Abcb4
Biliary Phospholipid Level (low)
Coding,
Unknown
N
Cavia porcellus
domestic guinea pig - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000008
Abcb4
P21440
Physiology
pseudogenization N
Mammalia
mammals - (class)
Cavia porcellus
domestic guinea pig - (species)
Abcb4
Cavia porcellus
domestic guinea pig - (species)
Published - Accepted by Curator
Abcb4
Biliary Phospholipid Level (low)
Coding,
Unknown
N
Equus caballus
horse - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000009
Abcb4
P21440
Physiology
pseudogenization N
Mammalia
mammals - (class)
Equus caballus
horse - (species)
Abcb4
Equus caballus
horse - (species)
Published - Accepted by Curator
AFGP multigene - antifreeze glycoproteins
Anti-freezing
Coding,
Unknown
Dissostichus mawsoni
Antarctic toothfish - (species)
Intergeneric or Higher
Candidate Gene
Chen L; DeVries AL; Cheng CH (1997)
Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
2 Additional References
GP00000052
afgp8
P24856
Physiology
multiple modifications of a pancreatic; secreted trypsinogen; notably via multiplications of small tri-peptidic repeats
Teleostei
teleost fishes - (infraclass)
Dissostichus mawsoni
Antarctic toothfish - (species)
AFGP multigene - antifreeze glycoproteins
Dissostichus mawsoni
Antarctic toothfish - (species)
Published - Accepted by Curator
AHR
Xenobiotic resistance (dioxins; polycyclic aromatic hydrocarbons; TCDD)
2 Mutations:
Coding
SNP
Sterna hirundo hirundo
(subspecies) D
Intergeneric or Higher
Candidate Gene
Karchner SI; Franks DG; Kennedy SW ; et al. (2006)
The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon recep[...]
1 Additional References
GP00001811
Ahr
P30561
Physiology
2 mutations
Gallus gallus
chicken - (species)
Sterna hirundo hirundo
(subspecies) D
AHR
Sterna hirundo hirundo
(subspecies)
Published - Accepted by Curator
ameloblastin (AMBN)
Tooth absence (no enamel production)
Gene Loss,
Deletion
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001934
AMBN
Q9NP70
Physiology
synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
ameloblastin (AMBN)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
ameloblastin (AMBN)
Tooth absence (no enamel production)
Coding,
Unknown
N
Mysticeti
baleen whales - (suborder) D
Intergeneric or Higher
Candidate Gene
Deméré TA; McGowen MR; Berta A ; et al. (2008)
Morphological and molecular evidence for a stepwise evolutionary transition from teeth to baleen in [...]
1 Additional References
GP00001938
AMBN
Q9NP70
Physiology
multiple frameshift mutations N
Cetacea
whales - (order)
Mysticeti
baleen whales - (suborder) D
ameloblastin (AMBN)
Mysticeti
baleen whales - (suborder)
Published - Accepted by Curator
amelogenin (AMEL)
Tooth absence (no enamel production)
3 Mutations:
Coding
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001933
Amelx
P63277
Physiology
3 mutations
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
amelogenin (AMEL)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
amelogenin (AMEL)
Tooth absence (no enamel production)
Coding,
Unknown
N
Mysticeti
baleen whales - (suborder) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Cheng J ; et al. (2011)
Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]
GP00001937
Amelx
P63277
Physiology
J. Gatesy 2010 unpublished data cited in the main reference N
Cetacea
whales - (order)
Mysticeti
baleen whales - (suborder) D
amelogenin (AMEL)
Mysticeti
baleen whales - (suborder)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Cebus capucinus
white-faced sapajou - (species) D
Intergeneric or Higher
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001870
Amy1
P00687
Physiology
3-4 copies of the amylase gene; which coincides with increased levels of amylase activity in saliva
Aotus trivirgatus
douroucouli - (species)
Callithrix jacchus
white-tufted-ear marmoset - (species)
Cebus capucinus
white-faced sapajou - (species) D
amylase
Cebus capucinus
white-faced sapajou - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Papio anubis
olive baboon - (species) D
Intergeneric or Higher
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001871
Amy1
P00687
Physiology
3-4 copies of the amylase gene; which coincides with increased levels of amylase activity in saliva
Cercocebus atys
sooty mangabey - (species)
Macaca mulatta
Rhesus monkey - (species)
Papio anubis
olive baboon - (species) D
amylase
Papio anubis
olive baboon - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001908
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
ATP4A
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001920
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
ATP4A
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001922
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
ATP4A
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001928
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
ATP4A
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
3 Mutations:
Coding
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001909
ATP4B
P51164
Physiology
3 mutations
Monodelphis domestica
gray short-tailed opossum - (species)
Homo sapiens
human - (species)
Ornithorhynchus anatinus
platypus - (species) D
ATP4B
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Callorhinchus milii
elephant shark - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001916
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence N
Scyliorhinus canicula
smaller spotted catshark - (species)
Callorhinchus milii
elephant shark - (species) D
ATP4B
Callorhinchus milii
elephant shark - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001921
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
ATP4B
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001923
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
ATP4B
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001929
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
ATP4B
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2
Carotenoid content (sexual dichromatism, male-specific)
Unknown,
Unknown
Serinus canaria
common canary - (species)
Intergeneric or Higher
Linkage Mapping
Gazda MA; Araújo PM; Lopes RJ ; et al. (2020)
A genetic mechanism for sexual dichromatism in birds.
GP00002139
BCO2
Q9BYV7
Morphology
Gene expression study suggests a cis-regulatory difference ; and coding mutations are unlikely to be causal
Spinus cucullatus
red siskin - (species)
Serinus canaria
common canary - (species)
BCO2 = beta-carotene oxygenase 2
Serinus canaria
common canary - (species)
Published - Accepted by Curator
BRANCHED1a (BRC1a)
Plant architecture
Inflorescence architecture
Coding,
SNP
Solanum
(genus) D
Intergeneric or Higher
Candidate Gene
Nicolas M; Rodríguez-Buey ML; Franco-Zorrilla JM ; et al. (2015)
A Recently Evolved Alternative Splice Site in the BRANCHED1a Gene Controls Potato Plant Architecture[...]
GP00000156
BRC1A
F6KB94
Morphology
Morphology
Evolution of an alternative splice site (G>A) that unlocks a short isoform
Capsicum annuum
(species)
Solanum
(genus) D
BRANCHED1a (BRC1a)
Solanum
(genus)
Published - Accepted by Curator
cathepsin E
Digestion (absence of stomach)
2 Mutations:
Coding
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001910
CTSE
P14091
Physiology
2 mutations
Monodelphis domestica
gray short-tailed opossum - (species)
Homo sapiens
human - (species)
Ornithorhynchus anatinus
platypus - (species) D
cathepsin E
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
2 Mutations:
Coding
SNP
Erinaceus concolor
southern white-breasted hedgehog - (species) D
Erinaceus europaeus
western European hedgehog - (species) D
Intergeneric or Higher
Candidate Gene
Drabeck DH; Dean AM; Jansa SA (2015)
Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]
GP00000183
CHRNA1
P02708
Physiology
2 mutations
Carnivora
carnivores - (order)
Erinaceus concolor
southern white-breasted hedgehog - (species) D
Erinaceus europaeus
western European hedgehog - (species) D
CHRNA1
Erinaceus concolor
southern white-breasted hedgehog - (species)
Erinaceus europaeus
western European hedgehog - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
2 Mutations:
Coding
SNP
Mellivora capensis
ratel - (species) D
Intergeneric or Higher
Candidate Gene
Drabeck DH; Dean AM; Jansa SA (2015)
Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]
GP00000184
CHRNA1
P02708
Physiology
2 mutations
Carnivora
carnivores - (order)
Mellivora capensis
ratel - (species) D
CHRNA1
Mellivora capensis
ratel - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
4 Mutations:
Coding
SNP
Herpestes ichneumon
Egyptian mongoose - (species) D
Intergeneric or Higher
Candidate Gene
Barchan D; Kachalsky S; Neumann D ; et al. (1992)
How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.
2 Additional References
GP00001686
CHRNA1
P02708
Physiology
4 mutations
Carnivora
carnivores - (order)
Herpestes ichneumon
Egyptian mongoose - (species) D
CHRNA1
Herpestes ichneumon
Egyptian mongoose - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
Coding,
SNP
Naja haje
(species) D
Intergeneric or Higher
Candidate Gene
Takacs Z; Wilhelmsen KC; Sorota S (2004)
Cobra ( Naja spp. ) nicotinic acetylcholine receptor exhibits resistance to Erabu sea snake ( Latica[...]
GP00001720
CHRNA1
P02708
Physiology
Phe189Asn - The inhibitory effect on the pharmacological action of the toxin is primarily attributed to the presence of glycosylation at position N189.
Carnivora
carnivores - (order)
Naja haje
(species) D
CHRNA1
Naja haje
(species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
2 Mutations:
Coding
SNP
Sus scrofa
pig - (species) D
Intergeneric or Higher
Candidate Gene
Drabeck DH; Dean AM; Jansa SA (2015)
Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]
GP00001721
CHRNA1
P02708
Physiology
2 mutations
Carnivora
carnivores - (order)
Sus scrofa
pig - (species) D
CHRNA1
Sus scrofa
pig - (species)
Published - Accepted by Curator
CYP6B4
Xenobiotic resistance
Host plant specialization
Coding,
SNP
Papilio glaucus
eastern tiger swallowtail - (species)
Intergeneric or Higher
Candidate Gene
Mao W; Schuler MA; Berenbaum MR (2007)
Cytochrome P450s in Papilio multicaudatus and the transition from oligophagy to polyphagy in the Pap[...]
GP00000206
CYP6B4
Q27902
Physiology
Physiology
Lys484Ser and probably other a.a. substitutions
Nymphalidae
brushfoots - (family)
Papilio glaucus
eastern tiger swallowtail - (species)
CYP6B4
Papilio glaucus
eastern tiger swallowtail - (species)
Published - Accepted by Curator
D14 (KAI2 paralog)
Seed dormancy (strigolactone responsiveness)
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species) D
Intergeneric or Higher
Candidate Gene
Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015)
PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]
GP00000213
D14
Q10QA5
Physiology
Ligand-binding pocket tuning
Spermatophyta
(no rank)
Arabidopsis thaliana
thale cress - (species) D
D14 (KAI2 paralog)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
dentin sialophosphoprotein (DSPP)
Tooth absence (no enamel production)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001936
DSPP
Q9NZW4
Physiology
synteny of the corresponding region - only the N-terminal region of DSPP is present in the genome - 1-bp deletion in exon one leading to a reading frame shift were this sequence to be translated N
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
dentin sialophosphoprotein (DSPP)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth absence (no enamel production)
Gene Loss,
Deletion
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001935
ENAM
Q9NRM1
Physiology
synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
enamelin (ENAM)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth absence (no enamel production)
Coding,
Deletion
N
Eubalaena glacialis
North Atlantic right whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
Eschrichtius robustus
grey whale - (species) D
Caperea marginata
pygmy right whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
1 Additional References
GP00001939
ENAM
Q9NRM1
Physiology
1-bp deletion. Various frameshift mutations were found in the distinct species. N
Cetacea
whales - (order)
Eubalaena glacialis
North Atlantic right whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
Eschrichtius robustus
grey whale - (species) D
Caperea marginata
pygmy right whale - (species) D
enamelin (ENAM)
Eubalaena glacialis
North Atlantic right whale - (species)
Megaptera novaeangliae
humpback whale - (species)
Eschrichtius robustus
grey whale - (species)
Caperea marginata
pygmy right whale - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
2 Mutations:
Coding
Deletion
N
Kogia sima
dwarf sperm whale - (species) D
Kogia breviceps
pygmy sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
1 Additional References
GP00001942
ENAM
Q9NRM1
Physiology
2 mutations
Physeter catodon
sperm whale - (species)
Kogia sima
dwarf sperm whale - (species) D
Kogia breviceps
pygmy sperm whale - (species) D
enamelin (ENAM)
Kogia sima
dwarf sperm whale - (species)
Kogia breviceps
pygmy sperm whale - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
3 Mutations:
Coding
N
Orycteropus afer
aardvark - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
GP00001943
ENAM
Q9NRM1
Physiology
3 mutations
Elephantulus rufescens
East African long-eared elephant shrew - (species)
Orycteropus afer
aardvark - (species) D
enamelin (ENAM)
Orycteropus afer
aardvark - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
Coding,
Unknown
N
Manis pentadactyla
Chinese pangolin - (species) D
Manis tricuspis
Tree pangolin - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
GP00001944
ENAM
Q9NRM1
Physiology
multiple deletions and insertions less than 9bp causing frameshift N
Canis lupus familiaris
dog - (subspecies)
Manis pentadactyla
Chinese pangolin - (species) D
Manis tricuspis
Tree pangolin - (species) D
enamelin (ENAM)
Manis pentadactyla
Chinese pangolin - (species)
Manis tricuspis
Tree pangolin - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
Coding,
Unknown
N
Bradypus tridactylus
Pale-throated sloth - (species) D
Tamandua tetradactyla
southern tamandua - (species) D
Dasypus novemcinctus
nine-banded armadillo - (species) D
Euphractus sexcinctus
(species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
GP00001945
ENAM
Q9NRM1
Physiology
multiple frameshift insertions and deletions N
Canis lupus familiaris
dog - (subspecies)
Bradypus tridactylus
Pale-throated sloth - (species) D
Tamandua tetradactyla
southern tamandua - (species) D
Dasypus novemcinctus
nine-banded armadillo - (species) D
Euphractus sexcinctus
(species) D
enamelin (ENAM)
Bradypus tridactylus
Pale-throated sloth - (species)
Tamandua tetradactyla
southern tamandua - (species)
Dasypus novemcinctus
nine-banded armadillo - (species)
Euphractus sexcinctus
(species)
Published - Accepted by Curator
enamelysin (MMP20)
Tooth absence (no enamel production)
Coding,
Insertion
N
Balaenoptera physalus
Fin whale - (species) D
Balaena mysticetus
bowhead whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Cheng J ; et al. (2011)
Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]
GP00001940
MMP20
O60882
Physiology
insertion of a CHR-2 SINE retroposon in exon 2 of MMP20 which would result in premature truncation of the MMP20 protein owing to stop codons in all possible reading frames of the CHR-2 SINE. The length of the MMP20 SINE ranges from 302 bp (B. musculus) to 318 bp (B. physalus). This mutation is found in eight investigated species of baleen whales. Other inactivating mutations (nonsense and frameshift mutations) are found in various species N
Physeter catodon
sperm whale - (species)
Balaenoptera physalus
Fin whale - (species) D
Balaena mysticetus
bowhead whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
enamelysin (MMP20)
Balaenoptera physalus
Fin whale - (species)
Balaena mysticetus
bowhead whale - (species)
Megaptera novaeangliae
humpback whale - (species)
Published - Accepted by Curator
enamelysin (MMP20)
Tooth composition (no enamel production)
Coding,
SNP
N
Kogia breviceps
pygmy sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Cheng J ; et al. (2011)
Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]
GP00001941
MMP20
O60882
Physiology
opal stop codon (TGA) in the propeptide-coding region of MMP20 exon 2 in a single individual of the pygmy sperm whale Kogia breviceps N
Kogia sima
dwarf sperm whale - (species)
Kogia breviceps
pygmy sperm whale - (species) D
enamelysin (MMP20)
Kogia breviceps
pygmy sperm whale - (species)
Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)
Increase in antiviral ribonuclease activity
Coding,
SNP
Catarrhini
(parvorder)
Intergeneric or Higher
Candidate Gene
Zhang J; Rosenberg HF (2002)
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.
GP00000272
RNASE2
P10153
Physiology
Arg64Ser
Primates
(order)
Catarrhini
(parvorder)
eosinophil-derived neurotoxin (EDN)
Catarrhini
(parvorder)
Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)
Increase in antiviral ribonuclease activity
Coding,
SNP
Catarrhini
(parvorder)
Intergeneric or Higher
Candidate Gene
Zhang J; Rosenberg HF (2002)
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.
GP00000273
RNASE2
P10153
Physiology
Thr132Arg
Primates
(order)
Catarrhini
(parvorder)
eosinophil-derived neurotoxin (EDN)
Catarrhini
(parvorder)
Published - Accepted by Curator
Fezf2
Cerebral cortex layered organization
Cis-regulatory,
Complex Change
Mammalia
mammals - (class) D
Intergeneric or Higher
Candidate Gene
Shim S; Kwan KY; Li M ; et al. (2012)
Cis-regulatory control of corticospinal system development and evolution.
GP00000307
Fezf2
Q9ESP5
Morphology
Acquisition of SOX binding sites in enhancer E4
Amniota
amniotes - (no rank)
Mammalia
mammals - (class) D
Fezf2
Mammalia
mammals - (class)
Published - Accepted by Curator
FMO1
Xenobiotic resistance
Host plant specialization
Gene Amplification,
Complex Change
Tyria jacobaeae
cinnabar moth - (species)
Intergeneric or Higher
Candidate Gene
Sehlmeyer S; Wang L; Langel D ; et al. (2010)
Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arct[...]
GP00000348
Fmo-1
Q9W1E9
Physiology
Physiology
Gene duplication
Lepidoptera
butterflies and moths - (order)
Tyria jacobaeae
cinnabar moth - (species)
FMO1
Tyria jacobaeae
cinnabar moth - (species)
Published - Accepted by Curator
GAL1
Carbohydrate metabolism (galactose)
Cis-regulatory,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species)
Intergeneric or Higher
Candidate Gene
Hittinger CT; Carroll SB (2007)
Gene duplication and the adaptive evolution of a classic genetic switch.
GP00000385
GAL1
P09608
Physiology
Helical phasing of GAL4 elements in promoter region following duplication
Kluyveromyces lactis
(species)
Saccharomyces cerevisiae
baker's yeast - (species)
GAL1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
gastrin
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001914
GAST
P01350
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
gastrin
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
GDF6
Limb morphology (hindlimb;skeleton)
Cis-regulatory,
Deletion
Homininae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Indjeian VB; Kingman GA; Jones FC ; et al. (2016)
Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.
GP00000389
GDF6
Q6KF10
Morphology
Loss of a limb specific enhancer, the deletion is 5.6 kb
Homo sapiens
human - (species)
Homininae
(subfamily) D
GDF6
Homininae
(subfamily)
Published - Accepted by Curator
GLUD2 retrogene
Gene expression change (novel expression domain in testicles and brain)
Gene Amplification,
Complex Change
Hominidae
great apes - (family) D
Intergeneric or Higher
Candidate Gene
Burki F; Kaessmann H (2004)
Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.
1 Additional References
GP00000405
GLUD2
P49448
Physiology
Retroduplication; + E7K enhancing mitochondrial targeting
Mammalia
mammals - (class)
Hominidae
great apes - (family) D
GLUD2 retrogene
Hominidae
great apes - (family)
Published - Accepted by Curator
Green-sensitive opsin (RH2)
Color vision (blue shift)
Coding,
SNP
Thunnus orientalis
Pacific bluefin tuna - (species) D
Intergeneric or Higher
Candidate Gene
Nakamura Y; Mori K; Saitoh K ; et al. (2013)
Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna[...]
GP00001469
opn1mw1
Q9W6A5
Physiology
p.E122Q (G>C) in four of five genes
Percomorphaceae
(no rank)
Thunnus orientalis
Pacific bluefin tuna - (species) D
Green-sensitive opsin (RH2)
Thunnus orientalis
Pacific bluefin tuna - (species)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Cavia porcellus
domestic guinea pig - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000420
Gulo
P58710
Physiology
pseudogenization involving invalidating mutations at most exons N
Mammalia
mammals - (class)
Cavia porcellus
domestic guinea pig - (species)
Gulo
Cavia porcellus
domestic guinea pig - (species)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Myotis lucifugus
little brown bat - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000421
Gulo
P58710
Physiology
pseudogenization N
Mammalia
mammals - (class)
Myotis lucifugus
little brown bat - (species)
Gulo
Myotis lucifugus
little brown bat - (species)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Primates
(order)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000422
Gulo
P58710
Physiology
pseudogenization N
Mammalia
mammals - (class)
Primates
(order)
Gulo
Primates
(order)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Pteropus vampyrus
large flying fox - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000423
Gulo
P58710
Physiology
pseudogenization N
Mammalia
mammals - (class)
Pteropus vampyrus
large flying fox - (species)
Gulo
Pteropus vampyrus
large flying fox - (species)
Published - Accepted by Curator
hemoglobin; HBA and HBB
Hypoxia response
Coding,
SNP
Crocodylus niloticus
Nile crocodile - (species)
Intergeneric or Higher
Candidate Gene
Komiyama NH; Miyazaki G; Tame J ; et al. (1995)
Transplanting a unique allosteric effect from crocodile into human haemoglobin.
GP00000455
HBA1
P69905
Physiology
No more than 12 amino acid substitutions required for providing crocodile-like properties in engineered human Hb - effect of single amino acid changes not tested
Homo sapiens
human - (species)
Crocodylus niloticus
Nile crocodile - (species)
hemoglobin; HBA and HBB
Crocodylus niloticus
Nile crocodile - (species)
Published - Accepted by Curator
hemoglobin; HBB/HBD fusion gene
Temperature tolerance (cold)
3 Mutations:
Coding
SNP
Mammuthus primigenius
woolly mammoth - (species)
Intergeneric or Higher
Candidate Gene
Campbell KL; Roberts JE; Watson LN ; et al. (2010)
Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance[...]
GP00000477
HBB
P68871
Physiology
3 mutations
Elephantidae
elephants - (family)
Mammuthus primigenius
woolly mammoth - (species)
hemoglobin; HBB/HBD fusion gene
Mammuthus primigenius
woolly mammoth - (species)
Published - Accepted by Curator
Hox gene cluster
Body plan (number of segments)
Gene Loss,
Deletion
N
Hypsibius dujardini
(species) D
Paramacrobiotus richtersi
(species) D
Milnesium tardigradum
(species) D
Intergeneric or Higher
Candidate Gene
Smith FW; Boothby TC; Giovannini I ; et al. (2016)
The Compact Body Plan of Tardigrades Evolved by the Loss of a Large Body Region.
GP00001946
Antp
P02833
Morphology
The three genes Antp Ubx AbdA are missing in the genome sequences of the three tardigrades. This loss is ancient so difficult to evaluate whether the three genes were lost due to a single mutational event or due to successive mutations. The Hox cluster is disorganized in the H. dujardini genome. N
Drosophila melanogaster
fruit fly - (species)
Hypsibius dujardini
(species) D
Paramacrobiotus richtersi
(species) D
Milnesium tardigradum
(species) D
Hox gene cluster
Hypsibius dujardini
(species)
Paramacrobiotus richtersi
(species)
Milnesium tardigradum
(species)
Published - Accepted by Curator
KAI2 paralogs
Seed dormancy (strigolactone responsiveness)
Coding,
Unknown
Orobancheae
(tribe) D
Intergeneric or Higher
Candidate Gene
Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015)
PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]
GP00000509
D14
Q10QA5
Physiology
Ligand-binding pocket tuning in duplicated gene
Orobanchaceae
(family)
Orobancheae
(tribe) D
KAI2 paralogs
Orobancheae
(tribe)
Published - Accepted by Curator
lanosterol c14 demethylase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001951
CYP51A1
Q16850
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
lanosterol c14 demethylase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
lanosterol c14 demethylase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001952
CYP51A1
Q16850
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
lanosterol c14 demethylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
lanosterol synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001949
LSS
P48449
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
lanosterol synthase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
lanosterol synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001950
LSS
P48449
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
lanosterol synthase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
LOC105383139
Courtship behavior
Other,
Insertion
Lepidoptera
butterflies and moths - (order) D
Intergeneric or Higher
Association Mapping
Li Y; Liu Z; Liu C ; et al. (2022)
HGT is widespread in insects and contributes to male courtship in lepidopterans.
GP00002412
Behavior
Horizontal Gene Transfer from Listeria bacteria to Lepidoptera of an entire gene coding region. The gene contains an alcohol dehydrogenase domain and a zinc-binding dehydrogenase domain.
Trichoptera
caddisflies - (order)
Lepidoptera
butterflies and moths - (order) D
LOC105383139
Lepidoptera
butterflies and moths - (order)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
Coding,
SNP
Pyrophorus plagiophthalamus
(species)
Intergeneric or Higher
Candidate Gene
Wood KV; Lam YA; Seliger HH ; et al. (1989)
Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors.
GP00000552
P08659
Physiology
several nucleotide substitutions leading to several amino acid changes -exact amino acid changes unknown
Photinus pyralis
common eastern firefly - (species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
lysozyme
Digestion (anaerobic enzymatic activity)
5 Mutations:
Coding
SNP
Opisthocomus hoazin
(species) D
Intergeneric or Higher
Candidate Gene
Kornegay JR; Schilling JW; Wilson AC (1994)
Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.
GP00000556
LYZ1
P04421
Physiology
5 mutations
Aves
birds - (class)
Opisthocomus hoazin
(species) D
lysozyme
Opisthocomus hoazin
(species)
Published - Accepted by Curator
lysozyme
Digestion (anaerobic enzymatic activity)
5 Mutations:
Coding
SNP
Bos taurus
cattle - (species)
Intergeneric or Higher
Candidate Gene
Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2)
Adaptive evolution in the stomach lysozymes of foregut fermenters.
1 Additional References
GP00000557
LYZ1
P04421
Physiology
5 mutations
Mammalia
mammals - (class)
Bos taurus
cattle - (species)
lysozyme
Bos taurus
cattle - (species)
Published - Accepted by Curator
lysozyme
Digestion (anaerobic enzymatic activity)
5 Mutations:
Coding
SNP
Colobinae
(subfamily)
Intergeneric or Higher
Candidate Gene
Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2)
Adaptive evolution in the stomach lysozymes of foregut fermenters.
3 Additional References
GP00000558
LYZ1
P04421
Physiology
5 mutations
Primates
(order)
Colobinae
(subfamily)
lysozyme
Colobinae
(subfamily)
Published - Accepted by Curator
Myogenic factor 5 (Myf5)
Rib morphology (skeleton)
Cis-regulatory,
SNP
Pantherophis guttatus guttatus
(subspecies) D
Malayopython reticulatus
reticulated python - (species) D
Boa constrictor
boa - (species) D
Intergeneric or Higher
Candidate Gene
Guerreiro I; Nunes A; Woltering JM ; et al. (2013)
Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine.
GP00001716
Myf5
P24699
Morphology
one nucleotide change at a Hox binding site (CTAATTG to CCAATTG) - mouse transgenics and protein-DNA binding assay
Squamata
squamates - (order)
Pantherophis guttatus guttatus
(subspecies) D
Malayopython reticulatus
reticulated python - (species) D
Boa constrictor
boa - (species) D
Myogenic factor 5 (Myf5)
Pantherophis guttatus guttatus
(subspecies)
Malayopython reticulatus
reticulated python - (species)
Boa constrictor
boa - (species)
Published - Accepted by Curator
Myogenic factor 5 (Myf5)
Rib morphology (skeleton)
Cis-regulatory,
SNP
Trichechus manatus
West Indian manatee - (species) D
Procavia capensis
Cape rock hyrax - (species) D
Loxodonta africana
African savanna elephant - (species) D
Intergeneric or Higher
Candidate Gene
Guerreiro I; Nunes A; Woltering JM ; et al. (2013)
Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine.
GP00001717
Myf5
P24699
Morphology
one nucleotide change at a Hox binding site (CTAATTG to CCAATTG) - mouse transgenics and protein-DNA binding assay
Eutheria
placentals - (no rank)
Trichechus manatus
West Indian manatee - (species) D
Procavia capensis
Cape rock hyrax - (species) D
Loxodonta africana
African savanna elephant - (species) D
Myogenic factor 5 (Myf5)
Trichechus manatus
West Indian manatee - (species)
Procavia capensis
Cape rock hyrax - (species)
Loxodonta africana
African savanna elephant - (species)
Published - Accepted by Curator
myosin heavy chain 16 (MYH16)
Masticatory muscles
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intergeneric or Higher
Candidate Gene
Stedman HH; Kozyak BW; Nelson A ; et al. (2004)
Myosin gene mutation correlates with anatomical changes in the human lineage.
GP00000683
MYH16
Q9H6N6
Morphology
2bp deletion at codon 660 N
Pan troglodytes
chimpanzee - (species)
Homo sapiens
human - (species) D
myosin heavy chain 16 (MYH16)
Homo sapiens
human - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Natricinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000700
Atp1a1
Q8VDN2
Physiology
2 mutations
Colubridae
colubrid snakes - (family)
Natricinae
(subfamily) D
Na/K-ATPase alpha-subunit
Natricinae
(subfamily)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Atelopus spumarius
Pebas stubfoot toad - (species) D
Rhinella marina
marine toad - (species) D
Rhinella granulosa
granular toad - (species) D
Intergeneric or Higher
Candidate Gene
Moore DJ; Halliday DC; Rowell DM ; et al. (2009)
Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...]
1 Additional References
GP00000702
Atp1a1
Q8VDN2
Physiology
2 mutations
Hyloidea
(superfamily)
Atelopus spumarius
Pebas stubfoot toad - (species) D
Rhinella marina
marine toad - (species) D
Rhinella granulosa
granular toad - (species) D
Na/K-ATPase alpha-subunit
Atelopus spumarius
Pebas stubfoot toad - (species)
Rhinella marina
marine toad - (species)
Rhinella granulosa
granular toad - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Naja melanoleuca
forest cobra - (species) D
Naja naja
Indian cobra - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000703
Atp1a1
Q8VDN2
Physiology
2 mutations
Ophiophagus hannah
king cobra - (species)
Pseudechis australis
mulga snake - (species)
Hemiaspis signata
(species)
Naja melanoleuca
forest cobra - (species) D
Naja naja
Indian cobra - (species) D
Na/K-ATPase alpha-subunit
Naja melanoleuca
forest cobra - (species)
Naja naja
Indian cobra - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Erinaceus europaeus
western European hedgehog - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000708
Atp1a1
Q8VDN2
Physiology
2 mutations
Condylura cristata
star-nosed mole - (species)
Erinaceus europaeus
western European hedgehog - (species) D
Na/K-ATPase alpha-subunit
Erinaceus europaeus
western European hedgehog - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
4 Mutations:
Coding
SNP
Oncopeltus fasciatus
milkweed bug - (species) D
Lygaeus kalmii
(species) D
Intergeneric or Higher
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
2 Additional References
GP00000709
Atp1a1
Q8VDN2
Physiology
4 mutations
Insecta
true insects - (class)
Oncopeltus fasciatus
milkweed bug - (species) D
Lygaeus kalmii
(species) D
Na/K-ATPase alpha-subunit
Oncopeltus fasciatus
milkweed bug - (species)
Lygaeus kalmii
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Labidomera clivicollis
(species) D
Intergeneric or Higher
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
1 Additional References
GP00000710
Atp1a1
Q8VDN2
Physiology
2 mutations
Insecta
true insects - (class)
Labidomera clivicollis
(species) D
Na/K-ATPase alpha-subunit
Labidomera clivicollis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Murinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000714
Atp1a1
Q8VDN2
Physiology
2 mutations
Rodentia
rodent - (order)
Murinae
(subfamily) D
Na/K-ATPase alpha-subunit
Murinae
(subfamily)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Bitis arietans
puff adder - (species) D
Bitis nasicornis
rhinoceros viper - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000716
Atp1a1
Q8VDN2
Physiology
2 mutations
Vipera berus
adder - (species)
Bitis arietans
puff adder - (species) D
Bitis nasicornis
rhinoceros viper - (species) D
Na/K-ATPase alpha-subunit
Bitis arietans
puff adder - (species)
Bitis nasicornis
rhinoceros viper - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
Unknown
Hydra vulgaris
(species) D
Intergeneric or Higher
Candidate Gene
Canfield VA; Xu KY; D'Aquila T ; et al. (1992)
Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme e[...]
GP00001738
Atp1a1
Q8VDN2
Physiology
Eumetazoa
(no rank)
Hydra vulgaris
(species) D
Na/K-ATPase alpha-subunit
Hydra vulgaris
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Rattus norvegicus
Norway rat - (species) D
Mus musculus
house mouse - (species) D
Mesocricetus auratus
golden hamster - (species) D
Peromyscus maniculatus
North American deer mouse - (species) D
Nannospalax galili
Upper Galilee mountains blind mole rat - (species) D
Intergeneric or Higher
Candidate Gene
Shull GE; Greeb J; Lingrel JB (1986)
Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.
1 Additional References
GP00001739
Atp1a1
Q8VDN2
Physiology
2 mutations
Jaculus jaculus
lesser Egyptian jerboa - (species)
Spermophilus
old world ground squirrels - (genus)
Rattus norvegicus
Norway rat - (species) D
Mus musculus
house mouse - (species) D
Mesocricetus auratus
golden hamster - (species) D
Peromyscus maniculatus
North American deer mouse - (species) D
Nannospalax galili
Upper Galilee mountains blind mole rat - (species) D
Na/K-ATPase alpha-subunit
Rattus norvegicus
Norway rat - (species)
Mus musculus
house mouse - (species)
Mesocricetus auratus
golden hamster - (species)
Peromyscus maniculatus
North American deer mouse - (species)
Nannospalax galili
Upper Galilee mountains blind mole rat - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Oncopeltus fasciatus
milkweed bug - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
1 Additional References
GP00001740
Atp1a1
Q8VDN2
Physiology
Q111T
Lygaeus kalmii
(species)
Oncopeltus fasciatus
milkweed bug - (species) D
Na/K-ATPase alpha-subunit
Oncopeltus fasciatus
milkweed bug - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00001742
Atp1a1
Q8VDN2
Physiology
Q111L
Holometabola
(cohort)
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Na/K-ATPase alpha-subunit
Saucrobotys futilalis
dogbane pyralid moth - (species)
Published - Accepted by Curator
Nav1 sodium channel
Xenobiotic resistance (pyrethroid; tau-fluvalinate)
3 Mutations:
Coding
SNP
Bombus impatiens
common eastern bumble bee - (species) D
Apis mellifera
honey bee - (species) D
Dufourea novaeangliae
(species) D
Eufriesea mexicana
(species) D
Habropoda laboriosa
(species) D
Melipona quadrifasciata
(species) D
Megachile rotundata
alfalfa leafcutting bee - (species) D
Athalia rosae
coleseed sawfly - (species) D
Intergeneric or Higher
Candidate Gene
Wu S; Nomura Y; Du Y ; et al. (2017)
Molecular basis of selective resistance of the bumblebee BiNa1 sodium channel to tau-fluvalinate.
GP00002648
SCN8A
Q9UQD0
Physiology
3 mutations
Polistes dominula
European paper wasp - (species)
Orussus abietinus
(species)
Diachasma alloeum
(species)
Bombus impatiens
common eastern bumble bee - (species) D
Apis mellifera
honey bee - (species) D
Dufourea novaeangliae
(species) D
Eufriesea mexicana
(species) D
Habropoda laboriosa
(species) D
Melipona quadrifasciata
(species) D
Megachile rotundata
alfalfa leafcutting bee - (species) D
Athalia rosae
coleseed sawfly - (species) D
Nav1 sodium channel
Bombus impatiens
common eastern bumble bee - (species)
Apis mellifera
honey bee - (species)
Dufourea novaeangliae
(species)
Eufriesea mexicana
(species)
Habropoda laboriosa
(species)
Melipona quadrifasciata
(species)
Megachile rotundata
alfalfa leafcutting bee - (species)
Athalia rosae
coleseed sawfly - (species)
Published - Accepted by Curator
neurogenin 3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001915
NEUROG3
Q9Y4Z2
Physiology
Absence of the gene in the genome sequence - Neurogenin-3 is a transcription factor whose activity is required for the specification of gastric epithelial cell identity - Deficiency of this factor results in considerably smaller stomachs and absence of gastrin-secreting G cells: somatostatin-secreting D cells and glucagon-secreting A cells N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
neurogenin 3
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision
Coding,
Deletion
N
Mysticeti
baleen whales - (suborder) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000756
OPN1SW
P03999
Physiology
4bp frameshift deletion in exon 1 of SWS1 that results in a premature stop codon N
Cetacea
whales - (order)
Mysticeti
baleen whales - (suborder) D
opsin - (SWS1)
Mysticeti
baleen whales - (suborder)
Published - Accepted by Curator
opsin - (SWS1)
Color vision
Coding,
SNP
Odontoceti
tooth whales - (suborder)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000757
OPN1SW
P03999
Physiology
E113G; disrupts opsin-chromophore binding
Cetacea
whales - (order)
Odontoceti
tooth whales - (suborder)
opsin - (SWS1)
Odontoceti
tooth whales - (suborder)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (loss of violet-range sensitivity)
Coding,
Deletion
N
Sciurus carolinensis
gray squirrel - (species) D
Intergeneric or Higher
Candidate Gene
Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006)
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.
GP00000758
OPN1SW
P03999
Physiology
6bp deletion (residues 77-78) + 1bp frameshift deletion N
Sciurus carolinensis
gray squirrel - (species)
Sciurus carolinensis
gray squirrel - (species) D
opsin - (SWS1)
Sciurus carolinensis
gray squirrel - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (loss of violet-range sensitivity)
Coding,
Deletion
Sciurus carolinensis
gray squirrel - (species) D
Intergeneric or Higher
Candidate Gene
Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006)
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.
GP00000759
OPN1SW
P03999
Physiology
9bp deletion (residues 93-95)
Sciurus carolinensis
gray squirrel - (species)
Sciurus carolinensis
gray squirrel - (species) D
opsin - (SWS1)
Sciurus carolinensis
gray squirrel - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Melopsittacus undulatus
budgerigar - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Radlwimmer FB; Blow NS (2000)
Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change.
1 Additional References
GP00000760
OPN1SW
P03999
Physiology
2 mutations
Aves
birds - (class)
Melopsittacus undulatus
budgerigar - (species) D
opsin - (SWS1)
Melopsittacus undulatus
budgerigar - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Rhea americana
greater rhea - (species) D
Intergeneric or Higher
Candidate Gene
Odeen A; Hastad O (2003)
Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...]
2 Additional References
GP00000761
OPN1SW
P03999
Physiology
2 mutations
Aves
birds - (class)
Rhea americana
greater rhea - (species) D
opsin - (SWS1)
Rhea americana
greater rhea - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Larus
(genus) D
Intergeneric or Higher
Candidate Gene
Odeen A; Hastad O (2003)
Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...]
1 Additional References
GP00000762
OPN1SW
P03999
Physiology
2 mutations
Aves
birds - (class)
Larus
(genus) D
opsin - (SWS1)
Larus
(genus)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
Coding,
SNP
Trogon curucui
(species) D
Intergeneric or Higher
Candidate Gene
Odeen A; Hastad O (2003)
Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...]
1 Additional References
GP00000763
OPN1SW
P03999
Physiology
S86F
Aves
birds - (class)
Trogon curucui
(species) D
opsin - (SWS1)
Trogon curucui
(species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
Coding,
SNP
Taeniopygia guttata
zebra finch - (species)
Intergeneric or Higher
Candidate Gene
Yokoyama S; Radlwimmer FB; Blow NS (2000)
Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change.
1 Additional References
GP00000764
OPN1SW
P03999
Physiology
S90C
Passeriformes
(order)
Taeniopygia guttata
zebra finch - (species)
opsin - (SWS1)
Taeniopygia guttata
zebra finch - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
3 Mutations:
Coding
SNP
Xenopus laevis
African clawed frog - (species) D
Intergeneric or Higher
Candidate Gene
Takahashi Y; Yokoyama S (2005)
Genetic basis of spectral tuning in the violet-sensitive visual pigment of African clawed frog, Xeno[...]
GP00000765
OPN1SW
P03999
Physiology
3 mutations
Amniota
amniotes - (no rank)
Xenopus laevis
African clawed frog - (species) D
opsin - (SWS1)
Xenopus laevis
African clawed frog - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
SNP
Macropodidae
(family)
Intergeneric or Higher
Candidate Gene
Deeb SS; Wakefield MJ; Tada T ; et al. (2003)
The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence[...]
1 Additional References
GP00000766
OPN1SW
P03999
Physiology
F86Y
Metatheria
marsupials - (no rank)
Macropodidae
(family)
opsin - (SWS1)
Macropodidae
(family)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
SNP
Cavia porcellus
domestic guinea pig - (species)
Intergeneric or Higher
Candidate Gene
Parry JW; Poopalasundaram S; Bowmaker JK ; et al. (2004)
A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visu[...]
GP00000767
OPN1SW
P03999
Physiology
F86V
Rodentia
rodent - (order)
Cavia porcellus
domestic guinea pig - (species)
opsin - (SWS1)
Cavia porcellus
domestic guinea pig - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
SNP
Sciurus carolinensis
gray squirrel - (species)
Intergeneric or Higher
Candidate Gene
Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006)
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.
GP00000768
OPN1SW
P03999
Physiology
F86Y
Rodentia
rodent - (order)
Sciurus carolinensis
gray squirrel - (species)
opsin - (SWS1)
Sciurus carolinensis
gray squirrel - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
Coding,
SNP
Aves
birds - (class) D
Intergeneric or Higher
Candidate Gene
Carvalho LS; Cowing JA; Wilkie SE ; et al. (2007)
The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.
1 Additional References
GP00001694
OPN1SW
P03999
Physiology
V116L
Vertebrata
vertebrates - (no rank)
Aves
birds - (class) D
opsin - (SWS1)
Aves
birds - (class)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
Deletion
Lepidopus fitchi
(species) D
Intergeneric or Higher
Candidate Gene
Tada T; Altun A; Yokoyama S (2009)
Evolutionary replacement of UV vision by violet vision in fish.
GP00001704
OPN1SW
P03999
Physiology
deletion of Phe86 (3-bp deletion)
Actinopterygii
ray-finned fishes - (superclass)
Lepidopus fitchi
(species) D
opsin - (SWS1)
Lepidopus fitchi
(species)
Published - Accepted by Curator
opsin - (SWS2)
Color vision
3 Mutations:
Coding
SNP
Cottus gobio
bullhead - (species) D
Intergeneric or Higher
Candidate Gene
Cowing JA; Poopalasundaram S; Wilkie SE ; et al. (2002)
Spectral tuning and evolution of short wave-sensitive cone pigments in cottoid fish from Lake Baikal[...]
GP00001771
opn1sw2
Q9W6A8
Physiology
3 mutations
Cottidae
sculpins - (family)
Cottus gobio
bullhead - (species) D
opsin - (SWS2)
Cottus gobio
bullhead - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWRh)
Color vision (blue shift)
2 Mutations:
Coding
SNP
Limenitis archippus
viceroy - (species)
Intergeneric or Higher
Candidate Gene
Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007)
Adaptive evolution of color vision as seen through the eyes of butterflies.
GP00000769
LWRh
E2DZP1
Physiology
2 mutations
Limenitis arthemis
white admiral - (species)
Limenitis archippus
viceroy - (species)
opsin - rhodopsin (LWRh)
Limenitis archippus
viceroy - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWRh)
Color vision (blue shift)
2 Mutations:
Coding
SNP
Junonia
buckeyes - (genus)
Intergeneric or Higher
Candidate Gene
Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007)
Adaptive evolution of color vision as seen through the eyes of butterflies.
GP00000770
LWRh
E2DZP1
Physiology
2 mutations
Nymphalidae
brushfoots - (family)
Junonia
buckeyes - (genus)
opsin - rhodopsin (LWRh)
Junonia
buckeyes - (genus)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Deletion
N
Balaenopteridae
rorquals - (family) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000771
OPN1LW
P04000
Physiology
22bp deletion including transciption start N
Cetacea
whales - (order)
Balaenopteridae
rorquals - (family) D
opsin - rhodopsin (LWS)
Balaenopteridae
rorquals - (family)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Deletion
N
Kogia breviceps
pygmy sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000772
OPN1LW
P04000
Physiology
44bp frameshift deletion 9 + possibly GT to CT splice site mutation N
Cetacea
whales - (order)
Kogia breviceps
pygmy sperm whale - (species) D
opsin - rhodopsin (LWS)
Kogia breviceps
pygmy sperm whale - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Deletion
N
Physeter catodon
sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000773
OPN1LW
P04000
Physiology
1bp + 28bp frameshift deletions N
Cetacea
whales - (order)
Physeter catodon
sperm whale - (species) D
opsin - rhodopsin (LWS)
Physeter catodon
sperm whale - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Insertion
N
Mesoplodon bidens
Sowerby's beaked whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000774
OPN1LW
P04000
Physiology
4bp frameshift insertion in exon 2 of LWS N
Cetacea
whales - (order)
Mesoplodon bidens
Sowerby's beaked whale - (species) D
opsin - rhodopsin (LWS)
Mesoplodon bidens
Sowerby's beaked whale - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
SNP
Balaenidae
right whales - (family)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000775
OPN1LW
P04000
Physiology
AG to GG splice site mutation
Cetacea
whales - (order)
Balaenidae
right whales - (family)
opsin - rhodopsin (LWS)
Balaenidae
right whales - (family)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision (blue-shift)
Coding,
SNP
Tursiops truncatus
bottlenose dolphin - (species) D
Intergeneric or Higher
Candidate Gene
Fasick JI; Robsinson PR (1998)
Mechanism of spectral tuning in the dolphin visual pigments.
GP00001703
OPN1LW
P04000
Physiology
A292S
Mammalia
mammals - (class)
Tursiops truncatus
bottlenose dolphin - (species) D
opsin - rhodopsin (LWS)
Tursiops truncatus
bottlenose dolphin - (species)
Published - Accepted by Curator
opsin - rhodopsin (MWS=duplicate of LWS)
Color vision (green-shift)
7 Mutations:
Coding
SNP
Catarrhini
(parvorder)
Intergeneric or Higher
Candidate Gene
Asenjo AB; Rim J; Oprian DD (1994)
Molecular determinants of human red/green color discrimination.
1 Additional References
GP00000778
OPN1MW
P04001
Physiology
7 mutations
Primates
(order)
Catarrhini
(parvorder)
opsin - rhodopsin (MWS=duplicate of LWS)
Catarrhini
(parvorder)
Published - Accepted by Curator
opsin - rhodopsin (UVRh2)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Heliconius pachinus
(species)
Heliconius erato
crimson-patched longwing - (species)
Heliconius hortense
(species)
Heliconius sapho
(species)
Heliconius charithonia
zebra longwing - (species)
Heliconius melpomene
postman butterfly - (species)
Heliconius elevatus
(species)
Heliconius cydno
(species)
Intergeneric or Higher
Candidate Gene
Briscoe AD; Bybee SM; Bernard GD ; et al. (2010)
Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution[...]
1 Additional References
GP00000779
UVRh2
E2DZL8
Physiology
2 mutations
Nymphalidae
brushfoots - (family)
Heliconius pachinus
(species)
Heliconius erato
crimson-patched longwing - (species)
Heliconius hortense
(species)
Heliconius sapho
(species)
Heliconius charithonia
zebra longwing - (species)
Heliconius melpomene
postman butterfly - (species)
Heliconius elevatus
(species)
Heliconius cydno
(species)
opsin - rhodopsin (UVRh2)
Heliconius pachinus
(species)
Heliconius erato
crimson-patched longwing - (species)
Heliconius hortense
(species)
Heliconius sapho
(species)
Heliconius charithonia
zebra longwing - (species)
Heliconius melpomene
postman butterfly - (species)
Heliconius elevatus
(species)
Heliconius cydno
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
2 Mutations:
Coding
SNP
undetermined Cottoidei 'Lake Baikal'
(species)
Intergeneric or Higher
Candidate Gene
Hunt DM; Fitzgibbon J; Slobodyanyuk SJ ; et al. (1996)
Spectral tuning and molecular evolution of rod visual pigments in the species flock of cottoid fish [...]
GP00000780
RHO
P08100
Physiology
2 mutations
undetermined Cottoidei 'Lake Baikal'
(species)
undetermined Cottoidei 'Lake Baikal'
(species)
opsin - rhodopsin1 (RH1)
undetermined Cottoidei 'Lake Baikal'
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
Coding,
SNP
Megaderma lyra
Indian false vampire - (species) D
Intergeneric or Higher
Candidate Gene
Sugawara T; Imai H; Nikaido M ; et al. (2010)
Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.
GP00000781
RHO
P08100
Physiology
D83N
Chiroptera
bats - (order)
Megaderma lyra
Indian false vampire - (species) D
opsin - rhodopsin1 (RH1)
Megaderma lyra
Indian false vampire - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
2 Mutations:
Coding
SNP
Sebastolobus altivelis
(species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T; Yamato T (2007 Mar-Apr)
Modulation of the absorption maximum of rhodopsin by amino acids in the C-terminus.
1 Additional References
GP00000782
RHO
P08100
Physiology
2 mutations
Teleostei
teleost fishes - (infraclass)
Sebastolobus altivelis
(species) D
opsin - rhodopsin1 (RH1)
Sebastolobus altivelis
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
Coding,
SNP
Flaveria trinervia
(species)
Intergeneric or Higher
Candidate Gene
Sugawara T; Imai H; Nikaido M ; et al. (2010)
Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.
GP00000783
RHO
P08100
Physiology
D83N
Vespertilionidae
common bats - (family)
Flaveria trinervia
(species)
opsin - rhodopsin1 (RH1)
Flaveria trinervia
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
Squamata
squamates - (order) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Zhang H; Radlwimmer FB ; et al. (1999)
Adaptive evolution of color vision of the Comoran coelacanth (Latimeria chalumnae).
1 Additional References
GP00000784
RHO
P08100
Physiology
D83N
Amniota
amniotes - (no rank)
Squamata
squamates - (order) D
opsin - rhodopsin1 (RH1)
Squamata
squamates - (order)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
2 Mutations:
Coding
SNP
Orcinus orca
killer whale - (species) D
Intergeneric or Higher
Candidate Gene
Dungan SZ; Kosyakov A; Chang BS (2016)
Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functi[...]
1 Additional References
GP00000785
RHO
P08100
Physiology
2 mutations
Bos taurus
cattle - (species)
Orcinus orca
killer whale - (species) D
opsin - rhodopsin1 (RH1)
Orcinus orca
killer whale - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
African cichlids
(no rank)
Intergeneric or Higher
Candidate Gene
Sugawara T; Terai Y; Imai H ; et al. (2005)
Parallelism of amino acid changes at the RH1 affecting spectral sensitivity among deep-water cichlid[...]
1 Additional References
GP00000786
RHO
P08100
Physiology
A292S and reversals; many independent cases
African cichlids
(no rank)
African cichlids
(no rank)
opsin - rhodopsin1 (RH1)
African cichlids
(no rank)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
3 Mutations:
Coding
SNP
Tursiops truncatus
bottlenose dolphin - (species)
Intergeneric or Higher
Candidate Gene
Fasick JI; Robsinson PR (1998)
Mechanism of spectral tuning in the dolphin visual pigments.
2 Additional References
GP00000787
RHO
P08100
Physiology
3 mutations
Mammalia
mammals - (class)
Tursiops truncatus
bottlenose dolphin - (species)
opsin - rhodopsin1 (RH1)
Tursiops truncatus
bottlenose dolphin - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
Elephantidae
elephants - (family)
Intergeneric or Higher
Candidate Gene
Yokoyama S; Takenaka N; Agnew DW ; et al. (2005)
Elephants and human color-blind deuteranopes have identical sets of visual pigments.
1 Additional References
GP00000788
RHO
P08100
Physiology
D83N
Mammalia
mammals - (class)
Elephantidae
elephants - (family)
opsin - rhodopsin1 (RH1)
Elephantidae
elephants - (family)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
Physeteridae
sperm whales - (family)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000789
RHO
P08100
Physiology
K195T
Cetacea
whales - (order)
Physeteridae
sperm whales - (family)
opsin - rhodopsin1 (RH1)
Physeteridae
sperm whales - (family)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
2 Mutations:
Coding
SNP
Latimeria menadoensis
Menado coelacanth - (species) D
Latimeria chalumnae
coelacanth - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T (2000)
Adaptive evolution of the African and Indonesian coelacanths to deep-sea environments.
GP00000790
RHO
P08100
Physiology
2 mutations
Teleostei
teleost fishes - (infraclass)
Latimeria menadoensis
Menado coelacanth - (species) D
Latimeria chalumnae
coelacanth - (species) D
opsin - rhodopsin1 (RH1)
Latimeria menadoensis
Menado coelacanth - (species)
Latimeria chalumnae
coelacanth - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
2 Mutations:
Coding
SNP
Cetacea
whales - (order)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000791
RHO
P08100
Physiology
2 mutations
Mammalia
mammals - (class)
Cetacea
whales - (order)
opsin - rhodopsin1 (RH1)
Cetacea
whales - (order)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (red-shift)
Coding,
SNP
Aristostomias scintillans
shiny loosejaw - (species)
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T; Zhang H ; et al. (2008)
Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]
1 Additional References
GP00000792
RHO
P08100
Physiology
D83N; M183F; M253L; F261Y; T289G; S292I; M317I - all together shift to red (see table S4 of Yokoyama PNAS) - individual changes not tested
Stomiidae
barbeled dragonfishes - (family)
Aristostomias scintillans
shiny loosejaw - (species)
opsin - rhodopsin1 (RH1)
Aristostomias scintillans
shiny loosejaw - (species)
Published - Accepted by Curator
opsin - rhodopsin1-A (RH1-A)
Color vision (blue shift)
3 Mutations:
Coding
SNP
Conger myriaster
whitespotted conger - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T; Zhang H ; et al. (2008)
Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]
GP00000793
RHO
P08100
Physiology
3 mutations
Anguilla japonica
Japanese eel - (species)
Conger myriaster
whitespotted conger - (species) D
opsin - rhodopsin1-A (RH1-A)
Conger myriaster
whitespotted conger - (species)
Published - Accepted by Curator
opsin - rhodopsin1-B (RH1-B)
Color vision (blue shift)
Coding,
SNP
Anguilla japonica
Japanese eel - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Takenaka N; Agnew DW ; et al. (2005)
Elephants and human color-blind deuteranopes have identical sets of visual pigments.
1 Additional References
GP00000794
RHO
P08100
Physiology
D83N
Conger myriaster
whitespotted conger - (species)
Anguilla japonica
Japanese eel - (species) D
opsin - rhodopsin1-B (RH1-B)
Anguilla japonica
Japanese eel - (species)
Published - Accepted by Curator
pepsinogen A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001911
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
pepsinogen A
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001917
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A1
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001924
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A1
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001930
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A1
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001918
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A2
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001925
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A2
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001931
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A2
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001919
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A3
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001926
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A3
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001927
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A3
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001932
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A3
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001913
PGB
Q8SQ41
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
pepsinogen B
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
pepsinogen C
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001912
PGC
P20142
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
pepsinogen C
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
PEPT1
Anti-freezing
Coding,
Unknown
Chionodraco hamatus
Antarctic icefish - (species)
Intergeneric or Higher
Candidate Gene
Rizzello A; Romano A; Kottra G ; et al. (2013)
Protein cold adaptation strategy via a unique seven-amino acid domain in the icefish (Chionodraco ha[...]
GP00000858
slc15a1
Q804I3
Physiology
C-terminal (cytosolic) de novo VDMSRKS domain conferring cold resistance
Teleostei
teleost fishes - (infraclass)
Chionodraco hamatus
Antarctic icefish - (species)
PEPT1
Chionodraco hamatus
Antarctic icefish - (species)
Published - Accepted by Curator
Prolactin (deciduous Prolactin; dPRL)
Gene expression change (quantitative; increase)
Cis-regulatory,
SNP
Homininae
(subfamily)
Intergeneric or Higher
Candidate Gene
Emera D; Wagner GP (2012)
Transformation of a transposon into a derived prolactin promoter with function during human pregnanc[...]
GP00000926
PRL
P01236
Physiology
Acquisition of enhancer activity in transposons via several base-pair substitutions
Primates
(order)
Homininae
(subfamily)
Prolactin (deciduous Prolactin; dPRL)
Homininae
(subfamily)
Published - Accepted by Curator
Prx1 = Mhox = Prrx1
Limb length
Cis-regulatory,
Unknown
Carollia perspicillata
Seba's short-tailed bat - (species)
Intergeneric or Higher
Candidate Gene
Cretekos CJ; Wang Y; Green ED ; et al. (2008)
Regulatory divergence modifies limb length between mammals.
GP00000934
Prrx1
P63013
Morphology
Not identified
Mus musculus
house mouse - (species)
Carollia perspicillata
Seba's short-tailed bat - (species)
Prx1 = Mhox = Prrx1
Carollia perspicillata
Seba's short-tailed bat - (species)
Published - Accepted by Curator
Ptch1
Limb morphology (skeleton)
Cis-regulatory,
Unknown
Bos taurus
cattle - (species) D
Intergeneric or Higher
Candidate Gene
Lopez-Rios J; Duchesne A; Speziale D ; et al. (2014)
Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
GP00001389
Ptch1
Q61115
Morphology
LRM enhancer located between coding exons 15 and 19 at 37 kb of the transcription start site - exact causing mutation(s) unknown - Loss of activity of the LRM enhancer that normally upregulates Ptch1 expression in the limb-bud mesenchyme in response to SHH signalling
Mus musculus
house mouse - (species)
Bos taurus
cattle - (species) D
Ptch1
Bos taurus
cattle - (species)
Published - Accepted by Curator
Rhodopsin (RH1)
Color vision (blue shift)
Coding,
SNP
Thunnus orientalis
Pacific bluefin tuna - (species) D
Intergeneric or Higher
Candidate Gene
Nakamura Y; Mori K; Saitoh K ; et al. (2013)
Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna[...]
GP00001468
rho
P35359
Physiology
p.E122Q (G>C)
Percomorphaceae
(no rank)
Thunnus orientalis
Pacific bluefin tuna - (species) D
Rhodopsin (RH1)
Thunnus orientalis
Pacific bluefin tuna - (species)
Published - Accepted by Curator
ribonuclease 1B (RNase1B)
Optimal enzymatic pH
3 Mutations:
Coding
SNP
Pygathrix nemaeus
Red shanked douc langur - (species) D
Intergeneric or Higher
Candidate Gene
Zhang J (2006)
Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.
GP00000987
RNASE1B
Q8SPN3
Physiology
3 mutations
Primates
(order)
Pygathrix nemaeus
Red shanked douc langur - (species) D
ribonuclease 1B (RNase1B)
Pygathrix nemaeus
Red shanked douc langur - (species)
Published - Accepted by Curator
ribonuclease 1B (RNase1B)
Optimal enzymatic pH
3 Mutations:
Coding
SNP
Colobus guereza
mantled guereza - (species)
Intergeneric or Higher
Candidate Gene
Zhang J (2006)
Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.
GP00000988
RNASE1B
Q8SPN3
Physiology
3 mutations
Primates
(order)
Colobus guereza
mantled guereza - (species)
ribonuclease 1B (RNase1B)
Colobus guereza
mantled guereza - (species)
Published - Accepted by Curator
RNASE1B
Folivory (digestion of bacteria at low pH)
Coding,
SNP
Colobus guereza
mantled guereza - (species) D
Piliocolobus badius
western red colobus - (species) D
Intergeneric or Higher
Candidate Gene
Zhou X; Wang B; Pan Q ; et al. (2014)
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]
GP00001412
RNASE1B
Q8SPN3
Physiology
p.Arg39Trp
Macaca mulatta
Rhesus monkey - (species)
Colobus guereza
mantled guereza - (species) D
Piliocolobus badius
western red colobus - (species) D
RNASE1B
Colobus guereza
mantled guereza - (species)
Piliocolobus badius
western red colobus - (species)
Published - Accepted by Curator
RNASE1B
Folivory (digestion of bacteria at low pH)
Coding,
SNP
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
Nasalis larvatus
proboscis monkey - (species) D
Pygathrix nemaeus
Red shanked douc langur - (species) D
Intergeneric or Higher
Candidate Gene
Zhou X; Wang B; Pan Q ; et al. (2014)
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]
GP00001413
RNASE1B
Q8SPN3
Physiology
p.Arg39Trp
Colobinae
(subfamily)
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
Nasalis larvatus
proboscis monkey - (species) D
Pygathrix nemaeus
Red shanked douc langur - (species) D
RNASE1B
Rhinopithecus roxellana
golden snub-nosed monkey - (species)
Nasalis larvatus
proboscis monkey - (species)
Pygathrix nemaeus
Red shanked douc langur - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Mantella aurantiaca
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001573
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Mantella aurantiaca
(species) D
SCN4A (Nav1.4)
Mantella aurantiaca
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001574
SCN4A
P35499
Physiology
T>G p.S429A in DI-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001575
SCN4A
P35499
Physiology
A>G p.I433V in DI-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Dendrobates tinctorius
dyeing poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001576
SCN4A
P35499
Physiology
A>G p.I433V in DI-S6 domain
Anura
frogs and toads - (order)
Dendrobates tinctorius
dyeing poison frog - (species) D
SCN4A (Nav1.4)
Dendrobates tinctorius
dyeing poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Excidobates captivus
Rio Santiago poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001577
SCN4A
P35499
Physiology
A>G p.I433V in DI-S6 domain
Anura
frogs and toads - (order)
Excidobates captivus
Rio Santiago poison frog - (species) D
SCN4A (Nav1.4)
Excidobates captivus
Rio Santiago poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001578
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Dendrobates tinctorius
dyeing poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001579
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Dendrobates tinctorius
dyeing poison frog - (species) D
SCN4A (Nav1.4)
Dendrobates tinctorius
dyeing poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Excidobates captivus
Rio Santiago poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001580
SCN4A
P35499
Physiology
CC>AA p.A446E in DI-S6 domain
Anura
frogs and toads - (order)
Excidobates captivus
Rio Santiago poison frog - (species) D
SCN4A (Nav1.4)
Excidobates captivus
Rio Santiago poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Ameerega parvula
ruby poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001581
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Ameerega parvula
ruby poison frog - (species) D
SCN4A (Nav1.4)
Ameerega parvula
ruby poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Epipedobates
phantasmal poison frogs - (genus) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001582
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Epipedobates
phantasmal poison frogs - (genus) D
SCN4A (Nav1.4)
Epipedobates
phantasmal poison frogs - (genus)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates
(genus) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001583
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Phyllobates
(genus) D
SCN4A (Nav1.4)
Phyllobates
(genus)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Dendrobates tinctorius
dyeing poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001584
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Dendrobates tinctorius
dyeing poison frog - (species) D
SCN4A (Nav1.4)
Dendrobates tinctorius
dyeing poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Hyloxalus italoi
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001585
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Hyloxalus italoi
(species) D
SCN4A (Nav1.4)
Hyloxalus italoi
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Ameerega
(genus) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001586
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Ameerega
(genus) D
SCN4A (Nav1.4)
Ameerega
(genus)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Silverstoneia flotator
rainforest rocket frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001587
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Silverstoneia flotator
rainforest rocket frog - (species) D
SCN4A (Nav1.4)
Silverstoneia flotator
rainforest rocket frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001588
SCN4A
P35499
Physiology
C>A p.N1584T in DIV-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Viperidae
(family) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001652
SCN8A
A0A1B0Z7A5
Physiology
I1709V in DIV (2x resistance)
Protobothrops flavoviridis
(species)
Viperidae
(family) D
SCN8A (Nav1.6)
Viperidae
(family)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Natricinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001657
SCN8A
A0A1B0Z7B0
Physiology
V1709I (reversion) in DIV (loss of resistance)
Hebius pryeri
Pryer's keelback - (species)
Natricinae
(subfamily) D
SCN8A (Nav1.6)
Natricinae
(subfamily)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Henophidia
(superfamily) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001644
SCN9A
Q15858
Physiology
M1392T in DIII (15x resistance)
Anolis carolinensis
green anole - (species)
Henophidia
(superfamily) D
SCN9A (Nav1.7)
Henophidia
(superfamily)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Chrysemys picta
painted turtle - (species) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001645
SCN9A
Q15858
Physiology
D1393P (most probably E>P) in DIII domain (not tested)
Gallus gallus
chicken - (species)
Chrysemys picta
painted turtle - (species) D
SCN9A (Nav1.7)
Chrysemys picta
painted turtle - (species)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Carphophis
(genus) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001646
SCN9A
Q15858
Physiology
I1677V in DIV (2x resistance)
Diadophis punctatus
Ringneck snake - (species)
Carphophis
(genus) D
SCN9A (Nav1.7)
Carphophis
(genus)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Leptotyphlops
(genus) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001648
SCN9A
Q15858
Physiology
A1681G (1.5x resistance) in DIV
Anilios bituberculatus
prong-snouted blind snake - (species)
Leptotyphlops
(genus) D
SCN9A (Nav1.7)
Leptotyphlops
(genus)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Leptotyphlops
(genus) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001651
SCN9A
Q15858
Physiology
G1685Y (not tested) in DIV
Anilios bituberculatus
prong-snouted blind snake - (species)
Leptotyphlops
(genus) D
SCN9A (Nav1.7)
Leptotyphlops
(genus)
Published - Accepted by Curator
squalene synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001947
FDFT1
P37268
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
squalene synthase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
squalene synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001948
FDFT1
P37268
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
squalene synthase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SRGAP2
Neuronal maturation
Gene Amplification,
Complex Change
Primates
(order)
Intergeneric or Higher
Candidate Gene
Charrier C; Joshi K; Coutinho-Budd J ; et al. (2012)
Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation[...]
1 Additional References
GP00001077
Srgap2
Q91Z67
Physiology
Partial duplications (negative alleles)
Homo sapiens
human - (species)
Primates
(order)
SRGAP2
Primates
(order)
Published - Accepted by Curator
sterol C5 desaturase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001953
ERG3
P32353
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
sterol C5 desaturase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
sterol C5 desaturase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001954
ERG3
P32353
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
sterol C5 desaturase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
TAS1R2
Taste sensitivity (sugar)
Coding,
Deletion
N
Felidae
cat family - (family) D
Intergeneric or Higher
Candidate Gene
Li X; Li W; Wang H ; et al. (2005)
Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar.
1 Additional References
GP00001109
TAS1R2
Q8TE23
Physiology
247bp deletion in exon 3 and stop codons in exons 4 and 6. N
Mammalia
mammals - (class)
Felidae
cat family - (family) D
TAS1R2
Felidae
cat family - (family)
Published - Accepted by Curator
TAS2R16
Taste sensitivity (bitter)
Coding,
SNP
Lemur catta
Ring-tailed lemur - (species) D
Intergeneric or Higher
Candidate Gene
Itoigawa A; Hayakawa T; Suzuki-Hashido N ; et al. (2019)
A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in l[...]
GP00001956
Behavior; Physiology
Ser282Leu TCG>TTG
Varecia variegata
ruffed lemur - (species)
Eulemur macaco
black lemur - (species)
Eulemur flavifrons
Sclater's lemur - (species)
Eulemur fulvus
brown lemur - (species)
Lemur catta
Ring-tailed lemur - (species) D
TAS2R16
Lemur catta
Ring-tailed lemur - (species)
Published - Accepted by Curator
TAS2R16
Taste sensitivity (bitter)
Coding,
SNP
Varecia variegata
ruffed lemur - (species) D
Eulemur macaco
black lemur - (species) D
Eulemur fulvus
brown lemur - (species) D
Nycticebus pygmaeus
pygmy slow loris - (species) D
Intergeneric or Higher
Candidate Gene
Itoigawa A; Hayakawa T; Suzuki-Hashido N ; et al. (2019)
A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in l[...]
GP00001957
Behavior; Physiology
Ser282Leu TCG>TTG
Carlito syrichta
Philippine tarsier - (species)
Trachypithecus poliocephalus
White-headed langur - (species)
Varecia variegata
ruffed lemur - (species) D
Eulemur macaco
black lemur - (species) D
Eulemur fulvus
brown lemur - (species) D
Nycticebus pygmaeus
pygmy slow loris - (species) D
TAS2R16
Varecia variegata
ruffed lemur - (species)
Eulemur macaco
black lemur - (species)
Eulemur fulvus
brown lemur - (species)
Nycticebus pygmaeus
pygmy slow loris - (species)
Published - Accepted by Curator
TRIM5alpha-CypA chimeric gene
Pathogen resistance (retroviruses)
Other,
Insertion
Aotus
night monkeys - (genus)
Intergeneric or Higher
Candidate Gene
Sayah DM; Sokolskaja E; Berthoux L ; et al. (2004)
Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.
1 Additional References
GP00001136
TRIM5
Q9C035
Physiology
LINE-mediated retrotransposition of the CyclophilinA gene between exons 7 and 8 of TRIM5alpha
Platyrrhini
New World monkeys - (parvorder)
Aotus
night monkeys - (genus)
TRIM5alpha-CypA chimeric gene
Aotus
night monkeys - (genus)
Published - Accepted by Curator
TRIM5alpha-CypA chimeric gene
Pathogen resistance (retroviruses)
Other,
Insertion
Macaca
macaques - (genus)
Intergeneric or Higher
Candidate Gene
Stoye JP; Yap MW (2008)
Chance favors a prepared genome.
GP00001137
TRIM5
Q9C035
Physiology
LINE-mediated retrotransposition of the CyclophilinA gene into 3'UTR (exon 8) of TRIM5alpha
Cercopithecidae
Old World monkeys - (family)
Macaca
macaques - (genus)
TRIM5alpha-CypA chimeric gene
Macaca
macaques - (genus)
Published - Accepted by Curator
Uncoupling protein 1 (UCP1)
Thermoregulation (brown adipose tissue)
Coding,
Deletion
N
Sus
(genus) D
Intergeneric or Higher
Candidate Gene
Berg F; Gustafson U; Andersson L (2006)
The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor[...]
GP00001162
Ucp1
P12242
Physiology
deletion of exons 3 to 5 N
Mammalia
mammals - (class)
Sus
(genus) D
Uncoupling protein 1 (UCP1)
Sus
(genus)
Published - Accepted by Curator