Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

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Your research retrieved 254 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
ABCB4	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Bariami V; Jones CM; Poupardin R ; et al. (2012) Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]	GP00002607	Abcb4 P21440	Physiology	ABCB4 gene amplified about 6–7 times	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	ABCB4	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Insertion	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Atsumi S; Miyamoto K; Yamamoto K ; et al. (2012) Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin[...]	GP00000011	ABCC2 A0A0E3ZDK3	Physiology	1a.a. insertion at codon 234 (Tyr)	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	ABCC2	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D	Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00000030	Ace P07140	Physiology	F331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D	Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...] 4 Additional References Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Carletto J; Martin T; Vanlerberghe-Masutti F (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii. Benting J; Nauen R (2004) Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates res[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)	Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...] 1 Additional References Assogba BS; Djogbénou LS; Milesi P (2015) An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, [...]	GP00001372	Ace P07140	Physiology	Strict tandem duplication of 203kb encompassing 12 genes ; ace1 heterogeneous gene duplication (susceptible G119 and resistant S119 copies)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species)	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001373	Ace P07140	Physiology	Strict tandem 3 times duplication of 203kb encompassing 12 genes with partial internal deletion of 97kb in the third copy - ace1 homogeneous gene duplications (all 3 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species)	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001374	Ace P07140	Physiology	Strict tandem 5 times duplication of 203kb encompassing 12 genes - ace1 homogeneous gene duplications (all 5 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Nieuwenhuyse P; Demaeght P (2011) Acaricide resistance and resistance mechanisms in Tetranychus urticae populations from rose greenhou[...]	GP00002013	Ace P07140	Physiology	A201S	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Nabeshima T; Kozaki T; Tomita T ; et al. (2003) An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of[...]	GP00002015	Ace P07140	Physiology	Ser431Phe (position 331 in mature Torpedo protein)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	Acetylcholinesterase (Ace-1)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Jiang X; Qu M; Denholm I ; et al. (2009) Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]	GP00002453	Ace P07140	Physiology	an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D	Acetylcholinesterase (Ace-1)	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Lee DW; Choi JY; Kim WT ; et al. (2007) Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.). 3 Additional References Yeh SC; Lin CL; Chang C (2014) Amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos [...] Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Zhang LJ; Jing YP; Li XH (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...]	GP00002454	Ace P07140	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002512	Ace P07140	Physiology	F331W	Bemisia tabaci (species)	Bemisia tabaci (species) D	Acetylcholinesterase (Ace-1)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002571	Ace P07140	Physiology	S119G	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Leeuwen T; Grispou M (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...]	GP00002572	Ace P07140	Physiology	G328A	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Khajehali J; Van Leeuwen T; Grispou M ; et al. (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002573	Ace P07140	Physiology	F331W	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002574	Ace P07140	Physiology	D128E	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Li F; Han Z (2004) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 3 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00002577	Ace P07140	Physiology	A201S	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)	Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Reyes M; Rault M ; et al. (2006) Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002580	Ace P07140	Physiology	F399V = F290V	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D	Acetylcholinesterase (Ace-1)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Hadjivassilis A ; et al. (2007) A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipi[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002581	Ace P07140	Physiology	F290V	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002587	Ace P07140	Physiology	S329(228)P	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Acetylcholinesterase (Ace-1)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002589	Ace P07140	Physiology	F330S	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002590	Ace P07140	Physiology	F331H	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus kanzawai (species) D	Intraspecific	Candidate Gene	Aiki Yasuhiko; Kozaki Toshinori; Mizuno Hiroshi ; et al. (2005 ) Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resist[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002591	Ace P07140	Physiology	F331W	Tetranychus kanzawai (species)	Tetranychus kanzawai (species) D	Acetylcholinesterase (Ace-1)	Tetranychus kanzawai (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002592	Ace P07140	Physiology	F331C	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Candidate Gene	Carvalho Renato; Yang Yihua; Field Linda M ; et al. (2012 ) Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002593	Ace P07140	Physiology	F331W/Y	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Zhang Yueliang; Li Shuo; Xu Lu ; et al. (2013 ) Overexpression of carboxylesterase-1 and mutation (F439H) of acetylcholinesterase-1 are associated w[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002594	Ace P07140	Physiology	F331H	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D	Acetylcholinesterase (Ace-1)	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002595	Ace P07140	Physiology	L336S	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D	Acetylcholinesterase (Ace-1)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Zhang LJ; Jing YP; Li XH ; et al. (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002598	Ace P07140	Physiology	A441G	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	4 Mutations: Coding SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. 2 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Menozzi P; Shi MA; Lougarre A (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002011	Ace P07140	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00002012	Ace P07140	Physiology	Ile199Thr (position 129 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002016	Ace P07140	Physiology	Gly368Ala (position 328 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes - GGC>GCC	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002565	Ace P07140	Physiology	Phe392Trp mutation located in the acyl pocket of the active site gorge and recently shown to confer OP insensitivity in Culex tritaeniorhynchus	Bemisia tabaci (species)	Bemisia tabaci (species) D	Acetylcholinesterase (Ace-2)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002568	Ace P07140	Physiology	E73G	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Li Fei; Han Zhaojun (2004 ) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002569	Ace P07140	Physiology	F78L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	Acetylcholinesterase (Ace-2)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002570	Ace P07140	Physiology	E81K	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Kozaki T; Shono T; Tomita T ; et al. (2001) Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002575	Ace P07140	Physiology	I129V	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002576	Ace P07140	Physiology	I129V	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Temeyer KB; Li AY; Lohmeyer KH ; et al. (2008) Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002578	Ace P07140	Physiology	G227A	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	Acetylcholinesterase (Ace-2)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002579	Ace P07140	Physiology	S238G	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace-2)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002582	Ace P07140	Physiology	F290Y	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]	GP00002583	Ace P07140	Physiology	F466Y	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D	Acetylcholinesterase (Ace-2)	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002585	Ace P07140	Physiology	F368(290)L	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002586	Ace P07140	Physiology	V435(356)A	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Ceratitis capitata Mediterranean fruit fly - (species) D	Intraspecific	Candidate Gene	Magaña C; Hernández-Crespo P; Brun-Barale A ; et al. (2008) Mechanisms of resistance to malathion in the medfly Ceratitis capitata. 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002588	Ace P07140	Physiology	Gly328Ala	Ceratitis capitata Mediterranean fruit fly - (species)	Ceratitis capitata Mediterranean fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Ceratitis capitata Mediterranean fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Nabeshima T; Mori A; Kozaki T ; et al. (2004) An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Ja[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002596	Ace P07140	Physiology	F331W - F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	Acetylcholinesterase (Ace-2)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002597	Ace P07140	Physiology	W435R	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D	Acetylcholinesterase (Ace-2)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, Deletion	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008) A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...] 1 Additional References Kakani EG; Bon S; Massoulié J (2011) Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides.	GP00000038	Ace P07140	Physiology	9bp deletion of three glutamine residues at positions 642_644	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Haymer DS; Wu WJ ; et al. (2006) Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]	GP00000045	Ace P07140	Physiology	2 mutations	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00002014	Ace P07140	Physiology	Ser>Gly (238 is the corresponding position in Torpedo)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	cadherin	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000164	BtR Q19KJ3	Physiology	24bp in-frame deletion	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
CHKov1	Pathogen resistance Xenobiotic resistance (insecticide)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Magwire MM; Bayer F; Webster CL ; et al. (2011) Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...] 1 Additional References Aminetzach YT; Macpherson JM; Petrov DA (2005) Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila.	GP00000182	CHKov1 Q961V7	Physiology Physiology	Insertion of a Doc TE element resulting in novel; seemingly functional short protein	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CHKov1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP392A16	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Papapostolou KM; Riga M; Samantsidis GR (2022) Over-expression in cis of the midgut P450 CYP392A16 contributes to abamectin resistance in Tetranych[...]	GP00002471	Ace P07140	Physiology	several non-synonymous SNP - exact causing amino acid change(s) unknown. Functional analysis of the putative promoter region from the resistant and susceptible parental strains revealed a higher reporter gene expression confirming the presence of cis-acting regulatory mechanisms.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	CYP392A16	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CYP6BG1	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Li X; Shan C; Li F ; et al. (2019) Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resista[...] 1 Additional References Mallott M; Hamm S; Troczka BJ (2019) A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]	GP00002064	CYP6BG1 A0A222NX20	Physiology	promoters tested in luciferase assays	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	CYP6BG1	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
CYP6D1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Gao J; Scott JG (2006) Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the hou[...]	GP00002118	CYP6D1 Q27698	Physiology	15 bp insertion which disrupts a putative mdGfi-1 binding site in the CYP6D1v1 promoter. mdGfi-1 is a negative regulator of transcription so this leads to increased expression of CYP6D1	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	CYP6D1	Musca domestica house fly - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	4 Mutations: Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chung H; Bogwitz MR; McCart C ; et al. (2007) Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]	GP00000207	Cyp6g1 Q9V674	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	cyp6g1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Schlenke TA; Begun DJ (2004) Strong selective sweep associated with a transposon insertion in Drosophila simulans.	GP00002019	Cyp6g1 Q9V674	Physiology	insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D	cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013) Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]	GP00002020	Cyp6g1 Q9V674	Physiology	insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D	cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Riveron JM; Irving H; Ndula M ; et al. (2013) Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...] 1 Additional References Mugenzi LMJ; Menze BD; Tchouakui M (2019) Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy ag[...]	GP00000208	CYP2C9 P11712	Physiology	Cis-regulatory variation in CYP6P9b gene	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9 cluster (CYP6P9a and CYP6P9b)	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP6P9; CYP6P4 cluster	Xenobiotic resistance (insecticide)	5 Mutations:	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Wondji CS; Irving H; Morgan J ; et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...] 2 Additional References Weedall GD; Mugenzi LMJ; Menze BD (2019) A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing i[...] Wondji CS; Hearn J; Irving H (2022) RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ h[...]	GP00000209	Q2YH43	Physiology	5 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9; CYP6P4 cluster	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP9J26	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Bariami V; Jones CM; Poupardin R ; et al. (2012) Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]	GP00002606	CYP9J Q8T4S7	Physiology	CYP9J26 gene amplified about 6–7 times	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	CYP9J26	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
CYP9M6	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Experimental Evolution	Candidate Gene	Kasai S; Komagata O; Itokawa K ; et al. (2014) Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insens[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002448	CYP9M6 X5ICI6	Physiology	CYP9M6 has the capability to metabolize permethrin and is over expressed in the resistant strain partially due to gene amplification. The average copy number of the CYP9M9 gene is 4.6-fold more than the standard strain based on qPCR.	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	CYP9M6	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
esterase A8 and B8	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Qiao CL; Marquine M; Pasteur N ; et al. (1998) A new esterase gene amplification involved in OP resistance in Culex pipiens mosquitoes from China.	GP00002641	B1 P16854	Physiology	coamplification of both esterase loci (Est-2 and Est-3)	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	esterase A8 and B8	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
esterase B1 + esterase A	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Rooker S; Guillemaud T; Bergé J ; et al. (1996) Coamplification of esterase A and B genes as a single unit in Culex pipiens mosquitoes.	GP00000291	B1 P16854	Physiology	Amplification of a region containing both genes	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	esterase B1 + esterase A	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase B1 = esterase beta1	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Mouchès C; Pasteur N; Bergé JB ; et al. (1986) Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mo[...] 3 Additional References Guillemaud T; Raymond M; Tsagkarakou A (1999) Quantitative variation and selection of esterase gene amplification in Culex pipiens. Mouches C; Pauplin Y; Agarwal M (1990) Characterization of amplification core and esterase B1 gene responsible for insecticide resistance i[...] Guillemaud T; Rooker S; Pasteur N (1996) Testing the unique amplification event and the worldwide migration hypothesis of insecticide resista[...]	GP00000292	B1 P16854	Physiology	Amplification of esterase B1 only	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	esterase B1 = esterase beta1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase E4	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Field LM; Devonshire AL; Forde BG (1988) Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results[...] 2 Additional References Field LM; Blackman RL; Tyler-Smith C (1999) Relationship between amount of esterase and gene copy number in insecticide-resistant Myzus persicae[...] Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00000293	P35501	Physiology	Whole gene amplification. Amplification of the E4 gene is closely linked to a chromosomal translocation (the autosomal 1-3 translocation event) and amplified genes are situated at a single heterozygous site on autosome 3 as a tandem array of head-to-tail amplicons.	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	esterase E4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
esterase FE4	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Blackman RL; Spence JM; Field LM ; et al. (1999 ) Variation in the chromosomal distribution of amplified esterase (FE4) genes in Greek field populatio[...] 2 Additional References Field LM; Blackman RL; Tyler-Smith C (1999) Relationship between amount of esterase and gene copy number in insecticide-resistant Myzus persicae[...] Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00002642	P35502	Physiology	Gene amplification	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	esterase FE4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Newcomb RD; Campbell PM; Ollis DL ; et al. (1997) A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]	GP00000294	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)	esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Jackson CJ; Liu JW; Carr PD ; et al. (2013) Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]	GP00000295	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)	esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species)	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000296	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species)	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000297	LcaE7 Q25252	Physiology	Trp251Ser	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000298	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. de Carvalho RA; Torres TT; de Azeredo-Espin AM (2006) A survey of mutations in the Cochliomyia hominivorax (Diptera: Calliphoridae) esterase E3 gene assoc[...]	GP00002584	alphaE7 A0A0G3Z837	Physiology	G137D	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D	esterase isozyme E3	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
esterase isozyme E7 = E3	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Claudianos C; Russell RJ; Oakeshott JG (1999) The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]	GP00000299	LcaE7 Q25252	Physiology	Gly137Asp	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	esterase isozyme E7 = E3	Musca domestica house fly - (species)	Published - Accepted by Curator
esterase type I	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Schizaphis graminum greenbug - (species) D	Intraspecific	Candidate Gene	Ono M; Swanson JJ; Field LM ; et al. (1999) Amplification and methylation of an esterase gene associated with insecticide-resistance in greenbug[...] 1 Additional References Vontas JG; Small GJ; Hemingway J (2000) Comparison of esterase gene amplification, gene expression and esterase activity in insecticide susc[...]	GP00002637	P35501	Physiology	The type I esterase is amplified 4- to 8-fold in resistant S. graminum and that the amplified sequences contain 5-methylcytosine at MspI/HpaII sites.	Schizaphis graminum greenbug - (species)	Schizaphis graminum greenbug - (species) D	esterase type I	Schizaphis graminum greenbug - (species)	Published - Accepted by Curator
FMO2	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Mallott M; Hamm S; Troczka BJ ; et al. (2019) A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]	GP00002065	FMO2 Q99518	Physiology	a putatative transposon (233bp) insertion in the HAW promoter sequence just 140 bp upstream of the start codon of PxFMO2 which was absent in the ROTH promoter, the boundaries of all copies of this element were found to be defined by 34 bp imperfect terminal inverted repeats, increase the expression of the gene PxFMO2 downstream	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	FMO2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Wang ZJ; Liang CR; Shang ZY ; et al. (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]	GP00002491	nAChRbeta1 P04755	Physiology	R81T	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	nAChR	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Wang ZJ; Liang CR; Shang ZY ; et al. (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]	GP00002492	nAChRbeta1 P04755	Physiology	K264E	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	nAChR	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Puinean AM; Andrews M ; et al. (2011) Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotin[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]	GP00002553	nAChRbeta1 P04755	Physiology	R81T in the loop D region of the nAChR β1 subunit of the resistant clone	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	nAChR	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao WX; Narai Y; Nakano A ; et al. (2014) Spinosad resistance of melon thrips, Thrips palmi, is conferred by G275E mutation in α6 subunit of n[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002555	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Thrips palmi (species)	Thrips palmi (species) D	nAChR	Thrips palmi (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Xu X; Ding Q; Wang X ; et al. (2022) V101I and R81T mutations in the nicotinic acetylcholine receptor β1 subunit are associated with neon[...]	GP00002612	nAChRbeta1 P04755	Physiology	V101I	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	nAChR	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...] 1 Additional References Grigoraki L; Cowlishaw R; Nolan T (2021) CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	2 mutations	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005) Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...] 1 Additional References Franck P; Siegwart M; Olivares J (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D	para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000839	para P35500	Physiology	L925I in species D	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000840	para P35500	Physiology	M918L - ATG>CTG	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000841	para P35500	Physiology	2 mutations	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	3 Mutations: Coding SNP	Pediculus humanus human louse - (species) D	Intraspecific	Candidate Gene	Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010) Determination of knockdown resistance allele frequencies in global human head louse populations usin[...] 3 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Lee Si Hyeock; Gao Jian-Rong; Yoon Kyong Sup (2003 ) Sodium channel mutations associated with knockdown resistance in the human head louse, Pediculus cap[...]	GP00000846	para P35500	Physiology	3 mutations	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Sonoda S; Igaki C; Tsumuki H (2008) Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000848	para P35500	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)	para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001689	para P35500	Physiology	L1014F; Haplotype H02	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001691	para P35500	Physiology	L1014S; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species)	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles vagus (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001692	para P35500	Physiology	L1014S	Anopheles vagus (species)	Anopheles vagus (species) D	para (kdr)	Anopheles vagus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001695	para P35500	Physiology	L1014S	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles paraliae (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001696	para P35500	Physiology	L1014S	Anopheles paraliae (species)	Anopheles paraliae (species)	para (kdr)	Anopheles paraliae (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001699	para P35500	Physiology	L1014F; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Cimex lectularius bed bug - (species) D	Intraspecific	Candidate Gene	Yoon KS; Kwon DH; Strycharz JP ; et al. (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] 4 Additional References Yoon KS; Kwon DH; Strycharz JP (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] Seong KM; Lee DY; Yoon KS (2010) Establishment of quantitative sequencing and filter contact vial bioassay for monitoring pyrethroid [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Durand R; Cannet A; Berdjane Z (2012) Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France.	GP00001859	para P35500	Physiology	2 mutations	Cimex lectularius bed bug - (species)	Cimex lectularius bed bug - (species) D	para (kdr)	Cimex lectularius bed bug - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	González-Cabrera J; Davies TG; Field LM ; et al. (2013) An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor. 1 Additional References Hubert J; Nesvorna M; Kamler M (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00001860	para P35500	Physiology	L925V	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001861	para P35500	Physiology	M918L - found in samples from China and Europe	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001862	para P35500	Physiology	2 mutations	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species)	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001863	para P35500	Physiology	M918L - ATG>TTG - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).	Hyalella azteca (species)	Hyalella azteca (species)	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001864	para P35500	Physiology	L925V	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 3 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...] Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] Fontaine S; Caddoux L; Brazier C (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...]	GP00001865	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 1 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...]	GP00001866	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 2 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...] Brengues C; Hawkes NJ; Chandre F (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...]	GP00002444	para P35500	Physiology	V1016G	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002445	para P35500	Physiology	F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	3 Mutations: Coding SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Plernsub S; Saingamsook J; Yanola J ; et al. (2016) Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002446	para P35500	Physiology	3 mutations	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Kasai S; Ng LC; Lam-Phua SG ; et al. (2011) First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus. 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002447	para P35500	Physiology	F1534C	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002469	para P35500	Physiology	L1014S	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D	para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002470	para P35500	Physiology	L1014F	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D	para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002486	para P35500	Physiology	2 mutations	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002487	para P35500	Physiology	2 mutations	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	para (kdr)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Haddi K; Tomé HVV; Du Y ; et al. (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...] 1 Additional References Fan Y; O'Grady P; Yoshimizu M (2020) Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes ae[...]	GP00002488	para P35500	Physiology	2 mutations	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Zhang L; Li T ; et al. (2012) Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following i[...]	GP00002489	para P35500	Physiology	3 nonsynonymous A(109)S L(982)F and W(1573)R) and 6 synonymous L(852) G(891) A(1241) D(1245) P(1249) and G(1733)) mutations were identified. The co-existence of all 9 mutations and their homozygousity were found to be important factors for high levels of resistance.	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Marshall Kate L; Moran Christopher; Chen Yizhou ; et al. (2012 ) Detection of kdr pyrethroid resistance in the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), u[...] 2 Additional References Wang ZJ; Liang CR; Shang ZY (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002490	para P35500	Physiology	L1014F	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Linkage Mapping	Nyoni BN; Gorman K; Mzilahowa T ; et al. (2011) Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation[...]	GP00002493	para P35500	Physiology	M918T - first report of the M918T mutation in the absence of L1014F in any arthropod species.	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D	para (kdr)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Liriomyza huidobrensis pea leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002494	para P35500	Physiology	2 mutations	Liriomyza huidobrensis pea leafminer - (species)	Liriomyza huidobrensis pea leafminer - (species) D	para (kdr)	Liriomyza huidobrensis pea leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Liriomyza sativae vegetable leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002495	para P35500	Physiology	L1014F	Liriomyza sativae vegetable leafminer - (species)	Liriomyza sativae vegetable leafminer - (species) D	para (kdr)	Liriomyza sativae vegetable leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002496	para P35500	Physiology	2 mutations	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002497	para P35500	Physiology	T929I	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Carletto J; Martin T; Vanlerberghe-Masutti F ; et al. (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii.	GP00002498	para P35500	Physiology	M918L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002499	para P35500	Physiology	M918L in species B	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002500	para P35500	Physiology	M918L in species C	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Wu M; Gotoh H; Waters T ; et al. (2014) Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002501	para P35500	Physiology	2 mutations	Thrips tabaci (species)	Thrips tabaci (species) D	para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Morgan JA; Corley SW; Jackson LA ; et al. (2009) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boop[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002502	para P35500	Physiology	L925I - Cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216 results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly Bemisia tabaci.	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao Wen Xue; Sonoda Shoji (2012 ) Resistance to cypermethrin in melon thrips, Thrips palmi (Thysanoptera: Thripidae), is conferred by [...]	GP00002503	para P35500	Physiology	T929I	Thrips palmi (species)	Thrips palmi (species) D	para (kdr)	Thrips palmi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002504	para P35500	Physiology	T929I	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitophilus zeamais maize weevil - (species) D	Intraspecific	Candidate Gene	Araújo RA; Williamson MS; Bass C ; et al. (2011) Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gat[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002505	para P35500	Physiology	T929I	Sitophilus zeamais maize weevil - (species)	Sitophilus zeamais maize weevil - (species) D	para (kdr)	Sitophilus zeamais maize weevil - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002506	para P35500	Physiology	T929V	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002507	para P35500	Physiology	T929C	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002508	para P35500	Physiology	T929I	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002509	para P35500	Physiology	L1014F	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Endersby NM; Viduka K; Baxter SW ; et al. (2011) Widespread pyrethroid resistance in Australian diamondback moth, Plutella xylostella (L.), is relate[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002510	para P35500	Physiology	F1020S	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002511	para P35500	Physiology	T929V	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002514	para P35500	Physiology	T929V	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002515	para P35500	Physiology	L1014F	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Jonsson NN; Cutullè C; Corley SW ; et al. (2010) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus microp[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00002516	para P35500	Physiology	G72V = G933V - G toT non-synonymous mutation at nucleotide position 214 that results in a glycine to valine substitution (G72V)	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002517	para P35500	Physiology	I951V = I936V	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Lepeophtheirus salmonis salmon louse - (species) D	Intraspecific	Candidate Gene	Fallang A; Denholm I; Horsberg TE ; et al. (2005) Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice Lepeophtheirus salm[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002518	para P35500	Physiology	Q945R in transmembrane segment IIS5	Lepeophtheirus salmonis salmon louse - (species)	Lepeophtheirus salmonis salmon louse - (species) D	para (kdr)	Lepeophtheirus salmonis salmon louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Brengues C; Hawkes NJ; Chandre F ; et al. (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002519	para P35500	Physiology	I104M = I1011M	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Saavedra-Rodriguez K; Urdaneta-Marquez L; Rajatileka S ; et al. (2007) A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin A[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002520	para P35500	Physiology	I1011V	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Enayati AA; Vatandoost H; Ladonni H ; et al. (2003) Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Ano[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Safi NHZ; Ahmadi AA; Nahzat S (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002521	para P35500	Physiology	L1014F - one point mutation difference involving a single A-T base change encoding a leucine to phenylalanine amino acid substitution in the pyrethroid-resistant strain.	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D	para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Safi NHZ; Ahmadi AA; Nahzat S ; et al. (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002522	para P35500	Physiology	L1014S	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D	para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles subpictus (species) D	Intraspecific	Candidate Gene	Karunaratne SHPP; Hawkes Nicola J; Perera MDB ; et al. (2007 ) Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populatio[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002523	para P35500	Physiology	L1014F - TTA>TTT	Anopheles subpictus (species)	Anopheles subpictus (species) D	para (kdr)	Anopheles subpictus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Liu H; Zhang L ; et al. (2005) Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002524	para P35500	Physiology	L1014F	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	D	Intraspecific	Candidate Gene	Rothwell JT; Morgan JA; James PJ ; et al. (2011) Mechanism of resistance to synthetic pyrethroids in buffalo flies in south-east Queensland. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002525	para P35500	Physiology	L1014F		D	para (kdr)		Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Brassicogethes aeneus (species)	Intraspecific	Candidate Gene	Nauen Ralf; Zimmer Christoph T; Andrews Melanie ; et al. (2012 ) Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F.[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002526	para P35500	Physiology	L1014F - found in individuals from Denmark and Sweden	Brassicogethes aeneus (species)	Brassicogethes aeneus (species)	para (kdr)	Brassicogethes aeneus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Foster SP; Paul VL; Slater R ; et al. (2014) A mutation (L1014F) in the voltage-gated sodium channel of the grain aphid, Sitobion avenae, is asso[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002527	para P35500	Physiology	L1014F	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D	para (kdr)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Cerchiari B; Giannini S ; et al. (2005) Use of the RFLP-PCR diagnostic test for characterizing MACE and kdr insecticide resistance in the pe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002528	para P35500	Physiology	F979S (housefly numbering) located inside the linker segment IIS5-6	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species)	Intraspecific	Candidate Gene	Stump AD; Atieli FK; Vulule JM ; et al. (2004) Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles ga[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002529	para P35500	Physiology	L1014S	Anopheles arabiensis (species)	Anopheles arabiensis (species)	para (kdr)	Anopheles arabiensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Dykes CL; Das MK ; et al. (2010) Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in [...]	GP00002530	para P35500	Physiology	L1014S	Anopheles culicifacies (species)	Anopheles culicifacies (species) D	para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Bali P; Hemingway J ; et al. (2009) PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato.	GP00002531	para P35500	Physiology	L1014F	Anopheles culicifacies (species)	Anopheles culicifacies (species) D	para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Lüleyap HU; Alptekin D; Kasap H ; et al. (2002) Detection of knockdown resistance mutations in Anopheles sacharovi (Diptera: Culicidae) and genetic [...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...]	GP00002532	para P35500	Physiology	L1014S	Anopheles sacharovi (species)	Anopheles sacharovi (species)	para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002533	para P35500	Physiology	L1014F	Anopheles sacharovi (species)	Anopheles sacharovi (species)	para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Pitzer JB; Kaufman PE (2011) Identification of a mutation associated with permethrin resistance in the para-type sodium channel o[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Olafson PU; Kaufman PE; Duvallet G (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002534	para P35500	Physiology	L1014H	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D	para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Kang S; Jung J; Lee S ; et al. (2012) The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles si[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002536	para P35500	Physiology	L1014C	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002537	para P35500	Physiology	L1014C in Nicaragua and Costa Rica individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D	para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002538	para P35500	Physiology	L1014F in Mexico individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D	para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Wang ZM; Li CX; Xing D ; et al. (2012) Detection and widespread distribution of sodium channel alleles characteristic of insecticide resist[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002539	para P35500	Physiology	L1014C	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Li CX; Wang ZM ; et al. (2012) First detection of multiple knockdown resistance (kdr)-like mutations in voltage-gated sodium channe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002540	para P35500	Physiology	L1014W	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Pridgeon Julia W; Appel Arthur G; Moar William J ; et al. (2002 ) Variability of resistance mechanisms in pyrethroid resistant German cockroaches (Dictyoptera: Blatte[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002541	para P35500	Physiology	F999S = F1020S - T to C at nt 2996 resulting in a phenylalanine999 to serine999 amino acid change	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Clark J Marshall; Lee Si Hyeock (2010 ) Cloning of a sodium channel gene and identification of mutations putatively associated with fenpropa[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002542	para P35500	Physiology	L1024V	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002543	para P35500	Physiology	A1549V = A1410V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002544	para P35500	Physiology	A1648V = A1494V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kawada H; Higa Y; Komagata O ; et al. (2009) Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroi[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002545	para P35500	Physiology	F1269C = F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus cinnabarinus carmine spider mite - (species) D	Intraspecific	Candidate Gene	Feng YN; Zhao S; Sun W ; et al. (2011) The sodium channel gene in Tetranychus cinnabarinus (Boisduval): identification and expression analy[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002546	para P35500	Physiology	F1538I	Tetranychus cinnabarinus carmine spider mite - (species)	Tetranychus cinnabarinus carmine spider mite - (species) D	para (kdr)	Tetranychus cinnabarinus carmine spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Tsagkarakou A; Van Leeuwen T; Khajehali J ; et al. (2009) Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-s[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002547	para P35500	Physiology	F1538I	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002548	para P35500	Physiology	M1524I	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Hubert J; Nesvorna M; Kamler M ; et al. (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00002549	para P35500	Physiology	F975L	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002550	para P35500	Physiology	F1528L+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]	GP00002551	para P35500	Physiology	F758L+L826P+I982V+M1055I = F1528L+L1596P+I1752V+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Kaufman PE; Duvallet G ; et al. (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002613	para P35500	Physiology	L1014F	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D	para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002614	para P35500	Physiology	M918I ATG>ATT	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002615	para P35500	Physiology	M918I ATG>ATA	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kushwah RBS; Kaur T; Dykes CL ; et al. (2020) A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegy[...]	GP00002625	para P35500	Physiology	F1534L - Phe (TTC) > Leu (CTC)	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002629	para P35500	Physiology	F1845Y	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002630	para P35500	Physiology	V1848I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002631	para P35500	Physiology	V1848I	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002632	para P35500	Physiology	F1845Y	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002644	para P35500	Physiology	super-kdr+D600N - super-kdr+D600N confers higher levels of resistance to seven pyrethroids relative to super-kdr.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002645	para P35500	Physiology	kdr+T929I - addition of T929I to the kdr mutation (L1014F) increased resistance to all pyrethroids (except etofenprox) and enhanced resistance by ~1000-fold to acrinathrin and flumethrin.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002646	para P35500	Physiology	F1534S	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002647	para P35500	Physiology	I1532T	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Fontaine S; Caddoux L; Brazier C ; et al. (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...] 1 Additional References Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00002649	para P35500	Physiology	L932F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Thompson M; Shotkoski F; ffrench-Constant R (1993) Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]	GP00000968	Rdl P25123	Physiology	Ala302Ser	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	resistance to dieldrin	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species) D	Intraspecific	Candidate Gene	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000969	Rdl P25123	Physiology	Ala302Ser	Anopheles arabiensis (species)	Anopheles arabiensis (species) D	resistance to dieldrin	Anopheles arabiensis (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000970	Rdl P25123	Physiology	Ala302Gly	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	resistance to dieldrin	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Alon M; Alon F; Nauen R (2008) Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associat[...]	GP00000971	Rdl P25123	Physiology	2 mutations	Bemisia tabaci (species)	Bemisia tabaci (species) D	resistance to dieldrin	Bemisia tabaci (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Kaku K; Matsumura F (1994) Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]	GP00000972	Rdl P25123	Physiology	Ala302Ser	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	resistance to dieldrin	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]	GP00000973	Rdl P25123	Physiology	Ala302Ser	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	resistance to dieldrin	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993) A point mutation in a Drosophila GABA receptor confers insecticide resistance. 2 Additional References Lee HJ; Rocheleau T; Zhang HG (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000974	Rdl P25123	Physiology	Ala302Ser - G9155164T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Rdl P25123	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Hypothenemus hampei coffee berry borer - (species) D	Intraspecific	Candidate Gene	Brun LO; Stuart J; Gaudichon V ; et al. (1995) Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...] 2 Additional References Navarro Lucio; Gongora Carmenza; Benavides Pablo (2010 ) Single nucleotide polymorphism detection at the Hypothenemus hampei Rdl gene by allele-specific PCR [...] Steichen JC; Brun LO (1994 ) A molecular diagnostic for endosulfan insecticide resistance in the coffee berry borer Hypothenemus [...]	GP00000977	Rdl P25123	Physiology	Ala302Ser	Hypothenemus hampei coffee berry borer - (species)	Hypothenemus hampei coffee berry borer - (species) D	resistance to dieldrin	Hypothenemus hampei coffee berry borer - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000978	Rdl P25123	Physiology	Ala302Ser	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	resistance to dieldrin	Musca domestica house fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anthony N; Unruh T; Ganser D ; et al. (1998) Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.	GP00000979	Rdl P25123	Physiology	Ala302Gly	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	resistance to dieldrin	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Periplaneta americana American cockroach - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000980	Rdl P25123	Physiology	Ala302Ser	Periplaneta americana American cockroach - (species)	Periplaneta americana American cockroach - (species) D	resistance to dieldrin	Periplaneta americana American cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Tribolium castaneum red flour beetle - (species)	Intraspecific	Candidate Gene	Miyazaki M; Matsumura F; Beeman RW (1995) DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...] 1 Additional References Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000981	Rdl P25123	Physiology	Ala302Ser	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species)	resistance to dieldrin	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Le Goff G; Hamon A; Bergé JB ; et al. (2005) Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]	GP00001981	Rdl P25123	Physiology	2 mutations	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	ffrench-Constant RH; Steichen JC; Rocheleau TA ; et al. (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00001982	Rdl P25123	Physiology	Ala301Ser - The lesion in the RdlMD-RR allele has been described as A302S in print but the amino acid replacement is actually A301S.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Remnant EJ; Good RT; Schmidt JM ; et al. (2013) Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster.	GP00002452	Rdl P25123	Physiology	113-kb duplication containing one WT copy of Rdl and a second copy with two point mutations: an Ala(301) to Ser resistance mutation and Met(360) to Ile replacement. Individuals with this duplication exhibit intermediate dieldrin resistance compared with single copy Ser(301) homozygotes and reduced temperature sensitivity and altered RNA editing associated with the resistant allele. Ectopic recombination between Roo transposable elements is involved in generating this genomic rearrangement. The duplication phenotypes were confirmed by construction of a transgenic artificial duplication integrating the 55.7-kb Rdl locus with a Ser(301) change into an Ala(301) background.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Wondji CS; Dabire RK; Tukur Z ; et al. (2011) Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the ma[...]	GP00002557	Rdl P25123	Physiology	2 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	resistance to dieldrin	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Domingues LN; Guerrero FD; Becker ME ; et al. (2013) Discovery of the Rdl mutation in association with a cyclodiene resistant population of horn flies, H[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002558	Rdl P25123	Physiology	Ala301Ser	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	resistance to dieldrin	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Tantely ML; Tortosa P; Alout H ; et al. (2010) Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002559	Rdl P25123	Physiology	Ala301Ser	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	resistance to dieldrin	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Tantely ML; Tortosa P; Alout H ; et al. (2010) Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002560	Rdl P25123	Physiology	Ala301Ser	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D	resistance to dieldrin	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Nakao T; Kawase A; Kinoshita A ; et al. (2011) The A2'N mutation of the RDL gamma-aminobutyric acid receptor conferring fipronil resistance in Laod[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002561	Rdl P25123	Physiology	A301N	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D	resistance to dieldrin	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Experimental Evolution	Candidate Gene	Li A; Yang Y; Wu S ; et al. (2006) Investigation of resistance mechanisms to fipronil in diamondback moth (Lepidoptera: Plutellidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002562	Rdl P25123	Physiology	A302(GGC)--> S302(TCC)	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	resistance to dieldrin	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Sogatella furcifera white-backed planthopper - (species) D	Experimental Evolution	Candidate Gene	Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010 ) Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002563	Rdl P25123	Physiology	2 mutations	Sogatella furcifera white-backed planthopper - (species)	Sogatella furcifera white-backed planthopper - (species) D	resistance to dieldrin	Sogatella furcifera white-backed planthopper - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Oulema oryzae rice leaf beetle - (species) D	Experimental Evolution	Candidate Gene	Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010 ) Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002564	Rdl P25123	Physiology	A301S	Oulema oryzae rice leaf beetle - (species)	Oulema oryzae rice leaf beetle - (species) D	resistance to dieldrin	Oulema oryzae rice leaf beetle - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Diabrotica virgifera (species) D	Intraspecific	Candidate Gene	Wang H; Coates BS; Chen H ; et al. (2013) Role of a γ-aminobutryic acid (GABA) receptor mutation in the evolution and spread of Diabrotica vir[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002566	Rdl P25123	Physiology	A301S	Diabrotica virgifera (species)	Diabrotica virgifera (species) D	resistance to dieldrin	Diabrotica virgifera (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Hope M; Menzies M; Kemp D (2010) Identification of a dieldrin resistance-associated mutation in Rhipicephalus (Boophilus) microplus ([...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002567	Rdl P25123	Physiology	T305L	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	resistance to dieldrin	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator