels of resistance to seven pyrethroids relative to super-kdr.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002645	para P35500	Physiology	kdr+T929I - addition of T929I to the kdr mutation (L1014F) increased resistance to all pyrethroids (except etofenprox) and enhanced resistance by ~1000-fold to acrinathrin and flumethrin.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002646	para P35500	Physiology	F1534S	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002647	para P35500	Physiology	I1532T	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Fontaine S; Caddoux L; Brazier C ; et al. (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...] 1 Additional References Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00002649	para P35500	Physiology	L932F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator