Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 233 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Main Curator	Edit Gene-GePhe	Taxon B	Status	Validator Comment	Date of Sent Email
Abdominal-B	Coloration (male-specific)	Unknown, Unknown	Drosophila merina (species)	Interspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001549	Abd-B P09087	Morphology	unknown	Drosophila ercepeae (species)	Drosophila merina (species)		Abdominal-B	Drosophila merina (species)	Published - Accepted by Curator
Abdominal-B	Coloration (abdomen; male)	Cis-regulatory, Unknown	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Liu Y; Ramos-Womack M; Han C ; et al. (2019) Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.	GP00002021	Abd-B P09087	Morphology	change in the iab5 cis-regulatory element (15kb long)- exact causing mutation(s) unknown - decreased AbdB abdominal expression	Drosophila yakuba (species)	Drosophila santomea (species) D		Abdominal-B	Drosophila santomea (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (thorax)	Cis-regulatory, Unknown	Drosophila quadrilineata (species)	Interspecific	Candidate Gene	Marcellini S; Simpson P (2006) Two or four bristles: functional evolution of an enhancer of scute in Drosophilidae.	GP00000049	sc P10084	Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila quadrilineata (species)		achaete-scute complex	Drosophila quadrilineata (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (genitalia; leg sex comb)	3 Mutations: Cis-regulatory SNP	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Nagy O; Nuez I; Savisaar R ; et al. (2018) Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change.	GP00001680	sc P10084	Morphology	3 mutations	Drosophila yakuba (species)	Drosophila santomea (species) D		achaete-scute complex	Drosophila santomea (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Cis-regulatory, Unknown	Vermivora cyanoptera blue-winged warbler - (species)	Interspecific	Association Mapping	Toews DP; Taylor SA; Vallender R ; et al. (2016) Plumage Genes and Little Else Distinguish the Genomes of Hybridizing Warblers.	GP00001331	Asip Q03288	Morphology	unknown - the divergent region falls in the 5prime region that is directly upstream of the associated coding region	Vermivora chrysoptera Golden-winged warbler - (species)	Vermivora cyanoptera blue-winged warbler - (species)		Agouti (ASIP)	Vermivora cyanoptera blue-winged warbler - (species)	Published - Accepted by Curator
Agouti-related peptide 2 (agrp2)	Coloration (stripes)	Cis-regulatory, Unknown	Haplochromis sauvagei (species) Haplochromis chilotes (species)	Interspecific	Linkage Mapping	Kratochwil CF; Liang Y; Gerwin J ; et al. (2018) Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish rad[...] 1 Additional References Kratochwil CF; Liang Y; Urban S (2019) Evolutionary Dynamics of Structural Variation at a Key Locus for Color Pattern Diversification in Ci[...]	GP00001764	asip2b J3JQX9	Morphology	Causal mutation(s) are in a 1.1-kb interval within the first agrp2 intron	Pundamilia nyererei (species)	Haplochromis sauvagei (species) Haplochromis chilotes (species)		Agouti-related peptide 2 (agrp2)	Haplochromis sauvagei (species) Haplochromis chilotes (species)	Published - Accepted by Curator
Agouti-related peptide 2 (agrp2)	Coloration (stripes)	Cis-regulatory, Unknown	Haplochromis sauvagei (species) Haplochromis chilotes (species)	Interspecific	Linkage Mapping	Kratochwil CF; Liang Y; Gerwin J ; et al. (2018) Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish rad[...] 1 Additional References Kratochwil CF; Liang Y; Urban S (2019) Evolutionary Dynamics of Structural Variation at a Key Locus for Color Pattern Diversification in Ci[...]	GP00001960	asip2b J3JQX9	Morphology	Causal mutation(s) are in a 1.1-kb interval within the first agrp2 intron	Pundamilia nyererei (species)	Haplochromis sauvagei (species) Haplochromis chilotes (species)		Agouti-related peptide 2 (agrp2)	Haplochromis sauvagei (species) Haplochromis chilotes (species)	Published - Accepted by Curator
AIM22	F2 lethality	Coding, SNP	Saccharomyces bayanus (species)	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000073	AIM22 P47051	Physiology	Several candidate non-synonymous changes - exact causing mutation(s) unknown	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)		AIM22	Saccharomyces bayanus (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila yakuba (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001963	Adh P00334	Physiology	4 mutations	Drosophila santomea (species)	Drosophila yakuba (species)		alcohol dehydrogenase (Adh)	Drosophila yakuba (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila erecta (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001964	Adh P00334	Physiology	4 mutations	Drosophila orena (species)	Drosophila erecta (species)		alcohol dehydrogenase (Adh)	Drosophila erecta (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	5 Mutations:	Drosophila virilis (species) D	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001965	Adh P00334	Physiology	5 mutations	Drosophila americana (species)	Drosophila virilis (species) D		alcohol dehydrogenase (Adh)	Drosophila virilis (species)	Published - Accepted by Curator
ALX1	Beak size	Unknown, Unknown	Geospiza (genus) D	Interspecific	Association Mapping	Lamichhaney S; Berglund J; Almén MS ; et al. (2015) Evolution of Darwin's finches and their beaks revealed by genome sequencing. 1 Additional References Almén MS; Lamichhaney S; Berglund J (2016) Adaptive radiation of Darwin's finches revisited using whole genome sequencing.	GP00000081	Alx1 Q8C8B0	Morphology	240kb haplotype with complex variation	Geospiza (genus)	Geospiza (genus) D		ALX1	Geospiza (genus)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000093	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000094	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
Aquaporin	Water transport (selective accumulation of water or glycerol)	Coding, SNP	Polypedilum vanderplanki sleeping chironomid - (species)	Interspecific	Candidate Gene	Finn RN; Chauvigné F; Stavang JA ; et al. (2015) Insect glycerol transporters evolved by functional co-option and gene replacement.	GP00001421	AQP1 P29972	Physiology	p.His174Ala	Blattella germanica German cockroach - (species)	Polypedilum vanderplanki sleeping chironomid - (species)		Aquaporin	Polypedilum vanderplanki sleeping chironomid - (species)	Published - Accepted by Curator
AR	Sensory vibrissae (loss) Penile spine (loss)	Cis-regulatory, Deletion	Homo sapiens human - (species) D	Interspecific	Candidate Gene	McLean CY; Reno PL; Pollen AA ; et al. (2011) Human-specific loss of regulatory DNA and the evolution of human-specific traits.	GP00000102	AR P10275	Morphology Morphology	Enhancer loss	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D		AR	Homo sapiens human - (species)	Published - Accepted by Curator
AtLURE1	Fertilization (pollen-tube attraction by egg)	Gene Amplification, Complex Change	Arabidopsis thaliana thale cress - (species)	Interspecific	Candidate Gene	Takeuchi H; Higashiyama T (2012) A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arab[...]	GP00000126	LURE1.1 Q4VP09	Physiology	Gene birth	Arabidopsis lyrata (species)	Arabidopsis thaliana thale cress - (species)		AtLURE1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
bab	Coloration (abdomen; female)	Cis-regulatory, Unknown	Drosophila yakuba (species)	Interspecific	Candidate Gene	Rogers WA; Salomone JR; Tacy DJ ; et al. (2013) Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]	GP00002008	bab1 Q9W0K7	Morphology	causing mutation(s) unknown. Cis-regulatory element assayed with a GFP reporter in D. melanogaster.	Drosophila melanogaster fruit fly - (species)	Drosophila yakuba (species)		bab	Drosophila yakuba (species)	Published - Accepted by Curator
bab	Coloration (abdomen; female)	Cis-regulatory, Unknown	Drosophila fuyamai (species)	Interspecific	Candidate Gene	Rogers WA; Salomone JR; Tacy DJ ; et al. (2013) Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]	GP00002009	bab1 Q9W0K7	Morphology	causing mutation(s) unknown. Cis-regulatory element assayed with a GFP reporter in D. melanogaster.	Drosophila melanogaster fruit fly - (species)	Drosophila fuyamai (species)		bab	Drosophila fuyamai (species)	Published - Accepted by Curator
bab	Coloration (abdomen; female)	Cis-regulatory, Unknown	Drosophila auraria (species)	Interspecific	Candidate Gene	Rogers WA; Salomone JR; Tacy DJ ; et al. (2013) Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]	GP00002010	bab1 Q9W0K7	Morphology	causing mutation(s) unknown. Cis-regulatory element assayed with a GFP reporter in D. melanogaster.	Drosophila melanogaster fruit fly - (species)	Drosophila auraria (species)		bab	Drosophila auraria (species)	Published - Accepted by Curator
bab	Coloration (wing; male ; irridescence)	Cis-regulatory, Unknown		Interspecific	Linkage Mapping	Ficarrotta V; Hanly JJ; Loh LS ; et al. (2022) A genetic switch for male UV iridescence in an incipient species pair of sulphur butterflies.	GP00002425	bab1 Q9W0K7	Morphology	no fixed coding variation at the bab locus between the sister species. Lower expression of bab in the irridescent scale species. CRISPR bab mutants show that bab is a negative regulator of irridescent scales.	Colias philodice clouded sulphur butterfly - (species)			bab		Published - Accepted by Curator
bab1	Coloration (abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species) D	Interspecific	Candidate Gene	Williams TM; Selegue JE; Werner T ; et al. (2008) The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila[...]	GP00000131	bab1 Q9W0K7	Morphology	inter - ABD-B- and DSX- binding site spacing was reduced in regions I, II, and III gain of ABD-B binding site 13	Drosophila willistoni (species)	Drosophila melanogaster fruit fly - (species) D		bab1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (skin ; shanks)	Cis-regulatory, Unknown	Gallus sonneratii gray junglefowl - (species) D Gallus gallus chicken - (species) D	Interspecific	Linkage Mapping	Eriksson J; Larson G; Gunnarsson U ; et al. (2008) Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken. 1 Additional References Fallahshahroudi A; Sorato E; Altimiras J (2019) The Domestic BCO2 Allele Buffers Low-Carotenoid Diets in Chickens: Possible Fitness Increase Through[...]	GP00000139	BCO2 Q9BYV7	Morphology; Physiology	Not identified	Gallus gallus chicken - (species)	Gallus sonneratii gray junglefowl - (species) D Gallus gallus chicken - (species) D		BCO2 = beta-carotene oxygenase 2	Gallus sonneratii gray junglefowl - (species) Gallus gallus chicken - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Coloration (coat)	Cis-regulatory, Unknown	Vermivora cyanoptera blue-winged warbler - (species)	Interspecific	Association Mapping	Toews DP; Taylor SA; Vallender R ; et al. (2016) Plumage Genes and Little Else Distinguish the Genomes of Hybridizing Warblers.	GP00001332	BCO2 Q9BYV7	Morphology	unknown - the divergent region falls in the 5prime region that is directly upstream of the associated coding region	Vermivora chrysoptera Golden-winged warbler - (species)	Vermivora cyanoptera blue-winged warbler - (species)		BCO2 = beta-carotene oxygenase 2	Vermivora cyanoptera blue-winged warbler - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Coloration (feather)	Unknown, Unknown	Setophaga petechia yellow warbler - (species) D	Interspecific	Association Mapping	Baiz MD; Wood AW; Brelsford A ; et al. (2021) Pigmentation Genes Show Evidence of Repeated Divergence and Multiple Bouts of Introgression in Setop[...]	GP00002387	BCO2 Q9BYV7	Morphology		Setophaga pensylvanica Chestnut-sided warbler - (species)	Setophaga petechia yellow warbler - (species) D		BCO2 = beta-carotene oxygenase 2	Setophaga petechia yellow warbler - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Coloration (feather)	Unknown, Unknown	Setophaga citrina hooded warbler - (species) D	Interspecific	Association Mapping	Baiz MD; Wood AW; Brelsford A ; et al. (2021) Pigmentation Genes Show Evidence of Repeated Divergence and Multiple Bouts of Introgression in Setop[...]	GP00002388	BCO2 Q9BYV7	Morphology		Setophaga ruticilla (species)	Setophaga citrina hooded warbler - (species) D		BCO2 = beta-carotene oxygenase 2	Setophaga citrina hooded warbler - (species)	Published - Accepted by Curator
benzoic acid/salicylic acid carboxyl methyltransferase (BSMT)	Fragrance	Cis-regulatory, Unknown	Petunia axillaris (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001766	BSMT1 Q6XMI3	Physiology	Allele-specific expression in hybrids - de novo expression in P. axillaris	Petunia integrifolia subsp. inflata (subspecies)	Petunia axillaris (species) D		benzoic acid/salicylic acid carboxyl methyltransferase (BSMT)	Petunia axillaris (species)	Published - Accepted by Curator
benzoyl-CoA:benzylalcohol/2-phenylethanol benzoyltransferase (BPBT)	Fragrance	Cis-regulatory, Unknown	Petunia axillaris (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001765	BPBT A0A172W606	Physiology	Allele-specific expression in hybrids - de novo expression in P. axillaris	Petunia integrifolia subsp. inflata (subspecies)	Petunia axillaris (species) D		benzoyl-CoA:benzylalcohol/2-phenylethanol benzoyltransferase (BPBT)	Petunia axillaris (species)	Published - Accepted by Curator
BMP4 (uncertain)	Cranio-facial morphology	Unknown, Unknown	Maylandia zebra zebra mbuna - (species)	Interspecific	Linkage Mapping	Albertson RC; Streelman JT; Kocher TD ; et al. (2005) Integration and evolution of the cichlid mandible: the molecular basis of alternate feeding strategi[...] 2 Additional References Albertson RC; Streelman JT; Kocher TD (2005) Integration and evolution of the cichlid mandible: the molecular basis of alternate feeding strategi[...] Albertson RC; Kocher TD (2006) Genetic and developmental basis of cichlid trophic diversity.	GP00000153	bmp4 O13107	Morphology	Not identified	Labeotropheus fuelleborni blue mbuna - (species)	Maylandia zebra zebra mbuna - (species)		BMP4 (uncertain)	Maylandia zebra zebra mbuna - (species)	Published - Accepted by Curator
BNA1	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001878	BNA1 P47096	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D		BNA1	[Candida] glabrata (species)	Published - Accepted by Curator
BNA2	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001879	P47125NULL	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D		BNA2	[Candida] glabrata (species)	Published - Accepted by Curator
BNA4	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001880	BNA4 P38169	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D		BNA4	[Candida] glabrata (species)	Published - Accepted by Curator
BNA5	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001881	BNA5 Q05979	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D		BNA5	[Candida] glabrata (species)	Published - Accepted by Curator
BNA6	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001882	BNA6 P43619	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D		BNA6	[Candida] glabrata (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	3 Mutations: N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001391	CNL A0A172W603	Physiology	3 mutations	Petunia axillaris (species)	Petunia exserta (species) D		Cinnamate-CoA ligase 1 (CNL1)	Petunia exserta (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, SNP N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001767	CNL A0A172W603	Physiology	serine-to-arginine exchange at position 453 (T-to-A nucleotide exchange at genomic position 7 539 424) - this mutation is located immediately next to highly conserved amino acids predicted to be involved in adenosine monophosphate and coenzyme A binding; it involves two biochemically very dissimilar amino acids; and the serine at this position is conserved N	Capsella grandiflora (species)	Capsella rubella (species) D		Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, Deletion N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001768	CNL A0A172W603	Physiology	a 4 bp deletion resulting in a frameshift 795 bp downstream of the start codon and causing a premature stop codon N	Capsella grandiflora (species)	Capsella rubella (species) D		Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
csf1	Coloration	Cis-regulatory, Unknown	Oryzias woworae (species) D	Interspecific	Linkage Mapping	Ansai S; Mochida K; Fujimoto S ; et al. (2021) Genome editing reveals fitness effects of a gene for sexual dichromatism in Sulawesian fishes.	GP00002366	CSF1 P09603	Morphology		Oryzias celebensis Celebes medaka - (species)	Oryzias woworae (species) D		csf1	Oryzias woworae (species)	Published - Accepted by Curator
csf1a	Coloration (loss of stripes)	Cis-regulatory, Unknown	Danio albolineatus pearl danio - (species) D	Interspecific	Candidate Gene	Patterson LB; Bain EJ; Parichy DM (2014) Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reite[...]	GP00002123	csf1a A0A0B5JQ49	Morphology		Danio rerio zebrafish - (species)	Danio albolineatus pearl danio - (species) D		csf1a	Danio albolineatus pearl danio - (species)	Published - Accepted by Curator
CYP2J19	Coloration (feathers)	Unknown, Unknown	Serinus canaria common canary - (species)	Interspecific	Linkage Mapping	Lopes RJ; Johnson JD; Toomey MB ; et al. (2016) Genetic Basis for Red Coloration in Birds.	GP00000201	CYP2J2 P51589	Morphology	unknown	Spinus cucullatus red siskin - (species)	Serinus canaria common canary - (species)		CYP2J19	Serinus canaria common canary - (species)	Published - Accepted by Curator
CYP6B1	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio polyxenes black swallowtail - (species)	Interspecific	Candidate Gene	Li W; Schuler MA; Berenbaum MR (2003) Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Sp[...]	GP00000205	CYP6B1 Q04552	Physiology Physiology	Ile484Phe and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio polyxenes black swallowtail - (species)		CYP6B1	Papilio polyxenes black swallowtail - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	2 Mutations: Coding SNP	Mycena galopus (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002044	UQCRFS1 P47985	Physiology	2 mutations	Mycena viridimarginata (species)	Mycena galopus (species) D		cytochrome b	Mycena galopus (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	2 Mutations: Coding SNP	Strobilurus tenacellus (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002045	UQCRFS1 P47985	Physiology	2 mutations	Mycena viridimarginata (species)	Strobilurus tenacellus (species) D		cytochrome b	Strobilurus tenacellus (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	Coding, SNP	Schizosaccharomyces pombe fission yeast - (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002046	UQCRFS1 P47985	Physiology	N261D	Saccharomyces cerevisiae baker's yeast - (species)	Schizosaccharomyces pombe fission yeast - (species) D		cytochrome b	Schizosaccharomyces pombe fission yeast - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (insecticide ; bifenazate)	2 Mutations: Coding SNP	Tetranychus urticae two-spotted spider mite - (species) D	Interspecific	Candidate Gene	Van Leeuwen T; Vanholme B; Van Pottelberge S ; et al. (2008) Mitochondrial heteroplasmy and the evolution of insecticide resistance: non-Mendelian inheritance in[...]	GP00002599	UQCRFS1 P47985	Physiology	2 mutations	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		cytochrome b	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (insecticide ; bifenazate)	2 Mutations: Coding SNP	Panonychus citri citrus red mite - (species) D	Interspecific	Candidate Gene	Van Leeuwen T; Van Nieuwenhuyse P; Vanholme B ; et al. (2011) Parallel evolution of cytochrome b mediated bifenazate resistance in the citrus red mite Panonychus [...]	GP00002600	UQCRFS1 P47985	Physiology	2 mutations	Panonychus citri citrus red mite - (species)	Panonychus citri citrus red mite - (species) D		cytochrome b	Panonychus citri citrus red mite - (species)	Published - Accepted by Curator
Dat	Coloration (puparium)	Unknown, Unknown	Drosophila virilis (species)	Interspecific	Linkage Mapping	Ahmed-Braimah YH; Sweigart AL (2015) A single gene causes an interspecific difference in pigmentation in Drosophila.	GP00001403	AANAT1 Q94521	Morphology	unknown	Drosophila americana (species)	Drosophila virilis (species)		Dat	Drosophila virilis (species)	Published - Accepted by Curator
desatF	Pheromone production	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Interspecific	Candidate Gene	Legendre A; Miao XX; Da Lage JL ; et al. (2008) Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and court[...] 1 Additional References Shirangi TR; Dufour HD; Williams TM (2009) Rapid evolution of sex pheromone-producing enzyme expression in Drosophila.	GP00000219	desatF A7DZ97	Physiology	Enrichment/gain of DSX binding sites	Drosophila (subgenus)	Drosophila melanogaster fruit fly - (species)		desatF	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
desatF	Pheromone production	Cis-regulatory, Deletion	Drosophila (subgenus) D	Interspecific	Candidate Gene	Shirangi TR; Dufour HD; Williams TM ; et al. (2009) Rapid evolution of sex pheromone-producing enzyme expression in Drosophila.	GP00000220	desatF A7DZ97	Physiology	Inactivation of DSX-binding site	Drosophila takahashii (species)	Drosophila (subgenus) D		desatF	Drosophila (subgenus)	Published - Accepted by Curator
DNA replication factor CDT1	Resistance to UV irradiation	Coding, SNP	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001507	CDT1 Q9H211	Physiology	p.Ala537Val	Rhinopithecus avunculus Tonkin snub-nosed monkey - (species)	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D		DNA replication factor CDT1	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) Rhinopithecus bieti black snub-nosed monkey - (species)	Published - Accepted by Curator
DNA replication factor CDT1 [[likely pseudo-replicate of other CDT1 entry by introgression]]	Resistance to UV irradiation	Coding, SNP	Rhinopithecus roxellana golden snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001508	CDT1 Q9H211	Physiology	p.Ala537Val	Rhinopithecus brelichi Gray snub-nosed monkey - (species)	Rhinopithecus roxellana golden snub-nosed monkey - (species) D		DNA replication factor CDT1 [[likely pseudo-replicate of other CDT1 entry by introgression]]	Rhinopithecus roxellana golden snub-nosed monkey - (species)	Published - Accepted by Curator
Dopamine N-acetyltransferase (Dat)	Coloration (puparium)	Unknown, Unknown	Drosophila virilis (species) D	Interspecific	Linkage Mapping	Ahmed-Braimah YH; Sweigart AL (2015) A single gene causes an interspecific difference in pigmentation in Drosophila.	GP00000234	AANAT1 Q94521	Morphology	Not identified ; 11kb mapped interval including regulatory region and first exon	Drosophila americana (species)	Drosophila virilis (species) D		Dopamine N-acetyltransferase (Dat)	Drosophila virilis (species)	Published - Accepted by Curator
Doublesex	Bristle number (male sex comb tooth number)	Cis-regulatory, Complex Change	obscura group (species group)	Interspecific	Candidate Gene	Tanaka K; Barmina O; Sanders LE ; et al. (2011) Evolution of sex-specific traits through changes in HOX-dependent doublesex expression.	GP00000235	dsx P23023	Morphology	Acquisition of Scr binding sites in enhancer	Sophophora (subgenus)	obscura group (species group)		Doublesex	obscura group (species group)	Published - Accepted by Curator
Doublesex (or neighbouring gene prospero)	Wing shape (sex-specific)	Cis-regulatory, Unknown	Nasonia giraulti (species)	Interspecific	Linkage Mapping	Loehlin DW; Oliveira DC; Edwards R ; et al. (2010) Non-coding changes cause sex-specific wing size differences between closely related species of Nason[...]	GP00000236	dsx P23023	Morphology	various	Nasonia vitripennis jewel wasp - (species)	Nasonia giraulti (species)		Doublesex (or neighbouring gene prospero)	Nasonia giraulti (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	Cis-regulatory, Unknown	Drosophila serrata (species) D	Interspecific	Candidate Gene	Johnson WC; Ordway AJ; Watada M ; et al. (2015) Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and betwee[...]	GP00000251	e O76858	Morphology	loss of the ebony male-specific silencer function - increased expression of ebony	Drosophila jambulina (species)	Drosophila serrata (species) D		ebony	Drosophila serrata (species)	Published - Accepted by Curator
ebony	Coloration (male-specific)	Unknown, Unknown	Drosophila merina (species)	Interspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001546	e O76858	Morphology	unknown	Drosophila ercepeae (species)	Drosophila merina (species)		ebony	Drosophila merina (species)	Published - Accepted by Curator
ebony	Coloration (male-specific)	Unknown, Unknown	Drosophila bipectinata (species)	Interspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001547	e O76858	Morphology	unknown	Drosophila parabipectinata (species)	Drosophila bipectinata (species)		ebony	Drosophila bipectinata (species)	Published - Accepted by Curator
ebony	Coloration (abdomen; male)	Cis-regulatory, Insertion	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Liu Y; Ramos-Womack M; Han C ; et al. (2019) Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.	GP00002024	e O76858	Morphology	insertion of a partial 481 bp fragment related to a transposable element of the helitron class - maybe other causing mutations as well at this ebony locus (including one fixed amino acid change whose phenotypic effect has not been investigated) - increased expression associated with lighter pigmentation	Drosophila yakuba (species)	Drosophila santomea (species) D		ebony	Drosophila santomea (species)	Published - Accepted by Curator
Ectodysplasin (EDA)	Dermal bone (loss of armor plates)	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Interspecific	Linkage Mapping	Colosimo PF; Hosemann KE; Balabhadra S ; et al. (2005) Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles. 2 Additional References Jones FC; Grabherr MG; Chan YF (2012) The genomic basis of adaptive evolution in threespine sticklebacks. O'Brown NM; Summers BR; Jones FC (2015) A recurrent regulatory change underlying altered expression and Wnt response of the stickleback armo[...]	GP00000254	Eda O54693	Morphology	large haplotype- includes a T-> G regulatory change that affect expression based on differential responsiveness to Wnt signaling	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		Ectodysplasin (EDA)	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
EDAR	Scales (reduced)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002359	EDAR Q9UNE0	Morphology	Several deletions in the EDAR1 coding region. N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D		EDAR	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
EDAR	Scales (reduced)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002360	EDAR Q9UNE0	Morphology; Physiology	Deletion of a large part of the EDAR2 coding region. N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		EDAR	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
edn3b	Coloration (reduced number of stripes)	Cis-regulatory, Unknown	Danio nigrofasciatus dwarf danio - (species)	Interspecific	Candidate Gene	Spiewak JE; Bain EJ; Liu J ; et al. (2018) Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes.	GP00002124	edn3b E9QFS0	Morphology	pigment pattern differences between these species are clearly polygenic, and it seems likely that additional loci, of the endothelin pathway or other pathways, will be identified as contributing to attenuated stripes and interstripes of D. nigrofasciatus compared to D. rerio.	Danio rerio zebrafish - (species)	Danio nigrofasciatus dwarf danio - (species)		edn3b	Danio nigrofasciatus dwarf danio - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Panthera uncia snow leopard - (species) D	Interspecific	Association Mapping	Cho YS; Hu L; Hou H ; et al. (2013) The tiger genome and comparative analysis with lion and snow leopard genomes.	GP00001358	EGLN1 Q9GZT9	Physiology	p.Met39Lys	Panthera (genus)	Panthera uncia snow leopard - (species) D		EGLN1	Panthera uncia snow leopard - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Heterocephalus glaber naked mole-rat - (species) D	Interspecific	Association Mapping	Kim EB; Fang X; Fushan AA ; et al. (2011) Genome sequencing reveals insights into physiology and longevity of the naked mole rat.	GP00001759	EGLN1 Q9GZT9	Physiology	unique amino-acid changes in different positions of EGLN1 (Pro15, Arg17 and Arg36)	Rodentia rodent - (order)	Heterocephalus glaber naked mole-rat - (species) D		EGLN1	Heterocephalus glaber naked mole-rat - (species)	Published - Accepted by Curator
EPAS1	Hypoxia response	Coding, SNP	Panthera uncia snow leopard - (species) D	Interspecific	Association Mapping	Cho YS; Hu L; Hou H ; et al. (2013) The tiger genome and comparative analysis with lion and snow leopard genomes.	GP00001357	EPAS1 Q99814	Physiology	two species-specific amino acid changes: Val663Ile and Cys794Arg - whether both or only one is affecting the phenotype is unknown	Panthera (genus)	Panthera uncia snow leopard - (species) D		EPAS1	Panthera uncia snow leopard - (species)	Published - Accepted by Curator
ephrin-a4	Coloration (scales)	Unknown, Unknown	Tropheops sp. 'red cheek' (species)	Interspecific	Linkage Mapping	Albertson RC; Powder KE; Hu Y ; et al. (2014) Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichl[...]	GP00001420	EFNA4 P52798	Morphology	unknown	Labeotropheus fuelleborni blue mbuna - (species)	Tropheops sp. 'red cheek' (species)		ephrin-a4	Tropheops sp. 'red cheek' (species)	Published - Accepted by Curator
Fads2	Fatty acid metabolism (fatty acid desaturation)	Gene Amplification, Insertion	Gasterosteus aculeatus three-spined stickleback - (species) D	Interspecific	Linkage Mapping	Ishikawa A; Kabeya N; Ikeya K ; et al. (2019) A key metabolic gene for recurrent freshwater colonization and radiation in fishes.	GP00001959	fads2 Q9DEX7	Physiology	Fads2 locus is duplicated in G. aculeatus increasing DHA intake and the propensity to invade of freshwater environments. The ancestral copy is on linkage group 19 and the derived copy is on linkage group 12.	Gasterosteus nipponicus (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		Fads2	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Fads2	Fatty acid metabolism (fatty acid desaturation)	Gene Amplification, Insertion	Pungitius tymensis Sakhalin sticlkeback - (species) D Pungitius kaibarae (species) D	Interspecific	Candidate Gene	Ishikawa A; Kabeya N; Ikeya K ; et al. (2019) A key metabolic gene for recurrent freshwater colonization and radiation in fishes.	GP00002053	fads2 Q9DEX7	Physiology	higher number of copies of Fads2.	Pungitius pungitius ninespine stickleback - (species)	Pungitius tymensis Sakhalin sticlkeback - (species) D Pungitius kaibarae (species) D		Fads2	Pungitius tymensis Sakhalin sticlkeback - (species) Pungitius kaibarae (species)	Published - Accepted by Curator
Fas2	Pupation site choice	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Pischedda A; Shahandeh MP; Turner TL (2020) The Loci of Behavioral Evolution: Evidence That Fas2 and tilB Underlie Differences in Pupation Site [...]	GP00002345	Fas2 P34082	Behavior	Gene identified via deficiency mapping. RNAi in D. melanogaster leads to pupae pupating closer to the food.	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Fas2	Drosophila simulans (species)	Published - Accepted by Curator
fatty acid synthase	Dessication tolerance Pheromone production (mbCHC)	Cis-regulatory, Unknown	Drosophila birchii (species)	Interspecific	Candidate Gene	Chung H; Loehlin DW; Dufour HD ; et al. (2014) A single gene affects both ecological divergence and mate choice in Drosophila.	GP00002063	FASN3 Q7PLB8	Physiology Physiology	No expression of the gene in D. birchii. The coding region of the D. birchii gene is intact. Cis-regulatory region tested in reporter assays in D. melanogaster - exact causing mutation(s) unknown. RNAi against mFAS/CG17354 in D. serrata recapitylates the D. birchii phenotype.	Drosophila serrata (species)	Drosophila birchii (species)		fatty acid synthase	Drosophila birchii (species)	Published - Accepted by Curator
Fidgetin-like1 (Fignl1)	Testis size (testis weight ; spermatogenesis)	Unknown, Unknown	Mus musculus house mouse - (species)	Interspecific	Linkage Mapping	L'Hôte D; Vatin M; Auer J ; et al. (2011) Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced tes[...]	GP00001668	Fignl1 Q8BPY9	Physiology	Several non-synonymous SNPs and an alternative splicing encoding a truncated isoform that may act as a competitor of the full length protein in the degradation process	Mus spretus western wild mouse - (species)	Mus musculus house mouse - (species)		Fidgetin-like1 (Fignl1)	Mus musculus house mouse - (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Gene Loss, Complex Change N	Iochroma cyaneum (species)	Interspecific	Linkage Mapping	Smith SD; Rausher MD (2011) Gene loss and parallel evolution contribute to species difference in flower color.	GP00000324	CYP75A2 P37120	Morphology	Large deletion N	Iochroma cyaneum (species)	Iochroma cyaneum (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Iochroma cyaneum (species)	Published - Accepted by Curator
fog-2	Fertility (self-fertility; hermaphrodite spermatogenesis)	Gene Amplification, Complex Change	Caenorhabditis elegans (species)	Interspecific	Candidate Gene	Nayak S; Goree J; Schedl T (2005) fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis.	GP00000349	fog-2 Q2YS43	Physiology	Gene birth by duplication of an ancestral gene ; FOG-2 binds the translational regulator GLD-1 and promotes spermatogenesis ; see also tra-2 entry and associated references	Caenorhabditis briggsae (species)	Caenorhabditis elegans (species)		fog-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
FoxP2	Gene expression change (transcriptional targets)	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Konopka G; Bomar JM; Winden K ; et al. (2009) Human-specific transcriptional regulation of CNS development genes by FOXP2. 1 Additional References Schreiweis C; Bornschein U; Burguière E (2014) Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural perform[...]	GP00000353	FOXP2 O15409	Behavior	2 aa changes (T303N and N325S) resulting in changes of the regulated transcriptional targets in a human neuron cell line. Speculatively; these changes could be associated with language skills but these connections with null-mutant phenotypes are dubious - whether one or both mutations are required is unknown	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D		FoxP2	Homo sapiens human - (species)	Published - Accepted by Curator
FRIZZLED8	Neocortex development	Cis-regulatory, Unknown	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Boyd JL; Skove SL; Rouanet JP ; et al. (2015) Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocorte[...]	GP00001443	FZD8 Q9H461	Morphology	10 mutations fixed on the human branch in the Hs-HARE5 genomic locus resulting in enhancer activity in developing neocortex	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D		FRIZZLED8	Homo sapiens human - (species)	Published - Accepted by Curator
GADD45G	Brain development	Cis-regulatory, Deletion	Pan troglodytes chimpanzee - (species) D	Interspecific	Association Mapping	McLean CY; Reno PL; Pollen AA ; et al. (2011) Human-specific loss of regulatory DNA and the evolution of human-specific traits.	GP00000384	GADD45G O95257	Morphology	Enhancer loss	Homo sapiens human - (species)	Pan troglodytes chimpanzee - (species) D		GADD45G	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
GAL1	Carbohydrate metabolism	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Candidate Gene	Roop JI; Chang KC; Brem RB (2016) Polygenic evolution of a sugar specialization trade-off in yeast.	GP00001425	GAL1 P04385	Physiology	unknown	Saccharomyces bayanus (species)	Saccharomyces cerevisiae baker's yeast - (species) D		GAL1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
GAL10	Carbohydrate metabolism	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Candidate Gene	Roop JI; Chang KC; Brem RB (2016) Polygenic evolution of a sugar specialization trade-off in yeast.	GP00001428	GAL10 P04397	Physiology	unknown	Saccharomyces bayanus (species)	Saccharomyces cerevisiae baker's yeast - (species) D		GAL10	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
GAL3	Carbohydrate metabolism	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Candidate Gene	Roop JI; Chang KC; Brem RB (2016) Polygenic evolution of a sugar specialization trade-off in yeast.	GP00001426	GAL3 P13045	Physiology	unknown	Saccharomyces bayanus (species)	Saccharomyces cerevisiae baker's yeast - (species) D		GAL3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
GAL4	Carbohydrate metabolism	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Candidate Gene	Roop JI; Chang KC; Brem RB (2016) Polygenic evolution of a sugar specialization trade-off in yeast.	GP00001427	GAL4 P04386	Physiology	unknown	Saccharomyces bayanus (species)	Saccharomyces cerevisiae baker's yeast - (species) D		GAL4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
gfzf	Hybrid incompatibility (F1 male lethality)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Phadnis N; Baker EP; Cooper JC ; et al. (2015) An essential cell cycle regulation gene causes hybrid inviability in Drosophila.	GP00000392	gfzf Q6NP69	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		gfzf	Drosophila simulans (species)	Published - Accepted by Curator
GPX2	Xenobiotic resistance (citrinin)	Cis-regulatory, Unknown	Saccharomyces paradoxus (species) D	Interspecific	Association Mapping	Naranjo S; Smith JD; Artieri CG ; et al. (2015) Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.	GP00001310	GPX2 P38143	Physiology	mutations within 1kb in promotor region	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces paradoxus (species) D		GPX2	Saccharomyces paradoxus (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002354	opn1mw1 Q9W6A5	Physiology	Rh2-1 coding sequence absent from the full genome sequence of the three Sinocyclocheilus species N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D		Green-sensitive opsin (RH2)	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002355	opn1mw4 Q9W6A6	Physiology	Rh2-4 coding sequence absent from the full genome sequence of S. anshuiensis but present in the genome of Sinocyclocheilus rhinocerous and S. grahami N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		Green-sensitive opsin (RH2)	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002356	opn1mw2 Q8AYM8	Physiology	Rh2-2 coding sequence absent from the full genome sequence of the three Sinocyclocheilus species N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D		Green-sensitive opsin (RH2)	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, Deletion N	Sorghum (genus) D	Interspecific	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001409	CO Q39057	Physiology	80bp deletion in first exon leading to gene frameshift N	Sorghum (genus)	Sorghum (genus) D		Heading Date 1 (HD1)	Sorghum (genus)	Published - Accepted by Curator
heavy metal atpase4 (HMA4)	Metal tolerance	Unknown, Unknown	Arabidopsis halleri (species) D	Interspecific	Linkage Mapping	Courbot M; Willems G; Motte P ; et al. (2007) A major quantitative trait locus for cadmium tolerance in Arabidopsis halleri colocalizes with HMA4,[...]	GP00000447	HMA4 O64474	Physiology	unknown	Arabidopsis lyrata (species)	Arabidopsis halleri (species) D		heavy metal atpase4 (HMA4)	Arabidopsis halleri (species)	Published - Accepted by Curator
heavy metal atpase4 (HMA4)	Metal tolerance	Gene Amplification, Complex Change	Arabidopsis halleri (species)	Interspecific	Linkage Mapping	Hanikenne M; Talke IN; Haydon MJ ; et al. (2008) Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4. 1 Additional References Hanikenne M; Kroymann J; Trampczynska A (2013) Hard selective sweep and ectopic gene conversion in a gene cluster affording environmental adaptatio[...]	GP00000448	HMA4 O64474	Physiology	Gene duplication	Arabidopsis thaliana thale cress - (species)	Arabidopsis halleri (species)		heavy metal atpase4 (HMA4)	Arabidopsis halleri (species)	Published - Accepted by Curator
heavy metal atpase4 (HMA4)	Metal tolerance	Cis-regulatory, Unknown	Arabidopsis halleri (species)	Interspecific	Linkage Mapping	Hanikenne M; Talke IN; Haydon MJ ; et al. (2008) Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4. 1 Additional References Hanikenne M; Kroymann J; Trampczynska A (2013) Hard selective sweep and ectopic gene conversion in a gene cluster affording environmental adaptatio[...]	GP00000449	HMA4 O64474	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis halleri (species)		heavy metal atpase4 (HMA4)	Arabidopsis halleri (species)	Published - Accepted by Curator
hemoglobin; HBA	Hypoxia response	Coding, SNP	Lama (genus)	Interspecific	Candidate Gene	Kleinschmidt T; März J; Jürgens KD ; et al. (1986) Interaction of allosteric effectors with alpha-globin chains and high altitude respiration of mammal[...]	GP00000454	HBA1 P69905	Physiology	Asp122His	Mammalia mammals - (class)	Lama (genus)		hemoglobin; HBA	Lama (genus)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000460	HBA1 P69905	Physiology	Ala77Thr	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000461	HBAD P02001	Physiology	Val96Ala	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anser indicus bar-headed goose - (species) D	Interspecific	Candidate Gene	Jessen TH; Weber RE; Fermi G ; et al. (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...] 2 Additional References McCracken KG; Barger CP; Bulgarella M (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. McCracken KG; Barger CP; Sorenson MD (2010) Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin gen[...]	GP00000462	HBA1 P69905	Physiology	Pro119Ala	Anser anser domestic goose - (species)	Anser indicus bar-headed goose - (species) D		hemoglobin; HBA2	Anser indicus bar-headed goose - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	2 Mutations: Coding SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000465	HBAD P02001	Physiology	2 mutations	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBA2	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas puna (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000469	HBB P68871	Physiology	2 mutations	Anas ducks - (genus)	Anas puna (species) D		hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Lophonetta specularioides crested duck - (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000470	HBB P68871	Physiology	2 mutations	Anatidae waterfowl - (family)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000471	HBB P68871	Physiology	Asp94Glu	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Jessen TH; Weber RE; Fermi G ; et al. (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...] 2 Additional References McCracken KG; Barger CP; Bulgarella M (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. McCracken KG; Barger CP; Sorenson MD (2010) Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin gen[...]	GP00000473	HBB P68871	Physiology	Leu55Ser	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000474	HBB P68871	Physiology	Ala86Ser	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	3 Mutations: Coding SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000475	HBA1 P69905	Physiology	3 mutations	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
Hybrid male rescue	Hybrid incompatibility (F1 male lethality)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Brideau NJ; Flores HA; Wang J ; et al. (2006) Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.	GP00000495	Hmr Q86CW5	Physiology	Rapid coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Hybrid male rescue	Drosophila simulans (species)	Published - Accepted by Curator
Inhibitor of DNA binding 3 (id3)	Lifespan	Coding, Deletion	Nothobranchius pienaari (species) D	Interspecific	Association Mapping	Reichwald K; Petzold A; Koch P ; et al. (2015) Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.	GP00001677	ID3 Q02535	Physiology	One evolutionarily conserved aa (E) is deleted in id3 C-terminus	Nothobranchius rachovii bluefin notho - (species)	Nothobranchius pienaari (species) D		Inhibitor of DNA binding 3 (id3)	Nothobranchius pienaari (species)	Published - Accepted by Curator
InR	Fertility (ovariole number)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Green DA; Extavour CG (2012) Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...] 1 Additional References Orgogozo V; Broman KW; Stern DL (2006) High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number [...]	GP00000500	InR P09208	Physiology	unknown; loss of function reduces ovariole number	Drosophila sechellia (species)	Drosophila simulans (species)		InR	Drosophila simulans (species)	Published - Accepted by Curator
interleukin-4	Immune response	Cis-regulatory, SNP	Homo sapiens human - (species)	Interspecific	Candidate Gene	Rockman MV; Hahn MW; Soranzo N ; et al. (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression.	GP00000504	IL4R P24394	Physiology	1bp substitution in promoter	Primates (order)	Homo sapiens human - (species)		interleukin-4	Homo sapiens human - (species)	Published - Accepted by Curator
Ir75a	Olfaction	Coding, SNP	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Prieto-Godino LL; Rytz R; Bargeton B ; et al. (2016) Olfactory receptor pseudo-pseudogenes.	GP00001701	Ir75a Q9VVL1	Physiology	T289S and/or Q536K and/or F538L - introduction of these three amino acid changes in the D. melanogaster protein is sufficient to confer response indistinguishable from the one of D. sechellia	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D		Ir75a	Drosophila sechellia (species)	Published - Accepted by Curator
Ir75b	Olfaction	Coding, SNP	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Prieto-Godino LL; Rytz R; Cruchet S ; et al. (2017) Evolution of Acid-Sensing Olfactory Circuits in Drosophilids.	GP00001702	Ir75b B7Z069	Physiology	T523S in the LBD domain - caused by C1568G	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D		Ir75b	Drosophila sechellia (species)	Published - Accepted by Curator
Isocitrate dehydrogenase (NADP) (IDH)	Temperature tolerance (temperature range)	2 Mutations: Coding SNP	Mytilus trossulus common blue mussel - (species)	Interspecific	Candidate Gene	Lockwood BL; Somero GN (2012) Functional determinants of temperature adaptation in enzymes of cold- versus warm-adapted mussels (G[...]	GP00000506	I1VYX2	Physiology	2 mutations	Mytilus galloprovincialis Mediterranean mussel - (species)	Mytilus trossulus common blue mussel - (species)		Isocitrate dehydrogenase (NADP) (IDH)	Mytilus trossulus common blue mussel - (species)	Published - Accepted by Curator
JYalpha	Hybrid incompatibility (F2 male sterility)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Masly JP; Jones CD; Noor MA ; et al. (2006) Gene transposition as a cause of hybrid sterility in Drosophila.	GP00000508	JYalpha A8QI34	Physiology	Gene transposition	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		JYalpha	Drosophila simulans (species)	Published - Accepted by Curator
Kcnj13	Coloration	Unknown, Unknown	Danio aesculapii (species) D	Interspecific	Candidate Gene	Podobnik M; Frohnhöfer HG; Dooley CM ; et al. (2020) Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fis[...]	GP00002364	Kcnj13 P86046	Morphology		Danio rerio zebrafish - (species)	Danio aesculapii (species) D		Kcnj13	Danio aesculapii (species)	Published - Accepted by Curator
lbh (limb bud and heart homolog)	Cranio-facial morphology (mandible)	Coding, SNP	Labeotropheus fuelleborni blue mbuna - (species) D	Interspecific	Linkage Mapping	Powder KE; Cousin H; McLinden GP ; et al. (2014) A nonsynonymous mutation in the transcriptional regulator lbh is associated with cichlid craniofacia[...]	GP00001387	LBH Q53QV2	Morphology	G>A p.R17Q	Maylandia zebra zebra mbuna - (species)	Labeotropheus fuelleborni blue mbuna - (species) D		lbh (limb bud and heart homolog)	Labeotropheus fuelleborni blue mbuna - (species)	Published - Accepted by Curator
Lethal Hybrid rescue	Hybrid incompatibility (F1 male lethality)	Coding, Insertion	Drosophila simulans (species) D	Interspecific	Linkage Mapping	Brideau NJ; Flores HA; Wang J ; et al. (2006) Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. 2 Additional References Nolte V; Weigel D; Schlötterer C (2008) The impact of shared ancestral variation on hybrid male lethality--a 16 codon indel in the Drosophil[...] Maheshwari S; Barbash DA (2012) An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]	GP00000540	Lhr Q95RV3	Physiology	16a.a. insertion with effect in sensitive background only (Maheshwari and Barbash 2012)	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species) D		Lethal Hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator
Lethal Hybrid rescue	Hybrid incompatibility (F1 male lethality)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Maheshwari S; Barbash DA (2012) An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]	GP00000541	Lhr Q95RV3	Physiology	Coding divergence in a conserved stretch of 10 C-terminal amino-acids	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Lethal Hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator
LIGHT AREAS1 (LAR1)	Coloration (flowers)	Cis-regulatory, Unknown	Erythranthe lewisii (species)	Interspecific	Linkage Mapping	Yuan YW; Rebocho AB; Sagawa JM ; et al. (2016) Competition between anthocyanin and flavonol biosynthesis produces spatial pattern variation of flor[...]	GP00000543	LAR1 A0A0S2T0F2	Morphology	unknown	Erythranthe lewisii (species)	Erythranthe lewisii (species)		LIGHT AREAS1 (LAR1)	Erythranthe lewisii (species)	Published - Accepted by Curator
LIMONENE-MYRCENE SYNTHASE (LMS)	Fragrance (floral terpenoid volatiles; D -limonene and beta-myrcene)	Coding, SNP N	Erythranthe cardinalis (species) D	Interspecific	Linkage Mapping	Byers KJ; Vela JP; Peng F ; et al. (2014) Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...]	GP00001761	LMS W6A2K5	Physiology	G66T transversion mutation in exon 3 of McLMS (KM659024) that results in a nonsense mutation in the McLMS protein (G201X) N	Erythranthe lewisii (species)	Erythranthe cardinalis (species) D		LIMONENE-MYRCENE SYNTHASE (LMS)	Erythranthe cardinalis (species)	Published - Accepted by Curator
lin-48	Excretory duct position	4 Mutations: Cis-regulatory Unknown	Caenorhabditis elegans (species) D	Interspecific	Candidate Gene	Wang X; Chamberlin HM (2002) Multiple regulatory changes contribute to the evolution of the Caenorhabditis lin-48 ovo gene. 1 Additional References Wang X; Chamberlin HM (2004) Evolutionary innovation of the excretory system in Caenorhabditis elegans.	GP00000544	lin-48 G5EDU6	Morphology	4 mutations	Caenorhabditis briggsae (species) Caenorhabditis remanei (species) Caenorhabditis japonica (species)	Caenorhabditis elegans (species) D		lin-48	Caenorhabditis elegans (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	2 Mutations: Coding SNP	Vulpes lagopus Arctic fox - (species)	Interspecific	Candidate Gene	Våge DI; Fuglei E; Snipstad K ; et al. (2005) Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) [...] 1 Additional References Liu Z; Gong Y; Feng M (2016) Genetic variations of the coding region of the melanocortin receptor 1 (MC1R) gene in the fox.	GP00000569	MC1R Q01726	Morphology	2 mutations	Vulpes vulpes red fox - (species)	Vulpes lagopus Arctic fox - (species)		MC1R	Vulpes lagopus Arctic fox - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus poschiavinus (species)	Interspecific	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000583	MC1R Q01726	Morphology	S69L	Mus musculus house mouse - (species)	Mus poschiavinus (species)		MC1R	Mus poschiavinus (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Rattus rattus black rat - (species)	Interspecific	Candidate Gene	Kambe Y; Tanikawa T; Matsumoto Y ; et al. (2011) Origin of agouti-melanistic polymorphism in Wild Black Rats (Rattus rattus) inferred from Mc1r gene [...]	GP00000595	MC1R Q01726	Morphology	Glu93Lys	Rattus tanezumi Oriental house rat - (species)	Rattus rattus black rat - (species)		MC1R	Rattus rattus black rat - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	3 Mutations: Coding SNP	Ramphastos dicolorus (species) D Ramphastos vitellinus (species) D Ramphastos tucanus (species) D Ramphastos toco (species) D	Interspecific	Candidate Gene	Corso J; Mundy NI; Fagundes NJ ; et al. (2016) Evolution of dark colour in toucans (Ramphastidae): a case of molecular adaptation?	GP00001367	Mc1r Q01727	Morphology	3 mutations	Ramphastidae (family)	Ramphastos dicolorus (species) D Ramphastos vitellinus (species) D Ramphastos tucanus (species) D Ramphastos toco (species) D		MC1R	Ramphastos dicolorus (species) Ramphastos vitellinus (species) Ramphastos tucanus (species) Ramphastos toco (species)	Published - Accepted by Curator
metal tolerance protein1	Metal tolerance	Gene Amplification, Complex Change	Arabidopsis halleri (species) D	Interspecific	Linkage Mapping	Dräger DB; Desbrosses-Fonrouge AG; Krach C ; et al. (2004) Two genes encoding Arabidopsis halleri MTP1 metal transport proteins co-segregate with zinc toleranc[...] 1 Additional References Dräger DB; Desbrosses-Fonrouge AG; Krach C (2004) Two genes encoding Arabidopsis halleri MTP1 metal transport proteins co-segregate with zinc toleranc[...]	GP00000652	MTP1 Q9ZT63	Physiology	Copy number Variant	Arabidopsis lyrata (species)	Arabidopsis halleri (species) D		metal tolerance protein1	Arabidopsis halleri (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Papio anubis olive baboon - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001452	MAVS Q7Z434	Physiology	Cys508Arg disrupting the protease cleavage site	Miopithecus talapoin talapoin - (species)	Papio anubis olive baboon - (species) D		Mitochondrial antiviral signaling (MAVS)	Papio anubis olive baboon - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Macaca mulatta Rhesus monkey - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001453	MAVS Q7Z434	Physiology	Val506Gly resistant to cleavage	Miopithecus talapoin talapoin - (species)	Macaca mulatta Rhesus monkey - (species) D		Mitochondrial antiviral signaling (MAVS)	Macaca mulatta Rhesus monkey - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Ateles geoffroyi black-handed spider monkey - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001454	MAVS Q7Z434	Physiology	Val506Ala resistant to cleavage	Lagothrix lagotricha brown woolly monkey - (species)	Ateles geoffroyi black-handed spider monkey - (species) D		Mitochondrial antiviral signaling (MAVS)	Ateles geoffroyi black-handed spider monkey - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Plecturocebus moloch red-bellied titi - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001455	MAVS Q7Z434	Physiology	Val506Ala resistant to cleavage	Lagothrix lagotricha brown woolly monkey - (species)	Plecturocebus moloch red-bellied titi - (species) D		Mitochondrial antiviral signaling (MAVS)	Plecturocebus moloch red-bellied titi - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Allenopithecus nigroviridis Allen's swamp monkey - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001456	MAVS Q7Z434	Physiology	Val506Met less susceptible to cleavage	Erythrocebus patas red guenon - (species)	Allenopithecus nigroviridis Allen's swamp monkey - (species) D		Mitochondrial antiviral signaling (MAVS)	Allenopithecus nigroviridis Allen's swamp monkey - (species)	Published - Accepted by Curator
Mpv17	Coloration (albinism; iridophores)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002358	mpv17 Q5TZ51	Morphology; Physiology	Deletion which removes 16 amino acids in a conserved region. The Mpv17 mutant in zebrafish displays a strong reduction of iridophores throughout larval and adult stages. N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		Mpv17	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
MRS1	F2 lethality	3 Mutations: Coding SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000678	MRS1 P07266	Physiology	3 mutations	Saccharomyces paradoxus (species) Saccharomyces bayanus (species) Saccharomyces kudriavzevii (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MRS1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MYB-FL	Coloration (flower ; UV absorbance)	Cis-regulatory, Insertion	Petunia axillaris (species) D	Interspecific	Linkage Mapping	Sheehan H; Moser M; Klahre U ; et al. (2016) MYB-FL controls gain and loss of floral UV absorbance, a key trait affecting pollinator preference a[...]	GP00001589	MYB-FL A0A0S3CVD3	Morphology	A 977-kb insertion 12 bp upstream of the predicted TATA-binding box is causing upregulation of the promoter	Petunia integrifolia (species)	Petunia axillaris (species) D		MYB-FL	Petunia axillaris (species)	Published - Accepted by Curator
MYB-FL	Coloration (flower ; UV absorbance)	Coding, Deletion N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Sheehan H; Moser M; Klahre U ; et al. (2016) MYB-FL controls gain and loss of floral UV absorbance, a key trait affecting pollinator preference a[...]	GP00001590	MYB-FL A0A0S3CVC7	Morphology	A 1-bp deletion in exon 3 causing a frameshift resulting in a truncated protein N	Petunia axillaris (species)	Petunia exserta (species) D		MYB-FL	Petunia exserta (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Varanus salvator water monitor - (species) D Varanus niloticus (species) D Varanus albigularis cape monitor - (species) D	Interspecific	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000699	Atp1a1 Q8VDN2	Physiology	2 mutations	Varanus tristis (species) Varanus mitchelli (species) Varanus scalaris (species)	Varanus salvator water monitor - (species) D Varanus niloticus (species) D Varanus albigularis cape monitor - (species) D		Na/K-ATPase alpha-subunit	Varanus salvator water monitor - (species) Varanus niloticus (species) Varanus albigularis cape monitor - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	4 Mutations: Coding SNP	Chrysochus auratus dogbane beetle - (species) D	Interspecific	Candidate Gene	Aardema ML; Zhen Y; Andolfatto P (2012) The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies. 1 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000704	Atp1a1 Q8VDN2	Physiology	4 mutations	Coleoptera beetles - (order)	Chrysochus auratus dogbane beetle - (species) D		Na/K-ATPase alpha-subunit	Chrysochus auratus dogbane beetle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Rhyssomatus lineaticollis (species) D	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community.	GP00000705	K+ ATPase alpha subunit R4ZHW8	Physiology	C104Y	Coleoptera beetles - (order)	Rhyssomatus lineaticollis (species) D		Na/K-ATPase alpha-subunit	Rhyssomatus lineaticollis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Tetraopes tetrophthalmus red milkweed beetle - (species) D	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000706	Atp1a1 Q8VDN2	Physiology	2 mutations	Coleoptera beetles - (order)	Tetraopes tetrophthalmus red milkweed beetle - (species) D		Na/K-ATPase alpha-subunit	Tetraopes tetrophthalmus red milkweed beetle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides; ouabaine)	4 Mutations: Coding SNP	Danaus plexippus monarch butterfly - (species) D Danaus erippus (species) D	Interspecific	Candidate Gene	Aardema ML; Zhen Y; Andolfatto P (2012) The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies. 3 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] Taverner AM; Yang L; Barile ZJ (2019) Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vi[...] Karageorgi M; Groen SC; Sumbul F (2019) Genome editing retraces the evolution of toxin resistance in the monarch butterfly.	GP00000707	Atp1a1 Q8VDN2	Physiology	4 mutations	Nymphalidae brushfoots - (family)	Danaus plexippus monarch butterfly - (species) D Danaus erippus (species) D		Na/K-ATPase alpha-subunit	Danaus plexippus monarch butterfly - (species) Danaus erippus (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Liriomyza asclepiadis (species) D	Interspecific	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000711	Atp1a1 Q8VDN2	Physiology	N122H	Insecta true insects - (class)	Liriomyza asclepiadis (species) D		Na/K-ATPase alpha-subunit	Liriomyza asclepiadis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Aphis nerii oleander aphid - (species)	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community.	GP00000712	K+ ATPase alpha subunit R4ZHW8	Physiology	2 mutations	Insecta true insects - (class)	Aphis nerii oleander aphid - (species)		Na/K-ATPase alpha-subunit	Aphis nerii oleander aphid - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000713	Atp1a1 Q8VDN2	Physiology	Q111L	Lepidoptera butterflies and moths - (order)	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)		Na/K-ATPase alpha-subunit	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Varanus varius lace monitor - (species) D Varanus tristis (species) D Varanus scalaris (species) D	Interspecific	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000715	Atp1a1 Q8VDN2	Physiology	2 mutations	Varanus salvator water monitor - (species) Varanus rudicollis roughneck monitor - (species) Varanus dumerilii Dumeril monitor - (species)	Varanus varius lace monitor - (species) D Varanus tristis (species) D Varanus scalaris (species) D		Na/K-ATPase alpha-subunit	Varanus varius lace monitor - (species) Varanus tristis (species) Varanus scalaris (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Liriomyza (genus) D	Interspecific	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00001741	Atp1a1 Q8VDN2	Physiology	Q111L	Phytomyzinae (subfamily)	Liriomyza (genus) D		Na/K-ATPase alpha-subunit	Liriomyza (genus)	Published - Accepted by Curator
Neverland	Cholesterol metabolism Ecological specialization	4 Mutations: Coding SNP	Drosophila pachea (species) D	Interspecific	Candidate Gene	Lang M; Murat S; Clark AG ; et al. (2012) Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.	GP00000738	nvd Q1JUZ1	Physiology Physiology	4 mutations	Drosophila acanthoptera (species)	Drosophila pachea (species) D	Courtier Virginie	Neverland	Drosophila pachea (species)	Published - Accepted by Curator	would be good to add text	March 8, 2019 10:00
Nup160	Hybrid incompatibility (F1 male sterility)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Tang S; Presgraves DC (2009) Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.	GP00000742	Nup160 Q9VKJ3	Physiology	Coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Nup160	Drosophila simulans (species)	Published - Accepted by Curator
Nup96	Hybrid incompatibility (F1 male sterility)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Presgraves DC; Balagopalan L; Abmayr SM ; et al. (2003) Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.	GP00000743	NUP96 Q8LLD0	Physiology	Coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Nup96	Drosophila simulans (species)	Published - Accepted by Curator
NV10127-NV10128-NV10129 gene cluster	Pheromone production (isomeric/chirality divergence)	Unknown, Unknown	Nasonia giraulti (species)	Interspecific	Linkage Mapping	Niehuis O; Buellesbach J; Gibson JD ; et al. (2013) Behavioural and genetic analyses of Nasonia shed light on the evolution of sex pheromones.	GP00000744	NV10127 L8BRU0	Physiology	Not identified. Gene conversion between the three paralogues in tandem	Nasonia vitripennis jewel wasp - (species)	Nasonia giraulti (species)		NV10127-NV10128-NV10129 gene cluster	Nasonia giraulti (species)	Published - Accepted by Curator
ocimene synthase (OS)	Pheromone production (cuticular hydrocarbons ; beta-ocimene)	Coding, Unknown	Heliconius cydno (species) D	Interspecific	Linkage Mapping	Darragh K; Orteu A; Black D ; et al. (2021) A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between close[...]	GP00002426	TPS A0A7D0AGU9	Physiology	gain of expression - in vitro assay of the protein activity in E. coli - several amino acid changes between the 2 species	Heliconius melpomene postman butterfly - (species)	Heliconius cydno (species) D		ocimene synthase (OS)	Heliconius cydno (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, SNP N	Erythranthe cardinalis (species) D	Interspecific	Linkage Mapping	Byers KJ; Vela JP; Peng F ; et al. (2014) Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...] 1 Additional References Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001760	TPS02 P0CJ43	Physiology	multiple candidate coding sequence differences - together they eliminate the ability of the enzyme to produce E-beta-ocimene - effect of individual mutations not tested N	Erythranthe lewisii (species)	Erythranthe cardinalis (species) D		OCYMENE SYNTHASE (OS)	Erythranthe cardinalis (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, Deletion N	Erythranthe verbenacea (species) D	Interspecific	Candidate Gene	Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001762	TPS02 P0CJ43	Physiology	large deletion from the third exon to the last exon N	Erythranthe lewisii (species)	Erythranthe verbenacea (species) D		OCYMENE SYNTHASE (OS)	Erythranthe verbenacea (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, Insertion N	Erythranthe bicolor (species) D	Interspecific	Candidate Gene	Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001763	TPS02 P0CJ43	Physiology	2-bp insertion in the second exon, producing a frameshift mutation and premature termination N	Erythranthe lewisii (species)	Erythranthe bicolor (species) D		OCYMENE SYNTHASE (OS)	Erythranthe bicolor (species)	Published - Accepted by Curator
Odorant receptor 3 (OR3)	Olfactory behavior (pheromone)	Coding, SNP	Ostrinia furnacalis Asian corn borer - (species)	Interspecific	Candidate Gene	Leary GP; Allen JE; Bunger PL ; et al. (2012) Single mutation to a sex pheromone receptor provides adaptive specificity between closely related mo[...]	GP00000749	OR3 D3J5H6	Behavior	A148T	Ostrinia nubilalis European corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species)		Odorant receptor 3 (OR3)	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]	Fragrance	Cis-regulatory, Unknown	Petunia exserta (species)	Interspecific	Linkage Mapping	Klahre U; Gurba A; Hermann K ; et al. (2011) Pollinator choice in Petunia depends on two major genetic Loci for floral scent production.	GP00000750	ODO1 Q50EX6	Physiology	Not identified; but probably homologous to P. hybrida Mitchell x R27 promoter variation since these P. hybrida accessions are derived from a P. axillaris x P. integrifolia cross	Petunia axillaris (species)	Petunia exserta (species)		ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]	Petunia exserta (species)	Published - Accepted by Curator
Odysseus-site homeobox	Hybrid incompatibility (F1 male sterility)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Bayes JJ; Malik HS (2009) Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species.	GP00000752	OdsH Q9VX20	Physiology	Rapid coding divergence	Drosophila mauritiana (species)	Drosophila simulans (species)		Odysseus-site homeobox	Drosophila simulans (species)	Published - Accepted by Curator
opsin	Color vision (blue)	Coding, SNP	Alloteuthis subulata (species)	Interspecific	Candidate Gene	Morris A; Bowmaker JK; Hunt DM (1993) The molecular basis of a spectral shift in the rhodopsins of two species of squid from different pho[...]	GP00000755	opn1sw1 Q9W6A9	Physiology	F270S	Loligo forbesii northern European squid - (species)	Alloteuthis subulata (species)		opsin	Alloteuthis subulata (species)	Published - Accepted by Curator
opsin - (SWS2B)	Color vision	Coding, SNP	Tramitichromis intermedius (species)	Interspecific	Candidate Gene	O'Quin KE; Schulte JE; Patel Z ; et al. (2012) Evolution of cichlid vision via trans-regulatory divergence.	GP00001440	opn1sw2 Q9W6A8	Physiology	Ala269Thr causing a 10nm Spectral Sensitivity Shift	Aulonocara baenschi Nkhomo-benga peacock cichlid - (species)	Tramitichromis intermedius (species)		opsin - (SWS2B)	Tramitichromis intermedius (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	Coding, SNP	Neochromis greenwoodi (species)	Interspecific	Candidate Gene	Terai Y; Seehausen O; Sasaki T ; et al. (2006) Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids.	GP00000776	OPN1LW P04000	Physiology	Candidate mutations are CS180A and/or I277C (human LWS/MWS numbering)	African cichlids (no rank)	Neochromis greenwoodi (species)		opsin - rhodopsin (LWS)	Neochromis greenwoodi (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002353	OPN1LW P04000	Physiology	Lws2 coding sequence absent from the full genome sequence N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D		opsin - rhodopsin (LWS)	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
Or22a	Olfaction	Coding, SNP	Drosophila sechellia (species) D Drosophila simulans (species) D Drosophila mauritiana (species) D	Interspecific	Candidate Gene	Auer TO; Khallaf MA; Silbering AF ; et al. (2020) Olfactory receptor and circuit evolution promote host specialization.	GP00002183	Or22a P81909	Physiology	Effect of the mutation tested in a Or22a construct which rescues the Or22a knock-down mutation in D. melanogaster.There are two other amino acid changes that may have an effect as well.	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D Drosophila simulans (species) D Drosophila mauritiana (species) D		Or22a	Drosophila sechellia (species) Drosophila simulans (species) Drosophila mauritiana (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000803	OR7D4 Q8NG98	Physiology	R227G	Homininae (subfamily)	Homo sapiens human - (species) D		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000804	OR7D4 Q8NG98	Physiology	M273T	Homininae (subfamily)	Homo sapiens human - (species) D		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
Patched1 (Ptc1)	Cranio-facial morphology	Cis-regulatory, Unknown	Maylandia mbenjii (species) D	Interspecific	Linkage Mapping	Roberts RB; Hu Y; Albertson RC ; et al. (2011) Craniofacial divergence and ongoing adaptation via the hedgehog pathway. 1 Additional References Hu Y; Albertson RC (2014) Hedgehog signaling mediates adaptive variation in a dynamic functional system in the cichlid feeding[...]	GP00000856	ptch1 Q98864	Morphology	Uncharacterized cis-regulatory change - with ancestral Labeotropheus (LF) allele exhibiting relatively higher levels of expression	Labeotropheus fuelleborni blue mbuna - (species)	Maylandia mbenjii (species) D		Patched1 (Ptc1)	Maylandia mbenjii (species)	Published - Accepted by Curator
pax3a	Coloration (scales)	Cis-regulatory, SNP	Tropheops sp. 'red cheek' (species)	Interspecific	Linkage Mapping	Albertson RC; Powder KE; Hu Y ; et al. (2014) Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichl[...]	GP00001417	pax3a Q6DHA7	Morphology	C>T SNP within 5UTR	Labeotropheus fuelleborni blue mbuna - (species)	Tropheops sp. 'red cheek' (species)		pax3a	Tropheops sp. 'red cheek' (species)	Published - Accepted by Curator
pax3b	Coloration (scales)	Unknown, Unknown	Tropheops sp. 'red cheek' (species)	Interspecific	Linkage Mapping	Albertson RC; Powder KE; Hu Y ; et al. (2014) Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichl[...]	GP00001419	pax3-b Q0IH87	Morphology	unknown	Labeotropheus fuelleborni blue mbuna - (species)	Tropheops sp. 'red cheek' (species)		pax3b	Tropheops sp. 'red cheek' (species)	Published - Accepted by Curator
Pax7	Coloration (scales)	Cis-regulatory, Unknown	Maylandia zebra zebra mbuna - (species)	Interspecific	Linkage Mapping	Roberts RB; Ser JR; Kocher TD (2009) Sexual conflict resolved by invasion of a novel sex determiner in Lake Malawi cichlid fishes.	GP00000857	Pax7 P47239	Morphology	Not identified	Labeotropheus fuelleborni blue mbuna - (species)	Maylandia zebra zebra mbuna - (species)		Pax7	Maylandia zebra zebra mbuna - (species)	Published - Accepted by Curator
pdm3	Coloration (abdomen; male)	Cis-regulatory, Unknown	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Liu Y; Ramos-Womack M; Han C ; et al. (2019) Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.	GP00002022	pdm3 A0A0B4LEG2	Morphology	change in a cis-regulatory region - exact causing mutation(s) unknown - increased pdm3 abdominal expression associated with lighter color	Drosophila yakuba (species)	Drosophila santomea (species) D		pdm3	Drosophila santomea (species)	Published - Accepted by Curator
Period (per)	Courtship song	Coding, SNP	Drosophila simulans (species)	Interspecific	Linkage Mapping	Wheeler DA; Kyriacou CP; Greenacre ML ; et al. (1991) Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaste[...] 3 Additional References Kyriacou CP; Hall JC (1986) Interspecific genetic control of courtship song production and reception in Drosophila. Kyriacou CP; Green EW; Piffer A (2017) Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detec[...] Stern DL (2014) Reported Drosophila courtship song rhythms are artifacts of data analysis.	GP00000860	per P07663	Behavior	A121T and/or K125R and/or E165D and /or V224A	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Period (per)	Drosophila simulans (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	Coding, SNP	Alloteropsis (genus)	Interspecific	Candidate Gene	Christin PA; Edwards EJ; Besnard G ; et al. (2012) Adaptive evolution of C(4) photosynthesis through recurrent lateral gene transfer.	GP00000866	PPCA P30694	Physiology	Haplotype of several candidate a.a. ; lateral gene transfer between convergent C4 species	Alloteropsis (genus)	Alloteropsis (genus)		phosphoenolpyruvate carboxylase (PEPC)	Alloteropsis (genus)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	2 Mutations: Coding SNP N	Flaveria trinervia (species)	Interspecific	Candidate Gene	Bläsing OE; Westhoff P; Svensson P (2000) Evolution of C4 phosphoenolpyruvate carboxylase in Flaveria, a conserved serine residue in the carbo[...] 1 Additional References Engelmann S; Bläsing OE; Gowik U (2003) Molecular evolution of C4 phosphoenolpyruvate carboxylase in the genus Flaveria--a gradual increase [...]	GP00000867	PPCA P30694	Physiology	2 mutations	Flaveria pringlei (species)	Flaveria trinervia (species)		phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	Cis-regulatory, Insertion	Flaveria trinervia (species) D	Interspecific	Candidate Gene	Akyildiz M; Gowik U; Engelmann S ; et al. (2007) Evolution and function of a cis-regulatory module for mesophyll-specific gene expression in the C4 d[...]	GP00000868	PPCA P30694	Physiology	insertion of tetranucleotide CACT	Flaveria pringlei (species)	Flaveria trinervia (species) D		phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	Cis-regulatory, SNP	Flaveria trinervia (species)	Interspecific	Candidate Gene	Akyildiz M; Gowik U; Engelmann S ; et al. (2007) Evolution and function of a cis-regulatory module for mesophyll-specific gene expression in the C4 d[...]	GP00000869	PPCA P30694	Physiology	G->A	Flaveria pringlei (species)	Flaveria trinervia (species)		phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
prodynorphin (PDYN)	Neuroendocronological homeostasis	Cis-regulatory, SNP	Homo sapiens human - (species)	Interspecific	Candidate Gene	Rockman MV; Hahn MW; Soranzo N ; et al. (2005) Ancient and recent positive selection transformed opioid cis-regulation in humans. 1 Additional References Babbitt CC; Silverman JS; Haygood R (2010) Multiple Functional Variants in cis Modulate PDYN Expression.	GP00000924	PDYN P01213	Physiology	up to 5 polymorphisms in 5' regulatory region	Primates (order)	Homo sapiens human - (species)		prodynorphin (PDYN)	Homo sapiens human - (species)	Published - Accepted by Curator
prophenoloxidase 3 (PPO3)	Immune response (melanotic encapsulation by lamellocytes)	Coding, SNP N	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Dudzic JP; Kondo S; Ueda R ; et al. (2015) Drosophila innate immunity: regional and functional specialization of prophenoloxidases.	GP00001781	PPO3 Q9W1V6	Physiology	amino acid change at position 48 which converts the terminal glutamine residue of the propeptide region to a stop codon, and is predicted to generate a truncated version of the PPO3 protein N	Drosophila simulans (species) Drosophila mauritiana (species)	Drosophila sechellia (species) D		prophenoloxidase 3 (PPO3)	Drosophila sechellia (species)	Published - Accepted by Curator
PTS/TKD1	Leaf shape	Cis-regulatory, Deletion	Solanum galapagense (species) D	Interspecific	Linkage Mapping	Kimura S; Koenig D; Kang J ; et al. (2008) Natural variation in leaf morphology results from mutation of a novel KNOX gene.	GP00000938	PTS B2Y2G9	Morphology	1bp deletion at -1232 from start Met	Solanum cheesmaniae (species)	Solanum galapagense (species) D		PTS/TKD1	Solanum galapagense (species)	Published - Accepted by Curator
qSH1 (REPLUMLESS)	Seed shattering	Cis-regulatory, SNP	Brassicaceae mustard family - (family)	Interspecific	Candidate Gene	Arnaud N; Lawrenson T; Østergaard L ; et al. (2011) The same regulatory point mutation changed seed-dispersal structures in evolution and domestication.	GP00000943	qSH1 Q941S9	Physiology	1bp change	Brassicaceae mustard family - (family)	Brassicaceae mustard family - (family)		qSH1 (REPLUMLESS)	Brassicaceae mustard family - (family)	Published - Accepted by Curator
RCO-A	Leaf shape (simplification)	Cis-regulatory, Unknown	Capsella grandiflora (species)	Interspecific	Linkage Mapping	Sicard A; Thamm A; Marona C ; et al. (2014) Repeated evolutionary changes of leaf morphology caused by mutations to a homeobox gene.	GP00000961	RCO A0A023NDU4	Morphology	Complex haplotype	Capsella rubella (species)	Capsella grandiflora (species)		RCO-A	Capsella grandiflora (species)	Published - Accepted by Curator
RCO-A/B (Reduced Complexity)	Leaf shape (simplification)	Gene Loss, Deletion N	Arabidopsis thaliana thale cress - (species) D	Interspecific	Candidate Gene	Vlad D; Kierzkowski D; Rast MI ; et al. (2014) Leaf shape evolution through duplication, regulatory diversification, and loss of a homeobox gene.	GP00000962	RCO A0A023NDU4	Morphology	Gene deletion N	Arabidopsis (genus)	Arabidopsis thaliana thale cress - (species) D		RCO-A/B (Reduced Complexity)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RNASE1B	Folivory (digestion of bacteria at low pH)	Coding, SNP	Presbytis melalophos mitred leaf monkey - (species) D	Interspecific	Candidate Gene	Zhou X; Wang B; Pan Q ; et al. (2014) Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]	GP00001414	RNASE1B Q8SPN3	Physiology	p.Arg39Gln	Colobinae (subfamily)	Presbytis melalophos mitred leaf monkey - (species) D		RNASE1B	Presbytis melalophos mitred leaf monkey - (species)	Published - Accepted by Curator
RNASE4	High-altitude adaptation (enhanced angiogenesis)	2 Mutations: Coding SNP	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001505	RNASE4 P34096	Physiology	2 mutations	Rhinopithecus avunculus Tonkin snub-nosed monkey - (species)	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D		RNASE4	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) Rhinopithecus bieti black snub-nosed monkey - (species)	Published - Accepted by Curator
RNASE4 [likely pseudo-replicate of other RNASE4 entry by introgression]	High-altitude adaptation (enhanced angiogenesis)	2 Mutations: Coding SNP	Rhinopithecus roxellana golden snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001506	RNASE4 P34096	Physiology	2 mutations	Rhinopithecus brelichi Gray snub-nosed monkey - (species)	Rhinopithecus roxellana golden snub-nosed monkey - (species) D		RNASE4 [likely pseudo-replicate of other RNASE4 entry by introgression]	Rhinopithecus roxellana golden snub-nosed monkey - (species)	Published - Accepted by Curator
ROSE INTENSITY1 (ROI1)	Coloration (flowers)	Cis-regulatory, Unknown	Erythranthe lewisii (species)	Interspecific	Linkage Mapping	Yuan YW; Sagawa JM; Young RC ; et al. (2013) Genetic dissection of a major anthocyanin QTL contributing to pollinator-mediated reproductive isola[...]	GP00000996	ROI1 L7VK04	Morphology	unknown but coding variation was ruled out	Erythranthe lewisii (species)	Erythranthe lewisii (species)		ROSE INTENSITY1 (ROI1)	Erythranthe lewisii (species)	Published - Accepted by Curator
RPP13	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Interspecific	Linkage Mapping	Rose LE; Bittner-Eddy PD; Langley CH ; et al. (2004) The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsi[...]	GP00001005	RPP13 Q9M667	Physiology	Various haplotypes	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP13	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Rx1	Color vision (expression of SWS2b opsin)	Cis-regulatory, Indel	Tramitichromis intermedius (species)	Interspecific	Linkage Mapping	Schulte JE; O'Brien CS; Conte MA ; et al. (2014) Interspecific variation in Rx1 expression controls opsin expression and causes visual system diversi[...]	GP00001441	rx1 O42356	Physiology	413bp deletion located 2.5-kb upstream of the Rx1 translation start site correlating with decreased Rx1 expression	Aulonocara baenschi Nkhomo-benga peacock cichlid - (species)	Tramitichromis intermedius (species)		Rx1	Tramitichromis intermedius (species)	Published - Accepted by Curator
SAP (Sterile Apetala)	Petal size	Cis-regulatory, SNP	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sicard A; Kappel C; Lee YW ; et al. (2016) Standing genetic variation in a tissue-specific enhancer underlies selfing-syndrome evolution in Cap[...]	GP00001371	SAP Q9FKH1	Morphology	5 SNP in intron in particular	Capsella grandiflora (species)	Capsella rubella (species) D		SAP (Sterile Apetala)	Capsella rubella (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000724	SCN4A P35499	Physiology	G1569D in DIV domain and D1568S in DIV domain with D1568S supposed to increase the resistance - exact causing mutation(s) unknown	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D		SCN4A (Nav1.4)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Rhabdophis tigrinus Tiger keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000725	SCN4A P35499	Physiology	I1555M	Thamnophis elegans Western terrestrial garter snake - (species)	Rhabdophis tigrinus Tiger keelback - (species) D		SCN4A (Nav1.4)	Rhabdophis tigrinus Tiger keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000726	SCN4A P35499	Physiology	D1277E in DIII domain	Thamnophis couchii (species)	Thamnophis atratus (species) D		SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000727	SCN4A P35499	Physiology	D1568N in DIV domain	Thamnophis couchii (species)	Thamnophis atratus (species) D		SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis couchii (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000728	SCN4A P35499	Physiology	M1276T in DIII domain	Thamnophis atratus (species)	Thamnophis couchii (species) D		SCN4A (Nav1.4)	Thamnophis couchii (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Hebius pryeri Pryer's keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000729	SCN4A P35499	Physiology	D1227E = D945E in DIII domain	Hebius vibakari Japanese keelback - (species)	Hebius pryeri Pryer's keelback - (species) D		SCN4A (Nav1.4)	Hebius pryeri Pryer's keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000722	SCN4A P35499	Physiology	Y401N	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)		SCN4A (Nav1.4a gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000723	SCN4A P35499	Physiology	Y401C	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)		SCN4A (Nav1.4a gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes. 1 Additional References Jost MC; Hillis DM; Lu Y (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000733	SCN4A P35499	Physiology	E945D	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)		SCN4A (Nav1.4b gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Jost MC; Hillis DM; Lu Y ; et al. (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000734	SCN4A P35499	Physiology	M1240T	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)		SCN4A (Nav1.4b gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Micrurus fulvius eastern coral snake - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001653	SCN8A A0A1B0Z7H0	Physiology	I1709V in DIV domain (2x resistance)	Naja kaouthia monocled cobra - (species)	Micrurus fulvius eastern coral snake - (species) D		SCN8A (Nav1.6)	Micrurus fulvius eastern coral snake - (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Elapsoidea nigra (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001654	SCN8A A0A1B0Z7G3	Physiology	I1709V in DIV domain (2x resistance)	Naja kaouthia monocled cobra - (species)	Elapsoidea nigra (species) D		SCN8A (Nav1.6)	Elapsoidea nigra (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001655	SCN8A A0A1B0Z7B3	Physiology	G1717M in DIV domain (not tested)	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D		SCN8A (Nav1.6)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Lygophis anomalus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001656	SCN8A A0A1B0Z7F2	Physiology	V1709I (reversion) in DIV domain (loss of resistance)	Helicops angulatus (species)	Lygophis anomalus (species) D		SCN8A (Nav1.6)	Lygophis anomalus (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Anilios bituberculatus prong-snouted blind snake - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001643	SCN9A Q15858	Physiology	M1392A in DIII domain (not tested)	Anolis carolinensis green anole - (species)	Anilios bituberculatus prong-snouted blind snake - (species) D		SCN9A (Nav1.7)	Anilios bituberculatus prong-snouted blind snake - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Chrysemys picta painted turtle - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001647	SCN9A Q15858	Physiology	A1681G in DIV domain (1.5x resistance)	Gallus gallus chicken - (species)	Chrysemys picta painted turtle - (species) D		SCN9A (Nav1.7)	Chrysemys picta painted turtle - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Anolis carolinensis green anole - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001649	SCN9A Q15858	Physiology	D1684A (most probably N>A) in DIV domain (150x resistance)	Dopasia gracilis Burmese glass lizard - (species)	Anolis carolinensis green anole - (species) D		SCN9A (Nav1.7)	Anolis carolinensis green anole - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Epicrates cenchria (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001650	SCN9A Q15858	Physiology	D1684H (most probably N>H) in DIV domain (not tested)	Boa constrictor boa - (species)	Epicrates cenchria (species) D		SCN9A (Nav1.7)	Epicrates cenchria (species)	Published - Accepted by Curator
Sdic gene cluster	Fertility (sperm competition; sperm competence)	Gene Amplification, Complex Change	Drosophila melanogaster fruit fly - (species)	Interspecific	Candidate Gene	Nurminsky DI; Nurminskaya MV; De Aguiar D ; et al. (1998) Selective sweep of a newly evolved sperm-specific gene in Drosophila. 1 Additional References Nurminsky DI; Nurminskaya MV; De Aguiar D (1998) Selective sweep of a newly evolved sperm-specific gene in Drosophila.	GP00001032	Sdic1 Q9W5W4	Physiology	Gene duplication	melanogaster subgroup (species subgroup)	Drosophila melanogaster fruit fly - (species)		Sdic gene cluster	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
sdY	Sex determination	Unknown, Unknown	Teleostei teleost fishes - (infraclass)	Interspecific	Linkage Mapping	Yano A; Guyomard R; Nicol B ; et al. (2012) An immune-related gene evolved into the master sex-determining gene in rainbow trout, Oncorhynchus m[...]	GP00001033	sdy I7GVT3	Physiology	Novel gene evolution by modification of the irf9 gene; unrelated to sex determination	Oncorhynchus mykiss rainbow trout - (species)	Teleostei teleost fishes - (infraclass)		sdY	Teleostei teleost fishes - (infraclass)	Published - Accepted by Curator
sid-2	Immune response (RNAi efficiency)	Unknown, Unknown	Caenorhabditis elegans (species)	Interspecific	Candidate Gene	Winston WM; Sutherlin M; Wright AJ ; et al. (2007) Caenorhabditis elegans SID-2 is required for environmental RNA interference.	GP00001051	sid-2 G5EEV9	Physiology	unknown	Caenorhabditis (genus)	Caenorhabditis elegans (species)		sid-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
SIGLEC13	Pathogen resistance	Gene Loss, Complex Change N	Homo sapiens human - (species)	Interspecific	Candidate Gene	Wang X; Mitra N; Secundino I ; et al. (2012) Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.	GP00001052	SIGLEC13 Q64JA4	Physiology	Gene deletion by Alu-mediated recombination N	Primates (order)	Homo sapiens human - (species)		SIGLEC13	Homo sapiens human - (species)	Published - Accepted by Curator
SIGLEC17P (pseudogene)	Pathogen resistance	Coding, Deletion N	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Wang X; Mitra N; Secundino I ; et al. (2012) Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.	GP00001053	SIGLEC13 Q64JA4	Physiology	1bp deletion resulting in frame-shift (pseudogenization) N	Primates (order)	Homo sapiens human - (species) D		SIGLEC17P (pseudogene)	Homo sapiens human - (species)	Published - Accepted by Curator
Svb/ovo	Trichome pattern (larva)	9 Mutations: Cis-regulatory	Drosophila sechellia (species) D	Interspecific	Linkage Mapping	McGregor AP; Orgogozo V; Delon I ; et al. (2007) Morphological evolution through multiple cis-regulatory mutations at a single gene. 1 Additional References Preger-Ben Noon E; Davis FP; Stern DL (2016) Evolved Repression Overcomes Enhancer Robustness.	GP00001085	ovo P51521	Morphology	9 mutations	Drosophila simulans (species) Drosophila mauritiana (species)	Drosophila sechellia (species) D		Svb/ovo	Drosophila sechellia (species)	Published - Accepted by Curator
Svb/ovo	Trichome pattern (larva)	Cis-regulatory, Unknown	Drosophila ezoana (species)	Interspecific	Candidate Gene	Frankel N; Wang S; Stern DL (2012) Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolu[...] 1 Additional References Sucena E; Delon I; Jones I (2003) Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelism.	GP00001086	ovo P51521	Morphology	unknown	virilis group (species group)	Drosophila ezoana (species)		Svb/ovo	Drosophila ezoana (species)	Published - Accepted by Curator
tan	Coloration (abdomen; male)	2 Mutations: Cis-regulatory SNP	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Jeong S; Rebeiz M; Andolfatto P ; et al. (2008) The evolution of gene regulation underlies a morphological difference between two Drosophila sister [...] 1 Additional References Rebeiz M; Ramos-Womack M; Jeong S (2009) Evolution of the tan locus contributed to pigment loss in Drosophila santomea: a response to Matute [...]	GP00001099	t Q9W369	Morphology	2 mutations	Drosophila yakuba (species)	Drosophila santomea (species) D		tan	Drosophila santomea (species)	Published - Accepted by Curator
tan	Coloration (abdomen; male)	Cis-regulatory, Deletion	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Jeong S; Rebeiz M; Andolfatto P ; et al. (2008) The evolution of gene regulation underlies a morphological difference between two Drosophila sister [...] 1 Additional References Rebeiz M; Ramos-Womack M; Jeong S (2009) Evolution of the tan locus contributed to pigment loss in Drosophila santomea: a response to Matute [...]	GP00001100	t Q9W369	Morphology	san MSE del30 (30bp deletion)	Drosophila yakuba (species)	Drosophila santomea (species) D		tan	Drosophila santomea (species)	Published - Accepted by Curator
tan	Coloration (abdomen; male)	Cis-regulatory, Deletion	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Jeong S; Rebeiz M; Andolfatto P ; et al. (2008) The evolution of gene regulation underlies a morphological difference between two Drosophila sister [...] 1 Additional References Rebeiz M; Ramos-Womack M; Jeong S (2009) Evolution of the tan locus contributed to pigment loss in Drosophila santomea: a response to Matute [...]	GP00001101	t Q9W369	Morphology	san MSE del212 (212bp deletion)	Drosophila yakuba (species)	Drosophila santomea (species) D		tan	Drosophila santomea (species)	Published - Accepted by Curator
tartan	Organ size (genitalia; clasper) Bristle number (genitalia; clasper)	Cis-regulatory, Unknown	Drosophila mauritiana (species) D	Interspecific	Linkage Mapping	Hagen JFD; Mendes CC; Blogg A ; et al. (2019) tartan underlies the evolution of Drosophila male genital morphology.	GP00002047	trn Q9VU51	Morphology Morphology	no coding changes	Drosophila simulans (species)	Drosophila mauritiana (species) D		tartan	Drosophila mauritiana (species)	Published - Accepted by Curator
TAS1R1	Taste sensitivity (sugar)	Coding, Unknown	Calypte anna Anna's hummingbird - (species) D	Interspecific	Candidate Gene	Baldwin MW; Toda Y; Nakagita T ; et al. (2014) Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancest[...]	GP00001307	T1R1 A0A088DBT6	Physiology	unknown	Gallus gallus chicken - (species)	Calypte anna Anna's hummingbird - (species) D		TAS1R1	Calypte anna Anna's hummingbird - (species)	Published - Accepted by Curator
TAS1R1	Taste sensitivity (umami)	Coding, Deletion N	Ailurus fulgens lesser panda - (species) D	Interspecific	Candidate Gene	Hu Y; Wu Q; Ma S ; et al. (2017) Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas.	GP00001415	Tas1r1 Q99PG6	Physiology	1bp deletion (deletion of a C) in the sixth exon; N	Ursus maritimus polar bear - (species)	Ailurus fulgens lesser panda - (species) D		TAS1R1	Ailurus fulgens lesser panda - (species)	Published - Accepted by Curator
TAS1R1	Taste sensitivity (umami)	Coding, Deletion N	Ailuropoda melanoleuca giant panda - (species) D	Interspecific	Candidate Gene	Li R; Fan W; Tian G ; et al. (2010) The sequence and de novo assembly of the giant panda genome. 2 Additional References Hu Y; Wu Q; Ma S (2017) Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas. Zhao H; Yang JR; Xu H (2010) Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dieta[...]	GP00001416	Tas1r1 Q99PG6	Physiology	pseudogene due to three indel mutations in the third and sixth exons. The giant panda has one 2-bp insertion on the third exon and two deletions (6-bp and 4-bp) on the sixth exon, N	Ursus maritimus polar bear - (species)	Ailuropoda melanoleuca giant panda - (species) D		TAS1R1	Ailuropoda melanoleuca giant panda - (species)	Published - Accepted by Curator
TAS1R3	Taste sensitivity (sugar)	Coding, SNP	Calypte anna Anna's hummingbird - (species) D	Interspecific	Candidate Gene	Baldwin MW; Toda Y; Nakagita T ; et al. (2014) Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancest[...]	GP00001306	T1R3 A0A088DCH0	Physiology	19 nonconsecutive amino acids confer sugar responsiveness and they are confined to three different regions of the protein - change(s) in all 3 regions are required for the acquisition of sugar binding- The exact effect of each single amino acid change has not been tested	Gallus gallus chicken - (species)	Calypte anna Anna's hummingbird - (species) D		TAS1R3	Calypte anna Anna's hummingbird - (species)	Published - Accepted by Curator
Thermo-tolerance 1 (TT1)	Temperature tolerance	Coding, SNP	Oryza glaberrima African rice - (species) D	Interspecific	Linkage Mapping	Li XM; Chao DY; Wu Y ; et al. (2015) Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of Afri[...]	GP00001566	PAB1 Q10KF0	Physiology	p.R99H	Oryza sativa rice - (species)	Oryza glaberrima African rice - (species) D		Thermo-tolerance 1 (TT1)	Oryza glaberrima African rice - (species)	Published - Accepted by Curator
touch insensitive larva B (tilB)	Pupation site choice	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Pischedda A; Shahandeh MP; Turner TL (2020) The Loci of Behavioral Evolution: Evidence That Fas2 and tilB Underlie Differences in Pupation Site [...]	GP00002344	tilB Q9VR52	Behavior	Gene identified via deficiency mapping. Gene more highly expressed in D. melanogaster than in D. simulans. RNAi in D. melanogaster leads to pupae pupating closer to the food.	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		touch insensitive larva B (tilB)	Drosophila simulans (species)	Published - Accepted by Curator
tra-2	Fertility (self-fertility; hermaphrodite spermatogenesis)	Cis-regulatory, Insertion	Caenorhabditis elegans (species)	Interspecific	Candidate Gene	Kuwabara PE (1996) Interspecies comparison reveals evolution of control regions in the nematode sex-determining gene tr[...] 2 Additional References Haag ES; Kimble J (2000) Regulatory elements required for development of caenorhabditis elegans hermaphrodites are conserved [...] Beadell AV; Liu Q; Johnson DM (2011) Independent recruitments of a translational regulator in the evolution of self-fertile nematodes.	GP00001132	tra-2 P34709	Physiology	Tandem duplication of GLD-1 binding sites in 3'UTR; see also fog-2 entry	Caenorhabditis briggsae (species)	Caenorhabditis elegans (species)		tra-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (albinism)	Coding, SNP N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002357	Tyr P11344	Morphology; Physiology	G420R amino acid change which is identical to one identified in Caucasian human patients (G419R) http://www.ifpcs.org/albinism/oca1mut.html N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		tyrosinase (TYR)	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
Ultrabithorax (Ubx)	Trichome pattern (leg)	Cis-regulatory, Unknown	Drosophila simulans (species)	Interspecific	Candidate Gene	Stern DL (1998) A role of Ultrabithorax in morphological differences between Drosophila species.	GP00001161	Ubx P83949	Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Ultrabithorax (Ubx)	Drosophila simulans (species)	Published - Accepted by Curator
Unpaired-like	Wing shape (sex-specific) Wing size	Cis-regulatory, Unknown	Nasonia giraulti (species)	Interspecific	Linkage Mapping	Loehlin DW; Werren JH (2012) Evolution of shape by multiple regulatory changes to a growth gene.	GP00001163	upd1 O96525	Morphology Morphology	three regions	Nasonia vitripennis jewel wasp - (species)	Nasonia giraulti (species)		Unpaired-like	Nasonia giraulti (species)	Published - Accepted by Curator
wingless (wg)	Coloration (wing)	3 Mutations: Cis-regulatory Unknown	Drosophila guttifera (species) D	Interspecific	Candidate Gene	Koshikawa S; Giorgianni MW; Vaccaro K ; et al. (2015) Gain of cis-regulatory activities underlies novel domains of wingless gene expression in Drosophila. 1 Additional References Werner T; Koshikawa S; Williams TM (2010) Generation of a novel wing colour pattern by the Wingless morphogen.	GP00001384	wg P09615	Morphology	3 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila guttifera (species) D		wingless (wg)	Drosophila guttifera (species)	Published - Accepted by Curator
Xmrk	Hybrid incompatibility (melanoma)	Unknown, Unknown	Xiphophorus hellerii green swordtail - (species)	Interspecific	Linkage Mapping	Adam D; Dimitrijevic N; Schartl M (1993) Tumor suppression in Xiphophorus by an accidentally acquired promoter. 1 Additional References Schartl M (2008) Evolution of Xmrk: an oncogene, but also a speciation gene?	GP00001219	xmrk P13388	Physiology	Various	Xiphophorus maculatus southern platyfish - (species)	Xiphophorus hellerii green swordtail - (species)		Xmrk	Xiphophorus hellerii green swordtail - (species)	Published - Accepted by Curator
Xmrk	Hybrid incompatibility (melanoma)	Gene Loss, Deletion N	Xiphophorus malinche highland swordtail - (species) D	Interspecific	Association Mapping	Powell DL; García-Olazábal M; Keegan M ; et al. (2020) Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.	GP00002137	xmrk P13388	Physiology	Loss of Xmrk in several Xiphophorus species N	Xiphophorus birchmanni sheepshead swordtail - (species)	Xiphophorus malinche highland swordtail - (species) D		Xmrk	Xiphophorus malinche highland swordtail - (species)	Published - Accepted by Curator
yellow	Coloration (abdomen)	Cis-regulatory, Unknown	Drosophila kikkawai (species)	Interspecific	Candidate Gene	Jeong S; Rokas A; Carroll SB (2006) Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila e[...]	GP00001220	y P09957	Morphology	indel and/or SNP located within a cis-regulatory element	Drosophila melanogaster fruit fly - (species)	Drosophila kikkawai (species)		yellow	Drosophila kikkawai (species)	Published - Accepted by Curator
yellow	Coloration (wing spot)	Cis-regulatory, SNP	Drosophila gunungcola (species)	Interspecific	Candidate Gene	Prud'homme B; Gompel N; Rokas A ; et al. (2006) Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene. 1 Additional References Yeh SD; Liou SR; True JR (2006) Genetics of divergence in male wing pigmentation and courtship behavior between Drosophila elegans a[...]	GP00001221	y P09957	Morphology	within a 740bp-element; at least two and no more than seven point mutations involved	Drosophila elegans (species)	Drosophila gunungcola (species)		yellow	Drosophila gunungcola (species)	Published - Accepted by Curator
yellow	Coloration (wing spot)	Cis-regulatory, Unknown	Drosophila biarmipes (species) D	Interspecific	Candidate Gene	Gompel N; Prud'homme B; Wittkopp PJ ; et al. (2005) Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila[...]	GP00001222	y P09957	Morphology	wing spot activator element; within a 196bp fragment; sequences required for activation in the spot are located within or overlap with bp 425-453	Drosophila (subgenus)	Drosophila biarmipes (species) D		yellow	Drosophila biarmipes (species)	Published - Accepted by Curator
yellow	Coloration (wing spot)	Cis-regulatory, Unknown	Drosophila biarmipes (species) D	Interspecific	Candidate Gene	Gompel N; Prud'homme B; Wittkopp PJ ; et al. (2005) Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila[...]	GP00001223	y P09957	Morphology	wing spot repressor element; within a 675-bp fragment;	Drosophila (subgenus)	Drosophila biarmipes (species) D		yellow	Drosophila biarmipes (species)	Published - Accepted by Curator
yellow	Coloration (wing spot)	Cis-regulatory, Unknown	Drosophila mimetica (species)	Interspecific	Candidate Gene	Prud'homme B; Gompel N; Rokas A ; et al. (2006) Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene.	GP00001224	y P09957	Morphology	within a 740bp-element	Drosophila (subgenus)	Drosophila mimetica (species)		yellow	Drosophila mimetica (species)	Published - Accepted by Curator
yellow	Coloration (wing spot)	Cis-regulatory, Unknown	Drosophila tristis (species)	Interspecific	Candidate Gene	Prud'homme B; Gompel N; Rokas A ; et al. (2006) Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene.	GP00001225	y P09957	Morphology	within a 927 bp-element	Drosophila (subgenus)	Drosophila tristis (species)		yellow	Drosophila tristis (species)	Published - Accepted by Curator
yellow	Coloration (male-specific)	Unknown, Unknown	Drosophila merina (species)	Interspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001550	y P09957	Morphology	unknown	Drosophila ercepeae (species)	Drosophila merina (species)		yellow	Drosophila merina (species)	Published - Accepted by Curator
yellow	Coloration (male-specific)	Unknown, Unknown	Drosophila bipectinata (species)	Interspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001551	y P09957	Morphology	unknown	Drosophila malerkotliana (species)	Drosophila bipectinata (species)		yellow	Drosophila bipectinata (species)	Published - Accepted by Curator
yellow	Coloration (abdomen; male)	Cis-regulatory, Unknown	Drosophila santomea (species) D	Interspecific	Linkage Mapping	Liu Y; Ramos-Womack M; Han C ; et al. (2019) Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.	GP00002023	y P09957	Morphology	change in a cis-regulatory region - exact causing mutation(s) unknown - decreased yellow abdominal expression associated with lighter color	Drosophila yakuba (species)	Drosophila santomea (species) D		yellow	Drosophila santomea (species)	Published - Accepted by Curator
zeb1a	Coloration (fish fins)	Cis-regulatory, SNP	Tropheops sp. 'red cheek' (species)	Interspecific	Linkage Mapping	Albertson RC; Powder KE; Hu Y ; et al. (2014) Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichl[...]	GP00001418	zeb1a F1QMZ5	Morphology	intronic SNP	Labeotropheus fuelleborni blue mbuna - (species)	Tropheops sp. 'red cheek' (species)		zeb1a	Tropheops sp. 'red cheek' (species)	Published - Accepted by Curator
Zygotic hybrid rescue	F1 lethality (female-limited)	Unknown, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Ferree PM; Barbash DA (2009) Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality i[...]	GP00001228		Physiology	Heterochromatin incompatibilitity	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Zygotic hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator