Gephebase

Gephebase Search Results

This Summary Table shows only the major fields for each entry. If you are interested in other fields (gene synonyms, GO terms, molecular details of the mutation, comments, etc.), please export the .csv file, which contains the complete data for each entry. Please click on a GepheID if you want to see all information regarding a particular entry.

Advanced Search

Field

Term

Summary Table

Your research retrieved 1251 results.

Summary
Others

Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Main Curator	Edit Gene-GePhe	Taxon B	Status	Date of Sent Email
18-wheeler	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00000001	18w A1ZBR2	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		18-wheeler	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ABC transporter pvmrp1	Xenobiotic resistance (multiresistance to antimalarial drugs)	Unknown, Unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001486	PVX_097025 A5KCN4	Physiology	unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species)		ABC transporter pvmrp1	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Indel N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000002	ABCA2 A0A0S0G7V0	Physiology	65bp indel in exon16 inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000003	ABCA2 A0A0S0G7V0	Physiology	5bp deletion inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000004	ABCA2 A0A0S0G7V0	Physiology	5bp (GAATA) nucleotide duplication inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002054	ABCA2 A0A0S0G7V0	Physiology	insertion of a transposon Tntransib (2581 bp) in ABCA2 which changes splicing sites in the transcript and lead to an indel in the coding region: change of 1551VETLAHALGFLRHLDKR1567 into 1551AHWGK- LYGSNTQN1563 N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D		ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00002056	ABCA2 A0A0S0G7V0	Physiology	14bp deletion resulting in missense mutations. N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D		ABCA2	Helicoverpa punctigera (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Candidate Gene	Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018) ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]	GP00002057	ABCA2 A0A0S0G7V0	Physiology	loss of exon 6 caused by alternative splicing N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		ABCA2	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002467	ABCA2 Q9BZC7	Physiology	insertion of a 2581-bp transposon Tntransib in ABCA2. This insertion disrupts splicing sites and leads to indels in the protein sequence. CRISPR ABCA2 mutants are highly resistant to Cry2Ab. N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D		ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCB1	Xenobiotic resistance (insecticide; Bt Cry3Aa toxin)	Coding, Deletion N	Chrysomela tremula (species) D	Intraspecific	Candidate Gene	Pauchet Y; Bretschneider A; Augustin S ; et al. (2016) A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle[...]	GP00002466	ABCB1 P08183	Physiology	a four-base-pair deletion at position 1561 introducing a frame shift with a premature stop codon leading to loss of the TpM1 transporter motif as well as the complete second transmembrane domain N	Chrysomela tremula (species)	Chrysomela tremula (species) D		ABCB1	Chrysomela tremula (species)	Published - Accepted by Curator
ABCB4	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Bariami V; Jones CM; Poupardin R ; et al. (2012) Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]	GP00002607	Abcb4 P21440	Physiology	ABCB4 gene amplified about 6–7 times	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		ABCB4	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
ABCB7	Iron metabolism	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001379	ABCB7 O75027	Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		ABCB7	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
ABCC11	Apocrine secretion (ear wax type ; axillary odor)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Yoshiura K; Kinoshita A; Ishida T ; et al. (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. 1 Additional References Martin A; Saathoff M; Kuhn F (2010) A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.	GP00000010	ABCC11 Q96J66	Physiology	1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette	Homo sapiens human - (species)	Homo sapiens human - (species)		ABCC11	Homo sapiens human - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Unknown, Unknown	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000014	ABCC2 A0A0E3ZDK3	Physiology	Not identified	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D		ABCC2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Deletion N	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014) ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]	GP00001439		Physiology	About 500 nt genomic deletion over 2 exons involving 246 nt coding 82aa N	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		ABCC2	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Banerjee R; Hasler J; Meagher R ; et al. (2017) Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm[...] 1 Additional References Flagel L; Lee YW; Wanjugi H (2018) Mutational disruption of the ABCC2 gene in fall armyworm, Spodoptera frugiperda, confers resistance [...]	GP00002461	MRP1 H8YF43	Physiology	A nine-base deletion (position 39–47) and a two-base insertion (GC at position 2218) lead to a frameshift and the occurrence of a premature stop codon. The truncated protein is 746 amino acids whereas the ABCC2 of the susceptible strain encodes a protein of 1349 amino acids. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D		ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Boaventura D; Ulrich J; Lueke B ; et al. (2020) Molecular characterization of Cry1F resistance in fall armyworm, Spodoptera frugiperda from Brazil.	GP00002462	MRP1 H8YF43	Physiology	two mutations in the extracellular loop 4 (ECL4) of ABCC2: a deletion of two amino acids (GY) at positions 788 and 789 and the change of a proline to either lysine or arginine at position 799. Expression of mutated ABCC2 in insect cells confirmed the role of these mutations in toxin binding. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D		ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
Abdominal-B	Coloration (male-specific)	Unknown, Unknown	Drosophila malerkotliana (species)	Intraspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001548	Abd-B P09087	Morphology	unknown	Drosophila malerkotliana (species)	Drosophila malerkotliana (species)		Abdominal-B	Drosophila malerkotliana (species)	Published - Accepted by Curator
Abdominal-B	Coloration (abdomen; setae)	Cis-regulatory, Unknown	Bombus melanopygus (species)	Intraspecific	Association Mapping	Tian L; Rahman SR; Ezray BD ; et al. (2019) A homeotic shift late in development drives mimetic color variation in a bumble bee.	GP00002048	Abd-B P09087	Morphology	4kb region - probably several mutations according to recombinants with intermediate phenotypes	Bombus melanopygus (species)	Bombus melanopygus (species)		Abdominal-B	Bombus melanopygus (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000017	ABO P16442	Physiology	Gly268 (group A) <-> Ala (group B)	Homininae (subfamily)	Homininae (subfamily)		ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000018	ABO P16442	Physiology	Leu266 (group A) <-> Met (group B)	Homininae (subfamily)	Homininae (subfamily)		ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Calafell F; Roubinet F; Ramírez-Soriano A (2008) Evolutionary dynamics of the human ABO gene.	GP00000019	ABO P16442	Physiology	1bp deletion (258G) resulting in frameshift N	Homo sapiens human - (species)	Homo sapiens human - (species) D		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993) Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000020	ABO P16442	Physiology	Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function) two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.	Homo sapiens human - (species)	Homo sapiens human - (species)		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000021	ABO P16442	Physiology	1bp insertion resulting in premature stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species) D		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000022	ABO P16442	Physiology	1bp change resulting in stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species)		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000023	ABO P16442	Physiology	Uncertain; possibly 9bp deletion resultin in 3a.a. deletion	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)		ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Unknown, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000024	ABO P16442	Physiology	unknown	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)		ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ACD6 = ACCELERATED CELL DEATH 6	Plant size Pathogen resistance (plant microbes) Herbivore resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Todesco M; Balasubramanian S; Hu TT ; et al. (2010) Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana. 1 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.	GP00000025	ACD6 Q8LPS2	Physiology Physiology Physiology	Various	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ACD6 = ACCELERATED CELL DEATH 6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; cyclic ketoenol)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Lueke B; Douris V; Hopkinson JE ; et al. (2020) Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated[...] 1 Additional References Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002513	ACC Q7JV23	Physiology	A2083V	Bemisia tabaci (species)	Bemisia tabaci (species) D		acetyl-CoA carboxylase (ACC)	Bemisia tabaci (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spiromesifen)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species) D	Intraspecific	Candidate Gene	Karatolos N; Williamson MS; Denholm I ; et al. (2012) Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid repla[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002556	ACC Q7JV23	Physiology	E645K	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species) D		acetyl-CoA carboxylase (ACC)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]	GP00002616	ACC Q7JV23	Physiology	a single non-synonymous mutation (gCt > gTt) resulting in an alanine to valine substitution in a highly conserved region of the ACC carboxyltransferase (CT) domain	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		acetyl-CoA carboxylase (ACC)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D		Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00000030	Ace P07140	Physiology	F331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D		Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D		Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...] 4 Additional References Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Carletto J; Martin T; Vanlerberghe-Masutti F (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii. Benting J; Nauen R (2004) Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates res[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)		Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...] 1 Additional References Assogba BS; Djogbénou LS; Milesi P (2015) An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, [...]	GP00001372	Ace P07140	Physiology	Strict tandem duplication of 203kb encompassing 12 genes ; ace1 heterogeneous gene duplication (susceptible G119 and resistant S119 copies)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species)	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001373	Ace P07140	Physiology	Strict tandem 3 times duplication of 203kb encompassing 12 genes with partial internal deletion of 97kb in the third copy - ace1 homogeneous gene duplications (all 3 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species)		Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001374	Ace P07140	Physiology	Strict tandem 5 times duplication of 203kb encompassing 12 genes - ace1 homogeneous gene duplications (all 5 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Nieuwenhuyse P; Demaeght P (2011) Acaricide resistance and resistance mechanisms in Tetranychus urticae populations from rose greenhou[...]	GP00002013	Ace P07140	Physiology	A201S	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Nabeshima T; Kozaki T; Tomita T ; et al. (2003) An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of[...]	GP00002015	Ace P07140	Physiology	Ser431Phe (position 331 in mature Torpedo protein)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		Acetylcholinesterase (Ace-1)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Jiang X; Qu M; Denholm I ; et al. (2009) Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]	GP00002453	Ace P07140	Physiology	an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D		Acetylcholinesterase (Ace-1)	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Lee DW; Choi JY; Kim WT ; et al. (2007) Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.). 3 Additional References Yeh SC; Lin CL; Chang C (2014) Amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos [...] Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Zhang LJ; Jing YP; Li XH (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...]	GP00002454	Ace P07140	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002512	Ace P07140	Physiology	F331W	Bemisia tabaci (species)	Bemisia tabaci (species) D		Acetylcholinesterase (Ace-1)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002571	Ace P07140	Physiology	S119G	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Leeuwen T; Grispou M (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...]	GP00002572	Ace P07140	Physiology	G328A	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Khajehali J; Van Leeuwen T; Grispou M ; et al. (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002573	Ace P07140	Physiology	F331W	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002574	Ace P07140	Physiology	D128E	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Li F; Han Z (2004) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 3 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00002577	Ace P07140	Physiology	A201S	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)		Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Reyes M; Rault M ; et al. (2006) Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002580	Ace P07140	Physiology	F399V = F290V	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D		Acetylcholinesterase (Ace-1)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Hadjivassilis A ; et al. (2007) A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipi[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002581	Ace P07140	Physiology	F290V	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002587	Ace P07140	Physiology	S329(228)P	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D		Acetylcholinesterase (Ace-1)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002589	Ace P07140	Physiology	F330S	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002590	Ace P07140	Physiology	F331H	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus kanzawai (species) D	Intraspecific	Candidate Gene	Aiki Yasuhiko; Kozaki Toshinori; Mizuno Hiroshi ; et al. (2005 ) Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resist[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002591	Ace P07140	Physiology	F331W	Tetranychus kanzawai (species)	Tetranychus kanzawai (species) D		Acetylcholinesterase (Ace-1)	Tetranychus kanzawai (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002592	Ace P07140	Physiology	F331C	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Candidate Gene	Carvalho Renato; Yang Yihua; Field Linda M ; et al. (2012 ) Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002593	Ace P07140	Physiology	F331W/Y	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Zhang Yueliang; Li Shuo; Xu Lu ; et al. (2013 ) Overexpression of carboxylesterase-1 and mutation (F439H) of acetylcholinesterase-1 are associated w[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002594	Ace P07140	Physiology	F331H	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D		Acetylcholinesterase (Ace-1)	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002595	Ace P07140	Physiology	L336S	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D		Acetylcholinesterase (Ace-1)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Zhang LJ; Jing YP; Li XH ; et al. (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002598	Ace P07140	Physiology	A441G	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	4 Mutations: Coding SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. 2 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Menozzi P; Shi MA; Lougarre A (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002011	Ace P07140	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00002012	Ace P07140	Physiology	Ile199Thr (position 129 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002016	Ace P07140	Physiology	Gly368Ala (position 328 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes - GGC>GCC	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002565	Ace P07140	Physiology	Phe392Trp mutation located in the acyl pocket of the active site gorge and recently shown to confer OP insensitivity in Culex tritaeniorhynchus	Bemisia tabaci (species)	Bemisia tabaci (species) D		Acetylcholinesterase (Ace-2)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002568	Ace P07140	Physiology	E73G	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Li Fei; Han Zhaojun (2004 ) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002569	Ace P07140	Physiology	F78L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		Acetylcholinesterase (Ace-2)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002570	Ace P07140	Physiology	E81K	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Kozaki T; Shono T; Tomita T ; et al. (2001) Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002575	Ace P07140	Physiology	I129V	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002576	Ace P07140	Physiology	I129V	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Temeyer KB; Li AY; Lohmeyer KH ; et al. (2008) Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002578	Ace P07140	Physiology	G227A	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		Acetylcholinesterase (Ace-2)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002579	Ace P07140	Physiology	S238G	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace-2)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002582	Ace P07140	Physiology	F290Y	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]	GP00002583	Ace P07140	Physiology	F466Y	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D		Acetylcholinesterase (Ace-2)	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002585	Ace P07140	Physiology	F368(290)L	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D		Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002586	Ace P07140	Physiology	V435(356)A	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D		Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Ceratitis capitata Mediterranean fruit fly - (species) D	Intraspecific	Candidate Gene	Magaña C; Hernández-Crespo P; Brun-Barale A ; et al. (2008) Mechanisms of resistance to malathion in the medfly Ceratitis capitata. 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002588	Ace P07140	Physiology	Gly328Ala	Ceratitis capitata Mediterranean fruit fly - (species)	Ceratitis capitata Mediterranean fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Ceratitis capitata Mediterranean fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Nabeshima T; Mori A; Kozaki T ; et al. (2004) An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Ja[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002596	Ace P07140	Physiology	F331W - F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D		Acetylcholinesterase (Ace-2)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002597	Ace P07140	Physiology	W435R	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D		Acetylcholinesterase (Ace-2)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, Deletion	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008) A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...] 1 Additional References Kakani EG; Bon S; Massoulié J (2011) Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides.	GP00000038	Ace P07140	Physiology	9bp deletion of three glutamine residues at positions 642_644	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Haymer DS; Wu WJ ; et al. (2006) Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]	GP00000045	Ace P07140	Physiology	2 mutations	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00002014	Ace P07140	Physiology	Ser>Gly (238 is the corresponding position in Torpedo)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (abdomen; female-limited)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Morgan AH ; et al. (2000) Both naturally occurring insertions of transposable elements and intermediate frequency polymorphism[...]	GP00000046	sc P10084	Morphology	transposon insertion in non-coding region	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		achaete-scute complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (abdomen)	Cis-regulatory, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Morgan AH ; et al. (2000) Both naturally occurring insertions of transposable elements and intermediate frequency polymorphism[...]	GP00000047	sc P10084	Morphology	indel MC21 in promoter region of scute	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		achaete-scute complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (thorax)	Cis-regulatory, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Gruber JD; Genissel A; Macdonald SJ ; et al. (2007) How repeatable are associations between polymorphisms in achaete-scute and bristle number variation [...]	GP00000048	sc P10084	Morphology	indel MC22 in promoter region of scute	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		achaete-scute complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ACS11	Plant architecture (petiole-to-leaf-length ratio)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Kooke R; Kruijer W; Bours R ; et al. (2016) Genome-Wide Association Mapping and Genomic Prediction Elucidate the Genetic Architecture of Morphol[...]	GP00001235	ACS11 Q9S9U6	Morphology	several candidate amino acid changes	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ACS11	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ADAMTS10	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000050	ADAMTS10 Q9H324	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		ADAMTS10	Homo sapiens human - (species)	Published - Accepted by Curator
adenosine deaminase (AgADA)	Pathogen resistance (parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001463	ADA P00813	Physiology	c.C427T p.R143C	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		adenosine deaminase (AgADA)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
AGAMOUS-LIKE 50	Leaf number (at flowering time)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Seymour DK; Chae E; Grimm DG ; et al. (2016) Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.	GP00001450	AGAMOUS-like 50 Q9XIE7	Morphology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AGAMOUS-LIKE 50	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AGAMOUS-Like6	Plant architecture Inflorescence architecture	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Huang X; Effgen S; Meyer RC ; et al. (2012) Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in[...]	GP00000053	AGL6 P29386	Morphology Morphology	Pro201Leu	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AGAMOUS-Like6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Gene Loss, Deletion N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000055	Asip Q03288	Morphology	125kb deletion including 5' CDS of Agouti N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Coding, SNP N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000056	Asip Q03288	Morphology	Premature stop codon at residue 65 N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Cis-regulatory, Unknown	Peromyscus polionotus leucocephalus (subspecies) D Peromyscus polionotus niveiventris (subspecies) D Peromyscus polionotus peninsularis (subspecies) D Peromyscus polionotus allophrys (subspecies) D Peromyscus polionotus trissyllepsis (subspecies) D Peromyscus polionotus ammobates (subspecies) D Peromyscus polionotus albifrons (subspecies) D Peromyscus polionotus subgriseus (subspecies) D	Intraspecific	Linkage Mapping	Manceau M; Domingues VS; Mallarino R ; et al. (2011) The developmental role of Agouti in color pattern evolution. 1 Additional References Wooldridge TB; Kautt AF; Lassance JM (2022) An enhancer of Agouti contributes to parallel evolution of cryptically colored beach mice.	GP00000057	Asip Q03288	Morphology	"A closer investigation of this region revealed three SNPs significantly associated with pigment variation, spanning 1,756 bp, in strong linkage disequilibrium (mean r2 = 0.85). A single SNP on chromosome 4 (chr4) at position chr4: 9,845,301 showed a markedly stronger association with pPC1 than the other two (Fig. 3B). This SNP is located between two untranslated exons (exons 1D and 1E), is 120 bp upstream of a cluster of Short Interspersed Nuclear Elements (SINE) in reverse orientation relative to the transcription of Agouti, and is 5,641 bp upstream of the first coding exon (exon 2). " "Next, we employ an association-mapping approach to identify an ∼2-kb previously uncharacterized noncoding region of Agouti associated with color variation. We then show that this 2-kb region can drive dermal expression in Mus embryos, demonstrating its regulatory activity in the skin during the establishment of pigmentation."	Peromyscus polionotus subgriseus (subspecies) Peromyscus polionotus polionotus (subspecies) Peromyscus polionotus albifrons (subspecies)	Peromyscus polionotus leucocephalus (subspecies) D Peromyscus polionotus niveiventris (subspecies) D Peromyscus polionotus peninsularis (subspecies) D Peromyscus polionotus allophrys (subspecies) D Peromyscus polionotus trissyllepsis (subspecies) D Peromyscus polionotus ammobates (subspecies) D Peromyscus polionotus albifrons (subspecies) D Peromyscus polionotus subgriseus (subspecies) D		Agouti	Peromyscus polionotus leucocephalus (subspecies) Peromyscus polionotus niveiventris (subspecies) Peromyscus polionotus peninsularis (subspecies) Peromyscus polionotus allophrys (subspecies) Peromyscus polionotus trissyllepsis (subspecies) Peromyscus polionotus ammobates (subspecies) Peromyscus polionotus albifrons (subspecies) Peromyscus polionotus subgriseus (subspecies)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Intraspecific	Linkage Mapping	Rieder S; Taourit S; Mariat D ; et al. (2001) Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their associati[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000062	Asip Q03288	Morphology	11bp deletion in exon 2: g.2174_2184del11 c.191_201del N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Agouti	Equus caballus horse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Panthera pardus leopard - (species) D	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000065	Asip Q03288	Morphology	nonsense mutation located in exon 4 (C333A) predicted to introduce a stop codon at amino acid position 111 N	Panthera pardus leopard - (species)	Panthera pardus leopard - (species) D		Agouti	Panthera pardus leopard - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP	Catopuma temminckii Asiatic golden cat - (species)	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000066	Asip Q03288	Morphology	C128W (384C>G)	Catopuma temminckii Asiatic golden cat - (species)	Catopuma temminckii Asiatic golden cat - (species)		Agouti	Catopuma temminckii Asiatic golden cat - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Leopardus colocolo Colocolo - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001731	Asip Q03288	Morphology	Arg to Cys substitution in the C-terminal region of ASIP (p.R120C) lies in the critical RFF loop (e.g. a triplet motif made of one arginine and two phenylalanine residues) required for binding to the MC1R N	Leopardus colocolo Colocolo - (species)	Leopardus colocolo Colocolo - (species) D		Agouti	Leopardus colocolo Colocolo - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Leopardus guigna Kodkod - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001732	Asip Q03288	Morphology	Cys to Tyr substitution in ASIP (p.C126Y) which affects the key disulfide bond that stabilizes the RFF loop N	Leopardus guigna Kodkod - (species)	Leopardus guigna Kodkod - (species) D		Agouti	Leopardus guigna Kodkod - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	5 Mutations:	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Association Mapping	Linnen CR; Poh YP; Peterson BK ; et al. (2013) Adaptive evolution of multiple traits through multiple mutations at a single gene. 1 Additional References Barrett RDH; Laurent S; Mallarino R (2019) Linking a mutation to survival in wild mice.	GP00001974	Asip Q03288	Morphology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)		Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Gene Loss, Deletion N	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00001975	Asip Q03288	Morphology	125kb deletion ; recessive mutation N	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)		Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Association Mapping	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00001976	Asip Q03288	Morphology	recessive mutation at nucleotide position 193 (in exon 3) resulting in a change from glutamine to a stop codon at amino acid position 65 (Q65term) N	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)		Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP	Sciurus niger fox squirrel - (species) D	Intraspecific	Candidate Gene	McRobie HR; Moncrief ND; Mundy NI (2019) Multiple origins of melanism in two species of North American tree squirrel (Sciurus).	GP00002335		Morphology	Gly121Cys	Sciurus niger fox squirrel - (species)	Sciurus niger fox squirrel - (species) D		Agouti	Sciurus niger fox squirrel - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Cis-regulatory, Insertion	Mus musculus molossinus Japanese wild mouse - (subspecies) D	Intraspecific	Candidate Gene	Tanave A; Imai Y; Koide T (2019) Nested retrotransposition in the East Asian mouse genome causes the classical nonagouti mutation.	GP00002386	Asip Q03288	Morphology		Mus musculus molossinus Japanese wild mouse - (subspecies)	Mus musculus molossinus Japanese wild mouse - (subspecies) D		Agouti	Mus musculus molossinus Japanese wild mouse - (subspecies)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (skin; hair)	Cis-regulatory, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Bonilla C; Boxill LA; Donald SA ; et al. (2005) The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with dar[...] 2 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2008) Two newly identified genetic determinants of pigmentation in Europeans. Voisey J; Gomez-Cabrera Mdel C; Smit DJ (2006) A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA.	GP00000070	Asip Q03288	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		Agouti (ASIP)	Homo sapiens human - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Monarcha castaneiventris Makira monarch - (species) D	Intraspecific	Association Mapping	Uy JA; Cooper EA; Cutie S ; et al. (2016) Mutations in different pigmentation genes are associated with parallel melanism in island flycatcher[...]	GP00001334	Asip Q03288	Morphology	Ile55Thr	Monarcha castaneiventris Makira monarch - (species)	Monarcha castaneiventris Makira monarch - (species) D		Agouti (ASIP)	Monarcha castaneiventris Makira monarch - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat) Lifespan	2 Mutations: Coding N	Ovis aries sheep - (species) D	Intraspecific	Linkage Mapping	Gratten J; Pilkington JG; Brown EA ; et al. (2010) The genetic basis of recessive self-colour pattern in a wild sheep population. 1 Additional References Gratten J; Pilkington JG; Brown EA (2012) Selection and microevolution of coat pattern are cryptic in a wild population of sheep.	GP00001356	Asip Q03288	Morphology Physiology	2 mutations	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		Agouti (ASIP)	Ovis aries sheep - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Deletion N	D	Intraspecific	Candidate Gene	Miller SM; Guthrie AJ; Harper CK (2016) Single base-pair deletion in ASIP exon 3 associated with recessive black phenotype in impala (Aepyce[...]	GP00001977	Asip Q03288	Morphology	recessive c.174delA was found in all black phenotype sequences ; premature stop codon (239–241 bp) N		D		Agouti (ASIP)		Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Cis-regulatory, Unknown	Lepus americanus snowshoe hare - (species) D	Intraspecific	Association Mapping	Jones MR; Mills LS; Alves PC ; et al. (2018) Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares.	GP00002060	Asip Q03288	Morphology	exact mutation(s) unknown	Lepus americanus snowshoe hare - (species)	Lepus americanus snowshoe hare - (species) D		Agouti (ASIP)	Lepus americanus snowshoe hare - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Cis-regulatory, Unknown	Lepus timidus Mountain hare - (species) D	Intraspecific	Association Mapping	Giska I; Farelo L; Pimenta J ; et al. (2019) Introgression drives repeated evolution of winter coat color polymorphism in hares.	GP00002061	Asip Q03288	Morphology	exact mutation(s) unknown	Lepus timidus Mountain hare - (species)	Lepus timidus Mountain hare - (species) D		Agouti (ASIP)	Lepus timidus Mountain hare - (species)	Published - Accepted by Curator
agrecan	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000072	ACAN P16112	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		agrecan	Homo sapiens human - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (TCDD)	Coding, SNP N	Rattus norvegicus Norway rat - (species) D	Intraspecific	Linkage Mapping	Tuomisto JT; Viluksela M; Pohjanvirta R ; et al. (1999) The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resista[...] 2 Additional References Moffat ID; Roblin S; Harper PA (2007) Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transac[...] Pohjanvirta R; Wong JM; Li W (1998) Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon[...]	GP00001813	Ahr P30561	Physiology	point mutation in the exon/intron 10 boundary in AHR genomic structure that leads to use of 3 alternative cryptic splice sites; potentially creating 3 alternative transcripts and 2 protein products. At the protein level the mutation leads to a total loss of either 43 or 38 amino acids (with altered sequence for the last seven amino acids in the latter case) toward the carboxyl-terminal end in the trans-activation domain of the AhR. H/W rats also harbor a point mutation in exon 10 that will cause a Val-to-Ala substitution in codon 497, but this occurs in a variable region of the AhR N	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D		AHR	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001806	Ahr P30561	Physiology	70 kb deletion that removes parts of the two genes AHR1a and AHR2a N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D		AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001807	Ahr P30561	Physiology	45 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 5 of AHR2a to exon 4 of AHR1a) N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D		AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001808	Ahr P30561	Physiology	83 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 11 of AHR2a to exon 6 of AHR1a) N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D		AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution; polychlorinated biphenyls; PCBs)	Coding, Deletion N	Microgadus tomcod Atlantic tomcod - (species) D	Intraspecific	Candidate Gene	Wirgin I; Roy NK; Loftus M ; et al. (2011) Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.	GP00001809	Ahr P30561	Physiology	6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain N	Microgadus tomcod Atlantic tomcod - (species)	Microgadus tomcod Atlantic tomcod - (species) D		AHR2	Microgadus tomcod Atlantic tomcod - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus grandis Gulf killifish - (species) D	Intraspecific	Association Mapping	Oziolor EM; Reid NM; Yair S ; et al. (2019) Adaptive introgression enables evolutionary rescue from extreme environmental pollution.	GP00002669	Ahr P30561	Physiology	70 kb deletion that removes parts of the two genes AHR1a and AHR2a N	Fundulus grandis Gulf killifish - (species)	Fundulus grandis Gulf killifish - (species) D		AHR2	Fundulus grandis Gulf killifish - (species)	Published - Accepted by Curator
AIP	Xenobiotic resistance (pollution)	Unknown, Unknown N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.	GP00001812	Aip O08915	Physiology	exact mutation(s) unknown - very good candidate gene according to association mapping and knowledge about the physiology N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D		AIP	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AIP	Xenobiotic resistance (pollution)	Unknown, Unknown N	Fundulus grandis Gulf killifish - (species) D	Intraspecific	Association Mapping	Oziolor EM; Reid NM; Yair S ; et al. (2019) Adaptive introgression enables evolutionary rescue from extreme environmental pollution.	GP00002670	Aip O08915	Physiology	exact mutation(s) unknown - very good candidate gene according to Fst and knowledge about the physiology N	Fundulus grandis Gulf killifish - (species)	Fundulus grandis Gulf killifish - (species) D		AIP	Fundulus grandis Gulf killifish - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	6 Mutations:	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Choudhary M; Laurie CC (1991) Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...] 4 Additional References Laurie CC; Bridgham JT; Choudhary M (1991) Associations between DNA sequence variation and variation in expression of the Adh gene in natural p[...] King EG; Merkes CM; McNeil CL (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource. Siddiq MA; Loehlin DW; Montooth KL (2017) Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaste[...] Loehlin DW; Ames JR; Vaccaro K (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001962	Adh P00334	Physiology	6 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Vigue C; Sofer W (1974) Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.	GP00001988	Adh P00334	Physiology	Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Strand DJ; McDonald JF (1989) Insertion of a copia element 5' to the Drosophila melanogaster alcohol dehydrogenase gene (adh) is a[...]	GP00001989	Adh P00334	Physiology	insertion of a complete 5.2kb copia retroviral-like transposable element 240 bp upstream from the distal (adult) adh transcriptional start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Freeth AL; Gibson JB; Wilks AV (1990) Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...] 1 Additional References Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001990	Adh P00334	Physiology	eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001991	Adh P00334	Physiology	438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)	Xenobiotic resistance (alcohol)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Li H; Mukherjee N; Soundararajan U ; et al. (2007) Geographically separate increases in the frequency of the derived ADH1B47His allele in eastern and [...] 1 Additional References Li H; Mukherjee N; Soundararajan U (2007)* Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]	GP00000077	ADH1B P00325	Physiology	Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication	Homo sapiens human - (species)	Homo sapiens human - (species) D		alcohol dehydrogenase (ADH1B)	Homo sapiens human - (species)	Published - Accepted by Curator
Aldehyde dehydrogenase (Aldh)	Xenobiotic resistance (alcohol)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Fry JD; Donlon K; Saweikis M (2008) A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selectio[...]	GP00002007	Aldh Q9VLC5	Physiology	L479F C9391311T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Aldehyde dehydrogenase (Aldh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Allantoin permease DAL4	Nitrogen use (growth rate on allantoin)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001503	DAL4 Q04895	Physiology	c.1201delA a single nucleotide frameshifting insertion (deletion?) N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Allantoin permease DAL4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Allantoinase DAL1	Nitrogen use (growth rate on allantoin)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001502	DAL1 P32375	Physiology	c.415C>T p.P139S predicted to be strongly detrimental	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Allantoinase DAL1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001893	ALS P17597	Physiology	W574L	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001894	ALS P17597	Physiology	S653N	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001895	ALS P17597	Physiology	S653T	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
Amhr2	Sex determination (female vs male)	Coding, SNP	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Intraspecific	Linkage Mapping	Kamiya T; Kai W; Tasumi S ; et al. (2012) A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, [...]	GP00002147	AMHR2 Q16671	Physiology	His/Asp384 heterozygous males have reduced Amrh2 activity due to decreased activity of the kinase signaling domain	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)		Amhr2	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Published - Accepted by Curator
ammonium transporter 2;1	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001431	AMT2 Q9M6N7	Physiology	seven aa substitutions	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		ammonium transporter 2;1	Arabidopsis arenosa (species)	Published - Accepted by Curator
AMPD1 (=CG32626)	Drug resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kislukhin G; King EG; Walters KN ; et al. (2013) The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.	GP00000083	AMPD1 P23109	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		AMPD1 (=CG32626)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]	Drug resistance	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Wessels JA; van der Kooij SM; le Cessie S ; et al. (2007) A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset[...]	GP00000084	AMPD1 P23109	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]	Homo sapiens human - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Meles leucurus Asian badger - (species) D	Intraspecific	Candidate Gene	Abduriyim Shamshidin; Nishita Yoshinori; Abramov AV ; et al. (2019 ) Variation in pancreatic amylase gene copy number among Eurasian badgers (Carnivora, Mustelidae, Mele[...]	GP00001907	Amy1 P00687	Physiology	Copy Number Variation varies between one and four in this species	Meles leucurus Asian badger - (species)	Meles leucurus Asian badger - (species) D		amylase	Meles leucurus Asian badger - (species)	Published - Accepted by Curator
amylase 1 (AMY1)	Starch processing	Gene Amplification, Insertion	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Perry GH; Dominy NJ; Claw KG ; et al. (2007) Diet and the evolution of human amylase gene copy number variation. 2 Additional References Falchi M; El-Sayed Moustafa JS; Takousis P (2014) Low copy number of the salivary amylase gene predisposes to obesity. Pajic P; Pavlidis P; Dean K (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00000085	AMY1A P04745	Physiology	Probably gene duplication	Homo sapiens human - (species)	Homo sapiens human - (species) D		amylase 1 (AMY1)	Homo sapiens human - (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000089	AN2 A4GRU8	Morphology	1bp deletion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000090	AN2 A4GRU8	Morphology	4bp insertion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000091	AN2 A4GRU8	Morphology	W196* N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000092	AN2 A4GRU8	Morphology	1bp deletion; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
AOP2	Glucosinolate content	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000095	AOP2 Q945B5	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AOP2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AOP3	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000096	AOP3 Q9ZTA1	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AOP3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
apicoplast ribosomal protein S10	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001531	PF3D7_1460900.1 Q8IKM3	Physiology	p.Val127Met	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		apicoplast ribosomal protein S10	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
APL1 cluster	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Riehle MM; Markianos K; Niaré O ; et al. (2006) Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. 1 Additional References Rottschaefer SM; Riehle MM; Coulibaly B (2011) Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 mal[...]	GP00000098	APL1A L7RQU1	Physiology	Not identified	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		APL1 cluster	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
APOE (apolipoprotein E)	Aging	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000099	APOE P02649	Physiology	Cys112Arg	Homo sapiens human - (species)	Homo sapiens human - (species)		APOE (apolipoprotein E)	Homo sapiens human - (species)	Published - Accepted by Curator
APSR	Sulfate content (shoot)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007) Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.	GP00000100	APR2 P92981	Physiology	A399E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		APSR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
arcp-1	CO2 avoidance Aggregation behavior	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Beets I; Zhang G; Fenk LA ; et al. (2019) Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Alteri[...]	GP00002067	CELE_F34D10.6 C6KRH4	Behavior Behavior	8 bp deletion (mfP22) in the open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		arcp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
arginyl-transfer RNA synthetase (RARS)	Heat tolerance	Coding, SNP	Anolis cristatellus (species) D	Intraspecific	Association Mapping	Campbell-Staton SC; Winchell KM; Rochette NC ; et al. (2020) Parallel selection on thermal physiology facilitates repeated adaptation of city lizards to urban he[...]	GP00002620	RARS2 Q5T160	Physiology	C>G threonine>serine at amino acid residue 558 of the RARS gene = adjacent to a predicted protein-binding region22 (AA556–557). There are four non-synonymous polymorphic sites within RARS. Only one shows a significant difference in allele frequency between forest and urban habitats across all populations.	Anolis cristatellus (species)	Anolis cristatellus (species) D		arginyl-transfer RNA synthetase (RARS)	Anolis cristatellus (species)	Published - Accepted by Curator
ARHGAP11B	Neocortex development (basal progenitor amplification)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Florio M; Namba T; Pääbo S ; et al. (2016) A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.	GP00001442	ARHGAP11B Q3KRB8	Morphology	c.661C>G new splice site mutation removing 55nt from exon 5 truncating a GAP domain N	Homo sapiens human - (species)	Homo sapiens human - (species) D		ARHGAP11B	Homo sapiens human - (species)	Published - Accepted by Curator
ARHGEF3	Hematopoiesis (mean blood platelet volume & blood platelet count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001605	ARHGEF3 Q9NR81	Physiology	T>C at the associated SNP that disrupts a conserved GATA motif. This variant overlaps with a common-myeloid progenitor (CMP-) and megakaryocyte-erythroid progenitor (MEP-) specific regulatory element that affects the transcription of ARHGEF3	Homo sapiens human - (species)	Homo sapiens human - (species)		ARHGEF3	Homo sapiens human - (species)	Published - Accepted by Curator
aristaless	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius cydno (species) D	Intraspecific	Linkage Mapping	Westerman EL; VanKuren NW; Massardo D ; et al. (2018) Aristaless Controls Butterfly Wing Color Variation Used in Mimicry and Mate Choice.	GP00002059	al Q06453	Morphology	gain of expression - exact mutation unknown	Heliconius cydno (species)	Heliconius cydno (species) D		aristaless	Heliconius cydno (species)	Published - Accepted by Curator
ARNT-1c	Xenobiotic resistance (pollution)	Unknown, Unknown N	Fundulus grandis Gulf killifish - (species) D	Intraspecific	Association Mapping	Oziolor EM; Reid NM; Yair S ; et al. (2019) Adaptive introgression enables evolutionary rescue from extreme environmental pollution.	GP00002672	P27540NULL	Physiology	exact mutation(s) unknown - very good candidate gene according to high differentiation region on chromosome 8 and knowledge about the physiology. ARNT1c is a nuclear dimerization partner of aryl hydrocarbon receptor (AHR) required for activation of the xenobiotic response pathway. N	Fundulus grandis Gulf killifish - (species)	Fundulus grandis Gulf killifish - (species) D		ARNT-1c	Fundulus grandis Gulf killifish - (species)	Published - Accepted by Curator
ARNT-L2a	Xenobiotic resistance (pollution)	Unknown, Unknown N	Fundulus grandis Gulf killifish - (species) D	Intraspecific	Association Mapping	Oziolor EM; Reid NM; Yair S ; et al. (2019) Adaptive introgression enables evolutionary rescue from extreme environmental pollution.	GP00002671	P27540NULL	Physiology	exact mutation(s) unknown - very good candidate gene according to high differentiation region on chromosome 10 and knowledge about the physiology. ARNT-L2a is a nuclear dimerization partner of aryl hydrocarbon receptor (AHR) required for activation of the xenobiotic response pathway. N	Fundulus grandis Gulf killifish - (species)	Fundulus grandis Gulf killifish - (species) D		ARNT-L2a	Fundulus grandis Gulf killifish - (species)	Published - Accepted by Curator
arrow	Coloration (wing)	Cis-regulatory, Unknown	Danaus chrysippus African queen - (species)	Intraspecific	Association Mapping	Martin SH; Singh KS; Gordon IJ ; et al. (2020) Whole-chromosome hitchhiking driven by a male-killing endosymbiont.	GP00002431	cnn P54623	Morphology	The strongest associations with forewing tip (C locus) occur at the gene arrow and a phylogenetic network for a 100-kb region around this gene similarly clusters individuals by phenotype. In Drosophila Arrow is essential for Wnt signalling in wing development	Danaus chrysippus African queen - (species)	Danaus chrysippus African queen - (species)		arrow	Danaus chrysippus African queen - (species)	Published - Accepted by Curator
AT5G41740/AT5G41750	Hybrid incompatibility (auto-immune necrosis)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Bomblies K; Lempe J; Epple P ; et al. (2007) Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants.	GP00000105	MUF8.2 F4JYI4	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AT5G41740/AT5G41750	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Luo Y; Dong X; Yu T ; et al. (2015) A Single Nucleotide Deletion in Gibberellin20-oxidase1 Causes Alpine Dwarfism in Arabidopsis.	GP00001243	GA20OX1 Q39110	Morphology	-1bp at position 184 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtHKT1	Salt tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Rus A; Baxter I; Muthukumar B ; et al. (2006) Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. 1 Additional References Baxter I; Brazelton JN; Yu D (2010) A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the[...]	GP00000124	HKT1 Q84TI7	Physiology	725bp deletion of part of upstream repeat region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtHKT1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtHKT1	Salt tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Rus A; Baxter I; Muthukumar B ; et al. (2006) Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. 1 Additional References Baxter I; Brazelton JN; Yu D (2010) A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the[...]	GP00000125	HKT1 Q84TI7	Physiology	687bp deletion of part of upstream repeat region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtHKT1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtMYC1	Trichome density (leaf)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Symonds VV; Hatlestad G; Lloyd AM (2011) Natural allelic variation defines a role for ATMYC1: trichome cell fate determination. 1 Additional References Symonds VV; Godoy AV; Alconada T (2005) Mapping quantitative trait loci in multiple populations of Arabidopsis thaliana identifies natural a[...]	GP00001268	BHLH12 Q8W2F1	Morphology	P189A	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtMYC1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ATP2B4	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Timmann C; Thye T; Vens M ; et al. (2012) Genome-wide association study indicates two novel resistance loci for severe malaria.	GP00000127	ATP2B4 P23634	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		ATP2B4	Homo sapiens human - (species)	Published - Accepted by Curator
ATR13	Pathogenicity	Coding, SNP	Hyaloperonospora parasitica (species)	Intraspecific	Linkage Mapping	Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004) Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. 1 Additional References Allen RL; Meitz JC; Baumber RE (2008) Natural variation reveals key amino acids in a downy mildew effector that alters recognition specifi[...]	GP00000128	Atr13 Q5G7K8	Physiology	Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown	Hyaloperonospora parasitica (species)	Hyaloperonospora parasitica (species)		ATR13	Hyaloperonospora parasitica (species)	Published - Accepted by Curator
ATXN1	Body fat distribution (attenuation)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001552	ATXN1 P54253	Physiology	A>G in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		ATXN1	Homo sapiens human - (species)	Published - Accepted by Curator
avpr1a	Male sexual fidelity (monogamous regime)	Cis-regulatory, Unknown	Microtus ochrogaster prairie vole - (species)	Intraspecific	Candidate Gene	Okhovat M; Berrio A; Wallace G ; et al. (2015) Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain. 1 Additional References Berrio A; Guerrero RF; Aglyamova GV (2018) Complex selection on a regulator of social cognition: Evidence of balancing selection, regulatory in[...]	GP00000129	Avpr1a Q62463	Behavior	unknown	Microtus ochrogaster prairie vole - (species)	Microtus ochrogaster prairie vole - (species)		avpr1a	Microtus ochrogaster prairie vole - (species)	Published - Accepted by Curator
AZI1	Root growth (root growth responses to low zinc conditions)	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Bouain N; Satbhai SB; Korte A ; et al. (2018) Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition.	GP00001769	AZI1 Q9SU35	Physiology	exact causing mutation(s) unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AZI1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
bab	Coloration (abdomen ; sexual trait ; plasticity)	Cis-regulatory, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	De Castro S; Peronnet F; Gilles JF ; et al. (2018) bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity [...]	GP00002423	bab1 Q9W0K7	Morphology	a 56-bp deletion that removes two binding sites for Abdominal B (Abd-B), a direct activator of bab, is present in a cis-regulatiry region of bab1 (within the first intron of bab1) in the Dark line.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		bab	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
bab	Insect pheromone attraction	Cis-regulatory, Unknown	Ostrinia nubilalis European corn borer - (species)	Intraspecific	Association Mapping	Unbehend M; Kozak GM; Koutroumpa F ; et al. (2021) bric à brac controls sex pheromone choice by male European corn borer moths.	GP00002424	bab1 Q9W0K7	Behavior; Physiology	A genome-wide association study of pheromone preference under field conditions indicates that preference is controlled by sequence variation within the 293 kb bab intron 1.	Ostrinia nubilalis European corn borer - (species)	Ostrinia nubilalis European corn borer - (species)		bab	Ostrinia nubilalis European corn borer - (species)	Published - Accepted by Curator
bab	Coloration (abdomen; female)	2 Mutations: Cis-regulatory SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Rogers WA; Salomone JR; Tacy DJ ; et al. (2013) Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]	GP00002610	bab1 Q9W0K7	Morphology	2 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		bab	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
bab	Coloration (abdomen; female)	2 Mutations: Cis-regulatory SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Rogers WA; Salomone JR; Tacy DJ ; et al. (2013) Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]	GP00002611	bab1 Q9W0K7	Morphology	2 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		bab	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
bab1	Coloration (abdomen)	3 Mutations: Cis-regulatory Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kopp A; Graze RM; Xu S ; et al. (2003) Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanog[...] 1 Additional References Bickel RD; Kopp A; Nuzhdin SV (2011) Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL.	GP00000130	bab1 Q9W0K7	Morphology	3 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		bab1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
bab2	Fertility (ovariole number)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Green DA; Extavour CG (2012) Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...] 1 Additional References Bergland AO; Genissel A; Nuzhdin SV (2008) Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole [...]	GP00000132	bab2 Q9W0K4	Physiology	unknown ; loss of function reduces ovariole number	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		bab2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
BAK1	Hematopoiesis (blood platelet count)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001616	BAK1 Q16611	Physiology	A>G at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		BAK1	Homo sapiens human - (species)	Published - Accepted by Curator
BarH1	Coloration (wing; sex-specific; female-specific)	Cis-regulatory, Insertion	Colias croceus clouded yellow - (species) D	Intraspecific	Association Mapping	Woronik A; Tunström K; Perry MW ; et al. (2019) A transposable element insertion is associated with an alternative life history strategy.	GP00002095	B-H1 Q24255	Morphology	insertion of a Jockey-like transposable element 6 kb downstream of the Colias homolog of BarH-1. BarH-1 expression suppresses orange coloration in the wings.	Colias croceus clouded yellow - (species)	Colias croceus clouded yellow - (species) D		BarH1	Colias croceus clouded yellow - (species)	Published - Accepted by Curator
BCMA	Glucosinolate content Herbivore resistance	3 Mutations:	Boechera stricta (species)	Intraspecific	Linkage Mapping	Prasad KV; Song BH; Olson-Manning C ; et al. (2012) A gain-of-function polymorphism controlling complex traits and fitness in nature.	GP00000136	J9QWI9	Physiology Physiology	3 mutations	Boechera stricta (species)	Boechera stricta (species)		BCMA	Boechera stricta (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Coloration (ventral scales)	Cis-regulatory, Unknown	Podarcis muralis Common wall lizard - (species)	Intraspecific	Association Mapping	Andrade P; Pinho C; Pérez I de Lanuza G ; et al. (2019) Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall [...]	GP00002120	Bco2 Q99NF1	Morphology		Podarcis muralis Common wall lizard - (species)	Podarcis muralis Common wall lizard - (species)		BCO2 = beta-carotene oxygenase 2	Podarcis muralis Common wall lizard - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Coloration (beak)	Cis-regulatory, Unknown	Geospiza scandens (species) D Geospiza fortis medium ground-finch - (species) D Geospiza conirostris (species) D Geospiza magnirostris (species) D Geospiza fuliginosa (species) D Camarhynchus parvulus (species) D Camarhynchus pauper (species) D Camarhynchus pallidus woodpecker finch - (species) D Geospiza difficilis (species) D	Intraspecific	Association Mapping	Enbody ED; Sprehn CG; Abzhanov A ; et al. (2021) A multispecies BCO2 beak color polymorphism in the Darwin's finch radiation.	GP00002384	BCO2 Q9BYV7	Morphology	"By closely inspecting this region in a combined sample of all 456 finches of the two species we identified a single exonic SNP with a likelihood ratio test (LRT) statistic exceeding 166 (Figure 1C). It is also the only consistently elevated SNP in an analysis of each species alone (Figure S1), is the best fit variant under a recessive model (STAR Methods), and occurs on multiple haplotypes (Figure S1C). This SNP (chr24:6,166,878; p6166878 hereafter) leads to a synonymous change 32 bp into exon 4 of BCO2. " "The functional importance of the observed synonymous change is uncertain, and the presence of an unidentified linked causal variant cannot be completely ruled out (see Conclusions). However, a functional explanation is possible because codon usage can be under strong selection30 and may have functional consequences on translation,30 RNA stability,31 and transcription.32 Notably, p6166878 changes the highest frequency valine codon (ƒGTG = 27.3%) to the lowest (ƒGTA = 7.6%) in the reference genome. This is in line with the observed phenotypic effect of the yellow mutation because a lower abundance codon is expected to be associated with lower protein expression.33 In this case, less BCO2 activity results in more carotenoid deposition in the yellow morph. In fact, we found that yellow homozygotes showed significantly lower BCO2 expression compared to pink homozygotes in the upper beak of developing embryos (Figure 1F) that were sourced from a variety of different species and islands (Table S1): small sample sizes prohibit species-specific analysis. Among the six heterozygous individuals, the pink allele was expressed more than the yellow allele in five samples tested using a droplet-digital PCR (Figure S2C). Differences in expression between the two alleles, and in the absence of alternative splice variants (STAR Methods), raise the possibility that the synonymous change alters transcription factor binding affinity in exon 4. Further research into tissue-specific expression and the specific transcription factors that regulate BCO2 is warranted."	Geospiza scandens (species) Geospiza fortis medium ground-finch - (species) Geospiza conirostris (species) Geospiza magnirostris (species) Geospiza fuliginosa (species) Camarhynchus parvulus (species) Camarhynchus pauper (species) Camarhynchus pallidus woodpecker finch - (species) Geospiza difficilis (species)	Geospiza scandens (species) D Geospiza fortis medium ground-finch - (species) D Geospiza conirostris (species) D Geospiza magnirostris (species) D Geospiza fuliginosa (species) D Camarhynchus parvulus (species) D Camarhynchus pauper (species) D Camarhynchus pallidus woodpecker finch - (species) D Geospiza difficilis (species) D		BCO2 = beta-carotene oxygenase 2	Geospiza scandens (species) Geospiza fortis medium ground-finch - (species) Geospiza conirostris (species) Geospiza magnirostris (species) Geospiza fuliginosa (species) Camarhynchus parvulus (species) Camarhynchus pauper (species) Camarhynchus pallidus woodpecker finch - (species) Geospiza difficilis (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001263	BGLU6 Q682B4	Physiology	T-> A of a splice site at position 168 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001264	BGLU6 Q682B4	Physiology	1-bp deletion of a splice site at position 395 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001265	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 913 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001266	BGLU6 Q682B4	Physiology	A deletion of one nucleotide in the seventh exon (BGLU6 CDS position 678) results in a premature stop codon in the accessions Bor-4, Se-0, Uod-1, and Zdr-1. premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001267	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 1138 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Kwa MS; Veenstra JG; Roos MH (1994) Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001785	TUB2 P02557	Physiology	Phe200Tyr	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D		beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Trichostrongylus colubriformis (species) D	Intraspecific	Candidate Gene	Kwa MS; Veenstra JG; Roos MH (1994) Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001786	TUB2 P02557	Physiology	Phe200Tyr	Trichostrongylus colubriformis (species)	Trichostrongylus colubriformis (species) D		beta-tubulin	Trichostrongylus colubriformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001788	TUB2 P02557	Physiology	Phe200Tyr	Venturia inaequalis (species)	Venturia inaequalis (species) D		beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001789	TUB2 P02557	Physiology	Phe200Tyr		D		beta-tubulin		Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium italicum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001790	TUB2 P02557	Physiology	Phe200Tyr	Penicillium italicum (species)	Penicillium italicum (species) D		beta-tubulin	Penicillium italicum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium aurantiogriseum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001791	TUB2 P02557	Physiology	Phe200Tyr	Penicillium aurantiogriseum (species)	Penicillium aurantiogriseum (species) D		beta-tubulin	Penicillium aurantiogriseum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium aurantiogriseum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001792	TUB2 P02557	Physiology	Glu198Lys	Penicillium aurantiogriseum (species)	Penicillium aurantiogriseum (species) D		beta-tubulin	Penicillium aurantiogriseum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium viridicatum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001793	TUB2 P02557	Physiology	Glu198Lys	Penicillium viridicatum (species)	Penicillium viridicatum (species) D		beta-tubulin	Penicillium viridicatum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Clarireedia homoeocarpa (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001794	TUB2 P02557	Physiology	Glu1198Lys	Clarireedia homoeocarpa (species)	Clarireedia homoeocarpa (species) D		beta-tubulin	Clarireedia homoeocarpa (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001795	TUB2 P02557	Physiology	Glu1198Lys	Venturia inaequalis (species)	Venturia inaequalis (species) D		beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001796	TUB2 P02557	Physiology	Glu1198Ala	Venturia inaequalis (species)	Venturia inaequalis (species) D		beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001797	TUB2 P02557	Physiology	Glu1198Ala		D		beta-tubulin		Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Monilinia fructicola (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001798	TUB2 P02557	Physiology	Glu1198Lys	Monilinia fructicola (species)	Monilinia fructicola (species) D		beta-tubulin	Monilinia fructicola (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium puberulum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001799	TUB2 P02557	Physiology	Glu1198Lys	Penicillium puberulum (species)	Penicillium puberulum (species) D		beta-tubulin	Penicillium puberulum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium puberulum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001800	TUB2 P02557	Physiology	Glu1198Ala	Penicillium puberulum (species)	Penicillium puberulum (species) D		beta-tubulin	Penicillium puberulum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium digitatum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001801	TUB2 P02557	Physiology	Glu1198Lys	Penicillium digitatum (species)	Penicillium digitatum (species) D		beta-tubulin	Penicillium digitatum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium expansum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001802	TUB2 P02557	Physiology	Glu1198Ala	Penicillium expansum (species)	Penicillium expansum (species) D		beta-tubulin	Penicillium expansum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium italicum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001803	TUB2 P02557	Physiology	Glu198Lys	Penicillium italicum (species)	Penicillium italicum (species) D		beta-tubulin	Penicillium italicum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Teladorsagia circumcincta (species) D	Intraspecific	Candidate Gene	Elard L; Humbert JF (1999) Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole[...]	GP00001815	TUB2 P02557	Physiology	Phe200Tyr	Teladorsagia circumcincta (species)	Teladorsagia circumcincta (species) D		beta-tubulin	Teladorsagia circumcincta (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Prichard R; Oxberry M; Bounhas Y ; et al. (2000 ) Polymerisation and benzimidazole binding assays with recombinant α-and β-tubulins from Haemonchus co[...] 2 Additional References Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...] Li J; Katiyar SK; Edlind TD (1996) Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 [...]	GP00001816	TUB2 P02557	Physiology	Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus b-tubulin (produced in a prokaryote system)	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D		beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Cyathostoma (genus) D	Intraspecific	Candidate Gene	Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...] 1 Additional References Li J; Katiyar SK; Edlind TD (1996) Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 [...]	GP00001817	TUB2 P02557	Physiology	Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus and S. cerevisiae b-tubulin (produced in a prokaryote system)	Cyathostoma (genus)	Cyathostoma (genus) D		beta-tubulin	Cyathostoma (genus)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Neurospora crassa (species) D	Intraspecific	Candidate Gene	Orbach MJ; Porro EB; Yanofsky C (1986) Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurosp[...]	GP00001818	TUB2 P02557	Physiology	Phe167Tyr	Neurospora crassa (species)	Neurospora crassa (species) D		beta-tubulin	Neurospora crassa (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Teladorsagia circumcincta (species) D	Intraspecific	Candidate Gene	Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]	GP00001819	TUB2 P02557	Physiology	Phe167Tyr	Teladorsagia circumcincta (species)	Teladorsagia circumcincta (species) D		beta-tubulin	Teladorsagia circumcincta (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Ghisi M; Kaminsky R; Mäser P (2007) Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutatio[...]	GP00001820	TUB2 P02557	Physiology	Glu198Ala	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D		beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]	GP00001821	TUB2 P02557	Physiology	Phe200Tyr	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]	GP00001822	TUB2 P02557	Physiology	Phe200Tyr	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001823	TUB2 P02557	Physiology	E198A	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001824	TUB2 P02557	Physiology	E198G	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001825	TUB2 P02557	Physiology	E198K	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001826	TUB2 P02557	Physiology	E198A	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001827	TUB2 P02557	Physiology	E198G	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001828	TUB2 P02557	Physiology	E198Q	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001829	TUB2 P02557	Physiology	L240F	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001830	TUB2 P02557	Physiology	A185P - missense_variant_c.553G>C_3539974 – A185P N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001832	TUB2 P02557	Physiology	stop_gained_HIGH_c.1267C>T_3538394 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001833	TUB2 P02557	Physiology	Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001834	TUB2 P02557	Physiology	missense_variant_MODERATE_c.1210G>A_3538451 – D404N N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001835	TUB2 P02557	Physiology	Del_3539006_3539808 – 802bp deletion of coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001836	TUB2 P02557	Physiology	stop_gained_HIGH_c.1135A>T_3539335 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001837	TUB2 P02557	Physiology	stop_gained_HIGH_c.1112C>A_3539358 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001838	TUB2 P02557	Physiology	Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001839	TUB2 P02557	Physiology	Del_3539470_3539471 – 1bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001840	TUB2 P02557	Physiology	Del_3539507_3539514 – 7bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001841	TUB2 P02557	Physiology	Del_3539559_3539745 – 186 bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001842	TUB2 P02557	Physiology	Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001843	TUB2 P02557	Physiology	missense_variant_MODERATE_c.771G>A_3539699 – M257I N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001844	TUB2 P02557	Physiology	Del_3539746_3539908 – 162 bp deletion in exon3-4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001845	TUB2 P02557	Physiology	stop_gained_HIGH_c.549C>A_3539978 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001846	TUB2 P02557	Physiology	missense_variant_MODERATE_c.434C>T_3540145 – S145F N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001847	TUB2 P02557	Physiology	missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001848	TUB2 P02557	Physiology	Del_3540300_3540301 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Inversion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001849	TUB2 P02557	Physiology	Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Unknown N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001850	TUB2 P02557	Physiology	Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001851	TUB2 P02557	Physiology	Del_3540407_3540408 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001852	TUB2 P02557	Physiology	Del_3540970_3544000 – 3030bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001853	TUB2 P02557	Physiology	Del_3541317_3541856 – 539 bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001854	TUB2 P02557	Physiology	splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001855	TUB2 P02557	Physiology	stop_gained_HIGH_c.153T>G_3541441 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001856	TUB2 P02557	Physiology	Del_3541499_3541502 – 3bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001857	TUB2 P02557	Physiology	Ins_3541547_3541548 – 1 bp insertion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben4)	Xenobiotic resistance (benzimidazole)	Coding, SNP	Aspergillus nidulans (species) D	Intraspecific	Candidate Gene	Jung MK; Wilder IB; Oakley BR (1992) Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl r[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001787	TUB2 P02557	Physiology	Phe200Tyr	Aspergillus nidulans (species)	Aspergillus nidulans (species) D		beta-tubulin (ben4)	Aspergillus nidulans (species)	Published - Accepted by Curator
BHLHE41	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Huerta-Sánchez E; Degiorgio M; Pagani L ; et al. (2013) Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.	GP00000144	BHLHE41 Q9C0J9	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		BHLHE41	Homo sapiens human - (species)	Published - Accepted by Curator
BMP6	Tooth number	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Cleves PA; Ellis NA; Jimenez MT ; et al. (2014) Evolved tooth gain in sticklebacks is associated with a cis-regulatory allele of Bmp6. 2 Additional References Ellis NA; Glazer AM; Donde NN (2015) Distinct developmental genetic mechanisms underlie convergently evolved tooth gain in sticklebacks. Erickson PA; Cleves PA; Ellis NA (2015) A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression[...]	GP00000154	Bmp6 P20722	Morphology	Candidate enhancer of 190bp recapitulating tooth and fin expression of BMP6	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		BMP6	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Brassinosteroid-deficient dwarf1 (brd1)	Plant size (height)	Unknown, Unknown	Zea mays (species)	Intraspecific	Linkage Mapping	Peiffer JA; Romay MC; Gore MA ; et al. (2014) The genetic architecture of maize height.	GP00001628	ZEAMMB73_Zm00001d033180 A0A1D6KWT1	Morphology	On chromosome 1 two C>T transitions reduce plant height in 18RIL families	Zea mays (species)	Zea mays (species)		Brassinosteroid-deficient dwarf1 (brd1)	Zea mays (species)	Published - Accepted by Curator
Brevis radix (BRX)	Root size (shorter)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Mouchel CF; Briggs GC; Hardtke CS (2004) Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell prolifer[...]	GP00000157	BRX Q17TI5	Morphology	premature stop codon in exon 4; TGG>TGA; truncated protein missing approximately two-thirds of the C terminus N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Brevis radix (BRX)	pH tolerance (acidic soil)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gujas B; Alonso-Blanco C; Hardtke CS (2012) Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil.	GP00001236	BRX Q17TI5	Physiology	K188* (stop codon) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Brevis radix (BRX)	Root growth	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Beuchat J; Li S; Ragni L ; et al. (2010) A hyperactive quantitative trait locus allele of Arabidopsis BRX contributes to natural variation in[...]	GP00001262	BRX Q17TI5	Morphology	21bp deletion at position in spacer 3 (position not given)	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
BvCPSF73-Ia	Bolting time	Coding, Deletion N	Beta vulgaris (species) D	Intraspecific	Linkage Mapping	Tränkner C; Lemnian IM; Emrani N ; et al. (2016) A Detailed Analysis of the BR Locus Suggests a New Mechanism for Bolting after Winter in Sugar Beet [...]	GP00001411	CPSF73-I Q9C952	Physiology	2bp deletion causing a frameshift resulting in a two third truncated protein N	Beta vulgaris (species)	Beta vulgaris (species) D		BvCPSF73-Ia	Beta vulgaris (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, Unknown N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]	GP00000160	BtR Q19KJ3	Physiology	premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		cadherin	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		cadherin	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000164	BtR Q19KJ3	Physiology	24bp in-frame deletion	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, SNP N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Walsh T; James B; Chakroun M ; et al. (2018) Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]	GP00002055	BtR Q19KJ3	Physiology	splice site GT mutated in GA so that splicing does not occur correctly and a 58 bp insertion is found in the cDNA sequence of the cadherin gene. This insertion disrupts the coding sequence in cadherin domain 9 causing a downstream frameshift and a premature stop codon for the rest of the protein. This would result in a truncated protein of 1243 amino acids without the putative binding domain; the membrane anchoring domain; presumably retained inside the cell and not exposed to the Cry1Ac; or alternatively; exported into the gut where it would be degraded N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D		cadherin	Helicoverpa punctigera (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion	Ostrinia furnacalis Asian corn borer - (species) D	Intraspecific	Candidate Gene	Jin T; Chang X; Gatehouse AM ; et al. (2014) Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...] 1 Additional References Jurat-Fuentes JL; Heckel DG; Ferré J (2021) Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis.	GP00002464	A0A1B0RHM4	Physiology	MPR-r2 has a 26-amino acid residue deletion in the TBR which results in reduced binding of Cry1Ac compared to the MPR from the susceptible strain.	Ostrinia furnacalis Asian corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species) D		cadherin	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP	Ostrinia furnacalis Asian corn borer - (species) D	Intraspecific	Candidate Gene	Jin T; Chang X; Gatehouse AM ; et al. (2014) Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...] 1 Additional References Jurat-Fuentes JL; Heckel DG; Ferré J (2021) Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis.	GP00002465	A0A1B0RHM4	Physiology	Thr1457Ser	Ostrinia furnacalis Asian corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species) D		cadherin	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
calmodulin binding hydrolase	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001438	Q9FHQ0	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		calmodulin binding hydrolase	Arabidopsis arenosa (species)	Published - Accepted by Curator
Camta3	Plant size (height)	Unknown, Unknown	Zea mays (species)	Intraspecific	Association Mapping	Peiffer JA; Romay MC; Gore MA ; et al. (2014) The genetic architecture of maize height.	GP00001629	CAMTA3 Q8GSA7	Morphology	C>T transition on chromosome 3	Zea mays (species)	Zea mays (species)		Camta3	Zea mays (species)	Published - Accepted by Curator
Casparian strip membrane domain protein 1	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001432	CASP1 Q9SIH4	Physiology	five aa sustitutions	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		Casparian strip membrane domain protein 1	Arabidopsis arenosa (species)	Published - Accepted by Curator
catechol-O-methyltransferase (COMT)	Pain sensitivity	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Nackley AG; Shabalina SA; Tchivileva IE ; et al. (2006) Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary[...]	GP00000171	COMT P21964	Behavior	G/C - The synonymous mutation(s) affect mRNA stability and loop structures	Homo sapiens human - (species)	Homo sapiens human - (species)		catechol-O-methyltransferase (COMT)	Homo sapiens human - (species)	Published - Accepted by Curator
Catecholamines up	Bristle number Lifespan Locomotor activity Sleep	Coding, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Carbone MA; Jordan KW; Lyman RF ; et al. (2006) Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Droso[...] 1 Additional References Stein MB; Koverola C; Hanna C (1997) Hippocampal volume in women victimized by childhood sexual abuse.	GP00000172	Catsup Q9V3A4	Morphology Physiology Behavior Behavior	unknown; but most large-effect variants appear to be coding	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Catecholamines up	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CBF gene cluster	Temperature tolerance (cold)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Gery C; Zuther E; Schulz E ; et al. (2011) Natural variation in the freezing tolerance of Arabidopsis thaliana: effects of RNAi-induced CBF dep[...]	GP00000174	B1NSN2	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		CBF gene cluster	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CCAAT-enhancer-binding protein alpha (CEBPA)	Hematopoiesis (blood basophil count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001603	CEBPA P49715	Physiology	C>T at the associated SNP which resides 39kb dowstream from CEBPA near a separate enhancer that influences CEBPA expression along various myeloid lineages. T allele was associated with a 28.6% reduction in enhancer activity.	Homo sapiens human - (species)	Homo sapiens human - (species)		CCAAT-enhancer-binding protein alpha (CEBPA)	Homo sapiens human - (species)	Published - Accepted by Curator
ccdc170	Coloration	Unknown, Unknown	Anolis sagrei Brown anole - (species)	Intraspecific	Association Mapping	Feiner N; Brun-Usan M; Andrade P ; et al. (2022) A single locus regulates a female-limited color pattern polymorphism in a reptile.	GP00002363	Ccdc170 D3YXL0	Morphology		Anolis sagrei Brown anole - (species)	Anolis sagrei Brown anole - (species)		ccdc170	Anolis sagrei Brown anole - (species)	Published - Accepted by Curator
CCL3L1	Pathogen resistance (HIV)	Gene Amplification, Indel	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Gonzalez E; Kulkarni H; Bolivar H ; et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.	GP00000177	CCL3L1 P16619	Physiology	Copy number Variant	Homo sapiens human - (species)	Homo sapiens human - (species) D		CCL3L1	Homo sapiens human - (species)	Published - Accepted by Curator
CG11699	Xenobiotic resistance	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	Mateo L; Ullastres A; González J (2014) A transposable element insertion confers xenobiotic resistance in Drosophila.	GP00001399	Dmel\CG11699 Q9VYX5	Physiology	insertion of a 186bp POGON1 element in the 3'UTR	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		CG11699	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Chalcone synthase D (CHS-D)	Coloration (flower)	Unknown, Insertion	Ipomoea purpurea common morning-glory - (species) D	Intraspecific	Candidate Gene	Habu Y; Hisatomi Y; Iida S (1998) Molecular characterization of the mutable flaked allele for flower variegation in the common morning[...]	GP00001459	CHSD O22045	Morphology	insertion of a 3.9kb long transposable element Tip100 in intron	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		Chalcone synthase D (CHS-D)	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
Chalcone synthase D (CHS-D)	Coloration (flower)	Unknown, Insertion	Ipomoea purpurea common morning-glory - (species) D	Intraspecific	Candidate Gene	Habu Y; Hisatomi Y; Iida S (1998) Molecular characterization of the mutable flaked allele for flower variegation in the common morning[...]	GP00001460	CHSD O22045	Morphology	2 insertions of Tip100 in opposite orientation at different sites within the same intron	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		Chalcone synthase D (CHS-D)	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
Chalk5	Grain chalkiness Amylose content Grain yield	Cis-regulatory, SNP	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Li Y; Fan C; Xing Y ; et al. (2014) Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase influencing grain chalkiness in rice.	GP00001309	Chalk5 A2Y0L3	Morphology Physiology Physiology	Two candidate SNPs at positions -721 and - 485 in promoter region	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Chalk5	Oryza sativa rice - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide ; benzoylurea)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Douris V; Steinbach D; Panteleri R ; et al. (2016) Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]	GP00001600	CHS1 A3KCN0	Physiology	T>G p.I1042M (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		Chitin synthase 1 (CHS1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; benzoylurea)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Douris V; Steinbach D; Panteleri R ; et al. (2016) Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]	GP00001601	CHS1 A3KCN0	Physiology	A>T p.I1042F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		Chitin synthase 1 (CHS1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; etoxazole acaricide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species)	Intraspecific	Linkage Mapping	Demaeght P; Osborne EJ; Odman-Naresh J ; et al. (2014) High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally di[...] 1 Additional References Van Leeuwen T; Demaeght P; Osborne EJ (2012) Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin s[...]	GP00001602	chs1 H9U0G2	Physiology	A>T p.I1017F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species)		Chitin synthase 1 (CHS1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; benzoylurea)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Suzuki Y; Shiotsuki T; Jouraku A ; et al. (2017) Benzoylurea resistance in western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae)[...]	GP00002628	CHS1 A3KCN0	Physiology	isoleucine to methionine	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		Chitin synthase 1 (CHS1)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
CHKov1	Pathogen resistance Xenobiotic resistance (insecticide)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Magwire MM; Bayer F; Webster CL ; et al. (2011) Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...] 1 Additional References Aminetzach YT; Macpherson JM; Petrov DA (2005) Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila.	GP00000182	CHKov1 Q961V7	Physiology Physiology	Insertion of a Doc TE element resulting in novel; seemingly functional short protein	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		CHKov1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
chloroquine resistance transporter	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001533	CRT Q9N623	Physiology	p.Ile356Thr	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		chloroquine resistance transporter	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
CHRNA3/5 nicotine receptor cluster	Aging Smoking behavior	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000185	CHRNA3 P32297	Physiology Physiology	unknown; complex variation with SNP association signal	Homo sapiens human - (species)	Homo sapiens human - (species)		CHRNA3/5 nicotine receptor cluster	Homo sapiens human - (species)	Published - Accepted by Curator
CLH1	Xenobiotic resistance (fungicide: guazatine)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Atanasov KE; Barboza-Barquero L; Tiburcio AF ; et al. (2016) Genome Wide Association Mapping for the Tolerance to the Polyamine Oxidase Inhibitor Guazatine in Ar[...]	GP00001234	CLH1 O22527	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		CLH1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 1 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.	GP00002163	Cmah Q61419	Physiology	c.179G>T p.G60V	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 1 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.	GP00002164	Cmah Q61419	Physiology	c.364C>T p.P122S	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, Deletion N	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Kehl A; Heimberger K; Langbein-Detsch I (2018) Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping sch[...]	GP00002165	Cmah Q61419	Physiology	c.1322delT p.Leu441* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002166	Cmah Q61419	Physiology	c.139G>A p.V47M	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002167	Cmah Q61419	Physiology	c.268T>A p.Y89N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002168	Cmah Q61419	Physiology	c.1600G>A p.D534N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CORIN	Coloration (coat)	Coding, SNP	Panthera tigris tiger - (species) D	Intraspecific	Linkage Mapping	Xu X; Dong GX; Schmidt-Küntzel A ; et al. (2017) The genetics of tiger pelage color variations.	GP00002169	Corin Q9Z319	Morphology	c.1759C >T p.H587Y	Panthera tigris tiger - (species)	Panthera tigris tiger - (species) D		CORIN	Panthera tigris tiger - (species)	Published - Accepted by Curator
cortex	Coloration (wing ; industrial melanism ; camouflage)	Cis-regulatory, Insertion	Biston betularia pepper-and-salt moth - (species) D	Intraspecific	Linkage Mapping	Van't Hof AE; Campagne P; Rigden DJ ; et al. (2016) The industrial melanism mutation in British peppered moths is a transposable element.	GP00001804	cort Q960N3	Morphology	Putative transposon insertion within the first intron ; consists of of ~9 kb tandemly repeated 2.3 times + three short tandem subrepeat units	Biston betularia pepper-and-salt moth - (species)	Biston betularia pepper-and-salt moth - (species) D		cortex	Biston betularia pepper-and-salt moth - (species)	Published - Accepted by Curator
cortex	Coloration (wing ; leaf mimicry ; camouflage)	Cis-regulatory, Complex Change	Kallima inachus orange oakleaf - (species) D	Intraspecific	Association Mapping	Wang S; Teng D; Li X ; et al. (2022) The evolution and diversification of oakleaf butterflies.	GP00002413	cort Q960N3	Morphology		Kallima inachus orange oakleaf - (species)	Kallima inachus orange oakleaf - (species) D		cortex	Kallima inachus orange oakleaf - (species)	Published - Accepted by Curator
cortex	Coloration (wing ; leaf mimicry ; camouflage)	Cis-regulatory, Unknown	Kallima inachus orange oakleaf - (species) D	Intraspecific	Association Mapping	Wang S; Teng D; Li X ; et al. (2022) The evolution and diversification of oakleaf butterflies.	GP00002414	cort Q960N3	Morphology		Kallima inachus orange oakleaf - (species)	Kallima inachus orange oakleaf - (species) D		cortex	Kallima inachus orange oakleaf - (species)	Published - Accepted by Curator
cortex	Coloration (wing ; leaf mimicry ; camouflage)	Cis-regulatory, Unknown	Kallima inachus orange oakleaf - (species) D	Intraspecific	Association Mapping	Wang S; Teng D; Li X ; et al. (2022) The evolution and diversification of oakleaf butterflies.	GP00002415	cort Q960N3	Morphology		Kallima inachus orange oakleaf - (species)	Kallima inachus orange oakleaf - (species) D		cortex	Kallima inachus orange oakleaf - (species)	Published - Accepted by Curator
cortex	Coloration (wing ; leaf mimicry ; camouflage)	Cis-regulatory, Unknown	Kallima inachus orange oakleaf - (species) D	Intraspecific	Association Mapping	Wang S; Teng D; Li X ; et al. (2022) The evolution and diversification of oakleaf butterflies.	GP00002416	cort Q960N3	Morphology	Large inversion and many mutations in the large inverted region.	Kallima inachus orange oakleaf - (species)	Kallima inachus orange oakleaf - (species) D		cortex	Kallima inachus orange oakleaf - (species)	Published - Accepted by Curator
cortex	Coloration (wing; mimicry)	Unknown, Unknown	Papilio clytia common mime swallowtail - (species)	Intraspecific	Association Mapping	VanKuren NW; Massardo D; Nallu S ; et al. (2019) Butterfly Mimicry Polymorphisms Highlight Phylogenetic Limits of Gene Reuse in the Evolution of Dive[...]	GP00002419	cort Q960N3	Morphology	Mapping to a 500-kb region that contains the cortex gene	Papilio clytia common mime swallowtail - (species)	Papilio clytia common mime swallowtail - (species)		cortex	Papilio clytia common mime swallowtail - (species)	Published - Accepted by Curator
cortex	Coloration (wing)	Cis-regulatory, Insertion	Heliconius melpomene postman butterfly - (species) D	Intraspecific	Association Mapping	Livraghi L; Hanly JJ; Van Bellghem SM ; et al. (2021) Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius.	GP00002660	cort Q960N3	Morphology	Insertion of two transposable elements (BovB-like and Helitron-like)	Heliconius melpomene postman butterfly - (species)	Heliconius melpomene postman butterfly - (species) D		cortex	Heliconius melpomene postman butterfly - (species)	Published - Accepted by Curator
Couch potato	Diapause	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Schmidt PS; Zhu CT; Das J ; et al. (2008) An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]	GP00000191	cpo Q01617	Physiology	Ile462Lys	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Couch potato	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, SNP N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002102	Q95WY5	Physiology	Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin. N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Insertion N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002103	Q95WY5	Physiology	Insertion of a 451-bpTE into the exon 2 of the toxin receptor gene. The insertion induces a new mRNA splicing event that creates a shorter transcript. This new transcript encodes an altered receptor unable to interact with the toxin resulting in resistance to this insecticide. The missing portion includes GPI-anchoring signals N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Deletion N	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Guo QY; Cai QX; Yan JP ; et al. (2013) Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaeri[...] 1 Additional References Darboux I; Pauchet Y; Castella C (2002) Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.	GP00002552	Q95WY5	Physiology	one-nucleotide deletion which results in a premature stop codon and leads to production of a truncated protein. N	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		Cpm1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
CPR	Xenobiotic resistance	Gene Amplification, Insertion	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Linkage Mapping	Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021) High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]	GP00002398	Cpr Q27597	Physiology	Pyflubumide resistant populations are estimated to harbor three CPR copies by two methods, whereas susceptible populations have a single CPR copy.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		CPR	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CREBRF	Body size (obesity)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Minster RL; Hawley NL; Su CT ; et al. (2016) A thrifty variant in CREBRF strongly influences body mass index in Samoans.	GP00001444	CREBRF Q8IUR6	Morphology	c.1370G>A p.Arg457Gln	Homo sapiens human - (species)	Homo sapiens human - (species) D		CREBRF	Homo sapiens human - (species)	Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele	Flowering time Fruit shape (fruit length) Flower morphology (ovule number per fruit) Fertility (percentage of unfertilized ovules)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001) A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2. 3 Additional References Olsen KM; Halldorsdottir SS; Stinchcombe JR (2004) Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. el-Assal SE; Alonso-Blanco C; Hanhart CJ (2004) Pleiotropic effects of the Arabidopsis cryptochrome 2 allelic variation underlie fruit trait-related[...] Botto JF; Alonso-Blanco C; Garzarón I (2003) The Cape Verde Islands allele of cryptochrome 2 enhances cotyledon unfolding in the absence of blue [...]	GP00000192	CRY2 Q96524	Physiology Morphology Morphology Physiology	V367M	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Cryptochrome 2 (CRY2) EDI allele	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CXCL16	Pathogen resistance (lymphocyte susceptibility to virus)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Association Mapping	Sarkar S; Bailey E; Go YY ; et al. (2016) Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus In[...]	GP00001591	CXCL16 F7CTX0	Physiology	4 candidate nonsynonymous substitutions within exon 1(in 2 susceptible variants): (1)c.715A>T p.Tyr40Phe (2)c.801G>C w.Asp49His (3)c.804T>A/G p.Phe50Ile (4)c.810G>A p.Glu52Lys	Equus caballus horse - (species)	Equus caballus horse - (species)		CXCL16	Equus caballus horse - (species)	Published - Accepted by Curator
CYC-like HaCYC2c	Flower morphology	Cis-regulatory, Insertion	Helianthus annuus common sunflower - (species) D	Intraspecific	Linkage Mapping	Chapman MA; Tang S; Draeger D ; et al. (2012) Genetic analysis of floral symmetry in Van Gogh's sunflowers reveals independent recruitment of CYCL[...]	GP00000193	CYC O49250	Morphology	999bp insertion in promoter	Helianthus annuus common sunflower - (species)	Helianthus annuus common sunflower - (species) D		CYC-like HaCYC2c	Helianthus annuus common sunflower - (species)	Published - Accepted by Curator
CYC-like RAY1/RAY2	Flower morphology	Gene Amplification, Complex Change	Senecio vulgaris (species)	Intraspecific	Linkage Mapping	Kim M; Cui ML; Cubas P ; et al. (2008) Regulatory genes control a key morphological and ecological trait transferred between species.	GP00000194	CYC O49250	Morphology	Gene gain by hybridization	Senecio vulgaris (species)	Senecio vulgaris (species)		CYC-like RAY1/RAY2	Senecio vulgaris (species)	Published - Accepted by Curator
CYCD5;1	Endoreduplication	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sterken R; Kiekens R; Boruc J ; et al. (2012) Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoredupl[...]	GP00000196	CYCD5-1 Q2V3B2	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		CYCD5;1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Cycloidea (Lcyc)	Flower morphology	Cis-regulatory, Epigenetic Change	Linaria vulgaris common toadflax - (species) D	Intraspecific	Linkage Mapping	Cubas P; Vincent C; Coen E (1999) An epigenetic mutation responsible for natural variation in floral symmetry.	GP00000197	CYC O49250	Morphology	Stable methylation	Linaria vulgaris common toadflax - (species)	Linaria vulgaris common toadflax - (species) D		Cycloidea (Lcyc)	Linaria vulgaris common toadflax - (species)	Published - Accepted by Curator
CYP(T)	Flower morphology (style length)	Coding, Insertion N	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001394	CYP734A1 O48786	Morphology	single base insertion in exon 2 introduces a disruptive premature stop codon N	Primula vulgaris (species)	Primula vulgaris (species) D		CYP(T)	Primula vulgaris (species)	Published - Accepted by Curator
CYP(T)	Flower morphology (style length)	Coding, SNP	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001395	CYP734A1 O48786	Morphology	G>C p.Asp126His in exon 2	Primula vulgaris (species)	Primula vulgaris (species) D		CYP(T)	Primula vulgaris (species)	Published - Accepted by Curator
Cyp12d1	Xenobiotic resistance (caffeine tolerance)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Najarro MA; Hackett JL; Smith BR ; et al. (2015) Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.	GP00000198	Cyp12d1-d Q7KR10	Physiology	Copy number Variant	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Cyp12d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP1A2	Enzymatic activity	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Murayama N; Soyama A; Saito Y ; et al. (2004) Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]	GP00000199	CYP1A2 P05177	Physiology	F186L	Homo sapiens human - (species)	Homo sapiens human - (species) D		CYP1A2	Homo sapiens human - (species)	Published - Accepted by Curator
Cyp28d1	Xenobiotic resistance (nicotine ; larval stage)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chakraborty M; VanKuren NW; Zhao R ; et al. (2018) Hidden genetic variation shapes the structure of functional elements in Drosophila. 2 Additional References Marriage TN; King EG; Long AD (2014) Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cr[...] Chakraborty M; Emerson JJ; Macdonald SJ (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00001407	Cyp28d1 Q9VMT5	Physiology	insertion of a partial 1.5kb Accord transposable element and a Cyp28d1 gene tandem duplication (CNV - 3754 bp) that may play complementary role in resistance levels	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Cyp28d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cyp28d1	Xenobiotic resistance (nicotine ; larval stage)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002113	Cyp28d1 Q9VMT5	Physiology	insertion of a FW element (4720 bp) into the coding region (exon) of the second copy of the Cyp28d1 (there is still another copy of the gene left due to a duplication). Associated with a decrease in Cyp28d2 gene expression and a decrease in nicotin resistance.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Cyp28d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cyp28d1-Cyp28d2	Xenobiotic resistance (nicotine ; larval stage)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002112	Cyp28d1 Q9VMT5	Physiology	duplication of 6063 bp which includes genes Cyp28d1; Cyp28d2 and CG7742. Associated with increased expression of Cyp28d2 and increased resistance to nicotin	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Cyp28d1-Cyp28d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cyp28d1-Cyp28d2	Xenobiotic resistance (nicotine ; larval stage)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002114	Cyp28d1 Q9VMT5	Physiology	duplication of a 15297-bp region; which encompasses 5 genes: Msp300 Cyp28d2 Cyp28d1 CG7742 and CG14034. Associated with increased expression of Cyp28d1 gene expression and increased nicotin resistance	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Cyp28d1-Cyp28d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP2C9	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000200	CYP2C9 P11712	Physiology	I359L	Homo sapiens human - (species)	Homo sapiens human - (species)		CYP2C9	Homo sapiens human - (species)	Published - Accepted by Curator
CYP321A8	Xenobiotic resistance (organophosphate; chlorpyrifos; pyrethroid; cypermethrin; deltamethrin)	Cis-regulatory, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Candidate Gene	Hu B; Huang H; Hu S ; et al. (2021) Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron [...]	GP00002394	CYP321A8 A0A286QUG5	Physiology	A > G at position -197bp in a cis-regulatory region, leading to increased expression of the gene	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		CYP321A8	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Association Mapping	Joußen N; Agnolet S; Lorenz S ; et al. (2012) Resistance of Australian Helicoverpa armigera to fenvalerate is due to the chimeric P450 enzyme CYP3[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002477	CYP337B3 A0A0H3V333	Physiology	The unique P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The exclusive presence of CYP337B3 in resistant insects of this strain confers a 42-fold resistance to fenvalerate.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Rasool Akhtar; Joußen Nicole; Lorenz Sybille ; et al. (2014 ) An independent occurrence of the chimeric P450 enzyme CYP337B3 of Helicoverpa armigera confers cyper[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002478	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The Pakistani and the Australian CYP337B3 alleles differ by 18 synonymous and three nonsynonymous SNPs and additionally in the length and sequence of the intron.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002479	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002480	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002481	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002482	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002483	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002484	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Insertion	Helicoverpa zea corn earworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...] 1 Additional References Valencia-Montoya WA; Elfekih S; North HL (2020) Adaptive Introgression across Semipermeable Species Boundaries between Local Helicoverpa zea and Inv[...]	GP00002485	CYP337B3 A0A0H3V333	Physiology	Introgression of the CYP337B3v2 resistant allele from Helicoverpa armigera	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		CYP337B3	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
CYP392A16	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Papapostolou KM; Riga M; Samantsidis GR (2022) Over-expression in cis of the midgut P450 CYP392A16 contributes to abamectin resistance in Tetranych[...]	GP00002471	Ace P07140	Physiology	several non-synonymous SNP - exact causing amino acid change(s) unknown. Functional analysis of the putative promoter region from the resistant and susceptible parental strains revealed a higher reporter gene expression confirming the presence of cis-acting regulatory mechanisms.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		CYP392A16	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CYP392E8	Xenobiotic resistance	Cis-regulatory, Unknown	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Linkage Mapping	Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021) High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]	GP00002397		Physiology	increase in transcription of CYP392E8.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		CYP392E8	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CYP4F2	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000203	CYP4F2 P78329	Physiology	V433M	Homo sapiens human - (species)	Homo sapiens human - (species)		CYP4F2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP6AB3	Xenobiotic resistance (imperatorin)	Coding, SNP	Depressaria pastinacella (species)	Intraspecific	Candidate Gene	Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007) Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]	GP00000204	CYP6AB3 Q7YZS3	Physiology	Ala92Val (and potentiallly 4 other a.a. substitutions)	Depressaria pastinacella (species)	Depressaria pastinacella (species)		CYP6AB3	Depressaria pastinacella (species)	Published - Accepted by Curator
CYP6AY1	Xenobiotic resistance (imidacloprid; buprofezin)	Cis-regulatory, Unknown	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Pang R; Li Y; Dong Y ; et al. (2014) Identification of promoter polymorphisms in the cytochrome P450 CYP6AY1 linked with insecticide resi[...]	GP00002399	CYP6AY1 A0A1L1VFS3	Physiology	CYP6AY1 is expressed at a higher level in a field-collected BPH strain that is highly resistant to both imidacloprid and buprofezin. Polymorphism in the promoter region associated with various levels of resistance.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6AY1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6BG1	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Li X; Shan C; Li F ; et al. (2019) Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resista[...] 1 Additional References Mallott M; Hamm S; Troczka BJ (2019) A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]	GP00002064	CYP6BG1 A0A222NX20	Physiology	promoters tested in luciferase assays	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		CYP6BG1	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
CYP6CM1	Xenobiotic resistance (insecticide; imidacloprid)	Cis-regulatory, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Karunker I; Benting J; Lueke B ; et al. (2008) Over-expression of cytochrome P450 CYP6CM1 is associated with high resistance to imidacloprid in the[...]	GP00002608	A0A6C0PTH9	Physiology	three single-nucleotide polymorphic (SNP) markers in the intron region of CYP6CM1 that discriminate between the resistant and susceptible CYP6CM1 alleles	Bemisia tabaci (species)	Bemisia tabaci (species) D		CYP6CM1	Bemisia tabaci (species)	Published - Accepted by Curator
CYP6CY3	Xenobiotic resistance (insecticide; neonicotinoid; host plant)	Cis-regulatory, Insertion	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Zimmer CT; Riveron JM ; et al. (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift. 1 Additional References Bass C; Zimmer CT; Riveron JM (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift.	GP00001474	CYP6CY3 V5SQ25	Physiology	Expansion of a AC dinucleotide microsatellite (from 15 to 48 repeat units) in the promoter 198 bp upstream of the start codon that enhances gene expression	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		CYP6CY3	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
CYP6CY3-CYP6CY4	Xenobiotic resistance (insecticide; neonicotinoid; host plant)	Gene Amplification, Insertion	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Zimmer CT; Riveron JM ; et al. (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift. 3 Additional References Puinean AM; Foster SP; Oliphant L (2010) Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides [...] Bass C; Zimmer CT; Riveron JM (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift. Singh KS; Troczka BJ; Duarte A (2020) The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont f[...]	GP00001473	CYP6CY3 V5SQ25	Physiology	gene amplification (from 2 to 14-100 copies) - CYP6CY3 and neighboring gene CYP6CY4 are duplicated in M. p. nicotianae as a large amplicon of ~325 kb creating characteristic breakpoints identifying the region. CYP6CY4 and CYP6CY3 are highly effective at metabolizing nicotine to its nontoxic metabolite cotinine.	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		CYP6CY3-CYP6CY4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
CYP6D1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Gao J; Scott JG (2006) Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the hou[...]	GP00002118	CYP6D1 Q27698	Physiology	15 bp insertion which disrupts a putative mdGfi-1 binding site in the CYP6D1v1 promoter. mdGfi-1 is a negative regulator of transcription so this leads to increased expression of CYP6D1	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		CYP6D1	Musca domestica house fly - (species)	Published - Accepted by Curator
cyp6d2	Xenobiotic resistance (chemotherapeutic agent, camptothecin)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Thomas AM; Hui C; South A ; et al. (2013) Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]	GP00001983	Cyp6g2 Q9V675	Physiology	G>C in CATAGgtaagga...caagCTCT so that intron 3 is not spliced and the codon GCT (spanning the intron) is transformed into CCT. The splicing is defective and intron 3 is transcribed and results in a stop codon and a protein truncated from its native C terminal part.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		cyp6d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6d2	Xenobiotic resistance (chemotherapeutic agent, camptothecin)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Thomas AM; Hui C; South A ; et al. (2013) Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]	GP00001984	Cyp6g2 Q9V675	Physiology	N438T (A22652974C) and N439T (A22652978G) - exact causing mutation(s) not identified - semiquantitative RT-PCR revealed that this mutant produces little to no Cyp6d2 transcript. The mutation is thus also cis-regulatory.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		cyp6d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002472	cyp6er1 A0A2I8B6P1	Physiology	T318S substitution results in a marked (20-fold) and significant increase in resistance compared to the wild-type susceptible variant.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, Deletion	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002473	cyp6er1 A0A2I8B6P1	Physiology	Deletion of Pro377. This provides a more moderate but significant 4.5-fold increase in resistance.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, Complex Change	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002474	cyp6er1 A0A2I8B6P1	Physiology	A375del+A376G	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Cis-regulatory, Unknown	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002475	cyp6er1 A0A2I8B6P1	Physiology	A significant (up to 9.5-fold) increase in expression driven by the promoter of CYP6ER1vA was observed in comparison to all other promoter variants. This suggests that cis-acting elements in the region upstream of CYP6ER1vA are responsible for the high expression of this variant in BPH populations across Southeast Asia.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6FU1	Xenobiotic resistance (insecticide; deltamethrin)	Cis-regulatory, Unknown	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Pu J; Sun H; Wang J ; et al. (2016) Multiple cis-acting elements involved in up-regulation of a cytochrome P450 gene conferring resistan[...]	GP00002117	CYP6FU1 A0A1S5R631	Physiology	Four cis-acting elements were identified whose influence on up-regulation was much more pronounced in combination than when present singly.	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D		CYP6FU1	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	4 Mutations: Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chung H; Bogwitz MR; McCart C ; et al. (2007) Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]	GP00000207	Cyp6g1 Q9V674	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		cyp6g1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Schlenke TA; Begun DJ (2004) Strong selective sweep associated with a transposon insertion in Drosophila simulans.	GP00002019	Cyp6g1 Q9V674	Physiology	insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D		cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013) Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]	GP00002020	Cyp6g1 Q9V674	Physiology	insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D		cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Riveron JM; Irving H; Ndula M ; et al. (2013) Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...] 1 Additional References Mugenzi LMJ; Menze BD; Tchouakui M (2019) Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy ag[...]	GP00000208	CYP2C9 P11712	Physiology	Cis-regulatory variation in CYP6P9b gene	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D		CYP6P9 cluster (CYP6P9a and CYP6P9b)	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP6P9; CYP6P4 cluster	Xenobiotic resistance (insecticide)	5 Mutations:	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Wondji CS; Irving H; Morgan J ; et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...] 2 Additional References Weedall GD; Mugenzi LMJ; Menze BD (2019) A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing i[...] Wondji CS; Hearn J; Irving H (2022) RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ h[...]	GP00000209	Q2YH43	Physiology	5 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D		CYP6P9; CYP6P4 cluster	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP79D15	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000211	CYP79D15 B2Y2T9	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D		CYP79D15	Trifolium repens white clover - (species)	Published - Accepted by Curator
CYP81F2	Glucosinolate content Herbivore resistance (aphids)	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pfalz M; Vogel H; Kroymann J (2009) The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole gluco[...]	GP00000212	CYP81F2 Q9LVD6	Physiology Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		CYP81F2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CYP9A	Xenobiotic resistance (insecticide; deltamethrin)	Gene Amplification, Insertion	Spodoptera frugiperda fall armyworm - (species)	Intraspecific	Association Mapping	Gimenez S; Abdelgaffar H; Goff GL ; et al. (2020) Adaptation by copy number variation increases insecticide resistance in the fall armyworm.	GP00002476		Physiology	In sensitive alleles the gene cluster is composed of 12 CYP9A genes and two alcohol dehydrogenase genes. All 30 resistant alleles have two copies of this unit while 28 and 6 alleles of the sensitive individuals had one and two copies; respectively.	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species)		CYP9A	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
CYP9A186	Xenobiotic resistance (insecticide; avermectin; emamectin benzoate; abamectin)	Coding, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Zuo Y; Shi Y; Zhang F ; et al. (2021) Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in[...]	GP00002393	CYP9A186 A0A8E4AAI2	Physiology	Heterologous expression and in vitro functional assays further confirm that a natural substitution (F116V) found in the substrate recognition site 1 (SRS1) of the CYP9A186 protein results in enhanced metabolism of EB and abamectin	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		CYP9A186	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
CYP9J26	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Bariami V; Jones CM; Poupardin R ; et al. (2012) Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]	GP00002606	CYP9J Q8T4S7	Physiology	CYP9J26 gene amplified about 6–7 times	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		CYP9J26	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)	Coding, SNP	Plasmopara viticola (species) D	Intraspecific	Candidate Gene	Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007) At least two origins of fungicide resistance in grapevine downy mildew populations.	GP00002041	UQCRFS1 P47985	Physiology	Gly143Ala G1256C	Plasmopara viticola (species)	Plasmopara viticola (species) D		cytochrome b	Plasmopara viticola (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)	Coding, SNP	Plasmopara viticola (species) D	Intraspecific	Candidate Gene	Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007) At least two origins of fungicide resistance in grapevine downy mildew populations.	GP00002042	UQCRFS1 P47985	Physiology	Gly143Ala G1256C	Plasmopara viticola (species)	Plasmopara viticola (species) D		cytochrome b	Plasmopara viticola (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; myxothiazol)	Coding, SNP	Chlamydomonas reinhardtii (species) D	Intraspecific	Candidate Gene	Bennoun P; Delosme M; Kück U (1991) Mitochondrial genetics of Chlamydomonas reinhardtii: resistance mutations marking the cytochrome b g[...]	GP00002043	UQCRFS1 P47985	Physiology	F129L	Chlamydomonas reinhardtii (species)	Chlamydomonas reinhardtii (species) D		cytochrome b	Chlamydomonas reinhardtii (species)	Published - Accepted by Curator
cytochrome c oxidase (COX7A)	Fertility Lifespan Locomotor activity	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Melvin RG; Katewa SD; Ballard JW (2008) A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...] 1 Additional References Ballard JW; Melvin RG (2011) Early life benefits and later life costs of a two amino acid deletion in Drosophila simulans.	GP00001980	COX7A Q9VHS2	Physiology Physiology Physiology	Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.	Drosophila simulans (species)	Drosophila simulans (species) D		cytochrome c oxidase (COX7A)	Drosophila simulans (species)	Published - Accepted by Curator
Darkener of apricot (Doa)	Lifespan	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Hoedjes KM; Kostic H; Keller L ; et al. (2022) Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity.	GP00002662	Doa P49762	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Darkener of apricot (Doa)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
DC-STAMP domain containing 2 (DCST2)	Body size	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	van der Valk RJ; Kreiner-Møller E; Kooijman MN ; et al. (2015) A novel common variant in DCST2 is associated with length in early life and height in adulthood.	GP00001509	DCST2 Q5T1A1	Morphology	SNP rs905938 C allele associated with an increase in birth length but probably not the causative mutation	Homo sapiens human - (species)	Homo sapiens human - (species)		DC-STAMP domain containing 2 (DCST2)	Homo sapiens human - (species)	Published - Accepted by Curator
Dca (=smp-30)	Wing size	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lee SF; Chen Y; Varan AK ; et al. (2011) Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence a[...] 1 Additional References McKechnie SW; Blacket MJ; Song SV (2010) A clinally varying promoter polymorphism associated with adaptive variation in wing size in Drosophi[...]	GP00000214	smp-30 Q9VFG5	Morphology	Non-coding	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Dca (=smp-30)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
DDB1	Resistance to UV irradiation (sun exposure to skin)	Cis-regulatory, Complex Change	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Crawford NG; Kelly DE; Hansen MEB ; et al. (2017) Loci associated with skin pigmentation identified in African populations.	GP00001363	DDB1 Q16531	Morphology	most strongly associated SNPs are located in a region conserved across vertebrates flanked by TMEM138 and TMEM216 ~36 to 44 kb upstream of DDB1 and in high LD ; includes rs7948623 located 172 bp downstream of TMEM138 which shows enhancer activity in melanoma cells and interacts with the promoters of DDB1	Homo sapiens human - (species)	Homo sapiens human - (species) D		DDB1	Homo sapiens human - (species)	Published - Accepted by Curator
Delta	Bristle number (abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Langley CH ; et al. (1998) Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in [...] 1 Additional References Genissel A; Pastinen T; Dowell A (2004) No evidence for an association between common nonsynonymous polymorphisms in delta and bristle numbe[...]	GP00000216	Dl P10041	Morphology	unknown; associated site in intron 5	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Delta	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Delta	Bristle number (thorax)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Langley CH ; et al. (1998) Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in [...] 1 Additional References Genissel A; Pastinen T; Dowell A (2004) No evidence for an association between common nonsynonymous polymorphisms in delta and bristle numbe[...]	GP00000217	Dl P10041	Morphology	unknown; associated site in intron 2	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Delta	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Delta-1-pyrroline-5-carboxylate synthase A	Drought response (drought-induced proline accumulation)	2 Mutations: Coding	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kesari R; Lasky JR; Villamor JG ; et al. (2012) Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation[...]	GP00001280	P5CSA P54887	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Delta-1-pyrroline-5-carboxylate synthase A	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
desaturase 2 (desat2)	Pheromone production	Cis-regulatory, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Takahashi A; Tsaur SC; Coyne JA ; et al. (2001) The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila m[...] 1 Additional References Dallerac R; Labeur C; Jallon JM (2000) A delta 9 desaturase gene with a different substrate specificity is responsible for the cuticular di[...]	GP00000221	Desat2 Q9VG68	Physiology	16bp deletion about 150bp upstream of transcription start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		desaturase 2 (desat2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
determinant of gall color (dgc)	Coloration (induced gall)	Cis-regulatory, Unknown	Hormaphis cornu (species)	Intraspecific	Association Mapping	Korgaonkar A; Han C; Lemire AL ; et al. (2021) A novel family of secreted insect proteins linked to plant gall development.	GP00002392		Morphology	almost complete silencing of dgc expression in salivary glands of aphids carrying the red gall allele	Hormaphis cornu (species)	Hormaphis cornu (species)		determinant of gall color (dgc)	Hormaphis cornu (species)	Published - Accepted by Curator
Dihydroflavonol 4 reductase (MlDfr)	Coloration (flower)	Coding, Insertion N	Erythranthe lewisii (species) D	Intraspecific	Candidate Gene	Wu CA; Streisfeld MA; Nutter LI ; et al. (2013) The genetic basis of a rare flower color polymorphism in Mimulus lewisii provides insight into the r[...]	GP00001457	DFRA P51102	Morphology	A 2 nt (TG) insertion at position 265 causing a frameshift and a greatly truncated protein of 106 aa only about one-fourth of its functional length N	Erythranthe lewisii (species)	Erythranthe lewisii (species) D		Dihydroflavonol 4 reductase (MlDfr)	Erythranthe lewisii (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (flowers)	Coding, Deletion	Iochroma calycinum (species) D	Intraspecific	Candidate Gene	Coburn RA; Griffin RH; Smith SD (2015) Genetic basis for a rare floral mutant in an Andean species of Solanaceae.	GP00000224	DFRA P51102	Morphology	33bp (11 a.a) deletion In coding sequence	Iochroma calycinum (species)	Iochroma calycinum (species) D		dihydroflavonol reductase (DFR)	Iochroma calycinum (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (flowers)	Coding, SNP	Iochroma cyaneum (species)	Intraspecific	Linkage Mapping	Smith SD; Rausher MD (2011) Gene loss and parallel evolution contribute to species difference in flower color.	GP00000225	DFRA P51102	Morphology	12 candidate a.a. substitution in cluding one at a residue known to influence substrate specificity	Iochroma cyaneum (species)	Iochroma cyaneum (species)		dihydroflavonol reductase (DFR)	Iochroma cyaneum (species)	Published - Accepted by Curator
Dihydrofolate reductase (pvdhfr)	Xenobiotic resistance (pyrimethamine)	Unknown, Unknown	Plasmodium vivax malaria parasite P. vivax - (species) D	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001484	DHFR P00374	Physiology	unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species) D		Dihydrofolate reductase (pvdhfr)	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
Dihydropteroate synthase (pvdhps)	Xenobiotic resistance (sulfadoxine)	Unknown, Unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001485	DHPS Q00LX9	Physiology	unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species)		Dihydropteroate synthase (pvdhps)	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Unckless RL; Rottschaefer SM; Lazzaro BP (2015) The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster. 1 Additional References Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.	GP00000227	DptA P24492	Physiology	Ser>Arg (AGC>AGA)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Diptericin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila. 1 Additional References Unckless RL; Lazzaro BP (2016) The potential for adaptive maintenance of diversity in insect antimicrobial peptides.	GP00000228	DptA P24492	Physiology	Ser>Arg (AGC>AGG)	Drosophila simulans (species)	Drosophila simulans (species)		Diptericin	Drosophila simulans (species)	Published - Accepted by Curator
Distorter on the X (Dox)	Sex determination (sex ratio distortion)	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Tao Y; Araripe L; Kingan SB ; et al. (2007) A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.	GP00001969		Physiology	Deletion of 105bp, resulting in the loss of exon III, which deletes one of the 42bp elements that is tandemly repeated in wild-type Dsim\Dox.	Drosophila simulans (species)	Drosophila simulans (species) D		Distorter on the X (Dox)	Drosophila simulans (species)	Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)	Seed dormancy	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Bentsink L; Jowett J; Hanhart CJ ; et al. (2006) Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis. 3 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Horton MW; Hancock AM; Huang YS (2012) Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegM[...] Nakabayashi K; Bartsch M; Ding J (2015) Seed Dormancy in Arabidopsis Requires Self-Binding Ability of DOG1 Protein and the Presence of Multi[...]	GP00000231	DOG1 A0SVK0	Physiology	Not identified (possibly polyallelic as each cross to the Ler accession showed different DOG1 effects)	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		DOG1 (DELAY OF GERMINATION 1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)	Seed dormancy	Cis-regulatory, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Kerdaffrec E; Filiault DL; Korte A ; et al. (2016) Multiple alleles at a single locus control seed dormancy in Swedish Arabidopsis.	GP00001397	DOG1 A0SVK0	Physiology	At least 3 haplotypes defined by 4 SNPs in a putative regulatory region of DOG-1.	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		DOG1 (DELAY OF GERMINATION 1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Dopa oxidase-3 (Dox-3)	Enzymatic activity	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Asada N (1997) Genetic variants affecting phenoloxidase activity in Drosophila melanogaster.	GP00002000		Physiology	Exact causing mutation(s) unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Dopa oxidase-3 (Dox-3)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Dopa-decarboxylase	Bristle number (abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Mackay TF; Lyman RF (2005) Drosophila bristles and the nature of quantitative genetic variation.	GP00000232	Ddc P05031	Morphology	Promoter variation	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Dopa-decarboxylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Dopa-decarboxylase	Lifespan	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	De Luca M; Roshina NV; Geiger-Thornsberry GL ; et al. (2003) Dopa decarboxylase (Ddc) affects variation in Drosophila longevity.	GP00000233	Ddc P05031	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Dopa-decarboxylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Doublesex	Coloration (wing ; Batesian mimicry)	Unknown, Unknown	Papilio polytes common Mormon - (species)	Intraspecific	Linkage Mapping	Kunte K; Zhang W; Tenger-Trolander A ; et al. (2014) doublesex is a mimicry supergene. 2 Additional References Nishikawa H; Iijima T; Kajitani R (2015) A genetic mechanism for female-limited Batesian mimicry in Papilio butterfly. Zhang W; Westerman E; Nitzany E (2017) Tracing the origin and evolution of supergene mimicry in butterflies.	GP00001966	dsx P23023	Morphology	More than 1000 nucleotide substitutions differentiate mimetic and non-mimetic dsx alleles. The non-mimetic Cyrus Dsx protein folds much like other insects (such as Bombyx mori) whereas the mimetic polytes protein structure is highly divergent. Knockdown experiments show that female-specific dsx isoforms expressed from the inverted H allele (dsx(H)) induce mimetic coloration patterns and simultaneously repress non-mimetic patterns.	Papilio polytes common Mormon - (species)	Papilio polytes common Mormon - (species)		Doublesex	Papilio polytes common Mormon - (species)	Published - Accepted by Curator
Doublesex	Coloration (wing ; Batesian mimicry)	Unknown, Unknown	Papilio memnon (species)	Intraspecific	Candidate Gene	Iijima T; Kajitani R; Komata S ; et al. (2018) Parallel evolution of Batesian mimicry supergene in two Papilio butterflies, P. polytes and P. memno[...] 1 Additional References Komata S; Lin CP; Iijima T (2016) Identification of doublesex alleles associated with the female-limited Batesian mimicry polymorphism[...]	GP00001967	dsx P23023	Morphology	A locus containing three genes (dsx; Nach-like and UXT) displays dimorphic sequences strictly associated with the mimetic/nonmimetic phenotypes. Expression of dox; UXT but not Nach-like showed differences correlated with phenotype in female hind wings.	Papilio memnon (species)	Papilio memnon (species)		Doublesex	Papilio memnon (species)	Published - Accepted by Curator
drh-1	Pathogen resistance (viral immunity)	Coding, Deletion	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Ashe A; Bélicard T; Le Pen J ; et al. (2013) A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and an[...]	GP00001308	drh-1 G5EDI8	Physiology	159 base deletion in CDS resulting in truncated but potentially non-null protein	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		drh-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Drip	Fertility	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Bergland AO; Chae HS; Kim YJ ; et al. (2012) Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression an[...]	GP00000237	Drip Q9V5Z7	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Drip	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Drosomycin-like 5	Pathogen resistance (fungi)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002111	Drsl5 Q9VZR2	Physiology	Duplication of the gene and insertion of a 4993-bp region (which comes from part of a neighboring gene). Associated with a >1000-fold expression increase of the gene.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Drosomycin-like 5	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Duffy	Pathogen resistance (Plasmodium; malaria parasite) (malaria)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Tournamille C; Colin Y; Cartron JP ; et al. (1995) Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-n[...]	GP00000240	ACKR1 Q16570	Physiology	T to C substitution in 5' region at pos -46	Homo sapiens human - (species)	Homo sapiens human - (species)		Duffy	Homo sapiens human - (species)	Published - Accepted by Curator
DYM	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000242	DYM Q7RTS9	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		DYM	Homo sapiens human - (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)	Flowering time	Coding, Indel	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jiménez-Gómez JM; Wallace AD; Maloof JN (2010) Network analysis identifies ELF3 as a QTL for the shade avoidance response in Arabidopsis. 3 Additional References Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...] Coluccio MP; Sanchez SE; Kasulin L (2011) Genetic mapping of natural variation in a shade avoidance response: ELF3 is the candidate gene for a[...] Undurraga SF; Press MO; Legendre M (2012) Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3.	GP00000244	ELF3 O82804	Physiology	Background-dependent effects of extensive polyQ coding variation	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		EARLY FLOWERING 3(ELF3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3) [possible pseudo-replicate]	Plant growth (hypocotyl elongation ; temperature-dependent)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Raschke A; Ibañez C; Ullrich KK ; et al. (2015) Natural variants of ELF3 affect thermomorphogenesis by transcriptionally modulating PIF4-dependent a[...]	GP00001245	ELF3 O82804	Morphology	A362V	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		EARLY FLOWERING 3(ELF3) [possible pseudo-replicate]	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
early responsive to dehydration stress protein 4	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001434	ERD4 Q9C8G5	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		early responsive to dehydration stress protein 4	Arabidopsis arenosa (species)	Published - Accepted by Curator
EBF1	Body fat distribution (pericardial)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001554	EBF1 Q9UH73	Physiology	A>G & T>G in 2 associated SNPs	Homo sapiens human - (species)	Homo sapiens human - (species)		EBF1	Homo sapiens human - (species)	Published - Accepted by Curator
ebony	Coloration (abdomen)	Cis-regulatory, Unknown	Drosophila novamexicana (species) D	Intraspecific	Linkage Mapping	Wittkopp PJ; Stewart EE; Arnold LL ; et al. (2009) Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila. 1 Additional References Lamb Abigail M; Wang Zinan; Simmer Patricia (2020 ) ebony affects pigmentation divergence and cuticular hydrocarbons in Drosophila americana and D. nova[...]	GP00000248	e O76858	Morphology	Not identified	Drosophila americana (species)	Drosophila novamexicana (species) D		ebony	Drosophila novamexicana (species)	Published - Accepted by Curator
ebony	Coloration (thorax)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Takahashi A; Takahashi K; Ueda R ; et al. (2007) Natural variation of ebony gene controlling thoracic pigmentation in Drosophila melanogaster. 1 Additional References Endler L; Gibert JM; Nolte V (2018) Pleiotropic effects of regulatory variation in tan result in correlation of two pigmentation traits [...]	GP00000249	e O76858	Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	Cis-regulatory, Unknown	Drosophila auraria (species) D	Intraspecific	Candidate Gene	Johnson WC; Ordway AJ; Watada M ; et al. (2015) Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and betwee[...]	GP00000250	e O76858	Morphology	Inactivation of a conserved silencer resulting in gain-of-expression; the increase in ebony expression in the light strain occurred primarily through mutations affecting the ebony male-specific silencer element	Drosophila auraria (species)	Drosophila auraria (species) D		ebony	Drosophila auraria (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Takahashi A; Takano-Shimizu T (2011) Divergent enhancer haplotype of ebony on inversion In(3R)Payne associated with pigmentation variatio[...]	GP00000252	e O76858	Morphology	17 nucleotide sites and 2 indels in complete association with the thoracic trident pigmentation intensity in a 13kb region	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	5 Mutations: Cis-regulatory SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Rebeiz M; Pool JE; Kassner VA ; et al. (2009) Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population.	GP00000253	e O76858	Morphology	5 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ebony	Coloration (male-specific)	Cis-regulatory, SNP	Drosophila malerkotliana (species)	Intraspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001544	e O76858	Morphology	5 changes including 4 SNP and 1bp indel in the first intron	Drosophila malerkotliana (species)	Drosophila malerkotliana (species)		ebony	Drosophila malerkotliana (species)	Published - Accepted by Curator
ebony	Coloration (male-specific)	Cis-regulatory, Unknown	Drosophila pseudoananassae (species)	Intraspecific	Linkage Mapping	Signor SA; Liu Y; Rebeiz M ; et al. (2016) Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.	GP00001545	e O76858	Morphology	unknown	Drosophila pseudoananassae (species)	Drosophila pseudoananassae (species)		ebony	Drosophila pseudoananassae (species)	Published - Accepted by Curator
Ectodysplasin (EDA)	Scales (loss) Femoral glands (absent) Tooth number	Coding, Insertion	Pogona vitticeps central bearded dragon - (species) D	Intraspecific	Candidate Gene	Di-Poï N; Milinkovitch MC (2016) The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendage[...]	GP00002040	Eda O54693	Morphology Morphology Morphology	5′688–bp insertion of a transposon of the LTR-Gypsy family which generates a new splice donor site (gt) 42 bases upstream of the wild-type donor site; thus generating a 14–amino acid deletion in the corresponding transcript	Pogona vitticeps central bearded dragon - (species)	Pogona vitticeps central bearded dragon - (species) D		Ectodysplasin (EDA)	Pogona vitticeps central bearded dragon - (species)	Published - Accepted by Curator
EDAR	Hair thickness Eccrine gland density Ear traits = lobe size / lobe attachment / helix rolling / ear protrusion Tooth morphology (shovel-shaped incisors)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Fujimoto A; Kimura R; Ohashi J ; et al. (2008) A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickne[...] 4 Additional References Kamberov YG; Wang S; Tan J (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant. Adhikari K; Reales G; Smith AJ (2015) A genome-wide association study identifies multiple loci for variation in human ear morphology. Park JH; Yamaguchi T; Watanabe C (2012) Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits. Kimura R; Yamaguchi T; Takeda M (2009) A common variation in EDAR is a genetic determinant of shovel-shaped incisors.	GP00000256	EDAR Q9UNE0	Morphology Morphology Morphology Morphology	p.Val370Ala; functionally validated in mouse	Homo sapiens human - (species)	Homo sapiens human - (species) D		EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EGFR	Wing shape (length)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Dworkin I; Palsson A; Gibson G (2005) Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster. 1 Additional References Palsson A; Dodgson J; Dworkin I (2005) Tests for the replication of an association between Egfr and natural variation in Drosophila melanog[...]	GP00000259	Egfr P04412	Morphology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		EGFR	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
EGFR	Coloration (skin)	Unknown, Unknown	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Quillen EE; Bauchet M; Bigham AW ; et al. (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...]	GP00001537	EGFR P00533	Morphology	A>T associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species) D		EGFR	Homo sapiens human - (species)	Published - Accepted by Curator
egl-4 (Ppa-egl-4)	Insect pheromone attraction	Unknown, Unknown	Pristionchus pacificus (species)	Intraspecific	Association Mapping	Hong RL; Witte H; Sommer RJ (2008) Natural variation in Pristionchus pacificus insect pheromone attraction involves the protein kinase [...]	GP00000260	egl-4 O76360	Behavior	unknown	Pristionchus pacificus (species)	Pristionchus pacificus (species)		egl-4 (Ppa-egl-4)	Pristionchus pacificus (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 3 Additional References Bigham A; Bauchet M; Pinto D (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...] Xu S; Li S; Yang Y (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans. Xiang K; Ouzhuluobu ; Peng Y (2013) Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high[...]	GP00000261	EGLN1 Q9GZT9	Physiology	possibly D4E	Homo sapiens human - (species)	Homo sapiens human - (species) D		EGLN1	Homo sapiens human - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Bigham A; Bauchet M; Pinto D ; et al. (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...]	GP00000262	EGLN1 Q9GZT9	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		EGLN1	Homo sapiens human - (species)	Published - Accepted by Curator
EGLN1	High-altitude adaptation Hypoxia response	Unknown, Unknown	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	Graham AM; McCracken KG (2019) Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]	GP00002135	EGLN1 Q9GZT9	Physiology Physiology	probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		EGLN1	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
EGLN1	High-altitude adaptation Hypoxia response	Unknown, Unknown	Anas georgica yellow-billed pintail - (species) D	Intraspecific	Candidate Gene	Graham AM; McCracken KG (2019) Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]	GP00002136	EGLN1 Q9GZT9	Physiology Physiology	probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst	Anas georgica yellow-billed pintail - (species)	Anas georgica yellow-billed pintail - (species) D		EGLN1	Anas georgica yellow-billed pintail - (species)	Published - Accepted by Curator
EGNL1	High-altitude adaptation Hypoxia response	Cis-regulatory, Unknown	Anas cyanoptera cinnamon teal - (species) D	Intraspecific	Candidate Gene	Graham AM; McCracken KG (2019) Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]	GP00002134	EGLN1 Q9GZT9	Physiology Physiology	probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst	Anas cyanoptera cinnamon teal - (species)	Anas cyanoptera cinnamon teal - (species) D		EGNL1	Anas cyanoptera cinnamon teal - (species)	Published - Accepted by Curator
EIF2AK3	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000264	EIF2AK3 Q9NZJ5	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		EIF2AK3	Homo sapiens human - (species)	Published - Accepted by Curator
EIF2S2	Coloration (skin)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Liu F; Visser M; Duffy DL ; et al. (2015) Genetics of skin color variation in Europeans: genome-wide association studies with functional follo[...]	GP00001359	EIF2S2 P20042	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		EIF2S2	Homo sapiens human - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000267	END3 P39013	Physiology Physiology	S258N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000268	END3 P39013	Physiology Physiology	D268N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
engrailed	Coloration (wing ; Batesian mimicry)	Cis-regulatory, Unknown	Papilio dardanus African swallowtail butterfly - (species) D	Intraspecific	Linkage Mapping	Timmermans MJTN; Srivathsan A; Collins S ; et al. (2020) Mimicry diversification in Papilio dardanus via a genomic inversion in the regulatory region of engr[...]	GP00002428	en P02836	Morphology	Association with many nucleotide changes in a cis-regulatory region of engrailed. The diverged region exhibits a discrete chromosomal inversion of 40 kb relative to the ancestral orientation that is associated with the cenea morph, but not with the bottom-recessive hippocoonides morph or with non-mimetic allopatric populations.	Papilio dardanus African swallowtail butterfly - (species)	Papilio dardanus African swallowtail butterfly - (species) D		engrailed	Papilio dardanus African swallowtail butterfly - (species)	Published - Accepted by Curator
Enhanced shoot growth under mannitol stress 2 (EGM2)	Plant growth (shoot growth under stress)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Trontin C; Kiani S; Corwin JA ; et al. (2014) A pair of receptor-like kinases is responsible for natural variation in shoot growth response to man[...]	GP00001630	At1g11300 Q9SXB4	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Enhanced shoot growth under mannitol stress 2 (EGM2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ENSA	Body fat distribution (pericardial)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001558	ENSA O43768	Physiology	A>G in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		ENSA	Homo sapiens human - (species)	Published - Accepted by Curator
EPAS1	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 1 Additional References Xu S; Li S; Yang Y (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans.	GP00000274	EPAS1 Q99814	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		EPAS1	Homo sapiens human - (species)	Published - Accepted by Curator
EPAS1	Hypoxia response	Coding, SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Association Mapping	Schweizer RM; Velotta JP; Ivy CM ; et al. (2019) Physiological and genomic evidence that selection on the transcription factor Epas1 has altered card[...]	GP00002062	EPAS1 Q99814	Physiology	non-synonymous polymorphism located at site 755 in the 14th exon that changes threonine to methionine Thr755Met	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		EPAS1	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
EPAS1	High-altitude adaptation Hypoxia response	Unknown, Unknown	Anas cyanoptera cinnamon teal - (species) D	Intraspecific	Candidate Gene	Graham AM; McCracken KG (2019) Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]	GP00002131	EPAS1 Q99814	Physiology Physiology	several candidate coding mutations	Anas cyanoptera cinnamon teal - (species)	Anas cyanoptera cinnamon teal - (species) D		EPAS1	Anas cyanoptera cinnamon teal - (species)	Published - Accepted by Curator
EPAS1	High-altitude adaptation Hypoxia response	Unknown, Unknown	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	Graham AM; McCracken KG (2019) Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]	GP00002132	EPAS1 Q99814	Physiology Physiology	several candidate coding mutations	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		EPAS1	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
EPAS1	High-altitude adaptation Hypoxia response	Unknown, Unknown	Anas georgica yellow-billed pintail - (species) D	Intraspecific	Candidate Gene	Graham AM; McCracken KG (2019) Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]	GP00002133	EPAS1 Q99814	Physiology Physiology	several candidate coding mutations	Anas georgica yellow-billed pintail - (species)	Anas georgica yellow-billed pintail - (species) D		EPAS1	Anas georgica yellow-billed pintail - (species)	Published - Accepted by Curator
Epithiospecifier Modifier1 (ESM1)	Nitrile content	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Zhang Z; Ober JA; Kliebenstein DJ (2006) The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hy[...]	GP00000277	ESM1 Q9LJG3	Physiology	Not identified	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Epithiospecifier Modifier1 (ESM1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Epithiospecifier protein (ESP)	Plant secondary metabolite (glucosinolate) Herbivore resistance	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001) The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]	GP00000278	ESP Q8RY71	Physiology Physiology	Not identified	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Epithiospecifier protein (ESP)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Epithiospecifier protein (ESP)	Plant secondary metabolite (glucosinolate) Herbivore resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001) The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]	GP00000279	ESP Q8RY71	Physiology Physiology	deletion of 124 bases that eliminates a splice site and 100 nucleotides of the ORF N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Epithiospecifier protein (ESP)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Gene Amplification, Insertion	Amaranthus palmeri (species) D	Intraspecific	Candidate Gene	Gaines TA; Zhang W; Wang D ; et al. (2010) Gene amplification confers glyphosate resistance in Amaranthus palmeri.	GP00001883	At2g45300 P05466	Physiology	Genomes of resistant plants contain from 5-fold to more than 160-fold more copies of the EPSPS gene than did genomes of susceptible plants - the duplicated section of DNA including the 10 kb EPSPS gene is at least 30 kb long	Amaranthus palmeri (species)	Amaranthus palmeri (species) D		EPSPS	Amaranthus palmeri (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Gene Amplification, Insertion	Amaranthus tuberculatus (species) D	Intraspecific	Candidate Gene	Tranel PJ; Riggins CW; Bell MS ; et al. (2011) Herbicide resistances in Amaranthus tuberculatus: a call for new options.	GP00001884	At2g45300 P05466	Physiology	4 copies of the EPSPS gene	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		EPSPS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Gene Amplification, Insertion	Lolium multiflorum Italian ryegrass - (species) D	Intraspecific	Candidate Gene	Salas RA; Dayan FE; Pan Z ; et al. (2012) EPSPS gene amplification in glyphosate-resistant Italian ryegrass (Lolium perenne ssp. multiflorum) [...]	GP00001885	At2g45300 P05466	Physiology	15-25 copies of the EPSPS gene	Lolium multiflorum Italian ryegrass - (species)	Lolium multiflorum Italian ryegrass - (species) D		EPSPS	Lolium multiflorum Italian ryegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Gene Amplification, Insertion	Bassia scoparia (species) D	Intraspecific	Candidate Gene	Sammons RD; Gaines TA (2014) Glyphosate resistance: state of knowledge.	GP00001886	At2g45300 P05466	Physiology	15-25 copies of the EPSPS gene	Bassia scoparia (species)	Bassia scoparia (species) D		EPSPS	Bassia scoparia (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Gene Amplification, Insertion	Amaranthus spinosus (species) D	Intraspecific	Candidate Gene	Sammons RD; Gaines TA (2014) Glyphosate resistance: state of knowledge.	GP00001887	At2g45300 P05466	Physiology	26-37 copies of the EPSPS gene	Amaranthus spinosus (species)	Amaranthus spinosus (species) D		EPSPS	Amaranthus spinosus (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Eleusine indica goosegrass - (species) D	Intraspecific	Candidate Gene	Baerson SR; Rodriguez DJ; Tran M ; et al. (2002) Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshik[...]	GP00001888	At2g45300 P05466	Physiology	Pro106Ser leading to 2-4-fold resistance	Eleusine indica goosegrass - (species)	Eleusine indica goosegrass - (species) D		EPSPS	Eleusine indica goosegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Echinochloa colona (species) D	Intraspecific	Candidate Gene	Morran S; Moretti ML; Brunharo CA ; et al. (2018) Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]	GP00001889	At2g45300 P05466	Physiology	Pro106Ser leading to resistance	Echinochloa colona (species)	Echinochloa colona (species) D		EPSPS	Echinochloa colona (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Echinochloa colona (species) D	Intraspecific	Candidate Gene	Morran S; Moretti ML; Brunharo CA ; et al. (2018) Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]	GP00001890	At2g45300 P05466	Physiology	Pro106Leu leading to resistance	Echinochloa colona (species)	Echinochloa colona (species) D		EPSPS	Echinochloa colona (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Echinochloa colona (species) D	Intraspecific	Candidate Gene	Morran S; Moretti ML; Brunharo CA ; et al. (2018) Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]	GP00001891	At2g45300 P05466	Physiology	Pro106Thr leading to resistance	Echinochloa colona (species)	Echinochloa colona (species) D		EPSPS	Echinochloa colona (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Candidate Gene	Bell Michael S; Hager Aaron G; Tranel Patrick J (2013 ) Multiple resistance to herbicides from four site-of-action groups in waterhemp (Amaranthus tubercula[...]	GP00001892	At2g45300 P05466	Physiology	resistance not due to EPSPS amplification; partly due to P106S mutation	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		EPSPS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium multiflorum Italian ryegrass - (species) D	Intraspecific	Candidate Gene	Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008 ) Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]	GP00001896	At2g45300 P05466	Physiology	Pro106Ser	Lolium multiflorum Italian ryegrass - (species)	Lolium multiflorum Italian ryegrass - (species) D		EPSPS	Lolium multiflorum Italian ryegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium multiflorum Italian ryegrass - (species) D	Intraspecific	Candidate Gene	Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008 ) Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]	GP00001897	At2g45300 P05466	Physiology	Pro106Ala conferring 5-15-fold resistance	Lolium multiflorum Italian ryegrass - (species)	Lolium multiflorum Italian ryegrass - (species) D		EPSPS	Lolium multiflorum Italian ryegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Eleusine indica goosegrass - (species) D	Intraspecific	Candidate Gene	Ng CH; Wickneswari R; Salmijah S ; et al. (2003 ) Gene polymorphisms in glyphosate‐resistant and‐susceptible biotypes of Eleusine indica from Malaysia[...]	GP00001898	At2g45300 P05466	Physiology	Pro106Thr leading to 3-fold resistance	Eleusine indica goosegrass - (species)	Eleusine indica goosegrass - (species) D		EPSPS	Eleusine indica goosegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Digitaria insularis (species) D	Intraspecific	Candidate Gene	de Carvalho LB; Alves PL; González-Torralva F ; et al. (2012) Pool of resistance mechanisms to glyphosate in Digitaria insularis.	GP00001899	At2g45300 P05466	Physiology	Pro106Thr	Digitaria insularis (species)	Digitaria insularis (species) D		EPSPS	Digitaria insularis (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Kaundun SS; Dale RP; Zelaya IA ; et al. (2011) A novel P106L mutation in EPSPS and an unknown mechanism(s) act additively to confer resistance to g[...]	GP00001900	At2g45300 P05466	Physiology	Pro106Leu conferring a 1.7-fold resistance increase to glyphosate at the whole plant level	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012 ) Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]	GP00001901	At2g45300 P05466	Physiology	Pro106Ser	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012 ) Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]	GP00001902	At2g45300 P05466	Physiology	Pro106Thr	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Yu Q; Cairns A; Powles S (2007) Glyphosate, paraquat and ACCase multiple herbicide resistance evolved in a Lolium rigidum biotype.	GP00001903	At2g45300 P05466	Physiology	Pro106Ala	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
ERECTA	Plant architecture Leaf architecture Transpiration	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Masle J; Gilmore SR; Farquhar GD (2005) The ERECTA gene regulates plant transpiration efficiency in Arabidopsis. 2 Additional References El-Lithy ME; Reymond M; Stich B (2010) Relation among plant growth, carbohydrates and flowering time in the Arabidopsis Landsberg erecta x [...] Huang X; Paulo MJ; Boer M (2011) Analysis of natural allelic variation in Arabidopsis using a multiparent recombinant inbred line pop[...]	GP00000280	ERECTA Q42371	Morphology Morphology Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ERECTA	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ERECTA	Pathogen resistance (Cucumerina fungus)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Llorente F; Alonso-Blanco C; Sánchez-Rodriguez C ; et al. (2005) ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resistanc[...]	GP00001244	ERECTA Q42371	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ERECTA	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000281	ERG11 P10613	Physiology	Y132H	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000282	ERG11 P10613	Physiology	S405F	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000283	ERG11 P10613	Physiology	G464S	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000284	ERG11 P10613	Physiology	R467K	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, Indel	Candida albicans (species)	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00000285	ERG11 P10613	Physiology	Copy number Variant	Candida albicans (species)	Candida albicans (species)		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ESR1	Aggression behavior	Cis-regulatory, Unknown	Zonotrichia albicollis white-throated sparrow - (species) D	Intraspecific	Linkage Mapping	Merritt JR; Grogan KE; Zinzow-Kramer WM ; et al. (2020) A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.	GP00002440	Esr1 P19785	Behavior	Increase in expression of the gene in the white-striped morph. Differential allelic expression in heterozygotes.	Zonotrichia albicollis white-throated sparrow - (species)	Zonotrichia albicollis white-throated sparrow - (species) D		ESR1	Zonotrichia albicollis white-throated sparrow - (species)	Published - Accepted by Curator
esterase A8 and B8	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Qiao CL; Marquine M; Pasteur N ; et al. (1998) A new esterase gene amplification involved in OP resistance in Culex pipiens mosquitoes from China.	GP00002641	B1 P16854	Physiology	coamplification of both esterase loci (Est-2 and Est-3)	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		esterase A8 and B8	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
esterase B1	Xenobiotic resistance (insecticide; benzoylurea)	Gene Amplification, Complex Change	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Karunaratne SH; Vaughan A; Paton MG ; et al. (1998) Amplification of a serine esterase gene is involved in insecticide resistance in Sri Lankan Culex tr[...]	GP00000290	B1 P16854	Physiology	Whole gene amplification	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D		esterase B1	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
esterase B1 + esterase A	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Rooker S; Guillemaud T; Bergé J ; et al. (1996) Coamplification of esterase A and B genes as a single unit in Culex pipiens mosquitoes.	GP00000291	B1 P16854	Physiology	Amplification of a region containing both genes	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		esterase B1 + esterase A	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase B1 = esterase beta1	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Mouchès C; Pasteur N; Bergé JB ; et al. (1986) Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mo[...] 3 Additional References Guillemaud T; Raymond M; Tsagkarakou A (1999) Quantitative variation and selection of esterase gene amplification in Culex pipiens. Mouches C; Pauplin Y; Agarwal M (1990) Characterization of amplification core and esterase B1 gene responsible for insecticide resistance i[...] Guillemaud T; Rooker S; Pasteur N (1996) Testing the unique amplification event and the worldwide migration hypothesis of insecticide resista[...]	GP00000292	B1 P16854	Physiology	Amplification of esterase B1 only	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		esterase B1 = esterase beta1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase B4	Xenobiotic resistance (insecticide; chlorpyrifos)	Gene Amplification, Insertion	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Poirié M; Raymond M; Pasteur N (1992) Identification of two distinct amplifications of the esterase B locus in Culex pipiens (L.) mosquito[...]	GP00002639	B1 P16854	Physiology	The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		esterase B4	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
esterase B5	Xenobiotic resistance (insecticide; chlorpyrifos)	Gene Amplification, Insertion	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Poirié M; Raymond M; Pasteur N (1992) Identification of two distinct amplifications of the esterase B locus in Culex pipiens (L.) mosquito[...]	GP00002640	B1 P16854	Physiology	The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		esterase B5	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
esterase E4	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Field LM; Devonshire AL; Forde BG (1988) Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results[...] 2 Additional References Field LM; Blackman RL; Tyler-Smith C (1999) Relationship between amount of esterase and gene copy number in insecticide-resistant Myzus persicae[...] Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00000293	P35501	Physiology	Whole gene amplification. Amplification of the E4 gene is closely linked to a chromosomal translocation (the autosomal 1-3 translocation event) and amplified genes are situated at a single heterozygous site on autosome 3 as a tandem array of head-to-tail amplicons.	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		esterase E4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
esterase FE4	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Blackman RL; Spence JM; Field LM ; et al. (1999 ) Variation in the chromosomal distribution of amplified esterase (FE4) genes in Greek field populatio[...] 2 Additional References Field LM; Blackman RL; Tyler-Smith C (1999) Relationship between amount of esterase and gene copy number in insecticide-resistant Myzus persicae[...] Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00002642	P35502	Physiology	Gene amplification	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		esterase FE4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Newcomb RD; Campbell PM; Ollis DL ; et al. (1997) A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]	GP00000294	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)		esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Jackson CJ; Liu JW; Carr PD ; et al. (2013) Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]	GP00000295	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)		esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species)	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000296	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species)		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000297	LcaE7 Q25252	Physiology	Trp251Ser	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000298	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. de Carvalho RA; Torres TT; de Azeredo-Espin AM (2006) A survey of mutations in the Cochliomyia hominivorax (Diptera: Calliphoridae) esterase E3 gene assoc[...]	GP00002584	alphaE7 A0A0G3Z837	Physiology	G137D	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D		esterase isozyme E3	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
esterase isozyme E7 = E3	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Claudianos C; Russell RJ; Oakeshott JG (1999) The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]	GP00000299	LcaE7 Q25252	Physiology	Gly137Asp	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		esterase isozyme E7 = E3	Musca domestica house fly - (species)	Published - Accepted by Curator
esterase NI-EST1	Xenobiotic resistance (organophosphorus insecticides)	Gene Amplification, Insertion	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Small GJ; Hemingway J (2000) Molecular characterization of the amplified carboxylesterase gene associated with organophosphorus i[...]	GP00002638	Ces1 Q8VCC2	Physiology	Southern analysis of genomic DNA from the Sri Lankan OP-resistant and susceptible strains suggests that the Nl-EST1 esterase gene is amplified in the resistant strain	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		esterase NI-EST1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
esterase type I	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Schizaphis graminum greenbug - (species) D	Intraspecific	Candidate Gene	Ono M; Swanson JJ; Field LM ; et al. (1999) Amplification and methylation of an esterase gene associated with insecticide-resistance in greenbug[...] 1 Additional References Vontas JG; Small GJ; Hemingway J (2000) Comparison of esterase gene amplification, gene expression and esterase activity in insecticide susc[...]	GP00002637	P35501	Physiology	The type I esterase is amplified 4- to 8-fold in resistant S. graminum and that the amplified sequences contain 5-methylcytosine at MspI/HpaII sites.	Schizaphis graminum greenbug - (species)	Schizaphis graminum greenbug - (species) D		esterase type I	Schizaphis graminum greenbug - (species)	Published - Accepted by Curator
ETC2	Trichome density (leaf)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Hilscher J; Schlötterer C; Hauser MT (2009) A single amino acid replacement in ETC2 shapes trichome patterning in natural Arabidopsis population[...]	GP00001237	ETC2 Q84RD1	Morphology	K19E	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ETC2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
eve	Developmental time	Cis-regulatory, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Palsson A; Wesolowska N; Reynisdóttir S ; et al. (2014) Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.	GP00001986	eve P06602	Physiology	72bp deletion that removes one of the hb protein-binding sites in the stripe 3+7 enhancer of eve. The deletion also removes half of a putative slp1 protein-binding site.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		eve	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
exp-1	Aggregation behavior	Cis-regulatory, Unknown	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Bendesky A; Pitts J; Rockman MV ; et al. (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...]	GP00000300	exp-1 G5ECJ0	Behavior	unidentified; 6.2kb wide genetic interval 3' of the exp-1 gene	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		exp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
F2RL2	Hematopoiesis (mean blood platelet volume)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001617	F2RL2 O00254	Physiology	A>T at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		F2RL2	Homo sapiens human - (species)	Published - Accepted by Curator
FAAH	Anxiety (fear reduction)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Dincheva I; Drysdale AT; Hartley CA ; et al. (2015) FAAH genetic variation enhances fronto-amygdala function in mouse and human.	GP00000301	Faah P97612	Behavior	Pro129Thr (C385A; common variant rs324420)	Homo sapiens human - (species)	Homo sapiens human - (species)		FAAH	Homo sapiens human - (species)	Published - Accepted by Curator
FAR (pheromone gland FAR)	Pheromone production (isomeric/chirality divergence)	Coding, Unknown	Ostrinia nubilalis European corn borer - (species)	Intraspecific	Linkage Mapping	Lassance JM; Groot AT; Liénard MA ; et al. (2010) Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones. 2 Additional References Lassance JM; Liénard MA; Antony B (2013) Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia [...] Unbehend M; Kozak GM; Koutroumpa F (2021) bric à brac controls sex pheromone choice by male European corn borer moths.	GP00000304	pgFAR D3U9W3	Physiology	Candidate a.a. substitutions with effect validated in vitro	Ostrinia nubilalis European corn borer - (species)	Ostrinia nubilalis European corn borer - (species)		FAR (pheromone gland FAR)	Ostrinia nubilalis European corn borer - (species)	Published - Accepted by Curator
fatty acyl-CoA reductase FAR2-B	Pheromone production (cuticular hydrocarbons)	Unknown, Unknown	Drosophila serrata (species)	Intraspecific	Linkage Mapping	Rusuwa BB; Chung H; Allen SL ; et al. (2022) Natural variation at a single gene generates sexual antagonism across fitness components in Drosophi[...]	GP00002395	Dmel\CG17560 Q9VES6	Physiology	Both alleles of DsFAR2-B appear to be functional. The distinction between the two alleles iss a large number of non-synonymous substitutions.	Drosophila serrata (species)	Drosophila serrata (species)		fatty acyl-CoA reductase FAR2-B	Drosophila serrata (species)	Published - Accepted by Curator
ferredoxin	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001530	PF3D7_1318100 Q8IED5	Physiology	p.Asp193Tyr	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		ferredoxin	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
Ferroportin 2	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001437	IREG2 F4KGN5	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		Ferroportin 2	Arabidopsis arenosa (species)	Published - Accepted by Curator
FGFR2	Hair thickness	Cis-regulatory, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Fujimoto A; Nishida N; Kimura R ; et al. (2009) FGFR2 is associated with hair thickness in Asian populations.	GP00000314	FGFR2 P21802	Morphology	Unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		FGFR2	Homo sapiens human - (species)	Published - Accepted by Curator
fibrinogen-related protein 1 (FREP1)	Pathogen resistance (Plasmodium; malaria parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001465	3290292 Q5TWN1	Physiology	c.T1325A p.Q442L	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		fibrinogen-related protein 1 (FREP1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
fibrinogen-related protein 30 (FBN30)	Pathogen resistance (parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001464	1270165 Q7QIK0	Physiology	c.T28C p.F10L	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		fibrinogen-related protein 30 (FBN30)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
fiz	Body size	3 Mutations: Cis-regulatory SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Glaser-Schmitt A; Parsch J (2018) Functional characterization of adaptive variation within a cis-regulatory element influencing Drosop[...]	GP00002017	fiz Q9VY04	Morphology	3 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		fiz	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Flavonoid 3'-5'-hydroxylase (F3'5'H)	Plant secondary metabolite (catechin)	Unknown, Unknown	Camellia sinensis (species)	Intraspecific	Linkage Mapping	Jin JQ; Ma JQ; Yao MZ ; et al. (2017) Functional natural allelic variants of flavonoid 3',5'-hydroxylase gene governing catechin traits in[...]	GP00001620	F3'5'H1 A3KLR7	Physiology	several candidate SNPs	Camellia sinensis (species)	Camellia sinensis (species)		Flavonoid 3'-5'-hydroxylase (F3'5'H)	Camellia sinensis (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000315	CYP75B1 Q9SD85	Morphology	-1bp at +973 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D		Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000316	CYP75B1 Q9SD85	Morphology	-1bp at +1164 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D		Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Indel	Glycine soja (species)	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000317	CYP75B1 Q9SD85	Morphology	a single base insertion of an adenine at position 965 as well as a single base deletion of adenine at position 973 resulting in N322K and Q324T - exact causing mutation(s) unknown	Glycine max soybean - (species)	Glycine soja (species)		Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers; pubescence; seeds)	Coding, Insertion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000322	CYP75A2 P37120	Morphology	53bp insertion at +1352 N	Glycine max soybean - (species)	Glycine soja (species) D		flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, SNP	Glycine soja (species)	Intraspecific	Linkage Mapping	Takahashi R; Dubouzet JG; Matsumura H ; et al. (2010) A new allele of flower color gene W1 encoding flavonoid 3'5'-hydroxylase is responsible for light pu[...]	GP00000323	CYP75A2 P37120	Morphology	V210M (uncertain); no expression level differences detected	Glycine soja (species)	Glycine soja (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Cis-regulatory, Unknown	Phlox drummondii (species)	Intraspecific	Linkage Mapping	Hopkins R; Rausher MD (2011) Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii.	GP00000325	CYP75A2 P37120	Morphology	unknown	Phlox drummondii (species)	Phlox drummondii (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Phlox drummondii (species)	Published - Accepted by Curator
FLC (=Pep1)	Flowering time	Gene Amplification, Indel	Arabis alpina gray rockcress - (species)	Intraspecific	Candidate Gene	Albani MC; Castaings L; Wötzel S ; et al. (2012) PEP1 of Arabis alpina is encoded by two overlapping genes that contribute to natural genetic variati[...]	GP00000329	FLC Q9S7Q7	Physiology	complex structural variations	Arabis alpina gray rockcress - (species)	Arabis alpina gray rockcress - (species)		FLC (=Pep1)	Arabis alpina gray rockcress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000330	FLC Q9S7Q7	Physiology	Substitution creating premature Stop (codon 158) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	2 Mutations: Cis-regulatory SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Coustham V; Li P; Strange A ; et al. (2012) Quantitative modulation of polycomb silencing underlies natural variation in vernalization. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000331	FLC Q9S7Q7	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Insertion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Michaels SD; He Y; Scortecci KC ; et al. (2003) Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...] 3 Additional References Gazzani S; Gendall AR; Lister C (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions. Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...] Liu J; He Y; Amasino R (2004) siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidops[...]	GP00000332	FLC Q9S7Q7	Physiology	TE insertion in intron 1; a region required for normal FLC regulation. The transposable element renders FLC-Ler subject to repressive chromatin modifications mediated by short interfering RNAs generated from homologous transposable elements in the genome.	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Michaels SD; He Y; Scortecci KC ; et al. (2003) Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...] 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000333	FLC Q9S7Q7	Physiology	Not identified	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000334	FLC Q9S7Q7	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000335	FLC Q9S7Q7	Physiology	GA substitution disrupting Splice Site	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Sánchez-Bermejo E; Méndez-Vigo B; Picó FX ; et al. (2012) Novel natural alleles at FLC and LVR loci account for enhanced vernalization responses in Arabidopsi[...] 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000336	FLC Q9S7Q7	Physiology	50bp deletion in 5'UTR	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Capsella rubella (species)	Intraspecific	Linkage Mapping	Guo YL; Todesco M; Hagmann J ; et al. (2012) Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella[...]	GP00000337	FLC Q9S7Q7	Physiology	Splice site mutation introducing frameshift; removing the last 35 of 198 amino acids	Capsella rubella (species)	Capsella rubella (species)		FLC (Flowering Locus C)	Capsella rubella (species)	Published - Accepted by Curator
FLM (MAF1)	Flowering time	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Warthmann N ; et al. (2005) Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for[...]	GP00000341	AGL27 Q9AT76	Physiology	Deletion of entire gene N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLM (MAF1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FMO2	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Mallott M; Hamm S; Troczka BJ ; et al. (2019) A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]	GP00002065	FMO2 Q99518	Physiology	a putatative transposon (233bp) insertion in the HAW promoter sequence just 140 bp upstream of the start codon of PxFMO2 which was absent in the ROTH promoter, the boundaries of all copies of this element were found to be defined by 34 bp imperfect terminal inverted repeats, increase the expression of the gene PxFMO2 downstream	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		FMO2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
follistatin	Limb morphology (wing dimorphism) Flight behavior (wing dimorphism)	Gene Amplification, Insertion	Acyrthosiphon pisum pea aphid - (species) D	Intraspecific	Linkage Mapping	Li B; Bickel RD; Parker BJ ; et al. (2020) A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male w[...]	GP00002138	Fs Q86NV3	Morphology Behavior	the api allele from winged males is a 120kb insertion that includes a copy of the follistatin gene	Acyrthosiphon pisum pea aphid - (species)	Acyrthosiphon pisum pea aphid - (species) D		follistatin	Acyrthosiphon pisum pea aphid - (species)	Published - Accepted by Curator	February 9, 2021 22:00
foraging	Food-search behavior	Cis-regulatory, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Osborne KA; Robichon A; Burgess E ; et al. (1997) Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. 2 Additional References Mery F; Belay AT; So AK (2007) Natural polymorphism affecting learning and memory in Drosophila. Anreiter I; Kramer JM; Sokolowski MB (2017) Epigenetic mechanisms modulate differences in Drosophila foraging behavior.	GP00000350	for Q03043	Behavior	The fors (sitter) and forR (rover) alleles differ in a SNP that lies within a predicted Mad protein-binding site in a region upstream of the pr4 transcription start site. The SNP is a C in fors and an A in forR (the latter is predicted to reduce Mad protein binding).	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		foraging	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
foraging	Food-search behavior	Unknown, Unknown	Sesamia nonagrioides Mediterranean corn borer - (species)	Intraspecific	Candidate Gene	Chardonnet F; Capdevielle-Dulac C; Chouquet B ; et al. (2014) Food searching behaviour of a Lepidoptera pest species is modulated by the foraging gene polymorphis[...]	GP00002619	for Q03043	Behavior	Association between a coding SNP in foraging gene and foraging activity. But not clear whether the causal mutation is this one.	Sesamia nonagrioides Mediterranean corn borer - (species)	Sesamia nonagrioides Mediterranean corn borer - (species)		foraging	Sesamia nonagrioides Mediterranean corn borer - (species)	Published - Accepted by Curator
foxo	Body size (wing) Starvation resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Betancourt NJ; Rajpurohit S; Durmaz E ; et al. (2021) Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster. 1 Additional References Durmaz E; Rajpurohit S; Betancourt N (2019) A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history[...]	GP00002661	foxo Q95V55	Morphology Morphology; Physiology		Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		foxo	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
FPN2	Metal tolerance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Morrissey J; Baxter IR; Lee J ; et al. (2009) The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.	GP00000354	IREG2 F4KGN5	Physiology	1bp insertion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		FPN2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pineau C; Loubet S; Lefoulon C ; et al. (2012) Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Z[...]	GP00000355	DTX43 Q9SFB0	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]	GP00000357	FRI P0DH90	Physiology	16bp deletion aa313-318 in exon 2 and premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000358	FRI P0DH90	Physiology	376 bp deletion and 31 bp insertion that delete amino acid 1-15 and at best produce a 45-aa protein N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000359	FRI P0DH90	Physiology	Del 2257-2355 in exon 3; deletion of 99 bp combined with an insertion of 61 bp N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000360	FRI P0DH90	Physiology	1bp deletion at 1487 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000361	FRI P0DH90	Physiology	1bp insertion at 766 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000362	FRI P0DH90	Physiology	Insertion 1 bp at 1454 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000363	FRI P0DH90	Physiology	Trp240* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000364	FRI P0DH90	Physiology	Glu361* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gazzani S; Gendall AR; Lister C ; et al. (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.	GP00000365	FRI P0DH90	Physiology	K232* in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000366	FRI P0DH90	Physiology	deletion; E430* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000367	FRI P0DH90	Physiology	deletion of 6 amino acids; LQLDKE422-427*	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000368	FRI P0DH90	Physiology	deletion aa 1-12	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000369	FRI P0DH90	Physiology	deletion resulting in S121* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000370	FRI P0DH90	Physiology	deletion; AF375-6* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000371	FRI P0DH90	Physiology	insertion; I490* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000372	FRI P0DH90	Physiology	insertion; T258* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000373	FRI P0DH90	Physiology	Y162* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000374	FRI P0DH90	Physiology	K170* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time Water use efficiency	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Lovell JT; Juenger TE; Michaels SD ; et al. (2013) Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation.	GP00000375	FRI P0DH90	Physiology Physiology	376 bp deletion within the promoter of the TSU-1 FRI allele	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 1 (FRL1)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000376	FRL1 Q9FFF1	Physiology	E279* in the middle of the conceptual protein sequence N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida like 1 (FRL1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 2 (FRL2)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000377	FRL2 Q9C6S2	Physiology	A132P and/or L401Q	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida like 2 (FRL2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FST/MOCS2	coloration (head feathers)	Cis-regulatory, Unknown	Erythrura gouldiae Gouldian finch - (species)	Intraspecific	Association Mapping	Toomey MB; Marques CI; Andrade P ; et al. (2018) A non-coding region near Follistatin controls head colour polymorphism in the Gouldian finch. 1 Additional References Kim KW; Jackson BC; Zhang H (2019) Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird.	GP00002125		Morphology	candidate locus is a small (approx. 70 kb) non-coding region mapping to the Z chromosome near the FST and MOCS2	Erythrura gouldiae Gouldian finch - (species)	Erythrura gouldiae Gouldian finch - (species)		FST/MOCS2	Erythrura gouldiae Gouldian finch - (species)	Published - Accepted by Curator
FTO	Body size (weight; variance)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Frayling TM; Timpson NJ; Weedon MN ; et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and[...] 4 Additional References Dina C; Meyre D; Gallina S (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Scuteri A; Sanna S; Chen WM (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-rela[...] Yang J; Loos RJ; Powell JE (2012) FTO genotype is associated with phenotypic variability of body mass index. Claussnitzer M; Dankel SN; Kim KH (2015) FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.	GP00000378	FTO Q9C0B1	Morphology; Physiology	rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor	Homo sapiens human - (species)	Homo sapiens human - (species)		FTO	Homo sapiens human - (species)	Published - Accepted by Curator
FTO	Body fat distribution (subcutaneous)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001560	FTO Q9C0B1	Physiology	A>G in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		FTO	Homo sapiens human - (species)	Published - Accepted by Curator
FUMARASE 2	Plant metabolism (fumarate/malate ratio) Plant growth (bio-mass production)	Cis-regulatory, Indel	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Riewe D; Jeon HJ; Lisec J ; et al. (2016) A naturally occurring promoter polymorphism of the Arabidopsis FUM2 gene causes expression variation[...] 1 Additional References Lisec J; Meyer RC; Steinfath M (2008) Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL an[...]	GP00001286	FUM2 Q9FI53	Physiology Physiology	2068 bp in promotor region @position -395. AND 3833bp in promotor region @position -1107	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FUMARASE 2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...]	GP00000379	FUT2 Q10981	Physiology	9.3 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 2 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...] Koda Y; Soejima M; Johnson PH (2000) An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype.	GP00000380	FUT2 Q10981	Physiology	10 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000381	FUT2 Q10981	Physiology	premature stop at codon 143: TGG>TGA N	Homo sapiens human - (species)	Homo sapiens human - (species)		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000382	FUT2 Q10981	Physiology	Ile129Phe	Homo sapiens human - (species)	Homo sapiens human - (species)		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
G protein-coupled receptor rhodopsin	Diapause	Unknown, Unknown	Daphnia magna (species)	Intraspecific	Linkage Mapping	Roulin AC; Bourgeois Y; Stiefel U ; et al. (2016) A Photoreceptor Contributes to the Natural Variation of Diapause Induction in Daphnia magna.	GP00001539	RHO P08100	Physiology	unknown	Daphnia magna (species)	Daphnia magna (species)		G protein-coupled receptor rhodopsin	Daphnia magna (species)	Published - Accepted by Curator
GATA-binding protein 2 (GATA2)	Hematopoiesis (blood basophil count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001610	GATA2 P23769	Physiology	G>A at the associated SNP. Another variant (rs6782812) in a pleiotropic myeloid enhancer near GATA2 reduced enhancer activity by 69%	Homo sapiens human - (species)	Homo sapiens human - (species)		GATA-binding protein 2 (GATA2)	Homo sapiens human - (species)	Published - Accepted by Curator
GDF5	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sanna S; Jackson AU; Nagaraja R ; et al. (2008) Common variants in the GDF5-UQCC region are associated with variation in human height. 1 Additional References Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000387	GDF5 P43026	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		GDF5	Homo sapiens human - (species)	Published - Accepted by Curator
GDF6	Dermal bone size (armor plates)	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Indjeian VB; Kingman GA; Jones FC ; et al. (2016) Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.	GP00000388	GDF6 Q6KF10	Morphology	gain of a flank enhancer activity involving a complex repeat region; 1.2kb L2 LINE insertion; 18 small indels and 89 SNPs - the LINE insertion is required but not sufficient, to produce increased flank expression	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		GDF6	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Ge-1	Pathogen resistance (sigma virus)	Coding, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Cao C; Magwire MM; Bayer F ; et al. (2016) A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rh[...]	GP00001993	Ge-1 Q9VKK1	Physiology	78bp deletion ( 2L:11097925 ..11098002 in both Release 5 and Release 6 coordinates) in the fifth exon of Ge-1 which reduces the length of the serine-rich linker region by 26 amino acid residues	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Ge-1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GHSR	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000394	GHSR Q92847	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		GHSR	Homo sapiens human - (species)	Published - Accepted by Curator
GIBBERELLIC ACID REQUIRING 1 (GA1)	Flower morphology	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Brock MT; Kover PX; Weinig C (2012) Natural variation in GA1 associates with floral morphology in Arabidopsis thaliana.	GP00000395	GA1 Q38802	Morphology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GIBBERELLIC ACID REQUIRING 1 (GA1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome (leaves)	Unknown, Unknown	Arabidopsis (genus)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Kivimäki M; Kärkkäinen K; Gaudeul M (2007) Gene, phenotype and function: GLABROUS1 and resistance to herbivory in natural populations of Arabid[...]	GP00000398	GL1 P27900	Morphology	unknown	Arabidopsis (genus)	Arabidopsis (genus)		GLABROUS1	Arabidopsis (genus)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Gene Loss, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001238	GL1 P27900	Morphology	gene loss: -4.7KB at position -948bp N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001239	GL1 P27900	Morphology	S92F	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001240	GL1 P27900	Morphology	+1bp at position 352 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001241	GL1 P27900	Morphology	-1bp at position 203 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001242	GL1 P27900	Morphology	high frequency pattern of polymorphism identified in the third exon and 3' flank	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
glb-5	CO2 avoidance Aggregation behavior	Coding, Indel N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	McGrath PT; Rockman MV; Zimmer M ; et al. (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] 2 Additional References Bendesky A; Pitts J; Rockman MV (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...] Persson A; Gross E; Laurent P (2009) Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.	GP00000399	glb-5 A3RMS5	Behavior Behavior	765bp insertion/duplication resulting in a truncation of the last 179 amino acids of the protein and the inclusion of 40 different residues N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		glb-5	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLC-1	Xenobiotic resistance (antihelmintics)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Ghosh R; Andersen EC; Shapiro JA ; et al. (2012) Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.	GP00000400	glc-1 G5EBR3	Physiology	4aa deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		GLC-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLO(T)	Flower morphology (anther elevation)	Coding, Insertion N	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001393	GLO Q03378	Morphology	A 2.5 kb retrotransposon in exon 2 severely truncates the protein N	Primula vulgaris (species)	Primula vulgaris (species) D		GLO(T)	Primula vulgaris (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000401	G6PD P11413	Physiology	Ser188Phe C>T	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Louicharoen C; Patin E; Paul R ; et al. (2009) Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.	GP00000402	G6PD P11413	Physiology	Ser163Gly	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000403	G6PD P11413	Physiology	Val68Met G>A at nucleotide position 376 in exon 5 - OMIM code +305900.0002	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-dependent insulinotropic polypeptide	Glycemia Adipolysis rate	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Chang CL; Cai JJ; Lo C ; et al. (2011) Adaptive selection of an incretin gene in Eurasian populations.	GP00000404	GIP P09681	Physiology Physiology	Ser103Gly	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-dependent insulinotropic polypeptide	Homo sapiens human - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; abamectin)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Dermauw W; Ilias A; Riga M ; et al. (2012) The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: implications for acaricide[...]	GP00002601	GluClalpha Q94900	Physiology	G326E inTu_GluCl3	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		glutamate-gated chloride channel (GluCl)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; nodulisporic acid)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Kane NS; Hirschberg B; Qian S ; et al. (2000) Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasit[...]	GP00002602	GluClalpha Q94900	Physiology	P299S	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		glutamate-gated chloride channel (GluCl)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; ivermectin)	Coding, SNP	Cooperia oncophora (species) D	Intraspecific	Candidate Gene	Njue AI; Hayashi J; Kinne L ; et al. (2004) Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits [...]	GP00002603	GluClalpha Q94900	Physiology	E114G V235A L256F in the GluCla3 ortholog and V60A R101Hin the GluClb ortholog.	Cooperia oncophora (species)	Cooperia oncophora (species) D		glutamate-gated chloride channel (GluCl)	Cooperia oncophora (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; ivermectin)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Kwon DH; Yoon KS; Clark JM ; et al. (2010) A point mutation in a glutamate-gated chloride channel confers abamectin resistance in the two-spott[...] 1 Additional References Dermauw W; Ilias A; Riga M (2012) The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: implications for acaricide[...]	GP00002604	GluClalpha Q94900	Physiology	G323D in the highly conserved TM2 region of Tu_GluCl	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		glutamate-gated chloride channel (GluCl)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; abamectin)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang X; Wang R; Yang Y ; et al. (2016) A point mutation in the glutamate-gated chloride channel of Plutella xylostella is associated with r[...]	GP00002634	GluClalpha Q94900	Physiology	A309V	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		glutamate-gated chloride channel (GluCl)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
glycerol-3-phosphate dehydrogenase (Gpdh)	Enzymatic activity	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Bewley Glenn C (1981 ) Genetic control of the developmental program of L‐glycerol‐3‐phosphate dehydrogenase isozymes in Dro[...]	GP00001992	Gpdh P13706	Physiology	Exact causal mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		glycerol-3-phosphate dehydrogenase (Gpdh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
glycerol-3-phosphate dehydrogenase (Gpdh)	Enzymatic activity	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Wilanowski TM; Gibson JB; Symonds JE (1995) Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila [...]	GP00001998	Gpdh P13706	Physiology	insertion of a 8kb blood retrotransposon in the 3' region of the Gpdh gene 66bp downstream of the stop codon. This mutation induces a GPDH isozyme-GPDH-4-and alters the pattern of expression of the three normal isozymes-GPDH-1 to GPDH-3.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		glycerol-3-phosphate dehydrogenase (Gpdh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Glycophorin GYPA-GYPB-GYPE cluster	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	; Band G; Rockett KA ; et al. (2015) A novel locus of resistance to severe malaria in a region of ancient balancing selection.	GP00000406	GYPA P02724	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		Glycophorin GYPA-GYPB-GYPE cluster	Homo sapiens human - (species)	Published - Accepted by Curator
GNBP1	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sackton TB; Lazzaro BP; Clark AG (2010) Genotype and gene expression associations with immune function in Drosophila.	GP00000408	GNBP1 Q9NHB0	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		GNBP1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GNBP2	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sackton TB; Lazzaro BP; Clark AG (2010) Genotype and gene expression associations with immune function in Drosophila.	GP00000409	GNBP2 Q9VVR4	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		GNBP2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
goldentouch	Coloration	Cis-regulatory, Insertion	Amphilophus citrinellus Midas cichlid - (species)	Intraspecific	Association Mapping	Kratochwil CF; Kautt AF; Nater A ; et al. (2022) An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid[...]	GP00002362		Morphology	"Using a new haplotype-resolved long-read assembly we discover an 8.2 kb, transposon-derived inverted repeat in an intron of an undescribed gene, which we term goldentouch in reference to the Greek myth of King Midas. The gene goldentouch is differentially expressed between morphs, presumably due to structural implications of inverted repeats in both DNA and/or RNA (cruciform and hairpin formation). The near-perfect association of the insertion with the phenotype across independent populations suggests that it likely underlies this trans-specific, stable polymorphism."	Amphilophus citrinellus Midas cichlid - (species)	Amphilophus citrinellus Midas cichlid - (species)		goldentouch	Amphilophus citrinellus Midas cichlid - (species)	Published - Accepted by Curator
GPR133	Body size (height; male-limited)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tönjes A; Koriath M; Schleinitz D ; et al. (2009) Genetic variation in GPR133 is associated with height: genome wide association study in the self-con[...]	GP00000412	ADGRD1 Q6QNK2	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		GPR133	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Insertion	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001669	GPRC6A Q5T6X5	Physiology	insertion of KL (6 bp) resulting in sequence KGKKLY in the third intracellular loop (ICL3) with surface expression and function greatly reduced	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Deletion	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001670	GPRC6A Q5T6X5	Physiology	KGRKLP>KGRK-Y in the third intracellular loop (ICL3) with surface expression and function greatly reduced	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001671	GPRC6A Q5T6X5	Physiology	KGRKLP>KGK--Y in the third intracellular loop (ICL3) responsible for the intracellular retention and lack of function N	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001672	GPRC6A Q5T6X5	Physiology	C>T (aa57) located in the first exon resulting in a premature Stop-codon and non-functional protein N	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
Gr5a	Taste sensitivity (sugar; trehalose)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Ueno K; Ohta M; Morita H ; et al. (2001) Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory rec[...] 2 Additional References Tanimura Teiichi; Isono Kunio; Takamura Tsuguhiko (1982 ) Genetic dimorphism in the taste sensitivity to trehalose inDrosophila melanogaster Inomata N; Goto H; Itoh M (2004) A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sen[...]	GP00001997	Gr5a Q9W497	Physiology	Nucleotide change: A5681571G - Amino acid change: T218A	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Gr5a	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GRAMD3	Body fat distribution (visceral)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001557	GRAMD2B Q96HH9	Physiology	A>C in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		GRAMD3	Homo sapiens human - (species)	Published - Accepted by Curator
Growth Hormone Receptor (GHR)	Body size (height)	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000415	GHR P10912	Morphology	Arg61* N	Homo sapiens human - (species)	Homo sapiens human - (species)		Growth Hormone Receptor (GHR)	Homo sapiens human - (species)	Published - Accepted by Curator
GSDMB	Body fat distribution (subcutaneous)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001556	GSDMB Q8TAX9	Physiology	T>C in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		GSDMB	Homo sapiens human - (species)	Published - Accepted by Curator
GSS (glutathione synthetase)	Coloration (skin)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Liu F; Visser M; Duffy DL ; et al. (2015) Genetics of skin color variation in Europeans: genome-wide association studies with functional follo[...]	GP00001362	GSS P48637	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		GSS (glutathione synthetase)	Homo sapiens human - (species)	Published - Accepted by Curator
GSS (glutathione synthetase)	Xenobiotic resistance (arsenic)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits. 1 Additional References Ortiz JG; Opoka R; Kane D (2009) Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for[...]	GP00002115	Gss2 Q86B44	Physiology	tandem duplication creating the Gss1/Gss2 gene pair. Associated with increased expression of Gss1.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		GSS (glutathione synthetase)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GST	Xenobiotic resistance (pyrethroid)	Gene Amplification, Insertion	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Vontas JG; Small GJ; Nikou DC ; et al. (2002) Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved [...]	GP00002643	GstD1 P20432	Physiology	nlgst1-1 is overexpressed in resistant insects. Southern analysis of genomic DNA from the resistant and susceptible strains indicated that GST-based insecticide resistance may be associated with gene amplification in N. lugens.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		GST	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Anopheles funestus African malaria mosquito - (species)	Intraspecific	Candidate Gene	Riveron JM; Yunta C; Ibrahim SS ; et al. (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002455	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species)		GSTe	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera litura (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002456	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera litura (species)	Spodoptera litura (species)		GSTe	Spodoptera litura (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera frugiperda fall armyworm - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002457	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species)		GSTe	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera exigua beet armyworm - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002458	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species)		GSTe	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera littoralis African cotton leafworm - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002459	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera littoralis African cotton leafworm - (species)	Spodoptera littoralis African cotton leafworm - (species)		GSTe	Spodoptera littoralis African cotton leafworm - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Anopheles funestus African malaria mosquito - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002460	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species)		GSTe	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
GSTE1-E10 cluster	Xenobiotic resistance (drug)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kislukhin G; King EG; Walters KN ; et al. (2013) The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.	GP00000419	GstE1 Q7KK90	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		GSTE1-E10 cluster	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000426	ABCA2 A0A0S0G7V0	Physiology	Pro53* (161T>A) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...] 2 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000427	ABCA2 A0A0S0G7V0	Physiology	10kb deletion N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000428	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000429	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000430	ABCA2 A0A0S0G7V0	Physiology	Insertion of an incomplete RNA transposon (1498bp) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000431	ABCA2 A0A0S0G7V0	Physiology	Insertion of a DNA transposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000432	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000433	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
HAC1 (=ATQ1)	Xenobiotic resistance (soil contamination; arsenate)	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sánchez-Bermejo E; Castrillo G; del Llano B ; et al. (2014) Natural variation in arsenate tolerance identifies an arsenate reductase in Arabidopsis thaliana. 1 Additional References Chao DY; Chen Y; Chen J (2014) Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]	GP00000434	HAC1 Q9C5X9	Physiology	Coding variation and differential gene expression in roots	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		HAC1 (=ATQ1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HAC1 (=ATQ1)	Xenobiotic resistance (soil contamination; arsenate)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Chen Y; Chen J ; et al. (2014) Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]	GP00000435	HAC1 Q9C5X9	Physiology	1bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		HAC1 (=ATQ1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
hairy (h)	Bristle number (thorax)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Robin C; Lyman RF; Long AD ; et al. (2002) hairy: A quantitative trait locus for drosophila sensory bristle number.	GP00000436	h P14003	Morphology	unknown; complex promoter indel variation shows high-association	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		hairy (h)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
HBS1L-MYB	Hematopoiesis (mean blood corpuscular hemoglobin)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001607	HBS1L Q9Y450	Physiology	T>C at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants	Homo sapiens human - (species)	Homo sapiens human - (species)		HBS1L-MYB	Homo sapiens human - (species)	Published - Accepted by Curator
HBS1L-MYB	Hematopoiesis (mean blood corpuscular hemoglobin)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001608	HBS1L Q9Y450	Physiology	A>G at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants	Homo sapiens human - (species)	Homo sapiens human - (species)		HBS1L-MYB	Homo sapiens human - (species)	Published - Accepted by Curator
HBS1L-MYB	Hematopoiesis (red blood cell count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001609	HBS1L Q9Y450	Physiology	C>T at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants	Homo sapiens human - (species)	Homo sapiens human - (species)		HBS1L-MYB	Homo sapiens human - (species)	Published - Accepted by Curator
HBS1L-MYB	Hematopoiesis (blood platelet count)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001614	HBS1L Q9Y450	Physiology	T>C at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		HBS1L-MYB	Homo sapiens human - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000443	HMA3 P0CW78	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000444	HMA3 P0CW78	Physiology	1-bp deletion resulting in a premature stop codon resulting in hypofunctional transporter. This is a high-frequency allele; suggesting the hyper-functional alleles are only selected in Cd-rich soils N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Gene Amplification, Complex Change	Noccaea caerulescens (species)	Intraspecific	Candidate Gene	Ueno D; Milner MJ; Yamaji N ; et al. (2011) Elevated expression of TcHMA3 plays a key role in the extreme Cd tolerance in a Cd-hyperaccumulating[...]	GP00000446	HMA3 P0CW78	Physiology	Copy number Variant	Noccaea caerulescens (species)	Noccaea caerulescens (species)		heavy metal atpase3 (HMA3)	Noccaea caerulescens (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000450	HMA5 Q9SH30	Physiology	P626L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000451	HMA5 Q9SH30	Physiology	N923T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000452	hecw-1 G5EEJ0	Behavior	Y322C	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000453	hecw-1 G5EEJ0	Behavior	Q325P	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
hemoglobin; HBA-T1 and T2 paralogues	Hypoxia response	5 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Sabatino SJ; Hoffmann FG ; et al. (2007) The molecular basis of high-altitude adaptation in deer mice. 2 Additional References Storz JF; Kelly JK (2008) Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights [...] Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000456	HBA1 P69905	Physiology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		hemoglobin; HBA-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas cyanoptera cinnamon teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000457	HBA1 P69905	Physiology	Asn9Ser	Anas cyanoptera cinnamon teal - (species)	Anas cyanoptera cinnamon teal - (species) D		hemoglobin; HBA2	Anas cyanoptera cinnamon teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000458	HBA1 P69905	Physiology	Ala77Thr	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000459	HBAD P02001	Physiology	Ser130Phe	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000463	HBA1 P69905	Physiology	Ala5Thr	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBA2	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Merganetta armata (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000464	HBA1 P69905	Physiology	Ala77Thr	Merganetta armata (species)	Merganetta armata (species) D		hemoglobin; HBA2	Merganetta armata (species)	Published - Accepted by Curator
hemoglobin; HBB	Pathogen resistance (Plasmodium; malaria parasite)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Jallow M; Teo YY; Small KS ; et al. (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa.	GP00000466	HBB P68871	Physiology	Glu6Val	Homo sapiens human - (species)	Homo sapiens human - (species) D		hemoglobin; HBB	Homo sapiens human - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000467	HBB P68871	Physiology	2 mutations	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBB	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas georgica yellow-billed pintail - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000468	HBB P68871	Physiology	2 mutations	Anas georgica yellow-billed pintail - (species)	Anas georgica yellow-billed pintail - (species) D		hemoglobin; HBB	Anas georgica yellow-billed pintail - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000472	HBB P68871	Physiology	Asp94Glu	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB-T1 and T2 paralogues	Hypoxia response	4 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Runck AM; Sabatino SJ ; et al. (2009) Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer [...] 1 Additional References Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000476	HBB P68871	Physiology	4 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		hemoglobin; HBB-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
high expression of osmotically responsive genes 2	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001435	SAL1 Q42546	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		high expression of osmotically responsive genes 2	Arabidopsis arenosa (species)	Published - Accepted by Curator
HLA-DQA1	Histocompatibility	Cis-regulatory, Unknown	Papio baboons - (genus)	Intraspecific	Candidate Gene	Loisel DA; Rockman MV; Wray GA ; et al. (2006) Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region.	GP00000478	HLA-DQA1 P01909	Physiology	Promoter variation	Papio baboons - (genus)	Papio baboons - (genus)		HLA-DQA1	Papio baboons - (genus)	Published - Accepted by Curator
HLA-DRB1	Pathogen resistance (typhoid fever)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Dunstan SJ; Hue NT; Han B ; et al. (2014) Variation at HLA-DRB1 is associated with resistance to enteric fever.	GP00000479	HLA-DRB1 Q30167	Physiology	uncharacterized	Homo sapiens human - (species)	Homo sapiens human - (species)		HLA-DRB1	Homo sapiens human - (species)	Published - Accepted by Curator
HMGA2	Body size (height; bone mineral density)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Weedon MN; Lettre G; Freathy RM ; et al. (2007) A common variant of HMGA2 is associated with adult and childhood height in the general population. 3 Additional References Yang TL; Guo Y; Zhang LS (2010) HMGA2 is confirmed to be associated with human adult height. Kuipers A; Zhang Y; Cauley JA (2009) Association of a high mobility group gene (HMGA2) variant with bone mineral density. Horikoshi M; Yaghootkar H; Mook-Kanamori DO (2013) New loci associated with birth weight identify genetic links between intrauterine growth[...]	GP00000486	HMGA2 P52926	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		HMGA2	Homo sapiens human - (species)	Published - Accepted by Curator
HP1D2	Sex determination (sex ratio distortion)	Coding, Deletion N	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Helleu Q; Gérard PR; Dubruille R ; et al. (2016) Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.	GP00001467	HP1D2 B4R6K0	Physiology	deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N	Drosophila simulans (species)	Drosophila simulans (species) D		HP1D2	Drosophila simulans (species)	Published - Accepted by Curator
Hps4	Coloration (albinism)	Coding, Deletion N	Ictalurus punctatus channel catfish - (species) D	Intraspecific	Association Mapping	Li Y; Geng X; Bao L ; et al. (2017) A deletion in the Hermansky-Pudlak syndrome 4 (Hps4) gene appears to be responsible for albinism in [...]	GP00002122	Hps4 Q99KG7	Morphology	A 99‐bp deletion was identified spanning intron 2 and exon 3 junction of the Hps4 gene N	Ictalurus punctatus channel catfish - (species)	Ictalurus punctatus channel catfish - (species) D		Hps4	Ictalurus punctatus channel catfish - (species)	Published - Accepted by Curator
hsp70Ba	Temperature tolerance	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Lerman DN; Michalak P; Helin AB ; et al. (2003) Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]	GP00002004	Hsp70Ba Q8INI8	Physiology	A 1447 bp fragment corresponding to the 39 end of a jockey element is inserted 107 bps upstream of the hsp70Ba transcription start site in the T strain. The insertion intervenes between HSEs 2 and 3; displacing HSEs 3 and 4 as well as three GAGA elements.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		hsp70Ba	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
hsp70Ba	Temperature tolerance	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Lerman DN; Michalak P; Helin AB ; et al. (2003) Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]	GP00002005	Hsp70Ba Q8INI8	Physiology	Insertion of a 1222bp non-autonomous P-element at position -184 relative to the Hsp70Ba transcription start site. The P-element intervenes between the second and third heat shock response elements (HSEs).	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		hsp70Ba	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
hsp70Ba	Temperature tolerance	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Lerman DN; Michalak P; Helin AB ; et al. (2003) Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]	GP00002006	Hsp70Ba Q8INI8	Physiology	A non-autonomous 1383bp P-element is inserted 97bp upstream of the Hsp70Ba transcription start site. The P-element intervenes between the second and third heat shock response elements (HSEs).	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		hsp70Ba	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
HSP90	Developmental time	Unknown, Insertion	Locusta migratoria migratory locust - (species) D	Intraspecific	Candidate Gene	Chen B; Zhang B; Xu L ; et al. (2017) Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation.	GP00002437	daf-21 Q18688	Physiology	an Lm1 SINE insertion in the third exon of the Hsp90 gene produces an alternative splicing form associated with faster development and higher developmental synchrony. Found by scanning Lm1 insertions in natural locust populations.	Locusta migratoria migratory locust - (species)	Locusta migratoria migratory locust - (species) D		HSP90	Locusta migratoria migratory locust - (species)	Published - Accepted by Curator
HUA2	Flowering time Shoot morphology	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Wang Q; Sajja U; Rosloski S ; et al. (2007) HUA2 caused natural variation in shoot morphology of A. thaliana.	GP00000491	HUA2 Q9XER9	Physiology Morphology	K525E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HUA2	Flowering time Coloration (temperature-dependent)	Coding, Unknown N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ilk N; Ding J; Ihnatowicz A ; et al. (2015) Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...] 1 Additional References Doyle MR; Bizzell CM; Keller MR (2005) HUA2 is required for the expression of floral repressors in Arabidopsis thaliana.	GP00001230	HUA2 Q9XER9	Physiology Morphology	Premature stop codon resulting in truncation of 290 C-terminal amino-acids (hua-2-5 Ler allele) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Human Leukocyte Antigen-B (HLA-B)	Pathogen resistance (HIV control)	5 Mutations: Coding SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	; Pereyra F; Jia X ; et al. (2010) The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.	GP00000492	HLA-B P01889	Physiology	5 mutations	Homo sapiens human - (species)	Homo sapiens human - (species)		Human Leukocyte Antigen-B (HLA-B)	Homo sapiens human - (species)	Published - Accepted by Curator
I Kappa B Kinase Interacting Protein (IKBIP)	Lifespan	Unknown, Unknown	Nothobranchius furzeri turquoise killifish - (species)	Intraspecific	Association Mapping	Reichwald K; Petzold A; Koch P ; et al. (2015) Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.	GP00001678	IKBIP Q70UQ0	Physiology	Under positive selection; down regulated in aging skin	Nothobranchius furzeri turquoise killifish - (species)	Nothobranchius furzeri turquoise killifish - (species)		I Kappa B Kinase Interacting Protein (IKBIP)	Nothobranchius furzeri turquoise killifish - (species)	Published - Accepted by Curator
ICARUS1	Plant growth (leaf morphology ; temperature-dependent) Hypersensitive to DNA damage	2 Mutations: Coding N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Zhu W; Ausin I; Seleznev A ; et al. (2015) Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at[...]	GP00002066	ICA1 A0A0F7PXK5	Physiology Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		ICARUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
IGK	Pathogen resistance	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001382	IGKV1-5 P01602	Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		IGK	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
IIL1	Plant growth (pleiotropic growth abnormalities)	Cis-regulatory, Insertion	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sureshkumar S; Todesco M; Schneeberger K ; et al. (2009) A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana. 1 Additional References Tabib A; Vishwanathan S; Seleznev A (2016) A Polynucleotide Repeat Expansion Causing Temperature-Sensitivity Persists in Wild Irish Accessions [...]	GP00001229	IIL1 Q94AR8	Morphology	expansion of a GAA/TTC trinucleotide repeat in the third intron	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		IIL1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
IL4	Immune response	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Linkage Mapping	Rockman MV; Hahn MW; Soranzo N ; et al. (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression.	GP00000497	IL4 P05112	Physiology	_524T promoter single base-pair substitution affecting binding of the NFAT transcription factor	Homo sapiens human - (species)	Homo sapiens human - (species)		IL4	Homo sapiens human - (species)	Published - Accepted by Curator
IME1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00000498	IME1 P21190	Physiology	L325M and/or 1bp synonymous substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		IME1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Immune deficiency	Pathogen resistance	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sceurman BK; Clark AG (2004) Genetic basis of natural variation in D. melanogaster antibacterial immunity.	GP00000499	imd Q9NHG0	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Immune deficiency	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Inhibitor of DNA binding 3 (id3)	Lifespan	Unknown, Unknown	Nothobranchius furzeri turquoise killifish - (species) D	Intraspecific	Association Mapping	Reichwald K; Petzold A; Koch P ; et al. (2015) Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.	GP00001676	ID3 Q02535	Physiology	Signature of selection for id3. upregulated during aging in brain and skin. A radical substitution of a non-polar by a charged aa (A>Q) followed by a 2-aa deletion in the C-terminus	Nothobranchius furzeri turquoise killifish - (species)	Nothobranchius furzeri turquoise killifish - (species) D		Inhibitor of DNA binding 3 (id3)	Nothobranchius furzeri turquoise killifish - (species)	Published - Accepted by Curator
InR	Fertility Developmental time Body size Stress response Lifespan	Coding, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Paaby AB; Bergland AO; Behrman EL ; et al. (2014) A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-[...] 1 Additional References Paaby AB; Blacket MJ; Hoffmann AA (2010) Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independ[...]	GP00002663	InR P09208	Morphology Morphology; Physiology Physiology Physiology Physiology	Deletion of 9 nucleotides in the first exon. The two alleles differ by presence/absence of the three amino acids QHH.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		InR	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Insulin-like growth factor receptor 1 (IGF1R)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000503	IGF1R P08069	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		Insulin-like growth factor receptor 1 (IGF1R)	Homo sapiens human - (species)	Published - Accepted by Curator
IRF4	Coloration (skin)	Cis-regulatory, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Praetorius C; Grill C; Stacey SN ; et al. (2013) A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway[...] 1 Additional References Visser M; Palstra RJ; Kayser M (2015) Allele-specific transcriptional regulation of IRF4 in melanocytes is mediated by chromatin looping o[...]	GP00001364	IRF4 Q15306	Morphology	a C>T substitution in intron4 located within an enhancer	Homo sapiens human - (species)	Homo sapiens human - (species) D		IRF4	Homo sapiens human - (species)	Published - Accepted by Curator
JAK2	Hematopoiesis (blood platelet count)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001613	JAK2 O60674	Physiology	G>A at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		JAK2	Homo sapiens human - (species)	Published - Accepted by Curator
JAZF1	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Johansson A; Marroni F; Hayward C ; et al. (2009) Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide assoc[...] 1 Additional References Soranzo N; Rivadeneira F; Chinappen-Horsley U (2009) Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations wi[...]	GP00000507	JAZF1 Q86VZ6	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		JAZF1	Homo sapiens human - (species)	Published - Accepted by Curator
Jheh1-Jheh2-Jheh3 complex	Oxidative stress resistance	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	González J; Macpherson JM; Petrov DA (2009) A recent adaptive transposable element insertion near highly conserved developmental loci in Drosoph[...] 1 Additional References Guio L; González J (2015) The dominance effect of the adaptive transposable element insertion Bari-Jheh depends on the genetic[...]	GP00001782	JHEH Q6U6J0	Physiology	insertion of a transposable element Bari-Jheh associated with downregulation of Juvenile hormone epoxy hydroxylase 2 (Jheh2) and Jheh3 in nonstress conditions and with upregulation of Jheh1 and Jheh2 and downregulation of Jheh3 under oxidative stress conditions	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Jheh1-Jheh2-Jheh3 complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
JMJD1C	Hematopoiesis (mean blood platelet volume)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001606	JMJD1C Q15652	Physiology	T>A at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		JMJD1C	Homo sapiens human - (species)	Published - Accepted by Curator
K+ uptake permease 9	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001430	POT9 O49423	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		K+ uptake permease 9	Arabidopsis arenosa (species)	Published - Accepted by Curator
KCNH4 - uncertain	Freshwater adaptation	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Association Mapping	Jones FC; Grabherr MG; Chan YF ; et al. (2012) The genomic basis of adaptive evolution in threespine sticklebacks.	GP00000510	KCNH4 Q9UQ05	Physiology	Large Inversion resulting in alternative transcripts	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		KCNH4 - uncertain	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
KCNQ1	Body size (height)	Unknown, Epigenetic Change	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000511	KCNQ1 P51787	Morphology	unknown causative change in an imprinted region - consistent with maternal inheritance detected by the association	Homo sapiens human - (species)	Homo sapiens human - (species)		KCNQ1	Homo sapiens human - (species)	Published - Accepted by Curator
KCS18	Oil composition	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jasinski S; Lécureuil A; Miquel M ; et al. (2012) Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]	GP00000512	FAE1 Q38860	Physiology	L407V N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		KCS18	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001510	PF3D7_1343700 Q8IDQ2	Physiology	D353Y affecting the BTB/POZ domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001511	PF3D7_1343700 Q8IDQ2	Physiology	P441L affecting the BTB/POZ domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001512	PF3D7_1343700 Q8IDQ2	Physiology	F446I affecting the encoded propeller and BTB/POZ domains	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001513	PF3D7_1343700 Q8IDQ2	Physiology	G449A affecting the encoded propeller and BTB/POZ domains	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001514	PF3D7_1343700 Q8IDQ2	Physiology	N458Y affecting the encoded propeller and BTB/POZ domains	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001515	PF3D7_1343700 Q8IDQ2	Physiology	A481V affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001516	PF3D7_1343700 Q8IDQ2	Physiology	p.Tyr493His affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001517	PF3D7_1343700 Q8IDQ2	Physiology	N525D affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001518	PF3D7_1343700 Q8IDQ2	Physiology	N537I affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001519	PF3D7_1343700 Q8IDQ2	Physiology	p.Arg539Thr affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001520	PF3D7_1343700 Q8IDQ2	Physiology	p.Ile543Thr affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001521	PF3D7_1343700 Q8IDQ2	Physiology	p.Pro553Leu affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001522	PF3D7_1343700 Q8IDQ2	Physiology	R561H affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001523	PF3D7_1343700 Q8IDQ2	Physiology	V568G affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001524	PF3D7_1343700 Q8IDQ2	Physiology	P574L affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001525	PF3D7_1343700 Q8IDQ2	Physiology	p.Cys580Tyr affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001526	PF3D7_1343700 Q8IDQ2	Physiology	D584V affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001527	PF3D7_1343700 Q8IDQ2	Physiology	F673I affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001528	PF3D7_1343700 Q8IDQ2	Physiology	A675V affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001529	PF3D7_1343700 Q8IDQ2	Physiology	H719N affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13 (K13)	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Candidate Gene	Straimer J; Gnädig NF; Witkowski B ; et al. (2015) Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clin[...]	GP00001388	PF13_0238 A0A077LQB4	Physiology	M476I	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13 (K13)	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kin of irre (kire)	Xenobiotic resistance (methylmercury ; development)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Montgomery SL; Vorojeikina D; Huang W ; et al. (2014) Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myo[...]	GP00001398	kirre Q9N9Y9	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		kin of irre (kire)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Kit ligand	Coloration (coat)	Cis-regulatory, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Miller CT; Beleza S; Pollen AA ; et al. (2007) cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...] 1 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans.	GP00000522	KITLG P21583	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		Kit ligand	Homo sapiens human - (species)	Published - Accepted by Curator
Kit ligand	Coloration (gills; ventrum)	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Linkage Mapping	Miller CT; Beleza S; Pollen AA ; et al. (2007) cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...]	GP00000523	KITLG P21583	Morphology	Not identified	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		Kit ligand	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Kit ligand	Coloration (hair)	Cis-regulatory, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Guenther CA; Tasic B; Luo L ; et al. (2014) A molecular basis for classic blond hair color in Europeans.	GP00001349	KITLG P21583	Morphology	A>G SNP(rs12821256) 350kb upstream of transcription start	Homo sapiens human - (species)	Homo sapiens human - (species) D		Kit ligand	Homo sapiens human - (species)	Published - Accepted by Curator
KUK	Root development	2 Mutations: Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Meijón M; Satbhai SB; Tsuchimatsu T ; et al. (2014) Genome-wide association study using cellular traits identifies a new regulator of root development i[...]	GP00001233	At1g60370 O80758	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		KUK	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
L6	Pathogen resistance	Coding, Insertion N	Linum usitatissimum flax - (species)	Intraspecific	Linkage Mapping	Lawrence GJ; Finnegan EJ; Ayliffe MA ; et al. (1995) The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 an[...]	GP00000528	L6 Q40253	Physiology	Truncated protein due to insertion of a transposable element. Reversion to resistance among descendants of mutant X75 was associated with excision of the newly transposable element Ac. N	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species)		L6	Linum usitatissimum flax - (species)	Published - Accepted by Curator
LACCASE 8	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001436	LAC8 Q9LFD2	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		LACCASE 8	Arabidopsis arenosa (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Linkage Mapping	Enattah NS; Sahi T; Savilahti E ; et al. (2002) Identification of a variant associated with adult-type hypolactasia. 1 Additional References Tishkoff SA; Reed FA; Ranciaro A (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000529	LCT P09848	Physiology	C-13910T	Homo sapiens human - (species)	Homo sapiens human - (species)		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000530	LCT P09848	Physiology	C-13907G	Homo sapiens human - (species)	Homo sapiens human - (species)		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000531	LCT P09848	Physiology	T-13915G	Homo sapiens human - (species)	Homo sapiens human - (species) D		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe. 1 Additional References Breton G; Schlebusch CM; Lombard M (2014) Lactase persistence alleles reveal partial East African ancestry of southern African Khoe pastoralis[...]	GP00000532	LCT P09848	Physiology	G14010C ; In Khoe Pastoralist group lactase persistence (LP)-regulatory region 2 SNPs with greatest frequencies 13910C>T and 14010G>C	Homo sapiens human - (species)	Homo sapiens human - (species)		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Jones BL; Raga TO; Liebert A ; et al. (2013) Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep. 1 Additional References Liebert A; Jones BL; Danielsen ET (2016) In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Differ[...]	GP00001714	LCT P09848	Physiology	T14009G (rs869051967) (ss 820486563)	Homo sapiens human - (species)	Homo sapiens human - (species) D		lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactate dehydrogenase-B (Ldh-B)	Stress response	Cis-regulatory, Unknown	Fundulus heteroclitus mummichog - (species)	Intraspecific	Linkage Mapping	Schulte PM; Glemet HC; Fiebig AA ; et al. (2000) Adaptive variation in lactate dehydrogenase-B gene expression: role of a stress-responsive regulator[...]	GP00000533	ldhb P20373	Physiology	unknown - candidate 1 bp change in southern populatin generates mammary tumor virus glucocorticoid responsive element	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species)		lactate dehydrogenase-B (Ldh-B)	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
Latexin (Lxn)	Stem cell number (hematopoietic precursors)	Cis-regulatory, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Liang Y; Jansen M; Aronow B ; et al. (2007) The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in[...]	GP00000534	Lxn P70202	Morphology	Not identified	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Latexin (Lxn)	Mus musculus house mouse - (species)	Published - Accepted by Curator
LCORL	Body size	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Horikoshi M; Yaghootkar H; Mook-Kanamori DO ; et al. (2013) New loci associated with birth weight identify genetic links between intrauterine growth[...]	GP00000537	LCORL Q8N3X6	Morphology	Not identified	Homo sapiens human - (species)	Homo sapiens human - (species)		LCORL	Homo sapiens human - (species)	Published - Accepted by Curator
Ldia2 - Diaphanous-related formin	Shell chirality (coiling)	Coding, Deletion N	Lymnaea stagnalis great pond snail - (species) D	Intraspecific	Association Mapping	Davison A; McDowell GS; Holden JM ; et al. (2016) Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.	GP00000538	DIAPH1 O60610	Morphology	1bp deletion resulting in frame-shift (pseudogenization) N	Lymnaea stagnalis great pond snail - (species)	Lymnaea stagnalis great pond snail - (species) D		Ldia2 - Diaphanous-related formin	Lymnaea stagnalis great pond snail - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Cis-regulatory, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002655	lectin-24A Q9VQU4	Physiology	A cis-regulatory polymorphism in the gene Lectin-24A abolishes expression after infection and strongly reduces survival. 21bp indel (c.-171_-151del)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002656	lectin-24A Q9VQU4	Physiology	a 165bp deletion in the protein coding sequence that results in a shift in the reading frame and a premature stop codon (p.Phe217_Glu273del*) N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, SNP N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002657		Physiology	L81 >STOP - point mutation that introduces a premature stop codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, SNP N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002658	lectin-24A Q9VQU4	Physiology	Q254 >STOP - point mutation that introduces a premature stop codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, SNP N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002659	lectin-24A Q9VQU4	Physiology	F217 >STOP - point mutation that introduces a premature stop codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
LIN28B	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000548	LIN28B Q6ZN17	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		LIN28B	Homo sapiens human - (species)	Published - Accepted by Curator
Linamarase	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000549	LI P26205	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D		Linamarase	Trifolium repens white clover - (species)	Published - Accepted by Curator
lncRNA:Hsr omega	Temperature tolerance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	McKechnie SW; Halford MM; McColl G ; et al. (1998) Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closel[...] 1 Additional References McColl G; McKechnie SW (1999) The Drosophila heat shock hsr-omega gene: an allele frequency cline detected by quantitative PCR.	GP00001999		Physiology		Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		lncRNA:Hsr omega	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
LPAR1	Hematopoiesis (blood monocyte count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001612	LPAR1 Q92633	Physiology	A>G at the associated SNP. 2 variants located in an uncharacterized long noncoding RNA	Homo sapiens human - (species)	Homo sapiens human - (species)		LPAR1	Homo sapiens human - (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000553	P08659	Physiology	T739G and C740G in exon 4; leading to one amino acid change - colour difference between the yellow- and orange-emitting luciferases is due entirely to S247G	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	2 Mutations: Coding SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000554	P08659	Physiology	2 mutations	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00001758	P08659	Physiology	exact causing amino acid change(s) unknown	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
LY86	Body fat distribution (visceral/subcutaneous ratio)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001562	LY86 O95711	Physiology	A>T in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		LY86	Homo sapiens human - (species)	Published - Accepted by Curator
LYPLAL1	Body fat distribution (visceral/subcutaneous ratio)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001561	LYPLAL1 Q5VWZ2	Physiology	T>C in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		LYPLAL1	Homo sapiens human - (species)	Published - Accepted by Curator
M	Pathogen resistance	Coding, Deletion	Linum usitatissimum flax - (species) D	Intraspecific	Linkage Mapping	Anderson PA; Lawrence GJ; Morrish BC ; et al. (1997) Inactivation of the flax rust resistance gene M associated with loss of a repeated unit within the l[...]	GP00000559	P93244	Physiology	426bp deletion, probably by unequal recombination	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species) D		M	Linum usitatissimum flax - (species)	Published - Accepted by Curator
mab-23	Male genitalia	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Lints R; Emmons SW (2002) Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the [...] 1 Additional References Hodgkin J; Doniach T (1997) Natural variation and copulatory plug formation in Caenorhabditis elegans.	GP00001323	mab-23 G5ECK3	Morphology	TGC>TTC - cysteine of the DM motif transformed into phenylalanine; so is likely to disrupt DNA-binding function N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		mab-23	Caenorhabditis elegans (species)	Published - Accepted by Curator
Mac1	Virulence	Unknown, Unknown	Cryptococcus neoformans (species)	Intraspecific	Linkage Mapping	Lin X; Huang JC; Mitchell TG ; et al. (2006) Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha all[...]	GP00000560	CGB_D8050W E6R4R6	Physiology	unknown	Cryptococcus neoformans (species)	Cryptococcus neoformans (species)		Mac1	Cryptococcus neoformans (species)	Published - Accepted by Curator
MADS AFFECTING FLOWERING 2 (MAF2)	Flowering time	Cis-regulatory, Insertion	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Rosloski SM; Jali SS; Balasubramanian S ; et al. (2010) Natural diversity in flowering responses of Arabidopsis thaliana caused by variation in a tandem gen[...]	GP00000561	MAF2 Q84J38	Physiology	Insertion alleles - several	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		MADS AFFECTING FLOWERING 2 (MAF2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MAM1	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kroymann J; Textor S; Tokuhisa JG ; et al. (2001) A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chai[...] 3 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...] Züst T; Heichinger C; Grossniklaus U (2012) Natural enemies drive geographic variation in plant defenses.	GP00000562	MAM1 Q9FG67	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		MAM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MaMyb2	Coloration (flowers)	Cis-regulatory, Unknown	Diplacus aurantiacus (species)	Intraspecific	Linkage Mapping	Streisfeld MA; Young WN; Sobel JM (2013) Divergent selection drives genetic differentiation in an R2R3-MYB transcription factor that contribu[...]	GP00000563	Myb2 M9QXG2	Morphology	unknown expression-phenotype co-vary	Diplacus aurantiacus (species)	Diplacus aurantiacus (species)		MaMyb2	Diplacus aurantiacus (species)	Published - Accepted by Curator
MAP4K4	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Unknown, Unknown	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Guo Z; Kang S; Chen D ; et al. (2015) MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacil[...]	GP00001673	MAP4K4 O95819	Physiology	MAP4K4 constitutively up-regulated leading to up-regulated PxABCC1 and down-regulated PxABCC2 and PxABCC3 and reduction of membrane-bound ALP (mALP) expression responsible for reduced Cry1Ac toxin binding to midgut proteins	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		MAP4K4	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
MARVELD3	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Timmann C; Thye T; Vens M ; et al. (2012) Genome-wide association study indicates two novel resistance loci for severe malaria.	GP00000564	MARVELD3 Q96A59	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		MARVELD3	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000567	MC1R Q01726	Morphology	2bp deletion resulting in frameshift N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, SNP	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000568	MC1R Q01726	Morphology	Arg164Cys (position 160 in human; so this mutation resembles the human R160W hypomorphic human mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000576	MC1R Q01726	Morphology	R18C	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000577	MC1R Q01726	Morphology	R109W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000578	MC1R Q01726	Morphology	R160W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000579	MC1R Q01726	Morphology	Q233H	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Candidate Gene	Marklund L; Moller MJ; Sandberg K ; et al. (1996) A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated wit[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000580	MC1R Q01726	Morphology	S83F	Equus caballus horse - (species)	Equus caballus horse - (species)		MC1R	Equus caballus horse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Puma yagouaroundi jaguarundi - (species) D	Intraspecific	Candidate Gene	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000581	MC1R Q01726	Morphology	Deletion of aa 95-102	Puma yagouaroundi jaguarundi - (species)	Puma yagouaroundi jaguarundi - (species) D		MC1R	Puma yagouaroundi jaguarundi - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Wada A; Kunieda T; Nishimura M ; et al. (2005 Mar-Apr) A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred s[...]	GP00000586	MC1R Q01726	Morphology	W252C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Panthera onca jaguar - (species) D	Intraspecific	Candidate Gene	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000593	MC1R Q01726	Morphology	Deletion of aa 101-105 and L106T	Panthera onca jaguar - (species)	Panthera onca jaguar - (species) D		MC1R	Panthera onca jaguar - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Linkage Mapping	Hoekstra HE; Hirschmann RJ; Bundey RA ; et al. (2006) A single amino acid mutation contributes to adaptive beach mouse color pattern.	GP00000594	MC1R Q01726	Morphology	R65C	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		MC1R	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Sciurus carolinensis gray squirrel - (species) D Sciurus niger fox squirrel - (species) D	Intraspecific	Candidate Gene	McRobie H; Thomas A; Kelly J (2009 Nov-Dec) The genetic basis of melanism in the gray squirrel (Sciurus carolinensis). 1 Additional References McRobie HR; Moncrief ND; Mundy NI (2019) Multiple origins of melanism in two species of North American tree squirrel (Sciurus).	GP00000596	MC1R Q01726	Morphology	Deletion of 8 a.a.	Sciurus carolinensis gray squirrel - (species) Sciurus niger fox squirrel - (species)	Sciurus carolinensis gray squirrel - (species) D Sciurus niger fox squirrel - (species) D		MC1R	Sciurus carolinensis gray squirrel - (species) Sciurus niger fox squirrel - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ursus americanus American black bear - (species)	Intraspecific	Candidate Gene	Ritland K; Newton C; Marshall HD (2001) Inheritance and population structure of the white-phased "Kermode" black bear.	GP00000597	MC1R Q01726	Morphology	Y298C	Ursus americanus American black bear - (species)	Ursus americanus American black bear - (species)		MC1R	Ursus americanus American black bear - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Anser caerulescens snow goose - (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000599	MC1R Q01726	Morphology	V85M	Anser caerulescens snow goose - (species)	Anser caerulescens snow goose - (species)		MC1R	Anser caerulescens snow goose - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Coereba flaveola Bananaquit - (species) D	Intraspecific	Candidate Gene	Theron E; Hawkins K; Bermingham E ; et al. (2001) The molecular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor point mu[...]	GP00000600	MC1R Q01726	Morphology	E92K	Coereba flaveola Bananaquit - (species)	Coereba flaveola Bananaquit - (species) D		MC1R	Coereba flaveola Bananaquit - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, Deletion	Falco eleonorae (species) D	Intraspecific	Candidate Gene	Gangoso L; Grande JM; Ducrest AL ; et al. (2011) MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the E[...]	GP00000603	MC1R Q01726	Morphology	Deletion of 3 a.a.	Falco eleonorae (species)	Falco eleonorae (species) D		MC1R	Falco eleonorae (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Falco rusticolus gyrfalcon - (species)	Intraspecific	Candidate Gene	Johnson JA; Ambers AD; Burnham KK (2012 May-Jun) Genetics of plumage color in the Gyrfalcon (Falco rusticolus): analysis of the melanocortin-1 recept[...]	GP00000604	MC1R Q01726	Morphology	Val128Ile	Falco rusticolus gyrfalcon - (species)	Falco rusticolus gyrfalcon - (species)		MC1R	Falco rusticolus gyrfalcon - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Malurus leucopterus white-winged fairy-wren - (species)	Intraspecific	Candidate Gene	Doucet SM; Shawkey MD; Rathburn MK ; et al. (2004) Concordant evolution of plumage colour, feather microstructure and a melanocortin receptor gene betw[...]	GP00000610	MC1R Q01726	Morphology	A16T caused by guanine-to-adenine (G_A) transition at site 46; and/or I38N cause by a tyrosine-to-adenine (T_A) transition at site 113; and/or V11N caused by a G_A transition at site 331; and/or Q157R caused by an A_G substitution at site 470; Val166Ileu - exact causing amino acid change(s) unknown	Malurus leucopterus white-winged fairy-wren - (species)	Malurus leucopterus white-winged fairy-wren - (species)		MC1R	Malurus leucopterus white-winged fairy-wren - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Stercorarius parasiticus (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000611	MC1R Q01726	Morphology	R230H	Stercorarius parasiticus (species)	Stercorarius parasiticus (species)		MC1R	Stercorarius parasiticus (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula leucogaster (species)	Intraspecific	Candidate Gene	Baião PC; Parker PG (2012 May-Jun) Evolution of the melanocortin-1 receptor (MC1R) in Boobies and Gannets (Aves, Suliformes).	GP00000612	MC1R Q01726	Morphology	R112H	Sula leucogaster (species)	Sula leucogaster (species)		MC1R	Sula leucogaster (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula sula red-footed booby - (species)	Intraspecific	Candidate Gene	Baião PC; Schreiber E; Parker PG (2007 Jul-Aug) The genetic basis of the plumage polymorphism in red-footed boobies (Sula sula): a melanocortin-1 re[...]	GP00000613	MC1R Q01726	Morphology	V85M and/or H207R; current data cannot determine which one or if both these substitutions are underlying the phenotypic variation	Sula sula red-footed booby - (species)	Sula sula red-footed booby - (species)		MC1R	Sula sula red-footed booby - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Smith R; Healy E; Siddiqui S (1998) Melanocortin 1 receptor variants in an Irish population.	GP00000615	MC1R Q01726	Morphology	R151C	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000616	MC1R Q01726	Morphology	D294H	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000617	MC1R Q01726	Morphology	R160W	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Box NF; Wyeth JR; O'Gorman LE ; et al. (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. 3 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. Harding RM; Healy E; Ray AJ (2000) Evidence for variable selective pressures at MC1R. Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000618	MC1R Q01726	Morphology	Val60Leu	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000619	MC1R Q01726	Morphology	Asp84Glu	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000620	MC1R Q01726	Morphology	Val92Met	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000621	MC1R Q01726	Morphology	Arg142His	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000622	MC1R Q01726	Morphology	Arg151Cys	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000623	MC1R Q01726	Morphology	Ile155Thr	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000624	MC1R Q01726	Morphology	Arg160Trp	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000625	MC1R Q01726	Morphology	Arg163Gln	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000626	MC1R Q01726	Morphology	Asp294His	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Aspidoscelis inornatus Little striped whiptail - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000627	MC1R Q01726	Morphology	I170T	Aspidoscelis inornatus Little striped whiptail - (species)	Aspidoscelis inornatus Little striped whiptail - (species)		MC1R	Aspidoscelis inornatus Little striped whiptail - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Holbrookia maculata lesser earless lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000628	MC1R Q01726	Morphology	V168I; but failed functional validation in Rosenblum et al. 2010	Holbrookia maculata lesser earless lizard - (species)	Holbrookia maculata lesser earless lizard - (species)		MC1R	Holbrookia maculata lesser earless lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Sceloporus undulatus fence lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Römpler H; Schöneberg T ; et al. (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000629	MC1R Q01726	Morphology	H208Y	Sceloporus undulatus fence lizard - (species)	Sceloporus undulatus fence lizard - (species)		MC1R	Sceloporus undulatus fence lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Lalueza-Fox C; Römpler H; Caramelli D ; et al. (2007) A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals.	GP00000630	MC1R Q01726	Morphology	Arg307Gly	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Monarcha castaneiventris Makira monarch - (species) D	Intraspecific	Association Mapping	Uy JA; Cooper EA; Cutie S ; et al. (2016) Mutations in different pigmentation genes are associated with parallel melanism in island flycatcher[...]	GP00001333	MC1R Q01726	Morphology	Asp119Asn	Monarcha castaneiventris Makira monarch - (species)	Monarcha castaneiventris Makira monarch - (species) D		MC1R	Monarcha castaneiventris Makira monarch - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Arctocephalus gazella antarctic fur seal - (species) D	Intraspecific	Candidate Gene	Norris BJ; Whan VA (2008) A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sh[...]	GP00001338	MC1R Q01726	Morphology	c.C>T p.Ser291Phe	Arctocephalus gazella antarctic fur seal - (species)	Arctocephalus gazella antarctic fur seal - (species) D		MC1R	Arctocephalus gazella antarctic fur seal - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Tyto alba Barn owl - (species) D	Intraspecific	Candidate Gene	San-Jose LM; Ducrest AL; Ducret V ; et al. (2015) Effect of the MC1R gene on sexual dimorphism in melanin-based colorations. 3 Additional References San-Jose LM; Ducret V; Ducrest AL (2017) Beyond mean allelic effects: A locus at the major color gene MC1R associates also with differing lev[...] Burri R; Antoniazza S; Gaigher A (2016) The genetic basis of color-related local adaptation in a ring-like colonization around the Mediterra[...] San-Jose LM; Ducrest AL; Ducret V (2017) MC1R variants affect the expression of melanocortin and melanogenic genes and the association betwee[...]	GP00001339	MC1R Q01726	Morphology	p.Val126Ile	Tyto alba Barn owl - (species)	Tyto alba Barn owl - (species) D	R	MC1R	Tyto alba Barn owl - (species)	Reviewed	September 26, 2019 17:00
MC1R	Coloration (feathers)	Coding, SNP	Stercorarius parasiticus (species)	Intraspecific	Candidate Gene	Janssen K; Mundy NI (2013) Molecular population genetics of the melanic plumage polymorphism in Arctic skuas (Stercorarius para[...]	GP00001355	Mc1r Q01727	Morphology	Melanic and nonmelanic haplotypes in the Arctic skua are defined by three amino acid changes: nonmelanic: His8-Glu12-Arg230; melanic: Arg8-Lys12-His230. The effect of each single amino acid change has not been tested	Stercorarius parasiticus (species)	Stercorarius parasiticus (species)		MC1R	Stercorarius parasiticus (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Calidris pugnax ruff - (species) D	Intraspecific	Association Mapping	Lamichhaney S; Fan G; Widemo F ; et al. (2016) Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pug[...] 1 Additional References Küpper C; Stocks M; Risse JE (2016) A supergene determines highly divergent male reproductive morphs in the ruff.	GP00001466	MC1R Q01726	Morphology	Several amino acid changes. The His207Arg substitution most likely has functional consequences because the same variant is associated with light color in the red-footed booby.	Calidris pugnax ruff - (species)	Calidris pugnax ruff - (species) D		MC1R	Calidris pugnax ruff - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Leopardus geoffroyi Geoffroy's cat - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001733	MC1R Q01726	Morphology	All melanistic individuals were heterozygous for four variants that predicted three nonsynonymous substitutions, p.C125R, p.T177I, and p.G194S - In the laboratory mouse a Cys to Arg substitution at the site homologous to felid residue 125 causes constitutive activation of the receptor and the exact same change is thought to be responsible for melanism in the Alaska silver fox - therefore C125R is considered to be the likely causative alteration in the Geoffroy’s cat.	Leopardus geoffroyi Geoffroy's cat - (species)	Leopardus geoffroyi Geoffroy's cat - (species) D		MC1R	Leopardus geoffroyi Geoffroy's cat - (species)	Published - Accepted by Curator
MC4R	Feeding behavior	Coding, SNP	Astyanax mexicanus Mexican tetra - (species)	Intraspecific	Linkage Mapping	Aspiras AC; Rohner N; Martineau B ; et al. (2015) Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditio[...]	GP00000637	mc4r B0V1P1	Behavior	Gly145Ser (candidate mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species)		MC4R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC4R	Sexual maturation (onset)	Gene Amplification, Complex Change	Xiphophorus maculatus southern platyfish - (species)	Intraspecific	Linkage Mapping	Lampert KP; Schmidt C; Fischer P ; et al. (2010) Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorph[...]	GP00000638	mc4r B0V1P1	Physiology	unknown in the species used in crosses but a strong coreelation of gene copy number is found with the phenotype in two closely related species	Xiphophorus maculatus southern platyfish - (species)	Xiphophorus maculatus southern platyfish - (species)		MC4R	Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
MCO	Metal tolerance (copper)	Gene Amplification, Insertion	Erythranthe guttata spotted monkey flower - (species) D	Intraspecific	Linkage Mapping	Wright KM; Lloyd D; Lowry DB ; et al. (2013) Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus. 1 Additional References Wright Kevin M; Hellsten Uffe; Xu Chenling (2015 ) Adaptation to heavy-metal contaminated environments proceeds via selection on pre-existing genetic v[...]	GP00001814	LPR2 Q949X9	Physiology	several recent tandem duplications of this gene are responsible for the 12x increase in expression observed in copper tolerant lines - 6X fold enrichment of aligned reads at MCO	Erythranthe guttata spotted monkey flower - (species)	Erythranthe guttata spotted monkey flower - (species) D		MCO	Erythranthe guttata spotted monkey flower - (species)	Published - Accepted by Curator
MDR1	Xenobiotic resistance	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Kimchi-Sarfaty C; Oh JM; Kim IW ; et al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity.	GP00001858	ABCB1 P08183	Physiology	C3435T - synonymous mutation Ile - The SNP at position 26/3435 that changes the codon from ATC to ATT (Ile) reduces the codon usage from 47% to 35% (RSCU values change from 20.9 to 15.8). Leads to similar mRNA and protein levels but altered conformation of the protein.	Homo sapiens human - (species)	Homo sapiens human - (species) D		MDR1	Homo sapiens human - (species)	Published - Accepted by Curator
metallothionein (Mtn)	Metal tolerance	Gene Amplification, Complex Change	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Otto E; Young JE; Maroni G (1986) Structure and expression of a tandem duplication of the Drosophila metallothionein gene. 1 Additional References Maroni G; Wise J; Young JE (1987) Metallothionein gene duplications and metal tolerance in natural populations of Drosophila melanogas[...]	GP00000653	MtnA P04357	Physiology	Gene duplication	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		metallothionein (Mtn)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
metallothionein (MtnA)	Oxidative stress resistance	Cis-regulatory, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	Catalán A; Glaser-Schmitt A; Argyridou E ; et al. (2016) An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variatio[...]	GP00002018	MtnA P04357	Physiology	49bp deletion in the MtnA 3'UTR	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		metallothionein (MtnA)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
MFSD12	Coloration (skin)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Adhikari K; Mendoza-Revilla J; Sohail A ; et al. (2019) A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasi[...] 1 Additional References Crawford NG; Kelly DE; Hansen MEB (2017) Loci associated with skin pigmentation identified in African populations.	GP00002245	MFSD12 Q6NUT3	Morphology	Y182H N	Homo sapiens human - (species)	Homo sapiens human - (species) D		MFSD12	Homo sapiens human - (species)	Published - Accepted by Curator
MFSD12	Coloration (skin)	Cis-regulatory, Complex Change N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Crawford NG; Kelly DE; Hansen MEB ; et al. (2017) Loci associated with skin pigmentation identified in African populations.	GP00002246	MFSD12 Q6NUT3	Morphology	eight potentially causal SNPs cluster in two regions: one within MFSD12 (intronic SNP and synonymous SNP in exon 9) and the other ~7600 to 9000 base pairs (bp) upstream of MFSD12 ; many SNPs are in predicted regulatory regions active in melanocytes and/or keratinocytes show enhancer activity in luciferase expression assays N	Homo sapiens human - (species)	Homo sapiens human - (species) D		MFSD12	Homo sapiens human - (species)	Published - Accepted by Curator
Mi1.2	Pathogen resistance (parasite)	Unknown, Unknown	Solanum lycopersicum tomato - (species)	Intraspecific	Linkage Mapping	Rossi M; Goggin FL; Milligan SB ; et al. (1998) The nematode resistance gene Mi of tomato confers resistance against the potato aphid. 2 Additional References Seah S; Yaghoobi J; Rossi M (2004) The nematode-resistance gene, Mi-1, is associated with an inverted chromosomal segment in susceptibl[...] Vos P; Simons G; Jesse T (1998) The tomato Mi-1 gene confers resistance to both root-knot nematodes and potato aphids.	GP00000655	Mi-1.2 O81137	Physiology	Not identified	Solanum peruvianum (species)	Solanum lycopersicum tomato - (species)		Mi1.2	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
mir-92a	Trichome pattern (leg)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Arif S; Murat S; Almudi I ; et al. (2013) Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster.	GP00000661		Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		mir-92a	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
mitochondrial tyrosine tRNA	Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013) An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...] 1 Additional References Hoekstra LA; Siddiq MA; Montooth KL (2013) Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect o[...]	GP00001971		Physiology	C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)	Drosophila simulans (species)	Drosophila simulans (species) D		mitochondrial tyrosine tRNA	Drosophila simulans (species)	Published - Accepted by Curator
MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)	Ozone sensitivity (stomata opening and stomatal CO2-sensitivity)	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Jakobson L; Vaahtera L; Tõldsepp K ; et al. (2016) Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO[...]	GP00001383	MPK12 Q8GYQ5	Physiology	G53R	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Molybdenum transporter1 (MOT1)	Metal tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Baxter I; Muthukumar B; Park HC ; et al. (2008) Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is co[...] 1 Additional References Forsberg SK; Andreatta ME; Huang XY (2015) The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentratio[...]	GP00000676	MOT1 Q9SL95	Physiology	53bp deletion in promoter	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Molybdenum transporter1 (MOT1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Molybdenum transporter1 (MOT1)	Metal tolerance	Gene Amplification, Insertion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Association Mapping	Forsberg SK; Andreatta ME; Huang XY ; et al. (2015) The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentratio[...]	GP00000677	MOT1 Q9SL95	Physiology	330bp duplication followed by minor indels	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Molybdenum transporter1 (MOT1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Molybdenum transporter1 (MOT1)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Poormohammad Kiani S; Trontin C; Andreatta M ; et al. (2012) Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.	GP00001270	MOT1 Q9SL95	Physiology	D104Y	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Molybdenum transporter1 (MOT1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MPK12	Water absorption (water use efficiency)	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Des Marais DL; Auchincloss LC; Sukamtoh E ; et al. (2014) Variation in MPK12 affects water use efficiency in Arabidopsis and reveals a pleiotropic link betwee[...]	GP00001283	MPK12 Q8GYQ5	Physiology	GGT to CGT @position 53	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		MPK12	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001274	BGAL6 Q9FFN4	Physiology	C->T @position 2223 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001275	BGAL6 Q9FFN4	Physiology	G->C @position 2240 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001276	BGAL6 Q9FFN4	Physiology	G->T @position 3425 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001277	BGAL6 Q9FFN4	Physiology	TACA insertion @position 4906 causing frame shift + Stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Mucin gene family	Salt tolerance	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001378	MUC1 P15941	Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		Mucin gene family	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Multidrug resistance protein 1 (pvmdr1)	Xenobiotic resistance (mefloquine)	Gene Amplification, Insertion	Plasmodium vivax malaria parasite P. vivax - (species) D	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001482	B7STB0	Physiology	37 kb duplication on chromosome 10 that includes pvmdr1	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species) D		Multidrug resistance protein 1 (pvmdr1)	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
multidrug resistance protein 2	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001532	PF3D7_1447900 Q8IKZ6	Physiology	p.Thr484Ile	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		multidrug resistance protein 2	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
MX1	Pathogen resistance (myxovirus)	Coding, SNP	Gallus gallus chicken - (species) D	Intraspecific		Ko JH; Jin HK; Asano A ; et al. (2002) Polymorphisms and the differential antiviral activity of the chicken Mx gene.	GP00002249	MX1 P20591	Physiology	c.1892G>A p.S631N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		MX1	Gallus gallus chicken - (species)	Published - Accepted by Curator
MYB1	Coloration (flower)	Coding, Deletion N	Ipomoea purpurea common morning-glory - (species) D	Intraspecific	Candidate Gene	Chang SM; Lu Y; Rausher MD (2005) Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea.	GP00001458	myb1 Q4QS21	Morphology	2 deletions; 6-bp and 19-bp long; the larger produces a frameshift and a premature stop N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		MYB1	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
Na/K ATPase	Salt tolerance	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001377	ATP1A1 P05023	Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		Na/K ATPase	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Leptodactylus ocellatus argus frog - (species) D	Intraspecific	Candidate Gene	Moore DJ; Halliday DC; Rowell DM ; et al. (2009) Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000701	Atp1a1 Q8VDN2	Physiology	2 mutations	Leptodactylus ocellatus argus frog - (species)	Leptodactylus ocellatus argus frog - (species) D		Na/K-ATPase alpha-subunit	Leptodactylus ocellatus argus frog - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Wang ZJ; Liang CR; Shang ZY ; et al. (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]	GP00002491	nAChRbeta1 P04755	Physiology	R81T	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		nAChR	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Wang ZJ; Liang CR; Shang ZY ; et al. (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]	GP00002492	nAChRbeta1 P04755	Physiology	K264E	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		nAChR	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Puinean AM; Andrews M ; et al. (2011) Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotin[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]	GP00002553	nAChRbeta1 P04755	Physiology	R81T in the loop D region of the nAChR β1 subunit of the resistant clone	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		nAChR	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad; spirotetramat)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Puinean AM; Lansdell SJ; Collins T ; et al. (2013) A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance t[...] 3 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Sun LN; Shen XJ; Cao LJ (2022) Increasing Frequency of G275E Mutation in the Nicotinic Acetylcholine Receptor α6 Subunit Conferring[...] Zimmer CT; Garrood WT; Puinean AM (2016) A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor[...]	GP00002554	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		nAChR	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao WX; Narai Y; Nakano A ; et al. (2014) Spinosad resistance of melon thrips, Thrips palmi, is conferred by G275E mutation in α6 subunit of n[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002555	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Thrips palmi (species)	Thrips palmi (species) D		nAChR	Thrips palmi (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Xu X; Ding Q; Wang X ; et al. (2022) V101I and R81T mutations in the nicotinic acetylcholine receptor β1 subunit are associated with neon[...]	GP00002612	nAChRbeta1 P04755	Physiology	V101I	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		nAChR	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Silva WM; Berger M; Bass C ; et al. (2016) Mutation (G275E) of the nicotinic acetylcholine receptor α6 subunit is associated with high levels o[...] 1 Additional References Zimmer CT; Garrood WT; Puinean AM (2016) A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor[...]	GP00002621	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Tuta absoluta (species)	Tuta absoluta (species) D		nAChR	Tuta absoluta (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Unknown N	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Feng HT; Wu WJ ; et al. (2012) Truncated transcripts of nicotinic acetylcholine subunit gene Bdα6 are associated with spinosad resi[...]	GP00002650	CHRNA6 Q15825	Physiology	Mutation in Bdα6 intron 2 (A change to T) just before the truncated/mis-splicing region and in same location with a mutation previously reported in the Pxylα6 gene. Small deletions and insertions leading to premature stop codons in exon 7. N	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D		nAChR	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, SNP N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Chen M; Dawson A ; et al. (2010) Mis-spliced transcripts of nicotinic acetylcholine receptor alpha6 are associated with field evolved[...]	GP00002651	CHRNA6 Q15825	Physiology	A mutation within the ninth intron splice junction of Pxalpha6 results in mis-splicing of transcripts and produce a predicted protein truncated between the third and fourth transmembrane domains. N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		nAChR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Chen M; Shelton AM ; et al. (2010) Transcripts of the nicotinic acetylcholine receptor subunit gene Pxylα6 with premature stop codons a[...]	GP00002652	CHRNA6 Q15825	Physiology	transcripts with premature stop codons N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		nAChR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Deletion N	Rhyzopertha dominica lesser grain borer - (species) D	Intraspecific	Candidate Gene	Wang HT; Tsai CL; Chen ME (2018) Nicotinic acetylcholine receptor subunit α6 associated with spinosad resistance in Rhyzopertha domin[...]	GP00002654	CHRNA6 Q15825	Physiology	Three mutations were found in the resistant strain compared with the susceptible one: (1) a 181-bp fragment truncated at the N-terminus resulting in the appearance of a premature stop codon - (2) one missing bp at the position 997 causing a frame-shift mutation and (3) an 87-bp fragment truncated in the TM2 region. N	Rhyzopertha dominica lesser grain borer - (species)	Rhyzopertha dominica lesser grain borer - (species) D		nAChR	Rhyzopertha dominica lesser grain borer - (species)	Published - Accepted by Curator
nath-10	Fertility (sperm number; egg laying rate)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Duveau F; Félix MA (2012) Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.	GP00000718	nath-10 O01757	Morphology	Met746Ile (according to Table S2 C>T but it should be G>A - Needs curation)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		nath-10	Caenorhabditis elegans (species)	Published - Accepted by Curator
natriuretic peptide precursor type C (NPPC)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Estrada K; Krawczak M; Schreiber S ; et al. (2009) A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide si[...]	GP00000719	Nppc Q61839	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		natriuretic peptide precursor type C (NPPC)	Homo sapiens human - (species)	Published - Accepted by Curator
natriuretic peptide receptor 3 (NPR3)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Estrada K; Krawczak M; Schreiber S ; et al. (2009) A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide si[...] 1 Additional References Soranzo N; Rivadeneira F; Chinappen-Horsley U (2009) Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations wi[...]	GP00000720	NPR3 Q8L746	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		natriuretic peptide receptor 3 (NPR3)	Homo sapiens human - (species)	Published - Accepted by Curator
Nav1.6 sodium channel	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000735	SCN8A Q9UQD0	Physiology	Ile1709Val	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D		Nav1.6 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
Nav1.7 sodium channel	Xenobiotic resistance (TTX)	4 Mutations: Coding SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000736	SCN9A Q15858	Physiology	4 mutations	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D		Nav1.7 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
ndp (norrin)	Coloration (plumage)	Cis-regulatory, Insertion	Corvus cornix hooded crow - (species) D	Intraspecific	Association Mapping	Knief U; Bossu CM; Saino N ; et al. (2019) Epistatic mutations under divergent selection govern phenotypic variation in the crow hybrid zone. 2 Additional References Poelstra JW; Vijay N; Hoeppner MP (2015) Transcriptomics of colour patterning and coloration shifts in crows. Weissensteiner MH; Bunikis I; Catalán A (2020) Discovery and population genomics of structural variation in a songbird genus.	GP00002148	Ndp P48744	Morphology	2.25-kb LTR retrotransposon insertion reducing expression of the NDP gene and candidate gene LRP6 and a large LD haplotype in chr.18 also show a signal	Corvus corone corone (subspecies)	Corvus cornix hooded crow - (species) D		ndp (norrin)	Corvus cornix hooded crow - (species)	Published - Accepted by Curator
ndp (norrin)	Coloration (plumage)	Cis-regulatory, Insertion N	Columba livia rock pigeon - (species) D Columba guinea speckled pigeon - (species) D	Intraspecific	Association Mapping	Vickrey AI; Bruders R; Kronenberg Z ; et al. (2018) Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity i[...]	GP00002251	Ndp P48744	Morphology	CNV driven by tandem repeats with one (bar) two (checker) or four (T-checker) copies per chromosome between approximative positions 1790000 and 1805600 N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D Columba guinea speckled pigeon - (species) D		ndp (norrin)	Columba livia rock pigeon - (species) Columba guinea speckled pigeon - (species)	Published - Accepted by Curator
Not much yang (Nmy)	Sex determination (sex ratio distortion)	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Tao Y; Masly JP; Araripe L ; et al. (2007) A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor. 1 Additional References Tao Y; Araripe L; Kingan SB (2007) A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.	GP00001970		Physiology	Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus and loss of most of the sequence located between the inverted repeats (except for a 93bp element in reverse orientation).	Drosophila simulans (species)	Drosophila simulans (species) D		Not much yang (Nmy)	Drosophila simulans (species)	Published - Accepted by Curator
npr-1	Aggregation behavior Foraging behavior CO2 avoidance Pathogen avoidance Fertility (competitive fitness)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	de Bono M; Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in[...] 5 Additional References Gloria-Soria A; Azevedo RB (2008) npr-1 Regulates foraging and dispersal strategies in Caenorhabditis elegans. Andersen EC; Bloom JS; Gerke JP (2014) A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth[...] McGrath PT; Rockman MV; Zimmer M (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] Reddy KC; Andersen EC; Kruglyak L (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Burga A; Ben-David E; Lemus Vergara T (2019) Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk.	GP00000739	npr-1 Q18534	Behavior Behavior Behavior Behavior Behavior; Physiology	Val215Phe (pleiotropic; see other entries)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		npr-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000745	Oca2 Q62052	Morphology Physiology	Deletion of exon 21 N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000746	Oca2 Q62052	Morphology Physiology	Almost complete deletion of exon 24; + 2 a.a subsitutions at conserved positions - the two point mutations do not drastically affect the function of OCA2 in cell lines suggesting that the exon 24 deletion is the mutation that causes albinism in the Pachón population N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (eyes; skin, hair)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Eiberg H; Troelsen J; Nielsen M ; et al. (2008) Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory el[...] 5 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...] Visser M; Kayser M; Palstra RJ (2012) HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long[...] Beleza S; Johnson NA; Candille SI (2013) Genetic architecture of skin and eye color in an African-European admixed population. Crawford NG; Kelly DE; Hansen MEB (2017) Loci associated with skin pigmentation identified in African populations. Lona-Durazo F; Hernandez-Pacheco N; Fan S (2019) Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation [...]	GP00000747	Oca2 Q62052	Morphology	Causative SNP in enhancer localized in intron of neighbor gene HERC2 : likely rs12913832 within HERC2 which influences on OCA2 expression in eye hair and skin pigmentation	Homo sapiens human - (species)	Homo sapiens human - (species)		Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
Oca2	Coloration (skin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Edwards M; Bigham A; Tan J ; et al. (2010) Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: furth[...] 1 Additional References Yang Z; Zhong H; Chen J (2016) A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution.	GP00000748	Oca2 Q62052	Morphology	His615Arg	Homo sapiens human - (species)	Homo sapiens human - (species) D		Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Insertion N	Pantherophis guttatus (species) D	Intraspecific	Linkage Mapping	Saenko SV; Lamichhaney S; Martinez Barrio A ; et al. (2015) Amelanism in the corn snake is associated with the insertion of an LTR-retrotransposon in the OCA2 g[...]	GP00001619	OCA2 Q04671	Morphology	insertion of an LTR-retrotransposon (5832-bp) in the 11th intron resulting after splicing in an additional 397-bp fragment constituted of 3 new exons inserted between exons 11 and 12. Generates truncated protein with two stop codons N	Pantherophis guttatus (species)	Pantherophis guttatus (species) D		Oca2	Pantherophis guttatus (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Deletion N	Melanochromis auratus (species) D	Intraspecific	Candidate Gene	Kratochwil CF; Urban S; Meyer A (2019) Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an ame[...]	GP00001955	Oca2 Q62052	Morphology	deletion covering a total of 5.4kb including exon 2 and parts of the flanking introns 1 and 2 N	Melanochromis auratus (species)	Melanochromis auratus (species) D		Oca2	Melanochromis auratus (species)	Published - Accepted by Curator
OPRM1	Coloration (skin)	Unknown, Unknown	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Quillen EE; Bauchet M; Bigham AW ; et al. (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...]	GP00001536	OPRM1 P35372	Morphology	C>T associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species) D		OPRM1	Homo sapiens human - (species)	Published - Accepted by Curator
opsin - (SWS2)	Color vision (blue- and red-shifts)	2 Mutations: Coding SNP	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Candidate Gene	Marques DA; Taylor JS; Jones FC ; et al. (2017) Convergent evolution of SWS2 opsin facilitates adaptive radiation of threespine stickleback into dif[...]	GP00001679	opn1sw2 Q9W6A8	Physiology	2 mutations	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		opsin - (SWS2)	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	3 Mutations: Coding SNP	Pundamilia pundamilia (species)	Intraspecific	Candidate Gene	Seehausen O; Terai Y; Magalhaes IS ; et al. (2008) Speciation through sensory drive in cichlid fish.	GP00000777	OPN1LW P04000	Physiology	3 mutations	Pundamilia pundamilia (species)	Pundamilia pundamilia (species)		opsin - rhodopsin (LWS)	Pundamilia pundamilia (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (green-shift)	Coding, SNP	Stomoxys calcitrans stable fly - (species)	Intraspecific	Candidate Gene	Olafson PU; Aksoy S; Attardo GM ; et al. (2021) The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduct[...]	GP00002535	RHO P08100	Physiology	Met>Leucine residue present at tuning site 17 which is extremely rare across insect LW opsins. In a survey of over 100 insect LW opsins it was detected only in the two corresponding Rh1 orthologs from M. domestica in addition to one in the distantly related species of thrips (Thysanoptera). The site is residue 17 based on the numbering system developed for butterflies which corresponds to residue 57 in Drosophila Rh1.	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species)		opsin - rhodopsin1 (RH1)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius pachinus (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000795	Optix Q95RW8	Morphology	Not identified	Heliconius cydno (species)	Heliconius pachinus (species)		Optix	Heliconius pachinus (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius himera (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000796	Optix Q95RW8	Morphology	Not identified	Heliconius erato crimson-patched longwing - (species)	Heliconius himera (species)		Optix	Heliconius himera (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius erato crimson-patched longwing - (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000797	Optix Q95RW8	Morphology	Not identified	Heliconius erato crimson-patched longwing - (species)	Heliconius erato crimson-patched longwing - (species)		Optix	Heliconius erato crimson-patched longwing - (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius melpomene postman butterfly - (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000798	Optix Q95RW8	Morphology	Not identified	Heliconius melpomene postman butterfly - (species)	Heliconius melpomene postman butterfly - (species)		Optix	Heliconius melpomene postman butterfly - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000799	OR7D4 Q8NG98	Physiology	P79L	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000800	OR7D4 Q8NG98	Physiology	R227G	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000801	OR7D4 Q8NG98	Physiology	T133M	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000802	OR7D4 Q8NG98	Physiology	S84N	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
ore	Taste (fruit)	Coding, SNP	Cucumis sativus cucumber - (species) D	Intraspecific	Candidate Gene	Qi J; Liu X; Shen D ; et al. (2013) A genomic variation map provides insights into the genetic basis of cucumber domestication and diver[...]	GP00001390	BCH1 E9JE14	Morphology; Physiology	p.Ala257Asp	Cucumis sativus cucumber - (species)	Cucumis sativus cucumber - (species) D		ore	Cucumis sativus cucumber - (species)	Published - Accepted by Curator
ORGANIC CATION TRANSPORTER 1	Root growth (root length response to exogenous cadaverine)	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Strohm AK; Vaughn LM; Masson PH (2015) Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to[...]	GP00001279	OCT1 Q9CAT6	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ORGANIC CATION TRANSPORTER 1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Overdrive	Hybrid incompatibility (male F1 sterility)	Coding, SNP	Drosophila pseudoobscura (species)	Intraspecific	Linkage Mapping	Phadnis N; Orr HA (2009) A single gene causes both male sterility and segregation distortion in Drosophila hybrids.	GP00000816	Ovd Q2LZF7	Physiology	6 candidate non-synonymous changes - the effect of single amino acid changes has not been tested	Drosophila pseudoobscura (species)	Drosophila pseudoobscura (species)		Overdrive	Drosophila pseudoobscura (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00000817	LPAR6 P43657	Morphology	at position 69 insertion of 4bp CATG - causes frameshift at codon 24 (PTC +29) N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001734	LPAR6 P43657	Morphology	2 deletions - one at position 172-175 delAACT and one at position 177 delG - cause frameshift at codon 58 (PTC +31) N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001735	LPAR6 P43657	Morphology	188A>T which causes D63V N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001736	LPAR6 P43657	Morphology	562A>T which causes I188F N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001737	LPAR6 P43657	Morphology	565G>A which causes E189K N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
pannier	Coloration (elytra)	Cis-regulatory, Unknown	Harmonia axyridis (species)	Intraspecific	Association Mapping	Ando T; Niimi T (2019) Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis. 2 Additional References Gautier M; Yamaguchi J; Foucaud J (2018) The Genomic Basis of Color Pattern Polymorphism in the Harlequin Ladybird. Ando T; Niimi T (2019) Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis.	GP00001705	pnr P52168	Morphology	exact mutation(s) unknown	Harmonia axyridis (species)	Harmonia axyridis (species)		pannier	Harmonia axyridis (species)	Published - Accepted by Curator
pannier	Coloration (elytra)	Cis-regulatory, Unknown	Harmonia axyridis (species)	Intraspecific	Association Mapping	Ando T; Niimi T (2019) Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis. 2 Additional References Gautier M; Yamaguchi J; Foucaud J (2018) The Genomic Basis of Color Pattern Polymorphism in the Harlequin Ladybird. Ando T; Niimi T (2019) Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis.	GP00001706	pnr P52168	Morphology	exact mutation(s) unknown	Harmonia axyridis (species)	Harmonia axyridis (species)		pannier	Harmonia axyridis (species)	Published - Accepted by Curator
pannier	Coloration (elytra)	Cis-regulatory, Unknown	Harmonia axyridis (species)	Intraspecific	Association Mapping	Ando T; Niimi T (2019) Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis. 2 Additional References Gautier M; Yamaguchi J; Foucaud J (2018) The Genomic Basis of Color Pattern Polymorphism in the Harlequin Ladybird. Ando T; Niimi T (2019) Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis.	GP00001707	pnr P52168	Morphology	exact mutation(s) unknown	Harmonia axyridis (species)	Harmonia axyridis (species)		pannier	Harmonia axyridis (species)	Published - Accepted by Curator
PAP1	Coloration (anthocyanin accumulation under high-light and low-temperature stress)	Gene Loss, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ilk N; Ding J; Ihnatowicz A ; et al. (2015) Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...] 1 Additional References Teng S; Keurentjes J; Bentsink L (2005) Sucrose-specific induction of anthocyanin biosynthesis in Arabidopsis requires the MYB75/PAP1 gene.	GP00001232	MYB75 Q9FE25	Physiology	several deletions in the promoter; first intron; second exon and 3' UTR region (putative loss of function) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		PAP1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
PAP2	Coloration (anthocyanin accumulation under high-light and low-temperature stress)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ilk N; Ding J; Ihnatowicz A ; et al. (2015) Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]	GP00001231	MYB90 Q9ZTC3	Physiology	one SNP in the coding region and several in the putative promoter region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		PAP2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...] 1 Additional References Grigoraki L; Cowlishaw R; Nolan T (2021) CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	2 mutations	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005) Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...] 1 Additional References Franck P; Siegwart M; Olivares J (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D		para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000839	para P35500	Physiology	L925I in species D	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000840	para P35500	Physiology	M918L - ATG>CTG	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000841	para P35500	Physiology	2 mutations	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	3 Mutations: Coding SNP	Pediculus humanus human louse - (species) D	Intraspecific	Candidate Gene	Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010) Determination of knockdown resistance allele frequencies in global human head louse populations usin[...] 3 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Lee Si Hyeock; Gao Jian-Rong; Yoon Kyong Sup (2003 ) Sodium channel mutations associated with knockdown resistance in the human head louse, Pediculus cap[...]	GP00000846	para P35500	Physiology	3 mutations	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D		para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D		para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Sonoda S; Igaki C; Tsumuki H (2008) Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000848	para P35500	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)		para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001689	para P35500	Physiology	L1014F; Haplotype H02	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001691	para P35500	Physiology	L1014S; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species)		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles vagus (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001692	para P35500	Physiology	L1014S	Anopheles vagus (species)	Anopheles vagus (species) D		para (kdr)	Anopheles vagus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001695	para P35500	Physiology	L1014S	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles paraliae (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001696	para P35500	Physiology	L1014S	Anopheles paraliae (species)	Anopheles paraliae (species)		para (kdr)	Anopheles paraliae (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001699	para P35500	Physiology	L1014F; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Cimex lectularius bed bug - (species) D	Intraspecific	Candidate Gene	Yoon KS; Kwon DH; Strycharz JP ; et al. (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] 4 Additional References Yoon KS; Kwon DH; Strycharz JP (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] Seong KM; Lee DY; Yoon KS (2010) Establishment of quantitative sequencing and filter contact vial bioassay for monitoring pyrethroid [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Durand R; Cannet A; Berdjane Z (2012) Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France.	GP00001859	para P35500	Physiology	2 mutations	Cimex lectularius bed bug - (species)	Cimex lectularius bed bug - (species) D		para (kdr)	Cimex lectularius bed bug - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	González-Cabrera J; Davies TG; Field LM ; et al. (2013) An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor. 1 Additional References Hubert J; Nesvorna M; Kamler M (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00001860	para P35500	Physiology	L925V	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001861	para P35500	Physiology	M918L - found in samples from China and Europe	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)		para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001862	para P35500	Physiology	2 mutations	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)		para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species)	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001863	para P35500	Physiology	M918L - ATG>TTG - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).	Hyalella azteca (species)	Hyalella azteca (species)		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001864	para P35500	Physiology	L925V	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 3 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...] Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] Fontaine S; Caddoux L; Brazier C (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...]	GP00001865	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 1 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...]	GP00001866	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 2 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...] Brengues C; Hawkes NJ; Chandre F (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...]	GP00002444	para P35500	Physiology	V1016G	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002445	para P35500	Physiology	F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	3 Mutations: Coding SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Plernsub S; Saingamsook J; Yanola J ; et al. (2016) Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002446	para P35500	Physiology	3 mutations	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Kasai S; Ng LC; Lam-Phua SG ; et al. (2011) First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus. 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002447	para P35500	Physiology	F1534C	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002469	para P35500	Physiology	L1014S	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D		para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002470	para P35500	Physiology	L1014F	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D		para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002486	para P35500	Physiology	2 mutations	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002487	para P35500	Physiology	2 mutations	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		para (kdr)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Haddi K; Tomé HVV; Du Y ; et al. (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...] 1 Additional References Fan Y; O'Grady P; Yoshimizu M (2020) Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes ae[...]	GP00002488	para P35500	Physiology	2 mutations	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Zhang L; Li T ; et al. (2012) Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following i[...]	GP00002489	para P35500	Physiology	3 nonsynonymous A(109)S L(982)F and W(1573)R) and 6 synonymous L(852) G(891) A(1241) D(1245) P(1249) and G(1733)) mutations were identified. The co-existence of all 9 mutations and their homozygousity were found to be important factors for high levels of resistance.	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Marshall Kate L; Moran Christopher; Chen Yizhou ; et al. (2012 ) Detection of kdr pyrethroid resistance in the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), u[...] 2 Additional References Wang ZJ; Liang CR; Shang ZY (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002490	para P35500	Physiology	L1014F	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Linkage Mapping	Nyoni BN; Gorman K; Mzilahowa T ; et al. (2011) Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation[...]	GP00002493	para P35500	Physiology	M918T - first report of the M918T mutation in the absence of L1014F in any arthropod species.	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D		para (kdr)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Liriomyza huidobrensis pea leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002494	para P35500	Physiology	2 mutations	Liriomyza huidobrensis pea leafminer - (species)	Liriomyza huidobrensis pea leafminer - (species) D		para (kdr)	Liriomyza huidobrensis pea leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Liriomyza sativae vegetable leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002495	para P35500	Physiology	L1014F	Liriomyza sativae vegetable leafminer - (species)	Liriomyza sativae vegetable leafminer - (species) D		para (kdr)	Liriomyza sativae vegetable leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002496	para P35500	Physiology	2 mutations	Thrips tabaci (species)	Thrips tabaci (species) D		para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002497	para P35500	Physiology	T929I	Thrips tabaci (species)	Thrips tabaci (species) D		para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Carletto J; Martin T; Vanlerberghe-Masutti F ; et al. (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii.	GP00002498	para P35500	Physiology	M918L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002499	para P35500	Physiology	M918L in species B	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002500	para P35500	Physiology	M918L in species C	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Wu M; Gotoh H; Waters T ; et al. (2014) Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002501	para P35500	Physiology	2 mutations	Thrips tabaci (species)	Thrips tabaci (species) D		para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Morgan JA; Corley SW; Jackson LA ; et al. (2009) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boop[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002502	para P35500	Physiology	L925I - Cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216 results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly Bemisia tabaci.	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao Wen Xue; Sonoda Shoji (2012 ) Resistance to cypermethrin in melon thrips, Thrips palmi (Thysanoptera: Thripidae), is conferred by [...]	GP00002503	para P35500	Physiology	T929I	Thrips palmi (species)	Thrips palmi (species) D		para (kdr)	Thrips palmi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002504	para P35500	Physiology	T929I	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitophilus zeamais maize weevil - (species) D	Intraspecific	Candidate Gene	Araújo RA; Williamson MS; Bass C ; et al. (2011) Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gat[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002505	para P35500	Physiology	T929I	Sitophilus zeamais maize weevil - (species)	Sitophilus zeamais maize weevil - (species) D		para (kdr)	Sitophilus zeamais maize weevil - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002506	para P35500	Physiology	T929V	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002507	para P35500	Physiology	T929C	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002508	para P35500	Physiology	T929I	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002509	para P35500	Physiology	L1014F	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Endersby NM; Viduka K; Baxter SW ; et al. (2011) Widespread pyrethroid resistance in Australian diamondback moth, Plutella xylostella (L.), is relate[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002510	para P35500	Physiology	F1020S	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002511	para P35500	Physiology	T929V	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002514	para P35500	Physiology	T929V	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002515	para P35500	Physiology	L1014F	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Jonsson NN; Cutullè C; Corley SW ; et al. (2010) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus microp[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00002516	para P35500	Physiology	G72V = G933V - G toT non-synonymous mutation at nucleotide position 214 that results in a glycine to valine substitution (G72V)	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002517	para P35500	Physiology	I951V = I936V	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Lepeophtheirus salmonis salmon louse - (species) D	Intraspecific	Candidate Gene	Fallang A; Denholm I; Horsberg TE ; et al. (2005) Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice Lepeophtheirus salm[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002518	para P35500	Physiology	Q945R in transmembrane segment IIS5	Lepeophtheirus salmonis salmon louse - (species)	Lepeophtheirus salmonis salmon louse - (species) D		para (kdr)	Lepeophtheirus salmonis salmon louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Brengues C; Hawkes NJ; Chandre F ; et al. (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002519	para P35500	Physiology	I104M = I1011M	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Saavedra-Rodriguez K; Urdaneta-Marquez L; Rajatileka S ; et al. (2007) A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin A[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002520	para P35500	Physiology	I1011V	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Enayati AA; Vatandoost H; Ladonni H ; et al. (2003) Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Ano[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Safi NHZ; Ahmadi AA; Nahzat S (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002521	para P35500	Physiology	L1014F - one point mutation difference involving a single A-T base change encoding a leucine to phenylalanine amino acid substitution in the pyrethroid-resistant strain.	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D		para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Safi NHZ; Ahmadi AA; Nahzat S ; et al. (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002522	para P35500	Physiology	L1014S	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D		para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles subpictus (species) D	Intraspecific	Candidate Gene	Karunaratne SHPP; Hawkes Nicola J; Perera MDB ; et al. (2007 ) Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populatio[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002523	para P35500	Physiology	L1014F - TTA>TTT	Anopheles subpictus (species)	Anopheles subpictus (species) D		para (kdr)	Anopheles subpictus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Liu H; Zhang L ; et al. (2005) Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002524	para P35500	Physiology	L1014F	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	D	Intraspecific	Candidate Gene	Rothwell JT; Morgan JA; James PJ ; et al. (2011) Mechanism of resistance to synthetic pyrethroids in buffalo flies in south-east Queensland. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002525	para P35500	Physiology	L1014F		D		para (kdr)		Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Brassicogethes aeneus (species)	Intraspecific	Candidate Gene	Nauen Ralf; Zimmer Christoph T; Andrews Melanie ; et al. (2012 ) Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F.[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002526	para P35500	Physiology	L1014F - found in individuals from Denmark and Sweden	Brassicogethes aeneus (species)	Brassicogethes aeneus (species)		para (kdr)	Brassicogethes aeneus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Foster SP; Paul VL; Slater R ; et al. (2014) A mutation (L1014F) in the voltage-gated sodium channel of the grain aphid, Sitobion avenae, is asso[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002527	para P35500	Physiology	L1014F	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D		para (kdr)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Cerchiari B; Giannini S ; et al. (2005) Use of the RFLP-PCR diagnostic test for characterizing MACE and kdr insecticide resistance in the pe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002528	para P35500	Physiology	F979S (housefly numbering) located inside the linker segment IIS5-6	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species)	Intraspecific	Candidate Gene	Stump AD; Atieli FK; Vulule JM ; et al. (2004) Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles ga[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002529	para P35500	Physiology	L1014S	Anopheles arabiensis (species)	Anopheles arabiensis (species)		para (kdr)	Anopheles arabiensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Dykes CL; Das MK ; et al. (2010) Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in [...]	GP00002530	para P35500	Physiology	L1014S	Anopheles culicifacies (species)	Anopheles culicifacies (species) D		para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Bali P; Hemingway J ; et al. (2009) PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato.	GP00002531	para P35500	Physiology	L1014F	Anopheles culicifacies (species)	Anopheles culicifacies (species) D		para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Lüleyap HU; Alptekin D; Kasap H ; et al. (2002) Detection of knockdown resistance mutations in Anopheles sacharovi (Diptera: Culicidae) and genetic [...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...]	GP00002532	para P35500	Physiology	L1014S	Anopheles sacharovi (species)	Anopheles sacharovi (species)		para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002533	para P35500	Physiology	L1014F	Anopheles sacharovi (species)	Anopheles sacharovi (species)		para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Pitzer JB; Kaufman PE (2011) Identification of a mutation associated with permethrin resistance in the para-type sodium channel o[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Olafson PU; Kaufman PE; Duvallet G (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002534	para P35500	Physiology	L1014H	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D		para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Kang S; Jung J; Lee S ; et al. (2012) The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles si[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002536	para P35500	Physiology	L1014C	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002537	para P35500	Physiology	L1014C in Nicaragua and Costa Rica individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D		para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002538	para P35500	Physiology	L1014F in Mexico individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D		para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Wang ZM; Li CX; Xing D ; et al. (2012) Detection and widespread distribution of sodium channel alleles characteristic of insecticide resist[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002539	para P35500	Physiology	L1014C	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Li CX; Wang ZM ; et al. (2012) First detection of multiple knockdown resistance (kdr)-like mutations in voltage-gated sodium channe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002540	para P35500	Physiology	L1014W	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Pridgeon Julia W; Appel Arthur G; Moar William J ; et al. (2002 ) Variability of resistance mechanisms in pyrethroid resistant German cockroaches (Dictyoptera: Blatte[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002541	para P35500	Physiology	F999S = F1020S - T to C at nt 2996 resulting in a phenylalanine999 to serine999 amino acid change	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Clark J Marshall; Lee Si Hyeock (2010 ) Cloning of a sodium channel gene and identification of mutations putatively associated with fenpropa[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002542	para P35500	Physiology	L1024V	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002543	para P35500	Physiology	A1549V = A1410V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002544	para P35500	Physiology	A1648V = A1494V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kawada H; Higa Y; Komagata O ; et al. (2009) Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroi[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002545	para P35500	Physiology	F1269C = F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus cinnabarinus carmine spider mite - (species) D	Intraspecific	Candidate Gene	Feng YN; Zhao S; Sun W ; et al. (2011) The sodium channel gene in Tetranychus cinnabarinus (Boisduval): identification and expression analy[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002546	para P35500	Physiology	F1538I	Tetranychus cinnabarinus carmine spider mite - (species)	Tetranychus cinnabarinus carmine spider mite - (species) D		para (kdr)	Tetranychus cinnabarinus carmine spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Tsagkarakou A; Van Leeuwen T; Khajehali J ; et al. (2009) Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-s[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002547	para P35500	Physiology	F1538I	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002548	para P35500	Physiology	M1524I	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Hubert J; Nesvorna M; Kamler M ; et al. (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00002549	para P35500	Physiology	F975L	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002550	para P35500	Physiology	F1528L+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]	GP00002551	para P35500	Physiology	F758L+L826P+I982V+M1055I = F1528L+L1596P+I1752V+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Kaufman PE; Duvallet G ; et al. (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002613	para P35500	Physiology	L1014F	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D		para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002614	para P35500	Physiology	M918I ATG>ATT	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002615	para P35500	Physiology	M918I ATG>ATA	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kushwah RBS; Kaur T; Dykes CL ; et al. (2020) A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegy[...]	GP00002625	para P35500	Physiology	F1534L - Phe (TTC) > Leu (CTC)	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002629	para P35500	Physiology	F1845Y	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002630	para P35500	Physiology	V1848I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002631	para P35500	Physiology	V1848I	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002632	para P35500	Physiology	F1845Y	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002644	para P35500	Physiology	super-kdr+D600N - super-kdr+D600N confers higher levels of resistance to seven pyrethroids relative to super-kdr.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002645	para P35500	Physiology	kdr+T929I - addition of T929I to the kdr mutation (L1014F) increased resistance to all pyrethroids (except etofenprox) and enhanced resistance by ~1000-fold to acrinathrin and flumethrin.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002646	para P35500	Physiology	F1534S	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002647	para P35500	Physiology	I1532T	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Fontaine S; Caddoux L; Brazier C ; et al. (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...] 1 Additional References Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00002649	para P35500	Physiology	L932F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
pastrel	Pathogen resistance (viruses)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Magwire MM; Fabian DK; Schweyen H ; et al. (2012) Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving [...]	GP00000854	pst Q8IQ82	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		pastrel	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Patched1 (Ptc1)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000855	ptch1 Q98864	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		Patched1 (Ptc1)	Homo sapiens human - (species)	Published - Accepted by Curator
pax7a	Coloration (scales)	Cis-regulatory, Unknown	Labeotropheus trewavasae (species)	Intraspecific	Candidate Gene	Roberts RB; Moore EC; Kocher TD (2017) An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid f[...]	GP00001422	Pax7 P47239	Morphology	unknown	Labeotropheus trewavasae (species)	Labeotropheus trewavasae (species)		pax7a	Labeotropheus trewavasae (species)	Published - Accepted by Curator
pax7a	Coloration (scales)	Cis-regulatory, Unknown	Labeotropheus trewavasae (species)	Intraspecific	Candidate Gene	Roberts RB; Moore EC; Kocher TD (2017) An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid f[...]	GP00001423	Pax7 P47239	Morphology	unknown	Labeotropheus trewavasae (species)	Labeotropheus trewavasae (species)		pax7a	Labeotropheus trewavasae (species)	Published - Accepted by Curator
pax7a	Coloration (scales)	Cis-regulatory, Unknown	Labeotropheus trewavasae (species)	Intraspecific	Candidate Gene	Roberts RB; Moore EC; Kocher TD (2017) An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid f[...]	GP00001424	Pax7 P47239	Morphology	unknown	Labeotropheus trewavasae (species)	Labeotropheus trewavasae (species)		pax7a	Labeotropheus trewavasae (species)	Published - Accepted by Curator
pdm3	Coloration (female abdomen)	Cis-regulatory, Complex Change	Drosophila serrata (species) D	Intraspecific	Linkage Mapping	Yassin A; Delaney EK; Reddiex AJ ; et al. (2016) The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila[...]	GP00001400	pdm3 A0A0B4LEG2	Morphology	1st intron variant divergent in length and sequence. Dark haplotype contains four tandem sets of three motifs.	Drosophila serrata (species)	Drosophila serrata (species) D		pdm3	Drosophila serrata (species)	Published - Accepted by Curator
pdm3	Coloration (female abdomen)	Cis-regulatory, Unknown	Drosophila kikkawai (species)	Intraspecific	Linkage Mapping	Yassin A; Delaney EK; Reddiex AJ ; et al. (2016) The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila[...]	GP00001401	pdm3 A0A0B4LEG2	Morphology	associated SNPs occur in the intergenic upstream region except one in the second intron	Drosophila kikkawai (species)	Drosophila kikkawai (species)		pdm3	Drosophila kikkawai (species)	Published - Accepted by Curator
pdm3	Coloration (female abdomen)	Unknown, Unknown	Drosophila burlai (species)	Intraspecific	Linkage Mapping	Yassin A; Delaney EK; Reddiex AJ ; et al. (2016) The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila[...]	GP00001402	pdm3 A0A0B4LEG2	Morphology	unknown	Drosophila burlai (species)	Drosophila burlai (species)		pdm3	Drosophila burlai (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001321	peel-1 G5EGC6	Physiology	1bp deletion creating a frameshift starting at amino acid position 43. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001322	peel-1 G5EGC6	Physiology	G>T - glycine to stop codon at position 57. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1/zeel-1	Hybrid incompatibility	Gene Loss, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection. 1 Additional References Seidel HS; Ailion M; Li J (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]	GP00001320	peel-1 G5EGC6	Physiology	19kb deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		peel-1/zeel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
PER36	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Macquet A; Ralet MC; Loudet O ; et al. (2007) A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...] 1 Additional References Kunieda T; Shimada T; Kondo M (2013) Spatiotemporal secretion of PEROXIDASE36 is required for seed coat mucilage extrusion in Arabidopsis[...]	GP00001273	PER36 Q9SD46	Physiology	Tyrosine @position 262bp to a stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		PER36	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Period (per)	Locomotor activity (temperature sensitivity)	Coding, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sawyer LA; Hennessy JM; Peixoto AA ; et al. (1997) Natural variation in a Drosophila clock gene and temperature compensation.	GP00002002	per P07663	Behavior	repeat (Thr-Gly) either 17 times or 20 times within the protein coding sequence	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Period (per)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Period (per)	Diapause	Unknown, Unknown	Pieris napi (species)	Intraspecific	Association Mapping	Pruisscher P; Nylin S; Wheat CW ; et al. (2021) A region of the sex chromosome associated with population differences in diapause induction contains[...] 1 Additional References Pruisscher P; Nylin S; Wheat CW (2021) A region of the sex chromosome associated with population differences in diapause induction contains[...]	GP00002427	per P07663	Physiology	Multiple amino acid differences. Presence of five fixed SNPs between the N and S populations (one intergenic, two intronic and two exonic nonsynonymous substitutions).	Pieris napi (species)	Pieris napi (species)		Period (per)	Pieris napi (species)	Published - Accepted by Curator
PGRP-LC	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sackton TB; Lazzaro BP; Clark AG (2010) Genotype and gene expression associations with immune function in Drosophila.	GP00000861	PGRP-LC Q9GNK5	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		PGRP-LC	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
PHGPx	Xenobiotic resistance (gemcitabine ; female fertility)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	King EG; Kislukhin G; Walters KN ; et al. (2014) Using Drosophila melanogaster to identify chemotherapy toxicity genes.	GP00001405	PHGPx Q8IRD4	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		PHGPx	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Phosphate transporter PHO1	Root growth (allometry of lateral roots)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Rosas U; Cibrian-Jaramillo A; Ristova D ; et al. (2013) Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling [...]	GP00001284	PHO1 Q8S403	Morphology	histidine to tyrosine @position 8388425 in chromosome III	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Phosphate transporter PHO1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome A (PHYA)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Maloof JN; Borevitz JO; Dabi T ; et al. (2001) Natural variation in light sensitivity of Arabidopsis.	GP00000870	PHYA P14712	Physiology	M548T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome A (PHYA)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome B (PHYB)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Filiault DL; Wessinger CA; Dinneny JR ; et al. (2008) Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.	GP00000871	PHYB P14713	Physiology	I143L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome B (PHYB)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome C (PHYC)	Light sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006) The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]	GP00000873	PHYC P14714	Physiology	K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome C (PHYC)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome D (PHYD)	Leaf morphology (increased petiole length) Cotyledon morphology (reduced cotyledon area) Coloration (anthocyanin accumulation in seedling stems) Plant size (diminished effect of end-of-day pulse of far red light on hypocotyl elongation) Plant architecture (decrease in number of rosette leaves at onset of flowering)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Aukerman MJ; Hirschfeld M; Wester L ; et al. (1997) A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome [...]	GP00000874	PHYD P42497	Morphology Morphology Morphology Physiology Morphology	14bp deletion causing premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		phytochrome D (PHYD)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
PigmR	Pathogen resistance (plant fungus pathogen)	Unknown, Unknown	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Deng Y; Zhai K; Xie Z ; et al. (2017) Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance.	GP00001592	Pigm_GM4.7 A0A1P8CYR1	Physiology	unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		PigmR	Oryza sativa rice - (species)	Published - Accepted by Curator
PIK3CG	Hematopoiesis (mean blood platelet volume)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001611	PIK3CG P48736	Physiology	C>G at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		PIK3CG	Homo sapiens human - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000886	Pitx1 P70314	Morphology	488bp promoter region : deletion 1 ; 5 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000887	Pitx1 P70314	Morphology	488bp promoter region : deletion 2 ; 757bp deletion present in the pelvic-reduced BEPA population from Alaska	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000888	Pitx1 P70314	Morphology	488bp promoter region : deletion 3 ; 3.5 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000889	Pitx1 P70314	Morphology	488bp promoter region : deletion 4 ; 757 bp deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000890	Pitx1 P70314	Morphology	488bp promoter region : deletion 5 ; 2 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000891	Pitx1 P70314	Morphology	488bp promoter region : deletion 6 ; 973bp deletion present in the Hump Lake AK pelvic-reduced population (HUMP)	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000892	Pitx1 P70314	Morphology	488bp promoter region : deletion 7 ; 1868bp deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000893	Pitx1 P70314	Morphology	488bp promoter region : deletion 8 ; 8 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000894	Pitx1 P70314	Morphology	488bp promoter region : deletion 9 ; 8 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
plep-1	Male-male copulatory behavior	Coding, SNP	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Noble LM; Chang AS; McNelis D ; et al. (2015) Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.	GP00000897	plep-1 A0A0K3AR66	Behavior	V278D	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		plep-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
plg-1	Copulatory plug	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Palopoli MF; Rockman MV; TinMaung A ; et al. (2008) Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.	GP00000898		Physiology	insertion of transposable element in an exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		plg-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Pm3	Pathogen resistance	Coding, SNP	Triticum aestivum bread wheat - (species)	Intraspecific	Linkage Mapping	Yahiaoui N; Kaur N; Keller B (2009) Independent evolution of functional Pm3 resistance genes in wild tetraploid wheat and domesticated b[...] 1 Additional References Yahiaoui N; Brunner S; Keller B (2006) Rapid generation of new powdery mildew resistance genes after wheat domestication.	GP00000899	PM3 C1K3M2	Physiology	Various substitution haplotypes - exact causing amino acid change(s) unknown - in hexaploid bread wheat one amino acid change in a solvent‐exposed residue of LRR27 (E1334 to V1334) was sufficient to convert the susceptible Pm3CS into a functional resistance allele (Yahiaoui et al., 2006).	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Pm3	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
PMEI6	Mucilage (seeds)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis. 1 Additional References Saez-Aguayo S; Ralet MC; Berger A (2013) PECTIN METHYLESTERASE INHIBITOR6 promotes Arabidopsis mucilage release by limiting methylesterificat[...]	GP00001272	AXX17_At2g45450 A0A178VVA1	Physiology	frameshift mutation due to a 1-bp insertion 581 bp after the ATG codon that changed amino acids 194 to 205 followed by the introduction of a stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		PMEI6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
poils au dos (pad)	Bristle number (thorax)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Gibert JM; Marcellini S; David JR ; et al. (2005) A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription [...]	GP00000915	pad Q9VEW6	Morphology	29bp deletion N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		poils au dos (pad)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Pore-forming toxin-like (PFT)	Pathogen resistance (Fusarium)	Gene Loss, Indel N	Triticum aestivum bread wheat - (species)	Intraspecific	Linkage Mapping	Rawat N; Pumphrey MO; Liu S ; et al. (2016) Wheat Fhb1 encodes a chimeric lectin with agglutinin domains and a pore-forming toxin-like domain co[...]	GP00001563	Q4JEV5	Physiology	PFT gene is present and constitutively expressed in resistant line and absent in susceptible line N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Pore-forming toxin-like (PFT)	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
pot-2	Telomere length	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Cook DE; Zdraljevic S; Tanny RE ; et al. (2016) The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.	GP00001317	pot-2 O45595	Physiology	Phenylalanine-to-isoleucine (F68I) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		pot-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
PPAR-alpha	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 1 Additional References Bigham A; Bauchet M; Pinto D (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...]	GP00000917	PPARA Q07869	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		PPAR-alpha	Homo sapiens human - (species)	Published - Accepted by Curator
PPAR-delta	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	N'Diaye A; Chen GK; Palmer CD ; et al. (2011) Identification, replication, and fine-mapping of Loci associated with adult height in individuals of[...] 1 Additional References Lango Allen H; Estrada K; Lettre G (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height.	GP00000918	PPARD Q03181	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		PPAR-delta	Homo sapiens human - (species)	Published - Accepted by Curator
PPAR-gamma	Fertility	Cis-regulatory, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Hoedjes KM; Kostic H; Flatt T ; et al. (2023) A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.	GP00002664	Eip75B P17672	Physiology	This SNP is biallelic with the “T” variant being more common in the late-reproducing long-lived populations (average frequency: 0.84 “T” / 0.16 “G”) as compared to the early-reproducing populations (average frequency: 0.52 “T” / 0.48 “G”).	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		PPAR-gamma	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ppw-1	Resistance to dsRNA	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Tijsterman M; Okihara KL; Thijssen K ; et al. (2002) PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]	GP00000921		Physiology	1bp deletion resulting in stop codon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		ppw-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Prdm9	Hybrid incompatibility (F1 male sterility) Recombination rate (use of recombination hotspots)	Unknown, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Mihola O; Trachtulec Z; Vlcek C ; et al. (2009) A mouse speciation gene encodes a meiotic histone H3 methyltransferase. 2 Additional References Baudat F; Buard J; Grey C (2010) PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Flachs P; Mihola O; Simeček P (2012) Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.	GP00000922	Prdm9 Q96EQ9	Physiology Physiology	possible dosage difference (number of gene copies) interacting with an allele that affects post-transcriptional stability	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Prdm9	Mus musculus house mouse - (species)	Published - Accepted by Curator
Prdm9	Recombination rate (use of recombination hotspots)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Berg IL; Neumann R; Sarbajna S ; et al. (2011) Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots [...]	GP00000923	Prdm9 Q96EQ9	Physiology	Various haplotypes	Homo sapiens human - (species)	Homo sapiens human - (species)		Prdm9	Homo sapiens human - (species)	Published - Accepted by Curator
PRKCD	Pathogen resistance	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001381	PRKCD Q05655	Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		PRKCD	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Proline specific permease PUT4	Nitrogen use (growth rate on proline)	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001501	PUT4 P15380	Physiology	several synonymous and promoter mutations	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Proline specific permease PUT4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
prolyl endopeptidase (PREP)	Coloration (scales)	Cis-regulatory, Unknown	Uta stansburiana (species) D	Intraspecific	Association Mapping	Corl A; Bi K; Luke C ; et al. (2018) The Genetic Basis of Adaptation following Plastic Changes in Coloration in a Novel Environment.	GP00002108	PREP P48147	Morphology	no coding mutation associated with the phenotype - 2 differentiated SNPs in introns and one is a synonymous change.	Uta stansburiana (species)	Uta stansburiana (species) D		prolyl endopeptidase (PREP)	Uta stansburiana (species)	Published - Accepted by Curator
prophenoloxidase 1 (PPO1)	Enzymatic activity	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Asada N (1997) Genetic variants affecting phenoloxidase activity in Drosophila melanogaster.	GP00002001		Physiology	Exact causing mutation(s) unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		prophenoloxidase 1 (PPO1)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A)	Coloration (scales)	Cis-regulatory, Unknown	Uta stansburiana (species) D	Intraspecific	Association Mapping	Corl A; Bi K; Luke C ; et al. (2018) The Genetic Basis of Adaptation following Plastic Changes in Coloration in a Novel Environment.	GP00002109	Prkar1a Q9DBC7	Morphology	no coding mutation associated with the phenotype - one differentiated SNP in an intron in the 5' UTR	Uta stansburiana (species)	Uta stansburiana (species) D		protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A)	Uta stansburiana (species)	Published - Accepted by Curator
protein phosphatase	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001534	PF3D7_1012700 Q8IJR8	Physiology	p.Val1157Leu	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		protein phosphatase	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
protoporphyrinogen oxidase (PPO2 = PPX2L)	Xenobiotic resistance (herbicides)	Coding, Deletion	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt WL; Hager AG; McCormick JS ; et al. (2006) A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase.	GP00000929	PPX2L Q0NZW6	Physiology	3bp deletion; deletion of G210	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		protoporphyrinogen oxidase (PPO2 = PPX2L)	Amaranthus tuberculatus (species)	Published - Accepted by Curator
PSMD13	Hematopoiesis (mean blood platelet volume)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001615	PSMD13 Q9UNM6	Physiology	A>G at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		PSMD13	Homo sapiens human - (species)	Published - Accepted by Curator
PSST	Xenobiotic resistance (METI-I acaricide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Bajda S; Dermauw W; Panteleri R ; et al. (2017) A mutation in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Tetranychus urti[...]	GP00002635	ND-20 Q9VXK7	Physiology	H92R	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		PSST	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
PSST	Xenobiotic resistance (METI-I acaricide)	Coding, SNP	Panonychus citri citrus red mite - (species) D	Intraspecific	Candidate Gene	Alavijeh ES; Khajehali J; Snoeck S ; et al. (2020) Molecular and genetic analysis of resistance to METI-I acaricides in Iranian populations of the citr[...]	GP00002636	ND-20 Q9VXK7	Physiology	H92R	Panonychus citri citrus red mite - (species)	Panonychus citri citrus red mite - (species) D		PSST	Panonychus citri citrus red mite - (species)	Published - Accepted by Curator
PTPN1	High-altitude adaptation	Coding, SNP	Locusta migratoria migratory locust - (species) D	Intraspecific	Association Mapping	Ding D; Liu G; Hou L ; et al. (2018) Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan m[...]	GP00002668	P18031NULL	Physiology	one nonsynonymous mutation (c.1046A>T) in PTPN1 in Tibetan locusts which encodes the amino acid substitution p.Asn349Ile at the proline (Pro)-rich domain of PTP1B.	Locusta migratoria migratory locust - (species)	Locusta migratoria migratory locust - (species) D		PTPN1	Locusta migratoria migratory locust - (species)	Published - Accepted by Curator
PVX_084940	Xenobiotic resistance (multiresistance to antimalarial drugs)	Unknown, Unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001487	PVX_084940 A5K0T0	Physiology	unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species)		PVX_084940	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
PVX_101445	Xenobiotic resistance (chloroquine)	Gene Amplification, Insertion	Plasmodium vivax malaria parasite P. vivax - (species) D	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001483	PVX_101445 A5K913	Physiology	3 kb duplication on chromosome 14 that includes PVX_101445	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species) D		PVX_101445	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
R2R3-Myb	Coloration (flowers)	Cis-regulatory, Unknown	Phlox drummondii (species)	Intraspecific	Linkage Mapping	Hopkins R; Rausher MD (2011) Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii.	GP00000948	H8ZS70	Morphology	unknown	Phlox drummondii (species)	Phlox drummondii (species)		R2R3-Myb	Phlox drummondii (species)	Published - Accepted by Curator
RAC1	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Borhan MH; Holub EB; Beynon JL ; et al. (2004) The arabidopsis TIR-NB-LRR gene RAC1 confers resistance to Albugo candida (white rust) and is depend[...]	GP00000949	ARAC3 Q38912	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RAC1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RALY (hnRNP associated with lethal yellow)	Coloration (coat)	Cis-regulatory, Insertion	Canis lupus gray wolf - (species) D	Intraspecific	Association Mapping	Dreger DL; Parker HG; Ostrander EA ; et al. (2013 May-Jun) Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in [...]	GP00001366	RALY Q9UKM9	Morphology	16 bpduplication g.1875_1890dupCCCCAGGTCAGAGTTT in intron	Canis lupus gray wolf - (species)	Canis lupus gray wolf - (species) D		RALY (hnRNP associated with lethal yellow)	Canis lupus gray wolf - (species)	Published - Accepted by Curator
RAS1	Salt tolerance Abscisic acid sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ren Z; Zheng Z; Chinnusamy V ; et al. (2010) RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis.	GP00000953	RAS1 O04515	Physiology Physiology	Premature stop codon; Lys>STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RAS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RCR3	Pathogen resistance	Coding, SNP	Solanum peruvianum (species)	Intraspecific	Candidate Gene	Hörger AC; Ilyas M; Stephan W ; et al. (2012) Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathog[...]	GP00000963	Rcr3 Q8S333	Physiology	Candidate amino acid changes are I206K and/or Q222E and/or S330A	Solanum peruvianum (species)	Solanum peruvianum (species)		RCR3	Solanum peruvianum (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001246	At4g11040 Q9T010	Physiology	G892A	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Gene Loss, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001247	At4g11040 Q9T010	Physiology	gene loss: -5.7KB at position -4.38KB N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001248	At4g11040 Q9T010	Physiology	-23bp at position 1371 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001249	At4g11040 Q9T010	Physiology	-25bp at position 25 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001250	At4g11040 Q9T010	Physiology	-50bp at position 50; -390bp at position 504 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001251	At4g11040 Q9T010	Physiology	-13bp at position 1440 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001252	At4g11040 Q9T010	Physiology	-2bp at position 1456 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001253	At4g11040 Q9T010	Physiology	-4bp at position 1391 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001254	At4g11040 Q9T010	Physiology	-16bp at position 1054 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001255	At4g11040 Q9T010	Physiology	-19bp at position 594 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001256	At4g11040 Q9T010	Physiology	-2bp at position 606 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001257	At4g11040 Q9T010	Physiology	-4bp at position 11 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001258	At4g11040 Q9T010	Physiology	C684A which causes C135* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001259	At4g11040 Q9T010	Physiology	4 amino acid changes: N45K; G54R; T55K; E208A - the effect of each single amino acid change has not been tested N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001260	At4g11040 Q9T010	Physiology	-1bp at position 498 causing premature STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001261	At4g11040 Q9T010	Physiology	-1bp at position 498 causing premature STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ref(2)P	Pathogen resistance (sigma virus)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Dru P; Bras F; Dezélée S ; et al. (1993) Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...] 2 Additional References Carré-Mlouka A; Gaumer S; Gay P (2007) Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo stu[...] Wyers F; Petitjean AM; Dru P (1995) Localization of domains within the Drosophila Ref(2)P protein involved in the intracellular control [...]	GP00001994	ref(2)P P14199	Physiology	Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pn strains. Exact causing mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		ref(2)P	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ref(2)P	Pathogen resistance (sigma virus)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Dru P; Bras F; Dezélée S ; et al. (1993) Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...] 2 Additional References Carré-Mlouka A; Gaumer S; Gay P (2007) Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo stu[...] Wyers F; Petitjean AM; Dru P (1995) Localization of domains within the Drosophila Ref(2)P protein involved in the intracellular control [...]	GP00001995	ref(2)P P14199	Physiology	Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pp strains. Exact causing mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		ref(2)P	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Regulator of G-protein signaling 2 (RGS2)	Anxiety	Unknown, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Yalcin B; Willis-Owen SA; Fullerton J ; et al. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mic[...]	GP00000967	Rgs2 O08849	Behavior	unknown	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Regulator of G-protein signaling 2 (RGS2)	Mus musculus house mouse - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Thompson M; Shotkoski F; ffrench-Constant R (1993) Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]	GP00000968	Rdl P25123	Physiology	Ala302Ser	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		resistance to dieldrin	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species) D	Intraspecific	Candidate Gene	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000969	Rdl P25123	Physiology	Ala302Ser	Anopheles arabiensis (species)	Anopheles arabiensis (species) D		resistance to dieldrin	Anopheles arabiensis (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000970	Rdl P25123	Physiology	Ala302Gly	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		resistance to dieldrin	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Alon M; Alon F; Nauen R (2008) Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associat[...]	GP00000971	Rdl P25123	Physiology	2 mutations	Bemisia tabaci (species)	Bemisia tabaci (species) D		resistance to dieldrin	Bemisia tabaci (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Kaku K; Matsumura F (1994) Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]	GP00000972	Rdl P25123	Physiology	Ala302Ser	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		resistance to dieldrin	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]	GP00000973	Rdl P25123	Physiology	Ala302Ser	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		resistance to dieldrin	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993) A point mutation in a Drosophila GABA receptor confers insecticide resistance. 2 Additional References Lee HJ; Rocheleau T; Zhang HG (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000974	Rdl P25123	Physiology	Ala302Ser - G9155164T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Rdl P25123	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Hypothenemus hampei coffee berry borer - (species) D	Intraspecific	Candidate Gene	Brun LO; Stuart J; Gaudichon V ; et al. (1995) Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...] 2 Additional References Navarro Lucio; Gongora Carmenza; Benavides Pablo (2010 ) Single nucleotide polymorphism detection at the Hypothenemus hampei Rdl gene by allele-specific PCR [...] Steichen JC; Brun LO (1994 ) A molecular diagnostic for endosulfan insecticide resistance in the coffee berry borer Hypothenemus [...]	GP00000977	Rdl P25123	Physiology	Ala302Ser	Hypothenemus hampei coffee berry borer - (species)	Hypothenemus hampei coffee berry borer - (species) D		resistance to dieldrin	Hypothenemus hampei coffee berry borer - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000978	Rdl P25123	Physiology	Ala302Ser	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		resistance to dieldrin	Musca domestica house fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anthony N; Unruh T; Ganser D ; et al. (1998) Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.	GP00000979	Rdl P25123	Physiology	Ala302Gly	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		resistance to dieldrin	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Periplaneta americana American cockroach - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000980	Rdl P25123	Physiology	Ala302Ser	Periplaneta americana American cockroach - (species)	Periplaneta americana American cockroach - (species) D		resistance to dieldrin	Periplaneta americana American cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Tribolium castaneum red flour beetle - (species)	Intraspecific	Candidate Gene	Miyazaki M; Matsumura F; Beeman RW (1995) DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...] 1 Additional References Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000981	Rdl P25123	Physiology	Ala302Ser	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species)		resistance to dieldrin	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Le Goff G; Hamon A; Bergé JB ; et al. (2005) Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]	GP00001981	Rdl P25123	Physiology	2 mutations	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	ffrench-Constant RH; Steichen JC; Rocheleau TA ; et al. (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00001982	Rdl P25123	Physiology	Ala301Ser - The lesion in the RdlMD-RR allele has been described as A302S in print but the amino acid replacement is actually A301S.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Remnant EJ; Good RT; Schmidt JM ; et al. (2013) Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster.	GP00002452	Rdl P25123	Physiology	113-kb duplication containing one WT copy of Rdl and a second copy with two point mutations: an Ala(301) to Ser resistance mutation and Met(360) to Ile replacement. Individuals with this duplication exhibit intermediate dieldrin resistance compared with single copy Ser(301) homozygotes and reduced temperature sensitivity and altered RNA editing associated with the resistant allele. Ectopic recombination between Roo transposable elements is involved in generating this genomic rearrangement. The duplication phenotypes were confirmed by construction of a transgenic artificial duplication integrating the 55.7-kb Rdl locus with a Ser(301) change into an Ala(301) background.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Wondji CS; Dabire RK; Tukur Z ; et al. (2011) Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the ma[...]	GP00002557	Rdl P25123	Physiology	2 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D		resistance to dieldrin	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Domingues LN; Guerrero FD; Becker ME ; et al. (2013) Discovery of the Rdl mutation in association with a cyclodiene resistant population of horn flies, H[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002558	Rdl P25123	Physiology	Ala301Ser	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		resistance to dieldrin	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Tantely ML; Tortosa P; Alout H ; et al. (2010) Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002559	Rdl P25123	Physiology	Ala301Ser	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		resistance to dieldrin	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Tantely ML; Tortosa P; Alout H ; et al. (2010) Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002560	Rdl P25123	Physiology	Ala301Ser	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		resistance to dieldrin	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Nakao T; Kawase A; Kinoshita A ; et al. (2011) The A2'N mutation of the RDL gamma-aminobutyric acid receptor conferring fipronil resistance in Laod[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002561	Rdl P25123	Physiology	A301N	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D		resistance to dieldrin	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Diabrotica virgifera (species) D	Intraspecific	Candidate Gene	Wang H; Coates BS; Chen H ; et al. (2013) Role of a γ-aminobutryic acid (GABA) receptor mutation in the evolution and spread of Diabrotica vir[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002566	Rdl P25123	Physiology	A301S	Diabrotica virgifera (species)	Diabrotica virgifera (species) D		resistance to dieldrin	Diabrotica virgifera (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Hope M; Menzies M; Kemp D (2010) Identification of a dieldrin resistance-associated mutation in Rhipicephalus (Boophilus) microplus ([...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002567	Rdl P25123	Physiology	T305L	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		resistance to dieldrin	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
resistant to methyl viologen 1 (RMV1)	Polyamine uptake	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Fujita M; Fujita Y; Iuchi S ; et al. (2012) Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis.	GP00000982	RMV1 Q9FFL1	Physiology	Ile377Phe N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		resistant to methyl viologen 1 (RMV1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Rhg1	Pathogen resistance (cyst nematode)	Gene Amplification, Complex Change	Glycine max soybean - (species)	Intraspecific	Linkage Mapping	Cook DE; Lee TG; Guo X ; et al. (2012) Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean.	GP00000985	rhg1s Q8L3Y5	Physiology	Copy number Variant : 10-tandem copies of the gene cluster in resistant strains ; the 3 dissimilar genes participate to resistance	Glycine max soybean - (species)	Glycine max soybean - (species)		Rhg1	Glycine max soybean - (species)	Published - Accepted by Curator
Rhg1	Pathogen resistance (cyst nematode)	Cis-regulatory, Insertion	Glycine max soybean - (species) D	Intraspecific	Linkage Mapping	Bayless AM; Zapotocny RW; Han S ; et al. (2019) The rhg1-a (Rhg1 low-copy) nematode resistance source harbors a copia-family retrotransposon within [...]	GP00002049	rhg1s Q8L3Y5	Physiology	insertion of a copia retrotransposon within the gene Rhg1 Glyma.18G022500 (α-SNAP-encoding). This transposable element is intact and resides within intron 1; anti-sense to the rhg1-a α-SNAP open reading frame.	Glycine max soybean - (species)	Glycine max soybean - (species) D		Rhg1	Glycine max soybean - (species)	Published - Accepted by Curator
RHO2	Temperature tolerance / virulence	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000986	RHO2 P06781	Physiology	3'UTR polymorphism	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		RHO2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RLM1	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Staal J; Kaliff M; Bohman S ; et al. (2006) Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]	GP00000991	RLM1A F4I594	Physiology	Digenic; deletion of gene1 and premature stop codons in gene2 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RLM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RLM2 cluster	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Staal J; Kaliff M; Bohman S ; et al. (2006) Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]	GP00000992	RLM1B Q9CAK1	Physiology	the locus contains two paralogues; one of which is deleted and the other pseudogenized in Ler-0 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RLM2 cluster	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RLM3	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Staal J; Kaliff M; Dewaele E ; et al. (2008) RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fun[...]	GP00000993	RLM3 Q9FT77	Physiology	gene deletion N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RLM3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RME1 [possible pseudo-replicate of laboratory strain entry]	Sporulation efficiency	Cis-regulatory, Deletion	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00000995	RME1 P32338	Physiology	single nucleotide deletion in promoter region	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RME1 [possible pseudo-replicate of laboratory strain entry]	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RnrS	Xenobiotic resistance (gemcitabine ; female fertility)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	King EG; Kislukhin G; Walters KN ; et al. (2014) Using Drosophila melanogaster to identify chemotherapy toxicity genes.	GP00001404	RnrS P48592	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		RnrS	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Root System Architecture 1	Root growth (allometry of lateral roots)	Cis-regulatory, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Rosas U; Cibrian-Jaramillo A; Ristova D ; et al. (2013) Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling [...]	GP00001285	Root System Architecture 1 F4JL94	Morphology	348bp upstream of the 5'UTR	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Root System Architecture 1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ROSEA	Coloration (flowers)	Unknown, Unknown	Antirrhinum majus snapdragon - (species)	Intraspecific	Linkage Mapping	Whibley AC; Langlade NB; Andalo C ; et al. (2006) Evolutionary paths underlying flower color variation in Antirrhinum.	GP00000997	ROS1 Q2VAZ7	Morphology	Not identified	Antirrhinum majus snapdragon - (species)	Antirrhinum majus snapdragon - (species)		ROSEA	Antirrhinum majus snapdragon - (species)	Published - Accepted by Curator
RPM1	Pathogen resistance	Gene Loss, Indel N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Grant MR; McDowell JM; Sharpe AG ; et al. (1998) Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis. 2 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Stahl EA; Dwyer G; Mauricio R (1999) Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis.	GP00001000	RPM1 Q39214	Physiology	3.7kb indel with a null-state in the sensitive strains N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPM1	Pathogen resistance	Gene Loss, Complex Change N	Brassica napus rape - (species)	Intraspecific	Linkage Mapping	Grant MR; McDowell JM; Sharpe AG ; et al. (1998) Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis.	GP00001001	RPM1 Q39214	Physiology	deletion N	Brassica napus rape - (species)	Brassica napus rape - (species)		RPM1	Brassica napus rape - (species)	Published - Accepted by Curator
RPP1	Hybrid incompatibility	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Alcázar R; von Reth M; Bautor J ; et al. (2014) Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...] 1 Additional References Alcázar R; García AV; Kronholm I (2010) Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...]	GP00001281	RPP1 F4J339	Physiology	complex	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1	Hybrid incompatibility	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Alcázar R; von Reth M; Bautor J ; et al. (2014) Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...] 1 Additional References Alcázar R; García AV; Kronholm I (2010) Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...]	GP00001282	RPP1 F4J339	Physiology	complex	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsA	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001002	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1-WsA	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsB	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001003	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1-WsB	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsC	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001004	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1-WsC	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP2A-RPP2B	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sinapidou E; Williams K; Nott L ; et al. (2004) Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in A[...]	GP00001006	RPP2A P51407	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP2A-RPP2B	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP4	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	van der Biezen EA; Freddie CT; Kahn K ; et al. (2002) Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]	GP00001007	RPP4 F4JNA9	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP5	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	van der Biezen EA; Freddie CT; Kahn K ; et al. (2002) Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001008	RPP5 F4JNB7	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP5	Pathogen resistance	Gene Amplification, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Parker JE; Coleman MJ; Szabò V ; et al. (1997) The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 re[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001009	RPP5 F4JNB7	Physiology	Partial duplication sufficient to increase resistance	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP8	Pathogen resistance	Coding, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	McDowell JM; Dhandaydham M; Long TA ; et al. (1998) Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resi[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001010	RPP8 Q8W4J9	Physiology	Chimeric fusion of two paralogues followed by coding divergence	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP8	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Mindrinos M; Katagiri F; Yu GL ; et al. (1994) The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site [...]	GP00001011	RPS2 Q42484	Physiology	10bp insertion close to the 5' end causing a frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Caicedo AL; Schaal BA; Kunkel BN (1999) Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.	GP00001012	RPS2 Q42484	Physiology	W235* due to G704A N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS4	Pathogen resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Narusaka M; Shirasu K; Noutoshi Y (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.	GP00001013	RPS4 Q9XGM3	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RPS4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS5	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Henk AD; Warren RF; Innes RW (1999) A new Ac-like transposon of Arabidopsis is associated with a deletion of the RPS5 disease resistance[...] 1 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.	GP00001014	RPS5 O64973	Physiology	Deletion N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPS5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RREB1	Body fat distribution (visceral)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001555	RREB1 Q92766	Physiology	C>G in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		RREB1	Homo sapiens human - (species)	Published - Accepted by Curator
RRS1	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Birker D; Heidrich K; Takahara H (2009) A locus conferring resistance to Colletotrichum higginsianum is shared by four geographically distin[...]	GP00001015	RRS1 P0DKH5	Physiology	Premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RRS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RSF1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00001016	HFR1 Q9FE22	Physiology	D181G	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		RSF1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Troczka B; Zimmer CT; Elias J ; et al. (2012) Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...] 2 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] Guo L; Wang Y; Zhou X (2014) Functional analysis of a point mutation in the ryanodine receptor of Plutella xylostella (L.) associ[...]	GP00002433	RyR Q24498	Physiology	G4946E	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Troczka B; Zimmer CT; Elias J ; et al. (2012) Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002434	RyR Q24498	Physiology	G4946E due to GGG>GAA	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Steinbach D; Moritz G ; et al. (2017) Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002435	RyR Q24498	Physiology	G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Steinbach D; Moritz G ; et al. (2017) Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002436	RyR Q24498	Physiology	G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Douris V; Papapostolou KM; Ilias A ; et al. (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002438	RyR Q24498	Physiology	G4903V corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Douris V; Papapostolou KM; Ilias A ; et al. (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] 1 Additional References Wang X; Cao X; Jiang D (2020) CRISPR/Cas9 mediated ryanodine receptor I4790M knockin confers unequal resistance to diamides in Plu[...]	GP00002439	RyR Q24498	Physiology	I4790M	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Guo L; Liang P; Zhou X ; et al. (2014) Novel mutations and mutation combinations of ryanodine receptor in a chlorantraniliprole resistant p[...]	GP00002605	RyR Q24498	Physiology	E1338D Q4594L I4790M)in highly conserved regions of RyR.	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Gong W; Yan HH; Gao L ; et al. (2014) Chlorantraniliprole resistance in the diamondback moth (Lepidoptera: Plutellidae).	GP00002609	RyR Q24498	Physiology	14 amino acid (Q4546-S4559) deletion. RyR transcript levels are lower in resistant strains than in susceptible strains. N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Yao R; Zhao DD; Zhang S ; et al. (2017) Monitoring and mechanisms of insecticide resistance in Chilo suppressalis (Lepidoptera: Crambidae), [...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002626	RyR Q24498	Physiology	G4946E	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D		RYR	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Wei Y; Yan R; Zhou Q ; et al. (2019) Monitoring and Mechanisms of Chlorantraniliprole Resistance in Chilo suppressalis (Lepidoptera: Cram[...]	GP00002627	RyR Q24498	Physiology	I4758M	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D		RYR	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Candidate Gene	Zuo YY; Ma HH; Lu WJ ; et al. (2020) Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide[...] 2 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] Kim Juil; Nam Hwa Yeun; Kwon Min (2021 ) Novel diamide resistance-linked mutation in Korean Spodoptera exigua and a LAMP assay based on a mut[...]	GP00002633	RyR Q24498	Physiology	I4743M - corresponds to I4790M in PxRyR	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		RYR	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
S locus supergene (GLO/CFB Cluster)	Flower morphology (heterostyly)	Other, Complex Change	Primula vulgaris (species)	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001392		Morphology	Absence/presence of a supergene constituted by a cluster of 6 genes	Primula vulgaris (species)	Primula vulgaris (species)		S locus supergene (GLO/CFB Cluster)	Primula vulgaris (species)	Published - Accepted by Curator
SAP-2	Xenobiotic resistance (insecticide; pyrethroid)	Cis-regulatory, Unknown	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Ingham VA; Anthousi A; Douris V ; et al. (2020) A sensory appendage protein protects malaria vectors from pyrethroids.	GP00002432	SAP-2 Q6H8Z3	Physiology	The gene is highly overexpressed in the appendages of pyrethroid-resistant mosquitoes and its expression is further induced by insecticide exposure. Silencing of SAP2 almost completely restored susceptibility to the pyrethroid deltamethrin and also significantly increased the susceptibility to the other two pyrethroids (permethrin and alpha-cypermethrin).	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		SAP-2	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
SBNO1	Head size	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Taal HR; Pourcain BS; Thiering E ; et al. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference.	GP00001023	SBNO1 A3KN83	Morphology	Ser729Asn	Homo sapiens human - (species)	Homo sapiens human - (species)		SBNO1	Homo sapiens human - (species)	Published - Accepted by Curator
scabrous	Bristle number (abdomen)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Lai C; Lyman RF; Long AD ; et al. (1994) Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Droso[...]	GP00001024	sca P21520	Morphology	unknown; but different sites than for thorax association	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		scabrous	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
scabrous	Bristle number (thorax)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Lai C; Lyman RF; Long AD ; et al. (1994) Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Droso[...]	GP00001025	sca P21520	Morphology	unknown; but different sites than for abdomen association	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		scabrous	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
SCARB1	Carotenoid content	Coding, SNP N	Serinus canaria common canary - (species) D	Intraspecific	Linkage Mapping	Toomey MB; Lopes RJ; Araújo PM ; et al. (2017) High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.	GP00001681	Scarb1 Q61009	Morphology	T>G nucleotide substitution in the splice-donor site immediately downstream of exon 4 of the SCARB1 gene. This mutation results in abnormal splicing; with the most abundant transcript lacking exon 4. Isoform 4 of SCARB1; the most abundant transcript isoform in the white recessive canary; is predicted to lack 68 amino acids; a deficiency which disrupts SCARB1 protein function. N	Serinus canaria common canary - (species)	Serinus canaria common canary - (species) D		SCARB1	Serinus canaria common canary - (species)	Published - Accepted by Curator
scd-2	Diapause	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Reiner DJ; Ailion M; Thomas JH ; et al. (2008) C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]	GP00001026	scd-2 O76411	Physiology	Gly985Arg	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		scd-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Mya arenaria (species) D	Intraspecific	Candidate Gene	Bricelj VM; Connell L; Konoki K ; et al. (2005) Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.	GP00000721	SCN4A P35499	Physiology	E945D	Mya arenaria (species)	Mya arenaria (species) D		SCN4A (Nav1.4)	Mya arenaria (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000730	SCN4A P35499	Physiology	G1566A in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000731	SCN4A P35499	Physiology	I1561V in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000732	SCN4A P35499	Physiology	I1556L and/or D1568N and/or G1569V	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCR	Self-incompatibility (loss)	Coding, Inversion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Tsuchimatsu T; Suwabe K; Shimizu-Inatsugi R ; et al. (2010) Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene. 1 Additional References Shimizu KK; Shimizu-Inatsugi R; Tsuchimatsu T (2008) Independent origins of self-compatibility in Arabidopsis thaliana.	GP00001271	SCRA P0CG07	Physiology	213 bp inversion causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		SCR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Serine/threonine protein kinase RIM15	Nitrogen use (growth efficiency)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001500	RIM15 P43565	Physiology	2 bp insertion 459_460insCA shifting the reading frame to cause an early stop codon (null allele) N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Serine/threonine protein kinase RIM15	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SG3/At4g30720	Growth (shoots)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Vlad D; Rappaport F; Simon M ; et al. (2010) Gene transposition causing natural variation for growth in Arabidopsis thaliana.	GP00001036	PDE327 F4JQE2	Physiology	Premature stop codon at the SG3 locus in Bur-0 (a 1bp deletion in exon four of At4g30720 results in a frame shift; predicting a premature stop codon which terminates the ORF after 5 amino acids); but in this accession this gene has a functional copy at a N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		SG3/At4g30720	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SIR2	Longevity	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00001054	SIR2 P06700	Physiology	1 to 5 amino-acid substitutions	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		SIR2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SLB1/2	Pathogen resistance (Root parasitic plant) (root parasitic plant)	Gene Loss, Deletion N	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Cardoso C; Zhang Y; Jamil M ; et al. (2014) Natural variation of rice strigolactone biosynthesis is associated with the deletion of two MAX1 ort[...]	GP00001631	Os01g0700900 M9R6D3	Physiology	deletion of 2 cytochrome P450 genes (Os010700900 & Os01g0701400) N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		SLB1/2	Oryza sativa rice - (species)	Published - Accepted by Curator
SLC24A5 (NCKX5)	Coloration (eyes; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lamason RL; Mohideen MA; Mest JR ; et al. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. 5 Additional References Beleza S; Johnson NA; Candille SI (2013) Genetic architecture of skin and eye color in an African-European admixed population. Wakamatsu K; Kavanagh R; Kadekaro AL (2006) Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as[...] Ginger RS; Askew SE; Ogborne RM (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activ[...] Quillen EE; Bauchet M; Bigham AW (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...] Basu Mallick C; Iliescu FM; Möls M (2013) The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.	GP00001056	Slc24a5 Q8C261	Morphology	Ala111Thr	Homo sapiens human - (species)	Homo sapiens human - (species)		SLC24A5 (NCKX5)	Homo sapiens human - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (eyes; hair; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Graf J; Hodgson R; van Daal A (2005) Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation varia[...] 3 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...] Quillen EE; Bauchet M; Bigham AW (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...] Cook AL; Chen W; Thurber AE (2009) Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5[...]	GP00001061	SLC45A2 Q9UMX9	Morphology	Phe374Leu	Homo sapiens human - (species)	Homo sapiens human - (species)		SLC45A2=MATP	Homo sapiens human - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat)	Coding, SNP	Panthera tigris tiger - (species) D	Intraspecific	Association Mapping	Xu X; Dong GX; Hu XS ; et al. (2013) The genetic basis of white tigers.	GP00001063	SLC45A2 Q9UMX9	Morphology	A477V	Panthera tigris tiger - (species)	Panthera tigris tiger - (species) D		SLC45A2=MATP	Panthera tigris tiger - (species)	Published - Accepted by Curator
SlMYBATV	Coloration (anthocyanin accumulation in fruits)	Coding, Insertion N	Solanum cheesmaniae (species) D	Intraspecific	Linkage Mapping	Cao X; Qiu Z; Wang X ; et al. (2017) A putative R3 MYB repressor is the candidate gene underlying atroviolacium, a locus for anthocyanin [...]	GP00001906	CPC O22059	Morphology; Physiology	SlMYBATV encodes a R3 MYB transcription factor. 4-bp insertion predicted to result in a frame-shift that would alter the protein sequence from amino-acid position 20 onwards by inducing premature termination of translation including the R3/bHLH-binding domain N	Solanum lycopersicum tomato - (species)	Solanum cheesmaniae (species) D		SlMYBATV	Solanum cheesmaniae (species)	Published - Accepted by Curator
slowpoke (slo)	Courtship song (sine song frequency)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Ding Y; Berrocal A; Morita T ; et al. (2016) Natural courtship song variation caused by an intronic retroelement in an ion channel gene.	GP00001066	slo Q03720	Behavior	6.7kb "Shelder" retroelement insertion in slowpoke intron; with effect on splicing	Drosophila simulans (species)	Drosophila simulans (species) D		slowpoke (slo)	Drosophila simulans (species)	Published - Accepted by Curator
smooth	Bristle number (abdomen)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	zur Lage P; Shrimpton AD; Flavell AJ ; et al. (1997) Genetic and molecular analysis of smooth, a quantitative trait locus affecting bristle number in Dro[...]	GP00001996		Morphology	exact causing mutation(s) unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		smooth	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
SOD1	Xenobiotic resistance (paraquat)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Tsakas SC; Loukas M ; et al. (2001) Low-activity allele of copper-zinc superoxide dismutase (CuZnSOD) in Drosophila increases paraquat g[...]	GP00001985	Sod1 P61851	Physiology	Insertion of a 0.68kb truncated P-element 47bp downstream of the transcription start site.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		SOD1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
SOD3	Oxidative stress resistance Blood pressure	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001380	SOD3 P08294	Physiology Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		SOD3	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Sox5/6	Coloration (wing; mimicry)	Cis-regulatory, Unknown	Hypolimnas misippus (species)	Intraspecific	Association Mapping	VanKuren NW; Massardo D; Nallu S ; et al. (2019) Butterfly Mimicry Polymorphisms Highlight Phylogenetic Limits of Gene Reuse in the Evolution of Dive[...]	GP00002429		Morphology	A 10 kb intergenic region located 48kb upstream of the Sox5/6 gene is strongly associated with the wing phenotype. This cis-regulatory change may also affect another neighboring gene, such as pink.	Hypolimnas misippus (species)	Hypolimnas misippus (species)		Sox5/6	Hypolimnas misippus (species)	Published - Accepted by Curator
spineless (ss)	Color vision (eye; photoreceptor composition)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Anderson C; Reiss I; Zhou C ; et al. (2017) Natural variation in stochastic photoreceptor specification and color preference in Drosophila.	GP00001987	ss E1JIM6	Physiology	Single base insertion in the ss regulatory region upstream of the ss transcription start site. The insertion affects the stochastic on/off expression of the ss protein seen in the R7 photoreceptors: the presence of the insertion results in a significant decrease in the ratio of ss expressing to non-expressing R7 cells.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		spineless (ss)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
SPR	Coloration (ventral scales)	Cis-regulatory, Unknown	Podarcis muralis Common wall lizard - (species)	Intraspecific	Association Mapping	Andrade P; Pinho C; Pérez I de Lanuza G ; et al. (2019) Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall [...]	GP00002119	Spr Q64105	Morphology		Podarcis muralis Common wall lizard - (species)	Podarcis muralis Common wall lizard - (species)		SPR	Podarcis muralis Common wall lizard - (species)	Published - Accepted by Curator
SR-CII	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00001071	Sr-CII Q5ELW9	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		SR-CII	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
SRF3	Hybrid Incompatibility	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Alcázar R; García AV; Kronholm I ; et al. (2010) Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...] 1 Additional References Alcázar R; von Reth M; Bautor J (2014) Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]	GP00001072	SRF3 Q6R2K3	Physiology	Complex haplotype	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		SRF3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SRF3	Hybrid Incompatibility	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Alcázar R; García AV; Kronholm I ; et al. (2010) Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...] 1 Additional References Alcázar R; von Reth M; Bautor J (2014) Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]	GP00001073	SRF3 Q6R2K3	Physiology	Complex haplotype	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		SRF3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
srx-43	Pheromone response (ascaroside)	Cis-regulatory, Unknown	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Greene JS; Brown M; Dobosiewicz M ; et al. (2016) Balancing selection shapes density-dependent foraging behaviour. 1 Additional References Greene JS; Dobosiewicz M; Butcher RA (2016) Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foragin[...]	GP00001319	srx-43 O45767	Physiology	unknown	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		srx-43	Caenorhabditis elegans (species)	Published - Accepted by Curator
srx-44	Pheromone response (ascaroside)	Cis-regulatory, Unknown	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Greene JS; Dobosiewicz M; Butcher RA ; et al. (2016) Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foragin[...] 1 Additional References Greene JS; Brown M; Dobosiewicz M (2016) Balancing selection shapes density-dependent foraging behaviour.	GP00001504	srx-43 O45767	Physiology	Phenotypic change mapped to a small region located between 34bp and 72 bp upstream of the srx-44 start codon. This DNA region contains 9 changes between N2 strain and MY14 strain.	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		srx-44	Caenorhabditis elegans (species)	Published - Accepted by Curator
str-217	Xenobiotic resistance (insecticide; DEET)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Candidate Gene	Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018) A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.	GP00001783	str-217 Q9XX85	Physiology	deletion that leads to a predicted frame shift and early stop codon - the predicted resulting protein has only one transmembrane domain instead of the 7 transmembrane domains - 138-bp deletion in exon 2 and 3 and intervening intron according to https://www.wormbase.org/species/c_elegans/variation/WBVar02076179#02-45-3 and email from Emily Dennis from 9 March 2019 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		str-217	Caenorhabditis elegans (species)	Published - Accepted by Curator
str-217	Xenobiotic resistance (insecticide; DEET)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Candidate Gene	Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018) A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.	GP00001784	str-217 Q9XX85	Physiology	on chromosome V position 17000292 G>A stop_gained 13C>T - Gln5* N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		str-217	Caenorhabditis elegans (species)	Published - Accepted by Curator
sulfate transporter 1;1	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001429	SULTR1;1 Q9SAY1	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		sulfate transporter 1;1	Arabidopsis arenosa (species)	Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)	Xenobiotic resistance (oxamniquine)	Coding, Deletion	Schistosoma mansoni (species) D	Intraspecific	Linkage Mapping	Valentim CL; Cioli D; Chevalier FD ; et al. (2013) Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]	GP00001470	SULT-OR G4VLE5	Physiology	E142del	Schistosoma mansoni (species)	Schistosoma mansoni (species) D		Sulfotransferase-OXA-Resistance (SULT-OR)	Schistosoma mansoni (species)	Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)	Xenobiotic resistance (oxamniquine)	Coding, SNP	Schistosoma mansoni (species) D	Intraspecific	Linkage Mapping	Valentim CL; Cioli D; Chevalier FD ; et al. (2013) Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]	GP00001471	SULT-OR G4VLE5	Physiology	C35R (T>C)	Schistosoma mansoni (species)	Schistosoma mansoni (species) D		Sulfotransferase-OXA-Resistance (SULT-OR)	Schistosoma mansoni (species)	Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)	Xenobiotic resistance (oxamniquine)	Coding, SNP	Schistosoma mansoni (species)	Intraspecific	Candidate Gene	Valentim CL; Cioli D; Chevalier FD ; et al. (2013) Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]	GP00001472	SULT-OR G4VLE5	Physiology	F39 Sm > Y54 Sh (T>A) TTT>TAT	Schistosoma mansoni (species)	Schistosoma mansoni (species)		Sulfotransferase-OXA-Resistance (SULT-OR)	Schistosoma mansoni (species)	Published - Accepted by Curator
SVP (SHORT VEGETATIVE PHASE)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Méndez-Vigo B; Martínez-Zapater JM; Alonso-Blanco C (2013) The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic [...]	GP00001087	SVP Q9FVC1	Physiology	Ala32Val	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		SVP (SHORT VEGETATIVE PHASE)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
syntaxin1a	Eusociality	Cis-regulatory, Unknown	Lasioglossum albipes (species) D	Intraspecific	Association Mapping	Kocher SD; Mallarino R; Rubin BER ; et al. (2018) The genetic basis of a social polymorphism in halictid bees.	GP00002624	Syx1A Q24547	Behavior	Increased expression in eusocial individuals compared to solitary individuals	Lasioglossum albipes (species)	Lasioglossum albipes (species) D		syntaxin1a	Lasioglossum albipes (species)	Published - Accepted by Curator
T-box transcription factor (TBX3)	Coloration (coat)	Cis-regulatory, SNP	Equus caballus horse - (species) D	Intraspecific	Linkage Mapping	Imsland F; McGowan K; Rubin CJ ; et al. (2016) Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage colo[...]	GP00001461	TBX3 O15119	Morphology	G>T predicted to affect binding of the CCAT box-binding transcription factors NF-Y and NF-I ; Differs from the wild-type allele by a SNP downstream of the wild-type TBX3 sequence (located 1067bp downstream of the start of the larger nd2 deletion described in the nd2 entry) with allele nd1 = T compared with the wild-type D allele = G); an ancient variant	Equus caballus horse - (species)	Equus caballus horse - (species) D		T-box transcription factor (TBX3)	Equus caballus horse - (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Linkage Mapping	Coste A; Turner V; Ischer F ; et al. (2006) A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of hetero[...]	GP00001090	TAC1 A7IZW4	Physiology	N977D	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Gene Amplification, Complex Change	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001091	TAC1 A7IZW4	Physiology	Copy number Variant	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Coding, Deletion	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001092	TAC1 A7IZW4	Physiology	1a.a. deletion	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Coding, Deletion	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001093	TAC1 A7IZW4	Physiology	7a.a. deletion	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001094	TAC1 A7IZW4	Physiology	G980E	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001095	TAC1 A7IZW4	Physiology	A736V	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001096	TAC1 A7IZW4	Physiology	T225A	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
tan	Coloration (abdomen; female)	Cis-regulatory, Unknown	Drosophila erecta (species) D	Intraspecific	Linkage Mapping	Yassin A; Bastide H; Chung H ; et al. (2016) Ancient balancing selection at tan underlies female colour dimorphism in Drosophila erecta.	GP00001097	t Q9W369	Morphology	exact causing mutation(s) unknown - the t_MSE enhancer from the dark allele drives higher levels of GFP expression in D. melanogaster than from the light allele	Drosophila erecta (species)	Drosophila erecta (species) D		tan	Drosophila erecta (species)	Published - Accepted by Curator
tan	Coloration (abdomen)	Cis-regulatory, Unknown	Drosophila novamexicana (species) D	Intraspecific	Linkage Mapping	Wittkopp PJ; Stewart EE; Arnold LL ; et al. (2009) Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.	GP00001098	t Q9W369	Morphology	2.7kb non-coding interval; 13 SNPs + 2 indels differing between species	Drosophila americana (species)	Drosophila novamexicana (species) D		tan	Drosophila novamexicana (species)	Published - Accepted by Curator
tan	Coloration (thorax; abdomen; trident)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	Bastide H; Betancourt A; Nolte V ; et al. (2013) A genome-wide, fine-scale map of natural pigmentation variation in Drosophila melanogaster. 3 Additional References Dembeck LM; Huang W; Magwire MM (2015) Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Endler L; Betancourt AJ; Nolte V (2016) Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentat[...] Endler L; Gibert JM; Nolte V (2018) Pleiotropic effects of regulatory variation in tan result in correlation of two pigmentation traits [...]	GP00002622	t Q9W369	Morphology	exact causing mutation(s) unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		tan	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, Insertion N	Acinonyx jubatus cheetah - (species) D	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001105	Lvrn Q2KHK3	Morphology	1bp insertion resulting in frameshift p.N977Kfs110 N	Acinonyx jubatus cheetah - (species)	Acinonyx jubatus cheetah - (species) D		Taqpep	Acinonyx jubatus cheetah - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001106	Lvrn Q2KHK3	Morphology	D228N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species)	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001107	Lvrn Q2KHK3	Morphology	S59stop N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species)		Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species)	Intraspecific	Linkage Mapping	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001108	Lvrn Q2KHK3	Morphology	W841stop N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species)		Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
TAS1R3	Taste sensitivity (sugar)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Max M; Shanker YG; Huang L ; et al. (2001) Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. 1 Additional References Montmayeur JP; Liberles SD; Matsunami H (2001) A candidate taste receptor gene near a sweet taste locus.	GP00001110	TAS1R3 Q7RTX0	Physiology	I60T; is predicted to introduce a novel N-linked glycosylation site which might interfere with receptor dimerization	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		TAS1R3	Mus musculus house mouse - (species)	Published - Accepted by Curator
TAS2R38	Taste sensitivity (bitter)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kim UK; Jorgenson E; Coon H ; et al. (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthioc[...] 1 Additional References Wooding S; Bufe B; Grassi C (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees.	GP00001111	TAS2R38 P59533	Physiology	P49A and/or A262V and/or V296I	Homo sapiens human - (species)	Homo sapiens human - (species)		TAS2R38	Homo sapiens human - (species)	Published - Accepted by Curator
TAS2R38	Taste sensitivity (bitter)	Coding, SNP	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Wooding S; Bufe B; Grassi C ; et al. (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees.	GP00001112	TAS2R38 P59533	Physiology	M1R; eliminates start codon; protein initiates at later Met. Protein apparently null for signalling	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)		TAS2R38	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
TBX15	Ear shape	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Adhikari K; Reales G; Smith AJ ; et al. (2015) A genome-wide association study identifies multiple loci for variation in human ear morphology.	GP00001113	TBX15 Q96SF7	Morphology	Tbx15 enhancer variation including rs17023457 T or C alleles that affect CART1 binding on a conserved site	Homo sapiens human - (species)	Homo sapiens human - (species)		TBX15	Homo sapiens human - (species)	Published - Accepted by Curator
Tehao	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00001115	Tehao Q9VJX9	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Tehao	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
tetraspanin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Association Mapping	Jin L; Wang J; Guan F ; et al. (2018) Dominant point mutation in a tetraspanin gene associated with field-evolved resistance of cotton bol[...]	GP00002468	Tsp2A O46101	Physiology	L31S due to a nucleotide substitution T92C. CRISPR knockout of the tetraspanin gene restored susceptibility to a resistant strain whereas inserting the mutation conferred 125-fold resistance in a susceptible strain.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		tetraspanin	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
TFL1/FvTFL1	Flowering time Seasonal growth	Cis-regulatory, Unknown	Fragaria vesca wild strawberry - (species)	Intraspecific	Linkage Mapping	Koskela EA; Mouhu K; Albani MC ; et al. (2012) Mutation in TERMINAL FLOWER1 reverses the photoperiodic requirement for flowering in the wild strawb[...]	GP00001120	TFL1 P93003	Physiology Physiology	unknown	Fragaria vesca wild strawberry - (species)	Fragaria vesca wild strawberry - (species)		TFL1/FvTFL1	Fragaria vesca wild strawberry - (species)	Published - Accepted by Curator
thioester-containing protein 1	Pathogen resistance (Plasmodium; malaria parasite)	Coding, Unknown	Anopheles coluzzii (species)	Intraspecific	Linkage Mapping	Blandin SA; Wang-Sattler R; Lamacchia M ; et al. (2009) Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. 1 Additional References White BJ; Lawniczak MK; Cheng C (2011) Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodiu[...]	GP00001125	TEP-I Q9GYW4	Physiology	coding change - exact causing mutation(s) unknown	Anopheles gambiae African malaria mosquito - (species)	Anopheles coluzzii (species)		thioester-containing protein 1	Anopheles coluzzii (species)	Published - Accepted by Curator
thyroid-stimulating hormone-beta-2	Metabolic rate Thyroid Hormone (plasma concentration)	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Candidate Gene	Kitano J; Lema SC; Luckenbach JA ; et al. (2010) Adaptive divergence in the thyroid hormone signaling pathway in the stickleback radiation.	GP00001288	tshba B3DJU0	Physiology Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D		thyroid-stimulating hormone-beta-2	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
timeless (tim)	Diapause Locomotor activity	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Tauber E; Zordan M; Sandrelli F ; et al. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. 1 Additional References Sandrelli F; Tauber E; Pegoraro M (2007) A molecular basis for natural selection at the timeless locus in Drosophila melanogaster.	GP00001129	TIMELESS Q9UNS1	Physiology Behavior; Physiology	1bp insertion; allows production of longer protein from upstream start codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		timeless (tim)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
TLR6-TLR1-TLR10 cluster	Immune response	Unknown, Complex Change	Homo sapiens human - (species)	Intraspecific	Association Mapping	Laayouni H; Oosting M; Luisi P ; et al. (2014) Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-li[...] 1 Additional References Dannemann M; Andrés AM; Kelso J (2016) Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Huma[...]	GP00001130	TLR1 Q15399	Physiology	Several Complex Haplotypes under positive selection - evidence on Adaptive Introgression from Neanderthal (2 haplotypes) and Denisova (1 haplotype)	Homo sapiens human - (species)	Homo sapiens human - (species)		TLR6-TLR1-TLR10 cluster	Homo sapiens human - (species)	Published - Accepted by Curator
TMEM154	Pathogen resistance (lentivirus)	Coding, SNP	Ovis aries sheep - (species) D	Intraspecific	Association Mapping	Heaton MP; Clawson ML; Chitko-Mckown CG ; et al. (2012) Reduced lentivirus susceptibility in sheep with TMEM154 mutations.	GP00002242	TMEM154 Q6P9G4	Physiology	Mutation at conserved position associated to resistance in homozygous state	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		TMEM154	Ovis aries sheep - (species)	Published - Accepted by Curator
TMPRSS6	Hematopoiesis (mean blood corpuscular hemoglobin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001618	TMPRSS6 Q8IU80	Physiology	T>C at the associated SNP. Another SNP variant in strong LD p.V736A previously reported to influence iron homeostasis	Homo sapiens human - (species)	Homo sapiens human - (species)		TMPRSS6	Homo sapiens human - (species)	Published - Accepted by Curator
TPCN2	Coloration (coat)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2008) Two newly identified genetic determinants of pigmentation in Europeans.	GP00001131	TPCN2 Q8NHX9	Morphology	Met484Leu and/or Gly734Gln	Homo sapiens human - (species)	Homo sapiens human - (species)		TPCN2	Homo sapiens human - (species)	Published - Accepted by Curator
tra-3 calpain-like protease	Body size (temperature-size interaction)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Kammenga JE; Doroszuk A; Riksen JA ; et al. (2007) A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide pol[...]	GP00001133	tra-3 Q22036	Physiology	F96L	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		tra-3 calpain-like protease	Caenorhabditis elegans (species)	Published - Accepted by Curator
TRIB2	Body fat distribution (pericardial)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001559	TRIB2 Q92519	Physiology	A>G in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		TRIB2	Homo sapiens human - (species)	Published - Accepted by Curator
Trichohyalin	Hair type (straight)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Medland SE; Nyholt DR; Painter JN ; et al. (2009) Common variants in the trichohyalin gene are associated with straight hair in Europeans.	GP00001134	TCHH Q07283	Morphology	Not identified	Homo sapiens human - (species)	Homo sapiens human - (species)		Trichohyalin	Homo sapiens human - (species)	Published - Accepted by Curator
TRIM5alpha	Pathogen resistance (retroviruses)	Coding, SNP	Cercopithecidae Old World monkeys - (family)	Intraspecific	Candidate Gene	Newman RM; Hall L; Connole M ; et al. (2006) Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.	GP00001135	TRIM5 Q9C035	Physiology	several a.a. substitutions with retrovirus-specific activities; under balancing selection in several species	Cercopithecidae Old World monkeys - (family)	Cercopithecidae Old World monkeys - (family)		TRIM5alpha	Cercopithecidae Old World monkeys - (family)	Published - Accepted by Curator
TRIP11 (=GMAP-210)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00001138	TRIP11 Q15643	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		TRIP11 (=GMAP-210)	Homo sapiens human - (species)	Published - Accepted by Curator
TRPM1	Coloration (coat)	Cis-regulatory, Insertion	Equus caballus horse - (species) D	Intraspecific	Linkage Mapping	Bellone RR; Forsyth G; Leeb T ; et al. (2010) Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and [...] 3 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art. Bellone RR; Holl H; Setaluri V (2013) Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness a[...] Druml T; Grilz-Seger G; Neuditschko M (2017) Phenotypic and Genetic Analysis of the Leopard Complex Spotting in Noriker Horses.	GP00001140	TRPM1 Q7Z4N2	Morphology	a 1378 bp retroviral LTR insertion in intron 1 of TRPM1	Equus caballus horse - (species)	Equus caballus horse - (species) D		TRPM1	Equus caballus horse - (species)	Published - Accepted by Curator
tryptophan phenylalanine hydroxylase	Enzymatic activity	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Ruiz-Vázquez P; Silva FJ (1999) Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the in[...]	GP00002003	Hn P17276	Physiology	insertion of the transposable element B104/roo in the exon 3 of the Phenylalanine hydroxylase gene. Its presence alters the Phenylalanine hydroxylase splicing pattern; producing at least two aberrant mRNAs which contain part of the B104 sequence interrupting the coding region. This aberrant splicing is provoked by the use of a cryptic donor site encoded by the B104 3' long terminal repeat in combination with either the gene intron 3 acceptor site or a novel acceptor site generated by the target duplication caused by transposition. One of them; referred as mRNA type 1; encodes a truncated protein that could be predictably non-functional. In mRNA type 2; in spite of a 42 nt insertion; the Phenylalanine hydroxylase reading frame is not altered and it would encode for a protein with 14 extra amino acids which would be able to account for the low enzyme activity detected in this mutant.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		tryptophan phenylalanine hydroxylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, SNP	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Elleder D; Melder DC; Trejbalova K ; et al. (2004) Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]	GP00002256	tva Q6JBY7	Physiology	c.120C>G p.C40W	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Insertion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Elleder D; Melder DC; Trejbalova K ; et al. (2004) Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]	GP00002257	tva Q6JBY7	Physiology	c.48insCTCG N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Chen W; Liu Y; Li H ; et al. (2015) Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]	GP00002258	tva Q6JBY7	Physiology	c.502_511delCGCTCACCCC N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Chen W; Liu Y; Li H ; et al. (2015) Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]	GP00002259	tva Q6JBY7	Physiology	c.502_516delCGCTCACCCCGCCCC N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Reinišová M; Plachý J; Trejbalová K ; et al. (2012) Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]	GP00002260	tva Q6JBY7	Physiology	c.506-515del10 ; splicing N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Reinišová M; Plachý J; Trejbalová K ; et al. (2012) Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]	GP00002261	tva Q6JBY7	Physiology	c.507-511del5 ; splicing N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
two pore channel	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001433	TPC1 Q94KI8	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D		two pore channel	Arabidopsis arenosa (species)	Published - Accepted by Curator
Tyramine receptor 3	Exploration decision	Unknown, Unknown	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Bendesky A; Tsunozaki M; Rockman MV ; et al. (2011) Catecholamine receptor polymorphisms affect decision-making in C. elegans.	GP00001141	tyra-3 Q7JNP9	Behavior	Non-coding	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		Tyramine receptor 3	Caenorhabditis elegans (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (eyes; hair; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 2 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2008) Two newly identified genetic determinants of pigmentation in Europeans. Gudbjartsson DF; Sulem P; Stacey SN (2008) ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.	GP00001144	Tyr P11344	Morphology	R402Q	Homo sapiens human - (species)	Homo sapiens human - (species)		tyrosinase (TYR)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Panthera leo lion - (species) D	Intraspecific	Association Mapping	Cho YS; Hu L; Hou H ; et al. (2013) The tiger genome and comparative analysis with lion and snow leopard genomes.	GP00001346	Tyr P11344	Morphology	c.260G>A p.Arg87Gln	Panthera leo lion - (species)	Panthera leo lion - (species) D		tyrosinase (TYR)	Panthera leo lion - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin; coat)	Coding, SNP	Equus asinus ass - (species) D	Intraspecific	Candidate Gene	Utzeri VJ; Bertolini F; Ribani A ; et al. (2016) The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation [...]	GP00001347	Tyr P11344	Morphology	c.604C>G p.His202Asp	Equus asinus ass - (species)	Equus asinus ass - (species) D		tyrosinase (TYR)	Equus asinus ass - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin; eye; freckles)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Wilde S; Timpson A; Kirsanow K ; et al. (2014) Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the l[...]	GP00001348	Tyr P11344	Morphology	c. C>A p.Ser192Tyr	Homo sapiens human - (species)	Homo sapiens human - (species) D		tyrosinase (TYR)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin)	Coding, Deletion	Megaptera novaeangliae humpback whale - (species) D	Intraspecific	Candidate Gene	Polanowski AM; Robinson-Laverick SM; Paton D ; et al. (2012 Jan-Feb) Variation in the tyrosinase gene associated with a white humpback whale (Megaptera novaeangliae).	GP00002314	Tyr P11344	Morphology	(264 del C) at codon 88	Megaptera novaeangliae humpback whale - (species)	Megaptera novaeangliae humpback whale - (species) D		tyrosinase (TYR)	Megaptera novaeangliae humpback whale - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin)	Coding, SNP	Fejervarya kawamurai (species) D	Intraspecific	Candidate Gene	Miura I; Tagami M; Fujitani T ; et al. (2018) Spontaneous tyrosinase mutations identified in albinos of three wild frog species.	GP00002321	Tyr P11344	Morphology	c.169G>A p.Gly57Arg	Fejervarya kawamurai (species)	Fejervarya kawamurai (species) D		tyrosinase (TYR)	Fejervarya kawamurai (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat; albinism)	Coding, Deletion N	Nyctereutes procyonoides viverrinus (subspecies) D	Intraspecific	Candidate Gene	Mae Y; Nagara K; Miyazaki M ; et al. (2020) Complex intragene deletion leads to oculocutaneous albinism in tanuki (Japanese raccoon dog).	GP00002374	Tyr P11344	Morphology	"We examined the structure and nucleotide sequence of TYR in an albino tanuki and found that the third exon was removed due to a deletion of approximately 11 kb. In addition, two nonsynonymous nucleotide substitutions were found in the fifth exon. These mutations are possible causes of the albino phenotype; however, the order of occurrence is unclear. Even if the 11-kb deletion was not the first of these mutations, it is considered to cause a total loss of the tyrosinase function because the third exon carries codons for one of the two copper-binding sites of tyrosinase and these sites are essential for the enzyme function. Intriguingly, the deletion was not a simple removal of an 11-kb segment: an internal portion was retained as a segment in the reverse orientation. We propose possible formation processes for this mutation that involve multiple DNA scission events, or an inversion followed by a deletion." N	Nyctereutes procyonoides viverrinus (subspecies)	Nyctereutes procyonoides viverrinus (subspecies) D		tyrosinase (TYR)	Nyctereutes procyonoides viverrinus (subspecies)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Cervus elaphus red deer - (species) D	Intraspecific	Candidate Gene	Reiner G; Tramberend K; Nietfeld F ; et al. (2020) A genome-wide scan study identifies a single nucleotide substitution in the tyrosinase gene associat[...]	GP00002375	Tyr P11344	Morphology	"a non-synonymous mutation with exchange of a glycine residue at position 291 of the tyrosinase protein by arginine was identified as the cause of dilution of the coat colour" The mutation is on nucleotide 871 (G > A) but the exact codons are not specified in the paper.	Cervus elaphus red deer - (species)	Cervus elaphus red deer - (species) D		tyrosinase (TYR)	Cervus elaphus red deer - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Kenny EE; Timpson NJ; Sikora M ; et al. (2012) Melanesian blond hair is caused by an amino acid change in TYRP1.	GP00001155	Tyrp1 P07147	Morphology	R93C	Homo sapiens human - (species)	Homo sapiens human - (species) D		tyrosinase-related protein 1 (TYRP1)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (eyes; hair; skin)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Frudakis T; Thomas M; Gaskin Z ; et al. (2003) Sequences associated with human iris pigmentation. 1 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2008) Two newly identified genetic determinants of pigmentation in Europeans.	GP00001157	Tyrp1 P07147	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)		tyrosinase-related protein 1 (TYRP1)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, Insertion N	Falco cherrug Saker falcon - (species) D	Intraspecific	Candidate Gene	Cortimiglia C; Castiglioni B; Pizzi F ; et al. (2017) Involvement of tyrosinase-related protein 1 gene in the light brown plumage phenotype of Falco cherr[...]	GP00002285	Tyrp1 P07147	Morphology	c.79_80insT in exon 1 resulting in a frameshift change and a premature stop codon at position 81 of the deduced protein sequence ; which in the wild-type form contains 536 amino acids N	Falco cherrug Saker falcon - (species)	Falco cherrug Saker falcon - (species) D		tyrosinase-related protein 1 (TYRP1)	Falco cherrug Saker falcon - (species)	Published - Accepted by Curator
tyrosyl-tRNA synthetase (mt-TyrRS)	Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013) An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...] 1 Additional References Hoekstra LA; Siddiq MA; Montooth KL (2013) Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect o[...]	GP00001972	TyrRS-m Q9W107	Physiology	C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		tyrosyl-tRNA synthetase (mt-TyrRS)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
TZP	Plant growth (hypocotyl growth - light and temperature dependant)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Michael TP; Burger BT ; et al. (2008) A zinc knuckle protein that negatively controls morning-specific growth in Arabidopsis thaliana.	GP00001269	TZP Q9FIX7	Morphology	8bp insertion causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		TZP	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
UBE2E2	Body fat distribution (visceral/subcutaneous ratio)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001553	UBE2E2 Q96LR5	Physiology	T>C in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		UBE2E2	Homo sapiens human - (species)	Published - Accepted by Curator
Ubiquitin-specific peptidase 46 (Usp46)	Escape behavior (immobility in inescapable situations)	Coding, Deletion	Mus musculus house mouse - (species) D	Intraspecific	Linkage Mapping	Tomida S; Mamiya T; Sakamaki H ; et al. (2009) Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and for[...]	GP00001159	Usp46 P62069	Behavior	1a.a. deletion	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D		Ubiquitin-specific peptidase 46 (Usp46)	Mus musculus house mouse - (species)	Published - Accepted by Curator
UDP-glycosyltransferase 89A2	Plant secondary metabolites (xylosides vs. glucosides ratio)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Li X; Svedin E; Mo H ; et al. (2014) Exploiting natural variation of secondary metabolism identifies a gene controlling the glycosylation[...]	GP00001278	UGT89A2 Q9LZD8	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		UDP-glycosyltransferase 89A2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Ugt86Dd	Xenobiotic resistance (nicotine ; larval stage)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	Marriage TN; King EG; Long AD ; et al. (2014) Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cr[...] 1 Additional References Highfill CA; Tran JH; Nguyen SKT (2017) Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanoga[...]	GP00001406	Ugt86Dd Q9VGT8	Physiology	22-bp frameshift deletion in Ugt86Dd - CRISPR-induced deletions in Ugt86Dd lead to a large reduction in resistance N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Ugt86Dd	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Vanaso / disc losts	Olfactory behavior	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Fanara JJ; Robinson KO; Rollmann SM ; et al. (2002) Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.	GP00001164	dlt Q8T626	Behavior	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Vanaso / disc losts	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
VGLL3 (vestigial-like family member 3 gene )	Age of sexual maturity	Unknown, Unknown	Salmo salar Atlantic salmon - (species)	Intraspecific	Association Mapping	Barson NJ; Aykanat T; Hindar K ; et al. (2015) Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon. 1 Additional References Ayllon F; Kjærner-Semb E; Furmanek T (2015) The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon (Salmo salar L.) M[...]	GP00001167	VGLL3 A8MV65	Physiology	candidate amino-acid substitutions	Salmo salar Atlantic salmon - (species)	Salmo salar Atlantic salmon - (species)		VGLL3 (vestigial-like family member 3 gene )	Salmo salar Atlantic salmon - (species)	Published - Accepted by Curator
VIN3	Flowering time	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ågren J; Oakley CG; Lundemo S ; et al. (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00001538	VIN3 Q9FIE3	Physiology	4 nonsynonymous substitutions and a 3 bp deletion	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		VIN3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Linkage Mapping	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001168	VKORC1 Q9BQB6	Physiology	R98W	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001169	VKORC1 Q9BQB6	Physiology	V29L	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001170	VKORC1 Q9BQB6	Physiology	V45A	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001171	VKORC1 Q9BQB6	Physiology	R58G	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001172	VKORC1 Q9BQB6	Physiology	L128S	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Vkorc1	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001173	VKORC1 Q9BQB6	Physiology	Y139C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Vkorc1	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus spretus western wild mouse - (species)	Intraspecific	Candidate Gene	Song Y; Endepols S; Klemann N ; et al. (2011) Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world [...]	GP00001174	VKORC1 Q9BQB6	Physiology	Several candidate coding changes	Mus musculus house mouse - (species)	Mus spretus western wild mouse - (species)		Vkorc1	Mus spretus western wild mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Linkage Mapping	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.	GP00001175	VKORC1 Q9BQB6	Physiology	Y139C	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001176	VKORC1 Q9BQB6	Physiology	S56P	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001177	VKORC1 Q9BQB6	Physiology	L128S	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001178	VKORC1 Q9BQB6	Physiology	L128Q	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001179	VKORC1 Q9BQB6	Physiology	L120Q	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001180	VKORC1 Q9BQB6	Physiology	Y139S	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Lasseur R; Longin-Sauvageon C; Videmann B ; et al. (2005) Warfarin resistance in a French strain of rats. 1 Additional References Pelz HJ; Rost S; Hünerberg M (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001181	VKORC1 Q9BQB6	Physiology	Y139F	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Tanaka KD; Kawai YK; Ikenaka Y ; et al. (2013) A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.	GP00001182	VKORC1 Q9BQB6	Physiology	R33P	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
VRN1	Flowering time	Cis-regulatory, Indel	Lolium perenne (species)	Intraspecific	Candidate Gene	Asp T; Byrne S; Gundlach H ; et al. (2011) Comparative sequence analysis of VRN1 alleles of Lolium perenne with the co-linear regions in barley[...]	GP00001183	VRN1 Q8L3W1	Physiology	8.6kb indel in first intron	Lolium perenne (species)	Lolium perenne (species)		VRN1	Lolium perenne (species)	Published - Accepted by Curator
WDR66	Hematopoiesis (mean blood platelet volume)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001604	WDR66 Q8TBY9	Physiology	A>G at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)		WDR66	Homo sapiens human - (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius erato crimson-patched longwing - (species)	Intraspecific	Association Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001205	WntA A0A077DF90	Morphology	unknown	Heliconius erato crimson-patched longwing - (species)	Heliconius erato crimson-patched longwing - (species)		WntA	Heliconius erato crimson-patched longwing - (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius hecale (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001206	WntA A0A077DF90	Morphology	unknown	Heliconius hecale (species)	Heliconius hecale (species)		WntA	Heliconius hecale (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius ismenius (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001207	WntA A0A077DF90	Morphology	unknown	Heliconius ismenius (species)	Heliconius ismenius (species)		WntA	Heliconius ismenius (species)	Published - Accepted by Curator
WntA	Coloration (wing; Batesian mimicry)	Cis-regulatory, Unknown	Limenitis arthemis white admiral - (species)	Intraspecific	Linkage Mapping	Gallant JR; Imhoff VE; Martin A ; et al. (2014) Ancient homology underlies adaptive mimetic diversity across butterflies.	GP00001208	WntA A0A077DF90	Morphology	Complex Haplotype in first intron perfectly associated with phenotype: 173 fixed single-nucleotide polymorphisms (SNPs) in complete linkage disequilibrium (LD) located 23	Limenitis arthemis white admiral - (species)	Limenitis arthemis white admiral - (species)		WntA	Limenitis arthemis white admiral - (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Indel	Heliconius cydno (species)	Intraspecific	Linkage Mapping	Gallant JR; Imhoff VE; Martin A ; et al. (2014) Ancient homology underlies adaptive mimetic diversity across butterflies. 1 Additional References Martin A; Papa R; Nadeau NJ (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001209	WntA A0A077DF90	Morphology	1.8-kb indel that was perfectly associated with variation in forewing melanin patterning	Heliconius cydno (species)	Heliconius cydno (species)		WntA	Heliconius cydno (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius pachinus (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand. 1 Additional References Gallant JR; Imhoff VE; Martin A (2014) Ancient homology underlies adaptive mimetic diversity across butterflies.	GP00001210	WntA A0A077DF90	Morphology	Complex cis-regulatory haplotype : 170 fixed differences were detected among comparisons of allopatric H. c. galanthus and H. pachinus	Heliconius cydno (species)	Heliconius pachinus (species)		WntA	Heliconius pachinus (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius erato crimson-patched longwing - (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001211	WntA A0A077DF90	Morphology	Not identified	Heliconius himera (species)	Heliconius erato crimson-patched longwing - (species)		WntA	Heliconius erato crimson-patched longwing - (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius erato crimson-patched longwing - (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001212	WntA A0A077DF90	Morphology	Not identified	Heliconius himera (species)	Heliconius erato crimson-patched longwing - (species)		WntA	Heliconius erato crimson-patched longwing - (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius erato crimson-patched longwing - (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001213	WntA A0A077DF90	Morphology	Not identified	Heliconius himera (species)	Heliconius erato crimson-patched longwing - (species)		WntA	Heliconius erato crimson-patched longwing - (species)	Published - Accepted by Curator
WntA	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius melpomene postman butterfly - (species)	Intraspecific	Linkage Mapping	Martin A; Papa R; Nadeau NJ ; et al. (2012) Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.	GP00001214	WntA A0A077DF90	Morphology	unknown ; non-coding with effect on spatial gene expression	Heliconius melpomene postman butterfly - (species)	Heliconius melpomene postman butterfly - (species)		WntA	Heliconius melpomene postman butterfly - (species)	Published - Accepted by Curator
WRR4	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Borhan MH; Gunn N; Cooper A ; et al. (2008) WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis t[...]	GP00001215	ADR2 Q9C7X0	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		WRR4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Xa1	Pathogen resistance	Unknown, Unknown	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Yoshimura S; Yamanouchi U; Katayose Y ; et al. (1998) Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation.	GP00001216	XA1 A0A0H5AGW3	Physiology	unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Xa1	Oryza sativa rice - (species)	Published - Accepted by Curator
Xa21	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Song WY; Wang GL; Chen LL ; et al. (1995) A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21.	GP00001217	Xa21 A0PIA3	Physiology	unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Xa21	Oryza sativa rice - (species)	Published - Accepted by Curator
Xa26	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Sun X; Cao Y; Yang Z ; et al. (2004) Xa26, a gene conferring resistance to Xanthomonas oryzae pv. oryzae in rice, encodes an LRR receptor[...]	GP00001218	Xa26 Q00KZ8	Physiology	unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Xa26	Oryza sativa rice - (species)	Published - Accepted by Curator
yellow	Coloration (body; wing)	Cis-regulatory, Inversion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Zakharenko LP; p6acheva EM; Romanova OA ; et al. (2000) hobo-induced rearrangements are responsible for mutation bursts at the yellow locus in a natural pop[...]	GP00001961	y P09957	Morphology	y[2-717] - Inversion that occurred between two hobo elements: one located 129 bp from the start site of yellow transcription and the other in the distal telomere region. The yellow phenotype is caused by the separation of the body and wing enhancers from the transcription unit.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		yellow	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
yellow	Coloration (wing)	Cis-regulatory, Unknown	Danaus chrysippus African queen - (species)	Intraspecific	Association Mapping	Martin SH; Singh KS; Gordon IJ ; et al. (2020) Whole-chromosome hitchhiking driven by a male-killing endosymbiont.	GP00002430	y P09957	Morphology	A cluster of SNPs most strongly associated with background colour (B locus) is found just upstream of the gene yellow and a phylogenetic network for a 30-kb region around yellow groups individuals nearly perfectly by phenotype; although some individuals classed as heterozygous were intermingled with homozygotes.	Danaus chrysippus African queen - (species)	Danaus chrysippus African queen - (species)		yellow	Danaus chrysippus African queen - (species)	Published - Accepted by Curator
yellow	Coloration (body; wing)	Coding, Insertion N	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Heinze SD; Kohlbrenner T; Ippolito D ; et al. (2017) CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body loc[...]	GP00002623	y P09957	Morphology	a 4 bp insertion at amino acid position 67 that causes a frameshift and a premature stop codon N	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		yellow	Musca domestica house fly - (species)	Published - Accepted by Curator
zic1/zic4	Fin morphology (skeleton; dorsal fin; caudal fin) Pigmentation (ventralized trunk)	Cis-regulatory, Insertion	Oryzias latipes Japanese medaka - (species) D	Intraspecific	Linkage Mapping	Moriyama Y; Kawanishi T; Nakamura R ; et al. (2012) The medaka zic1/zic4 mutant provides molecular insights into teleost caudal fin evolution. 1 Additional References Inoue Y; Saga T; Aikawa T (2017) Complete fusion of a transposon and herpesvirus created the Teratorn mobile element in medaka fish.	GP00002038	Zic1 P46684	Morphology Morphology	The mutant phenotype is caused by a dramatic decrease of zic1/zic4 expression in the dorsal somites. The insertion of a transposon (“Albatross”) into an enhancer region (downstream of zic4) of the transcription factors zic1 and zic4 causes this phenotype. Both genes are expressed by a bi-directional promoter. The transposon insertion is proposed to interfere with the transcriptional regulation of zic1/zic4; resulting in the disturbance of the expression of the transcription factors in the dorsal somites (the expression of zic1/zic4 in other parts of the body is not affected in this mutant) and ultimately causing a ventralized trunk phenotype. In Inoue et al. (2017) it was shown that the transposon “Albatross” is actually larger than originally predicted; and is now called “Teratorn”. Teratorn is around 180kb long and appears to originate from the fusion of a DNA transposon and a herpesvirus.	Oryzias latipes Japanese medaka - (species)	Oryzias latipes Japanese medaka - (species) D		zic1/zic4	Oryzias latipes Japanese medaka - (species)	Published - Accepted by Curator
Zmr1	Xenobiotic resistance (fungicide) Melanin content	2 Mutations: Cis-regulatory	Zymoseptoria tritici (species)	Intraspecific	Linkage Mapping	Krishnan P; Meile L; Plissonneau C ; et al. (2018) Transposable element insertions shape gene regulation and melanin production in a fungal pathogen of[...]	GP00001715	CMR1 Q06F33	Physiology Physiology	2 mutations	Zymoseptoria tritici (species)	Zymoseptoria tritici (species)		Zmr1	Zymoseptoria tritici (species)	Published - Accepted by Curator
ZmVPP1	Drought tolerance	Cis-regulatory, Insertion	Zea mays (species)	Intraspecific	Association Mapping	Wang X; Wang H; Liu S ; et al. (2016) Genetic variation in ZmVPP1 contributes to drought tolerance in maize seedlings.	GP00001567	GRMZM2G170927 A0A172DSU8	Physiology	A 366-bp insertion in the promoter containing 3 MYB cis elements confers drought-inducible expression of ZmVPP1 in drought-tolerant genotypes	Zea mays (species)	Zea mays (species)		ZmVPP1	Zea mays (species)	Published - Accepted by Curator
β-adrenergic octopamine receptor gene (AOR)	Xenobiotic resistance (amitraz)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Association Mapping	Corley SW; Jonsson NN; Piper EK ; et al. (2013) Mutation in the RmβAOR gene is associated with amitraz resistance in the cattle tick Rhipicephalus m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002396	Oct-TyrR P22270	Physiology	L64I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		β-adrenergic octopamine receptor gene (AOR)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator