Gephebase

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Your research retrieved 877 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
18-wheeler	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00000001	18w A1ZBR2	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	18-wheeler	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Indel N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000002	ABCA2 A0A0S0G7V0	Physiology	65bp indel in exon16 inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000003	ABCA2 A0A0S0G7V0	Physiology	5bp deletion inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000004	ABCA2 A0A0S0G7V0	Physiology	5bp (GAATA) nucleotide duplication inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCC11	Apocrine secretion (ear wax type ; axillary odor)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Yoshiura K; Kinoshita A; Ishida T ; et al. (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. 1 Additional References Martin A; Saathoff M; Kuhn F (2010) A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.	GP00000010	ABCC11 Q96J66	Physiology	1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette	Homo sapiens human - (species)	Homo sapiens human - (species)	ABCC11	Homo sapiens human - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Unknown, Unknown	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000014	ABCC2 A0A0E3ZDK3	Physiology	Not identified	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCC2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000017	ABO P16442	Physiology	Gly268 (group A) <-> Ala (group B)	Homininae (subfamily)	Homininae (subfamily)	ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000018	ABO P16442	Physiology	Leu266 (group A) <-> Met (group B)	Homininae (subfamily)	Homininae (subfamily)	ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Calafell F; Roubinet F; Ramírez-Soriano A (2008) Evolutionary dynamics of the human ABO gene.	GP00000019	ABO P16442	Physiology	1bp deletion (258G) resulting in frameshift N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993) Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000020	ABO P16442	Physiology	Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function) two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.	Homo sapiens human - (species)	Homo sapiens human - (species)	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000021	ABO P16442	Physiology	1bp insertion resulting in premature stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000022	ABO P16442	Physiology	1bp change resulting in stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species)	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000023	ABO P16442	Physiology	Uncertain; possibly 9bp deletion resultin in 3a.a. deletion	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)	ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Unknown, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000024	ABO P16442	Physiology	unknown	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)	ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ACD6 = ACCELERATED CELL DEATH 6	Plant size Pathogen resistance (plant microbes) Herbivore resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Todesco M; Balasubramanian S; Hu TT ; et al. (2010) Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana. 1 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.	GP00000025	ACD6 Q8LPS2	Physiology Physiology Physiology	Various	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	ACD6 = ACCELERATED CELL DEATH 6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D	Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	G119S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	G119S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000030	Ace P07140	Physiology	331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D	Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Fournier D; Bride JM; Hoffmann F ; et al. (1992) Acetylcholinesterase. Two types of modifications confer resistance to insecticide. 1 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000032	Ace P07140	Physiology	Phe368 -> Tyr	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000033	Ace P07140	Physiology	Ile/Val199 -> Thr	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000034	Ace P07140	Physiology	Gly303 -> Ala	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00000035	Ace P07140	Physiology	Phe115 -> Ser	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)	Acetylcholinesterase (Ace)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, Deletion	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008) A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...] 1 Additional References Kakani EG; Bon S; Massoulié J (2011) Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides.	GP00000038	Ace P07140	Physiology	9bp deletion of three glutamine residues at positions 642_644	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (abdomen; female-limited)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Morgan AH ; et al. (2000) Both naturally occurring insertions of transposable elements and intermediate frequency polymorphism[...]	GP00000046	sc P10084	Morphology	transposon insertion in non-coding region	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	achaete-scute complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (abdomen)	Cis-regulatory, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Morgan AH ; et al. (2000) Both naturally occurring insertions of transposable elements and intermediate frequency polymorphism[...]	GP00000047	sc P10084	Morphology	indel MC21 in promoter region of scute	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	achaete-scute complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
achaete-scute complex	Bristle number (thorax)	Cis-regulatory, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Gruber JD; Genissel A; Macdonald SJ ; et al. (2007) How repeatable are associations between polymorphisms in achaete-scute and bristle number variation [...]	GP00000048	sc P10084	Morphology	indel MC22 in promoter region of scute	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	achaete-scute complex	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ADAMTS10	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000050	ADAMTS10 Q9H324	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	ADAMTS10	Homo sapiens human - (species)	Published - Accepted by Curator
AGAMOUS-Like6	Plant architecture Inflorescence architecture	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Huang X; Effgen S; Meyer RC ; et al. (2012) Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in[...]	GP00000053	AGL6 P29386	Morphology Morphology	Pro201Leu	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AGAMOUS-Like6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	5 Mutations:	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Association Mapping	Linnen CR; Poh YP; Peterson BK ; et al. (2013) Adaptive evolution of multiple traits through multiple mutations at a single gene.	GP00000054	Asip Q03288	Morphology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)	Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Gene Loss, Deletion N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000055	Asip Q03288	Morphology	125kb deletion including 5' CDS of Agouti N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)	Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Coding, SNP N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000056	Asip Q03288	Morphology	Premature stop codon at residue 65 N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)	Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Cis-regulatory, Unknown	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Linkage Mapping	Manceau M; Domingues VS; Mallarino R ; et al. (2011) The developmental role of Agouti in color pattern evolution.	GP00000057	Asip Q03288	Morphology	Not identified	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)	Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Intraspecific	Linkage Mapping	Rieder S; Taourit S; Mariat D ; et al. (2001) Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their associati[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000062	Asip Q03288	Morphology	11bp deletion in exon 2 N	Equus caballus horse - (species)	Equus caballus horse - (species) D	Agouti	Equus caballus horse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Panthera pardus leopard - (species) D	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000065	Asip Q03288	Morphology	nonsense mutation located in exon 4 (C333A) predicted to introduce a stop codon at amino acid position 111 N	Panthera pardus leopard - (species)	Panthera pardus leopard - (species) D	Agouti	Panthera pardus leopard - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP	Catopuma temminckii Asiatic golden cat - (species)	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000066	Asip Q03288	Morphology	C128W	Catopuma temminckii Asiatic golden cat - (species)	Catopuma temminckii Asiatic golden cat - (species)	Agouti	Catopuma temminckii Asiatic golden cat - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (skin; hair)	Cis-regulatory, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Bonilla C; Boxill LA; Donald SA ; et al. (2005) The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with dar[...] 2 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2008) Two newly identified genetic determinants of pigmentation in Europeans. Voisey J; Gomez-Cabrera Mdel C; Smit DJ (2006) A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA.	GP00000070	Asip Q03288	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	Agouti (ASIP)	Homo sapiens human - (species)	Published - Accepted by Curator
agrecan	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000072	ACAN P16112	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	agrecan	Homo sapiens human - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Choudhary M; Laurie CC (1991) Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...] 3 Additional References Laurie CC; Bridgham JT; Choudhary M (1991) Associations between DNA sequence variation and variation in expression of the Adh gene in natural p[...] King EG; Merkes CM; McNeil CL (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource. Siddiq MA; Loehlin DW; Montooth KL (2017) Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaste[...]	GP00000074	Adh P00334	Physiology	Thr192Lys. Historical note : this discovery is actually based on progressive mapping started before 1980; and on early population genetics work by Kreitman 1983 (PMID: 6410283).	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Cis-regulatory, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Laurie CC; Stam LF (1994) The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaste[...] 1 Additional References King EG; Merkes CM; McNeil CL (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource.	GP00000075	Adh P00334	Physiology	Indel in intron. Slow alleles nearly always have the 29 bp version of delta1 and Fast alleles predominantly have the 34bp version	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Stam LF; Laurie CC (1996) Molecular dissection of a major gene effect on a quantitative trait: the level of alcohol dehydrogen[...]	GP00000076	Adh P00334	Physiology	cis-acting variant at Adh other than F/S and intron indel 1	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)	Xenobiotic resistance (alcohol)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Li H; Mukherjee N; Soundararajan U ; et al. (2007) Geographically separate increases in the frequency of the derived ADH1B47His allele in eastern and [...] 1 Additional References Li H; Mukherjee N; Soundararajan U (2007)* Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]	GP00000077	ADH1B P00325	Physiology	Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication	Homo sapiens human - (species)	Homo sapiens human - (species)	alcohol dehydrogenase (ADH1B)	Homo sapiens human - (species)	Published - Accepted by Curator
AMPD1 (=CG32626)	Drug resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kislukhin G; King EG; Walters KN ; et al. (2013) The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.	GP00000083	AMPD1 P23109	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	AMPD1 (=CG32626)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]	Drug resistance	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Wessels JA; van der Kooij SM; le Cessie S ; et al. (2007) A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset[...]	GP00000084	AMPD1 P23109	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]	Homo sapiens human - (species)	Published - Accepted by Curator
amylase 1 (AMY1)	Starch processing	Gene Amplification, Complex Change	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Perry GH; Dominy NJ; Claw KG ; et al. (2007) Diet and the evolution of human amylase gene copy number variation. 1 Additional References Falchi M; El-Sayed Moustafa JS; Takousis P (2014) Low copy number of the salivary amylase gene predisposes to obesity.	GP00000085	AMY1A P04745	Physiology	Probably gene duplication	Homo sapiens human - (species)	Homo sapiens human - (species)	amylase 1 (AMY1)	Homo sapiens human - (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000089	AN2 A4GRU8	Morphology	1bp deletion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000090	AN2 A4GRU8	Morphology	4bp insertion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000091	AN2 A4GRU8	Morphology	W196* N	Petunia integrifolia (species)	Petunia axillaris (species)	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000092	AN2 A4GRU8	Morphology	1bp deletion; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000093	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000094	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)	anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
AOP2	Glucosinolate content	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000095	AOP2 Q945B5	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AOP2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AOP3	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000096	AOP3 Q9ZTA1	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AOP3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
APL1 cluster	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Riehle MM; Markianos K; Niaré O ; et al. (2006) Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. 1 Additional References Rottschaefer SM; Riehle MM; Coulibaly B (2011) Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 mal[...]	GP00000098	APL1A L7RQU1	Physiology	Not identified	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	APL1 cluster	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
APOE (apolipoprotein E)	Aging	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000099	APOE P02649	Physiology	Cys112Arg	Homo sapiens human - (species)	Homo sapiens human - (species)	APOE (apolipoprotein E)	Homo sapiens human - (species)	Published - Accepted by Curator
APSR	Sulfate content (shoot)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007) Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.	GP00000100	APR2 P92981	Physiology	A399E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	APSR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ARHGAP15	Pathogen resistance (Trypanosoma)	Coding, SNP	Bos taurus cattle - (species)	Intraspecific	Linkage Mapping	Noyes H; Brass A; Obara I ; et al. (2011) Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]	GP00000103	Arhgap15 Q811M1	Physiology	H282P	Bos oxen, cattle - (genus)	Bos taurus cattle - (species)	ARHGAP15	Bos taurus cattle - (species)	Published - Accepted by Curator
AT5G41740/AT5G41750	Hybrid incompatibility (auto-immune necrosis)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Bomblies K; Lempe J; Epple P ; et al. (2007) Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants.	GP00000105	MUF8.2 F4JYI4	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AT5G41740/AT5G41750	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtHKT1	Salt tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Rus A; Baxter I; Muthukumar B ; et al. (2006) Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. 1 Additional References Baxter I; Brazelton JN; Yu D (2010) A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the[...]	GP00000124	HKT1 Q84TI7	Physiology	725bp deletion of part of upstream repeat region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtHKT1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtHKT1	Salt tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Rus A; Baxter I; Muthukumar B ; et al. (2006) Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. 1 Additional References Baxter I; Brazelton JN; Yu D (2010) A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the[...]	GP00000125	HKT1 Q84TI7	Physiology	687bp deletion of part of upstream repeat region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtHKT1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ATP2B4	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Timmann C; Thye T; Vens M ; et al. (2012) Genome-wide association study indicates two novel resistance loci for severe malaria.	GP00000127	ATP2B4 P23634	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	ATP2B4	Homo sapiens human - (species)	Published - Accepted by Curator
ATR13	Pathogenicity	Coding, SNP	Hyaloperonospora parasitica (species)	Intraspecific	Linkage Mapping	Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004) Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. 1 Additional References Allen RL; Meitz JC; Baumber RE (2008) Natural variation reveals key amino acids in a downy mildew effector that alters recognition specifi[...]	GP00000128	Atr13 Q5G7K8	Physiology	Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown	Hyaloperonospora parasitica (species)	Hyaloperonospora parasitica (species)	ATR13	Hyaloperonospora parasitica (species)	Published - Accepted by Curator
avpr1a	Male sexual fidelity (monogamous regime)	Cis-regulatory, Unknown	Microtus ochrogaster prairie vole - (species)	Intraspecific	Candidate Gene	Okhovat M; Berrio A; Wallace G ; et al. (2015) Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain.	GP00000129	Avpr1a Q62463	Behavior	unknown	Microtus ochrogaster prairie vole - (species)	Microtus ochrogaster prairie vole - (species)	avpr1a	Microtus ochrogaster prairie vole - (species)	Published - Accepted by Curator
bab1	Coloration (abdomen)	3 Mutations: Cis-regulatory Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kopp A; Graze RM; Xu S ; et al. (2003) Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanog[...] 1 Additional References Bickel RD; Kopp A; Nuzhdin SV (2011) Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL.	GP00000130	bab1 Q9W0K7	Morphology	3 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	bab1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
bab2	Fertility (ovariole number)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Green DA; Extavour CG (2012) Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...] 1 Additional References Bergland AO; Genissel A; Nuzhdin SV (2008) Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole [...]	GP00000132	bab2 Q9W0K4	Physiology	unknown ; loss of function reduces ovariole number	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	bab2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
BCMA	Glucosinolate content Herbivore resistance	3 Mutations:	Boechera stricta (species)	Intraspecific	Linkage Mapping	Prasad KV; Song BH; Olson-Manning C ; et al. (2012) A gain-of-function polymorphism controlling complex traits and fitness in nature.	GP00000136	J9QWI9	Physiology Physiology	3 mutations	Boechera stricta (species)	Boechera stricta (species)	BCMA	Boechera stricta (species)	Published - Accepted by Curator
beta-defensin 103 (CBD103) [pseudo-replicate of Dog entry; introgression of Dog allele]	Coloration (coat)	Coding, Deletion	Canis latrans coyote - (species) D	Intraspecific	Linkage Mapping	Anderson TM; vonHoldt BM; Candille SI ; et al. (2009) Molecular and evolutionary history of melanism in North American gray wolves. 1 Additional References Anderson TM; vonHoldt BM; Candille SI (2009) Molecular and evolutionary history of melanism in North American gray wolves.	GP00000142	CBD103 Q30KV0	Morphology	3bp in-frame deletion in exon 2 = deletion of Gly23	Canis lupus gray wolf - (species)	Canis latrans coyote - (species) D	beta-defensin 103 (CBD103) [pseudo-replicate of Dog entry; introgression of Dog allele]	Canis latrans coyote - (species)	Published - Accepted by Curator
BHLHE41	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Huerta-Sánchez E; Degiorgio M; Pagani L ; et al. (2013) Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.	GP00000144	BHLHE41 Q9C0J9	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	BHLHE41	Homo sapiens human - (species)	Published - Accepted by Curator
BMP6	Tooth number	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Cleves PA; Ellis NA; Jimenez MT ; et al. (2014) Evolved tooth gain in sticklebacks is associated with a cis-regulatory allele of Bmp6. 2 Additional References Ellis NA; Glazer AM; Donde NN (2015) Distinct developmental genetic mechanisms underlie convergently evolved tooth gain in sticklebacks. Erickson PA; Cleves PA; Ellis NA (2015) A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression[...]	GP00000154	Bmp6 P20722	Morphology	Candidate enhancer of 190bp recapitulating tooth and fin expression of BMP6	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	BMP6	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
Brevis radix (BRX)	Root size (shorter)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Mouchel CF; Briggs GC; Hardtke CS (2004) Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell prolifer[...]	GP00000157	BRX Q17TI5	Morphology	premature stop codon in exon 4; TGG>TGA; truncated protein missing approximately two-thirds of the C terminus N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Unknown N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]	GP00000160	BtR Q19KJ3	Physiology	premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	BTR1- Cadherin-like protein	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	BTR1- Cadherin-like protein	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, Deletion	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000164	BtR Q19KJ3	Physiology	24bp in-frame deletion	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
BTR1- Cadherin-like protein	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	BTR1- Cadherin-like protein	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
catechol-O-methyltransferase (COMT)	Pain sensitivity	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Nackley AG; Shabalina SA; Tchivileva IE ; et al. (2006) Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary[...]	GP00000171	COMT P21964	Behavior	G/C - The synonymous mutation(s) affect mRNA stability and loop structures	Homo sapiens human - (species)	Homo sapiens human - (species)	catechol-O-methyltransferase (COMT)	Homo sapiens human - (species)	Published - Accepted by Curator
Catecholamines up	Bristle number Lifespan Locomotor activity Sleep	Coding, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Carbone MA; Jordan KW; Lyman RF ; et al. (2006) Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Droso[...] 1 Additional References Stein MB; Koverola C; Hanna C (1997) Hippocampal volume in women victimized by childhood sexual abuse.	GP00000172	Catsup Q9V3A4	Morphology Physiology Behavior Behavior	unknown; but most large-effect variants appear to be coding	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Catecholamines up	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CBF gene cluster	Temperature tolerance (cold)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Gery C; Zuther E; Schulz E ; et al. (2011) Natural variation in the freezing tolerance of Arabidopsis thaliana: effects of RNAi-induced CBF dep[...]	GP00000174	B1NSN2	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CBF gene cluster	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CCL3L1	Pathogen resistance (HIV)	Gene Amplification, Indel	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Gonzalez E; Kulkarni H; Bolivar H ; et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.	GP00000177	CCL3L1 P16619	Physiology	Copy number Variant	Homo sapiens human - (species)	Homo sapiens human - (species)	CCL3L1	Homo sapiens human - (species)	Published - Accepted by Curator
CHKov1	Pathogen resistance Xenobiotic resistance (insecticide)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Magwire MM; Bayer F; Webster CL ; et al. (2011) Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...] 1 Additional References Aminetzach YT; Macpherson JM; Petrov DA (2005) Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila.	GP00000182	CHKov1 Q961V7	Physiology Physiology	Insertion of a Doc TE element resulting in novel; seemingly functional short protein	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CHKov1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CHRNA3/5 nicotine receptor cluster	Aging Smoking behavior	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000185	CHRNA3 P32297	Physiology Physiology	unknown; complex variation with SNP association signal	Homo sapiens human - (species)	Homo sapiens human - (species)	CHRNA3/5 nicotine receptor cluster	Homo sapiens human - (species)	Published - Accepted by Curator
Couch potato	Diapause	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Schmidt PS; Zhu CT; Das J ; et al. (2008) An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]	GP00000191	cpo Q01617	Physiology	Ile462Lys	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Couch potato	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele	Flowering time Fruit shape (fruit length) Flower morphology (ovule number per fruit) Fertility (percentage of unfertilized ovules)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001) A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2. 3 Additional References Olsen KM; Halldorsdottir SS; Stinchcombe JR (2004) Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. el-Assal SE; Alonso-Blanco C; Hanhart CJ (2004) Pleiotropic effects of the Arabidopsis cryptochrome 2 allelic variation underlie fruit trait-related[...] Botto JF; Alonso-Blanco C; Garzarón I (2003) The Cape Verde Islands allele of cryptochrome 2 enhances cotyledon unfolding in the absence of blue [...]	GP00000192	CRY2 Q96524	Physiology Morphology Morphology Physiology	V367M	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Cryptochrome 2 (CRY2) EDI allele	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CYC-like HaCYC2c	Flower morphology	Cis-regulatory, Insertion	Helianthus annuus common sunflower - (species) D	Intraspecific	Linkage Mapping	Chapman MA; Tang S; Draeger D ; et al. (2012) Genetic analysis of floral symmetry in Van Gogh's sunflowers reveals independent recruitment of CYCL[...]	GP00000193	CYC O49250	Morphology	999bp insertion in promoter	Helianthus annuus common sunflower - (species)	Helianthus annuus common sunflower - (species) D	CYC-like HaCYC2c	Helianthus annuus common sunflower - (species)	Published - Accepted by Curator
CYC-like RAY1/RAY2	Flower morphology	Gene Amplification, Complex Change	Senecio vulgaris (species)	Intraspecific	Linkage Mapping	Kim M; Cui ML; Cubas P ; et al. (2008) Regulatory genes control a key morphological and ecological trait transferred between species.	GP00000194	CYC O49250	Morphology	Gene gain by hybridization	Senecio vulgaris (species)	Senecio vulgaris (species)	CYC-like RAY1/RAY2	Senecio vulgaris (species)	Published - Accepted by Curator
CYCD5;1	Endoreduplication	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sterken R; Kiekens R; Boruc J ; et al. (2012) Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoredupl[...]	GP00000196	CYCD5-1 Q2V3B2	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CYCD5;1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Cycloidea (Lcyc)	Flower morphology	Cis-regulatory, Epigenetic Change	Linaria vulgaris common toadflax - (species) D	Intraspecific	Linkage Mapping	Cubas P; Vincent C; Coen E (1999) An epigenetic mutation responsible for natural variation in floral symmetry.	GP00000197	CYC O49250	Morphology	Stable methylation	Linaria vulgaris common toadflax - (species)	Linaria vulgaris common toadflax - (species) D	Cycloidea (Lcyc)	Linaria vulgaris common toadflax - (species)	Published - Accepted by Curator
Cyp12d1	Xenobiotic resistance (caffeine tolerance)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Najarro MA; Hackett JL; Smith BR ; et al. (2015) Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.	GP00000198	Cyp12d1-d Q7KR10	Physiology	Copy number Variant	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Cyp12d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP1A2	Enzymatic activity	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Murayama N; Soyama A; Saito Y ; et al. (2004) Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]	GP00000199	CYP1A2 P05177	Physiology	F186L	Homo sapiens human - (species)	Homo sapiens human - (species)	CYP1A2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP2C9	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000200	CYP2C9 P11712	Physiology	I359L	Homo sapiens human - (species)	Homo sapiens human - (species)	CYP2C9	Homo sapiens human - (species)	Published - Accepted by Curator
CYP4F2	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000203	CYP4F2 P78329	Physiology	V433M	Homo sapiens human - (species)	Homo sapiens human - (species)	CYP4F2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP6AB3	Xenobiotic resistance (imperatorin)	Coding, SNP	Depressaria pastinacella (species)	Intraspecific	Candidate Gene	Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007) Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]	GP00000204	CYP6AB3 Q7YZS3	Physiology	Ala92Val (and potentiallly 4 other a.a. substitutions)	Depressaria pastinacella (species)	Depressaria pastinacella (species)	CYP6AB3	Depressaria pastinacella (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chung H; Bogwitz MR; McCart C ; et al. (2007) Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]	GP00000207	Cyp6g1 Q9V674	Physiology	Insertion of retrotransposon A 291bp upstream of the Cyp6g1 transcription start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	cyp6g1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)	Xenobiotic resistance (insecticide)	Unknown, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Riveron JM; Irving H; Ndula M ; et al. (2013) Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...]	GP00000208	CYP2C9 P11712	Physiology	unknown but strong evidence of directional selection at these genes correlated with elevated expression	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9 cluster (CYP6P9a and CYP6P9b)	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP6P9; CYP6P4 cluster	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Wondji CS; Irving H; Morgan J ; et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...]	GP00000209	Q2YH43	Physiology	unknown; but 10-30 fold differences in expression levels between phenotypes	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9; CYP6P4 cluster	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP79D15	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000211	CYP79D15 B2Y2T9	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D	CYP79D15	Trifolium repens white clover - (species)	Published - Accepted by Curator
CYP81F2	Glucosinolate content Herbivore resistance (aphids)	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pfalz M; Vogel H; Kroymann J (2009) The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole gluco[...]	GP00000212	CYP81F2 Q9LVD6	Physiology Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CYP81F2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Dca (=smp-30)	Wing size	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lee SF; Chen Y; Varan AK ; et al. (2011) Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence a[...]	GP00000214	smp-30 Q9VFG5	Morphology	Non-coding	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Dca (=smp-30)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Delta	Bristle number (abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Langley CH ; et al. (1998) Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in [...] 1 Additional References Genissel A; Pastinen T; Dowell A (2004) No evidence for an association between common nonsynonymous polymorphisms in delta and bristle numbe[...]	GP00000216	Dl P10041	Morphology	unknown; associated site in intron 5	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Delta	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Delta	Bristle number (thorax)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Long AD; Lyman RF; Langley CH ; et al. (1998) Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in [...] 1 Additional References Genissel A; Pastinen T; Dowell A (2004) No evidence for an association between common nonsynonymous polymorphisms in delta and bristle numbe[...]	GP00000217	Dl P10041	Morphology	unknown; associated site in intron 2	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Delta	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
desaturase 2 (desat2)	Pheromone production	Cis-regulatory, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Takahashi A; Tsaur SC; Coyne JA ; et al. (2001) The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila m[...] 1 Additional References Dallerac R; Labeur C; Jallon JM (2000) A delta 9 desaturase gene with a different substrate specificity is responsible for the cuticular di[...]	GP00000221	Desat2 Q9VG68	Physiology	16bp deletion about 150bp upstream of transcription start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	desaturase 2 (desat2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (flowers)	Coding, Deletion	Iochroma calycinum (species) D	Intraspecific	Candidate Gene	Coburn RA; Griffin RH; Smith SD (2015) Genetic basis for a rare floral mutant in an Andean species of Solanaceae.	GP00000224	DFRA P51102	Morphology	33bp (11 a.a) deletion In coding sequence	Iochroma calycinum (species)	Iochroma calycinum (species) D	dihydroflavonol reductase (DFR)	Iochroma calycinum (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Unckless RL; Rottschaefer SM; Lazzaro BP (2015) The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster. 1 Additional References Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.	GP00000227	DptA P24492	Physiology	Ser>Arg (AGC>AGA)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Diptericin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila. 1 Additional References Unckless RL; Lazzaro BP (2016) The potential for adaptive maintenance of diversity in insect antimicrobial peptides.	GP00000228	DptA P24492	Physiology	Ser>Arg (AGC>AGG)	Drosophila simulans (species)	Drosophila simulans (species)	Diptericin	Drosophila simulans (species)	Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)	Seed dormancy	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Bentsink L; Jowett J; Hanhart CJ ; et al. (2006) Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis. 3 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Horton MW; Hancock AM; Huang YS (2012) Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegM[...] Nakabayashi K; Bartsch M; Ding J (2015) Seed Dormancy in Arabidopsis Requires Self-Binding Ability of DOG1 Protein and the Presence of Multi[...]	GP00000231	DOG1 A0SVK0	Physiology	Not identified (possibly polyallelic as each cross to the Ler accession showed different DOG1 effects)	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	DOG1 (DELAY OF GERMINATION 1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Dopa-decarboxylase	Bristle number (abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Mackay TF; Lyman RF (2005) Drosophila bristles and the nature of quantitative genetic variation.	GP00000232	Ddc P05031	Morphology	Promoter variation	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Dopa-decarboxylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Dopa-decarboxylase	Longevity	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	De Luca M; Roshina NV; Geiger-Thornsberry GL ; et al. (2003) Dopa decarboxylase (Ddc) affects variation in Drosophila longevity.	GP00000233	Ddc P05031	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Dopa-decarboxylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Drip	Fertility	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Bergland AO; Chae HS; Kim YJ ; et al. (2012) Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression an[...]	GP00000237	Drip Q9V5Z7	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Drip	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Duffy	Pathogen resistance (Plasmodium; malaria parasite) (malaria)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Tournamille C; Colin Y; Cartron JP ; et al. (1995) Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-n[...]	GP00000240	ACKR1 Q16570	Physiology	T to C substitution in 5' region at pos -46	Homo sapiens human - (species)	Homo sapiens human - (species)	Duffy	Homo sapiens human - (species)	Published - Accepted by Curator
DYM	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000242	DYM Q7RTS9	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	DYM	Homo sapiens human - (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)	Flowering time	Coding, Indel	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jiménez-Gómez JM; Wallace AD; Maloof JN (2010) Network analysis identifies ELF3 as a QTL for the shade avoidance response in Arabidopsis. 3 Additional References Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...] Coluccio MP; Sanchez SE; Kasulin L (2011) Genetic mapping of natural variation in a shade avoidance response: ELF3 is the candidate gene for a[...] Undurraga SF; Press MO; Legendre M (2012) Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3.	GP00000244	ELF3 O82804	Physiology	Background-dependent effects of extensive polyQ coding variation	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	EARLY FLOWERING 3(ELF3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ebony	Coloration (abdomen)	Cis-regulatory, Unknown	Drosophila novamexicana (species) D	Intraspecific	Linkage Mapping	Wittkopp PJ; Stewart EE; Arnold LL ; et al. (2009) Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.	GP00000248	e O76858	Morphology	Not identified	Drosophila americana (species)	Drosophila novamexicana (species) D	ebony	Drosophila novamexicana (species)	Published - Accepted by Curator
ebony	Coloration (thorax)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Takahashi A; Takahashi K; Ueda R ; et al. (2007) Natural variation of ebony gene controlling thoracic pigmentation in Drosophila melanogaster.	GP00000249	e O76858	Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	Cis-regulatory, Unknown	Drosophila auraria (species) D	Intraspecific	Candidate Gene	Johnson WC; Ordway AJ; Watada M ; et al. (2015) Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and betwee[...]	GP00000250	e O76858	Morphology	Inactivation of a conserved silencer resulting in gain-of-expression; the increase in ebony expression in the light strain occurred primarily through mutations affecting the ebony male-specific silencer element	Drosophila auraria (species)	Drosophila auraria (species) D	ebony	Drosophila auraria (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Takahashi A; Takano-Shimizu T (2011) Divergent enhancer haplotype of ebony on inversion In(3R)Payne associated with pigmentation variatio[...]	GP00000252	e O76858	Morphology	17 nucleotide sites and 2 indels in complete association with the thoracic trident pigmentation intensity in a 13kb region	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ebony	Coloration (posterior abdomen)	5 Mutations: Cis-regulatory SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Rebeiz M; Pool JE; Kassner VA ; et al. (2009) Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population.	GP00000253	e O76858	Morphology	5 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	ebony	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
EDAR	Ear shape	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Adhikari K; Reales G; Smith AJ ; et al. (2015) A genome-wide association study identifies multiple loci for variation in human ear morphology.	GP00000255	EDAR Q9UNE0	Morphology	Val370Ala	Homo sapiens human - (species)	Homo sapiens human - (species)	EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EDAR	Hair thickness Eccrine gland density	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Fujimoto A; Kimura R; Ohashi J ; et al. (2008) A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickne[...] 1 Additional References Kamberov YG; Wang S; Tan J (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant.	GP00000256	EDAR Q9UNE0	Morphology Morphology	Val370Ala; functionally validated in mouse	Homo sapiens human - (species)	Homo sapiens human - (species)	EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EDAR	Tooth shape	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kimura R; Yamaguchi T; Takeda M ; et al. (2009) A common variation in EDAR is a genetic determinant of shovel-shaped incisors.	GP00000257	EDAR Q9UNE0	Morphology	Val370Ala	Homo sapiens human - (species)	Homo sapiens human - (species)	EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EGFR	Wing Shape	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Dworkin I; Palsson A; Gibson G (2005) Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster. 1 Additional References Palsson A; Dodgson J; Dworkin I (2005) Tests for the replication of an association between Egfr and natural variation in Drosophila melanog[...]	GP00000259	Egfr P04412	Morphology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	EGFR	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
egl-4 (Ppa-egl-4)	Insect pheromone attraction	Unknown, Unknown	Pristionchus pacificus (species)	Intraspecific	Association Mapping	Hong RL; Witte H; Sommer RJ (2008) Natural variation in Pristionchus pacificus insect pheromone attraction involves the protein kinase [...]	GP00000260	egl-4 O76360	Behavior	unknown	Pristionchus pacificus (species)	Pristionchus pacificus (species)	egl-4 (Ppa-egl-4)	Pristionchus pacificus (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 3 Additional References Bigham A; Bauchet M; Pinto D (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...] Xu S; Li S; Yang Y (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans. Xiang K; Ouzhuluobu ; Peng Y (2013) Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high[...]	GP00000261	EGLN1 Q9GZT9	Physiology	possibly D4E	Homo sapiens human - (species)	Homo sapiens human - (species)	EGLN1	Homo sapiens human - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Bigham A; Bauchet M; Pinto D ; et al. (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...]	GP00000262	EGLN1 Q9GZT9	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	EGLN1	Homo sapiens human - (species)	Published - Accepted by Curator
EIF2AK3	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000264	EIF2AK3 Q9NZJ5	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	EIF2AK3	Homo sapiens human - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000267	END3 P39013	Physiology Physiology	S258N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000268	END3 P39013	Physiology Physiology	D268N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
EPAS1	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 1 Additional References Xu S; Li S; Yang Y (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans.	GP00000274	EPAS1 Q99814	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	EPAS1	Homo sapiens human - (species)	Published - Accepted by Curator
Epithiospecifier Modifier1 (ESM1)	Nitrile content	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Zhang Z; Ober JA; Kliebenstein DJ (2006) The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hy[...]	GP00000277	ESM1 Q9LJG3	Physiology	Not identified	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Epithiospecifier Modifier1 (ESM1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Epithiospecifier protein (ESP)	Plant secondary metabolite (glucosinolate) Herbivore resistance	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001) The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]	GP00000278	ESP Q8RY71	Physiology Physiology	Not identified	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Epithiospecifier protein (ESP)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Epithiospecifier protein (ESP)	Plant secondary metabolite (glucosinolate) Herbivore resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001) The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]	GP00000279	ESP Q8RY71	Physiology Physiology	deletion of 124 bases that eliminates a splice site and 100 nucleotides of the ORF N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Epithiospecifier protein (ESP)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ERECTA	Plant architecture Leaf architecture Transpiration	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Masle J; Gilmore SR; Farquhar GD (2005) The ERECTA gene regulates plant transpiration efficiency in Arabidopsis. 2 Additional References El-Lithy ME; Reymond M; Stich B (2010) Relation among plant growth, carbohydrates and flowering time in the Arabidopsis Landsberg erecta x [...] Huang X; Paulo MJ; Boer M (2011) Analysis of natural allelic variation in Arabidopsis using a multiparent recombinant inbred line pop[...]	GP00000280	ERECTA Q42371	Morphology Morphology Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	ERECTA	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000281	ERG11 P10613	Physiology	Y132H	Candida albicans (species)	Candida albicans (species) D	ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000282	ERG11 P10613	Physiology	S405F	Candida albicans (species)	Candida albicans (species) D	ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000283	ERG11 P10613	Physiology	G464S	Candida albicans (species)	Candida albicans (species) D	ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000284	ERG11 P10613	Physiology	R467K	Candida albicans (species)	Candida albicans (species) D	ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, Indel	Candida albicans (species)	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00000285	ERG11 P10613	Physiology	Copy number Variant	Candida albicans (species)	Candida albicans (species)	ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
esterase B1	Xenobiotic resistance (insecticide; benzoylurea)	Gene Amplification, Complex Change	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Karunaratne SH; Vaughan A; Paton MG ; et al. (1998) Amplification of a serine esterase gene is involved in insecticide resistance in Sri Lankan Culex tr[...]	GP00000290	B1 P16854	Physiology	Whole gene amplification	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	esterase B1	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
esterase B1 + esterase A	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Rooker S; Guillemaud T; Bergé J ; et al. (1996) Coamplification of esterase A and B genes as a single unit in Culex pipiens mosquitoes.	GP00000291	B1 P16854	Physiology	Amplification of a region containing both genes	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	esterase B1 + esterase A	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase B1 = esterase beta1	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Mouchès C; Pasteur N; Bergé JB ; et al. (1986) Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mo[...] 3 Additional References Guillemaud T; Raymond M; Tsagkarakou A (1999) Quantitative variation and selection of esterase gene amplification in Culex pipiens. Mouches C; Pauplin Y; Agarwal M (1990) Characterization of amplification core and esterase B1 gene responsible for insecticide resistance i[...] Guillemaud T; Rooker S; Pasteur N (1996) Testing the unique amplification event and the worldwide migration hypothesis of insecticide resista[...]	GP00000292	B1 P16854	Physiology	Amplification of esterase B1 only	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	esterase B1 = esterase beta1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
esterase E4	Xenobiotic resistance (insecticide)	Gene Amplification, Complex Change	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Field LM; Devonshire AL; Forde BG (1988) Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results[...]	GP00000293	P35501	Physiology	Whole gene amplification	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	esterase E4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Newcomb RD; Campbell PM; Ollis DL ; et al. (1997) A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]	GP00000294	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)	esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Jackson CJ; Liu JW; Carr PD ; et al. (2013) Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]	GP00000295	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)	esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species)	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000296	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species)	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000297	LcaE7 Q25252	Physiology	Trp251Ser	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000298	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D	esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E7 = E3	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Claudianos C; Russell RJ; Oakeshott JG (1999) The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]	GP00000299	LcaE7 Q25252	Physiology	Gly137Asp	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	esterase isozyme E7 = E3	Musca domestica house fly - (species)	Published - Accepted by Curator
exp-1	Aggregation behavior	Cis-regulatory, Unknown	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Bendesky A; Pitts J; Rockman MV ; et al. (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...]	GP00000300	exp-1 G5ECJ0	Behavior	unidentified; 6.2kb wide genetic interval 3' of the exp-1 gene	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	exp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
FAAH	Anxiety (fear reduction)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Dincheva I; Drysdale AT; Hartley CA ; et al. (2015) FAAH genetic variation enhances fronto-amygdala function in mouse and human.	GP00000301	Faah P97612	Behavior	Pro129Thr (C385A; common variant rs324420)	Homo sapiens human - (species)	Homo sapiens human - (species)	FAAH	Homo sapiens human - (species)	Published - Accepted by Curator
FAR (pheromone gland FAR)	Pheromone production (isomeric/chirality divergence)	Coding, Unknown	Ostrinia nubilalis European corn borer - (species)	Intraspecific	Linkage Mapping	Lassance JM; Groot AT; Liénard MA ; et al. (2010) Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones. 1 Additional References Lassance JM; Liénard MA; Antony B (2013) Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia [...]	GP00000304	pgFAR D3U9W3	Physiology	Candidate a.a. substitutions with effect validated in vitro	Ostrinia nubilalis European corn borer - (species)	Ostrinia nubilalis European corn borer - (species)	FAR (pheromone gland FAR)	Ostrinia nubilalis European corn borer - (species)	Published - Accepted by Curator
FGFR2	Hair thickness	Cis-regulatory, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Fujimoto A; Nishida N; Kimura R ; et al. (2009) FGFR2 is associated with hair thickness in Asian populations.	GP00000314	FGFR2 P21802	Morphology	Unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	FGFR2	Homo sapiens human - (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000315	CYP75B1 Q9SD85	Morphology	-1bp at +973 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D	Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000316	CYP75B1 Q9SD85	Morphology	-1bp at +1164 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D	Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Indel	Glycine soja (species)	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000317	CYP75B1 Q9SD85	Morphology	a single base insertion of an adenine at position 965 as well as a single base deletion of adenine at position 973 resulting in N322K and Q324T - exact causing mutation(s) unknown	Glycine max soybean - (species)	Glycine soja (species)	Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers; pubescence; seeds)	Coding, Insertion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000322	CYP75A2 P37120	Morphology	53bp insertion at +1352 N	Glycine max soybean - (species)	Glycine soja (species) D	flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, SNP	Glycine soja (species)	Intraspecific	Linkage Mapping	Takahashi R; Dubouzet JG; Matsumura H ; et al. (2010) A new allele of flower color gene W1 encoding flavonoid 3'5'-hydroxylase is responsible for light pu[...]	GP00000323	CYP75A2 P37120	Morphology	V210M (uncertain); no expression level differences detected	Glycine max soybean - (species)	Glycine soja (species)	flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Cis-regulatory, Unknown	Phlox drummondii (species)	Intraspecific	Linkage Mapping	Hopkins R; Rausher MD (2011) Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii.	GP00000325	CYP75A2 P37120	Morphology	unknown	Phlox drummondii (species)	Phlox drummondii (species)	flavonoid 3';5'-hydroxylase (F3'5'H)	Phlox drummondii (species)	Published - Accepted by Curator
FLC (=Pep1)	Flowering time	Gene Amplification, Indel	Arabis alpina gray rockcress - (species)	Intraspecific	Candidate Gene	Albani MC; Castaings L; Wötzel S ; et al. (2012) PEP1 of Arabis alpina is encoded by two overlapping genes that contribute to natural genetic variati[...]	GP00000329	FLC Q9S7Q7	Physiology	complex structural variations	Arabis alpina gray rockcress - (species)	Arabis alpina gray rockcress - (species)	FLC (=Pep1)	Arabis alpina gray rockcress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000330	FLC Q9S7Q7	Physiology	Substitution creating premature Stop (codon 158) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	2 Mutations: Cis-regulatory SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Coustham V; Li P; Strange A ; et al. (2012) Quantitative modulation of polycomb silencing underlies natural variation in vernalization. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000331	FLC Q9S7Q7	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Insertion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Michaels SD; He Y; Scortecci KC ; et al. (2003) Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...] 2 Additional References Gazzani S; Gendall AR; Lister C (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions. Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000332	FLC Q9S7Q7	Physiology	TE insertion in intron 1; a region required for normal FLC regulation	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Michaels SD; He Y; Scortecci KC ; et al. (2003) Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...] 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000333	FLC Q9S7Q7	Physiology	Not identified	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000334	FLC Q9S7Q7	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000335	FLC Q9S7Q7	Physiology	GA substitution disrupting Splice Site	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Sánchez-Bermejo E; Méndez-Vigo B; Picó FX ; et al. (2012) Novel natural alleles at FLC and LVR loci account for enhanced vernalization responses in Arabidopsi[...] 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000336	FLC Q9S7Q7	Physiology	50bp deletion in 5'UTR	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Capsella rubella (species)	Intraspecific	Linkage Mapping	Guo YL; Todesco M; Hagmann J ; et al. (2012) Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella[...]	GP00000337	FLC Q9S7Q7	Physiology	Splice site mutation introducing frameshift; removing the last 35 of 198 amino acids	Capsella rubella (species)	Capsella rubella (species)	FLC (Flowering Locus C)	Capsella rubella (species)	Published - Accepted by Curator
FLM (MAF1)	Flowering time	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Warthmann N ; et al. (2005) Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for[...]	GP00000341	AGL27 Q9AT76	Physiology	Deletion of entire gene N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FLM (MAF1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
foraging	Food-search behavior	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Osborne KA; Robichon A; Burgess E ; et al. (1997) Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. 1 Additional References Mery F; Belay AT; So AK (2007) Natural polymorphism affecting learning and memory in Drosophila.	GP00000350	for Q03043	Behavior	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	foraging	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
FPN2	Metal tolerance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Morrissey J; Baxter IR; Lee J ; et al. (2009) The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.	GP00000354	IREG2 F4KGN5	Physiology	1bp insertion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	FPN2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pineau C; Loubet S; Lefoulon C ; et al. (2012) Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Z[...]	GP00000355	DTX43 Q9SFB0	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]	GP00000357	FRI P0DH90	Physiology	16bp deletion aa313-318 in exon 2 and premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000358	FRI P0DH90	Physiology	376 bp deletion and 31 bp insertion that delete amino acid 1-15 and at best produce a 45-aa protein N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000359	FRI P0DH90	Physiology	Del 2257-2355 in exon 3; deletion of 99 bp combined with an insertion of 61 bp N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000360	FRI P0DH90	Physiology	1bp deletion at 1487 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000361	FRI P0DH90	Physiology	1bp insertion at 766 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000362	FRI P0DH90	Physiology	Insertion 1 bp at 1454 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000363	FRI P0DH90	Physiology	Trp240* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000364	FRI P0DH90	Physiology	Glu361* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gazzani S; Gendall AR; Lister C ; et al. (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.	GP00000365	FRI P0DH90	Physiology	K232* in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000366	FRI P0DH90	Physiology	deletion; E430* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000367	FRI P0DH90	Physiology	deletion of 6 amino acids; LQLDKE422-427*	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000368	FRI P0DH90	Physiology	deletion aa 1-12	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000369	FRI P0DH90	Physiology	deletion resulting in S121* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000370	FRI P0DH90	Physiology	deletion; AF375-6* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000371	FRI P0DH90	Physiology	insertion; I490* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000372	FRI P0DH90	Physiology	insertion; T258* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000373	FRI P0DH90	Physiology	Y162* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000374	FRI P0DH90	Physiology	K170* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time Water use efficiency	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Lovell JT; Juenger TE; Michaels SD ; et al. (2013) Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation.	GP00000375	FRI P0DH90	Physiology Physiology	376 bp deletion within the promoter of the TSU-1 FRI allele	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 1 (FRL1)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000376	FRL1 Q9FFF1	Physiology	E279* in the middle of the conceptual protein sequence N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida like 1 (FRL1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 2 (FRL2)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000377	FRL2 Q9C6S2	Physiology	A132P and/or L401Q	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Frigida like 2 (FRL2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FTO	Body size (weight; variance)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Frayling TM; Timpson NJ; Weedon MN ; et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and[...] 4 Additional References Dina C; Meyre D; Gallina S (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Scuteri A; Sanna S; Chen WM (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-rela[...] Yang J; Loos RJ; Powell JE (2012) FTO genotype is associated with phenotypic variability of body mass index. Claussnitzer M; Dankel SN; Kim KH (2015) FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.	GP00000378	FTO Q9C0B1	Morphology; Physiology	rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor	Homo sapiens human - (species)	Homo sapiens human - (species)	FTO	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...]	GP00000379	FUT2 Q10981	Physiology	9.3 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 2 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...] Koda Y; Soejima M; Johnson PH (2000) An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype.	GP00000380	FUT2 Q10981	Physiology	10 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000381	FUT2 Q10981	Physiology	premature stop at codon 143: TGG>TGA N	Homo sapiens human - (species)	Homo sapiens human - (species)	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000382	FUT2 Q10981	Physiology	Ile129Phe	Homo sapiens human - (species)	Homo sapiens human - (species)	FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
GDF5	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sanna S; Jackson AU; Nagaraja R ; et al. (2008) Common variants in the GDF5-UQCC region are associated with variation in human height. 1 Additional References Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000387	GDF5 P43026	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	GDF5	Homo sapiens human - (species)	Published - Accepted by Curator
GDF6	Dermal bone size (armor plates)	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Indjeian VB; Kingman GA; Jones FC ; et al. (2016) Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.	GP00000388	GDF6 Q6KF10	Morphology	gain of a flank enhancer activity involving a complex repeat region; 1.2kb L2 LINE insertion; 18 small indels and 89 SNPs - the LINE insertion is required but not sufficient, to produce increased flank expression	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	GDF6	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
GHSR	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000394	GHSR Q92847	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	GHSR	Homo sapiens human - (species)	Published - Accepted by Curator
GIBBERELLIC ACID REQUIRING 1 (GA1)	Flower morphology	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Brock MT; Kover PX; Weinig C (2012) Natural variation in GA1 associates with floral morphology in Arabidopsis thaliana.	GP00000395	GA1 Q38802	Morphology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	GIBBERELLIC ACID REQUIRING 1 (GA1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome (leaves)	Unknown, Unknown	Arabidopsis (genus)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Kivimäki M; Kärkkäinen K; Gaudeul M (2007) Gene, phenotype and function: GLABROUS1 and resistance to herbivory in natural populations of Arabid[...]	GP00000398	GL1 P27900	Morphology	unknown	Arabidopsis (genus)	Arabidopsis (genus)	GLABROUS1	Arabidopsis (genus)	Published - Accepted by Curator
glb-5	CO2 avoidance Aggregation behavior	Coding, Indel N	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	McGrath PT; Rockman MV; Zimmer M ; et al. (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] 2 Additional References Bendesky A; Pitts J; Rockman MV (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...] Persson A; Gross E; Laurent P (2009) Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.	GP00000399	glb-5 A3RMS5	Behavior Behavior	765bp insertion/duplication resulting in a truncation of the last 179 amino acids of the protein and the inclusion of 40 different residues N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	glb-5	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLC-1	Xenobiotic resistance (antihelmintics)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Ghosh R; Andersen EC; Shapiro JA ; et al. (2012) Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.	GP00000400	glc-1 G5EBR3	Physiology	4aa deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	GLC-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000401	G6PD P11413	Physiology	Ser188Phe C>T	Homo sapiens human - (species)	Homo sapiens human - (species)	Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Louicharoen C; Patin E; Paul R ; et al. (2009) Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.	GP00000402	G6PD P11413	Physiology	Ser163Gly	Homo sapiens human - (species)	Homo sapiens human - (species)	Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000403	G6PD P11413	Physiology	Val68Met G>A at nucleotide position 376 in exon 5 - OMIM code +305900.0002	Homo sapiens human - (species)	Homo sapiens human - (species)	Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-dependent insulinotropic polypeptide	Glycemia Adipolysis rate	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chang CL; Cai JJ; Lo C ; et al. (2011) Adaptive selection of an incretin gene in Eurasian populations.	GP00000404	GIP P09681	Physiology Physiology	Ser103Gly	Homo sapiens human - (species)	Homo sapiens human - (species)	Glucose-dependent insulinotropic polypeptide	Homo sapiens human - (species)	Published - Accepted by Curator
Glycophorin GYPA-GYPB-GYPE cluster	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	; Band G; Rockett KA ; et al. (2015) A novel locus of resistance to severe malaria in a region of ancient balancing selection.	GP00000406	GYPA P02724	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	Glycophorin GYPA-GYPB-GYPE cluster	Homo sapiens human - (species)	Published - Accepted by Curator
GNBP1	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sackton TB; Lazzaro BP; Clark AG (2010) Genotype and gene expression associations with immune function in Drosophila.	GP00000408	GNBP1 Q9NHB0	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	GNBP1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GNBP2	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sackton TB; Lazzaro BP; Clark AG (2010) Genotype and gene expression associations with immune function in Drosophila.	GP00000409	GNBP2 Q9VVR4	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	GNBP2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GPR133	Body size (height; male-limited)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tönjes A; Koriath M; Schleinitz D ; et al. (2009) Genetic variation in GPR133 is associated with height: genome wide association study in the self-con[...]	GP00000412	ADGRD1 Q6QNK2	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	GPR133	Homo sapiens human - (species)	Published - Accepted by Curator
Growth Hormone Receptor	Body size (height)	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000415	GHR P10912	Morphology	Arg61* N	Homo sapiens human - (species)	Homo sapiens human - (species)	Growth Hormone Receptor	Homo sapiens human - (species)	Published - Accepted by Curator
GSTE1-E10 cluster	Xenobiotic resistance (drug)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kislukhin G; King EG; Walters KN ; et al. (2013) The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.	GP00000419	GstE1 Q7KK90	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	GSTE1-E10 cluster	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000426	ABCA2 A0A0S0G7V0	Physiology	Pro53* (161T>A) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...] 2 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000427	ABCA2 A0A0S0G7V0	Physiology	10kb deletion N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000428	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000429	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000430	ABCA2 A0A0S0G7V0	Physiology	Insertion of an incomplete RNA transposon (1498bp) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000431	ABCA2 A0A0S0G7V0	Physiology	Insertion of a DNA transposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000432	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000433	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
HAC1 (=ATQ1)	Xenobiotic resistance (soil contamination; arsenate)	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sánchez-Bermejo E; Castrillo G; del Llano B ; et al. (2014) Natural variation in arsenate tolerance identifies an arsenate reductase in Arabidopsis thaliana. 1 Additional References Chao DY; Chen Y; Chen J (2014) Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]	GP00000434	HAC1 Q9C5X9	Physiology	Coding variation and differential gene expression in roots	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	HAC1 (=ATQ1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HAC1 (=ATQ1)	Xenobiotic resistance (soil contamination; arsenate)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Chen Y; Chen J ; et al. (2014) Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]	GP00000435	HAC1 Q9C5X9	Physiology	1bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	HAC1 (=ATQ1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
hairy (h)	Bristle number (thorax)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Robin C; Lyman RF; Long AD ; et al. (2002) hairy: A quantitative trait locus for drosophila sensory bristle number.	GP00000436	h P14003	Morphology	unknown; complex promoter indel variation shows high-association	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	hairy (h)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000443	HMA3 P0CW78	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000444	HMA3 P0CW78	Physiology	1-bp deletion resulting in a premature stop codon resulting in hypofunctional transporter. This is a high-frequency allele; suggesting the hyper-functional alleles are only selected in Cd-rich soils N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Gene Amplification, Complex Change	Noccaea caerulescens (species)	Intraspecific	Candidate Gene	Ueno D; Milner MJ; Yamaji N ; et al. (2011) Elevated expression of TcHMA3 plays a key role in the extreme Cd tolerance in a Cd-hyperaccumulating[...]	GP00000446	HMA3 P0CW78	Physiology	Copy number Variant	Noccaea caerulescens (species)	Noccaea caerulescens (species)	heavy metal atpase3 (HMA3)	Noccaea caerulescens (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000450	HMA5 Q9SH30	Physiology	P626L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000451	HMA5 Q9SH30	Physiology	N923T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000452	hecw-1 G5EEJ0	Behavior	Y322C	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000453	hecw-1 G5EEJ0	Behavior	Q325P	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
hemoglobin; HBA-T1 and T2 paralogues	Hypoxia response	5 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Sabatino SJ; Hoffmann FG ; et al. (2007) The molecular basis of high-altitude adaptation in deer mice. 2 Additional References Storz JF; Kelly JK (2008) Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights [...] Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000456	HBA1 P69905	Physiology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D	hemoglobin; HBA-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas cyanoptera cinnamon teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000457	HBA1 P69905	Physiology	Asn9Ser	Anas cyanoptera cinnamon teal - (species)	Anas cyanoptera cinnamon teal - (species) D	hemoglobin; HBA2	Anas cyanoptera cinnamon teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000458	HBA1 P69905	Physiology	Ala77Thr	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D	hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000459	HBAD P02001	Physiology	Ser130Phe	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D	hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000460	HBA1 P69905	Physiology	Ala77Thr	Anas versicolor (species)	Anas puna (species) D	hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000463	HBA1 P69905	Physiology	Ala5Thr	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D	hemoglobin; HBA2	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Merganetta armata (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000464	HBA1 P69905	Physiology	Ala77Thr	Merganetta armata (species)	Merganetta armata (species) D	hemoglobin; HBA2	Merganetta armata (species)	Published - Accepted by Curator
hemoglobin; HBB	Pathogen resistance (Plasmodium; malaria parasite)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Jallow M; Teo YY; Small KS ; et al. (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa.	GP00000466	HBB P68871	Physiology	Glu6Val	Homo sapiens human - (species)	Homo sapiens human - (species)	hemoglobin; HBB	Homo sapiens human - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000467	HBB P68871	Physiology	2 mutations	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D	hemoglobin; HBB	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas georgica yellow-billed pintail - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000468	HBB P68871	Physiology	2 mutations	Anas ducks - (genus)	Anas georgica yellow-billed pintail - (species) D	hemoglobin; HBB	Anas georgica yellow-billed pintail - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas puna (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000469	HBB P68871	Physiology	2 mutations	Anas ducks - (genus)	Anas puna (species) D	hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000470	HBB P68871	Physiology	2 mutations	Anatidae waterfowl - (family)	Lophonetta specularioides crested duck - (species) D	hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000472	HBB P68871	Physiology	Asp94Glu	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D	hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB-T1 and T2 paralogues	Hypoxia response	4 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Runck AM; Sabatino SJ ; et al. (2009) Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer [...] 1 Additional References Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000476	HBB P68871	Physiology	4 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D	hemoglobin; HBB-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBB/HBD fusion gene	Temperature tolerance (cold)	3 Mutations: Coding SNP	Mammuthus primigenius woolly mammoth - (species)	Intraspecific	Candidate Gene	Campbell KL; Roberts JE; Watson LN ; et al. (2010) Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance[...]	GP00000477	HBB P68871	Physiology	3 mutations	Elephantidae elephants - (family)	Mammuthus primigenius woolly mammoth - (species)	hemoglobin; HBB/HBD fusion gene	Mammuthus primigenius woolly mammoth - (species)	Published - Accepted by Curator
HLA-DQA1	Histocompatibility	Cis-regulatory, Unknown	Papio baboons - (genus)	Intraspecific	Candidate Gene	Loisel DA; Rockman MV; Wray GA ; et al. (2006) Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region.	GP00000478	HLA-DQA1 P01909	Physiology	Promoter variation	Papio baboons - (genus)	Papio baboons - (genus)	HLA-DQA1	Papio baboons - (genus)	Published - Accepted by Curator
HLA-DRB1	Pathogen resistance (typhoid fever)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Dunstan SJ; Hue NT; Han B ; et al. (2014) Variation at HLA-DRB1 is associated with resistance to enteric fever.	GP00000479	HLA-DRB1 Q30167	Physiology	uncharacterized	Homo sapiens human - (species)	Homo sapiens human - (species)	HLA-DRB1	Homo sapiens human - (species)	Published - Accepted by Curator
HMGA2	Body size (height) ; Bone mineral density	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Weedon MN; Lettre G; Freathy RM ; et al. (2007) A common variant of HMGA2 is associated with adult and childhood height in the general population. 3 Additional References Yang TL; Guo Y; Zhang LS (2010) HMGA2 is confirmed to be associated with human adult height. Kuipers A; Zhang Y; Cauley JA (2009) Association of a high mobility group gene (HMGA2) variant with bone mineral density. Horikoshi M; Yaghootkar H; Mook-Kanamori DO (2013) New loci associated with birth weight identify genetic links between intrauterine growth[...]	GP00000486	HMGA2 P52926	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	HMGA2	Homo sapiens human - (species)	Published - Accepted by Curator
HUA2	Flowering time Shoot morphology	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Wang Q; Sajja U; Rosloski S ; et al. (2007) HUA2 caused natural variation in shoot morphology of A. thaliana.	GP00000491	HUA2 Q9XER9	Physiology Morphology	K525E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Human Leukocyte Antigen-B (HLA-B)	Pathogen resistance (HIV control)	5 Mutations: Coding SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	; Pereyra F; Jia X ; et al. (2010) The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.	GP00000492	HLA-B P01889	Physiology	5 mutations	Homo sapiens human - (species)	Homo sapiens human - (species)	Human Leukocyte Antigen-B (HLA-B)	Homo sapiens human - (species)	Published - Accepted by Curator
IL4	Immune response	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Linkage Mapping	Rockman MV; Hahn MW; Soranzo N ; et al. (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression.	GP00000497	IL4 P05112	Physiology	_524T promoter single base-pair substitution affecting binding of the NFAT transcription factor	Homo sapiens human - (species)	Homo sapiens human - (species)	IL4	Homo sapiens human - (species)	Published - Accepted by Curator
IME1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00000498	IME1 P21190	Physiology	L325M and/or 1bp synonymous substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	IME1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Immune deficiency	Pathogen resistance	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sceurman BK; Clark AG (2004) Genetic basis of natural variation in D. melanogaster antibacterial immunity.	GP00000499	imd Q9NHG0	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Immune deficiency	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Insulin-like growth factor receptor 1 (IGF1)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000503	IGF1R P08069	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	Insulin-like growth factor receptor 1 (IGF1)	Homo sapiens human - (species)	Published - Accepted by Curator
JAZF1	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Johansson A; Marroni F; Hayward C ; et al. (2009) Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide assoc[...] 1 Additional References Soranzo N; Rivadeneira F; Chinappen-Horsley U (2009) Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations wi[...]	GP00000507	JAZF1 Q86VZ6	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	JAZF1	Homo sapiens human - (species)	Published - Accepted by Curator
KCNH4 - uncertain	Freshwater adaptation	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Association Mapping	Jones FC; Grabherr MG; Chan YF ; et al. (2012) The genomic basis of adaptive evolution in threespine sticklebacks.	GP00000510	KCNH4 Q9UQ05	Physiology	Large Inversion resulting in alternative transcripts	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	KCNH4 - uncertain	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
KCNQ1	Body size (height)	Unknown, Epigenetic Change	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000511	KCNQ1 P51787	Morphology	unknown causative change in an imprinted region - consistent with maternal inheritance detected by the association	Homo sapiens human - (species)	Homo sapiens human - (species)	KCNQ1	Homo sapiens human - (species)	Published - Accepted by Curator
KCS18	Oil composition	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jasinski S; Lécureuil A; Miquel M ; et al. (2012) Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]	GP00000512	FAE1 Q38860	Physiology	L407V N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	KCS18	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Kit ligand	Coloration (coat)	Cis-regulatory, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Miller CT; Beleza S; Pollen AA ; et al. (2007) cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...] 1 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans.	GP00000522	KITLG P21583	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	Kit ligand	Homo sapiens human - (species)	Published - Accepted by Curator
Kit ligand	Coloration (gills; ventrum)	Cis-regulatory, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Linkage Mapping	Miller CT; Beleza S; Pollen AA ; et al. (2007) cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...]	GP00000523	KITLG P21583	Morphology	Not identified	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)	Kit ligand	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
L6	Pathogen resistance	Coding, Insertion N	Linum usitatissimum flax - (species)	Intraspecific	Linkage Mapping	Lawrence GJ; Finnegan EJ; Ayliffe MA ; et al. (1995) The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 an[...]	GP00000528	L6 Q40253	Physiology	Truncated protein due to insertion of a transposable element. Reversion to resistance among descendants of mutant X75 was associated with excision of the newly transposable element Ac. N	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species)	L6	Linum usitatissimum flax - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Linkage Mapping	Enattah NS; Sahi T; Savilahti E ; et al. (2002) Identification of a variant associated with adult-type hypolactasia. 1 Additional References Tishkoff SA; Reed FA; Ranciaro A (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000529	LCT P09848	Physiology	C-13910T	Homo sapiens human - (species)	Homo sapiens human - (species)	lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000530	LCT P09848	Physiology	C-13907G	Homo sapiens human - (species)	Homo sapiens human - (species)	lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe.	GP00000531	LCT P09848	Physiology	T-13915G	Homo sapiens human - (species)	Homo sapiens human - (species) D	lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactase (LCT)	Lactose tolerance (adult)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007) Convergent adaptation of human lactase persistence in Africa and Europe. 1 Additional References Breton G; Schlebusch CM; Lombard M (2014) Lactase persistence alleles reveal partial East African ancestry of southern African Khoe pastoralis[...]	GP00000532	LCT P09848	Physiology	G14010C ; In Khoe Pastoralist group lactase persistence (LP)-regulatory region 2 SNPs with greatest frequencies 13910C>T and 14010G>C	Homo sapiens human - (species)	Homo sapiens human - (species)	lactase (LCT)	Homo sapiens human - (species)	Published - Accepted by Curator
lactate dehydrogenase-B (Ldh-B)	Stress response	Cis-regulatory, Unknown	Fundulus heteroclitus mummichog - (species)	Intraspecific	Linkage Mapping	Schulte PM; Glemet HC; Fiebig AA ; et al. (2000) Adaptive variation in lactate dehydrogenase-B gene expression: role of a stress-responsive regulator[...]	GP00000533	ldhb P20373	Physiology	unknown - candidate 1 bp change in southern populatin generates mammary tumor virus glucocorticoid responsive element	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species)	lactate dehydrogenase-B (Ldh-B)	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
Latexin (Lxn)	Stem cell number (hematopoietic precursors)	Cis-regulatory, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Liang Y; Jansen M; Aronow B ; et al. (2007) The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in[...]	GP00000534	Lxn P70202	Morphology	Not identified	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Latexin (Lxn)	Mus musculus house mouse - (species)	Published - Accepted by Curator
LCORL	Body size	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Horikoshi M; Yaghootkar H; Mook-Kanamori DO ; et al. (2013) New loci associated with birth weight identify genetic links between intrauterine growth[...]	GP00000537	LCORL Q8N3X6	Morphology	Not identified	Homo sapiens human - (species)	Homo sapiens human - (species)	LCORL	Homo sapiens human - (species)	Published - Accepted by Curator
Ldia2 - Diaphanous-related formin	Shell chirality (coiling)	Coding, Deletion N	Lymnaea stagnalis great pond snail - (species) D	Intraspecific	Association Mapping	Davison A; McDowell GS; Holden JM ; et al. (2016) Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.	GP00000538	DIAPH1 O60610	Morphology	1bp deletion resulting in frame-shift (pseudogenization) N	Lymnaea stagnalis great pond snail - (species)	Lymnaea stagnalis great pond snail - (species) D	Ldia2 - Diaphanous-related formin	Lymnaea stagnalis great pond snail - (species)	Published - Accepted by Curator
LIN28B	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000548	LIN28B Q6ZN17	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	LIN28B	Homo sapiens human - (species)	Published - Accepted by Curator
Linamarase	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000549	LI P26205	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D	Linamarase	Trifolium repens white clover - (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000553	P08659	Physiology	T739G and C740G in exon 4; leading to one amino acid change - colour difference between the yellow- and orange-emitting luciferases is due entirely to S247G	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)	luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	2 Mutations: Coding SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000554	P08659	Physiology	2 mutations	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)	luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Opisthocomus hoazin (species) D	Intraspecific	Candidate Gene	Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.	GP00000556	LYZ1 P04421	Physiology	5 mutations	Aves birds - (class)	Opisthocomus hoazin (species) D	lysozyme	Opisthocomus hoazin (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Colobinae (subfamily)	Intraspecific	Candidate Gene	Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2) Adaptive evolution in the stomach lysozymes of foregut fermenters. 3 Additional References Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin. Swanson KW; Irwin DM; Wilson AC (1991) Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection. Messier W; Stewart CB (1997) Episodic adaptive evolution of primate lysozymes.	GP00000558	LYZ1 P04421	Physiology	5 mutations	Primates (order)	Colobinae (subfamily)	lysozyme	Colobinae (subfamily)	Published - Accepted by Curator
M	Pathogen resistance	Coding, Deletion	Linum usitatissimum flax - (species) D	Intraspecific	Linkage Mapping	Anderson PA; Lawrence GJ; Morrish BC ; et al. (1997) Inactivation of the flax rust resistance gene M associated with loss of a repeated unit within the l[...]	GP00000559	P93244	Physiology	426bp deletion, probably by unequal recombination	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species) D	M	Linum usitatissimum flax - (species)	Published - Accepted by Curator
Mac1	Virulence	Unknown, Unknown	Cryptococcus neoformans (species)	Intraspecific	Linkage Mapping	Lin X; Huang JC; Mitchell TG ; et al. (2006) Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha all[...]	GP00000560	CGB_D8050W E6R4R6	Physiology	unknown	Cryptococcus neoformans (species)	Cryptococcus neoformans (species)	Mac1	Cryptococcus neoformans (species)	Published - Accepted by Curator
MADS AFFECTING FLOWERING 2 (MAF2)	Flowering time	Cis-regulatory, Insertion	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Rosloski SM; Jali SS; Balasubramanian S ; et al. (2010) Natural diversity in flowering responses of Arabidopsis thaliana caused by variation in a tandem gen[...]	GP00000561	MAF2 Q84J38	Physiology	Insertion alleles - several	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	MADS AFFECTING FLOWERING 2 (MAF2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MAM1	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kroymann J; Textor S; Tokuhisa JG ; et al. (2001) A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chai[...] 3 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...] Züst T; Heichinger C; Grossniklaus U (2012) Natural enemies drive geographic variation in plant defenses.	GP00000562	MAM1 Q9FG67	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	MAM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MaMyb2	Coloration (flowers)	Cis-regulatory, Unknown	Diplacus aurantiacus (species)	Intraspecific	Linkage Mapping	Streisfeld MA; Young WN; Sobel JM (2013) Divergent selection drives genetic differentiation in an R2R3-MYB transcription factor that contribu[...]	GP00000563	Myb2 M9QXG2	Morphology	unknown expression-phenotype co-vary	Diplacus aurantiacus (species)	Diplacus aurantiacus (species)	MaMyb2	Diplacus aurantiacus (species)	Published - Accepted by Curator
MARVELD3	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Timmann C; Thye T; Vens M ; et al. (2012) Genome-wide association study indicates two novel resistance loci for severe malaria.	GP00000564	MARVELD3 Q96A59	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	MARVELD3	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000567	MC1R Q01726	Morphology	2bp deletion resulting in frameshift N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D	MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, SNP	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000568	MC1R Q01726	Morphology	Arg164Cys (position 160 in human; so this mutation resembles the human R160W hypomorphic human mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D	MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Vulpes lagopus Arctic fox - (species)	Intraspecific	Candidate Gene	Våge DI; Fuglei E; Snipstad K ; et al. (2005) Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) [...]	GP00000569	MC1R Q01726	Morphology	G5C	Vulpes lagopus Arctic fox - (species)	Vulpes lagopus Arctic fox - (species)	MC1R	Vulpes lagopus Arctic fox - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Vulpes lagopus Arctic fox - (species)	Intraspecific	Candidate Gene	Våge DI; Fuglei E; Snipstad K ; et al. (2005) Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) [...]	GP00000570	MC1R Q01726	Morphology	F280C	Vulpes lagopus Arctic fox - (species)	Vulpes lagopus Arctic fox - (species)	MC1R	Vulpes lagopus Arctic fox - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000576	MC1R Q01726	Morphology	R18C	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D	MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000577	MC1R Q01726	Morphology	R109W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D	MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000578	MC1R Q01726	Morphology	R160W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D	MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000579	MC1R Q01726	Morphology	Q233H	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D	MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Candidate Gene	Marklund L; Moller MJ; Sandberg K ; et al. (1996) A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated wit[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000580	MC1R Q01726	Morphology	S83F	Equus caballus horse - (species)	Equus caballus horse - (species)	MC1R	Equus caballus horse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Puma yagouaroundi jaguarundi - (species) D	Intraspecific	Candidate Gene	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000581	MC1R Q01726	Morphology	Deletion of aa 95-102	Puma yagouaroundi jaguarundi - (species)	Puma yagouaroundi jaguarundi - (species) D	MC1R	Puma yagouaroundi jaguarundi - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus poschiavinus (species)	Intraspecific	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000583	MC1R Q01726	Morphology	S69L	Mus musculus house mouse - (species)	Mus poschiavinus (species)	MC1R	Mus poschiavinus (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Wada A; Kunieda T; Nishimura M ; et al. (2005 Mar-Apr) A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred s[...]	GP00000586	MC1R Q01726	Morphology	W252C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Panthera onca jaguar - (species) D	Intraspecific	Candidate Gene	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000593	MC1R Q01726	Morphology	Deletion of aa 101-105 and L106T	Panthera onca jaguar - (species)	Panthera onca jaguar - (species) D	MC1R	Panthera onca jaguar - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Linkage Mapping	Hoekstra HE; Hirschmann RJ; Bundey RA ; et al. (2006) A single amino acid mutation contributes to adaptive beach mouse color pattern.	GP00000594	MC1R Q01726	Morphology	R65C	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)	MC1R	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Rattus rattus black rat - (species)	Intraspecific	Candidate Gene	Kambe Y; Tanikawa T; Matsumoto Y ; et al. (2011) Origin of agouti-melanistic polymorphism in Wild Black Rats (Rattus rattus) inferred from Mc1r gene [...]	GP00000595	MC1R Q01726	Morphology	Glu93Lys	Rattus tanezumi Oriental house rat - (species)	Rattus rattus black rat - (species)	MC1R	Rattus rattus black rat - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Sciurus carolinensis gray squirrel - (species) D	Intraspecific	Candidate Gene	McRobie H; Thomas A; Kelly J (2009 Nov-Dec) The genetic basis of melanism in the gray squirrel (Sciurus carolinensis).	GP00000596	MC1R Q01726	Morphology	Deletion of 8 a.a.	Sciurus carolinensis gray squirrel - (species)	Sciurus carolinensis gray squirrel - (species) D	MC1R	Sciurus carolinensis gray squirrel - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ursus americanus American black bear - (species)	Intraspecific	Candidate Gene	Ritland K; Newton C; Marshall HD (2001) Inheritance and population structure of the white-phased "Kermode" black bear.	GP00000597	MC1R Q01726	Morphology	Y298C	Ursus americanus American black bear - (species)	Ursus americanus American black bear - (species)	MC1R	Ursus americanus American black bear - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Anser caerulescens snow goose - (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000599	MC1R Q01726	Morphology	V85M	Anser caerulescens snow goose - (species)	Anser caerulescens snow goose - (species)	MC1R	Anser caerulescens snow goose - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Coereba flaveola Bananaquit - (species) D	Intraspecific	Candidate Gene	Theron E; Hawkins K; Bermingham E ; et al. (2001) The molecular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor point mu[...]	GP00000600	MC1R Q01726	Morphology	E92K	Coereba flaveola Bananaquit - (species)	Coereba flaveola Bananaquit - (species) D	MC1R	Coereba flaveola Bananaquit - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, Deletion	Falco eleonorae (species) D	Intraspecific	Candidate Gene	Gangoso L; Grande JM; Ducrest AL ; et al. (2011) MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the E[...]	GP00000603	MC1R Q01726	Morphology	Deletion of 3 a.a.	Falco eleonorae (species)	Falco eleonorae (species) D	MC1R	Falco eleonorae (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Falco rusticolus gyrfalcon - (species)	Intraspecific	Candidate Gene	Johnson JA; Ambers AD; Burnham KK (2012 May-Jun) Genetics of plumage color in the Gyrfalcon (Falco rusticolus): analysis of the melanocortin-1 recept[...]	GP00000604	MC1R Q01726	Morphology	Val128Ile	Falco rusticolus gyrfalcon - (species)	Falco rusticolus gyrfalcon - (species)	MC1R	Falco rusticolus gyrfalcon - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Malurus leucopterus white-winged fairy-wren - (species)	Intraspecific	Candidate Gene	Doucet SM; Shawkey MD; Rathburn MK ; et al. (2004) Concordant evolution of plumage colour, feather microstructure and a melanocortin receptor gene betw[...]	GP00000610	MC1R Q01726	Morphology	A16T caused by guanine-to-adenine (G_A) transition at site 46; and/or I38N cause by a tyrosine-to-adenine (T_A) transition at site 113; and/or V11N caused by a G_A transition at site 331; and/or Q157R caused by an A_G substitution at site 470; Val166Ileu - exact causing amino acid change(s) unknown	Malurus leucopterus white-winged fairy-wren - (species)	Malurus leucopterus white-winged fairy-wren - (species)	MC1R	Malurus leucopterus white-winged fairy-wren - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Stercorarius parasiticus (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000611	MC1R Q01726	Morphology	R230H	Stercorarius parasiticus (species)	Stercorarius parasiticus (species)	MC1R	Stercorarius parasiticus (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula leucogaster (species)	Intraspecific	Candidate Gene	Baião PC; Parker PG (2012 May-Jun) Evolution of the melanocortin-1 receptor (MC1R) in Boobies and Gannets (Aves, Suliformes).	GP00000612	MC1R Q01726	Morphology	R112H	Sula leucogaster (species)	Sula leucogaster (species)	MC1R	Sula leucogaster (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula sula red-footed booby - (species)	Intraspecific	Candidate Gene	Baião PC; Schreiber E; Parker PG (2007 Jul-Aug) The genetic basis of the plumage polymorphism in red-footed boobies (Sula sula): a melanocortin-1 re[...]	GP00000613	MC1R Q01726	Morphology	V85M and/or H207R; current data cannot determine which one or if both these substitutions are underlying the phenotypic variation	Sula sula red-footed booby - (species)	Sula sula red-footed booby - (species)	MC1R	Sula sula red-footed booby - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Smith R; Healy E; Siddiqui S (1998) Melanocortin 1 receptor variants in an Irish population.	GP00000615	MC1R Q01726	Morphology	R151C	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000616	MC1R Q01726	Morphology	D294H	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000617	MC1R Q01726	Morphology	R160W	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Box NF; Wyeth JR; O'Gorman LE ; et al. (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. 3 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. Harding RM; Healy E; Ray AJ (2000) Evidence for variable selective pressures at MC1R. Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000618	MC1R Q01726	Morphology	Val60Leu	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000619	MC1R Q01726	Morphology	Asp84Glu	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000620	MC1R Q01726	Morphology	Val92Met	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000621	MC1R Q01726	Morphology	Arg142His	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000622	MC1R Q01726	Morphology	Arg151Cys	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000623	MC1R Q01726	Morphology	Ile155Thr	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000624	MC1R Q01726	Morphology	Arg160Trp	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000625	MC1R Q01726	Morphology	Arg163Gln	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000626	MC1R Q01726	Morphology	Asp294His	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Aspidoscelis inornatus Little striped whiptail - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000627	MC1R Q01726	Morphology	I170T	Aspidoscelis inornatus Little striped whiptail - (species)	Aspidoscelis inornatus Little striped whiptail - (species)	MC1R	Aspidoscelis inornatus Little striped whiptail - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Holbrookia maculata lesser earless lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000628	MC1R Q01726	Morphology	V168I; but failed functional validation in Rosenblum et al. 2010	Holbrookia maculata lesser earless lizard - (species)	Holbrookia maculata lesser earless lizard - (species)	MC1R	Holbrookia maculata lesser earless lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Sceloporus undulatus fence lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Römpler H; Schöneberg T ; et al. (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000629	MC1R Q01726	Morphology	H208Y	Sceloporus undulatus fence lizard - (species)	Sceloporus undulatus fence lizard - (species)	MC1R	Sceloporus undulatus fence lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Lalueza-Fox C; Römpler H; Caramelli D ; et al. (2007) A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals.	GP00000630	MC1R Q01726	Morphology	Arg307Gly	Homo sapiens human - (species)	Homo sapiens human - (species)	MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC4R	Feeding behavior	Coding, SNP	Astyanax mexicanus Mexican tetra - (species)	Intraspecific	Linkage Mapping	Aspiras AC; Rohner N; Martineau B ; et al. (2015) Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditio[...]	GP00000637	mc4r B0V1P1	Behavior	Gly145Ser (candidate mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species)	MC4R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC4R	Sexual maturation (onset)	Gene Amplification, Complex Change	Xiphophorus maculatus southern platyfish - (species)	Intraspecific	Linkage Mapping	Lampert KP; Schmidt C; Fischer P ; et al. (2010) Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorph[...]	GP00000638	mc4r B0V1P1	Physiology	unknown in the species used in crosses but a strong coreelation of gene copy number is found with the phenotype in two closely related species	Xiphophorus maculatus southern platyfish - (species)	Xiphophorus maculatus southern platyfish - (species)	MC4R	Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
metallothionein (Mtn)	Metal tolerance	Gene Amplification, Complex Change	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Otto E; Young JE; Maroni G (1986) Structure and expression of a tandem duplication of the Drosophila metallothionein gene. 1 Additional References Maroni G; Wise J; Young JE (1987) Metallothionein gene duplications and metal tolerance in natural populations of Drosophila melanogas[...]	GP00000653	MtnA P04357	Physiology	Gene duplication	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	metallothionein (Mtn)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Mi1.2	Pathogen resistance (parasite)	Unknown, Unknown	Solanum lycopersicum tomato - (species)	Intraspecific	Linkage Mapping	Rossi M; Goggin FL; Milligan SB ; et al. (1998) The nematode resistance gene Mi of tomato confers resistance against the potato aphid. 2 Additional References Seah S; Yaghoobi J; Rossi M (2004) The nematode-resistance gene, Mi-1, is associated with an inverted chromosomal segment in susceptibl[...] Vos P; Simons G; Jesse T (1998) The tomato Mi-1 gene confers resistance to both root-knot nematodes and potato aphids.	GP00000655	Mi-1.2 O81137	Physiology	Not identified	Solanum peruvianum (species)	Solanum lycopersicum tomato - (species)	Mi1.2	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
mir-92a	Trichome pattern (leg)	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Arif S; Murat S; Almudi I ; et al. (2013) Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster.	GP00000661		Morphology	Not identified	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	mir-92a	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Molybdenum transporter1 (MOT1)	Metal tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Baxter I; Muthukumar B; Park HC ; et al. (2008) Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is co[...] 1 Additional References Forsberg SK; Andreatta ME; Huang XY (2015) The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentratio[...]	GP00000676	MOT1 Q9SL95	Physiology	53bp deletion in promoter	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Molybdenum transporter1 (MOT1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Molybdenum transporter1 (MOT1)	Metal tolerance	Gene Amplification, Insertion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Association Mapping	Forsberg SK; Andreatta ME; Huang XY ; et al. (2015) The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentratio[...]	GP00000677	MOT1 Q9SL95	Physiology	330bp duplication followed by minor indels	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Molybdenum transporter1 (MOT1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Leptodactylus ocellatus argus frog - (species) D	Intraspecific	Candidate Gene	Moore DJ; Halliday DC; Rowell DM ; et al. (2009) Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000701	Atp1a1 Q8VDN2	Physiology	2 mutations	Leptodactylus ocellatus argus frog - (species)	Leptodactylus ocellatus argus frog - (species) D	Na/K-ATPase alpha-subunit	Leptodactylus ocellatus argus frog - (species)	Published - Accepted by Curator
nath-10	Fertility (sperm number; egg laying rate)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Duveau F; Félix MA (2012) Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.	GP00000718	nath-10 O01757	Morphology	Met746Ile (according to Table S2 C>T but it should be G>A - Needs curation)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	nath-10	Caenorhabditis elegans (species)	Published - Accepted by Curator
natriuretic peptide precursor type C (NPPC)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Estrada K; Krawczak M; Schreiber S ; et al. (2009) A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide si[...]	GP00000719	Nppc Q61839	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	natriuretic peptide precursor type C (NPPC)	Homo sapiens human - (species)	Published - Accepted by Curator
natriuretic peptide receptor 3 (NPR3)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Estrada K; Krawczak M; Schreiber S ; et al. (2009) A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide si[...] 1 Additional References Soranzo N; Rivadeneira F; Chinappen-Horsley U (2009) Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations wi[...]	GP00000720	NPR3 Q8L746	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	natriuretic peptide receptor 3 (NPR3)	Homo sapiens human - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000730	SCN4A P35499	Physiology	G1566A in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)	SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000731	SCN4A P35499	Physiology	I1561V in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)	SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000732	SCN4A P35499	Physiology	I1556L and/or D1568N and/or G1569V	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)	SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
Nav1.6 sodium channel	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000735	SCN8A Q9UQD0	Physiology	Ile1709Val	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D	Nav1.6 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
Nav1.7 sodium channel	Xenobiotic resistance (TTX)	4 Mutations: Coding SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000736	SCN9A Q15858	Physiology	4 mutations	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D	Nav1.7 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
npr-1	Aggregation behavior Foraging behavior CO2 avoidance Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	de Bono M; Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in[...] 4 Additional References Gloria-Soria A; Azevedo RB (2008) npr-1 Regulates foraging and dispersal strategies in Caenorhabditis elegans. Andersen EC; Bloom JS; Gerke JP (2014) A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth[...] McGrath PT; Rockman MV; Zimmer M (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] Reddy KC; Andersen EC; Kruglyak L (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans.	GP00000739	npr-1 Q18534	Behavior Behavior Behavior Behavior	Val215Phe (pleiotropic; see other entries)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	npr-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000745	Oca2 Q62052	Morphology Physiology	Deletion of exon 21 N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D	Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (eyes; skin)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Eiberg H; Troelsen J; Nielsen M ; et al. (2008) Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory el[...] 3 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...] Visser M; Kayser M; Palstra RJ (2012) HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long[...] Beleza S; Johnson NA; Candille SI (2013) Genetic architecture of skin and eye color in an African-European admixed population.	GP00000747	Oca2 Q62052	Morphology	Causative SNP in enhancer localized in intron of neighbor gene	Homo sapiens human - (species)	Homo sapiens human - (species)	Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
Oca2	Coloration (skin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Edwards M; Bigham A; Tan J ; et al. (2010) Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: furth[...] 1 Additional References Yang Z; Zhong H; Chen J (2016) A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution.	GP00000748	Oca2 Q62052	Morphology	His615Arg	Homo sapiens human - (species)	Homo sapiens human - (species) D	Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	Coding, SNP	Neochromis greenwoodi (species)	Intraspecific	Candidate Gene	Terai Y; Seehausen O; Sasaki T ; et al. (2006) Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids.	GP00000776	OPN1LW P04000	Physiology	Candidate mutations are CS180A and/or I277C (human LWS/MWS numbering)	African cichlids (no rank)	Neochromis greenwoodi (species)	opsin - rhodopsin (LWS)	Neochromis greenwoodi (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	3 Mutations: Coding SNP	Pundamilia pundamilia (species)	Intraspecific	Candidate Gene	Seehausen O; Terai Y; Magalhaes IS ; et al. (2008) Speciation through sensory drive in cichlid fish.	GP00000777	OPN1LW P04000	Physiology	3 mutations	Pundamilia pundamilia (species)	Pundamilia pundamilia (species)	opsin - rhodopsin (LWS)	Pundamilia pundamilia (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius pachinus (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000795	Optix Q95RW8	Morphology	Not identified	Heliconius cydno (species)	Heliconius pachinus (species)	Optix	Heliconius pachinus (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius himera (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000796	Optix Q95RW8	Morphology	Not identified	Heliconius erato crimson-patched longwing - (species)	Heliconius himera (species)	Optix	Heliconius himera (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius erato crimson-patched longwing - (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000797	Optix Q95RW8	Morphology	Not identified	Heliconius erato crimson-patched longwing - (species)	Heliconius erato crimson-patched longwing - (species)	Optix	Heliconius erato crimson-patched longwing - (species)	Published - Accepted by Curator
Optix	Coloration (wing, Mullerian mimicry)	Cis-regulatory, Unknown	Heliconius melpomene postman butterfly - (species)	Intraspecific	Linkage Mapping	Reed RD; Papa R; Martin A ; et al. (2011) optix drives the repeated convergent evolution of butterfly wing pattern mimicry. 1 Additional References Hines HM; Counterman BA; Papa R (2011) Wing patterning gene redefines the mimetic history of Heliconius butterflies.	GP00000798	Optix Q95RW8	Morphology	Not identified	Heliconius melpomene postman butterfly - (species)	Heliconius melpomene postman butterfly - (species)	Optix	Heliconius melpomene postman butterfly - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000799	OR7D4 Q8NG98	Physiology	P79L	Homo sapiens human - (species)	Homo sapiens human - (species)	OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000800	OR7D4 Q8NG98	Physiology	R227G	Homo sapiens human - (species)	Homo sapiens human - (species)	OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000801	OR7D4 Q8NG98	Physiology	T133M	Homo sapiens human - (species)	Homo sapiens human - (species)	OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000802	OR7D4 Q8NG98	Physiology	S84N	Homo sapiens human - (species)	Homo sapiens human - (species)	OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
Overdrive	Hybrid incompatibility (male F1 sterility)	Coding, SNP	Drosophila pseudoobscura (species)	Intraspecific	Linkage Mapping	Phadnis N; Orr HA (2009) A single gene causes both male sterility and segregation distortion in Drosophila hybrids.	GP00000816	Ovd Q2LZF7	Physiology	6 candidate non-synonymous changes - the effect of single amino acid changes has not been tested	Drosophila pseudoobscura (species)	Drosophila pseudoobscura (species)	Overdrive	Drosophila pseudoobscura (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00000817	LPAR6 P43657	Morphology	at position 69 insertion of 4bp CATG - causes frameshift at codon 24 (PTC +29) N	Homo sapiens human - (species)	Homo sapiens human - (species) D	P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	2 mutations	Anopheles sinensis (species)	Anopheles sinensis (species) D	para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 1 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D	para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D	para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Franck P; Siegwart M; Olivares J ; et al. (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D	para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Linkage Mapping	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Linkage Mapping	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 2 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] Park Y; Taylor MF (1997) A novel mutation L1029H in sodium channel gene hscp associated with pyrethroid resistance for Heliot[...]	GP00000833	para P35500	Physiology	L1029H (=position L1014)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]	GP00000839	para P35500	Physiology	L925I	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]	GP00000840	para P35500	Physiology	M918L	Hyalella azteca (species)	Hyalella azteca (species) D	para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.	GP00000841	para P35500	Physiology	L1014H	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Vais H; Williamson MS; Devonshire AL ; et al. (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. 1 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000846	para P35500	Physiology	T929I (ACC to ATC or ATA)	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D	para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000848	para P35500	Physiology	L1014F	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)	para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D	para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
pastrel	Pathogen resistance (viruses)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Magwire MM; Fabian DK; Schweyen H ; et al. (2012) Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving [...]	GP00000854	pst Q8IQ82	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	pastrel	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Patched1 (Ptc1)	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lettre G (2011) Recent progress in the study of the genetics of height.	GP00000855	ptch1 Q98864	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	Patched1 (Ptc1)	Homo sapiens human - (species)	Published - Accepted by Curator
PGRP-LC	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sackton TB; Lazzaro BP; Clark AG (2010) Genotype and gene expression associations with immune function in Drosophila.	GP00000861	PGRP-LC Q9GNK5	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	PGRP-LC	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
phytochrome A (PHYA)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Maloof JN; Borevitz JO; Dabi T ; et al. (2001) Natural variation in light sensitivity of Arabidopsis.	GP00000870	PHYA P14712	Physiology	M548T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	phytochrome A (PHYA)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome B (PHYB)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Filiault DL; Wessinger CA; Dinneny JR ; et al. (2008) Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.	GP00000871	PHYB P14713	Physiology	I143L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	phytochrome B (PHYB)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome C (PHYC)	Light sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006) The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]	GP00000873	PHYC P14714	Physiology	K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	phytochrome C (PHYC)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome D (PHYD)	Leaf morphology (increased petiole length) Cotyledon morphology (reduced cotyledon area) Coloration (anthocyanin accumulation in seedling stems) Plant size (diminished effect of end-of-day pulse of far red light on hypocotyl elongation) Plant architecture (decrease in number of rosette leaves at onset of flowering)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Aukerman MJ; Hirschfeld M; Wester L ; et al. (1997) A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome [...]	GP00000874	PHYD P42497	Morphology Morphology Morphology Physiology Morphology	14bp deletion causing premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	phytochrome D (PHYD)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000886	Pitx1 P70314	Morphology	488bp promoter region : deletion 1 ; 5 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000887	Pitx1 P70314	Morphology	488bp promoter region : deletion 2 ; 757bp deletion present in the pelvic-reduced BEPA population from Alaska	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000888	Pitx1 P70314	Morphology	488bp promoter region : deletion 3 ; 3.5 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000889	Pitx1 P70314	Morphology	488bp promoter region : deletion 4 ; 757 bp deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000890	Pitx1 P70314	Morphology	488bp promoter region : deletion 5 ; 2 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000891	Pitx1 P70314	Morphology	488bp promoter region : deletion 6 ; 973bp deletion present in the Hump Lake AK pelvic-reduced population (HUMP)	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000892	Pitx1 P70314	Morphology	488bp promoter region : deletion 7 ; 1868bp deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000893	Pitx1 P70314	Morphology	488bp promoter region : deletion 8 ; 8 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
pitx1	Pelvis morphology (loss of ventral spines)	Cis-regulatory, Deletion	Gasterosteus aculeatus three-spined stickleback - (species) D	Intraspecific	Linkage Mapping	Shapiro MD; Marks ME; Peichel CL ; et al. (2004) Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. 1 Additional References Chan YF; Marks ME; Jones FC (2010) Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.	GP00000894	Pitx1 P70314	Morphology	488bp promoter region : deletion 9 ; 8 kb deletion	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species) D	pitx1	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
plep-1	Male-male copulatory behavior	Coding, SNP	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Noble LM; Chang AS; McNelis D ; et al. (2015) Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.	GP00000897	plep-1 A0A0K3AR66	Behavior	V278D	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	plep-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
plg-1	Copulatory plug	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Palopoli MF; Rockman MV; TinMaung A ; et al. (2008) Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.	GP00000898		Physiology	insertion of transposable element in an exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	plg-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
poils au dos (pad)	Bristle number (thorax)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Gibert JM; Marcellini S; David JR ; et al. (2005) A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription [...]	GP00000915	pad Q9VEW6	Morphology	29bp deletion N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	poils au dos (pad)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
PPAR-alpha	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 1 Additional References Bigham A; Bauchet M; Pinto D (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...]	GP00000917	PPARA Q07869	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	PPAR-alpha	Homo sapiens human - (species)	Published - Accepted by Curator
PPAR-delta	Body size (height)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	N'Diaye A; Chen GK; Palmer CD ; et al. (2011) Identification, replication, and fine-mapping of Loci associated with adult height in individuals of[...] 1 Additional References Lango Allen H; Estrada K; Lettre G (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height.	GP00000918	PPARD Q03181	Morphology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	PPAR-delta	Homo sapiens human - (species)	Published - Accepted by Curator
ppw-1	Resistance to dsRNA	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Tijsterman M; Okihara KL; Thijssen K ; et al. (2002) PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]	GP00000921		Physiology	1bp deletion resulting in stop codon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	ppw-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Prdm9	Hybrid incompatibility (F1 male sterility) Recombination rate (use of recombination hotspots)	Unknown, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Mihola O; Trachtulec Z; Vlcek C ; et al. (2009) A mouse speciation gene encodes a meiotic histone H3 methyltransferase. 2 Additional References Baudat F; Buard J; Grey C (2010) PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Flachs P; Mihola O; Simeček P (2012) Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.	GP00000922	Prdm9 Q96EQ9	Physiology Physiology	possible dosage difference (number of gene copies) interacting with an allele that affects post-transcriptional stability	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Prdm9	Mus musculus house mouse - (species)	Published - Accepted by Curator
Prdm9	Recombination rate (use of recombination hotspots)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Berg IL; Neumann R; Sarbajna S ; et al. (2011) Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots [...]	GP00000923	Prdm9 Q96EQ9	Physiology	Various haplotypes	Homo sapiens human - (species)	Homo sapiens human - (species)	Prdm9	Homo sapiens human - (species)	Published - Accepted by Curator
protoporphyrinogen oxidase (PPO2 = PPX2L)	Xenobiotic resistance (herbicides)	Coding, Deletion	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt WL; Hager AG; McCormick JS ; et al. (2006) A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase.	GP00000929	PPX2L Q0NZW6	Physiology	3bp deletion; deletion of G210	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D	protoporphyrinogen oxidase (PPO2 = PPX2L)	Amaranthus tuberculatus (species)	Published - Accepted by Curator
R2R3-Myb	Coloration (flowers)	Cis-regulatory, Unknown	Phlox drummondii (species)	Intraspecific	Linkage Mapping	Hopkins R; Rausher MD (2011) Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii.	GP00000948	H8ZS70	Morphology	unknown	Phlox drummondii (species)	Phlox drummondii (species)	R2R3-Myb	Phlox drummondii (species)	Published - Accepted by Curator
RAC1	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Borhan MH; Holub EB; Beynon JL ; et al. (2004) The arabidopsis TIR-NB-LRR gene RAC1 confers resistance to Albugo candida (white rust) and is depend[...]	GP00000949	ARAC3 Q38912	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RAC1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RAS1	Salt tolerance Abscisic acid sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ren Z; Zheng Z; Chinnusamy V ; et al. (2010) RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis.	GP00000953	RAS1 O04515	Physiology Physiology	Premature stop codon; Lys>STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RAS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RCR3	Pathogen resistance	Coding, SNP	Solanum peruvianum (species)	Intraspecific	Candidate Gene	Hörger AC; Ilyas M; Stephan W ; et al. (2012) Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathog[...]	GP00000963	Rcr3 Q8S333	Physiology	Candidate amino acid changes are I206K and/or Q222E and/or S330A	Solanum peruvianum (species)	Solanum peruvianum (species)	RCR3	Solanum peruvianum (species)	Published - Accepted by Curator
Regulator of G-protein signaling 2 (RGS2)	Anxiety	Unknown, Unknown	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Yalcin B; Willis-Owen SA; Fullerton J ; et al. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mic[...]	GP00000967	Rgs2 O08849	Behavior	unknown	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	Regulator of G-protein signaling 2 (RGS2)	Mus musculus house mouse - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Thompson M; Shotkoski F; ffrench-Constant R (1993) Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]	GP00000968	Rdl P25123	Physiology	Ala302Ser	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	resistance to dieldrin	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species) D	Intraspecific	Candidate Gene	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000969	Rdl P25123	Physiology	Ala302Ser	Anopheles arabiensis (species)	Anopheles arabiensis (species) D	resistance to dieldrin	Anopheles arabiensis (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000970	Rdl P25123	Physiology	Ala302Gly	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	resistance to dieldrin	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Alon M; Alon F; Nauen R ; et al. (2008) Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associat[...]	GP00000971	Rdl P25123	Physiology	Ala302Ser	Bemisia tabaci (species)	Bemisia tabaci (species) D	resistance to dieldrin	Bemisia tabaci (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Kaku K; Matsumura F (1994) Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]	GP00000972	Rdl P25123	Physiology	Ala302Ser	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D	resistance to dieldrin	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]	GP00000973	Rdl P25123	Physiology	Ala302Ser	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D	resistance to dieldrin	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993) A point mutation in a Drosophila GABA receptor confers insecticide resistance. 2 Additional References Lee HJ; Rocheleau T; Zhang HG (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000974	Rdl P25123	Physiology	Ala302Ser	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species)	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Xmrk-2 Q91389	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species)	resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Hypothenemus hampei coffee berry borer - (species) D	Intraspecific	Candidate Gene	Brun LO; Stuart J; Gaudichon V ; et al. (1995) Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...]	GP00000977	Rdl P25123	Physiology	Ala302Ser	Hypothenemus hampei coffee berry borer - (species)	Hypothenemus hampei coffee berry borer - (species) D	resistance to dieldrin	Hypothenemus hampei coffee berry borer - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000978	Rdl P25123	Physiology	Ala302Ser	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	resistance to dieldrin	Musca domestica house fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anthony N; Unruh T; Ganser D ; et al. (1998) Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.	GP00000979	Rdl P25123	Physiology	Ala302Gly	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	resistance to dieldrin	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Periplaneta americana American cockroach - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000980	Rdl P25123	Physiology	Ala302Ser	Periplaneta americana American cockroach - (species)	Periplaneta americana American cockroach - (species) D	resistance to dieldrin	Periplaneta americana American cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Tribolium castaneum red flour beetle - (species)	Intraspecific	Candidate Gene	Miyazaki M; Matsumura F; Beeman RW (1995) DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...] 1 Additional References Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000981	Rdl P25123	Physiology	Ala302Ser	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species)	resistance to dieldrin	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
resistant to methyl viologen 1 (RMV1)	Polyamine uptake	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Fujita M; Fujita Y; Iuchi S ; et al. (2012) Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis.	GP00000982	RMV1 Q9FFL1	Physiology	Ile377Phe N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	resistant to methyl viologen 1 (RMV1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Rhg1	Pathogen resistance (cyst nematode)	Gene Amplification, Complex Change	Glycine max soybean - (species)	Intraspecific	Linkage Mapping	Cook DE; Lee TG; Guo X ; et al. (2012) Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean.	GP00000985	rhg1s Q8L3Y5	Physiology	Copy number Variant : 10-tandem copies of the gene cluster in resistant strains ; the 3 dissimilar genes participate to resistance	Glycine max soybean - (species)	Glycine max soybean - (species)	Rhg1	Glycine max soybean - (species)	Published - Accepted by Curator
RHO2	Temperature tolerance / virulence	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000986	RHO2 P06781	Physiology	3'UTR polymorphism	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	RHO2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RLM1	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Staal J; Kaliff M; Bohman S ; et al. (2006) Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]	GP00000991	RLM1A F4I594	Physiology	Digenic; deletion of gene1 and premature stop codons in gene2 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RLM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RLM2 cluster	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Staal J; Kaliff M; Bohman S ; et al. (2006) Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]	GP00000992	RLM1B Q9CAK1	Physiology	the locus contains two paralogues; one of which is deleted and the other pseudogenized in Ler-0 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RLM2 cluster	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RLM3	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Staal J; Kaliff M; Dewaele E ; et al. (2008) RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fun[...]	GP00000993	RLM3 Q9FT77	Physiology	gene deletion N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RLM3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RME1 [possible pseudo-replicate of laboratory strain entry]	Sporulation efficiency	Cis-regulatory, Deletion	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00000995	RME1 P32338	Physiology	single nucleotide deletion in promoter region	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	RME1 [possible pseudo-replicate of laboratory strain entry]	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ROSEA	Coloration (flowers)	Unknown, Unknown	Antirrhinum majus snapdragon - (species)	Intraspecific	Linkage Mapping	Whibley AC; Langlade NB; Andalo C ; et al. (2006) Evolutionary paths underlying flower color variation in Antirrhinum.	GP00000997	ROS1 Q2VAZ7	Morphology	Not identified	Antirrhinum majus snapdragon - (species)	Antirrhinum majus snapdragon - (species)	ROSEA	Antirrhinum majus snapdragon - (species)	Published - Accepted by Curator
RPM1	Pathogen resistance	Gene Loss, Indel N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Grant MR; McDowell JM; Sharpe AG ; et al. (1998) Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis. 2 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Stahl EA; Dwyer G; Mauricio R (1999) Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis.	GP00001000	RPM1 Q39214	Physiology	3.7kb indel with a null-state in the sensitive strains N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPM1	Pathogen resistance	Gene Loss, Complex Change N	Brassica napus rape - (species)	Intraspecific	Linkage Mapping	Grant MR; McDowell JM; Sharpe AG ; et al. (1998) Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis.	GP00001001	RPM1 Q39214	Physiology	deletion N	Brassica napus rape - (species)	Brassica napus rape - (species)	RPM1	Brassica napus rape - (species)	Published - Accepted by Curator
RPP1-WsA	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001002	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP1-WsA	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsB	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001003	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP1-WsB	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsC	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001004	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP1-WsC	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP2A-RPP2B	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sinapidou E; Williams K; Nott L ; et al. (2004) Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in A[...]	GP00001006	RPP2A P51407	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP2A-RPP2B	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP4	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	van der Biezen EA; Freddie CT; Kahn K ; et al. (2002) Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]	GP00001007	RPP4 F4JNA9	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP5	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	van der Biezen EA; Freddie CT; Kahn K ; et al. (2002) Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001008	RPP5 F4JNB7	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP5	Pathogen resistance	Gene Amplification, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Parker JE; Coleman MJ; Szabò V ; et al. (1997) The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 re[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001009	RPP5 F4JNB7	Physiology	Partial duplication sufficient to increase resistance	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP8	Pathogen resistance	Coding, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	McDowell JM; Dhandaydham M; Long TA ; et al. (1998) Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resi[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001010	RPP8 Q8W4J9	Physiology	Chimeric fusion of two paralogues followed by coding divergence	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPP8	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Mindrinos M; Katagiri F; Yu GL ; et al. (1994) The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site [...]	GP00001011	RPS2 Q42484	Physiology	10bp insertion close to the 5' end causing a frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Caicedo AL; Schaal BA; Kunkel BN (1999) Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.	GP00001012	RPS2 Q42484	Physiology	W235* due to G704A N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS4	Pathogen resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Narusaka M; Shirasu K; Noutoshi Y (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.	GP00001013	RPS4 Q9XGM3	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	RPS4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS5	Pathogen resistance	Gene Loss, Complex Change N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Henk AD; Warren RF; Innes RW (1999) A new Ac-like transposon of Arabidopsis is associated with a deletion of the RPS5 disease resistance[...] 1 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.	GP00001014	RPS5 O64973	Physiology	Deletion N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RPS5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RRS1	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Birker D; Heidrich K; Takahara H (2009) A locus conferring resistance to Colletotrichum higginsianum is shared by four geographically distin[...]	GP00001015	RRS1 P0DKH5	Physiology	Premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	RRS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RSF1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00001016	HFR1 Q9FE22	Physiology	D181G	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	RSF1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SBNO1	Head size	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Taal HR; Pourcain BS; Thiering E ; et al. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference.	GP00001023	SBNO1 A3KN83	Morphology	Ser729Asn	Homo sapiens human - (species)	Homo sapiens human - (species)	SBNO1	Homo sapiens human - (species)	Published - Accepted by Curator
scabrous	Bristle number (abdomen)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Lai C; Lyman RF; Long AD ; et al. (1994) Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Droso[...]	GP00001024	sca P21520	Morphology	unknown; but different sites than for thorax association	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	scabrous	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
scabrous	Bristle number (thorax)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Lai C; Lyman RF; Long AD ; et al. (1994) Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Droso[...]	GP00001025	sca P21520	Morphology	unknown; but different sites than for abdomen association	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	scabrous	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
scd-2	Diapause	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Reiner DJ; Ailion M; Thomas JH ; et al. (2008) C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]	GP00001026	scd-2 O76411	Physiology	Gly985Arg	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)	scd-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
SG3/At4g30720	Growth (shoots)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Vlad D; Rappaport F; Simon M ; et al. (2010) Gene transposition causing natural variation for growth in Arabidopsis thaliana.	GP00001036	PDE327 F4JQE2	Physiology	Premature stop codon at the SG3 locus in Bur-0 (a 1bp deletion in exon four of At4g30720 results in a frame shift; predicting a premature stop codon which terminates the ORF after 5 amino acids); but in this accession this gene has a functional copy at a N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	SG3/At4g30720	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SIR2	Longevity	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00001054	SIR2 P06700	Physiology	1 to 5 amino-acid substitutions	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	SIR2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SLC24A5 (NCKX5)	Coloration (eyes; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lamason RL; Mohideen MA; Mest JR ; et al. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. 5 Additional References Beleza S; Johnson NA; Candille SI (2013) Genetic architecture of skin and eye color in an African-European admixed population. Wakamatsu K; Kavanagh R; Kadekaro AL (2006) Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as[...] Ginger RS; Askew SE; Ogborne RM (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activ[...] Quillen EE; Bauchet M; Bigham AW (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...] Basu Mallick C; Iliescu FM; Möls M (2013) The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.	GP00001056	Slc24a5 Q8C261	Morphology	Ala111Thr	Homo sapiens human - (species)	Homo sapiens human - (species)	SLC24A5 (NCKX5)	Homo sapiens human - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (eyes; coat)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Candidate Gene	Mariat D; Taourit S; Guérin G (2003 Jan-Feb) A mutation in the MATP gene causes the cream coat colour in the horse.	GP00001057	SLC45A2 Q9UMX9	Morphology	N153D	Equus caballus horse - (species)	Equus caballus horse - (species)	SLC45A2=MATP	Equus caballus horse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (eyes; hair; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Graf J; Hodgson R; van Daal A (2005) Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation varia[...] 3 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...] Quillen EE; Bauchet M; Bigham AW (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...] Cook AL; Chen W; Thurber AE (2009) Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5[...]	GP00001061	SLC45A2 Q9UMX9	Morphology	Phe374Leu	Homo sapiens human - (species)	Homo sapiens human - (species)	SLC45A2=MATP	Homo sapiens human - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (fur)	Coding, SNP	Panthera tigris tiger - (species)	Intraspecific	Association Mapping	Xu X; Dong GX; Hu XS ; et al. (2013) The genetic basis of white tigers.	GP00001063	SLC45A2 Q9UMX9	Morphology	A477V	Panthera tigris tiger - (species)	Panthera tigris tiger - (species)	SLC45A2=MATP	Panthera tigris tiger - (species)	Published - Accepted by Curator
slowpoke (slo)	Courtship song (sine song frequency)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Ding Y; Berrocal A; Morita T ; et al. (2016) Natural courtship song variation caused by an intronic retroelement in an ion channel gene.	GP00001066	slo Q03720	Behavior	6.7kb "Shelder" retroelement insertion in slowpoke intron; with effect on splicing	Drosophila simulans (species)	Drosophila simulans (species) D	slowpoke (slo)	Drosophila simulans (species)	Published - Accepted by Curator
SR-CII	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00001071	Sr-CII Q5ELW9	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	SR-CII	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
SRF3	Hybrid Incompatibility	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Alcázar R; García AV; Kronholm I ; et al. (2010) Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...] 1 Additional References Alcázar R; von Reth M; Bautor J (2014) Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]	GP00001072	SRF3 Q6R2K3	Physiology	Complex haplotype	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	SRF3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SRF3	Hybrid Incompatibility	Unknown, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Alcázar R; García AV; Kronholm I ; et al. (2010) Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...] 1 Additional References Alcázar R; von Reth M; Bautor J (2014) Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]	GP00001073	SRF3 Q6R2K3	Physiology	Complex haplotype	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	SRF3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SVP (SHORT VEGETATIVE PHASE)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Méndez-Vigo B; Martínez-Zapater JM; Alonso-Blanco C (2013) The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic [...]	GP00001087	SVP Q9FVC1	Physiology	Ala32Val	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	SVP (SHORT VEGETATIVE PHASE)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Linkage Mapping	Coste A; Turner V; Ischer F ; et al. (2006) A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of hetero[...]	GP00001090	TAC1 A7IZW4	Physiology	N977D	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Gene Amplification, Complex Change	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001091	TAC1 A7IZW4	Physiology	Copy number Variant	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Coding, Deletion	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001092	TAC1 A7IZW4	Physiology	1a.a. deletion	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Coding, Deletion	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001093	TAC1 A7IZW4	Physiology	7a.a. deletion	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001094	TAC1 A7IZW4	Physiology	G980E	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001095	TAC1 A7IZW4	Physiology	A736V	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001096	TAC1 A7IZW4	Physiology	T225A	Candida albicans (species)	Candida albicans (species) D	TAC1	Candida albicans (species)	Published - Accepted by Curator
tan	Coloration (abdomen; female)	Cis-regulatory, Unknown	Drosophila erecta (species) D	Intraspecific	Linkage Mapping	Yassin A; Bastide H; Chung H ; et al. (2016) Ancient balancing selection at tan underlies female colour dimorphism in Drosophila erecta.	GP00001097	t Q9W369	Morphology	exact causing mutation(s) unknown - the t_MSE enhancer from the dark allele drives higher levels of GFP expression in D. melanogaster than from the light allele	Drosophila erecta (species)	Drosophila erecta (species) D	tan	Drosophila erecta (species)	Published - Accepted by Curator
tan	Coloration (abdomen)	Cis-regulatory, Unknown	Drosophila novamexicana (species) D	Intraspecific	Linkage Mapping	Wittkopp PJ; Stewart EE; Arnold LL ; et al. (2009) Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.	GP00001098	t Q9W369	Morphology	2.7kb non-coding interval; 13 SNPs + 2 indels differing between species	Drosophila americana (species)	Drosophila novamexicana (species) D	tan	Drosophila novamexicana (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, Insertion N	Acinonyx jubatus cheetah - (species) D	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001105	Lvrn Q2KHK3	Morphology	1bp insertion resulting in frameshift N	Acinonyx jubatus cheetah - (species)	Acinonyx jubatus cheetah - (species) D	Taqpep	Acinonyx jubatus cheetah - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001106	Lvrn Q2KHK3	Morphology	A/T139N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species)	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001107	Lvrn Q2KHK3	Morphology	S59stop N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species)	Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species)	Intraspecific	Linkage Mapping	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001108	Lvrn Q2KHK3	Morphology	W841stop N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species)	Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
TAS1R3	Taste sensitivity (sugar)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Max M; Shanker YG; Huang L ; et al. (2001) Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. 1 Additional References Montmayeur JP; Liberles SD; Matsunami H (2001) A candidate taste receptor gene near a sweet taste locus.	GP00001110	TAS1R3 Q7RTX0	Physiology	I60T; is predicted to introduce a novel N-linked glycosylation site which might interfere with receptor dimerization	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	TAS1R3	Mus musculus house mouse - (species)	Published - Accepted by Curator
TAS2R38	Taste sensitivity (bitter)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kim UK; Jorgenson E; Coon H ; et al. (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthioc[...] 1 Additional References Wooding S; Bufe B; Grassi C (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees.	GP00001111	TAS2R38 P59533	Physiology	P49A and/or A262V and/or V296I	Homo sapiens human - (species)	Homo sapiens human - (species)	TAS2R38	Homo sapiens human - (species)	Published - Accepted by Curator
TAS2R38	Taste sensitivity (bitter)	Coding, SNP	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Wooding S; Bufe B; Grassi C ; et al. (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees.	GP00001112	TAS2R38 P59533	Physiology	M1R; eliminates start codon; protein initiates at later Met. Protein apparently null for signalling	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)	TAS2R38	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
TBX15	Ear shape	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Adhikari K; Reales G; Smith AJ ; et al. (2015) A genome-wide association study identifies multiple loci for variation in human ear morphology.	GP00001113	TBX15 Q96SF7	Morphology	Tbx15 enhancer variation including rs17023457 T or C alleles that affect CART1 binding on a conserved site	Homo sapiens human - (species)	Homo sapiens human - (species)	TBX15	Homo sapiens human - (species)	Published - Accepted by Curator
Tehao	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00001115	Tehao Q9VJX9	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Tehao	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
TFL1/FvTFL1	Flowering time Seasonal growth	Cis-regulatory, Unknown	Fragaria vesca wild strawberry - (species)	Intraspecific	Linkage Mapping	Koskela EA; Mouhu K; Albani MC ; et al. (2012) Mutation in TERMINAL FLOWER1 reverses the photoperiodic requirement for flowering in the wild strawb[...]	GP00001120	TFL1 P93003	Physiology Physiology	unknown	Fragaria vesca wild strawberry - (species)	Fragaria vesca wild strawberry - (species)	TFL1/FvTFL1	Fragaria vesca wild strawberry - (species)	Published - Accepted by Curator
thioester-containing protein 1	Pathogen resistance (Plasmodium; malaria parasite)	Coding, Unknown	Anopheles coluzzii (species)	Intraspecific	Linkage Mapping	Blandin SA; Wang-Sattler R; Lamacchia M ; et al. (2009) Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. 1 Additional References White BJ; Lawniczak MK; Cheng C (2011) Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodiu[...]	GP00001125	TEP-I Q9GYW4	Physiology	coding change - exact causing mutation(s) unknown	Anopheles gambiae African malaria mosquito - (species)	Anopheles coluzzii (species)