Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

Advanced Search

Field

Term

Summary Table

Your research retrieved 638 results.

Summary
Others

Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
ABCA1	Coloration (feathers) Cholesterol metabolism	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Attie AD; Hamon Y; Brooks-Wilson AR ; et al. (2002) Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of t[...]	GP00001682	Abca1 P41233	Morphology; Physiology Morphology; Physiology	amino acid substitution at a residue that is conserved in the ABCA1 gene between human; mouse; chicken; and Takifugu rubripes. Generation of a mouse ABCA1 protein with the mutation disrupts protein function. N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D	ABCA1	Gallus gallus chicken - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Indel N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000002	ABCA2 A0A0S0G7V0	Physiology	65bp indel in exon16 inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000003	ABCA2 A0A0S0G7V0	Physiology	5bp deletion inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000004	ABCA2 A0A0S0G7V0	Physiology	5bp (GAATA) nucleotide duplication inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002054	ABCA2 A0A0S0G7V0	Physiology	insertion of a transposon Tntransib (2581 bp) in ABCA2 which changes splicing sites in the transcript and lead to an indel in the coding region: change of 1551VETLAHALGFLRHLDKR1567 into 1551AHWGK- LYGSNTQN1563 N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00002056	ABCA2 A0A0S0G7V0	Physiology	14bp deletion resulting in missense mutations. N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D	ABCA2	Helicoverpa punctigera (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Candidate Gene	Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018) ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]	GP00002057	ABCA2 A0A0S0G7V0	Physiology	loss of exon 6 caused by alternative splicing N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	ABCA2	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002467	ABCA2 Q9BZC7	Physiology	insertion of a 2581-bp transposon Tntransib in ABCA2. This insertion disrupts splicing sites and leads to indels in the protein sequence. CRISPR ABCA2 mutants are highly resistant to Cry2Ab. N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCB1	Plant size (dwarfism)	Coding, Insertion N	Sorghum bicolor sorghum - (species)	Domesticated	Candidate Gene	Multani DS; Briggs SP; Chamberlin MA ; et al. (2003) Loss of an MDR transporter in compact stalks of maize br2 and sorghum dw3 mutants.	GP00000007	ABCB1 Q9ZR72	Morphology	882bp direct duplication in exon 5 of the dw3 allele driving loss-of-function N	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)	ABCB1	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
ABCB1	Xenobiotic resistance (insecticide; Bt Cry3Aa toxin)	Coding, Deletion N	Chrysomela tremula (species) D	Intraspecific	Candidate Gene	Pauchet Y; Bretschneider A; Augustin S ; et al. (2016) A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle[...]	GP00002466	ABCB1 P08183	Physiology	a four-base-pair deletion at position 1561 introducing a frame shift with a premature stop codon leading to loss of the TpM1 transporter motif as well as the complete second transmembrane domain N	Chrysomela tremula (species)	Chrysomela tremula (species) D	ABCB1	Chrysomela tremula (species)	Published - Accepted by Curator
Abcb4	Biliary Phospholipid Level (low)	Coding, Unknown N	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000008	Abcb4 P21440	Physiology	pseudogenization N	Mammalia mammals - (class)	Cavia porcellus domestic guinea pig - (species)	Abcb4	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
Abcb4	Biliary Phospholipid Level (low)	Coding, Unknown N	Equus caballus horse - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000009	Abcb4 P21440	Physiology	pseudogenization N	Mammalia mammals - (class)	Equus caballus horse - (species)	Abcb4	Equus caballus horse - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Deletion N	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014) ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]	GP00001439		Physiology	About 500 nt genomic deletion over 2 exons involving 246 nt coding 82aa N	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D	ABCC2	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Banerjee R; Hasler J; Meagher R ; et al. (2017) Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm[...] 1 Additional References Flagel L; Lee YW; Wanjugi H (2018) Mutational disruption of the ABCC2 gene in fall armyworm, Spodoptera frugiperda, confers resistance [...]	GP00002461	MRP1 H8YF43	Physiology	A nine-base deletion (position 39–47) and a two-base insertion (GC at position 2218) lead to a frameshift and the occurrence of a premature stop codon. The truncated protein is 746 amino acids whereas the ABCC2 of the susceptible strain encodes a protein of 1349 amino acids. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D	ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Boaventura D; Ulrich J; Lueke B ; et al. (2020) Molecular characterization of Cry1F resistance in fall armyworm, Spodoptera frugiperda from Brazil.	GP00002462	MRP1 H8YF43	Physiology	two mutations in the extracellular loop 4 (ECL4) of ABCC2: a deletion of two amino acids (GY) at positions 788 and 789 and the change of a proline to either lysine or arginine at position 799. Expression of mutated ABCC2 in insect cells confirmed the role of these mutations in toxin binding. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D	ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Calafell F; Roubinet F; Ramírez-Soriano A (2008) Evolutionary dynamics of the human ABO gene.	GP00000019	ABO P16442	Physiology	1bp deletion (258G) resulting in frameshift N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000021	ABO P16442	Physiology	1bp insertion resulting in premature stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000022	ABO P16442	Physiology	1bp change resulting in stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species)	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, Insertion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Cavanagh JA; Tammen I; Windsor PA ; et al. (2007) Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN.	GP00002140	ACAN P16112	Morphology	2266_2267insGGCA mutation introduces a frameshift and a premature termination codon into exon 11; the frameshift occurs at amino acid position 756 ; the termination codon occurs at position 914 compared to the normal aggrecan product of 2327 amino acids N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	aggrecan	Bos taurus cattle - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Cis-regulatory, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Cavanagh JA; Tammen I; Windsor PA ; et al. (2007) Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN.	GP00002141	ACAN P16112	Morphology	−198C>T transition predicted to introduce a new ATG start codon 199 bp upstream of the normal start codon N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	aggrecan	Bos taurus cattle - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Eberth JE; Graves KT; MacLeod JN ; et al. (2018) Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.	GP00002142	ACAN P16112	Morphology	g.95257458_95257500del ; p.Phe2017-Asp2023del N	Equus caballus horse - (species)	Equus caballus horse - (species) D	aggrecan	Equus caballus horse - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Eberth JE; Graves KT; MacLeod JN ; et al. (2018) Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.	GP00002145	ACAN P16112	Morphology	g.95291270del ; p.Lys82fs N	Equus caballus horse - (species)	Equus caballus horse - (species) D	aggrecan	Equus caballus horse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Gene Loss, Deletion N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000055	Asip Q03288	Morphology	125kb deletion including 5' CDS of Agouti N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)	Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Coding, SNP N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000056	Asip Q03288	Morphology	Premature stop codon at residue 65 N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)	Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Intraspecific	Linkage Mapping	Rieder S; Taourit S; Mariat D ; et al. (2001) Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their associati[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000062	Asip Q03288	Morphology	11bp deletion in exon 2: g.2174_2184del11 c.191_201del N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Agouti	Equus caballus horse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000063	Asip Q03288	Morphology	Deletion of nt 123-124 N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	Agouti	Felis catus domestic cat - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Panthera pardus leopard - (species) D	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000065	Asip Q03288	Morphology	nonsense mutation located in exon 4 (C333A) predicted to introduce a stop codon at amino acid position 111 N	Panthera pardus leopard - (species)	Panthera pardus leopard - (species) D	Agouti	Panthera pardus leopard - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Vulpes vulpes red fox - (species) D	Domesticated	Candidate Gene	Våge DI; Lu D; Klungland H ; et al. (1997) A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes.	GP00000067	Asip Q03288	Morphology	166 bp deletion in exon 1 N	Vulpes vulpes red fox - (species)	Vulpes vulpes red fox - (species) D	Agouti	Vulpes vulpes red fox - (species)	Published - Accepted by Curator
Agouti	Coloration (feathers)	Coding, Deletion N	Coturnix japonica Japanese quail - (species) D	Domesticated	Linkage Mapping	Hiragaki T; Inoue-Murayama M; Miwa M ; et al. (2008) Recessive black is allelic to the yellow plumage locus in Japanese quail and associated with a frame[...]	GP00000068	Asip Q03288	Morphology	8bp frameshift deletion N	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species) D	Agouti	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Leopardus colocolo Colocolo - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001731	Asip Q03288	Morphology	Arg to Cys substitution in the C-terminal region of ASIP (p.R120C) lies in the critical RFF loop (e.g. a triplet motif made of one arginine and two phenylalanine residues) required for binding to the MC1R N	Leopardus colocolo Colocolo - (species)	Leopardus colocolo Colocolo - (species) D	Agouti	Leopardus colocolo Colocolo - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Leopardus guigna Kodkod - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001732	Asip Q03288	Morphology	Cys to Tyr substitution in ASIP (p.C126Y) which affects the key disulfide bond that stabilizes the RFF loop N	Leopardus guigna Kodkod - (species)	Leopardus guigna Kodkod - (species) D	Agouti	Leopardus guigna Kodkod - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Gene Loss, Deletion N	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00001975	Asip Q03288	Morphology	125kb deletion ; recessive mutation N	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)	Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Association Mapping	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00001976	Asip Q03288	Morphology	recessive mutation at nucleotide position 193 (in exon 3) resulting in a change from glutamine to a stop codon at amino acid position 65 (Q65term) N	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)	Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat) Lifespan	2 Mutations: Coding N	Ovis aries sheep - (species) D	Intraspecific	Linkage Mapping	Gratten J; Pilkington JG; Brown EA ; et al. (2010) The genetic basis of recessive self-colour pattern in a wild sheep population. 1 Additional References Gratten J; Pilkington JG; Brown EA (2012) Selection and microevolution of coat pattern are cryptic in a wild population of sheep.	GP00001356	Asip Q03288	Morphology Physiology	2 mutations	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	Agouti (ASIP)	Ovis aries sheep - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Insertion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Fontanesi L; Forestier L; Allain D ; et al. (2010) Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic an[...] 1 Additional References Sakuma Y; Matsunami M; Takada T (2019) Multiple Conserved Elements Structuring Inverted Repeats in the Mammalian Coat Color-Related Gene As[...]	GP00001968	Asip Q03288	Morphology	an insertion in exon 2 of the black nonagouti allele = c.5_6insA mutation which causes a frameshift and a predicted truncated protein of only 21 amino acids N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	Agouti (ASIP)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Deletion N	D	Intraspecific	Candidate Gene	Miller SM; Guthrie AJ; Harper CK (2016) Single base-pair deletion in ASIP exon 3 associated with recessive black phenotype in impala (Aepyce[...]	GP00001977	Asip Q03288	Morphology	recessive c.174delA was found in all black phenotype sequences ; premature stop codon (239–241 bp) N		D	Agouti (ASIP)		Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Deletion N	Camelus dromedarius Arabian camel - (species) D	Domesticated	Candidate Gene	Almathen F; Elbir H; Bahbahani H ; et al. (2018) Polymorphisms in MC1R and ASIP Genes are Associated with Coat Color Variation in the Arabian Camel. 1 Additional References Alshanbari F; Castaneda C; Juras R (2019) Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Anal[...]	GP00001978	Asip Q03288	Morphology	1-bp deletion at position 23 resulting in frameshift N	Camelus dromedarius Arabian camel - (species)	Camelus dromedarius Arabian camel - (species) D	Agouti (ASIP)	Camelus dromedarius Arabian camel - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat; dorso-ventral)	Coding, Insertion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Letko A; Ammann B; Jagannathan V ; et al. (2020) A deletion spanning the promoter and first exon of the hair cycle-specific ASIP transcript isoform i[...]	GP00002373	Asip Q03288	Morphology	"The structural variant represented an approximately 11 kb deletion (NC_013672.1:g.5,455,408_5,466,123del; Fig. 2). In rabbit, there are currently two ASIP transcript isoforms annotated (NCBI annotation release 102). The deletion removes the entire first 5′-untranslated exon of one of these transcripts (NM_001122939.1). (...) he deletion removed the transcription start site and the first untranslated exon of the presumably hair cycle-specific transcript isoform, suggesting that this is the most likely causative variant for the black and tan phenotype." N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	Agouti (ASIP)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (TCDD)	Coding, SNP N	Rattus norvegicus Norway rat - (species) D	Intraspecific	Linkage Mapping	Tuomisto JT; Viluksela M; Pohjanvirta R ; et al. (1999) The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resista[...] 2 Additional References Moffat ID; Roblin S; Harper PA (2007) Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transac[...] Pohjanvirta R; Wong JM; Li W (1998) Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon[...]	GP00001813	Ahr P30561	Physiology	point mutation in the exon/intron 10 boundary in AHR genomic structure that leads to use of 3 alternative cryptic splice sites; potentially creating 3 alternative transcripts and 2 protein products. At the protein level the mutation leads to a total loss of either 43 or 38 amino acids (with altered sequence for the last seven amino acids in the latter case) toward the carboxyl-terminal end in the trans-activation domain of the AhR. H/W rats also harbor a point mutation in exon 10 that will cause a Val-to-Ala substitution in codon 497, but this occurs in a variable region of the AhR N	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D	AHR	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001806	Ahr P30561	Physiology	70 kb deletion that removes parts of the two genes AHR1a and AHR2a N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001807	Ahr P30561	Physiology	45 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 5 of AHR2a to exon 4 of AHR1a) N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001808	Ahr P30561	Physiology	83 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 11 of AHR2a to exon 6 of AHR1a) N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution; polychlorinated biphenyls; PCBs)	Coding, Deletion N	Microgadus tomcod Atlantic tomcod - (species) D	Intraspecific	Candidate Gene	Wirgin I; Roy NK; Loftus M ; et al. (2011) Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.	GP00001809	Ahr P30561	Physiology	6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain N	Microgadus tomcod Atlantic tomcod - (species)	Microgadus tomcod Atlantic tomcod - (species) D	AHR2	Microgadus tomcod Atlantic tomcod - (species)	Published - Accepted by Curator
AIP	Xenobiotic resistance (pollution)	Unknown, Unknown N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.	GP00001812	Aip O08915	Physiology	exact mutation(s) unknown - very good candidate gene according to association mapping and knowledge about the physiology N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AIP	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Freeth AL; Gibson JB; Wilks AV (1990) Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...] 1 Additional References Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001990	Adh P00334	Physiology	eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001991	Adh P00334	Physiology	438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Allantoin permease DAL4	Nitrogen use (growth rate on allantoin)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001503	DAL4 Q04895	Physiology	c.1201delA a single nucleotide frameshifting insertion (deletion?) N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Allantoin permease DAL4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ameloblastin (AMBN)	Tooth absence (no enamel production)	Gene Loss, Deletion N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001934	AMBN Q9NP70	Physiology	synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	ameloblastin (AMBN)	Gallus gallus chicken - (species)	Published - Accepted by Curator
ameloblastin (AMBN)	Tooth absence (no enamel production)	Coding, Unknown N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Deméré TA; McGowen MR; Berta A ; et al. (2008) Morphological and molecular evidence for a stepwise evolutionary transition from teeth to baleen in [...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001938	AMBN Q9NP70	Physiology	multiple frameshift mutations N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D	ameloblastin (AMBN)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
amelogenin (AMEL)	Tooth absence (no enamel production)	3 Mutations: Coding N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001933	Amelx P63277	Physiology	3 mutations	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	amelogenin (AMEL)	Gallus gallus chicken - (species)	Published - Accepted by Curator
amelogenin (AMEL)	Tooth absence (no enamel production)	Coding, Unknown N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001937	Amelx P63277	Physiology	J. Gatesy 2010 unpublished data cited in the main reference N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D	amelogenin (AMEL)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
Aminopeptidase N (APN)	Xenobiotic resistance (insecticide; Bt Cry2Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Experimental Evolution	Candidate Gene	Yang Y; Zhu YC; Ottea J ; et al. (2010) Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacil[...]	GP00002463	apn Q9VFX3	Physiology	deletion removing 22 amino acids. The mutant form failed to bind Cry1Ac unlike the full-length susceptible form. N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Aminopeptidase N (APN)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000089	AN2 A4GRU8	Morphology	1bp deletion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000090	AN2 A4GRU8	Morphology	4bp insertion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000091	AN2 A4GRU8	Morphology	W196* N	Petunia integrifolia (species)	Petunia axillaris (species)	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000092	AN2 A4GRU8	Morphology	1bp deletion; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000093	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000094	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
AOP2	Glucosinolate content	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000095	AOP2 Q945B5	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AOP2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
APSR	Sulfate content (shoot)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007) Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.	GP00000100	APR2 P92981	Physiology	A399E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	APSR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	2 Mutations: Coding SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001872	AQP1 P29972	Physiology	2 mutations	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001873	AQP1 P29972	Physiology	aquaporin yeast 1 gene on chromosome 12 - A881 deletion renders AQY1 inactive - size of the deletion not indicated in the paper - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001874	AQP1 P29972	Physiology	aquaporin yeast 1 gene on chromosome 12 - 955-bp deletion that removes the first 106 bp of AQY1 and its upstream region - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Carbrey JM; Bonhivers M; Boeke JD (2001) Aquaporins in Saccharomyces: Characterization of a second functional water channel protein.	GP00001875	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - 11-bp deletion that creates a stop codon in the middle of the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Laizé V; Tacnet F; Ripoche P (2000) Polymorphism of Saccharomyces cerevisiae aquaporins.	GP00001876	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - deletion of nucleotide G at position 25 (G25) which creates a frameshift the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]	GP00001877	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - G528 deletion which creates a frameshift the AQY2 gene - tested in assays - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
arcp-1	CO2 avoidance Aggregation behavior	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Beets I; Zhang G; Fenk LA ; et al. (2019) Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Alteri[...]	GP00002067	CELE_F34D10.6 C6KRH4	Behavior Behavior	8 bp deletion (mfP22) in the open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	arcp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
ARHGAP11B	Neocortex development (basal progenitor amplification)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Florio M; Namba T; Pääbo S ; et al. (2016) A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.	GP00001442	ARHGAP11B Q3KRB8	Morphology	c.661C>G new splice site mutation removing 55nt from exon 5 truncating a GAP domain N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ARHGAP11B	Homo sapiens human - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000106	GA20OX1 Q39110	Morphology	Whole gene deletion N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000107	GA20OX1 Q39110	Morphology	-2bp at +297 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000108	GA20OX1 Q39110	Morphology	-1bp "G" at +324 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000109	GA20OX1 Q39110	Morphology	-5bp "G" at +545 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000110	GA20OX1 Q39110	Morphology	-10bp "G" at +784 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000111	GA20OX1 Q39110	Morphology	-29bp at +426 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000112	GA20OX1 Q39110	Morphology	-444bp at +985 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000113	GA20OX1 Q39110	Morphology	+1bp "G" at +256 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000114	GA20OX1 Q39110	Morphology	+7bp "G" at +961 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000115	GA20OX1 Q39110	Morphology	+1bp at +1270 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000116	GA20OX1 Q39110	Morphology	Transposon insertion at +1355 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000117	GA20OX1 Q39110	Morphology	W46* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...] 1 Additional References Xu YL; Li L; Wu K (1995) The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cl[...]	GP00000118	GA20OX1 Q39110	Morphology	W271* -G816A according to Fig.3 of Xu et al. 1995 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000119	GA20OX1 Q39110	Morphology	E312* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Luo Y; Dong X; Yu T ; et al. (2015) A Single Nucleotide Deletion in Gibberellin20-oxidase1 Causes Alpine Dwarfism in Arabidopsis.	GP00001243	GA20OX1 Q39110	Morphology	-1bp at position 184 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001908	ATP4A P20648	Physiology	Absence of the gene in the genome sequence N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	ATP4A	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001920	ATP4A P20648	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species) Oreochromis niloticus Nile tilapia - (species)	Danio rerio zebrafish - (species) D	ATP4A	Danio rerio zebrafish - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001922	ATP4A P20648	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	ATP4A	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001928	ATP4A P20648	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	ATP4A	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	3 Mutations: Coding N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001909	ATP4B P51164	Physiology	3 mutations	Monodelphis domestica gray short-tailed opossum - (species) Homo sapiens human - (species)	Ornithorhynchus anatinus platypus - (species) D	ATP4B	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Callorhinchus milii elephant shark - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001916	ATP4B P51164	Physiology	Absence of the gene in the genome sequence N	Scyliorhinus canicula smaller spotted catshark - (species)	Callorhinchus milii elephant shark - (species) D	ATP4B	Callorhinchus milii elephant shark - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001921	ATP4B P51164	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species) Oreochromis niloticus Nile tilapia - (species)	Danio rerio zebrafish - (species) D	ATP4B	Danio rerio zebrafish - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001923	ATP4B P51164	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	ATP4B	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001929	ATP4B P51164	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	ATP4B	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
B2	Coloration (bulb)	Cis-regulatory, Insertion N	Allium cepa onion - (species) D	Domesticated	Linkage Mapping	Jo C; Kim S (2019) Transposition of a non-autonomous DNA transposon in the gene coding for a bHLH transcription factor [...]	GP00002058		Morphology	577-bp insertion of a transposable element named AcWHITE in the 5′ upstream region of the white allele of B2. A 8-bp target site duplication (GTTATA AC) and a 7-bp terminal inverted repeat (CAAGGTT) were identified at both ends of this insertion - no SNP detected in the coding region N	Allium cepa onion - (species)	Allium cepa onion - (species) D	B2	Allium cepa onion - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Bradbury LM; Fitzgerald TL; Henry RJ ; et al. (2005) The gene for fragrance in rice. 1 Additional References Kovach MJ; Calingacion MN; Fitzgerald MA (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00000134	BADH2 Q84LK3	Physiology	8bp deletion resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species)	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Shi Weiwei; Yang Yi; Chen Saihua ; et al. (2008 ) Discovery of a new fragrance allele and the development of functional markers for the breeding of fr[...] 1 Additional References Kovach MJ; Calingacion MN; Fitzgerald MA (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001772	BADH2 Q84LK3	Physiology	7-bp deletion in exon 2 resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001773	BADH2 Q84LK3	Physiology	2-bp deletion in exon 1 resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001774	BADH2 Q84LK3	Physiology	insertion of 1 bp (T) in exon 10 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001775	BADH2 Q84LK3	Physiology	G>T substitution in exon 10 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001776	BADH2 Q84LK3	Physiology	G>T substitution in exon 14 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001777	BADH2 Q84LK3	Physiology	C>T substitution in exon 13 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001778	BADH2 Q84LK3	Physiology	1-bp deletion in exon 10 - causes a frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001779	BADH2 Q84LK3	Physiology	1-bp insertion (G) in exon 14 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001780	BADH2 Q84LK3	Physiology	3-bp insertion (TAT) in exon 13 - causes a frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BBS9 (+ BMPER)	Growth rate	Coding, Deletion N	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Association Mapping	Derks MFL; Lopes MS; Bosse M ; et al. (2018) Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes[...]	GP00002341	Bbs9 Q811G0	Physiology	212kb deletion resulting in truncated BBS9 protein and recessive loss of neighbor gene expression BMPER N	Sus scrofa domesticus domestic pig - (subspecies)	Sus scrofa domesticus domestic pig - (subspecies) D	BBS9 (+ BMPER)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow serum)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Berry SD; Davis SR; Beattie EM ; et al. (2009) Mutation in bovine beta-carotene oxygenase 2 affects milk color. 1 Additional References Tian R; Pitchford WS; Morris CA (2010) Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colou[...]	GP00000138	BCO2 Q9BYV7	Physiology	c.306G>A ; p.W102* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	BCO2 = beta-carotene oxygenase 2	Bos taurus cattle - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow fat)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Våge DI; Boman IA (2010) A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumula[...] 1 Additional References Niu Y; Jin M; Li Y (2017) Biallelic β-carotene oxygenase 2 knockout results in yellow fat in sheep via CRISPR/Cas9.	GP00000140	BCO2 Q9BYV7	Physiology	g.21947481C>T ; c.196C>T ; p.Q66* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BCO2 = beta-carotene oxygenase 2	Ovis aries sheep - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (bill, legs)	Coding, SNP N	Serinus canaria common canary - (species) D	Domesticated	Association Mapping	Gazda MA; Toomey MB; Araújo PM ; et al. (2020) GENETIC BASIS OF DE NOVO APPEARANCE OF CAROTENOID ORNAMENTATION IN BARE-PARTS OF CANARIES.	GP00002039	BCO2 Q9BYV7	Morphology	point mutation at nucleotide position 837,806 that is predicted to be a nonsynonymous mutation in the exon 9 of the BCO2 gene. This variant results in the substitution of a histidine for an arginine at residue 413 of the protein (R413H) . In silico analysis suggests that the R413H could cause structural distortion of the protein and lead to a possible loss of activity. In vitro assays with the urucum BCO2 variant show that the enzyme activity is lost. N	Serinus canaria common canary - (species)	Serinus canaria common canary - (species) D	BCO2 = beta-carotene oxygenase 2	Serinus canaria common canary - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow fat)	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Strychalski J; Brym P; Czarnik U ; et al. (2015) A novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits.	GP00002152	BCO2 Q9BYV7	Physiology	AAT-deletion mutation at Asp codon 248 of the BCO2 gene located at the beginning of exon 6 which results in the removal of an Asp N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	BCO2 = beta-carotene oxygenase 2	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001263	BGLU6 Q682B4	Physiology	T-> A of a splice site at position 168 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001264	BGLU6 Q682B4	Physiology	1-bp deletion of a splice site at position 395 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001265	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 913 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001266	BGLU6 Q682B4	Physiology	A deletion of one nucleotide in the seventh exon (BGLU6 CDS position 678) results in a premature stop codon in the accessions Bor-4, Se-0, Uod-1, and Zdr-1. premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001267	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 1138 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001830	TUB2 P02557	Physiology	A185P - missense_variant_c.553G>C_3539974 – A185P N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001832	TUB2 P02557	Physiology	stop_gained_HIGH_c.1267C>T_3538394 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001833	TUB2 P02557	Physiology	Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001834	TUB2 P02557	Physiology	missense_variant_MODERATE_c.1210G>A_3538451 – D404N N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001835	TUB2 P02557	Physiology	Del_3539006_3539808 – 802bp deletion of coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001836	TUB2 P02557	Physiology	stop_gained_HIGH_c.1135A>T_3539335 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001837	TUB2 P02557	Physiology	stop_gained_HIGH_c.1112C>A_3539358 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001838	TUB2 P02557	Physiology	Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001839	TUB2 P02557	Physiology	Del_3539470_3539471 – 1bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001840	TUB2 P02557	Physiology	Del_3539507_3539514 – 7bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001841	TUB2 P02557	Physiology	Del_3539559_3539745 – 186 bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001842	TUB2 P02557	Physiology	Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001843	TUB2 P02557	Physiology	missense_variant_MODERATE_c.771G>A_3539699 – M257I N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001844	TUB2 P02557	Physiology	Del_3539746_3539908 – 162 bp deletion in exon3-4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001845	TUB2 P02557	Physiology	stop_gained_HIGH_c.549C>A_3539978 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001846	TUB2 P02557	Physiology	missense_variant_MODERATE_c.434C>T_3540145 – S145F N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001847	TUB2 P02557	Physiology	missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001848	TUB2 P02557	Physiology	Del_3540300_3540301 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Inversion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001849	TUB2 P02557	Physiology	Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Unknown N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001850	TUB2 P02557	Physiology	Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001851	TUB2 P02557	Physiology	Del_3540407_3540408 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001852	TUB2 P02557	Physiology	Del_3540970_3544000 – 3030bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001853	TUB2 P02557	Physiology	Del_3541317_3541856 – 539 bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001854	TUB2 P02557	Physiology	splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001855	TUB2 P02557	Physiology	stop_gained_HIGH_c.153T>G_3541441 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001856	TUB2 P02557	Physiology	Del_3541499_3541502 – 3bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001857	TUB2 P02557	Physiology	Ins_3541547_3541548 – 1 bp insertion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
Bh4	Coloration (seed hull)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Zhu BF; Si L; Wang Z ; et al. (2011) Genetic control of a transition from black to straw-white seed hull in rice domestication. 1 Additional References Huang X; Kurata N; Wei X (2012) A map of rice genome variation reveals the origin of cultivated rice.	GP00000143	Bh4 A0A0H3ZGK8	Morphology	22-bp deletion N	Oryza rufipogon (species)	Oryza sativa rice - (species) D	Bh4	Oryza sativa rice - (species)	Published - Accepted by Curator
bHLH2	Coloration (flower; seed)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Park KI; Ishikawa N; Morita Y ; et al. (2007) A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthe[...]	GP00002078	BHLH2 Q9CAD0	Morphology	two copies of 3.9-kb Tip100 integrated into bHLH2 exon 7 and intron 2 N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D	bHLH2	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
bHLH2	Coloration (flower; seed)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Park KI; Ishikawa N; Morita Y ; et al. (2007) A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthe[...]	GP00002085	BHLH2 Q9CAD0	Morphology	only one copy of Tip100 in exon 7 and no apparent footprint of Tip100 in intron 2 N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D	bHLH2	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
bHLH2	Coloration (flower; seed)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Park KI; Ishikawa N; Morita Y ; et al. (2007) A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthe[...]	GP00002086	BHLH2 Q9CAD0	Morphology	insertion of 838 bp IpMu1 in exon 2 N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D	bHLH2	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
bHLH2	Coloration (flowers; seeds)	Coding, Insertion N	Ipomoea tricolor (species) D	Domesticated	Candidate Gene	Park KI; Choi JD; Hoshino A ; et al. (2004) An intragenic tandem duplication in a transcriptional regulatory gene for anthocyanin biosynthesis c[...]	GP00002091	BHLH2 Q9CAD0	Morphology	intragenic tandem duplication of 3.3 kbp of the bHLH2 gene. Each of the tandem repeats is flanked by a 3-bp sequence AAT; indicating that the 3-bp microhomology is used to generate the tandem duplication. The transcripts in the pale-blue flower buds of the mutant contain an internal 583-bp tandem duplication that results in the production of a truncated polypeptide lacking the bHLH domain. The mRNA accumulation of most of the structural genes encoding enzymes for anthocyanin biosynthesis in the flower buds of the mutant was significantly reduced. The transcripts identical to the wild-type mRNAs for the transcriptional activator were present abundantly in blue spots of the variegated flowers whereas the transcripts containing the 583-bp tandem duplication were predominant in the pale-blue background of the same flowers. The flower and seed variegations studied here are likely to be caused by somatic homologous recombination between an intragenic tandem duplication in the gene encoding a bHLH transcriptional activator for anthocyanin biosynthesis. N	Ipomoea tricolor (species)	Ipomoea tricolor (species) D	bHLH2	Ipomoea tricolor (species)	Published - Accepted by Curator
bHLH2	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Domesticated	Candidate Gene	Spelt C; Quattrocchio F; Mol J ; et al. (2002) ANTHOCYANIN1 of petunia controls pigment synthesis, vacuolar pH, and seed coat development by geneti[...]	GP00002092	BHLH2 Q9CAD0	Morphology	insertion of a dTph1 transposon in the AN1 gene N	Petunia axillaris (species)	Petunia axillaris (species) D	bHLH2	Petunia axillaris (species)	Published - Accepted by Curator
Bm-iAANAT	Coloration (larva)	Coding, Deletion N	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Zhan S; Guo Q; Li M ; et al. (2010) Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation. 1 Additional References Dai FY; Qiao L; Tong XL (2010) Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism[...]	GP00000145	Aanat D6MKR2	Morphology	126-bp deletion overlapping with end of exon 4 and resulting in misplicing. Linkage analysis and genomic studies have shown that Bombyx arylalkamine-N-acetyl transferase, the homologous gene (Dat) that converts dopamine into N-acetyl dopamine, encodes a precursor of N-acetyl dopamine, sclerotin in Drosophila and it is the gene responsible for mln. N	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	Bm-iAANAT	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001488	BMH1 P29311	Physiology	C>G p.Y216* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001489	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001490	BMH1 P29311	Physiology	A>T p.K217* (2 times independently). Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001492	BMH1 P29311	Physiology	T>G p.L230* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001494	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000147	Bmp15 Q9Z0L4	Physiology	c.67C>T p.Q23* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004) Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]	GP00002155	Bmp15 Q9Z0L4	Physiology	c.718C>T ; p.Q239* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Martinez-Royo A; Jurado JJ; Smulders JP ; et al. (2008) A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in R[...] 1 Additional References Monteagudo LV; Ponz R; Tejedor MT (2009) A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolif[...]	GP00002158	Bmp15 Q9Z0L4	Physiology	c.525_541del17 p.Pro45Asnfs*54 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, Insertion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Lassoued N; Benkhlil Z; Woloszyn F ; et al. (2017) FecX a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine [...]	GP00002159	Bmp15 Q9Z0L4	Physiology	C insertion (c.310insC) in the ovine BMP15 cDNA leading to a frame shift at protein position 101 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BNA1	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001878	BNA1 P47096	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA1	[Candida] glabrata (species)	Published - Accepted by Curator
BNA2	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001879	P47125	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA2	[Candida] glabrata (species)	Published - Accepted by Curator
BNA4	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001880	BNA4 P38169	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA4	[Candida] glabrata (species)	Published - Accepted by Curator
BNA5	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001881	BNA5 Q05979	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA5	[Candida] glabrata (species)	Published - Accepted by Curator
BNA6	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001882	BNA6 P43619	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA6	[Candida] glabrata (species)	Published - Accepted by Curator
Brevis radix (BRX)	Root size (shorter)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Mouchel CF; Briggs GC; Hardtke CS (2004) Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell prolifer[...]	GP00000157	BRX Q17TI5	Morphology	premature stop codon in exon 4; TGG>TGA; truncated protein missing approximately two-thirds of the C terminus N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Brevis radix (BRX)	pH tolerance (acidic soil)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gujas B; Alonso-Blanco C; Hardtke CS (2012) Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil.	GP00001236	BRX Q17TI5	Physiology	K188* (stop codon) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
BTN1A1	Pathogen resistance (virus)	Coding, SNP N	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Elleder D; Stepanets V; Melder DC ; et al. (2005) The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian but[...]	GP00002160	BTN1A1 Q13410	Physiology	g.808011C>A c.165C>A p.C55* N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)	BTN1A1	Gallus gallus chicken - (species)	Published - Accepted by Curator
btr1	Seed shattering (grain dispersal ; retention)	Coding, Deletion N	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	Domesticated	Linkage Mapping	Pourkheirandish M; Hensel G; Kilian B ; et al. (2015) Evolution of the Grain Dispersal System in Barley.	GP00001445	BTR1 A0A0K1RJT0	Physiology	1bp deletion at position 202 inducing a frameshift N	Hordeum vulgare (species)	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	btr1	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies)	Published - Accepted by Curator
btr2	Seed shattering (grain dispersal ; retention)	Coding, Deletion N	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	Domesticated	Linkage Mapping	Pourkheirandish M; Hensel G; Kilian B ; et al. (2015) Evolution of the Grain Dispersal System in Barley.	GP00001446	BTR2 A0A0K1RKV9	Physiology	11bp deletion at position 254-264 creating a frameshift N	Hordeum vulgare (species)	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	btr2	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies)	Published - Accepted by Curator
BvCPSF73-Ia	Bolting time	Coding, Deletion N	Beta vulgaris (species) D	Intraspecific	Linkage Mapping	Tränkner C; Lemnian IM; Emrani N ; et al. (2016) A Detailed Analysis of the BR Locus Suggests a New Mechanism for Bolting after Winter in Sugar Beet [...]	GP00001411	CPSF73-I Q9C952	Physiology	2bp deletion causing a frameshift resulting in a two third truncated protein N	Beta vulgaris (species)	Beta vulgaris (species) D	BvCPSF73-Ia	Beta vulgaris (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, Unknown N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]	GP00000160	BtR Q19KJ3	Physiology	premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	cadherin	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	cadherin	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, SNP N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Walsh T; James B; Chakroun M ; et al. (2018) Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]	GP00002055	BtR Q19KJ3	Physiology	splice site GT mutated in GA so that splicing does not occur correctly and a 58 bp insertion is found in the cDNA sequence of the cadherin gene. This insertion disrupts the coding sequence in cadherin domain 9 causing a downstream frameshift and a premature stop codon for the rest of the protein. This would result in a truncated protein of 1243 amino acids without the putative binding domain; the membrane anchoring domain; presumably retained inside the cell and not exposed to the Cry1Ac; or alternatively; exported into the gut where it would be degraded N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D	cadherin	Helicoverpa punctigera (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Fabrick JA; Mathew LG; Tabashnik BE (2011) Insertion of an intact CR1 retrotransposon in a cadherin gene linked with Bt resistance in the pink [...]	GP00002449	A0A1B0RHM4	Physiology	insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon designated CR1-1_Pg. Unlike most other CR1 elements CR1-1_Pg is intact and transcribed by a flanking promoter. It contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002450	A0A1B0RHM4	Physiology	24-bp deletion in putative exon 21 causing the loss of eight amino acid residues N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002451	A0A1B0RHM4	Physiology	126-bp deletion spanning a putative intron 15/exon 16 splice site that introduces a premature stop codon and causes loss of the final 929 amino acid residues. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cathepsin E	Digestion (absence of stomach)	2 Mutations: Coding N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001910	CTSE P14091	Physiology	2 mutations	Monodelphis domestica gray short-tailed opossum - (species) Homo sapiens human - (species)	Ornithorhynchus anatinus platypus - (species) D	cathepsin E	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
Cauliflower (BoCAL)	Inflorescence morphology	Coding, SNP N	Brassica oleracea var. botrytis (varietas) D	Domesticated	Candidate Gene	Kempin SA; Savidge B; Yanofsky MF (1995) Molecular basis of the cauliflower phenotype in Arabidopsis. 1 Additional References Purugganan MD; Boyles AL; Suddith JI (2000) Variation and selection at the CAULIFLOWER floral homeotic gene accompanying the evolution of domest[...]	GP00000173	CAL Q39081	Morphology	GAG>TAG; E151*; protein truncated after only 150 of the 255 amino acids of the wild-type protein N	Brassica oleracea wild cabbage - (species)	Brassica oleracea var. botrytis (varietas) D	Cauliflower (BoCAL)	Brassica oleracea var. botrytis (varietas)	Published - Accepted by Curator
Cf-2.1 and Cf-2.2	Pathogen resistance (leaf mold fungus ; root parasitic nematode)	Gene Loss, Deletion N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Dixon MS; Jones DA; Keddie JS ; et al. (1996) The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat[...] 2 Additional References Dixon MS; Hatzixanthis K; Jones DA (1998) The tomato Cf-5 disease resistance gene and six homologs show pronounced allelic variation in leucin[...] Lozano-Torres JL; Wilbers RH; Gawronski P (2012) Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence t[...]	GP00000180	Q41398	Physiology	loss of the two genes Cf-2.1 and Cf-2.2 (see Dixon et al. 1998) in cultivated tomato - resistance re-acquired from related species N	Solanum pimpinellifolium (species)	Solanum lycopersicum tomato - (species) D	Cf-2.1 and Cf-2.2	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
chordin	Fin morphology (skeleton; dorsal fin; caudal fin; tail; paired fin)	Coding, SNP N	Carassius auratus goldfish - (species) D	Domesticated	Candidate Gene	Abe G; Lee SH; Chang M ; et al. (2014) The origin of the bifurcated axial skeletal system in the twin-tail goldfish. 1 Additional References Kon T; Omori Y; Fukuta K (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002346	chdA W8VTE1	Morphology	stop codon in codon 127. GAG (E) -> TAG (STOP). Predicted to result in a truncated protein lacking the second to fourth CR domains. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D	chordin	Carassius auratus goldfish - (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	3 Mutations: N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001391	CNL A0A172W603	Physiology	3 mutations	Petunia axillaris (species)	Petunia exserta (species) D	Cinnamate-CoA ligase 1 (CNL1)	Petunia exserta (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, SNP N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001767	CNL A0A172W603	Physiology	serine-to-arginine exchange at position 453 (T-to-A nucleotide exchange at genomic position 7 539 424) - this mutation is located immediately next to highly conserved amino acids predicted to be involved in adenosine monophosphate and coenzyme A binding; it involves two biochemically very dissimilar amino acids; and the serine at this position is conserved N	Capsella grandiflora (species)	Capsella rubella (species) D	Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, Deletion N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001768	CNL A0A172W603	Physiology	a 4 bp deletion resulting in a frameshift 795 bp downstream of the start codon and causing a premature stop codon N	Capsella grandiflora (species)	Capsella rubella (species) D	Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
CINNAMOYL CO-A REDUCTASE 1	Fiber content	Coding, Unknown N	Brassica napus rape - (species)	Domesticated	Linkage Mapping	Liu L; Stein A; Wittkop B ; et al. (2012) A knockout mutation in the lignin biosynthesis gene CCR1 explains a major QTL for acid detergent lig[...]	GP00000186	CCR1 Q9S9N9	Physiology	Frameshift mutation in exon1 N	Brassica napus rape - (species)	Brassica napus rape - (species)	CINNAMOYL CO-A REDUCTASE 1	Brassica napus rape - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, Deletion N	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Kehl A; Heimberger K; Langbein-Detsch I (2018) Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping sch[...]	GP00002165	Cmah Q61419	Physiology	c.1322delT p.Leu441* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, SNP N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002102	Q95WY5	Physiology	Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin. N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Insertion N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002103	Q95WY5	Physiology	Insertion of a 451-bpTE into the exon 2 of the toxin receptor gene. The insertion induces a new mRNA splicing event that creates a shorter transcript. This new transcript encodes an altered receptor unable to interact with the toxin resulting in resistance to this insecticide. The missing portion includes GPI-anchoring signals N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Deletion N	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Guo QY; Cai QX; Yan JP ; et al. (2013) Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaeri[...] 1 Additional References Darboux I; Pauchet Y; Castella C (2002) Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.	GP00002552	Q95WY5	Physiology	one-nucleotide deletion which results in a premature stop codon and leads to production of a truncated protein. N	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	Cpm1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
CS	Plant secondary metabolite (pungency)	Cis-regulatory, Deletion N	Capsicum annuum (species) D	Domesticated	Candidate Gene	Kim S; Park M; Yeom SI ; et al. (2014) Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...] 1 Additional References Stewart C; Kang BC; Liu K (2005) The Pun1 gene for pungency in pepper encodes a putative acyltransferase.	GP00001447	csy1 Q09UW1	Physiology	Large 2.5 kb deletion spanning 1.8 kb of the putative promoter and 0.7 kb of the first exon was observed in the C. annuum Bellpeppers N	Capsicum frutescens (species)	Capsicum annuum (species) D	CS	Capsicum annuum (species)	Published - Accepted by Curator
CYC8	Salt tolerance (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000195	CYC8 P14922	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	CYC8	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CYP(T)	Flower morphology (style length)	Coding, Insertion N	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001394	CYP734A1 O48786	Morphology	single base insertion in exon 2 introduces a disruptive premature stop codon N	Primula vulgaris (species)	Primula vulgaris (species) D	CYP(T)	Primula vulgaris (species)	Published - Accepted by Curator
CYP2J19	Coloration (red vs yellow beak)	Gene Loss, Deletion N	Taeniopygia guttata zebra finch - (species) D	Domesticated	Linkage Mapping	Mundy NI; Stapley J; Bennison C ; et al. (2016) Red Carotenoid Coloration in the Zebra Finch Is Controlled by a Cytochrome P450 Gene Cluster.	GP00000202	CYP2J2 P51589	Morphology	13kb deletion including complete loss of the CYP2J19A copy and cis-regulatory effects on CYP2J19B N	Taeniopygia guttata zebra finch - (species)	Taeniopygia guttata zebra finch - (species) D	CYP2J19	Taeniopygia guttata zebra finch - (species)	Published - Accepted by Curator
CYP76AD1	Coloration	Coding, Insertion N	Beta vulgaris (species) D	Domesticated	Linkage Mapping	Hatlestad GJ; Sunnadeniya RM; Akhavan NA ; et al. (2012) The beet R locus encodes a new cytochrome P450 required for red betalain production.	GP00000210	CYP76AD1 I3PFJ5	Morphology	5bp insertion resulting in frameshift N	Beta vulgaris (species)	Beta vulgaris (species) D	CYP76AD1	Beta vulgaris (species)	Published - Accepted by Curator
CYP79D15	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000211	CYP79D15 B2Y2T9	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D	CYP79D15	Trifolium repens white clover - (species)	Published - Accepted by Curator
DCAR-032551	Carotenoid content	Coding, Insertion N	Daucus carota carrot - (species) D	Domesticated	Linkage Mapping	Iorizzo M; Ellison S; Senalik D ; et al. (2016) A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid[...]	GP00001568	DCAR_032551 A0A162A3G8	Morphology	A 212-nt insertion in exon 2 that creates a frameshift mutation N	Daucus carota carrot - (species)	Daucus carota carrot - (species) D	DCAR-032551	Daucus carota carrot - (species)	Published - Accepted by Curator
DEEPER ROOTING 1	Drought tolerance Root growth	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Uga Y; Sugimoto K; Ogawa S ; et al. (2013) Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought condition[...]	GP00000215	Dro1 Q69P88	Physiology Morphology	1bp deletion within exon 4 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	DEEPER ROOTING 1	Oryza sativa rice - (species)	Published - Accepted by Curator
Delta-1-pyrroline-5-carboxylate synthase A	Drought response (drought-induced proline accumulation)	2 Mutations: Coding	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kesari R; Lasky JR; Villamor JG ; et al. (2012) Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation[...]	GP00001280	P5CSA P54887	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Delta-1-pyrroline-5-carboxylate synthase A	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
dentin sialophosphoprotein (DSPP)	Tooth absence (no enamel production)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001936	DSPP Q9NZW4	Physiology	synteny of the corresponding region - only the N-terminal region of DSPP is present in the genome - 1-bp deletion in exon one leading to a reading frame shift were this sequence to be translated N	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	dentin sialophosphoprotein (DSPP)	Gallus gallus chicken - (species)	Published - Accepted by Curator
DEP1	Grain yield	Coding, Indel N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Huang X; Qian Q; Liu Z ; et al. (2009) Natural variation at the DEP1 locus enhances grain yield in rice.	GP00000218	P0046G12.12-1 Q67UU9	Morphology	replacement of a 637bp stretch of the middle of exon5 by a 12-bp sequence creating a premature stop codon and consequently a loss of 230 residues from the C-terminus N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	DEP1	Oryza sativa rice - (species)	Published - Accepted by Curator
Dihydroflavonol 4 reductase (MlDfr)	Coloration (flower)	Coding, Insertion N	Erythranthe lewisii (species) D	Intraspecific	Candidate Gene	Wu CA; Streisfeld MA; Nutter LI ; et al. (2013) The genetic basis of a rare flower color polymorphism in Mimulus lewisii provides insight into the r[...]	GP00001457	DFRA P51102	Morphology	A 2 nt (TG) insertion at position 265 causing a frameshift and a greatly truncated protein of 106 aa only about one-fourth of its functional length N	Erythranthe lewisii (species)	Erythranthe lewisii (species) D	Dihydroflavonol 4 reductase (MlDfr)	Erythranthe lewisii (species)	Published - Accepted by Curator
DMRT3	Gait (ability to pace)	Coding, SNP N	Equus caballus horse - (species)	Domesticated	Linkage Mapping	Andersson LS; Larhammar M; Memic F ; et al. (2012) Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. 1 Additional References Petersen JL; Mickelson JR; Rendahl AK (2013) Genome-wide analysis reveals selection for important traits in domestic horse breeds.	GP00000230	DMRT3 F6W2R2	Behavior	g.22999655C>A p.S301* Premature stop codon (Ser301Stop) resulting in truncated protein: a single base change at nucleotide position chr23:22999655 causing a premature stop at codon 301 in DMRT3 (DMRT3_Ser301STOP). The allele is expected to encode a truncated protein lacking 1 N	Equus caballus horse - (species)	Equus caballus horse - (species)	DMRT3	Equus caballus horse - (species)	Published - Accepted by Curator
Dvl2	Organ size (tail)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Mansour TA; Lucot K; Konopelski SE ; et al. (2018) Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 [...]	GP00002110	DVL2 O14641	Morphology	single base deletion found on CFA 5(g.32195043_32195044del) that is homozygous in the three screw tail breeds - predicted to lead to a frameshift mutation and cause a premature stop codon that truncates the translated protein by 23 amino acids (p.Pro684LeufsX26) - 26 altered amino acids are predicted to be present in the highly conserved C-terminus of the mutant protein. N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D	Dvl2	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
dwarf-8 (d8)	Plant size (dwarfism)	Coding, Deletion N	Zea mays (species) D	Domesticated	Linkage Mapping	Peng J; Richards DE; Hartley NM ; et al. (1999) 'Green revolution' genes encode mutant gibberellin response modulators. 2 Additional References Camus-Kulandaivelu L; Veyrieras JB; Madur D (2006) Maize adaptation to temperate climate: relationship between population structure and polymorphism in[...] Thornsberry JM; Goodman MM; Doebley J (2001) Dwarf8 polymorphisms associate with variation in flowering time.	GP00000241	D8 Q9ST48	Morphology	330bp deletion to V84 N	Zea mays (species)	Zea mays (species) D	dwarf-8 (d8)	Zea mays (species)	Published - Accepted by Curator
EARLY FLOWERING 3 (here = Mat-a)	Flowering time	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Linkage Mapping	Zakhrabekova S; Gough SP; Braumann I ; et al. (2012) Induced mutations in circadian clock regulator Mat-a facilitated short-season adaptation and range e[...]	GP00000243	ELF3 O82804	Physiology	4bp deletion resulting in truncated protein ; this deletion seem to have evolved multiple times (fragile site?) N	Hordeum vulgare (species)	Hordeum vulgare (species) D	EARLY FLOWERING 3 (here = Mat-a)	Hordeum vulgare (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)	Flowering time (latitudinal adaptation)	Coding, Deletion N	Glycine max soybean - (species) D	Domesticated	Linkage Mapping	Lu S; Zhao X; Hu Y ; et al. (2017) Natural variation at the soybean J locus improves adaptation to the tropics and enhances yield.	GP00001683	CYP75B1 Q9SD85	Physiology	recessive allele responsible for the LJ trait - 10-bp deletion predicted to cause a frameshift resulting in premature termination of translation after 195 amino acids in the 714-amino-acid protein N	Glycine max soybean - (species)	Glycine max soybean - (species) D	EARLY FLOWERING 3(ELF3)	Glycine max soybean - (species)	Published - Accepted by Curator
EARLY FLOWERING 3/ EARLY MATURITY 8	Flowering time	Coding, SNP N	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Faure S; Turner AS; Gruszka D ; et al. (2012) Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]	GP00000245	ELF3 O82804	Physiology	Premature stop codon; C-to-T point mutation in exon 2 N	Hordeum vulgare (species)	Hordeum vulgare (species)	EARLY FLOWERING 3/ EARLY MATURITY 8	Hordeum vulgare (species)	Published - Accepted by Curator
EARLY FLOWERING 3/ EARLYMATURITY8	Flowering time	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Linkage Mapping	Faure S; Turner AS; Gruszka D ; et al. (2012) Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]	GP00000246	ELF3 O82804	Physiology	4bp deletion resulting in truncated protein ; this deletion seem to have evolved multiple times (fragile site?) N	Hordeum vulgare (species)	Hordeum vulgare (species) D	EARLY FLOWERING 3/ EARLYMATURITY8	Hordeum vulgare (species)	Published - Accepted by Curator
EDAR	Scales (reduced)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002359	EDAR Q9UNE0	Morphology	Several deletions in the EDAR1 coding region. N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	EDAR	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
EDAR	Scales (reduced)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002360	EDAR Q9UNE0	Morphology; Physiology	Deletion of a large part of the EDAR2 coding region. N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D	EDAR	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth absence (no enamel production)	Gene Loss, Deletion N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001935	ENAM Q9NRM1	Physiology	synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	enamelin (ENAM)	Gallus gallus chicken - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth absence (no enamel production)	Coding, Deletion N	Eubalaena glacialis North Atlantic right whale - (species) D Megaptera novaeangliae humpback whale - (species) D Eschrichtius robustus grey whale - (species) D Caperea marginata pygmy right whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001939	ENAM Q9NRM1	Physiology	1-bp deletion. Various frameshift mutations were found in the distinct species. N	Cetacea whales - (order)	Eubalaena glacialis North Atlantic right whale - (species) D Megaptera novaeangliae humpback whale - (species) D Eschrichtius robustus grey whale - (species) D Caperea marginata pygmy right whale - (species) D	enamelin (ENAM)	Eubalaena glacialis North Atlantic right whale - (species) Megaptera novaeangliae humpback whale - (species) Eschrichtius robustus grey whale - (species) Caperea marginata pygmy right whale - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	2 Mutations: Coding Deletion N	Kogia sima dwarf sperm whale - (species) D Kogia breviceps pygmy sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001942	ENAM Q9NRM1	Physiology	2 mutations	Physeter catodon sperm whale - (species)	Kogia sima dwarf sperm whale - (species) D Kogia breviceps pygmy sperm whale - (species) D	enamelin (ENAM)	Kogia sima dwarf sperm whale - (species) Kogia breviceps pygmy sperm whale - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	3 Mutations: Coding N	Orycteropus afer aardvark - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]	GP00001943	ENAM Q9NRM1	Physiology	3 mutations	Elephantulus rufescens East African long-eared elephant shrew - (species)	Orycteropus afer aardvark - (species) D	enamelin (ENAM)	Orycteropus afer aardvark - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	Coding, Unknown N	Manis pentadactyla Chinese pangolin - (species) D Manis tricuspis Tree pangolin - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]	GP00001944	ENAM Q9NRM1	Physiology	multiple deletions and insertions less than 9bp causing frameshift N	Canis lupus familiaris dog - (subspecies)	Manis pentadactyla Chinese pangolin - (species) D Manis tricuspis Tree pangolin - (species) D	enamelin (ENAM)	Manis pentadactyla Chinese pangolin - (species) Manis tricuspis Tree pangolin - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	Coding, Unknown N	Bradypus tridactylus Pale-throated sloth - (species) D Tamandua tetradactyla southern tamandua - (species) D Dasypus novemcinctus nine-banded armadillo - (species) D Euphractus sexcinctus (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]	GP00001945	ENAM Q9NRM1	Physiology	multiple frameshift insertions and deletions N	Canis lupus familiaris dog - (subspecies)	Bradypus tridactylus Pale-throated sloth - (species) D Tamandua tetradactyla southern tamandua - (species) D Dasypus novemcinctus nine-banded armadillo - (species) D Euphractus sexcinctus (species) D	enamelin (ENAM)	Bradypus tridactylus Pale-throated sloth - (species) Tamandua tetradactyla southern tamandua - (species) Dasypus novemcinctus nine-banded armadillo - (species) Euphractus sexcinctus (species)	Published - Accepted by Curator
enamelysin (MMP20)	Tooth absence (no enamel production)	Coding, Insertion N	Balaenoptera physalus Fin whale - (species) D Balaena mysticetus bowhead whale - (species) D Megaptera novaeangliae humpback whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001940	MMP20 O60882	Physiology	insertion of a CHR-2 SINE retroposon in exon 2 of MMP20 which would result in premature truncation of the MMP20 protein owing to stop codons in all possible reading frames of the CHR-2 SINE. The length of the MMP20 SINE ranges from 302 bp (B. musculus) to 318 bp (B. physalus). This mutation is found in eight investigated species of baleen whales. Other inactivating mutations (nonsense and frameshift mutations) are found in various species N	Physeter catodon sperm whale - (species)	Balaenoptera physalus Fin whale - (species) D Balaena mysticetus bowhead whale - (species) D Megaptera novaeangliae humpback whale - (species) D	enamelysin (MMP20)	Balaenoptera physalus Fin whale - (species) Balaena mysticetus bowhead whale - (species) Megaptera novaeangliae humpback whale - (species)	Published - Accepted by Curator
enamelysin (MMP20)	Tooth composition (no enamel production)	Coding, SNP N	Kogia breviceps pygmy sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001941	MMP20 O60882	Physiology	opal stop codon (TGA) in the propeptide-coding region of MMP20 exon 2 in a single individual of the pygmy sperm whale Kogia breviceps N	Kogia sima dwarf sperm whale - (species)	Kogia breviceps pygmy sperm whale - (species) D	enamelysin (MMP20)	Kogia breviceps pygmy sperm whale - (species)	Published - Accepted by Curator
Epithiospecifier protein (ESP)	Plant secondary metabolite (glucosinolate) Herbivore resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001) The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]	GP00000279	ESP Q8RY71	Physiology Physiology	deletion of 124 bases that eliminates a splice site and 100 nucleotides of the ORF N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Epithiospecifier protein (ESP)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000286	ERG3 P32353	Physiology	Arg63Stop A187T in line 21 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001744	ERG3 P32353	Physiology	Ser76Stop C227A in line 22 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001745	ERG3 P32353	Physiology	Ser95Stop C284A in line 23 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001746	ERG3 P32353	Physiology	Trp205Stop G615A in line 24 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001747	ERG3 P32353	Physiology	Trp205Stop G615A in line 25 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001748	ERG3 P32353	Physiology	Trp205Stop G615A in line 26 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001749	ERG3 P32353	Physiology	Trp205Stop G615A in line 27 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001750	ERG3 P32353	Physiology	29-bp duplication in line 28 at nucleotide position 641 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001751	ERG3 P32353	Physiology	Trp219Stop G656A in line 29 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001752	ERG3 P32353	Physiology	Gly235Ser G703A in line 30 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001753	ERG3 P32353	Physiology	Tyr299Stop C897A in line 31 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001754	ERG3 P32353	Physiology	Gly300Arg G898C in line 32 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001755	ERG3 P32353	Physiology	Asp307Ala A920C in line 33 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001756	ERG3 P32353	Physiology	1-bp deletion in line 34 A980- N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001757	ERG3 P32353	Physiology	60-bp deletion at position 253 in line 35 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG5	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000287	ERG5 P54781	Physiology	60bp deletion N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	ERG5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
FAD2 (BnaA.FAD2.a)	Oil composition Oil yield	Coding, Insertion N	Brassica napus rape - (species) D	Domesticated	Linkage Mapping	Yang Q; Fan C; Guo Z ; et al. (2012) Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific ma[...]	GP00000302	FAD2 P46313	Physiology Physiology	4bp insertion resulting in frameshift and premature stop codon N	Brassica napus rape - (species)	Brassica napus rape - (species) D	FAD2 (BnaA.FAD2.a)	Brassica napus rape - (species)	Published - Accepted by Curator
FAD2A	Oil composition (oleate levels)	Coding, SNP N	Arachis hypogaea peanut - (species) D	Domesticated	Candidate Gene	Jung S; Powell G; Moore K ; et al. (2000) The high oleate trait in the cultivated peanut [Arachis hypogaea L]. II. Molecular basis and genetic[...]	GP00002075	FAD2A E2GJC1	Physiology	D150N in a residue that is absolutely conserved among other desaturases N	Arachis hypogaea peanut - (species)	Arachis hypogaea peanut - (species) D	FAD2A	Arachis hypogaea peanut - (species)	Published - Accepted by Curator
FAD2B	Oil composition (oleate levels)	Coding, Insertion N	Arachis hypogaea peanut - (species) D	Domesticated	Candidate Gene	Patel M; Jung S; Moore K ; et al. (2004) High-oleate peanut mutants result from a MITE insertion into the FAD2 gene.	GP00002073	FAD2B Q9LKK6	Physiology	insertion of 205-bp miniature inverted-repeat transposable element (MITE) called ahMITE1 at position 665 near the center of the coding region in the case of MF; which causes a frameshift N	Arachis hypogaea peanut - (species)	Arachis hypogaea peanut - (species) D	FAD2B	Arachis hypogaea peanut - (species)	Published - Accepted by Curator
FAD2B	Oil composition (oleate levels)	Coding, Insertion N	Arachis hypogaea peanut - (species) D	Domesticated	Candidate Gene	Patel M; Jung S; Moore K ; et al. (2004) High-oleate peanut mutants result from a MITE insertion into the FAD2 gene.	GP00002074	FAD2B Q9LKK6	Physiology	insertion of 205-bp miniature inverted-repeat transposable element (MITE) called ahMITE1 at position 997 of the coding region; which causes a frameshift N	Arachis hypogaea peanut - (species)	Arachis hypogaea peanut - (species) D	FAD2B	Arachis hypogaea peanut - (species)	Published - Accepted by Curator
FGF20	Organ loss (feathers ; scales)	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Wells KL; Hadad Y; Ben-Avraham D ; et al. (2012) Genome-wide SNP scan of pooled DNA reveals nonsense mutation in FGF20 in the scaleless line of feath[...]	GP00002171	FGF20 Q9NP95	Morphology	g.62878803A>T c.535A>T p.R179* N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D	FGF20	Gallus gallus chicken - (species)	Published - Accepted by Curator
FGF5	Hair length (length)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Drögemüller C; Rüfenacht S; Wichert B ; et al. (2007) Mutations within the FGF5 gene are associated with hair length in cats. 1 Additional References Kehler JS; David VA; Schäffer AA (2007 Sep-Oct) Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired p[...]	GP00000311	Fgf5 P15656	Morphology	c.474delT resulting in frameshift N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	FGF5	Felis catus domestic cat - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Legrand R; Tiret L; Abitbol M (2014) Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys.	GP00001369	Fgf5 P15656	Morphology	c.433_434delAT frameshift deletion leading to a stop codon at position 159 N	Equus asinus ass - (species)	Equus asinus ass - (species) D	FGF5	Equus asinus ass - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP N	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Legrand R; Tiret L; Abitbol M (2014) Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys.	GP00001370	Fgf5 P15656	Morphology	c.245G>A p.W82* nonsense mutation leading to stop codon at position 82 N	Equus asinus ass - (species)	Equus asinus ass - (species) D	FGF5	Equus asinus ass - (species)	Published - Accepted by Curator
FGF5	Hair length (length)	Coding, Insertion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Drögemüller C; Rüfenacht S; Wichert B ; et al. (2007) Mutations within the FGF5 gene are associated with hair length in cats. 1 Additional References Kehler JS; David VA; Schäffer AA (2007 Sep-Oct) Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired p[...]	GP00002172	Fgf5 P15656	Morphology	c.ins356T resulting in frameshift N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	FGF5	Felis catus domestic cat - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mesocricetus auratus golden hamster - (species) D	Domesticated	Candidate Gene	Yoshizawa Y; Wada K; Shimoi G ; et al. (2015) A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster.	GP00002173	Fgf5 P15656	Morphology	c.546delG p.Arg184GlyfsX6 N	Mesocricetus auratus golden hamster - (species)	Mesocricetus auratus golden hamster - (species) D	FGF5	Mesocricetus auratus golden hamster - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP N	Cavia porcellus domestic guinea pig - (species) D	Domesticated	Candidate Gene	Yu F; Liu Z; Jiao S ; et al. (2018) A nonsense mutation in the FGF5 gene is associated with the long-haired phenotype in domestic guinea[...]	GP00002178	Fgf5 P15656	Morphology	c.403C>T p.Arg135* N	Cavia porcellus domestic guinea pig - (species)	Cavia porcellus domestic guinea pig - (species) D	FGF5	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Indel N	Lama glama llama - (species) D	Domesticated	Candidate Gene	Daverio MS; Vidal-Rioja L; Frank EN ; et al. (2017) Molecular characterization of the llama FGF5 gene and identification of putative loss of function mu[...]	GP00002179	Fgf5 P15656	Morphology	a single base deletion (c.348delA) + a 12-bp insertion (c.351_352insCATATAACATAG) N	Lama guanicoe guanaco - (species)	Lama glama llama - (species) D	FGF5	Lama glama llama - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP N	Lama glama llama - (species) D Vicugna pacos alpaca - (species) D	Domesticated	Candidate Gene	Daverio MS; Vidal-Rioja L; Frank EN ; et al. (2017) Molecular characterization of the llama FGF5 gene and identification of putative loss of function mu[...] 2 Additional References Pallotti S; Pediconi D; Subramanian D (2018) Evidence of post-transcriptional readthrough regulation in FGF5 gene of alpaca. Fan R; Gu Z; Guang X (2020) Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca.	GP00002180	Fgf5 P15656	Morphology	transition C>T at position 499 downstream of the ATG codon with transcriptional readthrough ; difference in post-transcriptional readthrough may underlie the different fleece types of the alpaca suri and huacaya breeds ; derived allele was introgressed from lamas to alpacas N	Lama guanicoe guanaco - (species)	Lama glama llama - (species) D Vicugna pacos alpaca - (species) D	FGF5	Lama glama llama - (species) Vicugna pacos alpaca - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Hébert JM; Rosenquist T; Götz J ; et al. (1994) FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. 1 Additional References Sundberg JP; Rourk MH; Boggess D (1997) Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin graf[...]	GP00002441	Fgf5 P15656	Morphology	Deletion which extends at least 2kb upstream of the Fgf5 translational start site and terminates at the end of the first exon or beginning of the first intron. N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	FGF5	Mus musculus house mouse - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Mizuno S; Iijima S; Okano T ; et al. (2011) Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.	GP00002442	Fgf5 P15656	Morphology	Deletion of a 9.3-kb region in the Fgf5 gene including exon 3 and its 5' and 3' flanking sequences. The genomic deletion site also shows insertion of a 498-bp early transposon element long terminal repeat. N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	FGF5	Mus musculus house mouse - (species)	Published - Accepted by Curator
Fgfr1a1	Scales (loss)	Coding, Deletion N	Cyprinus carpio common carp - (species) D	Domesticated	Candidate Gene	Rohner N; Bercsényi M; Orbán L ; et al. (2009) Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication.	GP00000312	fgfr1a Q90Z00	Morphology	deletion of 310 bp N	Cyprinus carpio common carp - (species)	Cyprinus carpio common carp - (species) D	Fgfr1a1	Cyprinus carpio common carp - (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000315	CYP75B1 Q9SD85	Morphology	-1bp at +973 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D	Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000316	CYP75B1 Q9SD85	Morphology	-1bp at +1164 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D	Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Zufall RA; Rausher MD (2003 Nov-Dec) The genetic basis of a flower color polymorphism in the common morning glory (Ipomoea purpurea). 3 Additional References Hoshino A; Morita Y; Choi JD (2003) Spontaneous mutations of the flavonoid 3'-hydroxylase gene conferring reddish flowers in the three m[...] Zufall RA; Rausher MD (2004) Genetic changes associated with floral adaptation restrict future evolutionary potential. Des Marais DL; Rausher MD (2010) Parallel evolution at multiple levels in the origin of hummingbird pollinated flowers in Ipomoea.	GP00000319	CYP75B1 Q9SD85	Morphology	insertion of the 0.55-kb DNA transposable element Tip201 belonging to the Ac/Ds superfamily. No excision of Tip201 from the F3'H gene could be detected. Both splicing and polyadenylation patterns of the F3'H transcripts were affected by the Tip201 integration. N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D	flavonoid 3'-hydroxylase (F3'H)	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (seed; pods)	Coding, Deletion N	Glycine max soybean - (species) D	Domesticated	Linkage Mapping	Toda K; Yang D; Yamanaka N ; et al. (2002) A single-base deletion in soybean flavonoid 3'-hydroxylase gene is associated with gray pubescence c[...] 1 Additional References Zabala G; Vodkin L (2003) Cloning of the pleiotropic T locus in soybean and two recessive alleles that differentially affect s[...]	GP00000321	CYP75B1 Q9SD85	Morphology	1bp deletion resulting in frameshift N	Glycine max soybean - (species)	Glycine max soybean - (species) D	flavonoid 3'-hydroxylase (F3'H)	Glycine max soybean - (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers)	Coding, SNP N	Ipomoea nil Japanese morning glory - (species) D	Domesticated	Candidate Gene	Hoshino A; Morita Y; Choi JD ; et al. (2003) Spontaneous mutations of the flavonoid 3'-hydroxylase gene conferring reddish flowers in the three m[...]	GP00002087	CYP75B1 Q9SD85	Morphology	nonsense mutation caused by a single C to T base transition generating the stop codon TGA. N	Ipomoea nil Japanese morning glory - (species)	Ipomoea nil Japanese morning glory - (species) D	flavonoid 3'-hydroxylase (F3'H)	Ipomoea nil Japanese morning glory - (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers)	Coding, Insertion N	Ipomoea tricolor (species) D	Domesticated	Candidate Gene	Hoshino A; Morita Y; Choi JD ; et al. (2003) Spontaneous mutations of the flavonoid 3'-hydroxylase gene conferring reddish flowers in the three m[...]	GP00002088	CYP75B1 Q9SD85	Morphology	a single T insertion generating the stop codon TAG. The accumulation of the F3'H transcripts is drastically reduced by the nonsense-mediated RNA decay. N	Ipomoea tricolor (species)	Ipomoea tricolor (species) D	flavonoid 3'-hydroxylase (F3'H)	Ipomoea tricolor (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers; pubescence; seeds)	Coding, Insertion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000322	CYP75A2 P37120	Morphology	53bp insertion at +1352 N	Glycine max soybean - (species)	Glycine soja (species) D	flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Gene Loss, Complex Change N	Iochroma cyaneum (species)	Interspecific	Linkage Mapping	Smith SD; Rausher MD (2011) Gene loss and parallel evolution contribute to species difference in flower color.	GP00000324	CYP75A2 P37120	Morphology	Large deletion N	Iochroma cyaneum (species)	Iochroma cyaneum (species)	flavonoid 3';5'-hydroxylase (F3'5'H)	Iochroma cyaneum (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, Deletion N	Pisum sativum pea - (species) D	Domesticated	Linkage Mapping	Moreau C; Ambrose MJ; Turner L ; et al. (2012) The B gene of pea encodes a defective flavonoid 3',5'-hydroxylase, and confers pink flower color.	GP00000327	CYP75A2 P37120	Morphology	23bp deletion reuslting in frameshift and truncated protein N	Pisum sativum pea - (species)	Pisum sativum pea - (species) D	flavonoid 3';5'-hydroxylase (F3'5'H)	Pisum sativum pea - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000330	FLC Q9S7Q7	Physiology	Substitution creating premature Stop (codon 158) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC-2	Flowering time	Coding, Deletion N	Brassica oleracea wild cabbage - (species) D	Domesticated	Linkage Mapping	Okazaki K; Sakamoto K; Kikuchi R ; et al. (2007) Mapping and characterization of FLC homologs and QTL analysis of flowering time in Brassica oleracea[...]	GP00000339	FLC Q9S7Q7	Physiology	1bp deletion resulting in frameshift N	Brassica oleracea wild cabbage - (species)	Brassica oleracea wild cabbage - (species) D	FLC-2	Brassica oleracea wild cabbage - (species)	Published - Accepted by Curator
FLM (MAF1)	Flowering time	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Warthmann N ; et al. (2005) Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for[...]	GP00000341	AGL27 Q9AT76	Physiology	Deletion of entire gene N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLM (MAF1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Flowering locus T (FT1)	Flowering time	Coding, Deletion N	Helianthus annuus common sunflower - (species) D	Domesticated	Linkage Mapping	Blackman BK; Strasburg JL; Raduski AR ; et al. (2010) The role of recently derived FT paralogs in sunflower domestication.	GP00000346	FT Q9SXZ2	Physiology	1bp deletion; frameshift N	Helianthus annuus common sunflower - (species)	Helianthus annuus common sunflower - (species) D	Flowering locus T (FT1)	Helianthus annuus common sunflower - (species)	Published - Accepted by Curator
FOXI3	Hair (hypotrichosis)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Drögemüller C; Karlsson EK; Hytönen MK ; et al. (2008) A mutation in hairless dogs implicates FOXI3 in ectodermal development.	GP00000351	FOXI3 B5RHS5	Morphology	Frameshift; 7-bp duplication within exon 1 N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	FOXI3	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FPN2	Metal tolerance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Morrissey J; Baxter IR; Lee J ; et al. (2009) The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.	GP00000354	IREG2 F4KGN5	Physiology	1bp insertion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	FPN2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]	GP00000357	FRI P0DH90	Physiology	16bp deletion aa313-318 in exon 2 and premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000358	FRI P0DH90	Physiology	376 bp deletion and 31 bp insertion that delete amino acid 1-15 and at best produce a 45-aa protein N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000359	FRI P0DH90	Physiology	Del 2257-2355 in exon 3; deletion of 99 bp combined with an insertion of 61 bp N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000360	FRI P0DH90	Physiology	1bp deletion at 1487 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000361	FRI P0DH90	Physiology	1bp insertion at 766 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000362	FRI P0DH90	Physiology	Insertion 1 bp at 1454 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000363	FRI P0DH90	Physiology	Trp240* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000364	FRI P0DH90	Physiology	Glu361* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gazzani S; Gendall AR; Lister C ; et al. (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.	GP00000365	FRI P0DH90	Physiology	K232* in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000366	FRI P0DH90	Physiology	deletion; E430* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000369	FRI P0DH90	Physiology	deletion resulting in S121* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000370	FRI P0DH90	Physiology	deletion; AF375-6* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000371	FRI P0DH90	Physiology	insertion; I490* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000372	FRI P0DH90	Physiology	insertion; T258* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000373	FRI P0DH90	Physiology	Y162* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000374	FRI P0DH90	Physiology	K170* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 1 (FRL1)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000376	FRL1 Q9FFF1	Physiology	E279* in the middle of the conceptual protein sequence N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida like 1 (FRL1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...]	GP00000379	FUT2 Q10981	Physiology	9.3 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 2 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...] Koda Y; Soejima M; Johnson PH (2000) An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype.	GP00000380	FUT2 Q10981	Physiology	10 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000381	FUT2 Q10981	Physiology	premature stop at codon 143: TGG>TGA N	Homo sapiens human - (species)	Homo sapiens human - (species)	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
gastrin	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001914	GAST P01350	Physiology	Absence of the gene in the genome sequence - high synteny N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	gastrin	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Gene Loss, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001238	GL1 P27900	Morphology	gene loss: -4.7KB at position -948bp N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001240	GL1 P27900	Morphology	+1bp at position 352 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001241	GL1 P27900	Morphology	-1bp at position 203 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
glb-5	CO2 avoidance Aggregation behavior	Coding, Indel N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	McGrath PT; Rockman MV; Zimmer M ; et al. (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] 2 Additional References Bendesky A; Pitts J; Rockman MV (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...] Persson A; Gross E; Laurent P (2009) Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.	GP00000399	glb-5 A3RMS5	Behavior Behavior	765bp insertion/duplication resulting in a truncation of the last 179 amino acids of the protein and the inclusion of 40 different residues N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	glb-5	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLC-1	Xenobiotic resistance (antihelmintics)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Ghosh R; Andersen EC; Shapiro JA ; et al. (2012) Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.	GP00000400	glc-1 G5EBR3	Physiology	4aa deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	GLC-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLO(T)	Flower morphology (anther elevation)	Coding, Insertion N	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001393	GLO Q03378	Morphology	A 2.5 kb retrotransposon in exon 2 severely truncates the protein N	Primula vulgaris (species)	Primula vulgaris (species) D	GLO(T)	Primula vulgaris (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001671	GPRC6A Q5T6X5	Physiology	KGRKLP>KGK--Y in the third intracellular loop (ICL3) responsible for the intracellular retention and lack of function N	Homo sapiens human - (species)	Homo sapiens human - (species) D	GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001672	GPRC6A Q5T6X5	Physiology	C>T (aa57) located in the first exon resulting in a premature Stop-codon and non-functional protein N	Homo sapiens human - (species)	Homo sapiens human - (species) D	GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002354	opn1mw1 Q9W6A5	Physiology	Rh2-1 coding sequence absent from the full genome sequence of the three Sinocyclocheilus species N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Green-sensitive opsin (RH2)	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002355	opn1mw4 Q9W6A6	Physiology	Rh2-4 coding sequence absent from the full genome sequence of S. anshuiensis but present in the genome of Sinocyclocheilus rhinocerous and S. grahami N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D	Green-sensitive opsin (RH2)	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002356	opn1mw2 Q8AYM8	Physiology	Rh2-2 coding sequence absent from the full genome sequence of the three Sinocyclocheilus species N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Green-sensitive opsin (RH2)	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
Growth Hormone Receptor (GHR)	Body size (height)	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000415	GHR P10912	Morphology	Arg61* N	Homo sapiens human - (species)	Homo sapiens human - (species)	Growth Hormone Receptor (GHR)	Homo sapiens human - (species)	Published - Accepted by Curator
Growth Hormone Receptor (GHR)	Body size (dwarfism)	Coding, Deletion N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Agarwal SK; Cogburn LA; Burnside J (1994) Dysfunctional growth hormone receptor in a strain of sex-linked dwarf chicken: evidence for a mutati[...]	GP00002189	GHR P10912	Morphology	deletion of 1773 bp in the 3' end of the coding region N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D	Growth Hormone Receptor (GHR)	Gallus gallus chicken - (species)	Published - Accepted by Curator
GS3	Grain size	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Fan C; Xing Y; Mao H ; et al. (2006) GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, en[...] 1 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000417	GS3 C6L686	Morphology	C55*;TGC>TGA causing a 178-aa truncation in the C-terminus of the predicted protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species)	GS3	Oryza sativa rice - (species)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000420	Gulo P58710	Physiology	pseudogenization involving invalidating mutations at most exons N	Mammalia mammals - (class)	Cavia porcellus domestic guinea pig - (species)	Gulo	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Myotis lucifugus little brown bat - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000421	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Myotis lucifugus little brown bat - (species)	Gulo	Myotis lucifugus little brown bat - (species)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Primates (order)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000422	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Primates (order)	Gulo	Primates (order)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Pteropus vampyrus large flying fox - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000423	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Pteropus vampyrus large flying fox - (species)	Gulo	Pteropus vampyrus large flying fox - (species)	Published - Accepted by Curator
GW2	Grain size	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Song XJ; Huang W; Shi M ; et al. (2007) A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase.	GP00000424	GW2 A4GWX9	Morphology	1bp deletion resulting in a premature stop codon in exon 4; the premature stop codon led to truncation of 310 amino acid residues N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	GW2	Oryza sativa rice - (species)	Published - Accepted by Curator
GW2	Grain size	Coding, Insertion N	Triticum aestivum bread wheat - (species) D	Domesticated	Linkage Mapping	Yang Z; Bai Z; Li X ; et al. (2012) SNP identification and allelic-specific PCR markers development for TaGW2, a gene linked to wheat ke[...]	GP00000425	GW2 A4GWX9	Morphology	1bp insertion resulting in premature stop codon N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species) D	GW2	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000426	ABCA2 A0A0S0G7V0	Physiology	Pro53* (161T>A) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...] 2 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000427	ABCA2 A0A0S0G7V0	Physiology	10kb deletion N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000428	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000429	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000430	ABCA2 A0A0S0G7V0	Physiology	Insertion of an incomplete RNA transposon (1498bp) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000431	ABCA2 A0A0S0G7V0	Physiology	Insertion of a DNA transposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000432	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000433	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
HAC1 (=ATQ1)	Xenobiotic resistance (soil contamination; arsenate)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Chen Y; Chen J ; et al. (2014) Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]	GP00000435	HAC1 Q9C5X9	Physiology	1bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	HAC1 (=ATQ1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Doi K; Izawa T; Fuse T ; et al. (2004) Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-[...]	GP00000439	HD1 Q9FDX8	Physiology	Retro-element-like inserted in exon 2 N	Oryza glaberrima African rice - (species)	Oryza sativa rice - (species) D	Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Yano M; Katayose Y; Ashikari M ; et al. (2000) Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Ara[...] 1 Additional References Takahashi Y; Teshima KM; Yokoi S (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00000441	HD1 Q9FDX8	Physiology	2bp deletion in the putative exon 2 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001722	HD1 Q9FDX8	Physiology	1bp deletion at position 606 ; presumptive protein truncated N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001723	HD1 Q9FDX8	Physiology	1bp deletion at position 321 ; presumptive protein truncated N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001724	HD1 Q9FDX8	Physiology	4bp deletion at position 1089 ; presumptive protein truncated N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001725	HD1 Q9FDX8	Physiology	C to T – stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd6a	Flowering time	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Takahashi Y; Shomura A; Sasaki T ; et al. (2001) Hd6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the alpha subunit [...]	GP00000442	HD6 Q9AR27	Physiology	K91*; AAG>TAG N	Oryza sativa rice - (species)	Oryza sativa rice - (species)	Hd6a	Oryza sativa rice - (species)	Published - Accepted by Curator
HEADING DATE 1	Flowering time (latitudinal adaptation)	Cis-regulatory, Insertion N	Oryza sativa Japonica Group Japanese rice - (no rank) D	Domesticated	Candidate Gene	Goretti D; Martignago D; Landini M ; et al. (2017) Transcriptional and Post-transcriptional Mechanisms Limit Heading Date 1 (Hd1) Function to Adapt Ric[...]	GP00001674	HD1 Q9FDX8	Physiology	Hd1(EH) allele with a 4.4 kb mobile element inserted at position -166pb that suppressed gene transcription N	Oryza sativa rice - (species)	Oryza sativa Japonica Group Japanese rice - (no rank) D	HEADING DATE 1	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, Deletion N	Sorghum virgatum (species) D	Domesticated	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001408	CO Q39057	Physiology	5bp deletion in the coding sequence leading to gene frameshift N	Sorghum bicolor sorghum - (species)	Sorghum virgatum (species) D	Heading Date 1 (HD1)	Sorghum virgatum (species)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, Deletion N	Sorghum (genus) D	Interspecific	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001409	CO Q39057	Physiology	80bp deletion in first exon leading to gene frameshift N	Sorghum (genus)	Sorghum (genus) D	Heading Date 1 (HD1)	Sorghum (genus)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, SNP N	Setaria italica foxtail millet - (species) D	Domesticated	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001410	CO Q39057	Physiology	splicing variant at position 787 GT>AT resulting in a splicing shift to position 754 introducing a deletion of 33 bp in the transcript and 11 aa in the protein N	Setaria italica foxtail millet - (species)	Setaria italica foxtail millet - (species) D	Heading Date 1 (HD1)	Setaria italica foxtail millet - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000444	HMA3 P0CW78	Physiology	1-bp deletion resulting in a premature stop codon resulting in hypofunctional transporter. This is a high-frequency allele; suggesting the hyper-functional alleles are only selected in Cd-rich soils N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HM1 = HC toxin reductase (HCTR) [possible pseudo-replicate from other Maize entry]	Pathogen resistance	Coding, Insertion N	Zea mays (species) D	Domesticated	Linkage Mapping	Johal GS; Briggs SP (1992) Reductase activity encoded by the HM1 disease resistance gene in maize. 1 Additional References Multani DS; Meeley RB; Paterson AH (1998) Plant-pathogen microevolution: molecular basis for the origin of a fungal disease in maize.	GP00000481	hm1 O49163	Physiology	256-bp transposable element insertion in exon 4 N	Zea mays (species)	Zea mays (species) D	HM1 = HC toxin reductase (HCTR) [possible pseudo-replicate from other Maize entry]	Zea mays (species)	Published - Accepted by Curator
HM2 = HC toxin reductase (HCTR)	Pathogen resistance	Coding, Deletion N	Zea mays (species) D	Domesticated	Candidate Gene	Chintamanani S; Multani DS; Ruess H ; et al. (2008) Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred b[...]	GP00000482	hm2 B8QWA3	Physiology	deletion from exon 2 (nucleotide 420) to beyond the confines of the hm2 gene into an unknown genomic region. N	Zea mays (species)	Zea mays (species) D	HM2 = HC toxin reductase (HCTR)	Zea mays (species)	Published - Accepted by Curator
HM2 = HC toxin reductase (HCTR)	Pathogen resistance	Coding, Insertion N	Zea mays (species) D	Domesticated	Candidate Gene	Chintamanani S; Multani DS; Ruess H ; et al. (2008) Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred b[...]	GP00000483	hm2 B8QWA3	Physiology	8-bp insertion in exon 1 that disrupt the reading frame and introduces a stop codon shortly after the beginning of the gene N	Zea mays (species)	Zea mays (species) D	HM2 = HC toxin reductase (HCTR)	Zea mays (species)	Published - Accepted by Curator
HMGA2	Body size (dwarfism) Cranio-facial morphology	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Association Mapping	Carneiro M; Hu D; Archer J ; et al. (2017) Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA[...]	GP00001675	HMGA2 P52926	Morphology Morphology	deletion of 12.1 kb overlapping the promoter region and first three exons leading to inactivation of the gene. The 5'-end of this deletion overlaps a CSINE2 element N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	HMGA2	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
Hox gene cluster	Body plan (number of segments)	Gene Loss, Deletion N	Hypsibius dujardini (species) D Paramacrobiotus richtersi (species) D Milnesium tardigradum (species) D	Intergeneric or Higher	Candidate Gene	Smith FW; Boothby TC; Giovannini I ; et al. (2016) The Compact Body Plan of Tardigrades Evolved by the Loss of a Large Body Region.	GP00001946	Antp P02833	Morphology	The three genes Antp Ubx AbdA are missing in the genome sequences of the three tardigrades. This loss is ancient so difficult to evaluate whether the three genes were lost due to a single mutational event or due to successive mutations. The Hox cluster is disorganized in the H. dujardini genome. N	Drosophila melanogaster fruit fly - (species)	Hypsibius dujardini (species) D Paramacrobiotus richtersi (species) D Milnesium tardigradum (species) D	Hox gene cluster	Hypsibius dujardini (species) Paramacrobiotus richtersi (species) Milnesium tardigradum (species)	Published - Accepted by Curator
HP1D2	Sex determination (sex ratio distortion)	Coding, Deletion N	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Helleu Q; Gérard PR; Dubruille R ; et al. (2016) Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.	GP00001467	HP1D2 B4R6K0	Physiology	deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N	Drosophila simulans (species)	Drosophila simulans (species) D	HP1D2	Drosophila simulans (species)	Published - Accepted by Curator
Hps4	Coloration (albinism)	Coding, Deletion N	Ictalurus punctatus channel catfish - (species) D	Intraspecific	Association Mapping	Li Y; Geng X; Bao L ; et al. (2017) A deletion in the Hermansky-Pudlak syndrome 4 (Hps4) gene appears to be responsible for albinism in [...]	GP00002122	Hps4 Q99KG7	Morphology	A 99‐bp deletion was identified spanning intron 2 and exon 3 junction of the Hps4 gene N	Ictalurus punctatus channel catfish - (species)	Ictalurus punctatus channel catfish - (species) D	Hps4	Ictalurus punctatus channel catfish - (species)	Published - Accepted by Curator
Hs1 = pro-1	Pathogen resistance (parasite, nematodes) (nematodes)	Gene Loss, Complex Change N	Beta vulgaris (species)	Domesticated	Linkage Mapping	Cai D; Kleine M; Kifle S ; et al. (1997) Positional cloning of a gene for nematode resistance in sugar beet.	GP00000490	HSPRO1 Q9LY61	Physiology	cDNA sequence lacking in genomic DNA N	Patellifolia (genus)	Beta vulgaris (species)	Hs1 = pro-1	Beta vulgaris (species)	Published - Accepted by Curator
HUA2	Flowering time Shoot morphology	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Wang Q; Sajja U; Rosloski S ; et al. (2007) HUA2 caused natural variation in shoot morphology of A. thaliana.	GP00000491	HUA2 Q9XER9	Physiology Morphology	K525E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HUA2	Flowering time Coloration (temperature-dependent)	Coding, Unknown N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ilk N; Ding J; Ihnatowicz A ; et al. (2015) Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...] 1 Additional References Doyle MR; Bizzell CM; Keller MR (2005) HUA2 is required for the expression of floral repressors in Arabidopsis thaliana.	GP00001230	HUA2 Q9XER9	Physiology Morphology	Premature stop codon resulting in truncation of 290 C-terminal amino-acids (hua-2-5 Ler allele) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HvbHLH1	Coloration	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Association Mapping	Cockram J; White J; Zuluaga DL ; et al. (2010) Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genom[...]	GP00000493	bHLH1 E5FCX3	Morphology	16bp deletion resulting in premature stop codon N	Hordeum vulgare (species)	Hordeum vulgare (species) D	HvbHLH1	Hordeum vulgare (species)	Published - Accepted by Curator
ICARUS1	Plant growth (leaf morphology ; temperature-dependent) Hypersensitive to DNA damage	2 Mutations: Coding N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Zhu W; Ausin I; Seleznev A ; et al. (2015) Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at[...]	GP00002066	ICA1 A0A0F7PXK5	Physiology Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	ICARUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Indian hedgehog (IHH)	Limb size (legs)	Gene Loss, Deletion N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Jin S; Zhu F; Wang Y ; et al. (2016) Deletion of Indian hedgehog gene causes dominant semi-lethal Creeper trait in chicken.	GP00002194	IHH Q98938	Morphology	11,896 bp large deletion region (chr7: 21,798,705-21,810,600) covering the entire Indian hedgehog (IHH) gene N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D	Indian hedgehog (IHH)	Gallus gallus chicken - (species)	Published - Accepted by Curator
KCS18	Oil composition	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jasinski S; Lécureuil A; Miquel M ; et al. (2012) Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]	GP00000512	FAE1 Q38860	Physiology	L407V N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	KCS18	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Kit	Coloration (coat ; white-spotting)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Wong AK; Ruhe AL; Robertson KR ; et al. (2013) A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs.	GP00002228	Kit P05532	Morphology	a 1-bp insertion of an adenine 70 bases downstream of the beginning of exon 2 resulting in frameshift N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	Kit	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP N	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00000516	Kit P05532	Morphology	c.2151C>G pY717* N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00002198	Kit P05532	Morphology	c.706A>T p.K236* N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002202	Kit P05532	Morphology	c.1126_1129delGAAC p.E376FfsX3 N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002205	Kit P05532	Morphology	c.2193delG p.T732QfsX9 N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002212	Kit P05532	Morphology	c.2392_2445del p.H798_N815del N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Jagannathan V; Rieder S ; et al. (2015) A novel KIT variant in an Icelandic horse with white-spotted coat colour.	GP00002216	Kit P05532	Morphology	c.2369delC p.Ala790Glufs*20 N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Dürig N; Jude R; Holl H ; et al. (2017) Whole genome sequencing reveals a novel deletion variant in the KIT gene in horses with white spotte[...]	GP00002219	Kit P05532	Morphology	g.77;740;239_77;742;136del1898insTATAT ~1.9-kb deletion N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hug P; Jude R; Henkel J ; et al. (2019) A novel KIT deletion variant in a German Riding Pony with white-spotting coat colour phenotype.	GP00002223	Kit P05532	Morphology	g.79;579;925-79;581;197del 1273bp deletion N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat ; white-spotting)	Coding, Deletion N	Camelus dromedarius Arabian camel - (species) D	Domesticated	Candidate Gene	Holl H; Isaza R; Mohamoud Y ; et al. (2017) A Frameshift Mutation in KIT is Associated with White Spotting in the Arabian Camel.	GP00002229	Kit P05532	Morphology	c.1842delG p.M614IfsX5 N	Camelus dromedarius Arabian camel - (species)	Camelus dromedarius Arabian camel - (species) D	Kit (type III receptor protein-tyrosine kinase)	Camelus dromedarius Arabian camel - (species)	Published - Accepted by Curator
Kit ligand	Coloration (coat)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Seitz JJ; Schmutz SM; Thue TD ; et al. (1999) A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and[...] 1 Additional References Aasland M; Klungland H; Lien S (2000) Two polymorphisms in the bovine mast cell growth factor gene (MGF).	GP00000101	KITLG P21583	Morphology	Ala193Asp ; missense mutation at position 654 - according to OMIA: c.572C>A p.A191N N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Kit ligand	Bos taurus cattle - (species)	Published - Accepted by Curator
KRT71	Hair type (curly and hairless)	Coding, Deletion N	Rattus norvegicus Norway rat - (species) D	Domesticated	Linkage Mapping	Kuramoto T; Hirano R; Kuwamura M ; et al. (2010) Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gen[...]	GP00001729	Krt71 Q9R0H5	Morphology	a 7-bp deletion at the splicing acceptor site of intron 1. The deletion provoked a 6-amino acid in-frame deletion (p.Val149_Gln154del) in the alpha-helical rod domain of KRT71 protein N	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D	KRT71	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
KRT71	Hair type (curly and hairless)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Association Mapping	Gandolfi B; Outerbridge CA; Beresford LG ; et al. (2010) The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.	GP00001730	Krt71 Q9R0H5	Morphology	eight base pair deletion mutation in exon one of the keratin 71 (KRT71) c.334delTGTGCCCA p.Met93AsnfsX14 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	KRT71	Bos taurus cattle - (species)	Published - Accepted by Curator
KRT71	Hair type (curly)	Coding, SNP N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Gandolfi B; Alhaddad H; Joslin SE ; et al. (2013) A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats.	GP00002232	Krt71 Q9R0H5	Morphology	c.445-1G>C in splice site likely disrupts the highly conserved acceptor splicing site of intron one. Sequence of the complete RNA transcript revealed that an alternative downstream acceptor was employed N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	KRT71	Felis catus domestic cat - (species)	Published - Accepted by Curator
L6	Pathogen resistance	Coding, Insertion N	Linum usitatissimum flax - (species)	Intraspecific	Linkage Mapping	Lawrence GJ; Finnegan EJ; Ayliffe MA ; et al. (1995) The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 an[...]	GP00000528	L6 Q40253	Physiology	Truncated protein due to insertion of a transposable element. Reversion to resistance among descendants of mutant X75 was associated with excision of the newly transposable element Ac. N	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species)	L6	Linum usitatissimum flax - (species)	Published - Accepted by Curator
lanosterol c14 demethylase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intergeneric or Higher	Candidate Gene	Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001951	CYP51A1 Q16850	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Caenorhabditis elegans (species) D	lanosterol c14 demethylase	Caenorhabditis elegans (species)	Published - Accepted by Curator
lanosterol c14 demethylase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intergeneric or Higher	Candidate Gene	Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001952	CYP51A1 Q16850	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Drosophila melanogaster fruit fly - (species) D	lanosterol c14 demethylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
lanosterol synthase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intergeneric or Higher	Candidate Gene	Kurzchalia TV; Ward S (2003) Why do worms need cholesterol? 1 Additional References Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001949	LSS P48449	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Drosophila melanogaster fruit fly - (species) D	lanosterol synthase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
lanosterol synthase	Cholesterol metabolism (cholesterol biosynthesis)	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intergeneric or Higher	Candidate Gene	Kurzchalia TV; Ward S (2003) Why do worms need cholesterol? 1 Additional References Vinci G; Xia X; Veitia RA (2008) Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.	GP00001950	LSS P48449	Physiology	gene absent in the genome N	Homo sapiens human - (species)	Caenorhabditis elegans (species) D	lanosterol synthase	Caenorhabditis elegans (species)	Published - Accepted by Curator
Ldia2 - Diaphanous-related formin	Shell chirality (coiling)	Coding, Deletion N	Lymnaea stagnalis great pond snail - (species) D	Intraspecific	Association Mapping	Davison A; McDowell GS; Holden JM ; et al. (2016) Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.	GP00000538	DIAPH1 O60610	Morphology	1bp deletion resulting in frame-shift (pseudogenization) N	Lymnaea stagnalis great pond snail - (species)	Lymnaea stagnalis great pond snail - (species) D	Ldia2 - Diaphanous-related formin	Lymnaea stagnalis great pond snail - (species)	Published - Accepted by Curator
LEU2	Xenobiotic resistance	Gene Loss, Complex Change N	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Perlstein EO; Ruderfer DM; Roberts DC ; et al. (2007) Genetic basis of individual differences in the response to small-molecule drugs in yeast.	GP00000542	LEU2 P04173	Physiology	Deletion N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	LEU2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
LIMONENE-MYRCENE SYNTHASE (LMS)	Fragrance (floral terpenoid volatiles; D -limonene and beta-myrcene)	Coding, SNP N	Erythranthe cardinalis (species) D	Interspecific	Linkage Mapping	Byers KJ; Vela JP; Peng F ; et al. (2014) Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...]	GP00001761	LMS W6A2K5	Physiology	G66T transversion mutation in exon 3 of McLMS (KM659024) that results in a nonsense mutation in the McLMS protein (G201X) N	Erythranthe lewisii (species)	Erythranthe cardinalis (species) D	LIMONENE-MYRCENE SYNTHASE (LMS)	Erythranthe cardinalis (species)	Published - Accepted by Curator
Linamarase	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000549	LI P26205	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D	Linamarase	Trifolium repens white clover - (species)	Published - Accepted by Curator
LIPH	Hair length	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Linkage Mapping	Diribarne M; Mata X; Chantry-Darmon C ; et al. (2011) A deletion in exon 9 of the LIPH gene is responsible for the rex hair coat phenotype in rabbits (Ory[...]	GP00000550	Liph Q8CIV3	Morphology	1bp deletion resulting in frameshift N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	LIPH	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
Low-density lipoprotein receptor-related protein 2	Organ size (eye; enlarged)	3 Mutations: Coding N	Carassius auratus goldfish - (species) D	Domesticated	Association Mapping	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002349	LRP2 P98164	Morphology	3 mutations	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D	Low-density lipoprotein receptor-related protein 2	Carassius auratus goldfish - (species)	Published - Accepted by Curator
Lysine histidine transporter 1	Pathogen resistance	Coding, Insertion N	Zea mays (species) D	Domesticated	Linkage Mapping	Zhao Y; Lu X; Liu C ; et al. (2012) Identification and fine mapping of rhm1 locus for resistance to Southern corn leaf blight in maize.	GP00000555	LHT1 Q9FKS8	Physiology	354bp insertioin resulting in premature stop codon N	Zea mays (species)	Zea mays (species) D	Lysine histidine transporter 1	Zea mays (species)	Published - Accepted by Curator
mab-23	Male genitalia	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Lints R; Emmons SW (2002) Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the [...] 1 Additional References Hodgkin J; Doniach T (1997) Natural variation and copulatory plug formation in Caenorhabditis elegans.	GP00001323	mab-23 G5ECK3	Morphology	TGC>TTC - cysteine of the DM motif transformed into phenylalanine; so is likely to disrupt DNA-binding function N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	mab-23	Caenorhabditis elegans (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000567	MC1R Q01726	Morphology	2bp deletion resulting in frameshift N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D	MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Klungland H; Våge DI; Gomez-Raya L ; et al. (1995) The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. 1 Additional References Joerg H; Fries HR; Meijerink E (1996) Red coat color in Holstein cattle is associated with a deletion in the MSHR gene.	GP00000571	MC1R Q01726	Morphology	1 bp deletion at 104: frameshift and premature stop at amino acid 156 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	MC1R	Bos taurus cattle - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Gene Loss, Complex Change N	Cavia porcellus domestic guinea pig - (species) D	Domesticated	Candidate Gene	Cone RD; Lu D; Koppula S ; et al. (1996) The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.	GP00000575	MC1R Q01726	Morphology	Deletion of part or all of gene N	Cavia porcellus domestic guinea pig - (species)	Cavia porcellus domestic guinea pig - (species) D	MC1R	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000582	MC1R Q01726	Morphology	1bp deletion at 183; frameshift & premature stop N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, Insertion N	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Linkage Mapping	Kijas JM; Moller M; Plastow G ; et al. (2001) A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pig[...] 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000631	MC1R Q01726	Morphology	2bp insertion at 23 generates early stop @ 56 & D"121"N ? N	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D	MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP N	Bos grunniens domestic yak - (species) D	Domesticated	Candidate Gene	Zhang MQ; Xu X; Luo SJ (2014) The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens).	GP00001354	Mc1r Q01727	Morphology	p.Gln34* and p.Met73Leu and p.Arg142Pro - p.Met73Leu and p.Arg142Pro were only found in heterozygous and their association with phenotype is supposed but not sure N	Bos grunniens domestic yak - (species)	Bos grunniens domestic yak - (species) D	MC1R	Bos grunniens domestic yak - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	2 Mutations: Coding SNP	Meleagris gallopavo mexicana (subspecies) D	Domesticated	Candidate Gene	Vidal O; Viñas J; Pla C (2010) Variability of the melanocortin 1 receptor (MC1R) gene explains the segregation of the bronze locus [...]	GP00002300	MC1R Q01726	Morphology	2 mutations	Meleagris gallopavo mexicana (subspecies)	Meleagris gallopavo mexicana (subspecies) D	MC1R	Meleagris gallopavo mexicana (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dürig N; Letko A; Lepori V ; et al. (2018) Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies.	GP00002301	MC1R Q01726	Morphology	2-bp deletion in the coding sequence c.816_817delCT N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dreger DL; Schmutz SM (2010 Sep-Oct) A new mutation in MC1R explains a coat color phenotype in 2 "old" breeds: Saluki and Afghan hound.	GP00002303	MC1R Q01726	Morphology	c.233G>T p.G78V N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Li W; Sartelet A; Tamma N ; et al. (2016) Reverse genetic screen for loss-of-function mutations uncovers a frameshifting deletion in the melan[...]	GP00000642	Mlph Q91V27	Morphology	10bp deletion in exon1 ; c.87_96del p.Glu32Aspfs*1 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Melanophilin (MLPH)	Bos taurus cattle - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Ishida Y; David VA; Eizirik E ; et al. (2006) A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat[...]	GP00000644	Mlph Q91V27	Morphology	1bp deletion resulting in frameshift c.83delT N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	Melanophilin (MLPH)	Felis catus domestic cat - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Cirera S; Markakis MN; Christensen K ; et al. (2013) New insights into the melanophilin (MLPH) gene controlling coat color phenotypes in American mink.	GP00000646	Mlph Q91V27	Morphology	deletion including intron 7 and exon 8 N	Neovison vison American mink - (species)	Neovison vison American mink - (species) D	Melanophilin (MLPH)	Neovison vison American mink - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Oryctolagus (genus) D	Domesticated	Candidate Gene	Fontanesi L; Scotti E; Allain D ; et al. (2014) A frameshift mutation in the melanophilin gene causes the dilute coat colour in rabbit (Oryctolagus [...]	GP00000648	Mlph Q91V27	Morphology	1bp deletion resulting in frameshift N	Oryctolagus (genus)	Oryctolagus (genus) D	Melanophilin (MLPH)	Oryctolagus (genus)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Van Buren SL; Minor KM; Grahn RA ; et al. (2020) A Third MLPH Variant Causing Coat Color Dilution in Dogs.	GP00002331	Mlph Q91V27	Morphology	c.667_668insC p.(His223Profs*41) N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	Melanophilin (MLPH)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Lehner S; Gähle M; Dierks C ; et al. (2013) Two-exon skipping within MLPH is associated with coat color dilution in rabbits.	GP00002332	Mlph Q91V27	Morphology	c.585delG p.L195LfsX123* N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	Melanophilin (MLPH)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
MFSD12	Coloration (coat)	Coding, Insertion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Tanaka J; Leeb T; Rushton J ; et al. (2019) Frameshift Variant in MFSD12 Explains the Mushroom Coat Color Dilution in Shetland Ponies.	GP00002243	MFSD12 Q6NUT3	Morphology	p.(Asp201fs) due to c.600Cins N	Equus caballus horse - (species)	Equus caballus horse - (species) D	MFSD12	Equus caballus horse - (species)	Published - Accepted by Curator
MFSD12	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Hédan B; Cadieu E; Botherel N ; et al. (2019) Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White[...]	GP00002244	MFSD12 Q6NUT3	Morphology	c.151C>T p.Arg51Cys N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D	MFSD12	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MFSD12	Coloration (skin)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Adhikari K; Mendoza-Revilla J; Sohail A ; et al. (2019) A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasi[...] 1 Additional References Crawford NG; Kelly DE; Hansen MEB (2017) Loci associated with skin pigmentation identified in African populations.	GP00002245	MFSD12 Q6NUT3	Morphology	Y182H N	Homo sapiens human - (species)	Homo sapiens human - (species) D	MFSD12	Homo sapiens human - (species)	Published - Accepted by Curator
MFSD12	Coloration (skin)	Cis-regulatory, Complex Change N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Crawford NG; Kelly DE; Hansen MEB ; et al. (2017) Loci associated with skin pigmentation identified in African populations.	GP00002246	MFSD12 Q6NUT3	Morphology	eight potentially causal SNPs cluster in two regions: one within MFSD12 (intronic SNP and synonymous SNP in exon 9) and the other ~7600 to 9000 base pairs (bp) upstream of MFSD12 ; many SNPs are in predicted regulatory regions active in melanocytes and/or keratinocytes show enhancer activity in luciferase expression assays N	Homo sapiens human - (species)	Homo sapiens human - (species) D	MFSD12	Homo sapiens human - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (feathers)	Coding, Deletion N	Coturnix japonica Japanese quail - (species) D	Domesticated	Candidate Gene	Minvielle F; Bed'hom B; Coville JL ; et al. (2010) The "silver" Japanese quail and the MITF gene: causal mutation, associated traits and homology with [...] 1 Additional References Mochii M; Ono T; Matsubara Y (1998) Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in [...]	GP00000660	Mitf Q08874	Morphology	2bp deletion N	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species) D	Microphtalmia-associated transcription factor	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Haase B; Blatter M ; et al. (2012) Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.	GP00002322	Mitf Q08874	Morphology	c.519_523delGTGTC p.C174Sfs*20 N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Henkel J; Lafayette C; Brooks SA ; et al. (2019) Whole-genome sequencing reveals a large deletion in the MITF gene in horses with white spotted coat [...]	GP00002324	Mitf Q08874	Morphology	~63-kb deletion spanning exons 6-9 N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Magdesian KG; Tanaka J; Bellone RR (2020) A De Novo MITF Deletion Explains a Novel Splashed White Phenotype in an American Paint Horse.	GP00002325	Mitf Q08874	Morphology	8.7 kb deletion N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP N	Bubalus bubalis water buffalo - (species) D	Domesticated	Candidate Gene	Yusnizar Y; Wilbe M; Herlino AO ; et al. (2015) Microphthalmia-associated transcription factor mutations are associated with white-spotted coat colo[...]	GP00002327	Mitf Q08874	Morphology	c.328C>T p.R110* N	Bubalus bubalis water buffalo - (species)	Bubalus bubalis water buffalo - (species) D	Microphtalmia-associated transcription factor	Bubalus bubalis water buffalo - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP N	Bubalus bubalis water buffalo - (species) D	Domesticated	Candidate Gene	Yusnizar Y; Wilbe M; Herlino AO ; et al. (2015) Microphthalmia-associated transcription factor mutations are associated with white-spotted coat colo[...]	GP00002328	Mitf Q08874	Morphology	donor splice-site mutation leads to aberrant splicing of exon 8 that encodes part of a highly conserved region of MITF N	Bubalus bubalis water buffalo - (species)	Bubalus bubalis water buffalo - (species) D	Microphtalmia-associated transcription factor	Bubalus bubalis water buffalo - (species)	Published - Accepted by Curator
miR-15a-16	Body size (weight)	Cis-regulatory, Insertion N	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Jia X; Lin H; Nie Q ; et al. (2016) A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticat[...]	GP00002247		Morphology	54-bp insertion introducing splicing site that affect the mature transcript N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D	miR-15a-16	Gallus gallus chicken - (species)	Published - Accepted by Curator
MLO1	Pathogen resistance	Coding, SNP N	Pisum sativum pea - (species)	Domesticated	Linkage Mapping	Pavan S; Schiavulli A; Appiano M ; et al. (2011) Pea powdery mildew er1 resistance is associated to loss-of-function mutations at a MLO homologous lo[...]	GP00000673	MLO P93766	Physiology	1bp substitution resulting in premature stop codon N	Pisum sativum pea - (species)	Pisum sativum pea - (species)	MLO1	Pisum sativum pea - (species)	Published - Accepted by Curator
MLO1	Pathogen resistance	Coding, Deletion N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Bai Y; Pavan S; Zheng Z ; et al. (2008) Naturally occurring broad-spectrum powdery mildew resistance in a Central American tomato accession [...]	GP00000674	MLO P93766	Physiology	19bp deletion resulting in frameshift N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D	MLO1	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Mpv17	Coloration (albinism; iridophores)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002358	mpv17 Q5TZ51	Morphology; Physiology	Deletion which removes 16 amino acids in a conserved region. The Mpv17 mutant in zebrafish displays a strong reduction of iridophores throughout larval and adult stages. N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D	Mpv17	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
MRC2	Muscular mass Tail shape (crooked ; defect)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Association Mapping	Fasquelle C; Sartelet A; Li W ; et al. (2009) Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Croo[...] 2 Additional References Sartelet A; Klingbeil P; Franklin CK (2012) Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection? Druet T; Ahariz N; Cambisano N (2014) Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian[...]	GP00002264	MRC2 Q9UBG0	Physiology Morphology	c.2904-2905delAG p.Gly934X N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	MRC2	Bos taurus cattle - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00000679	CUP1-1 P0CX80	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00000680	CUP1-1 P0CX80	Physiology	Ty retrotranposition resulting in a coding frameshift N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Macquet A; Ralet MC; Loudet O ; et al. (2007) A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...]	GP00000681	BGAL6 Q9FFN4	Physiology	44bp deletion in exon 15; from Leu-662 onwards. This deletion causes a frame-shift mutation changing the next 23 amino acids followed by the introduction of a stop codon. N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001274	BGAL6 Q9FFN4	Physiology	C->T @position 2223 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001275	BGAL6 Q9FFN4	Physiology	G->C @position 2240 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001276	BGAL6 Q9FFN4	Physiology	G->T @position 3425 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001277	BGAL6 Q9FFN4	Physiology	TACA insertion @position 4906 causing frame shift + Stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MYB-FL	Coloration (flower ; UV absorbance)	Coding, Deletion N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Sheehan H; Moser M; Klahre U ; et al. (2016) MYB-FL controls gain and loss of floral UV absorbance, a key trait affecting pollinator preference a[...]	GP00001590	MYB-FL A0A0S3CVC7	Morphology	A 1-bp deletion in exon 3 causing a frameshift resulting in a truncated protein N	Petunia axillaris (species)	Petunia exserta (species) D	MYB-FL	Petunia exserta (species)	Published - Accepted by Curator
MYB1	Coloration (flower)	Coding, Deletion N	Ipomoea purpurea common morning-glory - (species) D	Intraspecific	Candidate Gene	Chang SM; Lu Y; Rausher MD (2005) Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea.	GP00001458	myb1 Q4QS21	Morphology	2 deletions; 6-bp and 19-bp long; the larger produces a frameshift and a premature stop N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D	MYB1	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
MYB1	Coloration (flowers; seeds; stems)	Coding, Deletion N	Ipomoea nil Japanese morning glory - (species) D	Domesticated	Candidate Gene	Morita Y; Saitoh M; Hoshino A ; et al. (2006) Isolation of cDNAs for R2R3-MYB, bHLH and WDR transcriptional regulators and identification of c and[...]	GP00002089	myb1 Q4QS21	Morphology	frameshift mutation caused by a 2 bp deletion N	Ipomoea nil Japanese morning glory - (species)	Ipomoea nil Japanese morning glory - (species) D	MYB1	Ipomoea nil Japanese morning glory - (species)	Published - Accepted by Curator
myosin heavy chain 16 (MYH16)	Masticatory muscles	Coding, Deletion N	Homo sapiens human - (species) D	Intergeneric or Higher	Candidate Gene	Stedman HH; Kozyak BW; Nelson A ; et al. (2004) Myosin gene mutation correlates with anatomical changes in the human lineage.	GP00000683	MYH16 Q9H6N6	Morphology	2bp deletion at codon 660 N	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D	myosin heavy chain 16 (MYH16)	Homo sapiens human - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Grobet L; Martin LJ; Poncelet D ; et al. (1997) A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. 2 Additional References McPherron AC; Lee SJ (1997) Double muscling in cattle due to mutations in the myostatin gene. Kambadur R; Sharma M; Smith TP (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.	GP00000685	MSTN O14793	Morphology	nt821 11bp deletion c.821-831delTGAACACTCCA p.Glu275ArgfsX14 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Indel N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000686	MSTN O14793	Morphology	nt419 7bp deletion and 10bp insertion; leading to a premature stop codon at position 140 c.419_425del7, c418_426ins10 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000687	MSTN O14793	Morphology	c.610C>T p.Q204* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000688	MSTN O14793	Morphology	E226* caused by G676T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Marchitelli C; Savarese MC; Crisà A ; et al. (2003) Double muscling in Marchigiana beef breed is caused by a stop codon in the third exon of myostatin g[...]	GP00000690	MSTN O14793	Morphology	E291* caused by G>T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Boman IA; Klemetsdal G; Blichfeldt T ; et al. (2009) A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation[...]	GP00000693	MSTN O14793	Morphology	1bp deletion resulting in a premature stop codon at position 320 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	Myostatin (MSTN = GDF8)	Ovis aries sheep - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Insertion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Boman IA; Våge DI (2009) An insertion in the coding region of the myostatin (MSTN) gene affects carcass conformation and fatn[...]	GP00000694	MSTN O14793	Morphology	1bp insertion resulting in premature stop codon at position 49 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	Myostatin (MSTN = GDF8)	Ovis aries sheep - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Racing performance	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Mosher DS; Quignon P; Bustamante CD ; et al. (2007) A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygo[...]	GP00000697	MSTN O14793	Morphology; Physiology	2bp deletion in the third exon c.939_940delTG p.C313* N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	Myostatin (MSTN = GDF8)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
NAM-B1 (=Gpc-B1)	Grain content Senescence (grain)	Coding, Insertion N	Triticum turgidum (species) D	Domesticated	Linkage Mapping	Uauy C; Distelfeld A; Fahima T ; et al. (2006) A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat.	GP00000717	NAM-B1 A0SPJ4	Physiology Physiology	1bp insertion resulting in frameshift N	Triticum turgidum (species)	Triticum turgidum (species) D	NAM-B1 (=Gpc-B1)	Triticum turgidum (species)	Published - Accepted by Curator
ndp (norrin)	Coloration (plumage)	Coding, SNP N	Columba livia rock pigeon - (species) D	Domesticated	Association Mapping	Vickrey AI; Bruders R; Kronenberg Z ; et al. (2018) Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity i[...]	GP00002250	Ndp P48744	Morphology	Start-codon change predicted to truncate the amino terminus of the NDP protein by 11 amino acids thereby disrupting the 24-amino acid signal peptide sequence N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D	ndp (norrin)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
ndp (norrin)	Coloration (plumage)	Cis-regulatory, Insertion N	Columba livia rock pigeon - (species) D Columba guinea speckled pigeon - (species) D	Intraspecific	Association Mapping	Vickrey AI; Bruders R; Kronenberg Z ; et al. (2018) Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity i[...]	GP00002251	Ndp P48744	Morphology	CNV driven by tandem repeats with one (bar) two (checker) or four (T-checker) copies per chromosome between approximative positions 1790000 and 1805600 N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D Columba guinea speckled pigeon - (species) D	ndp (norrin)	Columba livia rock pigeon - (species) Columba guinea speckled pigeon - (species)	Published - Accepted by Curator
neurogenin 3	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001915	NEUROG3 Q9Y4Z2	Physiology	Absence of the gene in the genome sequence - Neurogenin-3 is a transcription factor whose activity is required for the specification of gastric epithelial cell identity - Deficiency of this factor results in considerably smaller stomachs and absence of gastrin-secreting G cells: somatostatin-secreting D cells and glucagon-secreting A cells N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	neurogenin 3	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000745	Oca2 Q62052	Morphology Physiology	Deletion of exon 21 N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D	Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000746	Oca2 Q62052	Morphology Physiology	Almost complete deletion of exon 24; + 2 a.a subsitutions at conserved positions - the two point mutations do not drastically affect the function of OCA2 in cell lines suggesting that the exon 24 deletion is the mutation that causes albinism in the Pachón population N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D	Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Insertion N	Pantherophis guttatus (species) D	Intraspecific	Linkage Mapping	Saenko SV; Lamichhaney S; Martinez Barrio A ; et al. (2015) Amelanism in the corn snake is associated with the insertion of an LTR-retrotransposon in the OCA2 g[...]	GP00001619	OCA2 Q04671	Morphology	insertion of an LTR-retrotransposon (5832-bp) in the 11th intron resulting after splicing in an additional 397-bp fragment constituted of 3 new exons inserted between exons 11 and 12. Generates truncated protein with two stop codons N	Pantherophis guttatus (species)	Pantherophis guttatus (species) D	Oca2	Pantherophis guttatus (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Deletion N	Melanochromis auratus (species) D	Intraspecific	Candidate Gene	Kratochwil CF; Urban S; Meyer A (2019) Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an ame[...]	GP00001955	Oca2 Q62052	Morphology	deletion covering a total of 5.4kb including exon 2 and parts of the flanking introns 1 and 2 N	Melanochromis auratus (species)	Melanochromis auratus (species) D	Oca2	Melanochromis auratus (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Insertion N	Carassius auratus goldfish - (species) D	Domesticated	Candidate Gene	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002351	Oca2 Q62052	Morphology	1-bp insert creating a frameshift and a truncated protein (470 amino acids instead of 805). In oca2L ohnolog on chromosome LG6. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D	Oca2	Carassius auratus goldfish - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Deletion N	Carassius auratus goldfish - (species) D	Domesticated	Candidate Gene	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002352	Oca2 Q62052	Morphology	1-bp deletion creating a frameshift and a truncated protein (519 amino acids instead of 805). In oca2S ohnolog on chromosome LG31. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D	Oca2	Carassius auratus goldfish - (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, SNP N	Erythranthe cardinalis (species) D	Interspecific	Linkage Mapping	Byers KJ; Vela JP; Peng F ; et al. (2014) Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...] 1 Additional References Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001760	TPS02 P0CJ43	Physiology	multiple candidate coding sequence differences - together they eliminate the ability of the enzyme to produce E-beta-ocimene - effect of individual mutations not tested N	Erythranthe lewisii (species)	Erythranthe cardinalis (species) D	OCYMENE SYNTHASE (OS)	Erythranthe cardinalis (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, Deletion N	Erythranthe verbenacea (species) D	Interspecific	Candidate Gene	Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001762	TPS02 P0CJ43	Physiology	large deletion from the third exon to the last exon N	Erythranthe lewisii (species)	Erythranthe verbenacea (species) D	OCYMENE SYNTHASE (OS)	Erythranthe verbenacea (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, Insertion N	Erythranthe bicolor (species) D	Interspecific	Candidate Gene	Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001763	TPS02 P0CJ43	Physiology	2-bp insertion in the second exon, producing a frameshift mutation and premature termination N	Erythranthe lewisii (species)	Erythranthe bicolor (species) D	OCYMENE SYNTHASE (OS)	Erythranthe bicolor (species)	Published - Accepted by Curator
opaque2 (O2)	Lysine content (endosperm)	Coding, Deletion N	Zea mays (species) D	Domesticated	Linkage Mapping	Schmidt RJ; Burr FA; Burr B (1987) Transposon tagging and molecular analysis of the maize regulatory locus opaque-2. 1 Additional References Hartings H; Lazzaroni N; Rossi V (1995) Molecular analysis of opaque-2 alleles from Zea mays L. reveals the nature of mutational events and [...]	GP00000753	O2 P12959	Physiology	1bp deletion predicted to cause premature termination of translation N	Zea mays (species)	Zea mays (species) D	opaque2 (O2)	Zea mays (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision	Coding, Deletion N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000756	OPN1SW P03999	Physiology	4bp frameshift deletion in exon 1 of SWS1 that results in a premature stop codon N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D	opsin - (SWS1)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (loss of violet-range sensitivity)	Coding, Deletion N	Sciurus carolinensis gray squirrel - (species) D	Intergeneric or Higher	Candidate Gene	Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006) Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.	GP00000758	OPN1SW P03999	Physiology	6bp deletion (residues 77-78) + 1bp frameshift deletion N	Sciurus carolinensis gray squirrel - (species)	Sciurus carolinensis gray squirrel - (species) D	opsin - (SWS1)	Sciurus carolinensis gray squirrel - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Deletion N	Balaenopteridae rorquals - (family) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000771	OPN1LW P04000	Physiology	22bp deletion including transciption start N	Cetacea whales - (order)	Balaenopteridae rorquals - (family) D	opsin - rhodopsin (LWS)	Balaenopteridae rorquals - (family)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Deletion N	Kogia breviceps pygmy sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000772	OPN1LW P04000	Physiology	44bp frameshift deletion 9 + possibly GT to CT splice site mutation N	Cetacea whales - (order)	Kogia breviceps pygmy sperm whale - (species) D	opsin - rhodopsin (LWS)	Kogia breviceps pygmy sperm whale - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Deletion N	Physeter catodon sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000773	OPN1LW P04000	Physiology	1bp + 28bp frameshift deletions N	Cetacea whales - (order)	Physeter catodon sperm whale - (species) D	opsin - rhodopsin (LWS)	Physeter catodon sperm whale - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Insertion N	Mesoplodon bidens Sowerby's beaked whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000774	OPN1LW P04000	Physiology	4bp frameshift insertion in exon 2 of LWS N	Cetacea whales - (order)	Mesoplodon bidens Sowerby's beaked whale - (species) D	opsin - rhodopsin (LWS)	Mesoplodon bidens Sowerby's beaked whale - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Gene Loss, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002353	OPN1LW P04000	Physiology	Lws2 coding sequence absent from the full genome sequence N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	opsin - rhodopsin (LWS)	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
Os07g0603400	Grain size Grain quality	2 Mutations: Coding SNP N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Wang Y; Xiong G; Hu J ; et al. (2015) Copy number variation at the GL7 locus contributes to grain size diversity in rice.	GP00001542	Os07g0603400 A3BLY4	Morphology Physiology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Os07g0603400	Oryza sativa rice - (species)	Published - Accepted by Curator
OsC1	Coloration (loss of apiculus color)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Saitoh K; Onishi K; Mikami I ; et al. (2004) Allelic diversification at the C (OsC1) locus of wild and cultivated rice: nucleotide changes associ[...] 2 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Huang X; Kurata N; Wei X (2012) A map of rice genome variation reveals the origin of cultivated rice.	GP00000805	C Q76B79	Morphology	10bp deletion N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	OsC1	Oryza sativa rice - (species)	Published - Accepted by Curator
OsC1	Coloration (loss of apiculus color)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Saitoh K; Onishi K; Mikami I ; et al. (2004) Allelic diversification at the C (OsC1) locus of wild and cultivated rice: nucleotide changes associ[...] 2 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Huang X; Kurata N; Wei X (2012) A map of rice genome variation reveals the origin of cultivated rice.	GP00000806	C Q76B79	Morphology	2bp deletion N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	OsC1	Oryza sativa rice - (species)	Published - Accepted by Curator
OsCKX2=Gn1a	Grain yield	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Ashikari M; Sakakibara H; Lin S ; et al. (2005) Cytokinin oxidase regulates rice grain production.	GP00000807	CKX2 Q4ADV8	Morphology	11bp deletion causing premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	OsCKX2=Gn1a	Oryza sativa rice - (species)	Published - Accepted by Curator
OVATE	Fruit shape	Coding, SNP N	Solanum lycopersicum tomato - (species)	Domesticated	Linkage Mapping	Liu J; Van Eck J; Cong B ; et al. (2002) A new class of regulatory genes underlying the cause of pear-shaped tomato fruit.	GP00000815	Q8GSM4	Morphology	V164* caused by G>T; which leads to a 75-aa truncation in the C terminus of the predicted protein N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species)	OVATE	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00000817	LPAR6 P43657	Morphology	at position 69 insertion of 4bp CATG - causes frameshift at codon 24 (PTC +29) N	Homo sapiens human - (species)	Homo sapiens human - (species) D	P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001734	LPAR6 P43657	Morphology	2 deletions - one at position 172-175 delAACT and one at position 177 delG - cause frameshift at codon 58 (PTC +31) N	Homo sapiens human - (species)	Homo sapiens human - (species) D	P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001735	LPAR6 P43657	Morphology	188A>T which causes D63V N	Homo sapiens human - (species)	Homo sapiens human - (species) D	P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001736	LPAR6 P43657	Morphology	562A>T which causes I188F N	Homo sapiens human - (species)	Homo sapiens human - (species) D	P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001737	LPAR6 P43657	Morphology	565G>A which causes E189K N	Homo sapiens human - (species)	Homo sapiens human - (species) D	P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
PAP1	Coloration (anthocyanin accumulation under high-light and low-temperature stress)	Gene Loss, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ilk N; Ding J; Ihnatowicz A ; et al. (2015) Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...] 1 Additional References Teng S; Keurentjes J; Bentsink L (2005) Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene.	GP00001232	MYB75 Q9FE25	Physiology	several deletions in the promoter; first intron; second exon and 3' UTR region (putative loss of function) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	PAP1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001321	peel-1 G5EGC6	Physiology	1bp deletion creating a frameshift starting at amino acid position 43. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001322	peel-1 G5EGC6	Physiology	G>T - glycine to stop codon at position 57. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1/zeel-1	Hybrid incompatibility	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection. 1 Additional References Seidel HS; Ailion M; Li J (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]	GP00001320	peel-1 G5EGC6	Physiology	19kb deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	peel-1/zeel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
pepsinogen A	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001911	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	pepsinogen A	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
pepsinogen A1	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001917	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species) Oreochromis niloticus Nile tilapia - (species)	Danio rerio zebrafish - (species) D	pepsinogen A1	Danio rerio zebrafish - (species)	Published - Accepted by Curator
pepsinogen A1	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001924	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	pepsinogen A1	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
pepsinogen A1	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001930	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	pepsinogen A1	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
pepsinogen A2	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001918	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species) Oreochromis niloticus Nile tilapia - (species)	Danio rerio zebrafish - (species) D	pepsinogen A2	Danio rerio zebrafish - (species)	Published - Accepted by Curator
pepsinogen A2	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001925	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	pepsinogen A2	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
pepsinogen A2	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001931	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	pepsinogen A2	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
pepsinogen A3	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001919	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Danio rerio zebrafish - (species) D	pepsinogen A3	Danio rerio zebrafish - (species)	Published - Accepted by Curator
pepsinogen A3	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001926	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	pepsinogen A3	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
pepsinogen A3	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001927	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	pepsinogen A3	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
pepsinogen A3	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001932	PGA4 P0DJD7	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	pepsinogen A3	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
pepsinogen B	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001913	PGB Q8SQ41	Physiology	Absence of the gene in the genome sequence - high synteny N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	pepsinogen B	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
pepsinogen C	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001912	PGC P20142	Physiology	Absence of the gene in the genome sequence - high synteny N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	pepsinogen C	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
PER36	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Macquet A; Ralet MC; Loudet O ; et al. (2007) A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...] 1 Additional References Kunieda T; Shimada T; Kondo M (2013) Spatiotemporal secretion of PEROXIDASE36 is required for seed coat mucilage extrusion in Arabidopsis[...]	GP00001273	PER36 Q9SD46	Physiology	Tyrosine @position 262bp to a stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	PER36	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
PG	Fruit ripening	Coding, Deletion N	Capsicum annuum (species) D	Domesticated	Candidate Gene	Kim S; Park M; Yeom SI ; et al. (2014) Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]	GP00001448	PG B9VRK6	Physiology	a partial deletion of about 90aa in the C-terminal region N	Solanum lycopersicum tomato - (species)	Capsicum annuum (species) D	PG	Capsicum annuum (species)	Published - Accepted by Curator
PG	Fruit ripening	Coding, SNP N	Capsicum chinense (species) D	Domesticated	Candidate Gene	Kim S; Park M; Yeom SI ; et al. (2014) Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]	GP00001449	PG B9VRK6	Physiology	a point mutation in the 3' splice acceptor site of intron VIII generates a premature stop codon N	Solanum lycopersicum tomato - (species)	Capsicum chinense (species) D	PG	Capsicum chinense (species)	Published - Accepted by Curator
PH4/GmMYB-G20-1	Coloration (flowers)	Coding, SNP N	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Takahashi R; Benitez ER; Oyoo ME ; et al. (2011 Jul-Aug) Nonsense mutation of an MYB transcription factor is associated with purple-blue flower color in soyb[...]	GP00000862	PH4 Q2TCH0	Morphology	Substitution creating premature Stop (codon 158) N	Glycine max soybean - (species)	Glycine max soybean - (species)	PH4/GmMYB-G20-1	Glycine max soybean - (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	2 Mutations: Coding SNP N	Flaveria trinervia (species)	Interspecific	Candidate Gene	Bläsing OE; Westhoff P; Svensson P (2000) Evolution of C4 phosphoenolpyruvate carboxylase in Flaveria, a conserved serine residue in the carbo[...] 1 Additional References Engelmann S; Bläsing OE; Gowik U (2003) Molecular evolution of C4 phosphoenolpyruvate carboxylase in the genus Flaveria--a gradual increase [...]	GP00000867	PPCA P30694	Physiology	2 mutations	Flaveria pringlei (species)	Flaveria trinervia (species)	phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
phytochrome A (PHYA)	Light sensitivity High-altitude adaptation	Coding, Insertion N	Glycine max soybean - (species) D	Domesticated	Candidate Gene	Liu B; Kanazawa A; Matsumura H ; et al. (2008) Genetic redundancy in soybean photoresponses associated with duplication of the phytochrome A gene. 1 Additional References Kanazawa A; Liu B; Kong F (2009) Adaptive evolution involving gene duplication and insertion of a novel Ty1/copia-like retrotransposo[...]	GP00002104	PHYA P14712	Physiology Physiology	insertion of a retrotransposon in exon 1 - The transposable element is SORE-1 = a novel Ty1/copia-like retrotransposon in soybean N	Glycine max soybean - (species)	Glycine max soybean - (species) D	phytochrome A (PHYA)	Glycine max soybean - (species)	Published - Accepted by Curator
phytochrome C (PHYC)	Light sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006) The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]	GP00000873	PHYC P14714	Physiology	K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	phytochrome C (PHYC)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome D (PHYD)	Leaf morphology (increased petiole length) Cotyledon morphology (reduced cotyledon area) Coloration (anthocyanin accumulation in seedling stems) Plant size (diminished effect of end-of-day pulse of far red light on hypocotyl elongation) Plant architecture (decrease in number of rosette leaves at onset of flowering)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Aukerman MJ; Hirschfeld M; Wester L ; et al. (1997) A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome [...]	GP00000874	PHYD P42497	Morphology Morphology Morphology Physiology Morphology	14bp deletion causing premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	phytochrome D (PHYD)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytoene synthase	Carotenoid content (fruit)	Coding, Insertion N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Fray RG; Grierson D (1993) Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequen[...] 1 Additional References Gilbert C; Feschotte C (2018) Horizontal acquisition of transposable elements and viral sequences: patterns and consequences.	GP00001718	PSY1 P49085	Physiology	insertion of a Rider transposable element within the coding region N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D	phytoene synthase	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
phytoene synthase	Carotenoid content (fruit)	Coding, Indel N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Fray RG; Grierson D (1993) Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequen[...] 1 Additional References Gilbert C; Feschotte C (2018) Horizontal acquisition of transposable elements and viral sequences: patterns and consequences.	GP00001719	PSY1 P49085	Physiology	r y cDNA was found to be mutated at its 3' end, lacking the last 237 bases of PSY1 coding sequence and containing 185 nucleotides of an unrelated sequence in its place N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D	phytoene synthase	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Pid3	Pathogen resistance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Chen J; Shi Y; Liu W ; et al. (2011) A Pid3 allele from rice cultivar Gumei2 confers resistance to Magnaporthe oryzae.	GP00000883	Pid3 C0LMX9	Physiology	1bp deletion resulting in truncated protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Pid3	Oryza sativa rice - (species)	Published - Accepted by Curator
plg-1	Copulatory plug	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Palopoli MF; Rockman MV; TinMaung A ; et al. (2008) Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.	GP00000898		Physiology	insertion of transposable element in an exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	plg-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
PMEI6	Mucilage (seeds)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis. 1 Additional References Saez-Aguayo S; Ralet MC; Berger A (2013) PECTIN METHYLESTERASE INHIBITOR6 promotes Arabidopsis mucilage release by limiting methylesterificat[...]	GP00001272	AXX17_At2g45450 A0A178VVA1	Physiology	frameshift mutation due to a 1-bp insertion 581 bp after the ATG codon that changed amino acids 194 to 205 followed by the introduction of a stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	PMEI6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
poils au dos (pad)	Bristle number (thorax)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Gibert JM; Marcellini S; David JR ; et al. (2005) A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription [...]	GP00000915	pad Q9VEW6	Morphology	29bp deletion N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	poils au dos (pad)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Pore-forming toxin-like (PFT)	Pathogen resistance (Fusarium)	Gene Loss, Indel N	Triticum aestivum bread wheat - (species)	Intraspecific	Linkage Mapping	Rawat N; Pumphrey MO; Liu S ; et al. (2016) Wheat Fhb1 encodes a chimeric lectin with agglutinin domains and a pore-forming toxin-like domain co[...]	GP00001563	Q4JEV5	Physiology	PFT gene is present and constitutively expressed in resistant line and absent in susceptible line N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)	Pore-forming toxin-like (PFT)	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
pot-2	Telomere length	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Cook DE; Zdraljevic S; Tanny RE ; et al. (2016) The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.	GP00001317	pot-2 O45595	Physiology	Phenylalanine-to-isoleucine (F68I) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	pot-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
Potassium channel subfamily K	Fin morphology (skeleton; dorsal fin; caudal fin; tail; paired fin)	Coding, SNP N	Carassius auratus goldfish - (species) D	Domesticated	Association Mapping	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002348	KCNK5 O95279	Morphology	Substitution of a hydrophobic amino acid (valine) with a hydrophilic amino acid (glutamic acid) appears to cause a critical alteration of channel gating. In total there are five amino acid substitutions or deletions in kcnk5bS in goldfish with the long-tail phenotype. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D	Potassium channel subfamily K	Carassius auratus goldfish - (species)	Published - Accepted by Curator
PpeGID1c	Plant size (dwarfism)	Coding, SNP N	Prunus persica peach - (species) D	Domesticated	Linkage Mapping	Hollender CA; Hadiarto T; Srinivasan C ; et al. (2016) A brachytic dwarfism trait (dw) in peach trees is caused by a nonsense mutation within the gibberell[...]	GP00000920	GID1C Q940G6	Morphology	Trp162* (TGG>TAG) N	Prunus persica peach - (species)	Prunus persica peach - (species) D	PpeGID1c	Prunus persica peach - (species)	Published - Accepted by Curator
ppw-1	Resistance to dsRNA	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Tijsterman M; Okihara KL; Thijssen K ; et al. (2002) PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]	GP00000921		Physiology	1bp deletion resulting in stop codon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	ppw-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
PRKG2	Body size (dwarfism)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Koltes JE; Mishra BP; Kumar D ; et al. (2009) A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Ang[...]	GP00002273	PRKG2 Q13237	Morphology	c.1573C>T p.R525* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	PRKG2	Bos taurus cattle - (species)	Published - Accepted by Curator
PRKG2	Body size (dwarfism)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Koltes JE; Mishra BP; Kumar D ; et al. (2009) A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Ang[...]	GP00002274	PRKG2 Q13237	Morphology	c.2032C>T p.R678* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	PRKG2	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin	Hair length (short)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Littlejohn MD; Henty KM; Tiplady K ; et al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.	GP00002033	PRL P01239	Morphology	1-bp deletion in exon 10 that introduces a premature stop codon (p.Leu462*) and loss of 120 C-terminal amino acids from the long isoform of the receptor (ss1067289408; chr20:39136558GC>G) N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Prolactin	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Hair (slick ; short ; thermotolerance) Thermoregulation (tolerance to warm climate)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated		Littlejohn MD; Henty KM; Tiplady K ; et al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.	GP00002282	PRLR P16471	Morphology Physiology	g.39136559delC p.Leu462* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Hair (slick ; short) Thermoregulation (tolerance to warm climate)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated		Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018) Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.	GP00002283	PRLR P16471	Morphology Physiology	g.39136571C>A p.Ser465* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Hair (slick ; short) Thermoregulation (tolerance to warm climate)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated		Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018) Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.	GP00002284	PRLR P16471	Morphology Physiology	g.39136666C>T p.Arg497* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
prophenoloxidase 3 (PPO3)	Immune response (melanotic encapsulation by lamellocytes)	Coding, SNP N	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Dudzic JP; Kondo S; Ueda R ; et al. (2015) Drosophila innate immunity: regional and functional specialization of prophenoloxidases.	GP00001781	PPO3 Q9W1V6	Physiology	amino acid change at position 48 which converts the terminal glutamine residue of the propeptide region to a stop codon, and is predicted to generate a truncated version of the PPO3 protein N	Drosophila simulans (species) Drosophila mauritiana (species)	Drosophila sechellia (species) D	prophenoloxidase 3 (PPO3)	Drosophila sechellia (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	Coding, Deletion N	Sorghum bicolor sorghum - (species) D	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000930	PRR37 Q0D3B6	Physiology	1bp deletion resulting in frameshift N	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species) D	PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	2 Mutations: Coding SNP N	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000931	PRR37 Q0D3B6	Physiology	2 mutations	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)	PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, SNP N	Oryza sativa Japonica Group Japanese rice - (no rank) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001632	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-2a: L710P missense mutation in the CONSTANS-Co-like and TOC1 domain of the protein N	Oryza sativa rice - (species)	Oryza sativa Japonica Group Japanese rice - (no rank) D	PRR37 pseudoresponse regulator protein 37	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001633	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-1a: a 8-bp deletion at position 1515 leading to frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	PRR37 pseudoresponse regulator protein 37	Oryza sativa rice - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001634	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-1b: Y704H N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	PRR37 pseudoresponse regulator protein 37	Oryza sativa rice - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001635	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-1c: a premature stop Q705* N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	PRR37 pseudoresponse regulator protein 37	Oryza sativa rice - (species)	Published - Accepted by Curator
PsbHLH = A	Coloration (flowers)	Coding, SNP N	Pisum sativum pea - (species)	Domesticated	Linkage Mapping	Hellens RP; Moreau C; Lin-Wang K ; et al. (2010) Identification of Mendel's white flower character.	GP00000935	BHLH E3SXU4	Morphology	Splice site mutation: a simple G to A transition in a splice donor site that leads to a mis-spliced mRNA with a premature stop codon N	Pisum sativum pea - (species)	Pisum sativum pea - (species)	PsbHLH = A	Pisum sativum pea - (species)	Published - Accepted by Curator
qPE9-1	Plant architecture Inflorescence architecture	Coding, Indel N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Zhou Y; Zhu J; Li Z ; et al. (2009) Deletion in a quantitative trait gene qPE9-1 associated with panicle erectness improves plant archit[...]	GP00000941	PAY1 B8Y995	Morphology Morphology	637-bp deletion and 12-bp insertion resulting in truncated protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	qPE9-1	Oryza sativa rice - (species)	Published - Accepted by Curator
qSW5	Grain size	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Shomura A; Izawa T; Ebana K ; et al. (2008) Deletion in a gene associated with grain size increased yields during rice domestication. 1 Additional References Huang X; Wei X; Sang T (2010)