Gephebase

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Your research retrieved 110 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
ABCC2	Xenobiotic resistance (insecticide)	Coding, Insertion	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Atsumi S; Miyamoto K; Yamamoto K ; et al. (2012) Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin[...]	GP00000011	ABCC2 A0A0E3ZDK3	Physiology	1a.a. insertion at codon 234 (Tyr)	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	ABCC2	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Unknown, Unknown	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000014	ABCC2 A0A0E3ZDK3	Physiology	Not identified	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCC2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D	Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	G119S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	G119S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000030	Ace P07140	Physiology	331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D	Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Fournier D; Bride JM; Hoffmann F ; et al. (1992) Acetylcholinesterase. Two types of modifications confer resistance to insecticide. 1 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000032	Ace P07140	Physiology	Phe368 -> Tyr	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000033	Ace P07140	Physiology	Ile/Val199 -> Thr	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000034	Ace P07140	Physiology	Gly303 -> Ala	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000035	Ace P07140	Physiology	Phe115 -> Ser	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)	Acetylcholinesterase (Ace)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, Deletion	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008) A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...] 1 Additional References Kakani EG; Bon S; Massoulié J (2011) Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides.	GP00000038	Ace P07140	Physiology	9bp deletion of three glutamine residues at positions 642_644	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Haymer DS; Wu WJ ; et al. (2006) Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]	GP00000045	Ace P07140	Physiology	2 mutations	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Unknown N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]	GP00000160	BtR Q19KJ3	Physiology	premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	BTR1- Cadherin-like protein	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	BTR1- Cadherin-like protein	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Deletion	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000164	BtR Q19KJ3	Physiology	24bp in-frame deletion	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
CHKov1	Pathogen resistance Xenobiotic resistance (insecticide)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Magwire MM; Bayer F; Webster CL ; et al. (2011) Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...] 1 Additional References Aminetzach YT; Macpherson JM; Petrov DA (2005) Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila.	GP00000182	CHKov1 Q961V7	Physiology Physiology	Insertion of a Doc TE element resulting in novel; seemingly functional short protein	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CHKov1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chung H; Bogwitz MR; McCart C ; et al. (2007) Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]	GP00000207	Cyp6g1 Q9V674	Physiology	Insertion of retrotransposon A 291bp upstream of the Cyp6g1 transcription start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	cyp6g1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)	Xenobiotic resistance (insecticide)	Unknown, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Riveron JM; Irving H; Ndula M ; et al. (2013) Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...]	GP00000208	CYP2C9 P11712	Physiology	unknown but strong evidence of directional selection at these genes correlated with elevated expression	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9 cluster (CYP6P9a and CYP6P9b)	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP6P9; CYP6P4 cluster	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Wondji CS; Irving H; Morgan J ; et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...]	GP00000209	Q2YH43	Physiology	unknown; but 10-30 fold differences in expression levels between phenotypes	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9; CYP6P4 cluster	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
esterase B1 + esterase A	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Rooker S; Guillemaud T; Bergé J ; et al. (1996) Coamplification of esterase A and B genes as a single unit in Culex pipiens mosquitoes.	GP00000291	B1 P16854	Physiology	Amplification of a region containing both genes	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	esterase B1 + esterase A	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase B1 = esterase beta1	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Mouchès C; Pasteur N; Bergé JB ; et al. (1986) Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mo[...] 3 Additional References Guillemaud T; Raymond M; Tsagkarakou A (1999) Quantitative variation and selection of esterase gene amplification in Culex pipiens. Mouches C; Pauplin Y; Agarwal M (1990) Characterization of amplification core and esterase B1 gene responsible for insecticide resistance i[...] Guillemaud T; Rooker S; Pasteur N (1996) Testing the unique amplification event and the worldwide migration hypothesis of insecticide resista[...]	GP00000292	B1 P16854	Physiology	Amplification of esterase B1 only	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	esterase B1 = esterase beta1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase E4	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Field LM; Devonshire AL; Forde BG (1988) Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results[...]	GP00000293	P35501	Physiology	Whole gene amplification	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	esterase E4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Newcomb RD; Campbell PM; Ollis DL ; et al. (1997) A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]	GP00000294	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)	esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Jackson CJ; Liu JW; Carr PD ; et al. (2013) Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]	GP00000295	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)	esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species)	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000296	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species)	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000297	LcaE7 Q25252	Physiology	Trp251Ser	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000298	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E7 = E3	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Claudianos C; Russell RJ; Oakeshott JG (1999) The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]	GP00000299	LcaE7 Q25252	Physiology	Gly137Asp	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	esterase isozyme E7 = E3	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	2 mutations	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 1 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Franck P; Siegwart M; Olivares J ; et al. (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D	para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Linkage Mapping	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Linkage Mapping	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 2 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] Park Y; Taylor MF (1997) A novel mutation L1029H in sodium channel gene hscp associated with pyrethroid resistance for Heliot[...]	GP00000833	para P35500	Physiology	L1029H (=position L1014)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]	GP00000839	para P35500	Physiology	L925I	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000840	para P35500	Physiology	M918L	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.	GP00000841	para P35500	Physiology	L1014H	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Vais H; Williamson MS; Devonshire AL ; et al. (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. 1 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000846	para P35500	Physiology	T929I (ACC to ATC or ATA)	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000848	para P35500	Physiology	L1014F	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)	para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Thompson M; Shotkoski F; ffrench-Constant R (1993) Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]	GP00000968	Rdl P25123	Physiology	Ala302Ser	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	resistance to dieldrin	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species) D	Intraspecific	Candidate Gene	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000969	Rdl P25123	Physiology	Ala302Ser	Anopheles arabiensis (species)	Anopheles arabiensis (species) D	resistance to dieldrin	Anopheles arabiensis (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000970	Rdl P25123	Physiology	Ala302Gly	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	resistance to dieldrin	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Alon M; Alon F; Nauen R ; et al. (2008) Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associat[...]	GP00000971	Rdl P25123	Physiology	Ala302Ser	Bemisia tabaci (species)	Bemisia tabaci (species) D	resistance to dieldrin	Bemisia tabaci (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Kaku K; Matsumura F (1994) Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]	GP00000972	Rdl P25123	Physiology	Ala302Ser	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	resistance to dieldrin	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]	GP00000973	Rdl P25123	Physiology	Ala302Ser	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	resistance to dieldrin	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993) A point mutation in a Drosophila GABA receptor confers insecticide resistance. 2 Additional References Lee HJ; Rocheleau T; Zhang HG (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000974	Rdl P25123	Physiology	Ala302Ser - G9155164T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species) D	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Xmrk-2 Q91389	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species)	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Hypothenemus hampei coffee berry borer - (species) D	Intraspecific	Candidate Gene	Brun LO; Stuart J; Gaudichon V ; et al. (1995) Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...]	GP00000977	Rdl P25123	Physiology	Ala302Ser	Hypothenemus hampei coffee berry borer - (species)	Hypothenemus hampei coffee berry borer - (species) D	resistance to dieldrin	Hypothenemus hampei coffee berry borer - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000978	Rdl P25123	Physiology	Ala302Ser	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	resistance to dieldrin	Musca domestica house fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anthony N; Unruh T; Ganser D ; et al. (1998) Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.	GP00000979	Rdl P25123	Physiology	Ala302Gly	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	resistance to dieldrin	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Periplaneta americana American cockroach - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000980	Rdl P25123	Physiology	Ala302Ser	Periplaneta americana American cockroach - (species)	Periplaneta americana American cockroach - (species) D	resistance to dieldrin	Periplaneta americana American cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Tribolium castaneum red flour beetle - (species)	Intraspecific	Candidate Gene	Miyazaki M; Matsumura F; Beeman RW (1995) DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...] 1 Additional References Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000981	Rdl P25123	Physiology	Ala302Ser	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species)	resistance to dieldrin	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...] 1 Additional References Assogba BS; Djogbénou LS; Milesi P (2015) An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, [...]	GP00001372	Ace P07140	Physiology	Strict tandem duplication of 203kb encompassing 12 genes ; ace1 heterogeneous gene duplication (susceptible G119 and resistant S119 copies)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species)	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001373	Ace P07140	Physiology	Strict tandem 3 times duplication of 203kb encompassing 12 genes with partial internal deletion of 97kb in the third copy - ace1 homogeneous gene duplications (all 3 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species)	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001374	Ace P07140	Physiology	Strict tandem 5 times duplication of 203kb encompassing 12 genes - ace1 homogeneous gene duplications (all 5 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001689	para P35500	Physiology	L1014F; Haplotype H02	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001691	para P35500	Physiology	L1014S; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species)	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles vagus (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001692	para P35500	Physiology	L1014S	Anopheles vagus (species)	Anopheles vagus (species) D	para (kdr)	Anopheles vagus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001695	para P35500	Physiology	L1014S	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles paraliae (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001696	para P35500	Physiology	L1014S	Anopheles paraliae (species)	Anopheles paraliae (species)	para (kdr)	Anopheles paraliae (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001699	para P35500	Physiology	L1014F; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Cimex lectularius bed bug - (species) D	Intraspecific	Candidate Gene	Durand R; Cannet A; Berdjane Z ; et al. (2012) Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France. 2 Additional References Yoon KS; Kwon DH; Strycharz JP (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] Seong KM; Lee DY; Yoon KS (2010) Establishment of quantitative sequencing and filter contact vial bioassay for monitoring pyrethroid [...]	GP00001859	para P35500	Physiology	2 mutations	Cimex lectularius bed bug - (species)	Cimex lectularius bed bug - (species) D	para (kdr)	Cimex lectularius bed bug - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	González-Cabrera J; Rodríguez-Vargas S; Davies TG ; et al. (2016) Novel Mutations in the Voltage-Gated Sodium Channel of Pyrethroid-Resistant Varroa destructor Popula[...]	GP00001860	para P35500	Physiology	2 mutations	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D	para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Kapantaidaki DE; Sadikoglou E; Tsakireli D ; et al. (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001861	para P35500	Physiology	M918L - only found in samples from China	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Kapantaidaki DE; Sadikoglou E; Tsakireli D ; et al. (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001862	para P35500	Physiology	2 mutations	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)	para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species)	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001863	para P35500	Physiology	M918L - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).	Hyalella azteca (species)	Hyalella azteca (species)	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001864	para P35500	Physiology	L925V	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 1 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...]	GP00001865	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 1 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...]	GP00001866	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator