Gephebase

Gephebase Search Results

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Main Curator	Edit Gene-GePhe	Taxon B	Status	Validator Comment	Date of Sent Email
ABCC11	Apocrine secretion (ear wax type ; axillary odor)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Yoshiura K; Kinoshita A; Ishida T ; et al. (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. 1 Additional References Martin A; Saathoff M; Kuhn F (2010) A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.	GP00000010	ABCC11 Q96J66	Physiology	1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette	Homo sapiens human - (species)	Homo sapiens human - (species)		ABCC11	Homo sapiens human - (species)	Published - Accepted by Curator
ABCG2	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Cohen-Zinder M; Seroussi E; Larkin DM ; et al. (2005) Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chr[...] 1 Additional References Olsen HG; Nilsen H; Hayes B (2007) Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of [...]	GP00000015	Abcg2 Q7TMS5	Physiology	Tyr581Ser	Bos taurus cattle - (species)	Bos taurus cattle - (species)		ABCG2	Bos taurus cattle - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000017	ABO P16442	Physiology	Gly268 (group A) <-> Ala (group B)	Homininae (subfamily)	Homininae (subfamily)		ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000018	ABO P16442	Physiology	Leu266 (group A) <-> Met (group B)	Homininae (subfamily)	Homininae (subfamily)		ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993) Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000020	ABO P16442	Physiology	Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function) two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.	Homo sapiens human - (species)	Homo sapiens human - (species)		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000022	ABO P16442	Physiology	1bp change resulting in stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species)		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D		Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	G119S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	G119S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000030	Ace P07140	Physiology	331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D		Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D		Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Fournier D; Bride JM; Hoffmann F ; et al. (1992) Acetylcholinesterase. Two types of modifications confer resistance to insecticide. 1 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000032	Ace P07140	Physiology	Phe368 -> Tyr	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000033	Ace P07140	Physiology	Ile/Val199 -> Thr	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000034	Ace P07140	Physiology	Gly303 -> Ala	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000035	Ace P07140	Physiology	Phe115 -> Ser	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)		Acetylcholinesterase (Ace)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Haymer DS; Wu WJ ; et al. (2006) Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]	GP00000045	Ace P07140	Physiology	2 mutations	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
AEP2	Hybrid Incompatibility (F2 sterility)	Coding, SNP	Saccharomyces bayanus (species)	Domesticated	Linkage Mapping	Lee HY; Chou JY; Cheong L ; et al. (2008) Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast speci[...]	GP00000051	AEP2 P22136	Physiology	The region between aa 348 and aa 496 plays a critical role. When this region was further dissected in the constructs H-AEP2-bcb and H-AEP2-m3; both failed to restore respiration in the Chromosome 13 line. This result suggests that multiple critical mutations have occurred during the functional diversification of Sc-AEP2 and Sb-AEP2. Exact causing mutation(s) not determined	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)		AEP2	Saccharomyces bayanus (species)	Published - Accepted by Curator
AGAMOUS-Like6	Plant architecture Inflorescence architecture	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Huang X; Effgen S; Meyer RC ; et al. (2012) Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in[...]	GP00000053	AGL6 P29386	Morphology Morphology	Pro201Leu	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AGAMOUS-Like6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Coding, SNP N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000056	Asip Q03288	Morphology	Premature stop codon at residue 65 N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies)	Domesticated	Candidate Gene	Berryere TG; Kerns JA; Barsh GS ; et al. (2005) Association of an Agouti allele with fawn or sable coat color in domestic dogs.	GP00000060	Asip Q03288	Morphology	c.244G>T + 248G>A ; p.A82S + p.R83H A82S and R83H in Linkage Disequilibrium a G-to-T transversion and a G-to-A transition in exon 4 at positions corresponding to residues 244 and 248 of the cDNA sequence It is unknown if one or both substitutions alter Agouti protein function	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies)		Agouti (ASIP)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Kerns JA; Newton J; Berryere TG ; et al. (2004) Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs. 1 Additional References Berryere TG; Kerns JA; Barsh GS (2005) Association of an Agouti allele with fawn or sable coat color in domestic dogs.	GP00000061	Asip Q03288	Morphology	R96C ; g.23393552C>T c.286C>T p.R96C	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		Agouti (ASIP)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Panthera pardus leopard - (species) D	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000065	Asip Q03288	Morphology	nonsense mutation located in exon 4 (C333A) predicted to introduce a stop codon at amino acid position 111 N	Panthera pardus leopard - (species)	Panthera pardus leopard - (species) D		Agouti	Panthera pardus leopard - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP	Catopuma temminckii Asiatic golden cat - (species)	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000066	Asip Q03288	Morphology	C128W (384C>G)	Catopuma temminckii Asiatic golden cat - (species)	Catopuma temminckii Asiatic golden cat - (species)		Agouti	Catopuma temminckii Asiatic golden cat - (species)	Published - Accepted by Curator
AIM22	F2 lethality	Coding, SNP	Saccharomyces bayanus (species)	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000073	AIM22 P47051	Physiology	Several candidate non-synonymous changes - exact causing mutation(s) unknown	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)		AIM22	Saccharomyces bayanus (species)	Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)	Xenobiotic resistance (alcohol)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Li H; Mukherjee N; Soundararajan U ; et al. (2007) Geographically separate increases in the frequency of the derived ADH1B47His allele in eastern and [...] 1 Additional References Li H; Mukherjee N; Soundararajan U (2007)* Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]	GP00000077	ADH1B P00325	Physiology	Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication	Homo sapiens human - (species)	Homo sapiens human - (species) D		alcohol dehydrogenase (ADH1B)	Homo sapiens human - (species)	Published - Accepted by Curator
Alk / Starch Synthase II	Grain cooking texture	4 Mutations: Coding SNP	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Umemoto T; Yano M; Satoh H ; et al. (2002) Mapping of a gene responsible for the difference in amylopectin structure between japonica-type and [...] 2 Additional References Nakamura Y; Francisco PB; Hosaka Y (2005) Essential amino acids of starch synthase IIa differentiate amylopectin structure and starch quality [...] Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000078	SSII-3 Q0DDE3	Physiology	4 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Alk / Starch Synthase II	Oryza sativa rice - (species)	Published - Accepted by Curator
AMN1	Cell separation	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Yvert G; Brem RB; Whittle J ; et al. (2003) Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.	GP00000082	AMN1 P38285	Physiology	D368V	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		AMN1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000091	AN2 A4GRU8	Morphology	W196* N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000093	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000094	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
APOE (apolipoprotein E)	Aging	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000099	APOE P02649	Physiology	Cys112Arg	Homo sapiens human - (species)	Homo sapiens human - (species)		APOE (apolipoprotein E)	Homo sapiens human - (species)	Published - Accepted by Curator
APSR	Sulfate content (shoot)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007) Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.	GP00000100	APR2 P92981	Physiology	A399E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		APSR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Kit ligand	Coloration (coat)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Seitz JJ; Schmutz SM; Thue TD ; et al. (1999) A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and[...]	GP00000101	KITLG P21583	Morphology	Ala193Asp ; missense mutation at position 654 (nucleotide change not reported) N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Kit ligand	Bos taurus cattle - (species)	Published - Accepted by Curator
ARHGAP15	Pathogen resistance (Trypanosoma)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Noyes H; Brass A; Obara I ; et al. (2011) Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]	GP00000103	Arhgap15 Q811M1	Physiology	H282P	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		ARHGAP15	Bos taurus cattle - (species)	Published - Accepted by Curator
ASP1	Acetic acid production	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Marullo P; Aigle M; Bely M ; et al. (2007) Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cere[...]	GP00000104	APS1 P35181	Physiology	Asp142His	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		ASP1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000117	GA20OX1 Q39110	Morphology	W46* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...] 1 Additional References Xu YL; Li L; Wu K (1995) The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cl[...]	GP00000118	GA20OX1 Q39110	Morphology	W271* -G816A according to Fig.3 of Xu et al. 1995 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000119	GA20OX1 Q39110	Morphology	E312* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000120	GA20OX1 Q39110	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism) Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000121	GA20OX1 Q39110	Morphology Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000122	GA20OX1 Q39110	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000123	GA20OX1 Q39110	Morphology	Splice Site mutation G742A	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ATR13	Pathogenicity	Coding, SNP	Hyaloperonospora parasitica (species)	Intraspecific	Linkage Mapping	Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004) Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. 1 Additional References Allen RL; Meitz JC; Baumber RE (2008) Natural variation reveals key amino acids in a downy mildew effector that alters recognition specifi[...]	GP00000128	Atr13 Q5G7K8	Physiology	Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown	Hyaloperonospora parasitica (species)	Hyaloperonospora parasitica (species)		ATR13	Hyaloperonospora parasitica (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Juwattanasomran R; Somta P; Chankaew S ; et al. (2011) A SNP in GmBADH2 gene associates with fragrance in vegetable soybean variety "Kaori" and SNAP marker[...]	GP00000133	BADH2 Q84LK3	Physiology	1 amino-acid substitution in conserved enzymatic domain	Glycine max soybean - (species)	Glycine max soybean - (species)		BADH2	Glycine max soybean - (species)	Published - Accepted by Curator
BCMA	Glucosinolate content Herbivore resistance	3 Mutations:	Boechera stricta (species)	Intraspecific	Linkage Mapping	Prasad KV; Song BH; Olson-Manning C ; et al. (2012) A gain-of-function polymorphism controlling complex traits and fitness in nature.	GP00000136	J9QWI9	Physiology Physiology	3 mutations	Boechera stricta (species)	Boechera stricta (species)		BCMA	Boechera stricta (species)	Published - Accepted by Curator
BCMO1	Carotenoid content	2 Mutations: Cis-regulatory SNP	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Le Bihan-Duval E; Nadaf J; Berri C ; et al. (2011) Detection of a Cis [corrected] eQTL controlling BCMO1 gene expression leads to the identification of[...]	GP00000137	BCO1 Q9HAY6	Morphology; Physiology	2 mutations	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		BCMO1	Gallus gallus chicken - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content	Coding, SNP N	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Berry SD; Davis SR; Beattie EM ; et al. (2009) Mutation in bovine beta-carotene oxygenase 2 affects milk color. 1 Additional References Tian R; Pitchford WS; Morris CA (2010) Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colou[...]	GP00000138	BCO2 Q9BYV7	Physiology	Substitution creating premature Stop (codon 79) N	Bos taurus cattle - (species)	Bos taurus cattle - (species)		BCO2 = beta-carotene oxygenase 2	Bos taurus cattle - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content	Coding, SNP N	Ovis aries sheep - (species)	Domesticated	Candidate Gene	Våge DI; Boman IA (2010) A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumula[...]	GP00000140	BCO2 Q9BYV7	Physiology	Substitution creating premature Stop (codon 66) N	Ovis aries sheep - (species)	Ovis aries sheep - (species)		BCO2 = beta-carotene oxygenase 2	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP receptor IB (BMPRIB)	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Mulsant P; Lecerf F; Fabre S ; et al. (2001) Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Bo[...]	GP00000146	BMPR-IB Q9BDI4	Physiology	Q259R	Ovis aries sheep - (species)	Ovis aries sheep - (species)		BMP receptor IB (BMPRIB)	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000147	Bmp15 Q9Z0L4	Physiology	Q23*; CAG - > TAG N	Ovis aries sheep - (species)	Ovis aries sheep - (species)		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000148	Bmp15 Q9Z0L4	Physiology	V31D; in a very conserved region across other animals	Ovis aries sheep - (species)	Ovis aries sheep - (species)		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00000149	Bmp15 Q9Z0L4	Physiology	T317I	Ovis aries sheep - (species)	Ovis aries sheep - (species)		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00000150	Bmp15 Q9Z0L4	Physiology	N337H	Ovis aries sheep - (species)	Ovis aries sheep - (species)		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP3 or PRKG2	Cranio-facial morphology	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Schoenebeck JJ; Hutchinson SA; Byers A ; et al. (2012) Variation of BMP3 contributes to dog breed skull diversity.	GP00000152	Bmp3 Q8BHE5	Morphology	F452L in BMP3 ; this missense mutation is in a conserved position and correlates well with small breeds. However; the functional data (zebrafish BMP3 morpholino knockdown) proposed in this article is inconsistent with the mice BMP3 null-mutation	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		BMP3 or PRKG2	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
BRANCHED1a (BRC1a)	Plant architecture Inflorescence architecture	Coding, SNP	Solanum (genus) D	Intergeneric or Higher	Candidate Gene	Nicolas M; Rodríguez-Buey ML; Franco-Zorrilla JM ; et al. (2015) A Recently Evolved Alternative Splice Site in the BRANCHED1a Gene Controls Potato Plant Architecture[...]	GP00000156	BRC1A F6KB94	Morphology Morphology	Evolution of an alternative splice site (G>A) that unlocks a short isoform	Capsicum annuum (species)	Solanum (genus) D		BRANCHED1a (BRC1a)	Solanum (genus)	Published - Accepted by Curator
Brevis radix (BRX)	Root size (shorter)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Mouchel CF; Briggs GC; Hardtke CS (2004) Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell prolifer[...]	GP00000157	BRX Q17TI5	Morphology	premature stop codon in exon 4; TGG>TGA; truncated protein missing approximately two-thirds of the C terminus N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BUL2	Telomere length Aging	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Kwan EX; Foss E; Kruglyak L ; et al. (2011) Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and tel[...]	GP00000166	BUL2 Q03758	Physiology Physiology	Leu883Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		BUL2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Callipyge (CLPG1)	Muscular mass (with paternal effect)	Cis-regulatory, SNP	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Takeda H; Caiment F; Smit M ; et al. (2006) The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis. 5 Additional References Freking BA; Murphy SK; Wylie AA (2002) Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the onl[...] Murphy SK; Nolan CM; Huang Z (2006) Callipyge mutation affects gene expression in cis: a potential role for chromatin structure. Smit M; Segers K; Carrascosa LG (2003) Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism o[...] Georges M; Charlier C; Cockett N (2003) The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes. Gao YQ; Chen X; Wang P (2015) Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar [...]	GP00000168	DIO3 Q6DN07	Morphology	1bp change in the regulatory region of the DLK1-GTL2 imprinted gene cluster	Ovis aries sheep - (species)	Ovis aries sheep - (species)		Callipyge (CLPG1)	Ovis aries sheep - (species)	Published - Accepted by Curator
catechol-O-methyltransferase (COMT)	Pain sensitivity	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Nackley AG; Shabalina SA; Tchivileva IE ; et al. (2006) Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary[...]	GP00000171	COMT P21964	Behavior	G/C - The synonymous mutation(s) affect mRNA stability and loop structures	Homo sapiens human - (species)	Homo sapiens human - (species)		catechol-O-methyltransferase (COMT)	Homo sapiens human - (species)	Published - Accepted by Curator
Cauliflower (BoCAL)	Inflorescence morphology	Coding, SNP N	Brassica oleracea var. botrytis (varietas) D	Domesticated	Candidate Gene	Kempin SA; Savidge B; Yanofsky MF (1995) Molecular basis of the cauliflower phenotype in Arabidopsis. 1 Additional References Purugganan MD; Boyles AL; Suddith JI (2000) Variation and selection at the CAULIFLOWER floral homeotic gene accompanying the evolution of domest[...]	GP00000173	CAL Q39081	Morphology	GAG>TAG; E151*; protein truncated after only 150 of the 255 amino acids of the wild-type protein N	Brassica oleracea wild cabbage - (species)	Brassica oleracea var. botrytis (varietas) D		Cauliflower (BoCAL)	Brassica oleracea var. botrytis (varietas)	Published - Accepted by Curator
CENTRORADIALIS (HvCEN)	Flowering time Seasonal growth	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Comadran J; Kilian B; Russell J ; et al. (2012) Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and [...]	GP00000179	CEN Q9ZNV5	Physiology Physiology	P135A	Hordeum vulgare (species)	Hordeum vulgare (species)		CENTRORADIALIS (HvCEN)	Hordeum vulgare (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Erinaceus concolor southern white-breasted hedgehog - (species) D Erinaceus europaeus western European hedgehog - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00000183	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Erinaceus concolor southern white-breasted hedgehog - (species) D Erinaceus europaeus western European hedgehog - (species) D		CHRNA1	Erinaceus concolor southern white-breasted hedgehog - (species) Erinaceus europaeus western European hedgehog - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Mellivora capensis ratel - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00000184	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Mellivora capensis ratel - (species) D		CHRNA1	Mellivora capensis ratel - (species)	Published - Accepted by Curator
CmACS-7	Flower sex determination (male organs)	Coding, SNP	Cucumis melo muskmelon - (species)	Domesticated	Linkage Mapping	Boualem A; Fergany M; Fernandez R ; et al. (2008) A conserved mutation in an ethylene biosynthesis enzyme leads to andromonoecy in melons.	GP00000187	ACS7 Q9STR4	Physiology	A57V	Cucumis melo muskmelon - (species)	Cucumis melo muskmelon - (species)		CmACS-7	Cucumis melo muskmelon - (species)	Published - Accepted by Curator
Couch potato	Diapause	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Schmidt PS; Zhu CT; Das J ; et al. (2008) An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]	GP00000191	cpo Q01617	Physiology	Ile462Lys	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Couch potato	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele	Flowering time Fruit shape (fruit length) Flower morphology (ovule number per fruit) Fertility (percentage of unfertilized ovules)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001) A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2. 3 Additional References Olsen KM; Halldorsdottir SS; Stinchcombe JR (2004) Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. el-Assal SE; Alonso-Blanco C; Hanhart CJ (2004) Pleiotropic effects of the Arabidopsis cryptochrome 2 allelic variation underlie fruit trait-related[...] Botto JF; Alonso-Blanco C; Garzarón I (2003) The Cape Verde Islands allele of cryptochrome 2 enhances cotyledon unfolding in the absence of blue [...]	GP00000192	CRY2 Q96524	Physiology Morphology Morphology Physiology	V367M	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Cryptochrome 2 (CRY2) EDI allele	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CYC8	Salt tolerance (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000195	CYC8 P14922	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		CYC8	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CYP1A2	Enzymatic activity	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Murayama N; Soyama A; Saito Y ; et al. (2004) Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]	GP00000199	CYP1A2 P05177	Physiology	F186L	Homo sapiens human - (species)	Homo sapiens human - (species) D		CYP1A2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP2C9	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000200	CYP2C9 P11712	Physiology	I359L	Homo sapiens human - (species)	Homo sapiens human - (species)		CYP2C9	Homo sapiens human - (species)	Published - Accepted by Curator
CYP4F2	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000203	CYP4F2 P78329	Physiology	V433M	Homo sapiens human - (species)	Homo sapiens human - (species)		CYP4F2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP6AB3	Xenobiotic resistance (imperatorin)	Coding, SNP	Depressaria pastinacella (species)	Intraspecific	Candidate Gene	Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007) Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]	GP00000204	CYP6AB3 Q7YZS3	Physiology	Ala92Val (and potentiallly 4 other a.a. substitutions)	Depressaria pastinacella (species)	Depressaria pastinacella (species)		CYP6AB3	Depressaria pastinacella (species)	Published - Accepted by Curator
CYP6B1	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio polyxenes black swallowtail - (species)	Interspecific	Candidate Gene	Li W; Schuler MA; Berenbaum MR (2003) Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Sp[...]	GP00000205	CYP6B1 Q04552	Physiology Physiology	Ile484Phe and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio polyxenes black swallowtail - (species)		CYP6B1	Papilio polyxenes black swallowtail - (species)	Published - Accepted by Curator
CYP6B4	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio glaucus eastern tiger swallowtail - (species)	Intergeneric or Higher	Candidate Gene	Mao W; Schuler MA; Berenbaum MR (2007) Cytochrome P450s in Papilio multicaudatus and the transition from oligophagy to polyphagy in the Pap[...]	GP00000206	CYP6B4 Q27902	Physiology Physiology	Lys484Ser and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio glaucus eastern tiger swallowtail - (species)		CYP6B4	Papilio glaucus eastern tiger swallowtail - (species)	Published - Accepted by Curator
diacylglycerol acyltransferase 1 (DGAT1)	Milk fat content	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Grisart B; Coppieters W; Farnir F ; et al. (2002) Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the [...] 1 Additional References Grisart B; Farnir F; Karim L (2004) Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotid[...]	GP00000222	Dgat1 Q9Z2A7	Physiology	K232A	Bos taurus cattle - (species)	Bos taurus cattle - (species)		diacylglycerol acyltransferase 1 (DGAT1)	Bos taurus cattle - (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (flowers)	Coding, SNP	Iochroma cyaneum (species)	Intraspecific	Linkage Mapping	Smith SD; Rausher MD (2011) Gene loss and parallel evolution contribute to species difference in flower color.	GP00000225	DFRA P51102	Morphology	12 candidate a.a. substitution in cluding one at a residue known to influence substrate specificity	Iochroma cyaneum (species)	Iochroma cyaneum (species)		dihydroflavonol reductase (DFR)	Iochroma cyaneum (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Unckless RL; Rottschaefer SM; Lazzaro BP (2015) The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster. 1 Additional References Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.	GP00000227	DptA P24492	Physiology	Ser>Arg (AGC>AGA)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Diptericin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila. 1 Additional References Unckless RL; Lazzaro BP (2016) The potential for adaptive maintenance of diversity in insect antimicrobial peptides.	GP00000228	DptA P24492	Physiology	Ser>Arg (AGC>AGG)	Drosophila simulans (species)	Drosophila simulans (species)		Diptericin	Drosophila simulans (species)	Published - Accepted by Curator
DMRT3	Gait (ability to pace)	Coding, SNP N	Equus caballus horse - (species)	Domesticated	Linkage Mapping	Andersson LS; Larhammar M; Memic F ; et al. (2012) Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. 1 Additional References Petersen JL; Mickelson JR; Rendahl AK (2013) Genome-wide analysis reveals selection for important traits in domestic horse breeds.	GP00000230	DMRT3 F6W2R2	Behavior	Premature stop codon (Ser301Stop) resulting in truncated protein: a single base change at nucleotide position chr23:22999655 causing a premature stop at codon 301 in DMRT3 (DMRT3_Ser301STOP). The allele is expected to encode a truncated protein lacking 1 N	Equus caballus horse - (species)	Equus caballus horse - (species)		DMRT3	Equus caballus horse - (species)	Published - Accepted by Curator
DTH2	Flowering time	2 Mutations: Coding SNP	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Wu W; Zheng XM; Lu G ; et al. (2013) Association of functional nucleotide polymorphisms at DTH2 with the northward expansion of rice cult[...]	GP00000239	DTH2 O82118	Physiology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		DTH2	Oryza sativa rice - (species)	Published - Accepted by Curator
Duffy	Pathogen resistance (Plasmodium; malaria parasite) (malaria)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Tournamille C; Colin Y; Cartron JP ; et al. (1995) Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-n[...]	GP00000240	ACKR1 Q16570	Physiology	T to C substitution in 5' region at pos -46	Homo sapiens human - (species)	Homo sapiens human - (species)		Duffy	Homo sapiens human - (species)	Published - Accepted by Curator
EARLY FLOWERING 3/ EARLY MATURITY 8	Flowering time	Coding, SNP N	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Faure S; Turner AS; Gruszka D ; et al. (2012) Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]	GP00000245	ELF3 O82804	Physiology	Premature stop codon; C-to-T point mutation in exon 2 N	Hordeum vulgare (species)	Hordeum vulgare (species)		EARLY FLOWERING 3/ EARLY MATURITY 8	Hordeum vulgare (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	5 Mutations: Cis-regulatory SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Rebeiz M; Pool JE; Kassner VA ; et al. (2009) Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population.	GP00000253	e O76858	Morphology	5 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
EDAR	Ear shape	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Adhikari K; Reales G; Smith AJ ; et al. (2015) A genome-wide association study identifies multiple loci for variation in human ear morphology.	GP00000255	EDAR Q9UNE0	Morphology	Val370Ala	Homo sapiens human - (species)	Homo sapiens human - (species)		EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EDAR	Hair thickness Eccrine gland density	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Fujimoto A; Kimura R; Ohashi J ; et al. (2008) A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickne[...] 1 Additional References Kamberov YG; Wang S; Tan J (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant.	GP00000256	EDAR Q9UNE0	Morphology Morphology	Val370Ala; functionally validated in mouse	Homo sapiens human - (species)	Homo sapiens human - (species) D		EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EDAR	Tooth shape	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kimura R; Yamaguchi T; Takeda M ; et al. (2009) A common variation in EDAR is a genetic determinant of shovel-shaped incisors.	GP00000257	EDAR Q9UNE0	Morphology	Val370Ala	Homo sapiens human - (species)	Homo sapiens human - (species) D		EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 3 Additional References Bigham A; Bauchet M; Pinto D (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...] Xu S; Li S; Yang Y (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans. Xiang K; Ouzhuluobu ; Peng Y (2013) Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high[...]	GP00000261	EGLN1 Q9GZT9	Physiology	possibly D4E	Homo sapiens human - (species)	Homo sapiens human - (species) D		EGLN1	Homo sapiens human - (species)	Published - Accepted by Curator
Ehd1 (Response regulator)	Flowering time	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Doi K; Izawa T; Fuse T ; et al. (2004) Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-[...]	GP00000263	EHD1 Q9H4M9	Physiology	G218R in highly conserved region in GARP domain	Oryza glaberrima African rice - (species)	Oryza sativa rice - (species)		Ehd1 (Response regulator)	Oryza sativa rice - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000267	END3 P39013	Physiology Physiology	S258N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000268	END3 P39013	Physiology Physiology	D268N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Endothelin receptor B	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Metallinos DL; Bowling AT; Rine J (1998) A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome:[...] 2 Additional References Santschi EM; Purdy AK; Valberg SJ (1998) Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses. Yang GC; Croaker D; Zhang AL (1998) A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndr[...]	GP00000269	Ednrb P48302	Morphology	Iso118Lys	Equus caballus horse - (species)	Equus caballus horse - (species) D		Endothelin receptor B	Equus caballus horse - (species)	Published - Accepted by Curator
Endothelin receptor B	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Miwa M; Inoue-Murayama M; Aoki H ; et al. (2007) Endothelin receptor B2 (EDNRB2) is associated with the panda plumage colour mutation in Japanese qua[...]	GP00000270	Ednrb P48302	Morphology	Arg332His	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)		Endothelin receptor B	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)	Increase in antiviral ribonuclease activity	Coding, SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Zhang J; Rosenberg HF (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.	GP00000272	RNASE2 P10153	Physiology	Arg64Ser	Primates (order)	Catarrhini (parvorder)		eosinophil-derived neurotoxin (EDN)	Catarrhini (parvorder)	Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)	Increase in antiviral ribonuclease activity	Coding, SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Zhang J; Rosenberg HF (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.	GP00000273	RNASE2 P10153	Physiology	Thr132Arg	Primates (order)	Catarrhini (parvorder)		eosinophil-derived neurotoxin (EDN)	Catarrhini (parvorder)	Published - Accepted by Curator
EphB2	Feathers (crest morphology)	Coding, SNP	Columba livia rock pigeon - (species) D	Domesticated	Association Mapping	Shapiro MD; Kronenberg Z; Li C ; et al. (2013) Genomic diversity and evolution of the head crest in the rock pigeon. 1 Additional References Vickrey AI; Domyan ET; Horvath MP (2015) Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Misse[...]	GP00000275	EPHB2 P28693	Morphology	Arg758Cys (C>T)	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		EphB2	Columba livia rock pigeon - (species)	Published - Accepted by Curator
EphB2	Feathers (crest morphology)	Coding, SNP	Streptopelia risoria ringneck dove - (species) D	Domesticated	Candidate Gene	Vickrey AI; Domyan ET; Horvath MP ; et al. (2015) Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Misse[...]	GP00000276	EPHB2 P28693	Morphology	Gly636Arg (G>A)	Streptopelia risoria ringneck dove - (species)	Streptopelia risoria ringneck dove - (species) D		EphB2	Streptopelia risoria ringneck dove - (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000281	ERG11 P10613	Physiology	Y132H	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000282	ERG11 P10613	Physiology	S405F	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000283	ERG11 P10613	Physiology	G464S	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000284	ERG11 P10613	Physiology	R467K	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000286	ERG3 P32353	Physiology	Arg63Stop A187T in line 21 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG7	Xenobiotic resistance (drug)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000289	ERG7 P38604	Physiology	Phe699Leu	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG7	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Newcomb RD; Campbell PM; Ollis DL ; et al. (1997) A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]	GP00000294	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)		esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Jackson CJ; Liu JW; Carr PD ; et al. (2013) Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]	GP00000295	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)		esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species)	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000296	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species)		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000297	LcaE7 Q25252	Physiology	Trp251Ser	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000298	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E7 = E3	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Claudianos C; Russell RJ; Oakeshott JG (1999) The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]	GP00000299	LcaE7 Q25252	Physiology	Gly137Asp	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		esterase isozyme E7 = E3	Musca domestica house fly - (species)	Published - Accepted by Curator
FAAH	Anxiety (fear reduction)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Dincheva I; Drysdale AT; Hartley CA ; et al. (2015) FAAH genetic variation enhances fronto-amygdala function in mouse and human.	GP00000301	Faah P97612	Behavior	Pro129Thr (C385A; common variant rs324420)	Homo sapiens human - (species)	Homo sapiens human - (species)		FAAH	Homo sapiens human - (species)	Published - Accepted by Curator
FGF5	Hair length (short)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Cadieu E; Neff MW; Quignon P ; et al. (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00000310	Fgf5 P15656	Morphology	Cys95Phe	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Fgfr1a1	Fish scales (loss)	Coding, SNP	Cyprinus carpio common carp - (species) D	Domesticated	Candidate Gene	Rohner N; Bercsényi M; Orbán L ; et al. (2009) Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication.	GP00000313	fgfr1a Q90Z00	Morphology	Glu664Lys	Cyprinus carpio common carp - (species)	Cyprinus carpio common carp - (species) D		Fgfr1a1	Cyprinus carpio common carp - (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, SNP	Glycine soja (species)	Intraspecific	Linkage Mapping	Takahashi R; Dubouzet JG; Matsumura H ; et al. (2010) A new allele of flower color gene W1 encoding flavonoid 3'5'-hydroxylase is responsible for light pu[...]	GP00000323	CYP75A2 P37120	Morphology	V210M (uncertain); no expression level differences detected	Glycine soja (species)	Glycine soja (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, SNP	Pisum sativum pea - (species)	Domesticated	Candidate Gene	Moreau C; Ambrose MJ; Turner L ; et al. (2012) The B gene of pea encodes a defective flavonoid 3',5'-hydroxylase, and confers pink flower color.	GP00000326	CYP75A2 P37120	Morphology	G111E	Pisum sativum pea - (species)	Pisum sativum pea - (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Pisum sativum pea - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000330	FLC Q9S7Q7	Physiology	Substitution creating premature Stop (codon 158) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	2 Mutations: Cis-regulatory SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Coustham V; Li P; Strange A ; et al. (2012) Quantitative modulation of polycomb silencing underlies natural variation in vernalization. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000331	FLC Q9S7Q7	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000335	FLC Q9S7Q7	Physiology	GA substitution disrupting Splice Site	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Capsella rubella (species)	Intraspecific	Linkage Mapping	Guo YL; Todesco M; Hagmann J ; et al. (2012) Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella[...]	GP00000337	FLC Q9S7Q7	Physiology	Splice site mutation introducing frameshift; removing the last 35 of 198 amino acids	Capsella rubella (species)	Capsella rubella (species)		FLC (Flowering Locus C)	Capsella rubella (species)	Published - Accepted by Curator
FLC-1	Flowering time	Coding, SNP	Brassica rapa field mustard - (species)	Domesticated	Linkage Mapping	Yuan YX; Wu J; Sun RF ; et al. (2009) A naturally occurring splicing site mutation in the Brassica rapa FLC1 gene is associated with varia[...]	GP00000338	FLC Q9S7Q7	Physiology	GA substitution disrupting Splice Site	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species)		FLC-1	Brassica rapa field mustard - (species)	Published - Accepted by Curator
FoxP2	Gene expression change (transcriptional targets)	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Konopka G; Bomar JM; Winden K ; et al. (2009) Human-specific transcriptional regulation of CNS development genes by FOXP2. 1 Additional References Schreiweis C; Bornschein U; Burguière E (2014) Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural perform[...]	GP00000353	FOXP2 O15409	Behavior	2 aa changes (T303N and N325S) resulting in changes of the regulated transcriptional targets in a human neuron cell line. Speculatively; these changes could be associated with language skills but these connections with null-mutant phenotypes are dubious - whether one or both mutations are required is unknown	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D		FoxP2	Homo sapiens human - (species)	Published - Accepted by Curator
FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pineau C; Loubet S; Lefoulon C ; et al. (2012) Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Z[...]	GP00000355	DTX43 Q9SFB0	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000363	FRI P0DH90	Physiology	Trp240* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000364	FRI P0DH90	Physiology	Glu361* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gazzani S; Gendall AR; Lister C ; et al. (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.	GP00000365	FRI P0DH90	Physiology	K232* in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000373	FRI P0DH90	Physiology	Y162* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000374	FRI P0DH90	Physiology	K170* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 1 (FRL1)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000376	FRL1 Q9FFF1	Physiology	E279* in the middle of the conceptual protein sequence N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida like 1 (FRL1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 2 (FRL2)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000377	FRL2 Q9C6S2	Physiology	A132P and/or L401Q	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida like 2 (FRL2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FTO	Body size (weight; variance)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Frayling TM; Timpson NJ; Weedon MN ; et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and[...] 4 Additional References Dina C; Meyre D; Gallina S (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Scuteri A; Sanna S; Chen WM (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-rela[...] Yang J; Loos RJ; Powell JE (2012) FTO genotype is associated with phenotypic variability of body mass index. Claussnitzer M; Dankel SN; Kim KH (2015) FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.	GP00000378	FTO Q9C0B1	Morphology; Physiology	rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor	Homo sapiens human - (species)	Homo sapiens human - (species)		FTO	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000381	FUT2 Q10981	Physiology	premature stop at codon 143: TGG>TGA N	Homo sapiens human - (species)	Homo sapiens human - (species)		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000382	FUT2 Q10981	Physiology	Ile129Phe	Homo sapiens human - (species)	Homo sapiens human - (species)		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
GCNF (NR6A1)	Vertebrae number	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Mikawa S; Morozumi T; Shimanuki S ; et al. (2007) Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan n[...]	GP00000386	Nr6a1 Q64249	Morphology	Pro192Leu	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		GCNF (NR6A1)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Candidate Gene	Silva BD; Castro EA; Souza CJ ; et al. (2011) A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increas[...]	GP00000390	GDF9 O60383	Physiology	F345C	Ovis aries sheep - (species)	Ovis aries sheep - (species)		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Nicol L; Bishop SC; Pong-Wong R ; et al. (2009) Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility i[...]	GP00000391	GDF9 O60383	Physiology	S109R	Ovis aries sheep - (species)	Ovis aries sheep - (species)		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
GIGANTEA	Photoperiod response Circadian rhythm	Coding, SNP	Brassica rapa field mustard - (species)	Domesticated	Linkage Mapping	Xie Q; Lou P; Hermand V ; et al. (2015) Allelic polymorphism of GIGANTEA is responsible for naturally occurring variation in circadian perio[...]	GP00000396	GI Q9SQI2	Physiology Physiology	Ser264Ala	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species)		GIGANTEA	Brassica rapa field mustard - (species)	Published - Accepted by Curator
GL3.1	Grain size	2 Mutations: Coding SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Qi P; Lin YS; Song XJ ; et al. (2012) The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;[...]	GP00000397	GL3 Q9FN69	Morphology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		GL3.1	Oryza sativa rice - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000401	G6PD P11413	Physiology	Ser188Phe C>T	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Louicharoen C; Patin E; Paul R ; et al. (2009) Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.	GP00000402	G6PD P11413	Physiology	Ser163Gly	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000403	G6PD P11413	Physiology	Val68Met G>A at nucleotide position 376 in exon 5 - OMIM code +305900.0002	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-dependent insulinotropic polypeptide	Glycemia Adipolysis rate	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Chang CL; Cai JJ; Lo C ; et al. (2011) Adaptive selection of an incretin gene in Eurasian populations.	GP00000404	GIP P09681	Physiology Physiology	Ser103Gly	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-dependent insulinotropic polypeptide	Homo sapiens human - (species)	Published - Accepted by Curator
GPA1	Pheromone response Cell elongation	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Yvert G; Brem RB; Whittle J ; et al. (2003) Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. 1 Additional References Nogami S; Ohya Y; Yvert G (2007) Genetic complexity and quantitative trait loci mapping of yeast morphological traits.	GP00000410	GPA1 P08539	Physiology Physiology	Ser469Ile	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		GPA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Growth Hormone Receptor	Body size (height)	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000415	GHR P10912	Morphology	Arg61* N	Homo sapiens human - (species)	Homo sapiens human - (species)		Growth Hormone Receptor	Homo sapiens human - (species)	Published - Accepted by Curator
Growth Hormone Receptor	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Viitala S; Szyda J; Blott S ; et al. (2006) The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...] 1 Additional References Rahmatalla SA; Müller U; Strucken EM (2011) The F279Y polymorphism of the GHR gene and its relation to milk production and somatic cell score in[...]	GP00000416	Ghr P16882	Physiology	Phe279Tyr	Bos taurus cattle - (species)	Bos taurus cattle - (species)		Growth Hormone Receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
GS3	Grain size	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Fan C; Xing Y; Mao H ; et al. (2006) GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, en[...] 1 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000417	GS3 C6L686	Morphology	C55*;TGC>TGA causing a 178-aa truncation in the C-terminus of the predicted protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		GS3	Oryza sativa rice - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000426	ABCA2 A0A0S0G7V0	Physiology	Pro53* (161T>A) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Hd6a	Flowering time	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Takahashi Y; Shomura A; Sasaki T ; et al. (2001) Hd6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the alpha subunit [...]	GP00000442	HD6 Q9AR27	Physiology	K91*; AAG>TAG N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Hd6a	Oryza sativa rice - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000443	HMA3 P0CW78	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Ueno D; Yamaji N; Kono I ; et al. (2010) Gene limiting cadmium accumulation in rice.	GP00000445	HMA3 P0CW78	Physiology	H80R	Oryza sativa rice - (species)	Oryza sativa rice - (species)		heavy metal atpase3 (HMA3)	Oryza sativa rice - (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000450	HMA5 Q9SH30	Physiology	P626L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000451	HMA5 Q9SH30	Physiology	N923T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000452	hecw-1 G5EEJ0	Behavior	Y322C	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000453	hecw-1 G5EEJ0	Behavior	Q325P	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
hemoglobin; HBA	Hypoxia response	Coding, SNP	Lama (genus)	Interspecific	Candidate Gene	Kleinschmidt T; März J; Jürgens KD ; et al. (1986) Interaction of allosteric effectors with alpha-globin chains and high altitude respiration of mammal[...]	GP00000454	HBA1 P69905	Physiology	Asp122His	Mammalia mammals - (class)	Lama (genus)		hemoglobin; HBA	Lama (genus)	Published - Accepted by Curator
hemoglobin; HBA and HBB	Hypoxia response	Coding, SNP	Crocodylus niloticus Nile crocodile - (species)	Intergeneric or Higher	Candidate Gene	Komiyama NH; Miyazaki G; Tame J ; et al. (1995) Transplanting a unique allosteric effect from crocodile into human haemoglobin.	GP00000455	HBA1 P69905	Physiology	No more than 12 amino acid substitutions required for providing crocodile-like properties in engineered human Hb - effect of single amino acid changes not tested	Homo sapiens human - (species)	Crocodylus niloticus Nile crocodile - (species)		hemoglobin; HBA and HBB	Crocodylus niloticus Nile crocodile - (species)	Published - Accepted by Curator
hemoglobin; HBA-T1 and T2 paralogues	Hypoxia response	5 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Sabatino SJ; Hoffmann FG ; et al. (2007) The molecular basis of high-altitude adaptation in deer mice. 2 Additional References Storz JF; Kelly JK (2008) Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights [...] Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000456	HBA1 P69905	Physiology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		hemoglobin; HBA-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas cyanoptera cinnamon teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000457	HBA1 P69905	Physiology	Asn9Ser	Anas cyanoptera cinnamon teal - (species)	Anas cyanoptera cinnamon teal - (species) D		hemoglobin; HBA2	Anas cyanoptera cinnamon teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000458	HBA1 P69905	Physiology	Ala77Thr	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000459	HBAD P02001	Physiology	Ser130Phe	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000460	HBA1 P69905	Physiology	Ala77Thr	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000461	HBAD P02001	Physiology	Val96Ala	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anser indicus bar-headed goose - (species) D	Interspecific	Candidate Gene	Jessen TH; Weber RE; Fermi G ; et al. (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...] 2 Additional References McCracken KG; Barger CP; Bulgarella M (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. McCracken KG; Barger CP; Sorenson MD (2010) Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin gen[...]	GP00000462	HBA1 P69905	Physiology	Pro119Ala	Anser anser domestic goose - (species)	Anser indicus bar-headed goose - (species) D		hemoglobin; HBA2	Anser indicus bar-headed goose - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000463	HBA1 P69905	Physiology	Ala5Thr	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBA2	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Merganetta armata (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000464	HBA1 P69905	Physiology	Ala77Thr	Merganetta armata (species)	Merganetta armata (species) D		hemoglobin; HBA2	Merganetta armata (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	2 Mutations: Coding SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000465	HBAD P02001	Physiology	2 mutations	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBA2	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Pathogen resistance (Plasmodium; malaria parasite)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Jallow M; Teo YY; Small KS ; et al. (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa.	GP00000466	HBB P68871	Physiology	Glu6Val	Homo sapiens human - (species)	Homo sapiens human - (species) D		hemoglobin; HBB	Homo sapiens human - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000467	HBB P68871	Physiology	2 mutations	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBB	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas georgica yellow-billed pintail - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000468	HBB P68871	Physiology	2 mutations	Anas georgica yellow-billed pintail - (species)	Anas georgica yellow-billed pintail - (species) D		hemoglobin; HBB	Anas georgica yellow-billed pintail - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas puna (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000469	HBB P68871	Physiology	2 mutations	Anas ducks - (genus)	Anas puna (species) D		hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Lophonetta specularioides crested duck - (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000470	HBB P68871	Physiology	2 mutations	Anatidae waterfowl - (family)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000471	HBB P68871	Physiology	Asp94Glu	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000472	HBB P68871	Physiology	Asp94Glu	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Jessen TH; Weber RE; Fermi G ; et al. (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...] 2 Additional References McCracken KG; Barger CP; Bulgarella M (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. McCracken KG; Barger CP; Sorenson MD (2010) Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin gen[...]	GP00000473	HBB P68871	Physiology	Leu55Ser	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000474	HBB P68871	Physiology	Ala86Ser	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	3 Mutations: Coding SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000475	HBA1 P69905	Physiology	3 mutations	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB-T1 and T2 paralogues	Hypoxia response	4 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Runck AM; Sabatino SJ ; et al. (2009) Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer [...] 1 Additional References Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000476	HBB P68871	Physiology	4 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		hemoglobin; HBB-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBB/HBD fusion gene	Temperature tolerance (cold)	3 Mutations: Coding SNP	Mammuthus primigenius woolly mammoth - (species)	Intergeneric or Higher	Candidate Gene	Campbell KL; Roberts JE; Watson LN ; et al. (2010) Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance[...]	GP00000477	HBB P68871	Physiology	3 mutations	Elephantidae elephants - (family)	Mammuthus primigenius woolly mammoth - (species)		hemoglobin; HBB/HBD fusion gene	Mammuthus primigenius woolly mammoth - (species)	Published - Accepted by Curator
HUA2	Flowering time Shoot morphology	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Wang Q; Sajja U; Rosloski S ; et al. (2007) HUA2 caused natural variation in shoot morphology of A. thaliana.	GP00000491	HUA2 Q9XER9	Physiology Morphology	K525E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Human Leukocyte Antigen-B (HLA-B)	Pathogen resistance (HIV control)	5 Mutations: Coding SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	; Pereyra F; Jia X ; et al. (2010) The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.	GP00000492	HLA-B P01889	Physiology	5 mutations	Homo sapiens human - (species)	Homo sapiens human - (species)		Human Leukocyte Antigen-B (HLA-B)	Homo sapiens human - (species)	Published - Accepted by Curator
IL4	Immune response	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Linkage Mapping	Rockman MV; Hahn MW; Soranzo N ; et al. (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression.	GP00000497	IL4 P05112	Physiology	_524T promoter single base-pair substitution affecting binding of the NFAT transcription factor	Homo sapiens human - (species)	Homo sapiens human - (species)		IL4	Homo sapiens human - (species)	Published - Accepted by Curator
IME1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00000498	IME1 P21190	Physiology	L325M and/or 1bp synonymous substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		IME1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Insulin-like growth factor 2 (IGF2)	Muscular mass Fat deposition Heart size	Cis-regulatory, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Van Laere AS; Nguyen M; Braunschweig M ; et al. (2003) A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.	GP00000502	Igf2 P09535	Morphology Physiology Morphology	1bp change	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		Insulin-like growth factor 2 (IGF2)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
interleukin-4	Immune response	Cis-regulatory, SNP	Homo sapiens human - (species)	Interspecific	Candidate Gene	Rockman MV; Hahn MW; Soranzo N ; et al. (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression.	GP00000504	IL4R P24394	Physiology	1bp substitution in promoter	Primates (order)	Homo sapiens human - (species)		interleukin-4	Homo sapiens human - (species)	Published - Accepted by Curator
Isocitrate dehydrogenase (NADP) (IDH)	Temperature tolerance (temperature range)	2 Mutations: Coding SNP	Mytilus trossulus common blue mussel - (species)	Interspecific	Candidate Gene	Lockwood BL; Somero GN (2012) Functional determinants of temperature adaptation in enzymes of cold- versus warm-adapted mussels (G[...]	GP00000506	I1VYX2	Physiology	2 mutations	Mytilus galloprovincialis Mediterranean mussel - (species)	Mytilus trossulus common blue mussel - (species)		Isocitrate dehydrogenase (NADP) (IDH)	Mytilus trossulus common blue mussel - (species)	Published - Accepted by Curator
KCS18	Oil composition	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jasinski S; Lécureuil A; Miquel M ; et al. (2012) Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]	GP00000512	FAE1 Q38860	Physiology	L407V N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		KCS18	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Brooks SA; Bailey E (2005) Exon skipping in the KIT gene causes a Sabino spotting pattern in horses.	GP00000515	Kit P05532	Morphology	T->A in intron 16; leads to skipping of exon 17	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP N	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00000516	Kit P05532	Morphology	Y717* N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Felis catus domestic cat - (species) D	Domesticated	Association Mapping	Montague MJ; Li G; Gandolfi B ; et al. (2014) Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology[...]	GP00000518	Kit P05532	Morphology	Two nucleotide changes affecting site 3 of codon 345 and site 1 of codon 346 - resulting in Glu345Asp + His346Asn c. 1035_1036delinsCA GAGCAY > GACAAY	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		Kit (type III receptor protein-tyrosine kinase)	Felis catus domestic cat - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	2 Mutations:	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Marklund S; Kijas J; Rodriguez-Martinez H ; et al. (1998) Molecular basis for the dominant white phenotype in the domestic pig. 1 Additional References Rubin CJ; Megens HJ; Martinez Barrio A (2012) Strong signatures of selection in the domestic pig genome.	GP00000520	Kit P05532	Morphology	2 mutations	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		Kit (type III receptor protein-tyrosine kinase)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Vulpes vulpes red fox - (species) D	Domesticated	Linkage Mapping	Johnson JL; Kozysa A; Kharlamova AV ; et al. (2015) Platinum coat color in red fox (Vulpes vulpes) is caused by a mutation in an autosomal copy of KIT.	GP00000521	Kit P05532	Morphology	splice mutation; G to A substitution in the first nucleotide of intron 17; leads to skipping of exon 17.	Vulpes vulpes red fox - (species)	Vulpes vulpes red fox - (species) D		Kit (type III receptor protein-tyrosine kinase)	Vulpes vulpes red fox - (species)	Published - Accepted by Curator
KRT71	Hair type (curly)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Cadieu E; Neff MW; Quignon P ; et al. (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00000524	Krt71 Q9R0H5	Morphology	c.451A>T in exon 2 - Arg151Trp	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		KRT71	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
KRT71	Hair type (curly and hairless)	2 Mutations: Coding	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Gandolfi B; Outerbridge CA; Beresford LG ; et al. (2010) The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.	GP00000525	Krt71 Q9R0H5	Morphology	2 mutations	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		KRT71	Felis catus domestic cat - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Linkage Mapping	Enattah NS; Sahi T; Savilahti E ; et al. (2002) Identification of a variant associated with adult-type hypolactasia. 1 Additional References Tishkoff SA; Reed FA; Ranciaro A (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000529	LCT P09848	Physiology	C-13910T	Homo sapiens human - (species)	Homo sapiens human - (species)		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000530	LCT P09848	Physiology	C-13907G	Homo sapiens human - (species)	Homo sapiens human - (species)		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000531	LCT P09848	Physiology	T-13915G	Homo sapiens human - (species)	Homo sapiens human - (species) D		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe. 1 Additional References Breton G; Schlebusch CM; Lombard M (2014) Lactase persistence alleles reveal partial East African ancestry of southern African Khoe pastoralis[...]	GP00000532	LCT P09848	Physiology	G14010C ; In Khoe Pastoralist group lactase persistence (LP)-regulatory region 2 SNPs with greatest frequencies 13910C>T and 14010G>C	Homo sapiens human - (species)	Homo sapiens human - (species)		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intergeneric or Higher	Candidate Gene	Wood KV; Lam YA; Seliger HH ; et al. (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors.	GP00000552	P08659	Physiology	several nucleotide substitutions leading to several amino acid changes -exact amino acid changes unknown	Photinus pyralis common eastern firefly - (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000553	P08659	Physiology	T739G and C740G in exon 4; leading to one amino acid change - colour difference between the yellow- and orange-emitting luciferases is due entirely to S247G	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	2 Mutations: Coding SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000554	P08659	Physiology	2 mutations	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Opisthocomus hoazin (species) D	Intergeneric or Higher	Candidate Gene	Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.	GP00000556	LYZ1 P04421	Physiology	5 mutations	Aves birds - (class)	Opisthocomus hoazin (species) D		lysozyme	Opisthocomus hoazin (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Bos taurus cattle - (species)	Intergeneric or Higher	Candidate Gene	Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2) Adaptive evolution in the stomach lysozymes of foregut fermenters. 1 Additional References Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.	GP00000557	LYZ1 P04421	Physiology	5 mutations	Mammalia mammals - (class)	Bos taurus cattle - (species)		lysozyme	Bos taurus cattle - (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Colobinae (subfamily)	Intergeneric or Higher	Candidate Gene	Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2) Adaptive evolution in the stomach lysozymes of foregut fermenters. 3 Additional References Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin. Swanson KW; Irwin DM; Wilson AC (1991) Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection. Messier W; Stewart CB (1997) Episodic adaptive evolution of primate lysozymes.	GP00000558	LYZ1 P04421	Physiology	5 mutations	Primates (order)	Colobinae (subfamily)		lysozyme	Colobinae (subfamily)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, SNP	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000568	MC1R Q01726	Morphology	Arg164Cys (position 160 in human; so this mutation resembles the human R160W hypomorphic human mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Vulpes lagopus Arctic fox - (species)	Intraspecific	Candidate Gene	Våge DI; Fuglei E; Snipstad K ; et al. (2005) Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) [...]	GP00000569	MC1R Q01726	Morphology	G5C	Vulpes lagopus Arctic fox - (species)	Vulpes lagopus Arctic fox - (species)		MC1R	Vulpes lagopus Arctic fox - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Vulpes lagopus Arctic fox - (species)	Intraspecific	Candidate Gene	Våge DI; Fuglei E; Snipstad K ; et al. (2005) Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) [...]	GP00000570	MC1R Q01726	Morphology	F280C	Vulpes lagopus Arctic fox - (species)	Vulpes lagopus Arctic fox - (species)		MC1R	Vulpes lagopus Arctic fox - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Candidate Gene	Klungland H; Våge DI; Gomez-Raya L ; et al. (1995) The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination.	GP00000572	MC1R Q01726	Morphology	L99P ; presumably constitutively active	Bos taurus cattle - (species)	Bos taurus cattle - (species)		MC1R	Bos taurus cattle - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies)	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Ellinwood NM ; et al. (2003 Jan-Feb) MC1R studies in dogs with melanistic mask or brindle patterns.	GP00000574	MC1R Q01726	Morphology	M264V	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies)		MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000576	MC1R Q01726	Morphology	R18C	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000577	MC1R Q01726	Morphology	R109W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000578	MC1R Q01726	Morphology	R160W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000579	MC1R Q01726	Morphology	Q233H	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Candidate Gene	Marklund L; Moller MJ; Sandberg K ; et al. (1996) A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated wit[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000580	MC1R Q01726	Morphology	S83F	Equus caballus horse - (species)	Equus caballus horse - (species)		MC1R	Equus caballus horse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus poschiavinus (species)	Interspecific	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000583	MC1R Q01726	Morphology	S69L	Mus musculus house mouse - (species)	Mus poschiavinus (species)		MC1R	Mus poschiavinus (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000584	MC1R Q01726	Morphology	E92K	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000585	MC1R Q01726	Morphology	L98P	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Wada A; Kunieda T; Nishimura M ; et al. (2005 Mar-Apr) A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred s[...]	GP00000586	MC1R Q01726	Morphology	W252C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Candidate Gene	Våge DI; Klungland H; Lu D ; et al. (1999) Molecular and pharmacological characterization of dominant black coat color in sheep. 1 Additional References Hepp D; Gonçalves GL; Moreira GR (2016) Epistatic Interaction of the Melanocortin 1 Receptor and Agouti Signaling Protein Genes Modulates Wo[...]	GP00000591	MC1R Q01726	Morphology	D121N	Ovis aries sheep - (species)	Ovis aries sheep - (species)		MC1R	Ovis aries sheep - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Candidate Gene	Våge DI; Klungland H; Lu D ; et al. (1999) Molecular and pharmacological characterization of dominant black coat color in sheep. 1 Additional References Hepp D; Gonçalves GL; Moreira GR (2016) Epistatic Interaction of the Melanocortin 1 Receptor and Agouti Signaling Protein Genes Modulates Wo[...]	GP00000592	MC1R Q01726	Morphology	M73K	Ovis aries sheep - (species)	Ovis aries sheep - (species)		MC1R	Ovis aries sheep - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Linkage Mapping	Hoekstra HE; Hirschmann RJ; Bundey RA ; et al. (2006) A single amino acid mutation contributes to adaptive beach mouse color pattern.	GP00000594	MC1R Q01726	Morphology	R65C	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		MC1R	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Rattus rattus black rat - (species)	Interspecific	Candidate Gene	Kambe Y; Tanikawa T; Matsumoto Y ; et al. (2011) Origin of agouti-melanistic polymorphism in Wild Black Rats (Rattus rattus) inferred from Mc1r gene [...]	GP00000595	MC1R Q01726	Morphology	Glu93Lys	Rattus tanezumi Oriental house rat - (species)	Rattus rattus black rat - (species)		MC1R	Rattus rattus black rat - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ursus americanus American black bear - (species)	Intraspecific	Candidate Gene	Ritland K; Newton C; Marshall HD (2001) Inheritance and population structure of the white-phased "Kermode" black bear.	GP00000597	MC1R Q01726	Morphology	Y298C	Ursus americanus American black bear - (species)	Ursus americanus American black bear - (species)		MC1R	Ursus americanus American black bear - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Vulpes vulpes red fox - (species)	Domesticated	Candidate Gene	Våge DI; Lu D; Klungland H ; et al. (1997) A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes.	GP00000598	MC1R Q01726	Morphology	C125R; constitutively active receptor	Vulpes vulpes red fox - (species)	Vulpes vulpes red fox - (species)		MC1R	Vulpes vulpes red fox - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Anser caerulescens snow goose - (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000599	MC1R Q01726	Morphology	V85M	Anser caerulescens snow goose - (species)	Anser caerulescens snow goose - (species)		MC1R	Anser caerulescens snow goose - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Coereba flaveola Bananaquit - (species) D	Intraspecific	Candidate Gene	Theron E; Hawkins K; Bermingham E ; et al. (2001) The molecular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor point mu[...]	GP00000600	MC1R Q01726	Morphology	E92K	Coereba flaveola Bananaquit - (species)	Coereba flaveola Bananaquit - (species) D		MC1R	Coereba flaveola Bananaquit - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Columba livia rock pigeon - (species)	Domesticated	Candidate Gene	Guernsey MW; Ritscher L; Miller MA ; et al. (2013) A Val85Met mutation in melanocortin-1 receptor is associated with reductions in eumelanic pigmentati[...]	GP00000601	MC1R Q01726	Morphology	Val85Met (G253A)	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species)		MC1R	Columba livia rock pigeon - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Nadeau NJ; Minvielle F; Mundy NI (2006) Association of a Glu92Lys substitution in MC1R with extended brown in Japanese quail (Coturnix japon[...]	GP00000602	MC1R Q01726	Morphology	E92K	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)		MC1R	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Falco rusticolus gyrfalcon - (species)	Intraspecific	Candidate Gene	Johnson JA; Ambers AD; Burnham KK (2012 May-Jun) Genetics of plumage color in the Gyrfalcon (Falco rusticolus): analysis of the melanocortin-1 recept[...]	GP00000604	MC1R Q01726	Morphology	Val128Ile	Falco rusticolus gyrfalcon - (species)	Falco rusticolus gyrfalcon - (species)		MC1R	Falco rusticolus gyrfalcon - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...] 1 Additional References Kerje S; Lind J; Schütz K (2003) Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken.	GP00000605	MC1R Q01726	Morphology	E92K; constitutive activation	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...]	GP00000606	MC1R Q01726	Morphology	C33W	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...]	GP00000607	MC1R Q01726	Morphology	D37G	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...]	GP00000608	MC1R Q01726	Morphology	L244P	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Kerje S; Lind J; Schütz K ; et al. (2003) Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken.	GP00000609	MC1R Q01726	Morphology	H215P	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Malurus leucopterus white-winged fairy-wren - (species)	Intraspecific	Candidate Gene	Doucet SM; Shawkey MD; Rathburn MK ; et al. (2004) Concordant evolution of plumage colour, feather microstructure and a melanocortin receptor gene betw[...]	GP00000610	MC1R Q01726	Morphology	A16T caused by guanine-to-adenine (G_A) transition at site 46; and/or I38N cause by a tyrosine-to-adenine (T_A) transition at site 113; and/or V11N caused by a G_A transition at site 331; and/or Q157R caused by an A_G substitution at site 470; Val166Ileu - exact causing amino acid change(s) unknown	Malurus leucopterus white-winged fairy-wren - (species)	Malurus leucopterus white-winged fairy-wren - (species)		MC1R	Malurus leucopterus white-winged fairy-wren - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Stercorarius parasiticus (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000611	MC1R Q01726	Morphology	R230H	Stercorarius parasiticus (species)	Stercorarius parasiticus (species)		MC1R	Stercorarius parasiticus (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula leucogaster (species)	Intraspecific	Candidate Gene	Baião PC; Parker PG (2012 May-Jun) Evolution of the melanocortin-1 receptor (MC1R) in Boobies and Gannets (Aves, Suliformes).	GP00000612	MC1R Q01726	Morphology	R112H	Sula leucogaster (species)	Sula leucogaster (species)		MC1R	Sula leucogaster (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula sula red-footed booby - (species)	Intraspecific	Candidate Gene	Baião PC; Schreiber E; Parker PG (2007 Jul-Aug) The genetic basis of the plumage polymorphism in red-footed boobies (Sula sula): a melanocortin-1 re[...]	GP00000613	MC1R Q01726	Morphology	V85M and/or H207R; current data cannot determine which one or if both these substitutions are underlying the phenotypic variation	Sula sula red-footed booby - (species)	Sula sula red-footed booby - (species)		MC1R	Sula sula red-footed booby - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Smith R; Healy E; Siddiqui S (1998) Melanocortin 1 receptor variants in an Irish population.	GP00000615	MC1R Q01726	Morphology	R151C	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000616	MC1R Q01726	Morphology	D294H	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000617	MC1R Q01726	Morphology	R160W	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Box NF; Wyeth JR; O'Gorman LE ; et al. (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. 3 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. Harding RM; Healy E; Ray AJ (2000) Evidence for variable selective pressures at MC1R. Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000618	MC1R Q01726	Morphology	Val60Leu	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000619	MC1R Q01726	Morphology	Asp84Glu	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000620	MC1R Q01726	Morphology	Val92Met	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000621	MC1R Q01726	Morphology	Arg142His	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000622	MC1R Q01726	Morphology	Arg151Cys	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000623	MC1R Q01726	Morphology	Ile155Thr	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000624	MC1R Q01726	Morphology	Arg160Trp	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000625	MC1R Q01726	Morphology	Arg163Gln	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000626	MC1R Q01726	Morphology	Asp294His	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Aspidoscelis inornatus Little striped whiptail - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000627	MC1R Q01726	Morphology	I170T	Aspidoscelis inornatus Little striped whiptail - (species)	Aspidoscelis inornatus Little striped whiptail - (species)		MC1R	Aspidoscelis inornatus Little striped whiptail - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Holbrookia maculata lesser earless lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000628	MC1R Q01726	Morphology	V168I; but failed functional validation in Rosenblum et al. 2010	Holbrookia maculata lesser earless lizard - (species)	Holbrookia maculata lesser earless lizard - (species)		MC1R	Holbrookia maculata lesser earless lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Sceloporus undulatus fence lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Römpler H; Schöneberg T ; et al. (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000629	MC1R Q01726	Morphology	H208Y	Sceloporus undulatus fence lizard - (species)	Sceloporus undulatus fence lizard - (species)		MC1R	Sceloporus undulatus fence lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Lalueza-Fox C; Römpler H; Caramelli D ; et al. (2007) A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals.	GP00000630	MC1R Q01726	Morphology	Arg307Gly	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000632	MC1R Q01726	Morphology	V"92"M actually at 95	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000633	MC1R Q01726	Morphology	D"121"N Actually 124	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000634	MC1R Q01726	Morphology	A"161"V actually 164	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000635	MC1R Q01726	Morphology	L"99" P Actually 102	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000636	MC1R Q01726	Morphology	A"240"T actually 243	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC4R	Feeding behavior	Coding, SNP	Astyanax mexicanus Mexican tetra - (species)	Intraspecific	Linkage Mapping	Aspiras AC; Rohner N; Martineau B ; et al. (2015) Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditio[...]	GP00000637	mc4r B0V1P1	Behavior	Gly145Ser (candidate mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species)		MC4R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MDS3	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000641	MDS3 P53094	Physiology	Phe - Val substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MDS3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Linkage Mapping	Drögemüller C; Philipp U; Haase B ; et al. (2007) A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal[...]	GP00000643	Mlph Q91V27	Morphology	GA substitution disrupting Splice Site	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Melanophilin (MLPH)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Gallus gallus chicken - (species) D	Domesticated	Candidate Gene	Vaez M; Follett SA; Bed'hom B ; et al. (2008) A single point-mutation within the melanophilin gene causes the lavender plumage colour dilution phe[...]	GP00000645	Mlph Q91V27	Morphology	Arg35Trp	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Melanophilin (MLPH)	Gallus gallus chicken - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Cirera S; Markakis MN; Christensen K ; et al. (2013) New insights into the melanophilin (MLPH) gene controlling coat color phenotypes in American mink.	GP00000647	Mlph Q91V27	Morphology	Splice donor site variation in exon 8 resulting in a premature stop codon	Neovison vison American mink - (species)	Neovison vison American mink - (species) D		Melanophilin (MLPH)	Neovison vison American mink - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Oryctolagus (genus) D	Domesticated	Candidate Gene	Lehner S; Gähle M; Dierks C ; et al. (2013) Two-exon skipping within MLPH is associated with coat color dilution in rabbits.	GP00000649	Mlph Q91V27	Morphology	c.111-5C>A (exon skipping resulting in frameshift and truncated protein)	Oryctolagus (genus)	Oryctolagus (genus) D		Melanophilin (MLPH)	Oryctolagus (genus)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Haase B; Blatter M ; et al. (2012) Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.	GP00000659	Mitf Q08874	Morphology	N310S yielding defective DNA-binding	Equus caballus horse - (species)	Equus caballus horse - (species) D		Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
MKT1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000662	MKT1 P40850	Physiology	D30G (reversion; functionally verified); evolved independently in 3 lines	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MKT1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MKT1	Temperature tolerance Virulence Sporulation efficiency Sporulation efficiency Xenobiotic resistance (alcohol; ethanol) Xenobiotic resistance (genotoxic DNA-damage agent)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 5 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus. Demogines A; Smith E; Kruglyak L (2008) Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. Swinnen S; Schaerlaekens K; Pais T (2012) Identification of novel causative genes determining the complex trait of high ethanol tolerance in y[...] Ehrenreich IM; Torabi N; Jia Y (2010) Dissection of genetically complex traits with extremely large pools of yeast segregants. Deutschbauer AM; Davis RW (2005) Quantitative trait loci mapped to single-nucleotide resolution in yeast.	GP00000666	MKT1 P40850	Physiology Physiology Physiology Physiology Physiology Physiology	G30D (functionally verified); or haplotype including G30D (functionally verified)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		MKT1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Mla1	Pathogen resistance	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Mahadevappa M; Descenzo RA; Wise RP (1994) Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...] 3 Additional References Wei F; Gobelman-Werner K; Morroll SM (1999) The Mla (powdery mildew) resistance cluster is associated with three NBS-LRR gene families and suppr[...] Halterman D; Zhou F; Wei F (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...] Jordan T; Seeholzer S; Schwizer S (2011) The wheat Mla homologue TmMla1 exhibits an evolutionarily conserved function against powdery mildew [...]	GP00000668	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain - exact amino acid change unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		Mla1	Hordeum vulgare (species)	Published - Accepted by Curator
Mla13	Pathogen resistance	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Mahadevappa M; Descenzo RA; Wise RP (1994) Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...] 2 Additional References Wei F; Gobelman-Werner K; Morroll SM (1999) The Mla (powdery mildew) resistance cluster is associated with three NBS-LRR gene families and suppr[...] Halterman D; Zhou F; Wei F (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...]	GP00000670	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain - exact amino acid change unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		Mla13	Hordeum vulgare (species)	Published - Accepted by Curator
Mla6	Pathogen resistance	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Mahadevappa M; Descenzo RA; Wise RP (1994) Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...] 2 Additional References Wei F; Gobelman-Werner K; Morroll SM (1999) The Mla (powdery mildew) resistance cluster is associated with three NBS-LRR gene families and suppr[...] Halterman D; Zhou F; Wei F (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...]	GP00000671	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain - exact amino acid change(s) unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		Mla6	Hordeum vulgare (species)	Published - Accepted by Curator
MLO1	Pathogen resistance	Coding, SNP N	Pisum sativum pea - (species)	Domesticated	Linkage Mapping	Pavan S; Schiavulli A; Appiano M ; et al. (2011) Pea powdery mildew er1 resistance is associated to loss-of-function mutations at a MLO homologous lo[...]	GP00000673	MLO P93766	Physiology	1bp substitution resulting in premature stop codon N	Pisum sativum pea - (species)	Pisum sativum pea - (species)		MLO1	Pisum sativum pea - (species)	Published - Accepted by Curator
MRS1	F2 lethality	3 Mutations: Coding SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000678	MRS1 P07266	Physiology	3 mutations	Saccharomyces paradoxus (species) Saccharomyces bayanus (species) Saccharomyces kudriavzevii (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MRS1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00000679	CUP1-1 P0CX80	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)	Glycogen content (muscles)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Milan D; Jeon JT; Looft C ; et al. (2000) A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle.	GP00000682	Prkag3 Q8BGM7	Physiology	R200Q in CBS1; which is the most conserved region among AMPK g chain isoforms; and R200 is conserved in mammalian and Drosophila AMPK g isoforms	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
Myosin heavy chain 9	Heat tolerance Racing performance	Cis-regulatory, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Huson HJ; vonHoldt BM; Rimbault M ; et al. (2012) Breed-specific ancestry studies and genome-wide association analysis highlight an association betwee[...]	GP00000684	MYH9 P35579	Physiology Physiology	Several candidate SNPs - exact causing mutation(s) unknown	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Myosin heavy chain 9	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000687	MSTN O14793	Morphology	Q204* caused by C610T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000688	MSTN O14793	Morphology	E226* caused by G676T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	McPherron AC; Lee SJ (1997) Double muscling in cattle due to mutations in the myostatin gene. 2 Additional References Grobet L; Poncelet D; Royo LJ (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...] Kambadur R; Sharma M; Smith TP (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.	GP00000689	MSTN O14793	Morphology	C313Y caused by G938A; disrupts disulphide bond	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Marchitelli C; Savarese MC; Crisà A ; et al. (2003) Double muscling in Marchigiana beef breed is caused by a stop codon in the third exon of myostatin g[...]	GP00000690	MSTN O14793	Morphology	E291* caused by G>T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Alexander LJ; Kuehn LA; Smith TP ; et al. (2009) A Limousin specific myostatin allele affects longissimus muscle area and fatty acid profiles in a Wa[...]	GP00000692	MSTN O14793	Morphology	Phe94Leu	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Cis-regulatory, SNP	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Clop A; Marcq F; Takeda H ; et al. (2006) A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects musc[...]	GP00000695	MSTN O14793	Morphology	1bp change; generates binding site for two muscle-expressed miRNAs; causing mRNA degradation and lower levels of circulating myostatin	Ovis aries sheep - (species)	Ovis aries sheep - (species)		Myostatin (MSTN = GDF8)	Ovis aries sheep - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Varanus salvator water monitor - (species) D Varanus niloticus (species) D Varanus albigularis cape monitor - (species) D	Interspecific	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000699	Atp1a1 Q8VDN2	Physiology	2 mutations	Varanus tristis (species) Varanus mitchelli (species) Varanus scalaris (species)	Varanus salvator water monitor - (species) D Varanus niloticus (species) D Varanus albigularis cape monitor - (species) D		Na/K-ATPase alpha-subunit	Varanus salvator water monitor - (species) Varanus niloticus (species) Varanus albigularis cape monitor - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Natricinae (subfamily) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000700	Atp1a1 Q8VDN2	Physiology	2 mutations	Colubridae colubrid snakes - (family)	Natricinae (subfamily) D		Na/K-ATPase alpha-subunit	Natricinae (subfamily)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Leptodactylus ocellatus argus frog - (species) D	Intraspecific	Candidate Gene	Moore DJ; Halliday DC; Rowell DM ; et al. (2009) Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000701	Atp1a1 Q8VDN2	Physiology	2 mutations	Leptodactylus ocellatus argus frog - (species)	Leptodactylus ocellatus argus frog - (species) D		Na/K-ATPase alpha-subunit	Leptodactylus ocellatus argus frog - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Atelopus spumarius Pebas stubfoot toad - (species) D Rhinella marina marine toad - (species) D Rhinella granulosa granular toad - (species) D	Intergeneric or Higher	Candidate Gene	Moore DJ; Halliday DC; Rowell DM ; et al. (2009) Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000702	Atp1a1 Q8VDN2	Physiology	2 mutations	Hyloidea (superfamily)	Atelopus spumarius Pebas stubfoot toad - (species) D Rhinella marina marine toad - (species) D Rhinella granulosa granular toad - (species) D		Na/K-ATPase alpha-subunit	Atelopus spumarius Pebas stubfoot toad - (species) Rhinella marina marine toad - (species) Rhinella granulosa granular toad - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Naja melanoleuca forest cobra - (species) D Naja naja Indian cobra - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000703	Atp1a1 Q8VDN2	Physiology	2 mutations	Ophiophagus hannah king cobra - (species) Pseudechis australis mulga snake - (species) Hemiaspis signata (species)	Naja melanoleuca forest cobra - (species) D Naja naja Indian cobra - (species) D		Na/K-ATPase alpha-subunit	Naja melanoleuca forest cobra - (species) Naja naja Indian cobra - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	4 Mutations: Coding SNP	Chrysochus auratus dogbane beetle - (species) D	Interspecific	Candidate Gene	Aardema ML; Zhen Y; Andolfatto P (2012) The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies. 1 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000704	Atp1a1 Q8VDN2	Physiology	4 mutations	Coleoptera beetles - (order)	Chrysochus auratus dogbane beetle - (species) D		Na/K-ATPase alpha-subunit	Chrysochus auratus dogbane beetle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Rhyssomatus lineaticollis (species) D	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community.	GP00000705	K+ ATPase alpha subunit R4ZHW8	Physiology	C104Y	Coleoptera beetles - (order)	Rhyssomatus lineaticollis (species) D		Na/K-ATPase alpha-subunit	Rhyssomatus lineaticollis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Tetraopes tetrophthalmus red milkweed beetle - (species) D	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000706	Atp1a1 Q8VDN2	Physiology	2 mutations	Coleoptera beetles - (order)	Tetraopes tetrophthalmus red milkweed beetle - (species) D		Na/K-ATPase alpha-subunit	Tetraopes tetrophthalmus red milkweed beetle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	3 Mutations: Coding SNP	Danaus plexippus monarch butterfly - (species) D	Interspecific	Candidate Gene	Aardema ML; Zhen Y; Andolfatto P (2012) The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies. 1 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000707	Atp1a1 Q8VDN2	Physiology	3 mutations	Nymphalidae brushfoots - (family)	Danaus plexippus monarch butterfly - (species) D		Na/K-ATPase alpha-subunit	Danaus plexippus monarch butterfly - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Erinaceus europaeus western European hedgehog - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000708	Atp1a1 Q8VDN2	Physiology	2 mutations	Condylura cristata star-nosed mole - (species)	Erinaceus europaeus western European hedgehog - (species) D		Na/K-ATPase alpha-subunit	Erinaceus europaeus western European hedgehog - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	4 Mutations: Coding SNP	Oncopeltus fasciatus milkweed bug - (species) D Lygaeus kalmii (species) D	Intergeneric or Higher	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] 2 Additional References Zhen Y; Aardema ML; Medina EM (2012) Parallel molecular evolution in an herbivore community. Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000709	Atp1a1 Q8VDN2	Physiology	4 mutations	Insecta true insects - (class)	Oncopeltus fasciatus milkweed bug - (species) D Lygaeus kalmii (species) D		Na/K-ATPase alpha-subunit	Oncopeltus fasciatus milkweed bug - (species) Lygaeus kalmii (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Labidomera clivicollis (species) D	Intergeneric or Higher	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] 1 Additional References Zhen Y; Aardema ML; Medina EM (2012) Parallel molecular evolution in an herbivore community.	GP00000710	Atp1a1 Q8VDN2	Physiology	2 mutations	Insecta true insects - (class)	Labidomera clivicollis (species) D		Na/K-ATPase alpha-subunit	Labidomera clivicollis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Liriomyza asclepiadis (species) D	Interspecific	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000711	Atp1a1 Q8VDN2	Physiology	N122H	Insecta true insects - (class)	Liriomyza asclepiadis (species) D		Na/K-ATPase alpha-subunit	Liriomyza asclepiadis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Aphis nerii oleander aphid - (species)	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community.	GP00000712	K+ ATPase alpha subunit R4ZHW8	Physiology	2 mutations	Insecta true insects - (class)	Aphis nerii oleander aphid - (species)		Na/K-ATPase alpha-subunit	Aphis nerii oleander aphid - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000713	Atp1a1 Q8VDN2	Physiology	Q111L	Lepidoptera butterflies and moths - (order)	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)		Na/K-ATPase alpha-subunit	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Murinae (subfamily) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000714	Atp1a1 Q8VDN2	Physiology	2 mutations	Rodentia rodent - (order)	Murinae (subfamily) D		Na/K-ATPase alpha-subunit	Murinae (subfamily)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Varanus varius lace monitor - (species) D Varanus tristis (species) D Varanus scalaris (species) D	Interspecific	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000715	Atp1a1 Q8VDN2	Physiology	2 mutations	Varanus salvator water monitor - (species) Varanus rudicollis roughneck monitor - (species) Varanus dumerilii Dumeril monitor - (species)	Varanus varius lace monitor - (species) D Varanus tristis (species) D Varanus scalaris (species) D		Na/K-ATPase alpha-subunit	Varanus varius lace monitor - (species) Varanus tristis (species) Varanus scalaris (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Bitis arietans puff adder - (species) D Bitis nasicornis rhinoceros viper - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000716	Atp1a1 Q8VDN2	Physiology	2 mutations	Vipera berus adder - (species)	Bitis arietans puff adder - (species) D Bitis nasicornis rhinoceros viper - (species) D		Na/K-ATPase alpha-subunit	Bitis arietans puff adder - (species) Bitis nasicornis rhinoceros viper - (species)	Published - Accepted by Curator
nath-10	Fertility (sperm number; egg laying rate)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Duveau F; Félix MA (2012) Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.	GP00000718	nath-10 O01757	Morphology	Met746Ile (according to Table S2 C>T but it should be G>A - Needs curation)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		nath-10	Caenorhabditis elegans (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Mya arenaria (species) D	Intraspecific	Candidate Gene	Bricelj VM; Connell L; Konoki K ; et al. (2005) Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.	GP00000721	SCN4A P35499	Physiology	E945D	Mya arenaria (species)	Mya arenaria (species) D		SCN4A (Nav1.4)	Mya arenaria (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000722	SCN4A P35499	Physiology	Y401N	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)		SCN4A (Nav1.4a gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000723	SCN4A P35499	Physiology	Y401C	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)		SCN4A (Nav1.4a gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000724	SCN4A P35499	Physiology	G1569D in DIV domain and D1568S in DIV domain with D1568S supposed to increase the resistance - exact causing mutation(s) unknown	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D		SCN4A (Nav1.4)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Rhabdophis tigrinus Tiger keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000725	SCN4A P35499	Physiology	I1555M	Thamnophis elegans Western terrestrial garter snake - (species)	Rhabdophis tigrinus Tiger keelback - (species) D		SCN4A (Nav1.4)	Rhabdophis tigrinus Tiger keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000726	SCN4A P35499	Physiology	D1277E in DIII domain	Thamnophis couchii (species)	Thamnophis atratus (species) D		SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000727	SCN4A P35499	Physiology	D1568N in DIV domain	Thamnophis couchii (species)	Thamnophis atratus (species) D		SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis couchii (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000728	SCN4A P35499	Physiology	M1276T in DIII domain	Thamnophis atratus (species)	Thamnophis couchii (species) D		SCN4A (Nav1.4)	Thamnophis couchii (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Hebius pryeri Pryer's keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000729	SCN4A P35499	Physiology	D1227E = D945E in DIII domain	Hebius vibakari Japanese keelback - (species)	Hebius pryeri Pryer's keelback - (species) D		SCN4A (Nav1.4)	Hebius pryeri Pryer's keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000730	SCN4A P35499	Physiology	G1566A in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000731	SCN4A P35499	Physiology	I1561V in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000732	SCN4A P35499	Physiology	I1556L and/or D1568N and/or G1569V	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes. 1 Additional References Jost MC; Hillis DM; Lu Y (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000733	SCN4A P35499	Physiology	E945D	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)		SCN4A (Nav1.4b gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Jost MC; Hillis DM; Lu Y ; et al. (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000734	SCN4A P35499	Physiology	M1240T	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)		SCN4A (Nav1.4b gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
Nav1.6 sodium channel	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000735	SCN8A Q9UQD0	Physiology	Ile1709Val	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D		Nav1.6 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
Nav1.7 sodium channel	Xenobiotic resistance (TTX)	4 Mutations: Coding SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000736	SCN9A Q15858	Physiology	4 mutations	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D		Nav1.7 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
Neverland	Ecological specialization Cholesterol metabolism	4 Mutations: Coding SNP	Drosophila pachea (species) D	Interspecific	Candidate Gene	Lang M; Murat S; Clark AG ; et al. (2012) Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.	GP00000738	nvd Q1JUZ1	Physiology Physiology	4 mutations	Drosophila acanthoptera (species)	Drosophila pachea (species) D	Courtier Virginie	Neverland	Drosophila pachea (species)	Published - Accepted by Curator	would be good to add text	March 8, 2019 10:00
npr-1	Aggregation behavior Foraging behavior CO2 avoidance Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	de Bono M; Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in[...] 4 Additional References Gloria-Soria A; Azevedo RB (2008) npr-1 Regulates foraging and dispersal strategies in Caenorhabditis elegans. Andersen EC; Bloom JS; Gerke JP (2014) A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth[...] McGrath PT; Rockman MV; Zimmer M (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] Reddy KC; Andersen EC; Kruglyak L (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans.	GP00000739	npr-1 Q18534	Behavior Behavior Behavior Behavior	Val215Phe (pleiotropic; see other entries)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		npr-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Nramp aluminum transporter1	Metal tolerance	2 Mutations: Coding SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Famoso AN; Zhao K; Clark RT ; et al. (2011) Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide ass[...]	GP00000740	NRAT1 Q6ZG85	Physiology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Nramp aluminum transporter1	Oryza sativa rice - (species)	Published - Accepted by Curator
Oca2	Coloration (eyes; skin)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Eiberg H; Troelsen J; Nielsen M ; et al. (2008) Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory el[...] 3 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...] Visser M; Kayser M; Palstra RJ (2012) HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long[...] Beleza S; Johnson NA; Candille SI (2013) Genetic architecture of skin and eye color in an African-European admixed population.	GP00000747	Oca2 Q62052	Morphology	Causative SNP in enhancer localized in intron of neighbor gene	Homo sapiens human - (species)	Homo sapiens human - (species)		Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
Oca2	Coloration (skin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Edwards M; Bigham A; Tan J ; et al. (2010) Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: furth[...] 1 Additional References Yang Z; Zhong H; Chen J (2016) A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution.	GP00000748	Oca2 Q62052	Morphology	His615Arg	Homo sapiens human - (species)	Homo sapiens human - (species) D		Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
Odorant receptor 3 (OR3)	Olfactory behavior (pheromone)	Coding, SNP	Ostrinia furnacalis Asian corn borer - (species)	Interspecific	Candidate Gene	Leary GP; Allen JE; Bunger PL ; et al. (2012) Single mutation to a sex pheromone receptor provides adaptive specificity between closely related mo[...]	GP00000749	OR3 D3J5H6	Behavior	A148T	Ostrinia nubilalis European corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species)		Odorant receptor 3 (OR3)	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]	Fragrance	Cis-regulatory, SNP	Petunia x hybrida (species)	Domesticated	Linkage Mapping	Van Moerkercke A; Haring MA; Schuurink RC (2011) The transcription factor EMISSION OF BENZENOIDS II activates the MYB ODORANT1 promoter at a MYB bind[...]	GP00000751	ODO1 Q50EX6	Physiology	C/T substitution in enhancer region MYB-TF binding site	Petunia x hybrida (species)	Petunia x hybrida (species)		ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]	Petunia x hybrida (species)	Published - Accepted by Curator
opsin	Color vision (blue)	Coding, SNP	Alloteuthis subulata (species)	Interspecific	Candidate Gene	Morris A; Bowmaker JK; Hunt DM (1993) The molecular basis of a spectral shift in the rhodopsins of two species of squid from different pho[...]	GP00000755	opn1sw1 Q9W6A9	Physiology	F270S	Loligo forbesii northern European squid - (species)	Alloteuthis subulata (species)		opsin	Alloteuthis subulata (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision	Coding, SNP	Odontoceti tooth whales - (suborder)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000757	OPN1SW P03999	Physiology	E113G; disrupts opsin-chromophore binding	Cetacea whales - (order)	Odontoceti tooth whales - (suborder)		opsin - (SWS1)	Odontoceti tooth whales - (suborder)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	2 Mutations: Coding SNP	Melopsittacus undulatus budgerigar - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Radlwimmer FB; Blow NS (2000) Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change. 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000760	OPN1SW P03999	Physiology	2 mutations	Aves birds - (class)	Melopsittacus undulatus budgerigar - (species) D		opsin - (SWS1)	Melopsittacus undulatus budgerigar - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	2 Mutations: Coding SNP	Rhea americana greater rhea - (species) D	Intergeneric or Higher	Candidate Gene	Odeen A; Hastad O (2003) Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...] 2 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments. Wright MW; Bowmaker JK (2001) Retinal photoreceptors of paleognathous birds: the ostrich (Struthio camelus) and rhea (Rhea america[...]	GP00000761	OPN1SW P03999	Physiology	2 mutations	Aves birds - (class)	Rhea americana greater rhea - (species) D		opsin - (SWS1)	Rhea americana greater rhea - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	2 Mutations: Coding SNP	Larus (genus) D	Intergeneric or Higher	Candidate Gene	Odeen A; Hastad O (2003) Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...] 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000762	OPN1SW P03999	Physiology	2 mutations	Aves birds - (class)	Larus (genus) D		opsin - (SWS1)	Larus (genus)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	Coding, SNP	Trogon curucui (species) D	Intergeneric or Higher	Candidate Gene	Odeen A; Hastad O (2003) Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...] 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000763	OPN1SW P03999	Physiology	S86F	Aves birds - (class)	Trogon curucui (species) D		opsin - (SWS1)	Trogon curucui (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	Coding, SNP	Taeniopygia guttata zebra finch - (species)	Intergeneric or Higher	Candidate Gene	Yokoyama S; Radlwimmer FB; Blow NS (2000) Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change. 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000764	OPN1SW P03999	Physiology	S90C	Passeriformes (order)	Taeniopygia guttata zebra finch - (species)		opsin - (SWS1)	Taeniopygia guttata zebra finch - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	3 Mutations: Coding SNP	Xenopus laevis African clawed frog - (species) D	Intergeneric or Higher	Candidate Gene	Takahashi Y; Yokoyama S (2005) Genetic basis of spectral tuning in the violet-sensitive visual pigment of African clawed frog, Xeno[...]	GP00000765	OPN1SW P03999	Physiology	3 mutations	Amniota amniotes - (no rank)	Xenopus laevis African clawed frog - (species) D		opsin - (SWS1)	Xenopus laevis African clawed frog - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, SNP	Macropodidae (family)	Intergeneric or Higher	Candidate Gene	Deeb SS; Wakefield MJ; Tada T ; et al. (2003) The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence[...] 1 Additional References Arrese CA; Oddy AY; Runham PB (2005) Cone topography and spectral sensitivity in two potentially trichromatic marsupials, the quokka (Set[...]	GP00000766	OPN1SW P03999	Physiology	F86Y	Metatheria marsupials - (no rank)	Macropodidae (family)		opsin - (SWS1)	Macropodidae (family)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, SNP	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Candidate Gene	Parry JW; Poopalasundaram S; Bowmaker JK ; et al. (2004) A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visu[...]	GP00000767	OPN1SW P03999	Physiology	F86V	Rodentia rodent - (order)	Cavia porcellus domestic guinea pig - (species)		opsin - (SWS1)	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, SNP	Sciurus carolinensis gray squirrel - (species)	Intergeneric or Higher	Candidate Gene	Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006) Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.	GP00000768	OPN1SW P03999	Physiology	F86Y	Rodentia rodent - (order)	Sciurus carolinensis gray squirrel - (species)		opsin - (SWS1)	Sciurus carolinensis gray squirrel - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWRh)	Color vision (blue shift)	2 Mutations: Coding SNP	Limenitis archippus viceroy - (species)	Intergeneric or Higher	Candidate Gene	Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007) Adaptive evolution of color vision as seen through the eyes of butterflies.	GP00000769	LWRh E2DZP1	Physiology	2 mutations	Limenitis arthemis white admiral - (species)	Limenitis archippus viceroy - (species)		opsin - rhodopsin (LWRh)	Limenitis archippus viceroy - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWRh)	Color vision (blue shift)	2 Mutations: Coding SNP	Junonia buckeyes - (genus)	Intergeneric or Higher	Candidate Gene	Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007) Adaptive evolution of color vision as seen through the eyes of butterflies.	GP00000770	LWRh E2DZP1	Physiology	2 mutations	Nymphalidae brushfoots - (family)	Junonia buckeyes - (genus)		opsin - rhodopsin (LWRh)	Junonia buckeyes - (genus)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, SNP	Balaenidae right whales - (family)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000775	OPN1LW P04000	Physiology	AG to GG splice site mutation	Cetacea whales - (order)	Balaenidae right whales - (family)		opsin - rhodopsin (LWS)	Balaenidae right whales - (family)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	Coding, SNP	Neochromis greenwoodi (species)	Interspecific	Candidate Gene	Terai Y; Seehausen O; Sasaki T ; et al. (2006) Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids.	GP00000776	OPN1LW P04000	Physiology	Candidate mutations are CS180A and/or I277C (human LWS/MWS numbering)	African cichlids (no rank)	Neochromis greenwoodi (species)		opsin - rhodopsin (LWS)	Neochromis greenwoodi (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	3 Mutations: Coding SNP	Pundamilia pundamilia (species)	Intraspecific	Candidate Gene	Seehausen O; Terai Y; Magalhaes IS ; et al. (2008) Speciation through sensory drive in cichlid fish.	GP00000777	OPN1LW P04000	Physiology	3 mutations	Pundamilia pundamilia (species)	Pundamilia pundamilia (species)		opsin - rhodopsin (LWS)	Pundamilia pundamilia (species)	Published - Accepted by Curator
opsin - rhodopsin (MWS=duplicate of LWS)	Color vision (green-shift)	7 Mutations: Coding SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Asenjo AB; Rim J; Oprian DD (1994) Molecular determinants of human red/green color discrimination. 1 Additional References Hunt DM; Dulai KS; Cowing JA (1998) Molecular evolution of trichromacy in primates.	GP00000778	OPN1MW P04001	Physiology	7 mutations	Primates (order)	Catarrhini (parvorder)		opsin - rhodopsin (MWS=duplicate of LWS)	Catarrhini (parvorder)	Published - Accepted by Curator
opsin - rhodopsin (UVRh2)	Color vision (UV-shift)	2 Mutations: Coding SNP	Heliconius pachinus (species) Heliconius erato crimson-patched longwing - (species) Heliconius hortense (species) Heliconius sapho (species) Heliconius charithonia zebra longwing - (species) Heliconius melpomene postman butterfly - (species) Heliconius elevatus (species) Heliconius cydno (species)	Intergeneric or Higher	Candidate Gene	Briscoe AD; Bybee SM; Bernard GD ; et al. (2010) Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution[...] 1 Additional References Yuan F; Bernard GD; Le J (2010) Contrasting modes of evolution of the visual pigments in Heliconius butterflies.	GP00000779	UVRh2 E2DZL8	Physiology	2 mutations	Nymphalidae brushfoots - (family)	Heliconius pachinus (species) Heliconius erato crimson-patched longwing - (species) Heliconius hortense (species) Heliconius sapho (species) Heliconius charithonia zebra longwing - (species) Heliconius melpomene postman butterfly - (species) Heliconius elevatus (species) Heliconius cydno (species)		opsin - rhodopsin (UVRh2)	Heliconius pachinus (species) Heliconius erato crimson-patched longwing - (species) Heliconius hortense (species) Heliconius sapho (species) Heliconius charithonia zebra longwing - (species) Heliconius melpomene postman butterfly - (species) Heliconius elevatus (species) Heliconius cydno (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	2 Mutations: Coding SNP	undetermined Cottoidei 'Lake Baikal' (species)	Intergeneric or Higher	Candidate Gene	Hunt DM; Fitzgibbon J; Slobodyanyuk SJ ; et al. (1996) Spectral tuning and molecular evolution of rod visual pigments in the species flock of cottoid fish [...]	GP00000780	RHO P08100	Physiology	2 mutations	undetermined Cottoidei 'Lake Baikal' (species)	undetermined Cottoidei 'Lake Baikal' (species)		opsin - rhodopsin1 (RH1)	undetermined Cottoidei 'Lake Baikal' (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	Coding, SNP	Megaderma lyra Indian false vampire - (species) D	Intergeneric or Higher	Candidate Gene	Sugawara T; Imai H; Nikaido M ; et al. (2010) Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.	GP00000781	RHO P08100	Physiology	D83N	Chiroptera bats - (order)	Megaderma lyra Indian false vampire - (species) D		opsin - rhodopsin1 (RH1)	Megaderma lyra Indian false vampire - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	2 Mutations: Coding SNP	Sebastolobus altivelis (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T; Yamato T (2007 Mar-Apr) Modulation of the absorption maximum of rhodopsin by amino acids in the C-terminus. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000782	RHO P08100	Physiology	2 mutations	Teleostei teleost fishes - (infraclass)	Sebastolobus altivelis (species) D		opsin - rhodopsin1 (RH1)	Sebastolobus altivelis (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	Coding, SNP	Flaveria trinervia (species)	Intergeneric or Higher	Candidate Gene	Sugawara T; Imai H; Nikaido M ; et al. (2010) Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.	GP00000783	RHO P08100	Physiology	D83N	Vespertilionidae common bats - (family)	Flaveria trinervia (species)		opsin - rhodopsin1 (RH1)	Flaveria trinervia (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	Squamata squamates - (order) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Zhang H; Radlwimmer FB ; et al. (1999) Adaptive evolution of color vision of the Comoran coelacanth (Latimeria chalumnae). 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000784	RHO P08100	Physiology	D83N	Amniota amniotes - (no rank)	Squamata squamates - (order) D		opsin - rhodopsin1 (RH1)	Squamata squamates - (order)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	2 Mutations: Coding SNP	Orcinus orca killer whale - (species) D	Intergeneric or Higher	Candidate Gene	Dungan SZ; Kosyakov A; Chang BS (2016) Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functi[...] 1 Additional References Meredith RW; Gatesy J; Emerling CA (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000785	RHO P08100	Physiology	2 mutations	Bos taurus cattle - (species)	Orcinus orca killer whale - (species) D		opsin - rhodopsin1 (RH1)	Orcinus orca killer whale - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	African cichlids (no rank)	Intergeneric or Higher	Candidate Gene	Sugawara T; Terai Y; Imai H ; et al. (2005) Parallelism of amino acid changes at the RH1 affecting spectral sensitivity among deep-water cichlid[...] 1 Additional References Nagai H; Terai Y; Sugawara T (2011) Reverse evolution in RH1 for adaptation of cichlids to water depth in Lake Tanganyika.	GP00000786	RHO P08100	Physiology	A292S and reversals; many independent cases	African cichlids (no rank)	African cichlids (no rank)		opsin - rhodopsin1 (RH1)	African cichlids (no rank)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	3 Mutations: Coding SNP	Tursiops truncatus bottlenose dolphin - (species)	Intergeneric or Higher	Candidate Gene	Fasick JI; Robsinson PR (1998) Mechanism of spectral tuning in the dolphin visual pigments. 2 Additional References Sugawara T; Imai H; Nikaido M (2010) Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation. Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000787	RHO P08100	Physiology	3 mutations	Mammalia mammals - (class)	Tursiops truncatus bottlenose dolphin - (species)		opsin - rhodopsin1 (RH1)	Tursiops truncatus bottlenose dolphin - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	Elephantidae elephants - (family)	Intergeneric or Higher	Candidate Gene	Yokoyama S; Takenaka N; Agnew DW ; et al. (2005) Elephants and human color-blind deuteranopes have identical sets of visual pigments. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000788	RHO P08100	Physiology	D83N	Mammalia mammals - (class)	Elephantidae elephants - (family)		opsin - rhodopsin1 (RH1)	Elephantidae elephants - (family)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	Physeteridae sperm whales - (family)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000789	RHO P08100	Physiology	K195T	Cetacea whales - (order)	Physeteridae sperm whales - (family)		opsin - rhodopsin1 (RH1)	Physeteridae sperm whales - (family)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	2 Mutations: Coding SNP	Latimeria menadoensis Menado coelacanth - (species) D Latimeria chalumnae coelacanth - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T (2000) Adaptive evolution of the African and Indonesian coelacanths to deep-sea environments.	GP00000790	RHO P08100	Physiology	2 mutations	Teleostei teleost fishes - (infraclass)	Latimeria menadoensis Menado coelacanth - (species) D Latimeria chalumnae coelacanth - (species) D		opsin - rhodopsin1 (RH1)	Latimeria menadoensis Menado coelacanth - (species) Latimeria chalumnae coelacanth - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	2 Mutations: Coding SNP	Cetacea whales - (order)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000791	RHO P08100	Physiology	2 mutations	Mammalia mammals - (class)	Cetacea whales - (order)		opsin - rhodopsin1 (RH1)	Cetacea whales - (order)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (red-shift)	Coding, SNP	Aristostomias scintillans shiny loosejaw - (species)	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T; Zhang H ; et al. (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...] 1 Additional References Yokoyama S (2012) Synthesis of Experimental Molecular Biology and Evolutionary Biology: An Example from the World of V[...]	GP00000792	RHO P08100	Physiology	D83N; M183F; M253L; F261Y; T289G; S292I; M317I - all together shift to red (see table S4 of Yokoyama PNAS) - individual changes not tested	Stomiidae barbeled dragonfishes - (family)	Aristostomias scintillans shiny loosejaw - (species)		opsin - rhodopsin1 (RH1)	Aristostomias scintillans shiny loosejaw - (species)	Published - Accepted by Curator
opsin - rhodopsin1-A (RH1-A)	Color vision (blue shift)	3 Mutations: Coding SNP	Conger myriaster whitespotted conger - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Takenaka N; Agnew DW ; et al. (2005) Elephants and human color-blind deuteranopes have identical sets of visual pigments. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000793	RHO P08100	Physiology	3 mutations	Anguilla japonica Japanese eel - (species)	Conger myriaster whitespotted conger - (species) D		opsin - rhodopsin1-A (RH1-A)	Conger myriaster whitespotted conger - (species)	Published - Accepted by Curator
opsin - rhodopsin1-B (RH1-B)	Color vision (blue shift)	Coding, SNP	Anguilla japonica Japanese eel - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Takenaka N; Agnew DW ; et al. (2005) Elephants and human color-blind deuteranopes have identical sets of visual pigments. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000794	RHO P08100	Physiology	D83N	Conger myriaster whitespotted conger - (species)	Anguilla japonica Japanese eel - (species) D		opsin - rhodopsin1-B (RH1-B)	Anguilla japonica Japanese eel - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000799	OR7D4 Q8NG98	Physiology	P79L	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000800	OR7D4 Q8NG98	Physiology	R227G	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000801	OR7D4 Q8NG98	Physiology	T133M	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000802	OR7D4 Q8NG98	Physiology	S84N	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000803	OR7D4 Q8NG98	Physiology	R227G	Homininae (subfamily)	Homo sapiens human - (species) D		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000804	OR7D4 Q8NG98	Physiology	M273T	Homininae (subfamily)	Homo sapiens human - (species) D		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OsPPKL1/qGL3	Grain size	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Zhang X; Wang J; Huang J ; et al. (2012) Rare allele of OsPPKL1 associated with grain length causes extra-large grain and a significant yield[...]	GP00000812	qLTG-3-1 B3IWI0	Morphology	Asp364Glu	Oryza sativa rice - (species)	Oryza sativa rice - (species)		OsPPKL1/qGL3	Oryza sativa rice - (species)	Published - Accepted by Curator
OsSPL14 / WFP	Grain yield	Cis-regulatory, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Jiao Y; Wang Y; Xue D ; et al. (2010) Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. 1 Additional References Miura K; Ikeda M; Matsubara A (2010) OsSPL14 promotes panicle branching and higher grain productivity in rice.	GP00000813	IPA1 D8WJ58	Morphology	Point mutation resulting in altered binding of a micro-RNA	Oryza sativa rice - (species)	Oryza sativa rice - (species)		OsSPL14 / WFP	Oryza sativa rice - (species)	Published - Accepted by Curator
OVATE	Fruit shape	Coding, SNP N	Solanum lycopersicum tomato - (species)	Domesticated	Linkage Mapping	Liu J; Van Eck J; Cong B ; et al. (2002) A new class of regulatory genes underlying the cause of pear-shaped tomato fruit.	GP00000815	Q8GSM4	Morphology	V164* caused by G>T; which leads to a 75-aa truncation in the C terminus of the predicted protein N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species)		OVATE	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Overdrive	Hybrid incompatibility (male F1 sterility)	Coding, SNP	Drosophila pseudoobscura (species)	Intraspecific	Linkage Mapping	Phadnis N; Orr HA (2009) A single gene causes both male sterility and segregation distortion in Drosophila hybrids.	GP00000816	Ovd Q2LZF7	Physiology	6 candidate non-synonymous changes - the effect of single amino acid changes has not been tested	Drosophila pseudoobscura (species)	Drosophila pseudoobscura (species)		Overdrive	Drosophila pseudoobscura (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	2 mutations	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 1 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Franck P; Siegwart M; Olivares J ; et al. (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D		para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Linkage Mapping	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Linkage Mapping	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 2 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] Park Y; Taylor MF (1997) A novel mutation L1029H in sodium channel gene hscp associated with pyrethroid resistance for Heliot[...]	GP00000833	para P35500	Physiology	L1029H (=position L1014)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]	GP00000839	para P35500	Physiology	L925I	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000840	para P35500	Physiology	M918L	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.	GP00000841	para P35500	Physiology	L1014H	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Vais H; Williamson MS; Devonshire AL ; et al. (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. 1 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000846	para P35500	Physiology	T929I (ACC to ATC or ATA)	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D		para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D		para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000848	para P35500	Physiology	L1014F	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)		para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
Period (per)	Courtship song	Coding, SNP	Drosophila simulans (species)	Interspecific	Linkage Mapping	Wheeler DA; Kyriacou CP; Greenacre ML ; et al. (1991) Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaste[...] 3 Additional References Kyriacou CP; Hall JC (1986) Interspecific genetic control of courtship song production and reception in Drosophila. Kyriacou CP; Green EW; Piffer A (2017) Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detec[...] Stern DL (2014) Reported Drosophila courtship song rhythms are artifacts of data analysis.	GP00000860	per P07663	Behavior	A121T and/or K125R and/or E165D and /or V224A	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Period (per)	Drosophila simulans (species)	Published - Accepted by Curator
PH4/GmMYB-G20-1	Coloration (flowers)	Coding, SNP N	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Takahashi R; Benitez ER; Oyoo ME ; et al. (2011 Jul-Aug) Nonsense mutation of an MYB transcription factor is associated with purple-blue flower color in soyb[...]	GP00000862	PH4 Q2TCH0	Morphology	Substitution creating premature Stop (codon 158) N	Glycine max soybean - (species)	Glycine max soybean - (species)		PH4/GmMYB-G20-1	Glycine max soybean - (species)	Published - Accepted by Curator
PHO84	Xenobiotic resistance	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Perlstein EO; Ruderfer DM; Roberts DC ; et al. (2007) Genetic basis of individual differences in the response to small-molecule drugs in yeast.	GP00000865	PHO84 P25297	Physiology	L259P	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		PHO84	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	Coding, SNP	Alloteropsis (genus)	Interspecific	Candidate Gene	Christin PA; Edwards EJ; Besnard G ; et al. (2012) Adaptive evolution of C(4) photosynthesis through recurrent lateral gene transfer.	GP00000866	PPCA P30694	Physiology	Haplotype of several candidate a.a. ; lateral gene transfer between convergent C4 species	Alloteropsis (genus)	Alloteropsis (genus)		phosphoenolpyruvate carboxylase (PEPC)	Alloteropsis (genus)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	2 Mutations: Coding SNP N	Flaveria trinervia (species)	Interspecific	Candidate Gene	Bläsing OE; Westhoff P; Svensson P (2000) Evolution of C4 phosphoenolpyruvate carboxylase in Flaveria, a conserved serine residue in the carbo[...] 1 Additional References Engelmann S; Bläsing OE; Gowik U (2003) Molecular evolution of C4 phosphoenolpyruvate carboxylase in the genus Flaveria--a gradual increase [...]	GP00000867	PPCA P30694	Physiology	2 mutations	Flaveria pringlei (species)	Flaveria trinervia (species)		phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	Cis-regulatory, SNP	Flaveria trinervia (species)	Interspecific	Candidate Gene	Akyildiz M; Gowik U; Engelmann S ; et al. (2007) Evolution and function of a cis-regulatory module for mesophyll-specific gene expression in the C4 d[...]	GP00000869	PPCA P30694	Physiology	G->A	Flaveria pringlei (species)	Flaveria trinervia (species)		phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
phytochrome A (PHYA)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Maloof JN; Borevitz JO; Dabi T ; et al. (2001) Natural variation in light sensitivity of Arabidopsis.	GP00000870	PHYA P14712	Physiology	M548T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome A (PHYA)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome B (PHYB)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Filiault DL; Wessinger CA; Dinneny JR ; et al. (2008) Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.	GP00000871	PHYB P14713	Physiology	I143L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome B (PHYB)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome C (PHYC)	Light sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006) The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]	GP00000873	PHYC P14714	Physiology	K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome C (PHYC)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Pi-ta	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Bryan GT; Wu KS; Farrall L ; et al. (2000) tA single amino acid difference distinguishes resistant and susceptible alleles of the rice blast re[...] 2 Additional References He Z; Zhai W; Wen H (2011) Two evolutionary histories in the genome of rice: the roles of domestication genes. Xu X; Liu X; Ge S (2011) Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically [...]	GP00000876	Pi-ta C9E6G5	Physiology	Ala918Ser	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi-ta	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi2 (Nbs4-Pi2)	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Zhou B; Qu S; Liu G ; et al. (2006) The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance [...]	GP00000877	PI2 M1EC06	Physiology	eight amino acid changes - exact causing change(s) unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi2 (Nbs4-Pi2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi36	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Liu X; Lin F; Wang L ; et al. (2007) The in silico map-based cloning of Pi36, a rice coiled-coil nucleotide-binding site leucine-rich rep[...]	GP00000878	Pi36 D5J6W0	Physiology	Asp590Ser	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi36	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi37	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Lin F; Chen S; Que Z ; et al. (2007) The blast resistance gene Pi37 encodes a nucleotide binding site leucine-rich repeat protein and is [...]	GP00000879	Pi37 Q06AJ9	Physiology	V239A and I247M are the only amino acid substitutions found in all tested resistant strains- the effect of each individual amino acid change has not been tested	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi37	Oryza sativa rice - (species)	Published - Accepted by Curator
Piz-t	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Zhou B; Qu S; Liu G ; et al. (2006) The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance [...]	GP00000895	Piz-t Q0H213	Physiology	Coding variation in the LRR domain	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Piz-t	Oryza sativa rice - (species)	Published - Accepted by Curator
plep-1	Male-male copulatory behavior	Coding, SNP	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Noble LM; Chang AS; McNelis D ; et al. (2015) Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.	GP00000897	plep-1 A0A0K3AR66	Behavior	V278D	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		plep-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Pm3	Pathogen resistance	Coding, SNP	Triticum aestivum bread wheat - (species)	Intraspecific	Linkage Mapping	Yahiaoui N; Kaur N; Keller B (2009) Independent evolution of functional Pm3 resistance genes in wild tetraploid wheat and domesticated b[...] 1 Additional References Yahiaoui N; Brunner S; Keller B (2006) Rapid generation of new powdery mildew resistance genes after wheat domestication.	GP00000899	PM3 C1K3M2	Physiology	Various substitution haplotypes - exact causing amino acid change(s) unknown - in hexaploid bread wheat one amino acid change in a solvent‐exposed residue of LRR27 (E1334 to V1334) was sufficient to convert the susceptible Pm3CS into a functional resistance allele (Yahiaoui et al., 2006).	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Pm3	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 2 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...] Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000900	PMA1 P05030	Physiology	Leu363Trp	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 2 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...] Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000901	PMA1 P05030	Physiology	Ser234Cys	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000902	PMA1 P05030	Physiology	Val127Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000903	PMA1 P05030	Physiology	Val157Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000904	PMA1 P05030	Physiology	Gly294Val	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000905	PMA1 P05030	Physiology	Gly337Ser	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000906	PMA1 P05030	Physiology	Met530Ile	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000907	PMA1 P05030	Physiology	Pro535Thr	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000908	PMA1 P05030	Physiology	Iso564Thr	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000909	PMA1 P05030	Physiology	Ala732Val	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000910	PMA1 P05030	Physiology	Trp750Cys	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMR1	Metal tolerance (manganese)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Sadhu MJ; Bloom JS; Day L ; et al. (2016) CRISPR-directed mitotic recombination enables genetic mapping without crosses.	GP00000914	PMR1 P13586	Physiology	Leu548Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMR1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PPAR-delta	Ear size Skin aspect	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Ren J; Duan Y; Qiao R ; et al. (2011) A missense mutation in PPARD causes a major QTL effect on ear size in pigs.	GP00000919	PPARD Q03181	Morphology Morphology	G32E	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		PPAR-delta	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
PpeGID1c	Plant size (dwarfism)	Coding, SNP N	Prunus persica peach - (species) D	Domesticated	Linkage Mapping	Hollender CA; Hadiarto T; Srinivasan C ; et al. (2016) A brachytic dwarfism trait (dw) in peach trees is caused by a nonsense mutation within the gibberell[...]	GP00000920	GID1C Q940G6	Morphology	Trp162* (TGG>TAG) N	Prunus persica peach - (species)	Prunus persica peach - (species) D		PpeGID1c	Prunus persica peach - (species)	Published - Accepted by Curator
prodynorphin (PDYN)	Neuroendocronological homeostasis	Cis-regulatory, SNP	Homo sapiens human - (species)	Interspecific	Candidate Gene	Rockman MV; Hahn MW; Soranzo N ; et al. (2005) Ancient and recent positive selection transformed opioid cis-regulation in humans. 1 Additional References Babbitt CC; Silverman JS; Haygood R (2010) Multiple Functional Variants in cis Modulate PDYN Expression.	GP00000924	PDYN P01213	Physiology	up to 5 polymorphisms in 5' regulatory region	Primates (order)	Homo sapiens human - (species)		prodynorphin (PDYN)	Homo sapiens human - (species)	Published - Accepted by Curator
Prolactin (deciduous Prolactin; dPRL)	Gene expression change (quantitative; increase)	Cis-regulatory, SNP	Homininae (subfamily)	Intergeneric or Higher	Candidate Gene	Emera D; Wagner GP (2012) Transformation of a transposon into a derived prolactin promoter with function during human pregnanc[...]	GP00000926	PRL P01236	Physiology	Acquisition of enhancer activity in transposons via several base-pair substitutions	Primates (order)	Homininae (subfamily)		Prolactin (deciduous Prolactin; dPRL)	Homininae (subfamily)	Published - Accepted by Curator
Prolactin receptor	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Candidate Gene	Viitala S; Szyda J; Blott S ; et al. (2006) The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...]	GP00000927	PRLR P16471	Physiology	Ser18Asn	Bos taurus cattle - (species)	Bos taurus cattle - (species)		Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	2 Mutations: Coding SNP N	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000931	PRR37 Q0D3B6	Physiology	2 mutations	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)		PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	Coding, SNP	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000932	PRR37 Q0D3B6	Physiology	K162N	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)		PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PsbHLH = A	Coloration (flowers)	Coding, SNP N	Pisum sativum pea - (species)	Domesticated	Linkage Mapping	Hellens RP; Moreau C; Lin-Wang K ; et al. (2010) Identification of Mendel's white flower character.	GP00000935	BHLH E3SXU4	Morphology	Splice site mutation: a simple G to A transition in a splice donor site that leads to a mis-spliced mRNA with a premature stop codon N	Pisum sativum pea - (species)	Pisum sativum pea - (species)		PsbHLH = A	Pisum sativum pea - (species)	Published - Accepted by Curator
PSMB7	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies)	Domesticated	Linkage Mapping	Clark LA; Tsai KL; Starr AN ; et al. (2011) A missense mutation in the 20S proteasome β2 subunit of Great Danes having harlequin coat patterning[...]	GP00000936	Psmb7 P70195	Morphology	Val49Gly	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies)		PSMB7	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Q = wheat AP2-like (WAP2)	Inflorescence morphology Spike morphology	Coding, SNP	Triticum turgidum (species)	Domesticated	Linkage Mapping	Simons KJ; Fellers JP; Trick HN ; et al. (2006) Molecular characterization of the major wheat domestication gene Q.	GP00000940	WANT1 C1PH82	Morphology Morphology	V329I	Triticum turgidum (species)	Triticum turgidum (species)		Q = wheat AP2-like (WAP2)	Triticum turgidum (species)	Published - Accepted by Curator
qSH1	Seed shattering	Cis-regulatory, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Konishi S; Izawa T; Lin SY ; et al. (2006) An SNP caused loss of seed shattering during rice domestication.	GP00000942	qSH1 Q941S9	Physiology	1bp change	Oryza sativa rice - (species)	Oryza sativa rice - (species)		qSH1	Oryza sativa rice - (species)	Published - Accepted by Curator
qSH1 (REPLUMLESS)	Seed shattering	Cis-regulatory, SNP	Brassicaceae mustard family - (family)	Interspecific	Candidate Gene	Arnaud N; Lawrenson T; Østergaard L ; et al. (2011) The same regulatory point mutation changed seed-dispersal structures in evolution and domestication.	GP00000943	qSH1 Q941S9	Physiology	1bp change	Brassicaceae mustard family - (family)	Brassicaceae mustard family - (family)		qSH1 (REPLUMLESS)	Brassicaceae mustard family - (family)	Published - Accepted by Curator
R/glyma09g36983	Coloration (seeds)	Coding, SNP N	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Gillman JD; Tetlow A; Lee JD ; et al. (2011) Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in [...] 1 Additional References Zabala G; Vodkin LO (2014) Methylation affects transposition and splicing of a large CACTA transposon from a MYB transcription [...]	GP00000946	100780023 K7LFP2	Morphology	C377- creating premature Stop N	Glycine max soybean - (species)	Glycine max soybean - (species)		R/glyma09g36983	Glycine max soybean - (species)	Published - Accepted by Curator
RAD5	Xenobiotic resistance	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Demogines A; Smith E; Kruglyak L ; et al. (2008) Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. 1 Additional References Ehrenreich IM; Torabi N; Jia Y (2010) Dissection of genetically complex traits with extremely large pools of yeast segregants.	GP00000950	RAD5 P32849	Physiology	I791S	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		RAD5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000952	RAS2 P01120	Physiology	Glu>Ala (A>C mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RAS1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS1	Salt tolerance Abscisic acid sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ren Z; Zheng Z; Chinnusamy V ; et al. (2010) RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis.	GP00000953	RAS1 O04515	Physiology Physiology	Premature stop codon; Lys>STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RAS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RAS2	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000954	RAS2 P01120	Physiology	Gly>Ser (C>T mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RAS2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS2	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000955	RAS2 P01120	Physiology	Glu>Gln (C>G mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RAS2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Rc	Coloration (seed)	Coding, SNP N	Oryza glaberrima African rice - (species)	Domesticated	Candidate Gene	Gross BL; Steffen FT; Olsen KM (2010) The molecular basis of white pericarps in African domesticated rice: novel mutations at the Rc gene.	GP00000958	Rc A7J5U6	Morphology	Premature stop codon in exon 7; Lys>* N	Oryza glaberrima African rice - (species)	Oryza glaberrima African rice - (species)		Rc	Oryza glaberrima African rice - (species)	Published - Accepted by Curator
Rc	Coloration (seed)	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sweeney MT; Thomson MJ; Cho YG ; et al. (2007) Global dissemination of a single mutation conferring white pericarp in rice. 2 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Sweeney MT; Thomson MJ; Pfeil BE (2006) Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice.	GP00000960	Rc A7J5U6	Morphology	substitution; C->A in exon 6; introduces a premature stop codon (Cys>*) that truncates the protein before the bHLH domain N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Rc	Oryza sativa rice - (species)	Published - Accepted by Curator
RCR3	Pathogen resistance	Coding, SNP	Solanum peruvianum (species)	Intraspecific	Candidate Gene	Hörger AC; Ilyas M; Stephan W ; et al. (2012) Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathog[...]	GP00000963	Rcr3 Q8S333	Physiology	Candidate amino acid changes are I206K and/or Q222E and/or S330A	Solanum peruvianum (species)	Solanum peruvianum (species)		RCR3	Solanum peruvianum (species)	Published - Accepted by Curator
Rds2	Oxidative stress resistance	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Diezmann S; Dietrich FS (2011) Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major qu[...]	GP00000964	RDS2 P19541	Physiology	H251D	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		Rds2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Reduced height-B1 (RhtB1)	Plant size (dwarfism)	Coding, SNP N	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Peng J; Richards DE; Hartley NM ; et al. (1999) 'Green revolution' genes encode mutant gibberellin response modulators.	GP00000965	D8 Q9ST48	Morphology	Q64*; TGA>CGA N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Reduced height-B1 (RhtB1)	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
Reduced height-D1 (RhtD1)	Plant size (dwarfism)	Coding, SNP N	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Peng J; Richards DE; Hartley NM ; et al. (1999) 'Green revolution' genes encode mutant gibberellin response modulators.	GP00000966	D8 Q9ST48	Morphology	E61*; GGA>TGA N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Reduced height-D1 (RhtD1)	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Thompson M; Shotkoski F; ffrench-Constant R (1993) Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]	GP00000968	Rdl P25123	Physiology	Ala302Ser	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		resistance to dieldrin	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species) D	Intraspecific	Candidate Gene	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000969	Rdl P25123	Physiology	Ala302Ser	Anopheles arabiensis (species)	Anopheles arabiensis (species) D		resistance to dieldrin	Anopheles arabiensis (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000970	Rdl P25123	Physiology	Ala302Gly	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		resistance to dieldrin	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Alon M; Alon F; Nauen R ; et al. (2008) Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associat[...]	GP00000971	Rdl P25123	Physiology	Ala302Ser	Bemisia tabaci (species)	Bemisia tabaci (species) D		resistance to dieldrin	Bemisia tabaci (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Kaku K; Matsumura F (1994) Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]	GP00000972	Rdl P25123	Physiology	Ala302Ser	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		resistance to dieldrin	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]	GP00000973	Rdl P25123	Physiology	Ala302Ser	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		resistance to dieldrin	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993) A point mutation in a Drosophila GABA receptor confers insecticide resistance. 2 Additional References Lee HJ; Rocheleau T; Zhang HG (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000974	Rdl P25123	Physiology	Ala302Ser - G9155164T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Rdl P25123	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Hypothenemus hampei coffee berry borer - (species) D	Intraspecific	Candidate Gene	Brun LO; Stuart J; Gaudichon V ; et al. (1995) Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...]	GP00000977	Rdl P25123	Physiology	Ala302Ser	Hypothenemus hampei coffee berry borer - (species)	Hypothenemus hampei coffee berry borer - (species) D		resistance to dieldrin	Hypothenemus hampei coffee berry borer - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000978	Rdl P25123	Physiology	Ala302Ser	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		resistance to dieldrin	Musca domestica house fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anthony N; Unruh T; Ganser D ; et al. (1998) Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.	GP00000979	Rdl P25123	Physiology	Ala302Gly	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		resistance to dieldrin	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Periplaneta americana American cockroach - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000980	Rdl P25123	Physiology	Ala302Ser	Periplaneta americana American cockroach - (species)	Periplaneta americana American cockroach - (species) D		resistance to dieldrin	Periplaneta americana American cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Tribolium castaneum red flour beetle - (species)	Intraspecific	Candidate Gene	Miyazaki M; Matsumura F; Beeman RW (1995) DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...] 1 Additional References Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000981	Rdl P25123	Physiology	Ala302Ser	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species)		resistance to dieldrin	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
resistant to methyl viologen 1 (RMV1)	Polyamine uptake	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Fujita M; Fujita Y; Iuchi S ; et al. (2012) Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis.	GP00000982	RMV1 Q9FFL1	Physiology	Ile377Phe N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		resistant to methyl viologen 1 (RMV1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
retr02/eIF(iso)4E	Pathogen resistance (plant virus)	Coding, SNP	Brassica rapa field mustard - (species) D	Domesticated	Linkage Mapping	Qian W; Zhang S; Zhang S ; et al. (2013) Mapping and candidate-gene screening of the novel Turnip mosaic virus resistance gene retr02 in Chin[...]	GP00000983	EIF(ISO)4E O04663	Physiology	G152R	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species) D		retr02/eIF(iso)4E	Brassica rapa field mustard - (species)	Published - Accepted by Curator
ribonuclease 1B (RNase1B)	Optimal enzymatic pH	3 Mutations: Coding SNP	Pygathrix nemaeus Red shanked douc langur - (species) D	Intergeneric or Higher	Candidate Gene	Zhang J (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.	GP00000987	RNASE1B Q8SPN3	Physiology	3 mutations	Primates (order)	Pygathrix nemaeus Red shanked douc langur - (species) D		ribonuclease 1B (RNase1B)	Pygathrix nemaeus Red shanked douc langur - (species)	Published - Accepted by Curator
ribonuclease 1B (RNase1B)	Optimal enzymatic pH	3 Mutations: Coding SNP	Colobus guereza mantled guereza - (species)	Intergeneric or Higher	Candidate Gene	Zhang J (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.	GP00000988	RNASE1B Q8SPN3	Physiology	3 mutations	Primates (order)	Colobus guereza mantled guereza - (species)		ribonuclease 1B (RNase1B)	Colobus guereza mantled guereza - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Caicedo AL; Schaal BA; Kunkel BN (1999) Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.	GP00001012	RPS2 Q42484	Physiology	W235* due to G704A N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RRS1	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Birker D; Heidrich K; Takahara H (2009) A locus conferring resistance to Colletotrichum higginsianum is shared by four geographically distin[...]	GP00001015	RRS1 P0DKH5	Physiology	Premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RRS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RSF1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00001016	HFR1 Q9FE22	Physiology	D181G	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		RSF1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
S5	Hybrid incompatibility (F1 female sterility)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Chen J; Ding J; Ouyang Y ; et al. (2008) A triallelic system of S5 is a major regulator of the reproductive barrier and compatibility of indi[...]	GP00001020	GRXS5 Q5QLR2	Physiology	2 non-synonymous changes Leu273Phe and Val471Ala segregate perfectly between japonica (Leu-Val) and japonica (Phe-Ala) - the effect of each amino acid chaeg has not been tested	Oryza sativa rice - (species)	Oryza sativa rice - (species)		S5	Oryza sativa rice - (species)	Published - Accepted by Curator
SBNO1	Head size	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Taal HR; Pourcain BS; Thiering E ; et al. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference.	GP00001023	SBNO1 A3KN83	Morphology	Ser729Asn	Homo sapiens human - (species)	Homo sapiens human - (species)		SBNO1	Homo sapiens human - (species)	Published - Accepted by Curator
scd-2	Diapause	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Reiner DJ; Ailion M; Thomas JH ; et al. (2008) C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]	GP00001026	scd-2 O76411	Physiology	Gly985Arg	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		scd-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (height)	2 Mutations: Coding SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Asano K; Yamasaki M; Takuno S ; et al. (2011) Artificial selection for a green revolution gene during japonica rice domestication.	GP00001027	GA20OX2 Q0JH50	Morphology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice.	GP00001029	GA20OX2 Q0JH50	Morphology	G94V	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice.	GP00001030	GA20OX2 Q0JH50	Morphology	D349H	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice.	GP00001031	GA20OX2 Q0JH50	Morphology	L266F	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
self-pruning (sp)	Vegetative/Reproductive state switch	Coding, SNP	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Pnueli L; Carmel-Goren L; Hareven D ; et al. (1998) The SELF-PRUNING gene of tomato regulates vegetative to reproductive switching of sympodial meristem[...]	GP00001035	SP O82088	Morphology	P76L due to CCT->CTT	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D		self-pruning (sp)	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Shattering1 - Sh1	Seed shattering	Coding, SNP	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Lin Z; Li X; Shannon LM ; et al. (2012) Parallel domestication of the Shattering1 genes in cereals.	GP00001042	YAB2 Q10FZ7	Physiology	GT-to-GG splice-site variant	Sorghum virgatum (species)	Sorghum bicolor sorghum - (species)		Shattering1 - Sh1	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
shattering4 - sh4	Seed shattering	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Li C; Zhou A; Sang T (2006) Rice domestication by reducing shattering.	GP00001046	sh4 Q1PIH9	Physiology	Asn -> Lys	Oryza rufipogon (species)	Oryza sativa rice - (species)		shattering4 - sh4	Oryza sativa rice - (species)	Published - Accepted by Curator
SHELL	Fruit shell thickness	Coding, SNP	Elaeis guineensis African oil palm - (species)	Domesticated	Linkage Mapping	Singh R; Low ET; Ooi LC ; et al. (2013) The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK.	GP00001047	AGL11 Q38836	Morphology	1a.a substitution in DNA binding domain	Elaeis guineensis African oil palm - (species)	Elaeis guineensis African oil palm - (species)		SHELL	Elaeis guineensis African oil palm - (species)	Published - Accepted by Curator
SHELL	Fruit shell thickness	Coding, SNP	Elaeis guineensis African oil palm - (species)	Domesticated	Candidate Gene	Singh R; Low ET; Ooi LC ; et al. (2013) The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK.	GP00001048	AGL11 Q38836	Morphology	1a.a substitution in DNA binding domain	Elaeis guineensis African oil palm - (species)	Elaeis guineensis African oil palm - (species)		SHELL	Elaeis guineensis African oil palm - (species)	Published - Accepted by Curator
SHMT / Rgh4	Pathogen resistance (cyst nematode; parasite)	2 Mutations: Coding SNP	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Liu S; Kandoth PK; Warren SD ; et al. (2012) A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens.	GP00001049	SHMT K4FZF8	Physiology	2 mutations	Glycine max soybean - (species)	Glycine max soybean - (species)		SHMT / Rgh4	Glycine max soybean - (species)	Published - Accepted by Curator
SIR2	Longevity	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00001054	SIR2 P06700	Physiology	1 to 5 amino-acid substitutions	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		SIR2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SKC1 =OsHKT1	Salt tolerance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Ren ZH; Gao JP; Li LG ; et al. (2