Gephebase

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Main Curator	Edit Gene-GePhe	Taxon B	Status	Validator Comment	Date of Sent Email
ABCA1	Coloration (feathers) Cholesterol metabolism	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Attie AD; Hamon Y; Brooks-Wilson AR ; et al. (2002) Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of t[...]	GP00001682	Abca1 P41233	Morphology; Physiology Morphology; Physiology	amino acid substitution at a residue that is conserved in the ABCA1 gene between human; mouse; chicken; and Takifugu rubripes. Generation of a mouse ABCA1 protein with the mutation disrupts protein function. N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		ABCA1	Gallus gallus chicken - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Indel N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000002	ABCA2 A0A0S0G7V0	Physiology	65bp indel in exon16 inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000003	ABCA2 A0A0S0G7V0	Physiology	5bp deletion inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000004	ABCA2 A0A0S0G7V0	Physiology	5bp (GAATA) nucleotide duplication inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002054	ABCA2 A0A0S0G7V0	Physiology	insertion of a transposon Tntransib (2581 bp) in ABCA2 which changes splicing sites in the transcript and lead to an indel in the coding region: change of 1551VETLAHALGFLRHLDKR1567 into 1551AHWGK- LYGSNTQN1563 N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D		ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00002056	ABCA2 A0A0S0G7V0	Physiology	14bp deletion resulting in missense mutations. N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D		ABCA2	Helicoverpa punctigera (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Candidate Gene	Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018) ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]	GP00002057	ABCA2 A0A0S0G7V0	Physiology	loss of exon 6 caused by alternative splicing N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		ABCA2	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002467	ABCA2 Q9BZC7	Physiology	insertion of a 2581-bp transposon Tntransib in ABCA2. This insertion disrupts splicing sites and leads to indels in the protein sequence. CRISPR ABCA2 mutants are highly resistant to Cry2Ab. N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D		ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCB1	Plant size (dwarfism)	Coding, Insertion N	Sorghum bicolor sorghum - (species)	Domesticated	Candidate Gene	Multani DS; Briggs SP; Chamberlin MA ; et al. (2003) Loss of an MDR transporter in compact stalks of maize br2 and sorghum dw3 mutants.	GP00000007	ABCB1 Q9ZR72	Morphology	882bp direct duplication in exon 5 of the dw3 allele driving loss-of-function N	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)		ABCB1	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
ABCB1	Xenobiotic resistance (insecticide; Bt Cry3Aa toxin)	Coding, Deletion N	Chrysomela tremula (species) D	Intraspecific	Candidate Gene	Pauchet Y; Bretschneider A; Augustin S ; et al. (2016) A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle[...]	GP00002466	ABCB1 P08183	Physiology	a four-base-pair deletion at position 1561 introducing a frame shift with a premature stop codon leading to loss of the TpM1 transporter motif as well as the complete second transmembrane domain N	Chrysomela tremula (species)	Chrysomela tremula (species) D		ABCB1	Chrysomela tremula (species)	Published - Accepted by Curator
Abcb4	Biliary Phospholipid Level (low)	Coding, Unknown N	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000008	Abcb4 P21440	Physiology	pseudogenization N	Mammalia mammals - (class)	Cavia porcellus domestic guinea pig - (species)		Abcb4	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
Abcb4	Biliary Phospholipid Level (low)	Coding, Unknown N	Equus caballus horse - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000009	Abcb4 P21440	Physiology	pseudogenization N	Mammalia mammals - (class)	Equus caballus horse - (species)		Abcb4	Equus caballus horse - (species)	Published - Accepted by Curator
ABCC11	Apocrine secretion (ear wax type ; axillary odor)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Yoshiura K; Kinoshita A; Ishida T ; et al. (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. 1 Additional References Martin A; Saathoff M; Kuhn F (2010) A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.	GP00000010	ABCC11 Q96J66	Physiology	1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette	Homo sapiens human - (species)	Homo sapiens human - (species)		ABCC11	Homo sapiens human - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Insertion	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Atsumi S; Miyamoto K; Yamamoto K ; et al. (2012) Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin[...]	GP00000011	ABCC2 A0A0E3ZDK3	Physiology	1a.a. insertion at codon 234 (Tyr)	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D		ABCC2	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Deletion N	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014) ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]	GP00001439		Physiology	About 500 nt genomic deletion over 2 exons involving 246 nt coding 82aa N	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		ABCC2	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Banerjee R; Hasler J; Meagher R ; et al. (2017) Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm[...] 1 Additional References Flagel L; Lee YW; Wanjugi H (2018) Mutational disruption of the ABCC2 gene in fall armyworm, Spodoptera frugiperda, confers resistance [...]	GP00002461	MRP1 H8YF43	Physiology	A nine-base deletion (position 39–47) and a two-base insertion (GC at position 2218) lead to a frameshift and the occurrence of a premature stop codon. The truncated protein is 746 amino acids whereas the ABCC2 of the susceptible strain encodes a protein of 1349 amino acids. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D		ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Boaventura D; Ulrich J; Lueke B ; et al. (2020) Molecular characterization of Cry1F resistance in fall armyworm, Spodoptera frugiperda from Brazil.	GP00002462	MRP1 H8YF43	Physiology	two mutations in the extracellular loop 4 (ECL4) of ABCC2: a deletion of two amino acids (GY) at positions 788 and 789 and the change of a proline to either lysine or arginine at position 799. Expression of mutated ABCC2 in insect cells confirmed the role of these mutations in toxin binding. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D		ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABCG2	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Cohen-Zinder M; Seroussi E; Larkin DM ; et al. (2005) Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chr[...] 1 Additional References Olsen HG; Nilsen H; Hayes B (2007) Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of [...]	GP00000015	Abcg2 Q7TMS5	Physiology	Tyr581Ser	Bos taurus cattle - (species)	Bos taurus cattle - (species)		ABCG2	Bos taurus cattle - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000017	ABO P16442	Physiology	Gly268 (group A) <-> Ala (group B)	Homininae (subfamily)	Homininae (subfamily)		ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000018	ABO P16442	Physiology	Leu266 (group A) <-> Met (group B)	Homininae (subfamily)	Homininae (subfamily)		ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Calafell F; Roubinet F; Ramírez-Soriano A (2008) Evolutionary dynamics of the human ABO gene.	GP00000019	ABO P16442	Physiology	1bp deletion (258G) resulting in frameshift N	Homo sapiens human - (species)	Homo sapiens human - (species) D		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993) Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000020	ABO P16442	Physiology	Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function) two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.	Homo sapiens human - (species)	Homo sapiens human - (species)		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000021	ABO P16442	Physiology	1bp insertion resulting in premature stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species) D		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000022	ABO P16442	Physiology	1bp change resulting in stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species)		ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000023	ABO P16442	Physiology	Uncertain; possibly 9bp deletion resultin in 3a.a. deletion	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)		ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ACD6 = ACCELERATED CELL DEATH 6	Plant size Pathogen resistance (plant microbes) Herbivore resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Todesco M; Balasubramanian S; Hu TT ; et al. (2010) Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana. 1 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.	GP00000025	ACD6 Q8LPS2	Physiology Physiology Physiology	Various	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ACD6 = ACCELERATED CELL DEATH 6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; cyclic ketoenol)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Lueke B; Douris V; Hopkinson JE ; et al. (2020) Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated[...] 1 Additional References Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002513	ACC Q7JV23	Physiology	A2083V	Bemisia tabaci (species)	Bemisia tabaci (species) D		acetyl-CoA carboxylase (ACC)	Bemisia tabaci (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spiromesifen)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species) D	Intraspecific	Candidate Gene	Karatolos N; Williamson MS; Denholm I ; et al. (2012) Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid repla[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002556	ACC Q7JV23	Physiology	E645K	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species) D		acetyl-CoA carboxylase (ACC)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]	GP00002616	ACC Q7JV23	Physiology	a single non-synonymous mutation (gCt > gTt) resulting in an alanine to valine substitution in a highly conserved region of the ACC carboxyltransferase (CT) domain	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		acetyl-CoA carboxylase (ACC)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002617	ACC Q7JV23	Physiology	A1559V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002618	ACC Q7JV23	Physiology	A1847V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D		Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00000030	Ace P07140	Physiology	F331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D		Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D		Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...] 4 Additional References Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Carletto J; Martin T; Vanlerberghe-Masutti F (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii. Benting J; Nauen R (2004) Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates res[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)		Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Nieuwenhuyse P; Demaeght P (2011) Acaricide resistance and resistance mechanisms in Tetranychus urticae populations from rose greenhou[...]	GP00002013	Ace P07140	Physiology	A201S	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Nabeshima T; Kozaki T; Tomita T ; et al. (2003) An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of[...]	GP00002015	Ace P07140	Physiology	Ser431Phe (position 331 in mature Torpedo protein)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		Acetylcholinesterase (Ace-1)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Jiang X; Qu M; Denholm I ; et al. (2009) Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]	GP00002453	Ace P07140	Physiology	an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D		Acetylcholinesterase (Ace-1)	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Lee DW; Choi JY; Kim WT ; et al. (2007) Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.). 3 Additional References Yeh SC; Lin CL; Chang C (2014) Amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos [...] Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Zhang LJ; Jing YP; Li XH (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...]	GP00002454	Ace P07140	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002512	Ace P07140	Physiology	F331W	Bemisia tabaci (species)	Bemisia tabaci (species) D		Acetylcholinesterase (Ace-1)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002571	Ace P07140	Physiology	S119G	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Leeuwen T; Grispou M (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...]	GP00002572	Ace P07140	Physiology	G328A	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Khajehali J; Van Leeuwen T; Grispou M ; et al. (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002573	Ace P07140	Physiology	F331W	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002574	Ace P07140	Physiology	D128E	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Li F; Han Z (2004) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 3 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00002577	Ace P07140	Physiology	A201S	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)		Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Reyes M; Rault M ; et al. (2006) Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002580	Ace P07140	Physiology	F399V = F290V	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D		Acetylcholinesterase (Ace-1)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Hadjivassilis A ; et al. (2007) A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipi[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002581	Ace P07140	Physiology	F290V	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002587	Ace P07140	Physiology	S329(228)P	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D		Acetylcholinesterase (Ace-1)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002589	Ace P07140	Physiology	F330S	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002590	Ace P07140	Physiology	F331H	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus kanzawai (species) D	Intraspecific	Candidate Gene	Aiki Yasuhiko; Kozaki Toshinori; Mizuno Hiroshi ; et al. (2005 ) Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resist[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002591	Ace P07140	Physiology	F331W	Tetranychus kanzawai (species)	Tetranychus kanzawai (species) D		Acetylcholinesterase (Ace-1)	Tetranychus kanzawai (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002592	Ace P07140	Physiology	F331C	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Candidate Gene	Carvalho Renato; Yang Yihua; Field Linda M ; et al. (2012 ) Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002593	Ace P07140	Physiology	F331W/Y	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D		Acetylcholinesterase (Ace-1)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Zhang Yueliang; Li Shuo; Xu Lu ; et al. (2013 ) Overexpression of carboxylesterase-1 and mutation (F439H) of acetylcholinesterase-1 are associated w[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002594	Ace P07140	Physiology	F331H	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D		Acetylcholinesterase (Ace-1)	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002595	Ace P07140	Physiology	L336S	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D		Acetylcholinesterase (Ace-1)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Zhang LJ; Jing YP; Li XH ; et al. (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002598	Ace P07140	Physiology	A441G	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	4 Mutations: Coding SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. 2 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Menozzi P; Shi MA; Lougarre A (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002011	Ace P07140	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00002012	Ace P07140	Physiology	Ile199Thr (position 129 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002016	Ace P07140	Physiology	Gly368Ala (position 328 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes - GGC>GCC	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002565	Ace P07140	Physiology	Phe392Trp mutation located in the acyl pocket of the active site gorge and recently shown to confer OP insensitivity in Culex tritaeniorhynchus	Bemisia tabaci (species)	Bemisia tabaci (species) D		Acetylcholinesterase (Ace-2)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002568	Ace P07140	Physiology	E73G	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Li Fei; Han Zhaojun (2004 ) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002569	Ace P07140	Physiology	F78L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		Acetylcholinesterase (Ace-2)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002570	Ace P07140	Physiology	E81K	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Kozaki T; Shono T; Tomita T ; et al. (2001) Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002575	Ace P07140	Physiology	I129V	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002576	Ace P07140	Physiology	I129V	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Temeyer KB; Li AY; Lohmeyer KH ; et al. (2008) Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002578	Ace P07140	Physiology	G227A	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		Acetylcholinesterase (Ace-2)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002579	Ace P07140	Physiology	S238G	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace-2)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002582	Ace P07140	Physiology	F290Y	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]	GP00002583	Ace P07140	Physiology	F466Y	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D		Acetylcholinesterase (Ace-2)	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002585	Ace P07140	Physiology	F368(290)L	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D		Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002586	Ace P07140	Physiology	V435(356)A	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D		Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Ceratitis capitata Mediterranean fruit fly - (species) D	Intraspecific	Candidate Gene	Magaña C; Hernández-Crespo P; Brun-Barale A ; et al. (2008) Mechanisms of resistance to malathion in the medfly Ceratitis capitata. 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002588	Ace P07140	Physiology	Gly328Ala	Ceratitis capitata Mediterranean fruit fly - (species)	Ceratitis capitata Mediterranean fruit fly - (species) D		Acetylcholinesterase (Ace-2)	Ceratitis capitata Mediterranean fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Nabeshima T; Mori A; Kozaki T ; et al. (2004) An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Ja[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002596	Ace P07140	Physiology	F331W - F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D		Acetylcholinesterase (Ace-2)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002597	Ace P07140	Physiology	W435R	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D		Acetylcholinesterase (Ace-2)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, Deletion	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008) A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...] 1 Additional References Kakani EG; Bon S; Massoulié J (2011) Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides.	GP00000038	Ace P07140	Physiology	9bp deletion of three glutamine residues at positions 642_644	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Haymer DS; Wu WJ ; et al. (2006) Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]	GP00000045	Ace P07140	Physiology	2 mutations	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D		Acetylcholinesterase (Ace)	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00002014	Ace P07140	Physiology	Ser>Gly (238 is the corresponding position in Torpedo)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
ACS11	Plant architecture (petiole-to-leaf-length ratio)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Kooke R; Kruijer W; Bours R ; et al. (2016) Genome-Wide Association Mapping and Genomic Prediction Elucidate the Genetic Architecture of Morphol[...]	GP00001235	ACS11 Q9S9U6	Morphology	several candidate amino acid changes	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ACS11	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
adenosine deaminase (AgADA)	Pathogen resistance (parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001463	ADA P00813	Physiology	c.C427T p.R143C	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		adenosine deaminase (AgADA)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
AEP2	Hybrid Incompatibility (F2 sterility)	Coding, SNP	Saccharomyces bayanus (species)	Domesticated	Linkage Mapping	Lee HY; Chou JY; Cheong L ; et al. (2008) Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast speci[...]	GP00000051	AEP2 P22136	Physiology	The region between aa 348 and aa 496 plays a critical role. When this region was further dissected in the constructs H-AEP2-bcb and H-AEP2-m3; both failed to restore respiration in the Chromosome 13 line. This result suggests that multiple critical mutations have occurred during the functional diversification of Sc-AEP2 and Sb-AEP2. Exact causing mutation(s) not determined	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)		AEP2	Saccharomyces bayanus (species)	Published - Accepted by Curator
AFGP multigene - antifreeze glycoproteins	Anti-freezing	Coding, Unknown	Dissostichus mawsoni Antarctic toothfish - (species)	Intergeneric or Higher	Candidate Gene	Chen L; DeVries AL; Cheng CH (1997) Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. 2 Additional References Cheng CC; Cziko PA; Evans CW (2006) Nonhepatic origin of notothenioid antifreeze reveals pancreatic synthesis as common mechanism in pol[...] Near TJ; Dornburg A; Kuhn KL (2012) Ancient climate change, antifreeze, and the evolutionary diversification of Antarctic fishes.	GP00000052	afgp8 P24856	Physiology	multiple modifications of a pancreatic; secreted trypsinogen; notably via multiplications of small tri-peptidic repeats	Teleostei teleost fishes - (infraclass)	Dissostichus mawsoni Antarctic toothfish - (species)		AFGP multigene - antifreeze glycoproteins	Dissostichus mawsoni Antarctic toothfish - (species)	Published - Accepted by Curator
AGAMOUS-Like6	Plant architecture Inflorescence architecture	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Huang X; Effgen S; Meyer RC ; et al. (2012) Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in[...]	GP00000053	AGL6 P29386	Morphology Morphology	Pro201Leu	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AGAMOUS-Like6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, Insertion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Cavanagh JA; Tammen I; Windsor PA ; et al. (2007) Bulldog dwarfism in Dexter cattle is caused by mutations in ACAN.	GP00002140	ACAN P16112	Morphology	2266_2267insGGCA mutation introduces a frameshift and a premature termination codon into exon 11; the frameshift occurs at amino acid position 756 ; the termination codon occurs at position 914 compared to the normal aggrecan product of 2327 amino acids N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		aggrecan	Bos taurus cattle - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Eberth JE; Graves KT; MacLeod JN ; et al. (2018) Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.	GP00002142	ACAN P16112	Morphology	g.95257458_95257500del ; p.Phe2017-Asp2023del N	Equus caballus horse - (species)	Equus caballus horse - (species) D		aggrecan	Equus caballus horse - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Metzger J; Gast AC; Schrimpf R ; et al. (2017) Whole-genome sequencing reveals a potential causal mutation for dwarfism in the Miniature Shetland p[...] 1 Additional References Eberth JE; Graves KT; MacLeod JN (2018) Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.	GP00002143	ACAN P16112	Morphology	g.95282140C>G ; p.Ala505Pro	Equus caballus horse - (species)	Equus caballus horse - (species) D		aggrecan	Equus caballus horse - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Association Mapping	Eberth JE; Graves KT; MacLeod JN ; et al. (2018) Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.	GP00002144	ACAN P16112	Morphology	g.95284530C>T ; p.Val424Met	Equus caballus horse - (species)	Equus caballus horse - (species) D		aggrecan	Equus caballus horse - (species)	Published - Accepted by Curator
aggrecan	Body size (dwarfism)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Eberth JE; Graves KT; MacLeod JN ; et al. (2018) Multiple alleles of ACAN associated with chondrodysplastic dwarfism in Miniature horses.	GP00002145	ACAN P16112	Morphology	g.95291270del ; p.Lys82fs N	Equus caballus horse - (species)	Equus caballus horse - (species) D		aggrecan	Equus caballus horse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat; dorso-ventral)	Coding, SNP N	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Candidate Gene	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00000056	Asip Q03288	Morphology	Premature stop codon at residue 65 N	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		Agouti	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Intraspecific	Linkage Mapping	Rieder S; Taourit S; Mariat D ; et al. (2001) Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their associati[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000062	Asip Q03288	Morphology	11bp deletion in exon 2: g.2174_2184del11 c.191_201del N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Agouti	Equus caballus horse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000063	Asip Q03288	Morphology	Deletion of nt 123-124 N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		Agouti	Felis catus domestic cat - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Panthera pardus leopard - (species) D	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000065	Asip Q03288	Morphology	nonsense mutation located in exon 4 (C333A) predicted to introduce a stop codon at amino acid position 111 N	Panthera pardus leopard - (species)	Panthera pardus leopard - (species) D		Agouti	Panthera pardus leopard - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP	Catopuma temminckii Asiatic golden cat - (species)	Intraspecific	Candidate Gene	Schneider A; David VA; Johnson WE ; et al. (2012) How the leopard hides its spots: ASIP mutations and melanism in wild cats.	GP00000066	Asip Q03288	Morphology	C128W (384C>G)	Catopuma temminckii Asiatic golden cat - (species)	Catopuma temminckii Asiatic golden cat - (species)		Agouti	Catopuma temminckii Asiatic golden cat - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, Deletion N	Vulpes vulpes red fox - (species) D	Domesticated	Candidate Gene	Våge DI; Lu D; Klungland H ; et al. (1997) A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes.	GP00000067	Asip Q03288	Morphology	166 bp deletion in exon 1 N	Vulpes vulpes red fox - (species)	Vulpes vulpes red fox - (species) D		Agouti	Vulpes vulpes red fox - (species)	Published - Accepted by Curator
Agouti	Coloration (feathers)	Coding, Deletion N	Coturnix japonica Japanese quail - (species) D	Domesticated	Linkage Mapping	Hiragaki T; Inoue-Murayama M; Miwa M ; et al. (2008) Recessive black is allelic to the yellow plumage locus in Japanese quail and associated with a frame[...]	GP00000068	Asip Q03288	Morphology	8bp frameshift deletion N	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species) D		Agouti	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Leopardus colocolo Colocolo - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001731	Asip Q03288	Morphology	Arg to Cys substitution in the C-terminal region of ASIP (p.R120C) lies in the critical RFF loop (e.g. a triplet motif made of one arginine and two phenylalanine residues) required for binding to the MC1R N	Leopardus colocolo Colocolo - (species)	Leopardus colocolo Colocolo - (species) D		Agouti	Leopardus colocolo Colocolo - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Leopardus guigna Kodkod - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001732	Asip Q03288	Morphology	Cys to Tyr substitution in ASIP (p.C126Y) which affects the key disulfide bond that stabilizes the RFF loop N	Leopardus guigna Kodkod - (species)	Leopardus guigna Kodkod - (species) D		Agouti	Leopardus guigna Kodkod - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	5 Mutations:	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Association Mapping	Linnen CR; Poh YP; Peterson BK ; et al. (2013) Adaptive evolution of multiple traits through multiple mutations at a single gene. 1 Additional References Barrett RDH; Laurent S; Mallarino R (2019) Linking a mutation to survival in wild mice.	GP00001974	Asip Q03288	Morphology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)		Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP N	Peromyscus maniculatus North American deer mouse - (species)	Intraspecific	Association Mapping	Kingsley EP; Manceau M; Wiley CD ; et al. (2009) Melanism in peromyscus is caused by independent mutations in agouti.	GP00001976	Asip Q03288	Morphology	recessive mutation at nucleotide position 193 (in exon 3) resulting in a change from glutamine to a stop codon at amino acid position 65 (Q65term) N	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species)		Agouti	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
Agouti	Coloration (coat)	Coding, SNP	Sciurus niger fox squirrel - (species) D	Intraspecific	Candidate Gene	McRobie HR; Moncrief ND; Mundy NI (2019) Multiple origins of melanism in two species of North American tree squirrel (Sciurus).	GP00002335		Morphology	Gly121Cys	Sciurus niger fox squirrel - (species)	Sciurus niger fox squirrel - (species) D		Agouti	Sciurus niger fox squirrel - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies)	Domesticated	Candidate Gene	Berryere TG; Kerns JA; Barsh GS ; et al. (2005) Association of an Agouti allele with fawn or sable coat color in domestic dogs.	GP00000060	Asip Q03288	Morphology	c.244G>T + 248G>A ; p.A82S + p.R83H A82S and R83H in Linkage Disequilibrium a G-to-T transversion and a G-to-A transition in exon 4 at positions corresponding to residues 244 and 248 of the cDNA sequence It is unknown if one or both substitutions alter Agouti protein function	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies)		Agouti (ASIP)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Kerns JA; Newton J; Berryere TG ; et al. (2004) Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs. 1 Additional References Berryere TG; Kerns JA; Barsh GS (2005) Association of an Agouti allele with fawn or sable coat color in domestic dogs.	GP00000061	Asip Q03288	Morphology	R96C ; g.23393552C>T c.286C>T p.R96C	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		Agouti (ASIP)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Monarcha castaneiventris Makira monarch - (species) D	Intraspecific	Association Mapping	Uy JA; Cooper EA; Cutie S ; et al. (2016) Mutations in different pigmentation genes are associated with parallel melanism in island flycatcher[...]	GP00001334	Asip Q03288	Morphology	Ile55Thr	Monarcha castaneiventris Makira monarch - (species)	Monarcha castaneiventris Makira monarch - (species) D		Agouti (ASIP)	Monarcha castaneiventris Makira monarch - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Abitbol M; Legrand R; Tiret L (2015) A missense mutation in the agouti signaling protein gene (ASIP) is associated with the no light poin[...]	GP00001335	Asip Q03288	Morphology	c.349T>C p.Cys117Arg	Equus asinus ass - (species)	Equus asinus ass - (species) D		Agouti (ASIP)	Equus asinus ass - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat) Lifespan	2 Mutations: Coding N	Ovis aries sheep - (species) D	Intraspecific	Linkage Mapping	Gratten J; Pilkington JG; Brown EA ; et al. (2010) The genetic basis of recessive self-colour pattern in a wild sheep population. 1 Additional References Gratten J; Pilkington JG; Brown EA (2012) Selection and microevolution of coat pattern are cryptic in a wild population of sheep.	GP00001356	Asip Q03288	Morphology Physiology	2 mutations	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		Agouti (ASIP)	Ovis aries sheep - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Insertion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Fontanesi L; Forestier L; Allain D ; et al. (2010) Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic an[...] 1 Additional References Sakuma Y; Matsunami M; Takada T (2019) Multiple Conserved Elements Structuring Inverted Repeats in the Mammalian Coat Color-Related Gene As[...]	GP00001968	Asip Q03288	Morphology	an insertion in exon 2 of the black nonagouti allele = c.5_6insA mutation which causes a frameshift and a predicted truncated protein of only 21 amino acids N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		Agouti (ASIP)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Deletion N	D	Intraspecific	Candidate Gene	Miller SM; Guthrie AJ; Harper CK (2016) Single base-pair deletion in ASIP exon 3 associated with recessive black phenotype in impala (Aepyce[...]	GP00001977	Asip Q03288	Morphology	recessive c.174delA was found in all black phenotype sequences ; premature stop codon (239–241 bp) N		D		Agouti (ASIP)		Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, Deletion N	Camelus dromedarius Arabian camel - (species) D	Domesticated	Candidate Gene	Almathen F; Elbir H; Bahbahani H ; et al. (2018) Polymorphisms in MC1R and ASIP Genes are Associated with Coat Color Variation in the Arabian Camel. 1 Additional References Alshanbari F; Castaneda C; Juras R (2019) Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Anal[...]	GP00001978	Asip Q03288	Morphology	1-bp deletion at position 23 resulting in frameshift N	Camelus dromedarius Arabian camel - (species)	Camelus dromedarius Arabian camel - (species) D		Agouti (ASIP)	Camelus dromedarius Arabian camel - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat)	Coding, SNP	Vicugna pacos alpaca - (species) D	Domesticated	Candidate Gene	Chandramohan B; Renieri C; La Manna V ; et al. (2013) The alpaca agouti gene: genomic locus, transcripts and causative mutations of eumelanic and pheomela[...]	GP00002336	Asip Q03288	Morphology	p.R98C likely affecting conformation in a cysteine-rich domain	Vicugna pacos alpaca - (species)	Vicugna pacos alpaca - (species) D		Agouti (ASIP)	Vicugna pacos alpaca - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat; dorso-ventral)	Coding, Insertion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Letko A; Ammann B; Jagannathan V ; et al. (2020) A deletion spanning the promoter and first exon of the hair cycle-specific ASIP transcript isoform i[...]	GP00002373	Asip Q03288	Morphology	"The structural variant represented an approximately 11 kb deletion (NC_013672.1:g.5,455,408_5,466,123del; Fig. 2). In rabbit, there are currently two ASIP transcript isoforms annotated (NCBI annotation release 102). The deletion removes the entire first 5′-untranslated exon of one of these transcripts (NM_001122939.1). (...) he deletion removed the transcription start site and the first untranslated exon of the presumably hair cycle-specific transcript isoform, suggesting that this is the most likely causative variant for the black and tan phenotype." N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		Agouti (ASIP)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (polycyclic aromatic hydrocarbons; TCDD)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Linkage Mapping	Poland A; Palen D; Glover E (1994) Analysis of the four alleles of the murine aryl hydrocarbon receptor.	GP00001810	Ahr P30561	Physiology	alanine at position 375 mutated into valine; decreases the affinity 4-fold	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		AHR	Mus musculus house mouse - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (dioxins; polycyclic aromatic hydrocarbons; TCDD)	2 Mutations: Coding SNP	Sterna hirundo hirundo (subspecies) D	Intergeneric or Higher	Candidate Gene	Karchner SI; Franks DG; Kennedy SW ; et al. (2006) The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon recep[...] 1 Additional References Head JA; Hahn ME; Kennedy SW (2008) Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species.	GP00001811	Ahr P30561	Physiology	2 mutations	Gallus gallus chicken - (species)	Sterna hirundo hirundo (subspecies) D		AHR	Sterna hirundo hirundo (subspecies)	Published - Accepted by Curator
AHR	Xenobiotic resistance (TCDD)	Coding, SNP N	Rattus norvegicus Norway rat - (species) D	Intraspecific	Linkage Mapping	Tuomisto JT; Viluksela M; Pohjanvirta R ; et al. (1999) The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resista[...] 2 Additional References Moffat ID; Roblin S; Harper PA (2007) Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transac[...] Pohjanvirta R; Wong JM; Li W (1998) Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon[...]	GP00001813	Ahr P30561	Physiology	point mutation in the exon/intron 10 boundary in AHR genomic structure that leads to use of 3 alternative cryptic splice sites; potentially creating 3 alternative transcripts and 2 protein products. At the protein level the mutation leads to a total loss of either 43 or 38 amino acids (with altered sequence for the last seven amino acids in the latter case) toward the carboxyl-terminal end in the trans-activation domain of the AhR. H/W rats also harbor a point mutation in exon 10 that will cause a Val-to-Ala substitution in codon 497, but this occurs in a variable region of the AhR N	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D		AHR	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution; polychlorinated biphenyls; PCBs)	Coding, Deletion N	Microgadus tomcod Atlantic tomcod - (species) D	Intraspecific	Candidate Gene	Wirgin I; Roy NK; Loftus M ; et al. (2011) Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.	GP00001809	Ahr P30561	Physiology	6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain N	Microgadus tomcod Atlantic tomcod - (species)	Microgadus tomcod Atlantic tomcod - (species) D		AHR2	Microgadus tomcod Atlantic tomcod - (species)	Published - Accepted by Curator
AIM22	F2 lethality	Coding, SNP	Saccharomyces bayanus (species)	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000073	AIM22 P47051	Physiology	Several candidate non-synonymous changes - exact causing mutation(s) unknown	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)		AIM22	Saccharomyces bayanus (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	6 Mutations:	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Choudhary M; Laurie CC (1991) Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...] 4 Additional References Laurie CC; Bridgham JT; Choudhary M (1991) Associations between DNA sequence variation and variation in expression of the Adh gene in natural p[...] King EG; Merkes CM; McNeil CL (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource. Siddiq MA; Loehlin DW; Montooth KL (2017) Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaste[...] Loehlin DW; Ames JR; Vaccaro K (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001962	Adh P00334	Physiology	6 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila yakuba (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001963	Adh P00334	Physiology	4 mutations	Drosophila santomea (species)	Drosophila yakuba (species)		alcohol dehydrogenase (Adh)	Drosophila yakuba (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila erecta (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001964	Adh P00334	Physiology	4 mutations	Drosophila orena (species)	Drosophila erecta (species)		alcohol dehydrogenase (Adh)	Drosophila erecta (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Vigue C; Sofer W (1974) Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.	GP00001988	Adh P00334	Physiology	Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Freeth AL; Gibson JB; Wilks AV (1990) Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...] 1 Additional References Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001990	Adh P00334	Physiology	eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001991	Adh P00334	Physiology	438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)	Xenobiotic resistance (alcohol)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Li H; Mukherjee N; Soundararajan U ; et al. (2007) Geographically separate increases in the frequency of the derived ADH1B47His allele in eastern and [...] 1 Additional References Li H; Mukherjee N; Soundararajan U (2007)* Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]	GP00000077	ADH1B P00325	Physiology	Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication	Homo sapiens human - (species)	Homo sapiens human - (species) D		alcohol dehydrogenase (ADH1B)	Homo sapiens human - (species)	Published - Accepted by Curator
Aldehyde dehydrogenase (Aldh)	Xenobiotic resistance (alcohol)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Fry JD; Donlon K; Saweikis M (2008) A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selectio[...]	GP00002007	Aldh Q9VLC5	Physiology	L479F C9391311T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Aldehyde dehydrogenase (Aldh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Alk / Starch Synthase II	Grain cooking texture	4 Mutations: Coding SNP	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Umemoto T; Yano M; Satoh H ; et al. (2002) Mapping of a gene responsible for the difference in amylopectin structure between japonica-type and [...] 2 Additional References Nakamura Y; Francisco PB; Hosaka Y (2005) Essential amino acids of starch synthase IIa differentiate amylopectin structure and starch quality [...] Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000078	SSII-3 Q0DDE3	Physiology	4 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Alk / Starch Synthase II	Oryza sativa rice - (species)	Published - Accepted by Curator
Allantoin permease DAL4	Nitrogen use (growth rate on allantoin)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001503	DAL4 Q04895	Physiology	c.1201delA a single nucleotide frameshifting insertion (deletion?) N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Allantoin permease DAL4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Allantoinase DAL1	Nitrogen use (growth rate on allantoin)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001502	DAL1 P32375	Physiology	c.415C>T p.P139S predicted to be strongly detrimental	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Allantoinase DAL1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001893	ALS P17597	Physiology	W574L	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001894	ALS P17597	Physiology	S653N	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001895	ALS P17597	Physiology	S653T	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ameloblastin (AMBN)	Tooth absence (no enamel production)	Coding, Unknown N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Deméré TA; McGowen MR; Berta A ; et al. (2008) Morphological and molecular evidence for a stepwise evolutionary transition from teeth to baleen in [...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001938	AMBN Q9NP70	Physiology	multiple frameshift mutations N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D		ameloblastin (AMBN)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
amelogenin (AMEL)	Tooth absence (no enamel production)	3 Mutations: Coding N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001933	Amelx P63277	Physiology	3 mutations	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D		amelogenin (AMEL)	Gallus gallus chicken - (species)	Published - Accepted by Curator
amelogenin (AMEL)	Tooth absence (no enamel production)	Coding, Unknown N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001937	Amelx P63277	Physiology	J. Gatesy 2010 unpublished data cited in the main reference N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D		amelogenin (AMEL)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
Amhr2	Sex determination (female vs male)	Coding, SNP	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Intraspecific	Linkage Mapping	Kamiya T; Kai W; Tasumi S ; et al. (2012) A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, [...]	GP00002147	AMHR2 Q16671	Physiology	His/Asp384 heterozygous males have reduced Amrh2 activity due to decreased activity of the kinase signaling domain	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)		Amhr2	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Published - Accepted by Curator
Aminopeptidase N (APN)	Xenobiotic resistance (insecticide; Bt Cry2Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Experimental Evolution	Candidate Gene	Yang Y; Zhu YC; Ottea J ; et al. (2010) Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacil[...]	GP00002463	apn Q9VFX3	Physiology	deletion removing 22 amino acids. The mutant form failed to bind Cry1Ac unlike the full-length susceptible form. N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Aminopeptidase N (APN)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
AMN1	Cell separation	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Yvert G; Brem RB; Whittle J ; et al. (2003) Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.	GP00000082	AMN1 P38285	Physiology	D368V	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		AMN1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000089	AN2 A4GRU8	Morphology	1bp deletion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000090	AN2 A4GRU8	Morphology	4bp insertion at a.a. 127; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Intraspecific	Candidate Gene	Quattrocchio F; Wing J; van der Woude K ; et al. (1999) Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]	GP00000091	AN2 A4GRU8	Morphology	W196* N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, Deletion N	Petunia axillaris (species) D	Intraspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000092	AN2 A4GRU8	Morphology	1bp deletion; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species) D		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000093	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
anthocyanin2 (an2)	Coloration (flowers)	Coding, SNP N	Petunia axillaris (species)	Interspecific	Candidate Gene	Hoballah ME; Gübitz T; Stuurman J ; et al. (2007) Single gene-mediated shift in pollinator attraction in Petunia.	GP00000094	AN2 A4GRU8	Morphology	1 aa substitution; premature stop N	Petunia integrifolia (species)	Petunia axillaris (species)		anthocyanin2 (an2)	Petunia axillaris (species)	Published - Accepted by Curator
AOP2	Glucosinolate content	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000095	AOP2 Q945B5	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AOP2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AOP3	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000096	AOP3 Q9ZTA1	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AOP3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
apicoplast ribosomal protein S10	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001531	PF3D7_1460900.1 Q8IKM3	Physiology	p.Val127Met	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		apicoplast ribosomal protein S10	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
APOE (apolipoprotein E)	Aging	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000099	APOE P02649	Physiology	Cys112Arg	Homo sapiens human - (species)	Homo sapiens human - (species)		APOE (apolipoprotein E)	Homo sapiens human - (species)	Published - Accepted by Curator
APSR	Sulfate content (shoot)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007) Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.	GP00000100	APR2 P92981	Physiology	A399E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		APSR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Aquaporin	Water transport (selective accumulation of water or glycerol)	Coding, SNP	Polypedilum vanderplanki sleeping chironomid - (species)	Interspecific	Candidate Gene	Finn RN; Chauvigné F; Stavang JA ; et al. (2015) Insect glycerol transporters evolved by functional co-option and gene replacement.	GP00001421	AQP1 P29972	Physiology	p.His174Ala	Blattella germanica German cockroach - (species)	Polypedilum vanderplanki sleeping chironomid - (species)		Aquaporin	Polypedilum vanderplanki sleeping chironomid - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	2 Mutations: Coding SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001872	AQP1 P29972	Physiology	2 mutations	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001873	AQP1 P29972	Physiology	aquaporin yeast 1 gene on chromosome 12 - A881 deletion renders AQY1 inactive - size of the deletion not indicated in the paper - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001874	AQP1 P29972	Physiology	aquaporin yeast 1 gene on chromosome 12 - 955-bp deletion that removes the first 106 bp of AQY1 and its upstream region - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Carbrey JM; Bonhivers M; Boeke JD (2001) Aquaporins in Saccharomyces: Characterization of a second functional water channel protein.	GP00001875	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - 11-bp deletion that creates a stop codon in the middle of the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Laizé V; Tacnet F; Ripoche P (2000) Polymorphism of Saccharomyces cerevisiae aquaporins.	GP00001876	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - deletion of nucleotide G at position 25 (G25) which creates a frameshift the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]	GP00001877	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - G528 deletion which creates a frameshift the AQY2 gene - tested in assays - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
arcp-1	CO2 avoidance Aggregation behavior	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Beets I; Zhang G; Fenk LA ; et al. (2019) Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Alteri[...]	GP00002067	CELE_F34D10.6 C6KRH4	Behavior Behavior	8 bp deletion (mfP22) in the open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		arcp-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
arginyl-transfer RNA synthetase (RARS)	Heat tolerance	Coding, SNP	Anolis cristatellus (species) D	Intraspecific	Association Mapping	Campbell-Staton SC; Winchell KM; Rochette NC ; et al. (2020) Parallel selection on thermal physiology facilitates repeated adaptation of city lizards to urban he[...]	GP00002620	RARS2 Q5T160	Physiology	C>G threonine>serine at amino acid residue 558 of the RARS gene = adjacent to a predicted protein-binding region22 (AA556–557). There are four non-synonymous polymorphic sites within RARS. Only one shows a significant difference in allele frequency between forest and urban habitats across all populations.	Anolis cristatellus (species)	Anolis cristatellus (species) D		arginyl-transfer RNA synthetase (RARS)	Anolis cristatellus (species)	Published - Accepted by Curator
ARHGAP11B	Neocortex development (basal progenitor amplification)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Florio M; Namba T; Pääbo S ; et al. (2016) A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.	GP00001442	ARHGAP11B Q3KRB8	Morphology	c.661C>G new splice site mutation removing 55nt from exon 5 truncating a GAP domain N	Homo sapiens human - (species)	Homo sapiens human - (species) D		ARHGAP11B	Homo sapiens human - (species)	Published - Accepted by Curator
ARHGAP15	Pathogen resistance (Trypanosoma)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Noyes H; Brass A; Obara I ; et al. (2011) Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]	GP00000103	Arhgap15 Q811M1	Physiology	H282P	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		ARHGAP15	Bos taurus cattle - (species)	Published - Accepted by Curator
ASP1	Acetic acid production	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Marullo P; Aigle M; Bely M ; et al. (2007) Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cere[...]	GP00000104	APS1 P35181	Physiology	Asp142His	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		ASP1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000107	GA20OX1 Q39110	Morphology	-2bp at +297 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000108	GA20OX1 Q39110	Morphology	-1bp "G" at +324 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000109	GA20OX1 Q39110	Morphology	-5bp "G" at +545 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000110	GA20OX1 Q39110	Morphology	-10bp "G" at +784 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000111	GA20OX1 Q39110	Morphology	-29bp at +426 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000112	GA20OX1 Q39110	Morphology	-444bp at +985 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000113	GA20OX1 Q39110	Morphology	+1bp "G" at +256 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000114	GA20OX1 Q39110	Morphology	+7bp "G" at +961 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000115	GA20OX1 Q39110	Morphology	+1bp at +1270 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000116	GA20OX1 Q39110	Morphology	Transposon insertion at +1355 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000117	GA20OX1 Q39110	Morphology	W46* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...] 1 Additional References Xu YL; Li L; Wu K (1995) The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cl[...]	GP00000118	GA20OX1 Q39110	Morphology	W271* -G816A according to Fig.3 of Xu et al. 1995 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000119	GA20OX1 Q39110	Morphology	E312* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000120	GA20OX1 Q39110	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism) Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000121	GA20OX1 Q39110	Morphology Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000122	GA20OX1 Q39110	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00000123	GA20OX1 Q39110	Morphology	Splice Site mutation G742A	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Luo Y; Dong X; Yu T ; et al. (2015) A Single Nucleotide Deletion in Gibberellin20-oxidase1 Causes Alpine Dwarfism in Arabidopsis.	GP00001243	GA20OX1 Q39110	Morphology	-1bp at position 184 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)	Plant size (dwarfism)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Barboza L; Effgen S; Alonso-Blanco C ; et al. (2013) Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution d[...]	GP00001685	GA20OX1 Q39110	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtGA20ox1 (=GA5=Sd1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtMYC1	Trichome density (leaf)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Symonds VV; Hatlestad G; Lloyd AM (2011) Natural allelic variation defines a role for ATMYC1: trichome cell fate determination. 1 Additional References Symonds VV; Godoy AV; Alconada T (2005) Mapping quantitative trait loci in multiple populations of Arabidopsis thaliana identifies natural a[...]	GP00001268	BHLH12 Q8W2F1	Morphology	P189A	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		AtMYC1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	3 Mutations: Coding N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001909	ATP4B P51164	Physiology	3 mutations	Monodelphis domestica gray short-tailed opossum - (species) Homo sapiens human - (species)	Ornithorhynchus anatinus platypus - (species) D		ATP4B	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
ATR13	Pathogenicity	Coding, SNP	Hyaloperonospora parasitica (species)	Intraspecific	Linkage Mapping	Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004) Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. 1 Additional References Allen RL; Meitz JC; Baumber RE (2008) Natural variation reveals key amino acids in a downy mildew effector that alters recognition specifi[...]	GP00000128	Atr13 Q5G7K8	Physiology	Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown	Hyaloperonospora parasitica (species)	Hyaloperonospora parasitica (species)		ATR13	Hyaloperonospora parasitica (species)	Published - Accepted by Curator
B4GALT7	Body size (dwarfism)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Association Mapping	Leegwater PA; Vos-Loohuis M; Ducro BJ ; et al. (2016) Dwarfism with joint laxity in Friesian horses is associated with a splice site mutation in B4GALT7.	GP00002151	B4GALT7 Q9UBV7	Morphology	g.3,772,591C>T ; c.50G>A ; p.R17K ; last nucleotide of exon 1 and leads to a splicing deficiency of B4GALT7 transcripts ; All 29 dwarfs of which DNA was available were homozygous for the mutation . . . the 8 obligate carriers were heterozygous	Equus caballus horse - (species)	Equus caballus horse - (species) D		B4GALT7	Equus caballus horse - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Juwattanasomran R; Somta P; Chankaew S ; et al. (2011) A SNP in GmBADH2 gene associates with fragrance in vegetable soybean variety "Kaori" and SNAP marker[...]	GP00000133	BADH2 Q84LK3	Physiology	1 amino-acid substitution in conserved enzymatic domain	Glycine max soybean - (species)	Glycine max soybean - (species)		BADH2	Glycine max soybean - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Bradbury LM; Fitzgerald TL; Henry RJ ; et al. (2005) The gene for fragrance in rice. 1 Additional References Kovach MJ; Calingacion MN; Fitzgerald MA (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00000134	BADH2 Q84LK3	Physiology	8bp deletion resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Shi Weiwei; Yang Yi; Chen Saihua ; et al. (2008 ) Discovery of a new fragrance allele and the development of functional markers for the breeding of fr[...] 1 Additional References Kovach MJ; Calingacion MN; Fitzgerald MA (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001772	BADH2 Q84LK3	Physiology	7-bp deletion in exon 2 resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001773	BADH2 Q84LK3	Physiology	2-bp deletion in exon 1 resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001774	BADH2 Q84LK3	Physiology	insertion of 1 bp (T) in exon 10 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001775	BADH2 Q84LK3	Physiology	G>T substitution in exon 10 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001776	BADH2 Q84LK3	Physiology	G>T substitution in exon 14 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001777	BADH2 Q84LK3	Physiology	C>T substitution in exon 13 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001778	BADH2 Q84LK3	Physiology	1-bp deletion in exon 10 - causes a frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001779	BADH2 Q84LK3	Physiology	1-bp insertion (G) in exon 14 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001780	BADH2 Q84LK3	Physiology	3-bp insertion (TAT) in exon 13 - causes a frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BBS9 (+ BMPER)	Growth rate	Coding, Deletion N	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Association Mapping	Derks MFL; Lopes MS; Bosse M ; et al. (2018) Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes[...]	GP00002341	Bbs9 Q811G0	Physiology	212kb deletion resulting in truncated BBS9 protein and recessive loss of neighbor gene expression BMPER N	Sus scrofa domesticus domestic pig - (subspecies)	Sus scrofa domesticus domestic pig - (subspecies) D		BBS9 (+ BMPER)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
BCMA	Glucosinolate content Herbivore resistance	3 Mutations:	Boechera stricta (species)	Intraspecific	Linkage Mapping	Prasad KV; Song BH; Olson-Manning C ; et al. (2012) A gain-of-function polymorphism controlling complex traits and fitness in nature.	GP00000136	J9QWI9	Physiology Physiology	3 mutations	Boechera stricta (species)	Boechera stricta (species)		BCMA	Boechera stricta (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow serum)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Berry SD; Davis SR; Beattie EM ; et al. (2009) Mutation in bovine beta-carotene oxygenase 2 affects milk color. 1 Additional References Tian R; Pitchford WS; Morris CA (2010) Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colou[...]	GP00000138	BCO2 Q9BYV7	Physiology	c.306G>A ; p.W102* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		BCO2 = beta-carotene oxygenase 2	Bos taurus cattle - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow fat)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Våge DI; Boman IA (2010) A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumula[...] 1 Additional References Niu Y; Jin M; Li Y (2017) Biallelic β-carotene oxygenase 2 knockout results in yellow fat in sheep via CRISPR/Cas9.	GP00000140	BCO2 Q9BYV7	Physiology	g.21947481C>T ; c.196C>T ; p.Q66* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BCO2 = beta-carotene oxygenase 2	Ovis aries sheep - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (bill, legs)	Coding, SNP N	Serinus canaria common canary - (species) D	Domesticated	Association Mapping	Gazda MA; Toomey MB; Araújo PM ; et al. (2020) GENETIC BASIS OF DE NOVO APPEARANCE OF CAROTENOID ORNAMENTATION IN BARE-PARTS OF CANARIES.	GP00002039	BCO2 Q9BYV7	Morphology	point mutation at nucleotide position 837,806 that is predicted to be a nonsynonymous mutation in the exon 9 of the BCO2 gene. This variant results in the substitution of a histidine for an arginine at residue 413 of the protein (R413H) . In silico analysis suggests that the R413H could cause structural distortion of the protein and lead to a possible loss of activity. In vitro assays with the urucum BCO2 variant show that the enzyme activity is lost. N	Serinus canaria common canary - (species)	Serinus canaria common canary - (species) D		BCO2 = beta-carotene oxygenase 2	Serinus canaria common canary - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow fat)	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Strychalski J; Brym P; Czarnik U ; et al. (2015) A novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits.	GP00002152	BCO2 Q9BYV7	Physiology	AAT-deletion mutation at Asp codon 248 of the BCO2 gene located at the beginning of exon 6 which results in the removal of an Asp N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		BCO2 = beta-carotene oxygenase 2	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
beta-casein	Milk protein content (casein)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Gallinat JL; Qanbari S; Drögemüller C ; et al. (2013) DNA-based identification of novel bovine casein gene variants.	GP00002025	CSN2 P02666	Physiology	g.87181619A>C c.245A>C p.H82P CAT>CCT	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		beta-casein	Bos taurus cattle - (species)	Published - Accepted by Curator
beta-defensin 103 (CBD103)	Coloration (coat)	Coding, Deletion	Canis lupus familiaris dog - (subspecies) D Canis latrans coyote - (species) D Canis lupus gray wolf - (species) D	Domesticated	Linkage Mapping	Candille SI; Kaelin CB; Cattanach BM ; et al. (2007) A -defensin mutation causes black coat color in domestic dogs. 2 Additional References Anderson TM; vonHoldt BM; Candille SI (2009) Molecular and evolutionary history of melanism in North American gray wolves. Schweizer RM; Durvasula A; Smith J (2018) Natural Selection and Origin of a Melanistic Allele in North American Gray Wolves.	GP00000141	CBD103 Q30KV0	Morphology; Physiology	3bp in-frame deletion in exon 2 = deletion of Gly23	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D Canis latrans coyote - (species) D Canis lupus gray wolf - (species) D		beta-defensin 103 (CBD103)	Canis lupus familiaris dog - (subspecies) Canis latrans coyote - (species) Canis lupus gray wolf - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001263	BGLU6 Q682B4	Physiology	T-> A of a splice site at position 168 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001264	BGLU6 Q682B4	Physiology	1-bp deletion of a splice site at position 395 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001265	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 913 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001266	BGLU6 Q682B4	Physiology	A deletion of one nucleotide in the seventh exon (BGLU6 CDS position 678) results in a premature stop codon in the accessions Bor-4, Se-0, Uod-1, and Zdr-1. premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001267	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 1138 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Kwa MS; Veenstra JG; Roos MH (1994) Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001785	TUB2 P02557	Physiology	Phe200Tyr	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D		beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Trichostrongylus colubriformis (species) D	Intraspecific	Candidate Gene	Kwa MS; Veenstra JG; Roos MH (1994) Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001786	TUB2 P02557	Physiology	Phe200Tyr	Trichostrongylus colubriformis (species)	Trichostrongylus colubriformis (species) D		beta-tubulin	Trichostrongylus colubriformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001788	TUB2 P02557	Physiology	Phe200Tyr	Venturia inaequalis (species)	Venturia inaequalis (species) D		beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001789	TUB2 P02557	Physiology	Phe200Tyr		D		beta-tubulin		Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium italicum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001790	TUB2 P02557	Physiology	Phe200Tyr	Penicillium italicum (species)	Penicillium italicum (species) D		beta-tubulin	Penicillium italicum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium aurantiogriseum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001791	TUB2 P02557	Physiology	Phe200Tyr	Penicillium aurantiogriseum (species)	Penicillium aurantiogriseum (species) D		beta-tubulin	Penicillium aurantiogriseum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium aurantiogriseum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001792	TUB2 P02557	Physiology	Glu198Lys	Penicillium aurantiogriseum (species)	Penicillium aurantiogriseum (species) D		beta-tubulin	Penicillium aurantiogriseum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium viridicatum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001793	TUB2 P02557	Physiology	Glu198Lys	Penicillium viridicatum (species)	Penicillium viridicatum (species) D		beta-tubulin	Penicillium viridicatum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Clarireedia homoeocarpa (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001794	TUB2 P02557	Physiology	Glu1198Lys	Clarireedia homoeocarpa (species)	Clarireedia homoeocarpa (species) D		beta-tubulin	Clarireedia homoeocarpa (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001795	TUB2 P02557	Physiology	Glu1198Lys	Venturia inaequalis (species)	Venturia inaequalis (species) D		beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001796	TUB2 P02557	Physiology	Glu1198Ala	Venturia inaequalis (species)	Venturia inaequalis (species) D		beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001797	TUB2 P02557	Physiology	Glu1198Ala		D		beta-tubulin		Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Monilinia fructicola (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001798	TUB2 P02557	Physiology	Glu1198Lys	Monilinia fructicola (species)	Monilinia fructicola (species) D		beta-tubulin	Monilinia fructicola (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium puberulum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001799	TUB2 P02557	Physiology	Glu1198Lys	Penicillium puberulum (species)	Penicillium puberulum (species) D		beta-tubulin	Penicillium puberulum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium puberulum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001800	TUB2 P02557	Physiology	Glu1198Ala	Penicillium puberulum (species)	Penicillium puberulum (species) D		beta-tubulin	Penicillium puberulum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium digitatum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001801	TUB2 P02557	Physiology	Glu1198Lys	Penicillium digitatum (species)	Penicillium digitatum (species) D		beta-tubulin	Penicillium digitatum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium expansum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001802	TUB2 P02557	Physiology	Glu1198Ala	Penicillium expansum (species)	Penicillium expansum (species) D		beta-tubulin	Penicillium expansum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium italicum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001803	TUB2 P02557	Physiology	Glu198Lys	Penicillium italicum (species)	Penicillium italicum (species) D		beta-tubulin	Penicillium italicum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Teladorsagia circumcincta (species) D	Intraspecific	Candidate Gene	Elard L; Humbert JF (1999) Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole[...]	GP00001815	TUB2 P02557	Physiology	Phe200Tyr	Teladorsagia circumcincta (species)	Teladorsagia circumcincta (species) D		beta-tubulin	Teladorsagia circumcincta (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Prichard R; Oxberry M; Bounhas Y ; et al. (2000 ) Polymerisation and benzimidazole binding assays with recombinant α-and β-tubulins from Haemonchus co[...] 2 Additional References Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...] Li J; Katiyar SK; Edlind TD (1996) Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 [...]	GP00001816	TUB2 P02557	Physiology	Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus b-tubulin (produced in a prokaryote system)	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D		beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Cyathostoma (genus) D	Intraspecific	Candidate Gene	Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...] 1 Additional References Li J; Katiyar SK; Edlind TD (1996) Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 [...]	GP00001817	TUB2 P02557	Physiology	Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus and S. cerevisiae b-tubulin (produced in a prokaryote system)	Cyathostoma (genus)	Cyathostoma (genus) D		beta-tubulin	Cyathostoma (genus)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Neurospora crassa (species) D	Intraspecific	Candidate Gene	Orbach MJ; Porro EB; Yanofsky C (1986) Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurosp[...]	GP00001818	TUB2 P02557	Physiology	Phe167Tyr	Neurospora crassa (species)	Neurospora crassa (species) D		beta-tubulin	Neurospora crassa (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Teladorsagia circumcincta (species) D	Intraspecific	Candidate Gene	Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]	GP00001819	TUB2 P02557	Physiology	Phe167Tyr	Teladorsagia circumcincta (species)	Teladorsagia circumcincta (species) D		beta-tubulin	Teladorsagia circumcincta (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Ghisi M; Kaminsky R; Mäser P (2007) Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutatio[...]	GP00001820	TUB2 P02557	Physiology	Glu198Ala	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D		beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]	GP00001821	TUB2 P02557	Physiology	Phe200Tyr	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]	GP00001822	TUB2 P02557	Physiology	Phe200Tyr	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001823	TUB2 P02557	Physiology	E198A	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001824	TUB2 P02557	Physiology	E198G	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001825	TUB2 P02557	Physiology	E198K	Oculimacula acuformis (species)	Oculimacula acuformis (species) D		beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001826	TUB2 P02557	Physiology	E198A	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001827	TUB2 P02557	Physiology	E198G	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001828	TUB2 P02557	Physiology	E198Q	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001829	TUB2 P02557	Physiology	L240F	Oculimacula yallundae (species)	Oculimacula yallundae (species) D		beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001830	TUB2 P02557	Physiology	A185P - missense_variant_c.553G>C_3539974 – A185P N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001832	TUB2 P02557	Physiology	stop_gained_HIGH_c.1267C>T_3538394 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001833	TUB2 P02557	Physiology	Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001834	TUB2 P02557	Physiology	missense_variant_MODERATE_c.1210G>A_3538451 – D404N N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001835	TUB2 P02557	Physiology	Del_3539006_3539808 – 802bp deletion of coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001836	TUB2 P02557	Physiology	stop_gained_HIGH_c.1135A>T_3539335 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001837	TUB2 P02557	Physiology	stop_gained_HIGH_c.1112C>A_3539358 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001838	TUB2 P02557	Physiology	Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001839	TUB2 P02557	Physiology	Del_3539470_3539471 – 1bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001840	TUB2 P02557	Physiology	Del_3539507_3539514 – 7bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001841	TUB2 P02557	Physiology	Del_3539559_3539745 – 186 bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001842	TUB2 P02557	Physiology	Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001843	TUB2 P02557	Physiology	missense_variant_MODERATE_c.771G>A_3539699 – M257I N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001844	TUB2 P02557	Physiology	Del_3539746_3539908 – 162 bp deletion in exon3-4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001845	TUB2 P02557	Physiology	stop_gained_HIGH_c.549C>A_3539978 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001846	TUB2 P02557	Physiology	missense_variant_MODERATE_c.434C>T_3540145 – S145F N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001847	TUB2 P02557	Physiology	missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001848	TUB2 P02557	Physiology	Del_3540300_3540301 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Inversion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001849	TUB2 P02557	Physiology	Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Unknown N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001850	TUB2 P02557	Physiology	Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001851	TUB2 P02557	Physiology	Del_3540407_3540408 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001852	TUB2 P02557	Physiology	Del_3540970_3544000 – 3030bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001853	TUB2 P02557	Physiology	Del_3541317_3541856 – 539 bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001854	TUB2 P02557	Physiology	splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001855	TUB2 P02557	Physiology	stop_gained_HIGH_c.153T>G_3541441 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001856	TUB2 P02557	Physiology	Del_3541499_3541502 – 3bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001857	TUB2 P02557	Physiology	Ins_3541547_3541548 – 1 bp insertion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben4)	Xenobiotic resistance (benzimidazole)	Coding, SNP	Aspergillus nidulans (species) D	Intraspecific	Candidate Gene	Jung MK; Wilder IB; Oakley BR (1992) Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl r[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001787	TUB2 P02557	Physiology	Phe200Tyr	Aspergillus nidulans (species)	Aspergillus nidulans (species) D		beta-tubulin (ben4)	Aspergillus nidulans (species)	Published - Accepted by Curator
Bh4	Coloration (seed hull)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Zhu BF; Si L; Wang Z ; et al. (2011) Genetic control of a transition from black to straw-white seed hull in rice domestication. 1 Additional References Huang X; Kurata N; Wei X (2012) A map of rice genome variation reveals the origin of cultivated rice.	GP00000143	Bh4 A0A0H3ZGK8	Morphology	22-bp deletion N	Oryza rufipogon (species)	Oryza sativa rice - (species) D		Bh4	Oryza sativa rice - (species)	Published - Accepted by Curator
bHLH2	Coloration (flower; seed)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Park KI; Ishikawa N; Morita Y ; et al. (2007) A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthe[...]	GP00002078	BHLH2 Q9CAD0	Morphology	two copies of 3.9-kb Tip100 integrated into bHLH2 exon 7 and intron 2 N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		bHLH2	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
bHLH2	Coloration (flower; seed)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Park KI; Ishikawa N; Morita Y ; et al. (2007) A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthe[...]	GP00002085	BHLH2 Q9CAD0	Morphology	only one copy of Tip100 in exon 7 and no apparent footprint of Tip100 in intron 2 N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		bHLH2	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
bHLH2	Coloration (flower; seed)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Park KI; Ishikawa N; Morita Y ; et al. (2007) A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthe[...]	GP00002086	BHLH2 Q9CAD0	Morphology	insertion of 838 bp IpMu1 in exon 2 N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		bHLH2	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
bHLH2	Coloration (flowers; seeds)	Coding, Insertion N	Ipomoea tricolor (species) D	Domesticated	Candidate Gene	Park KI; Choi JD; Hoshino A ; et al. (2004) An intragenic tandem duplication in a transcriptional regulatory gene for anthocyanin biosynthesis c[...]	GP00002091	BHLH2 Q9CAD0	Morphology	intragenic tandem duplication of 3.3 kbp of the bHLH2 gene. Each of the tandem repeats is flanked by a 3-bp sequence AAT; indicating that the 3-bp microhomology is used to generate the tandem duplication. The transcripts in the pale-blue flower buds of the mutant contain an internal 583-bp tandem duplication that results in the production of a truncated polypeptide lacking the bHLH domain. The mRNA accumulation of most of the structural genes encoding enzymes for anthocyanin biosynthesis in the flower buds of the mutant was significantly reduced. The transcripts identical to the wild-type mRNAs for the transcriptional activator were present abundantly in blue spots of the variegated flowers whereas the transcripts containing the 583-bp tandem duplication were predominant in the pale-blue background of the same flowers. The flower and seed variegations studied here are likely to be caused by somatic homologous recombination between an intragenic tandem duplication in the gene encoding a bHLH transcriptional activator for anthocyanin biosynthesis. N	Ipomoea tricolor (species)	Ipomoea tricolor (species) D		bHLH2	Ipomoea tricolor (species)	Published - Accepted by Curator
bHLH2	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Domesticated	Candidate Gene	Spelt C; Quattrocchio F; Mol J ; et al. (2002) ANTHOCYANIN1 of petunia controls pigment synthesis, vacuolar pH, and seed coat development by geneti[...]	GP00002092	BHLH2 Q9CAD0	Morphology	insertion of a dTph1 transposon in the AN1 gene N	Petunia axillaris (species)	Petunia axillaris (species) D		bHLH2	Petunia axillaris (species)	Published - Accepted by Curator
Bm-iAANAT	Coloration (larva)	Coding, Deletion N	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Zhan S; Guo Q; Li M ; et al. (2010) Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation. 1 Additional References Dai FY; Qiao L; Tong XL (2010) Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism[...]	GP00000145	Aanat D6MKR2	Morphology	126-bp deletion overlapping with end of exon 4 and resulting in misplicing. Linkage analysis and genomic studies have shown that Bombyx arylalkamine-N-acetyl transferase, the homologous gene (Dat) that converts dopamine into N-acetyl dopamine, encodes a precursor of N-acetyl dopamine, sclerotin in Drosophila and it is the gene responsible for mln. N	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D		Bm-iAANAT	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001488	BMH1 P29311	Physiology	C>G p.Y216* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001489	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001490	BMH1 P29311	Physiology	A>T p.K217* (2 times independently). Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001491	BMH1 P29311	Physiology	G>A p.D101N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001492	BMH1 P29311	Physiology	T>G p.L230* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001493	BMH1 P29311	Physiology	C>A p.N178K located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001494	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001495	BMH1 P29311	Physiology	G>T p.G174V homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001496	BMH1 P29311	Physiology	G>A p.G174D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001497	BMH1 P29311	Physiology	A>G p.N178S homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001498	BMH1 P29311	Physiology	G>A p.G55D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMP receptor IB (BMPRIB)	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Mulsant P; Lecerf F; Fabre S ; et al. (2001) Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Bo[...]	GP00000146	BMPR-IB Q9BDI4	Physiology	g.29382188A>G c.914A>G p.Q305R	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP receptor IB (BMPRIB)	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000147	Bmp15 Q9Z0L4	Physiology	c.67C>T p.Q23* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000148	Bmp15 Q9Z0L4	Physiology	A distinct single T>A transition occurs in FecXI carriers at nucleotide position 92 of the mature peptide . . . The mutation substitutes valine (V) with aspartic acid (D) at residue 31 (residue 299 of unprocessed protein) . . . The FecXI mutation is a non-conservative change in a highly conserved region of the protein	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00000149	Bmp15 Q9Z0L4	Physiology	c.950C>T p.T317I	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00000150	Bmp15 Q9Z0L4	Physiology	c.1009A>C p.N337H	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004) Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]	GP00002155	Bmp15 Q9Z0L4	Physiology	c.718C>T ; p.Q239* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00002156	Bmp15 Q9Z0L4	Physiology	c.G>A p.C321Y missense nonconservative substitution ; in vitro studies showed that the C53Y mutation was responsible for the impairment of the maturation process of the BMP15 protein resulting in a defective secretion of both the precursor and mature peptide	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004) Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]	GP00002157	Bmp15 Q9Z0L4	Physiology	c.1100G>T p.S367I	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Martinez-Royo A; Jurado JJ; Smulders JP ; et al. (2008) A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in R[...] 1 Additional References Monteagudo LV; Ponz R; Tejedor MT (2009) A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolif[...]	GP00002158	Bmp15 Q9Z0L4	Physiology	c.525_541del17 p.Pro45Asnfs*54 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, Insertion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Lassoued N; Benkhlil Z; Woloszyn F ; et al. (2017) FecX a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine [...]	GP00002159	Bmp15 Q9Z0L4	Physiology	C insertion (c.310insC) in the ovine BMP15 cDNA leading to a frame shift at protein position 101 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP3 or PRKG2	Cranio-facial morphology	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Schoenebeck JJ; Hutchinson SA; Byers A ; et al. (2012) Variation of BMP3 contributes to dog breed skull diversity.	GP00000152	Bmp3 Q8BHE5	Morphology	F452L in BMP3 ; this missense mutation is in a conserved position and correlates well with small breeds. However; the functional data (zebrafish BMP3 morpholino knockdown) proposed in this article is inconsistent with the mice BMP3 null-mutation	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		BMP3 or PRKG2	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
BRANCHED1a (BRC1a)	Plant architecture Inflorescence architecture	Coding, SNP	Solanum (genus) D	Intergeneric or Higher	Candidate Gene	Nicolas M; Rodríguez-Buey ML; Franco-Zorrilla JM ; et al. (2015) A Recently Evolved Alternative Splice Site in the BRANCHED1a Gene Controls Potato Plant Architecture[...]	GP00000156	BRC1A F6KB94	Morphology Morphology	Evolution of an alternative splice site (G>A) that unlocks a short isoform	Capsicum annuum (species)	Solanum (genus) D		BRANCHED1a (BRC1a)	Solanum (genus)	Published - Accepted by Curator
Brevis radix (BRX)	Root size (shorter)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Mouchel CF; Briggs GC; Hardtke CS (2004) Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell prolifer[...]	GP00000157	BRX Q17TI5	Morphology	premature stop codon in exon 4; TGG>TGA; truncated protein missing approximately two-thirds of the C terminus N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Brevis radix (BRX)	pH tolerance (acidic soil)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gujas B; Alonso-Blanco C; Hardtke CS (2012) Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil.	GP00001236	BRX Q17TI5	Physiology	K188* (stop codon) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Brevis radix (BRX)	Root growth	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Beuchat J; Li S; Ragni L ; et al. (2010) A hyperactive quantitative trait locus allele of Arabidopsis BRX contributes to natural variation in[...]	GP00001262	BRX Q17TI5	Morphology	21bp deletion at position in spacer 3 (position not given)	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
BTN1A1	Pathogen resistance (virus)	Coding, SNP N	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Elleder D; Stepanets V; Melder DC ; et al. (2005) The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian but[...]	GP00002160	BTN1A1 Q13410	Physiology	g.808011C>A c.165C>A p.C55* N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		BTN1A1	Gallus gallus chicken - (species)	Published - Accepted by Curator
btr1	Seed shattering (grain dispersal ; retention)	Coding, Deletion N	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	Domesticated	Linkage Mapping	Pourkheirandish M; Hensel G; Kilian B ; et al. (2015) Evolution of the Grain Dispersal System in Barley.	GP00001445	BTR1 A0A0K1RJT0	Physiology	1bp deletion at position 202 inducing a frameshift N	Hordeum vulgare (species)	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D		btr1	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies)	Published - Accepted by Curator
btr2	Seed shattering (grain dispersal ; retention)	Coding, Deletion N	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	Domesticated	Linkage Mapping	Pourkheirandish M; Hensel G; Kilian B ; et al. (2015) Evolution of the Grain Dispersal System in Barley.	GP00001446	BTR2 A0A0K1RKV9	Physiology	11bp deletion at position 254-264 creating a frameshift N	Hordeum vulgare (species)	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D		btr2	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies)	Published - Accepted by Curator
BUL2	Telomere length Aging	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Kwan EX; Foss E; Kruglyak L ; et al. (2011) Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and tel[...]	GP00000166	BUL2 Q03758	Physiology Physiology	Leu883Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		BUL2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BvCPSF73-Ia	Bolting time	Coding, Deletion N	Beta vulgaris (species) D	Intraspecific	Linkage Mapping	Tränkner C; Lemnian IM; Emrani N ; et al. (2016) A Detailed Analysis of the BR Locus Suggests a New Mechanism for Bolting after Winter in Sugar Beet [...]	GP00001411	CPSF73-I Q9C952	Physiology	2bp deletion causing a frameshift resulting in a two third truncated protein N	Beta vulgaris (species)	Beta vulgaris (species) D		BvCPSF73-Ia	Beta vulgaris (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, Unknown N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]	GP00000160	BtR Q19KJ3	Physiology	premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		cadherin	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		cadherin	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000164	BtR Q19KJ3	Physiology	24bp in-frame deletion	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, SNP N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Walsh T; James B; Chakroun M ; et al. (2018) Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]	GP00002055	BtR Q19KJ3	Physiology	splice site GT mutated in GA so that splicing does not occur correctly and a 58 bp insertion is found in the cDNA sequence of the cadherin gene. This insertion disrupts the coding sequence in cadherin domain 9 causing a downstream frameshift and a premature stop codon for the rest of the protein. This would result in a truncated protein of 1243 amino acids without the putative binding domain; the membrane anchoring domain; presumably retained inside the cell and not exposed to the Cry1Ac; or alternatively; exported into the gut where it would be degraded N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D		cadherin	Helicoverpa punctigera (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Fabrick JA; Mathew LG; Tabashnik BE (2011) Insertion of an intact CR1 retrotransposon in a cadherin gene linked with Bt resistance in the pink [...]	GP00002449	A0A1B0RHM4	Physiology	insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon designated CR1-1_Pg. Unlike most other CR1 elements CR1-1_Pg is intact and transcribed by a flanking promoter. It contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002450	A0A1B0RHM4	Physiology	24-bp deletion in putative exon 21 causing the loss of eight amino acid residues N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002451	A0A1B0RHM4	Physiology	126-bp deletion spanning a putative intron 15/exon 16 splice site that introduces a premature stop codon and causes loss of the final 929 amino acid residues. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D		cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion	Ostrinia furnacalis Asian corn borer - (species) D	Intraspecific	Candidate Gene	Jin T; Chang X; Gatehouse AM ; et al. (2014) Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...] 1 Additional References Jurat-Fuentes JL; Heckel DG; Ferré J (2021) Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis.	GP00002464	A0A1B0RHM4	Physiology	MPR-r2 has a 26-amino acid residue deletion in the TBR which results in reduced binding of Cry1Ac compared to the MPR from the susceptible strain.	Ostrinia furnacalis Asian corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species) D		cadherin	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP	Ostrinia furnacalis Asian corn borer - (species) D	Intraspecific	Candidate Gene	Jin T; Chang X; Gatehouse AM ; et al. (2014) Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...] 1 Additional References Jurat-Fuentes JL; Heckel DG; Ferré J (2021) Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis.	GP00002465	A0A1B0RHM4	Physiology	Thr1457Ser	Ostrinia furnacalis Asian corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species) D		cadherin	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
cardinal	Coloration (eyes)	Coding, Insertion N	Tribolium castaneum red flour beetle - (species) D	Domesticated	Candidate Gene	Shirai Y; Daimon T (2020) Mutations in cardinal are responsible for the red-1 and peach eye color mutants of the red flour bee[...]	GP00002665	cd Q9VCW2	Morphology	A fragment of a transposable element (about 5 kb - 99% identical in amino acids to a putative retrotransposon (XP_015838217)) is inserted into exon 6. This insertion introduced a premature stop codon just after the insertion site. Amino acid residues near the C-terminal end of the haem peroxidase domain are thus disrupted. N	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species) D		cardinal	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
cardinal	Coloration (eyes)	Coding, Deletion N	Tribolium castaneum red flour beetle - (species) D	Domesticated	Candidate Gene	Shirai Y; Daimon T (2020) Mutations in cardinal are responsible for the red-1 and peach eye color mutants of the red flour bee[...]	GP00002666	cd Q9VCW2	Morphology	1-bp deletion in exon 6 that causes a frameshift mutation. Amino acid residues near the C-terminal end of the haem peroxidase domain are thus disrupted. N	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species) D		cardinal	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
cardinal	Coloration (eyes)	Coding, SNP N	Bombyx mori domestic silkworm - (species) D	Domesticated	Candidate Gene	Osanai-Futahashi M; Tatematsu KI; Futahashi R ; et al. (2016) Positional cloning of a Bombyx pink-eyed white egg locus reveals the major role of cardinal in ommoc[...]	GP00002667	cd Q9VCW2	Morphology	Missense mutation in a conserved motif in exon 9. The tryptophan residue which is converted to arginine in the two pe strains is widely conserved in holometabolous insects. N	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D		cardinal	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
Catecholamines up	Bristle number Lifespan Locomotor activity Sleep	Coding, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Carbone MA; Jordan KW; Lyman RF ; et al. (2006) Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Droso[...] 1 Additional References Stein MB; Koverola C; Hanna C (1997) Hippocampal volume in women victimized by childhood sexual abuse.	GP00000172	Catsup Q9V3A4	Morphology Physiology Behavior Behavior	unknown; but most large-effect variants appear to be coding	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Catecholamines up	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cathepsin E	Digestion (absence of stomach)	2 Mutations: Coding N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001910	CTSE P14091	Physiology	2 mutations	Monodelphis domestica gray short-tailed opossum - (species) Homo sapiens human - (species)	Ornithorhynchus anatinus platypus - (species) D		cathepsin E	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
Cauliflower (BoCAL)	Inflorescence morphology	Coding, SNP N	Brassica oleracea var. botrytis (varietas) D	Domesticated	Candidate Gene	Kempin SA; Savidge B; Yanofsky MF (1995) Molecular basis of the cauliflower phenotype in Arabidopsis. 1 Additional References Purugganan MD; Boyles AL; Suddith JI (2000) Variation and selection at the CAULIFLOWER floral homeotic gene accompanying the evolution of domest[...]	GP00000173	CAL Q39081	Morphology	GAG>TAG; E151*; protein truncated after only 150 of the 255 amino acids of the wild-type protein N	Brassica oleracea wild cabbage - (species)	Brassica oleracea var. botrytis (varietas) D		Cauliflower (BoCAL)	Brassica oleracea var. botrytis (varietas)	Published - Accepted by Curator
CBF12	Temperature tolerance (cold)	Coding, Unknown	Triticum monococcum (species)	Domesticated	Linkage Mapping	Knox AK; Li C; Vágújfalvi A ; et al. (2008) Identification of candidate CBF genes for the frost tolerance locus Fr-Am2 in Triticum monococcum.	GP00000175	B1NSN2	Physiology	possibly 5a.a. deletion in DNA binding domain	Triticum monococcum (species)	Triticum monococcum (species)		CBF12	Triticum monococcum (species)	Published - Accepted by Curator
CDKN2A	Coloration (feathers ; sex-linked dilution)	2 Mutations:	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Schwochow Thalmann D; Ring H; Sundström E ; et al. (2017) The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes [...] 1 Additional References Hellström AR; Sundström E; Gunnarsson U (2010) Sex-linked barring in chickens is controlled by the CDKN2A /B tumour suppressor locus.	GP00000178	CDKN2A P42771	Morphology	2 mutations	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		CDKN2A	Gallus gallus chicken - (species)	Published - Accepted by Curator
CDKN2A	Coloration (feathers ; sex-linked barring)	2 Mutations:	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Schwochow Thalmann D; Ring H; Sundström E ; et al. (2017) The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes [...] 1 Additional References Hellström AR; Sundström E; Gunnarsson U (2010) Sex-linked barring in chickens is controlled by the CDKN2A /B tumour suppressor locus.	GP00002162	CDKN2A P42771	Morphology	2 mutations	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		CDKN2A	Gallus gallus chicken - (species)	Published - Accepted by Curator
CENTRORADIALIS (HvCEN)	Flowering time Seasonal growth	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Comadran J; Kilian B; Russell J ; et al. (2012) Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and [...]	GP00000179	CEN Q9ZNV5	Physiology Physiology	P135A	Hordeum vulgare (species)	Hordeum vulgare (species)		CENTRORADIALIS (HvCEN)	Hordeum vulgare (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide ; benzoylurea)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Douris V; Steinbach D; Panteleri R ; et al. (2016) Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]	GP00001600	CHS1 A3KCN0	Physiology	T>G p.I1042M (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		Chitin synthase 1 (CHS1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; benzoylurea)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Douris V; Steinbach D; Panteleri R ; et al. (2016) Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]	GP00001601	CHS1 A3KCN0	Physiology	A>T p.I1042F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		Chitin synthase 1 (CHS1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; etoxazole acaricide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species)	Intraspecific	Linkage Mapping	Demaeght P; Osborne EJ; Odman-Naresh J ; et al. (2014) High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally di[...] 1 Additional References Van Leeuwen T; Demaeght P; Osborne EJ (2012) Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin s[...]	GP00001602	chs1 H9U0G2	Physiology	A>T p.I1017F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species)		Chitin synthase 1 (CHS1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; benzoylurea)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Suzuki Y; Shiotsuki T; Jouraku A ; et al. (2017) Benzoylurea resistance in western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae)[...]	GP00002628	CHS1 A3KCN0	Physiology	isoleucine to methionine	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		Chitin synthase 1 (CHS1)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
CHKov1	Pathogen resistance Xenobiotic resistance (insecticide)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Magwire MM; Bayer F; Webster CL ; et al. (2011) Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...] 1 Additional References Aminetzach YT; Macpherson JM; Petrov DA (2005) Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila.	GP00000182	CHKov1 Q961V7	Physiology Physiology	Insertion of a Doc TE element resulting in novel; seemingly functional short protein	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		CHKov1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
chloroquine resistance transporter	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001533	CRT Q9N623	Physiology	p.Ile356Thr	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		chloroquine resistance transporter	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
chordin	Fin morphology (skeleton; dorsal fin; caudal fin; tail; paired fin)	Coding, SNP N	Carassius auratus goldfish - (species) D	Domesticated	Candidate Gene	Abe G; Lee SH; Chang M ; et al. (2014) The origin of the bifurcated axial skeletal system in the twin-tail goldfish. 1 Additional References Kon T; Omori Y; Fukuta K (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002346	chdA W8VTE1	Morphology	stop codon in codon 127. GAG (E) -> TAG (STOP). Predicted to result in a truncated protein lacking the second to fourth CR domains. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D		chordin	Carassius auratus goldfish - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Erinaceus concolor southern white-breasted hedgehog - (species) D Erinaceus europaeus western European hedgehog - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00000183	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Erinaceus concolor southern white-breasted hedgehog - (species) D Erinaceus europaeus western European hedgehog - (species) D		CHRNA1	Erinaceus concolor southern white-breasted hedgehog - (species) Erinaceus europaeus western European hedgehog - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Mellivora capensis ratel - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00000184	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Mellivora capensis ratel - (species) D		CHRNA1	Mellivora capensis ratel - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	4 Mutations: Coding SNP	Herpestes ichneumon Egyptian mongoose - (species) D	Intergeneric or Higher	Candidate Gene	Barchan D; Kachalsky S; Neumann D ; et al. (1992) How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. 2 Additional References Kachalsky SG; Jensen BS; Barchan D (1995) Two subsites in the binding domain of the acetylcholine receptor: an aromatic subsite and a proline [...] Barchan D; Kachalsky S; Neumann D (1992) How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.	GP00001686	CHRNA1 P02708	Physiology	4 mutations	Carnivora carnivores - (order)	Herpestes ichneumon Egyptian mongoose - (species) D		CHRNA1	Herpestes ichneumon Egyptian mongoose - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	Coding, SNP	Naja haje (species) D	Intergeneric or Higher	Candidate Gene	Takacs Z; Wilhelmsen KC; Sorota S (2004) Cobra ( Naja spp. ) nicotinic acetylcholine receptor exhibits resistance to Erabu sea snake ( Latica[...]	GP00001720	CHRNA1 P02708	Physiology	Phe189Asn - The inhibitory effect on the pharmacological action of the toxin is primarily attributed to the presence of glycosylation at position N189.	Carnivora carnivores - (order)	Naja haje (species) D		CHRNA1	Naja haje (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Sus scrofa pig - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00001721	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Sus scrofa pig - (species) D		CHRNA1	Sus scrofa pig - (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	3 Mutations: N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001391	CNL A0A172W603	Physiology	3 mutations	Petunia axillaris (species)	Petunia exserta (species) D		Cinnamate-CoA ligase 1 (CNL1)	Petunia exserta (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, SNP N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001767	CNL A0A172W603	Physiology	serine-to-arginine exchange at position 453 (T-to-A nucleotide exchange at genomic position 7 539 424) - this mutation is located immediately next to highly conserved amino acids predicted to be involved in adenosine monophosphate and coenzyme A binding; it involves two biochemically very dissimilar amino acids; and the serine at this position is conserved N	Capsella grandiflora (species)	Capsella rubella (species) D		Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, Deletion N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001768	CNL A0A172W603	Physiology	a 4 bp deletion resulting in a frameshift 795 bp downstream of the start codon and causing a premature stop codon N	Capsella grandiflora (species)	Capsella rubella (species) D		Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
CINNAMOYL CO-A REDUCTASE 1	Fiber content	Coding, Unknown N	Brassica napus rape - (species)	Domesticated	Linkage Mapping	Liu L; Stein A; Wittkop B ; et al. (2012) A knockout mutation in the lignin biosynthesis gene CCR1 explains a major QTL for acid detergent lig[...]	GP00000186	CCR1 Q9S9N9	Physiology	Frameshift mutation in exon1 N	Brassica napus rape - (species)	Brassica napus rape - (species)		CINNAMOYL CO-A REDUCTASE 1	Brassica napus rape - (species)	Published - Accepted by Curator
CmACS-7	Flower sex determination (male organs)	Coding, SNP	Cucumis melo muskmelon - (species)	Domesticated	Linkage Mapping	Boualem A; Fergany M; Fernandez R ; et al. (2008) A conserved mutation in an ethylene biosynthesis enzyme leads to andromonoecy in melons.	GP00000187	ACS7 Q9STR4	Physiology	A57V	Cucumis melo muskmelon - (species)	Cucumis melo muskmelon - (species)		CmACS-7	Cucumis melo muskmelon - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 1 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.	GP00002163	Cmah Q61419	Physiology	c.179G>T p.G60V	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 1 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.	GP00002164	Cmah Q61419	Physiology	c.364C>T p.P122S	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, Deletion N	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Kehl A; Heimberger K; Langbein-Detsch I (2018) Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping sch[...]	GP00002165	Cmah Q61419	Physiology	c.1322delT p.Leu441* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002166	Cmah Q61419	Physiology	c.139G>A p.V47M	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002167	Cmah Q61419	Physiology	c.268T>A p.Y89N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002168	Cmah Q61419	Physiology	c.1600G>A p.D534N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CNL9 (=Sr35)	Pathogen resistance	Coding, Complex Change	Triticum monococcum (species)	Domesticated	Linkage Mapping	Saintenac C; Zhang W; Salcedo A ; et al. (2013) Identification of wheat gene Sr35 that confers resistance to Ug99 stem rust race group.	GP00000189	Sr35 S5ABD6	Physiology	Coding variation in the LRR domain - a spontaneous gene conversion between CNL4 and CNL9 is the most parsimonious explanation for the three linked mutations in CNL9	Triticum monococcum (species)	Triticum monococcum (species)		CNL9 (=Sr35)	Triticum monococcum (species)	Published - Accepted by Curator
coatomer protein complex subunit alpha (COPA)	Coloration (coat)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Dorshorst B; Henegar C; Liao X ; et al. (2015) Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Pr[...]	GP00001329	COPA P53621	Morphology	c.C>T p.Arg160Cys	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		coatomer protein complex subunit alpha (COPA)	Bos taurus cattle - (species)	Published - Accepted by Curator
CORIN	Coloration (coat)	Coding, SNP	Panthera tigris tiger - (species) D	Intraspecific	Linkage Mapping	Xu X; Dong GX; Schmidt-Küntzel A ; et al. (2017) The genetics of tiger pelage color variations.	GP00002169	Corin Q9Z319	Morphology	c.1759C >T p.H587Y	Panthera tigris tiger - (species)	Panthera tigris tiger - (species) D		CORIN	Panthera tigris tiger - (species)	Published - Accepted by Curator
Couch potato	Diapause	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Schmidt PS; Zhu CT; Das J ; et al. (2008) An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]	GP00000191	cpo Q01617	Physiology	Ile462Lys	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Couch potato	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
COX18	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001708	COX18 P53239	Physiology	Leu59His (T>A at position 617107 according to Table 1) - CTY to CAY position 617107	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		COX18	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, SNP N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002102	Q95WY5	Physiology	Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin. N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Insertion N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002103	Q95WY5	Physiology	Insertion of a 451-bpTE into the exon 2 of the toxin receptor gene. The insertion induces a new mRNA splicing event that creates a shorter transcript. This new transcript encodes an altered receptor unable to interact with the toxin resulting in resistance to this insecticide. The missing portion includes GPI-anchoring signals N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Deletion N	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Guo QY; Cai QX; Yan JP ; et al. (2013) Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaeri[...] 1 Additional References Darboux I; Pauchet Y; Castella C (2002) Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.	GP00002552	Q95WY5	Physiology	one-nucleotide deletion which results in a premature stop codon and leads to production of a truncated protein. N	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		Cpm1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
CREBRF	Body size (obesity)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Minster RL; Hawley NL; Su CT ; et al. (2016) A thrifty variant in CREBRF strongly influences body mass index in Samoans.	GP00001444	CREBRF Q8IUR6	Morphology	c.1370G>A p.Arg457Gln	Homo sapiens human - (species)	Homo sapiens human - (species) D		CREBRF	Homo sapiens human - (species)	Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele	Flowering time Fruit shape (fruit length) Flower morphology (ovule number per fruit) Fertility (percentage of unfertilized ovules)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001) A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2. 3 Additional References Olsen KM; Halldorsdottir SS; Stinchcombe JR (2004) Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. el-Assal SE; Alonso-Blanco C; Hanhart CJ (2004) Pleiotropic effects of the Arabidopsis cryptochrome 2 allelic variation underlie fruit trait-related[...] Botto JF; Alonso-Blanco C; Garzarón I (2003) The Cape Verde Islands allele of cryptochrome 2 enhances cotyledon unfolding in the absence of blue [...]	GP00000192	CRY2 Q96524	Physiology Morphology Morphology Physiology	V367M	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Cryptochrome 2 (CRY2) EDI allele	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CXCL16	Pathogen resistance (lymphocyte susceptibility to virus)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Association Mapping	Sarkar S; Bailey E; Go YY ; et al. (2016) Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus In[...]	GP00001591	CXCL16 F7CTX0	Physiology	4 candidate nonsynonymous substitutions within exon 1(in 2 susceptible variants): (1)c.715A>T p.Tyr40Phe (2)c.801G>C w.Asp49His (3)c.804T>A/G p.Phe50Ile (4)c.810G>A p.Glu52Lys	Equus caballus horse - (species)	Equus caballus horse - (species)		CXCL16	Equus caballus horse - (species)	Published - Accepted by Curator
CYC8	Salt tolerance (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000195	CYC8 P14922	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		CYC8	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CYP(T)	Flower morphology (style length)	Coding, Insertion N	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001394	CYP734A1 O48786	Morphology	single base insertion in exon 2 introduces a disruptive premature stop codon N	Primula vulgaris (species)	Primula vulgaris (species) D		CYP(T)	Primula vulgaris (species)	Published - Accepted by Curator
CYP(T)	Flower morphology (style length)	Coding, SNP	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001395	CYP734A1 O48786	Morphology	G>C p.Asp126His in exon 2	Primula vulgaris (species)	Primula vulgaris (species) D		CYP(T)	Primula vulgaris (species)	Published - Accepted by Curator
CYP1A2	Enzymatic activity	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Murayama N; Soyama A; Saito Y ; et al. (2004) Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]	GP00000199	CYP1A2 P05177	Physiology	F186L	Homo sapiens human - (species)	Homo sapiens human - (species) D		CYP1A2	Homo sapiens human - (species)	Published - Accepted by Curator
Cyp28d1	Xenobiotic resistance (nicotine ; larval stage)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002113	Cyp28d1 Q9VMT5	Physiology	insertion of a FW element (4720 bp) into the coding region (exon) of the second copy of the Cyp28d1 (there is still another copy of the gene left due to a duplication). Associated with a decrease in Cyp28d2 gene expression and a decrease in nicotin resistance.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Cyp28d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP2C9	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000200	CYP2C9 P11712	Physiology	I359L	Homo sapiens human - (species)	Homo sapiens human - (species)		CYP2C9	Homo sapiens human - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Association Mapping	Joußen N; Agnolet S; Lorenz S ; et al. (2012) Resistance of Australian Helicoverpa armigera to fenvalerate is due to the chimeric P450 enzyme CYP3[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002477	CYP337B3 A0A0H3V333	Physiology	The unique P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The exclusive presence of CYP337B3 in resistant insects of this strain confers a 42-fold resistance to fenvalerate.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Rasool Akhtar; Joußen Nicole; Lorenz Sybille ; et al. (2014 ) An independent occurrence of the chimeric P450 enzyme CYP337B3 of Helicoverpa armigera confers cyper[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002478	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The Pakistani and the Australian CYP337B3 alleles differ by 18 synonymous and three nonsynonymous SNPs and additionally in the length and sequence of the intron.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002479	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002480	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002481	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002482	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002483	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002484	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Insertion	Helicoverpa zea corn earworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...] 1 Additional References Valencia-Montoya WA; Elfekih S; North HL (2020) Adaptive Introgression across Semipermeable Species Boundaries between Local Helicoverpa zea and Inv[...]	GP00002485	CYP337B3 A0A0H3V333	Physiology	Introgression of the CYP337B3v2 resistant allele from Helicoverpa armigera	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		CYP337B3	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
CYP392A16	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Papapostolou KM; Riga M; Samantsidis GR (2022) Over-expression in cis of the midgut P450 CYP392A16 contributes to abamectin resistance in Tetranych[...]	GP00002471	Ace P07140	Physiology	several non-synonymous SNP - exact causing amino acid change(s) unknown. Functional analysis of the putative promoter region from the resistant and susceptible parental strains revealed a higher reporter gene expression confirming the presence of cis-acting regulatory mechanisms.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		CYP392A16	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CYP4F2	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000203	CYP4F2 P78329	Physiology	V433M	Homo sapiens human - (species)	Homo sapiens human - (species)		CYP4F2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP6AB3	Xenobiotic resistance (imperatorin)	Coding, SNP	Depressaria pastinacella (species)	Intraspecific	Candidate Gene	Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007) Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]	GP00000204	CYP6AB3 Q7YZS3	Physiology	Ala92Val (and potentiallly 4 other a.a. substitutions)	Depressaria pastinacella (species)	Depressaria pastinacella (species)		CYP6AB3	Depressaria pastinacella (species)	Published - Accepted by Curator
CYP6B1	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio polyxenes black swallowtail - (species)	Interspecific	Candidate Gene	Li W; Schuler MA; Berenbaum MR (2003) Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Sp[...]	GP00000205	CYP6B1 Q04552	Physiology Physiology	Ile484Phe and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio polyxenes black swallowtail - (species)		CYP6B1	Papilio polyxenes black swallowtail - (species)	Published - Accepted by Curator
CYP6B4	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio glaucus eastern tiger swallowtail - (species)	Intergeneric or Higher	Candidate Gene	Mao W; Schuler MA; Berenbaum MR (2007) Cytochrome P450s in Papilio multicaudatus and the transition from oligophagy to polyphagy in the Pap[...]	GP00000206	CYP6B4 Q27902	Physiology Physiology	Lys484Ser and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio glaucus eastern tiger swallowtail - (species)		CYP6B4	Papilio glaucus eastern tiger swallowtail - (species)	Published - Accepted by Curator
cyp6d2	Xenobiotic resistance (chemotherapeutic agent, camptothecin)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Thomas AM; Hui C; South A ; et al. (2013) Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]	GP00001983	Cyp6g2 Q9V675	Physiology	G>C in CATAGgtaagga...caagCTCT so that intron 3 is not spliced and the codon GCT (spanning the intron) is transformed into CCT. The splicing is defective and intron 3 is transcribed and results in a stop codon and a protein truncated from its native C terminal part.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		cyp6d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6d2	Xenobiotic resistance (chemotherapeutic agent, camptothecin)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Thomas AM; Hui C; South A ; et al. (2013) Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]	GP00001984	Cyp6g2 Q9V675	Physiology	N438T (A22652974C) and N439T (A22652978G) - exact causing mutation(s) not identified - semiquantitative RT-PCR revealed that this mutant produces little to no Cyp6d2 transcript. The mutation is thus also cis-regulatory.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		cyp6d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002472	cyp6er1 A0A2I8B6P1	Physiology	T318S substitution results in a marked (20-fold) and significant increase in resistance compared to the wild-type susceptible variant.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, Deletion	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002473	cyp6er1 A0A2I8B6P1	Physiology	Deletion of Pro377. This provides a more moderate but significant 4.5-fold increase in resistance.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, Complex Change	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002474	cyp6er1 A0A2I8B6P1	Physiology	A375del+A376G	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D		CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6P9; CYP6P4 cluster	Xenobiotic resistance (insecticide)	5 Mutations:	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Wondji CS; Irving H; Morgan J ; et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...] 2 Additional References Weedall GD; Mugenzi LMJ; Menze BD (2019) A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing i[...] Wondji CS; Hearn J; Irving H (2022) RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ h[...]	GP00000209	Q2YH43	Physiology	5 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D		CYP6P9; CYP6P4 cluster	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP76AD1	Coloration	Coding, Insertion N	Beta vulgaris (species) D	Domesticated	Linkage Mapping	Hatlestad GJ; Sunnadeniya RM; Akhavan NA ; et al. (2012) The beet R locus encodes a new cytochrome P450 required for red betalain production.	GP00000210	CYP76AD1 I3PFJ5	Morphology	5bp insertion resulting in frameshift N	Beta vulgaris (species)	Beta vulgaris (species) D		CYP76AD1	Beta vulgaris (species)	Published - Accepted by Curator
CYP9A186	Xenobiotic resistance (insecticide; avermectin; emamectin benzoate; abamectin)	Coding, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Zuo Y; Shi Y; Zhang F ; et al. (2021) Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in[...]	GP00002393	CYP9A186 A0A8E4AAI2	Physiology	Heterologous expression and in vitro functional assays further confirm that a natural substitution (F116V) found in the substrate recognition site 1 (SRS1) of the CYP9A186 protein results in enhanced metabolism of EB and abamectin	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		CYP9A186	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)	Coding, SNP	Plasmopara viticola (species) D	Intraspecific	Candidate Gene	Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007) At least two origins of fungicide resistance in grapevine downy mildew populations.	GP00002041	UQCRFS1 P47985	Physiology	Gly143Ala G1256C	Plasmopara viticola (species)	Plasmopara viticola (species) D		cytochrome b	Plasmopara viticola (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)	Coding, SNP	Plasmopara viticola (species) D	Intraspecific	Candidate Gene	Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007) At least two origins of fungicide resistance in grapevine downy mildew populations.	GP00002042	UQCRFS1 P47985	Physiology	Gly143Ala G1256C	Plasmopara viticola (species)	Plasmopara viticola (species) D		cytochrome b	Plasmopara viticola (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; myxothiazol)	Coding, SNP	Chlamydomonas reinhardtii (species) D	Intraspecific	Candidate Gene	Bennoun P; Delosme M; Kück U (1991) Mitochondrial genetics of Chlamydomonas reinhardtii: resistance mutations marking the cytochrome b g[...]	GP00002043	UQCRFS1 P47985	Physiology	F129L	Chlamydomonas reinhardtii (species)	Chlamydomonas reinhardtii (species) D		cytochrome b	Chlamydomonas reinhardtii (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	2 Mutations: Coding SNP	Mycena galopus (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002044	UQCRFS1 P47985	Physiology	2 mutations	Mycena viridimarginata (species)	Mycena galopus (species) D		cytochrome b	Mycena galopus (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	2 Mutations: Coding SNP	Strobilurus tenacellus (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002045	UQCRFS1 P47985	Physiology	2 mutations	Mycena viridimarginata (species)	Strobilurus tenacellus (species) D		cytochrome b	Strobilurus tenacellus (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	Coding, SNP	Schizosaccharomyces pombe fission yeast - (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002046	UQCRFS1 P47985	Physiology	N261D	Saccharomyces cerevisiae baker's yeast - (species)	Schizosaccharomyces pombe fission yeast - (species) D		cytochrome b	Schizosaccharomyces pombe fission yeast - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (insecticide ; bifenazate)	2 Mutations: Coding SNP	Tetranychus urticae two-spotted spider mite - (species) D	Interspecific	Candidate Gene	Van Leeuwen T; Vanholme B; Van Pottelberge S ; et al. (2008) Mitochondrial heteroplasmy and the evolution of insecticide resistance: non-Mendelian inheritance in[...]	GP00002599	UQCRFS1 P47985	Physiology	2 mutations	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		cytochrome b	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (insecticide ; bifenazate)	2 Mutations: Coding SNP	Panonychus citri citrus red mite - (species) D	Interspecific	Candidate Gene	Van Leeuwen T; Van Nieuwenhuyse P; Vanholme B ; et al. (2011) Parallel evolution of cytochrome b mediated bifenazate resistance in the citrus red mite Panonychus [...]	GP00002600	UQCRFS1 P47985	Physiology	2 mutations	Panonychus citri citrus red mite - (species)	Panonychus citri citrus red mite - (species) D		cytochrome b	Panonychus citri citrus red mite - (species)	Published - Accepted by Curator
cytochrome c oxidase (COX7A)	Fertility Lifespan Locomotor activity	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Melvin RG; Katewa SD; Ballard JW (2008) A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...] 1 Additional References Ballard JW; Melvin RG (2011) Early life benefits and later life costs of a two amino acid deletion in Drosophila simulans.	GP00001980	COX7A Q9VHS2	Physiology Physiology Physiology	Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.	Drosophila simulans (species)	Drosophila simulans (species) D		cytochrome c oxidase (COX7A)	Drosophila simulans (species)	Published - Accepted by Curator
D14 (KAI2 paralog)	Seed dormancy (strigolactone responsiveness)	Coding, Unknown	Arabidopsis thaliana thale cress - (species) D	Intergeneric or Higher	Candidate Gene	Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015) PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]	GP00000213	D14 Q10QA5	Physiology	Ligand-binding pocket tuning	Spermatophyta (no rank)	Arabidopsis thaliana thale cress - (species) D		D14 (KAI2 paralog)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
DCAR-032551	Carotenoid content	Coding, Insertion N	Daucus carota carrot - (species) D	Domesticated	Linkage Mapping	Iorizzo M; Ellison S; Senalik D ; et al. (2016) A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid[...]	GP00001568	DCAR_032551 A0A162A3G8	Morphology	A 212-nt insertion in exon 2 that creates a frameshift mutation N	Daucus carota carrot - (species)	Daucus carota carrot - (species) D		DCAR-032551	Daucus carota carrot - (species)	Published - Accepted by Curator
DEEPER ROOTING 1	Drought tolerance Root growth	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Uga Y; Sugimoto K; Ogawa S ; et al. (2013) Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought condition[...]	GP00000215	Dro1 Q69P88	Physiology Morphology	1bp deletion within exon 4 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		DEEPER ROOTING 1	Oryza sativa rice - (species)	Published - Accepted by Curator
Delta-1-pyrroline-5-carboxylate synthase A	Drought response (drought-induced proline accumulation)	2 Mutations: Coding	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kesari R; Lasky JR; Villamor JG ; et al. (2012) Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation[...]	GP00001280	P5CSA P54887	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Delta-1-pyrroline-5-carboxylate synthase A	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
dentin sialophosphoprotein (DSPP)	Tooth absence (no enamel production)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001936	DSPP Q9NZW4	Physiology	synteny of the corresponding region - only the N-terminal region of DSPP is present in the genome - 1-bp deletion in exon one leading to a reading frame shift were this sequence to be translated N	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D		dentin sialophosphoprotein (DSPP)	Gallus gallus chicken - (species)	Published - Accepted by Curator
DEP1	Grain yield	Coding, Indel N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Huang X; Qian Q; Liu Z ; et al. (2009) Natural variation at the DEP1 locus enhances grain yield in rice.	GP00000218	P0046G12.12-1 Q67UU9	Morphology	replacement of a 637bp stretch of the middle of exon5 by a 12-bp sequence creating a premature stop codon and consequently a loss of 230 residues from the C-terminus N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		DEP1	Oryza sativa rice - (species)	Published - Accepted by Curator
DEP1 (DENSE AND ERECT PANICLES 1)	Nitrogen use (metabolism)	Coding, SNP	Oryza sativa Japonica Group Japanese rice - (no rank)	Domesticated	Linkage Mapping	Sun H; Qian Q; Wu K ; et al. (2014) Heterotrimeric G proteins regulate nitrogen-use efficiency in rice.	GP00001376	P0046G12.12-1 Q67UU9	Physiology	p.Cys105Tyr affecting affinity interaction between the GGL domain of DEP1 and RGB1 subunit	Oryza sativa Indica Group long-grained rice - (no rank)	Oryza sativa Japonica Group Japanese rice - (no rank)		DEP1 (DENSE AND ERECT PANICLES 1)	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
diacylglycerol acyltransferase 1 (DGAT1)	Milk fat content	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Grisart B; Coppieters W; Farnir F ; et al. (2002) Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the [...] 1 Additional References Grisart B; Farnir F; Karim L (2004) Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotid[...]	GP00000222	Dgat1 Q9Z2A7	Physiology	K232A	Bos taurus cattle - (species)	Bos taurus cattle - (species)		diacylglycerol acyltransferase 1 (DGAT1)	Bos taurus cattle - (species)	Published - Accepted by Curator
diacylglycerol acyltransferase 1-2 (DGAT1-2)	Oil composition Oil yield	Coding, Deletion	Zea mays (species) D	Domesticated	Linkage Mapping	Zheng P; Allen WB; Roesler K ; et al. (2008) A phenylalanine in DGAT is a key determinant of oil content and composition in maize.	GP00000223	DGAT1-2 B0LF77	Physiology Physiology	Deletion of amino acid F469	Zea mays (species)	Zea mays (species) D		diacylglycerol acyltransferase 1-2 (DGAT1-2)	Zea mays (species)	Published - Accepted by Curator
Dihydroflavonol 4 reductase (MlDfr)	Coloration (flower)	Coding, Insertion N	Erythranthe lewisii (species) D	Intraspecific	Candidate Gene	Wu CA; Streisfeld MA; Nutter LI ; et al. (2013) The genetic basis of a rare flower color polymorphism in Mimulus lewisii provides insight into the r[...]	GP00001457	DFRA P51102	Morphology	A 2 nt (TG) insertion at position 265 causing a frameshift and a greatly truncated protein of 106 aa only about one-fourth of its functional length N	Erythranthe lewisii (species)	Erythranthe lewisii (species) D		Dihydroflavonol 4 reductase (MlDfr)	Erythranthe lewisii (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (flowers)	Coding, Deletion	Iochroma calycinum (species) D	Intraspecific	Candidate Gene	Coburn RA; Griffin RH; Smith SD (2015) Genetic basis for a rare floral mutant in an Andean species of Solanaceae.	GP00000224	DFRA P51102	Morphology	33bp (11 a.a) deletion In coding sequence	Iochroma calycinum (species)	Iochroma calycinum (species) D		dihydroflavonol reductase (DFR)	Iochroma calycinum (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (flowers)	Coding, SNP	Iochroma cyaneum (species)	Intraspecific	Linkage Mapping	Smith SD; Rausher MD (2011) Gene loss and parallel evolution contribute to species difference in flower color.	GP00000225	DFRA P51102	Morphology	12 candidate a.a. substitution in cluding one at a residue known to influence substrate specificity	Iochroma cyaneum (species)	Iochroma cyaneum (species)		dihydroflavonol reductase (DFR)	Iochroma cyaneum (species)	Published - Accepted by Curator
dihydroflavonol reductase (DFR)	Coloration (tuber skin)	Coding, Unknown	Solanum tuberosum potato - (species)	Domesticated	Linkage Mapping	De Jong WS; De Jong DM; De Jong H ; et al. (2003) An allele of dihydroflavonol 4-reductase associated with the ability to produce red anthocyanin pigm[...] 1 Additional References Zhang Y; Cheng S; De Jong D (2009) The potato R locus codes for dihydroflavonol 4-reductase.	GP00000226	DFRA P51102	Morphology	unknown; 10 a.a variable positions	Solanum tuberosum potato - (species)	Solanum tuberosum potato - (species)		dihydroflavonol reductase (DFR)	Solanum tuberosum potato - (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Unckless RL; Rottschaefer SM; Lazzaro BP (2015) The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster. 1 Additional References Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.	GP00000227	DptA P24492	Physiology	Ser>Arg (AGC>AGA)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Diptericin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Diptericin	Pathogen resistance (bacteria)	Coding, SNP	Drosophila simulans (species)	Intraspecific	Candidate Gene	Unckless RL; Howick VM; Lazzaro BP (2016) Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila. 1 Additional References Unckless RL; Lazzaro BP (2016) The potential for adaptive maintenance of diversity in insect antimicrobial peptides.	GP00000228	DptA P24492	Physiology	Ser>Arg (AGC>AGG)	Drosophila simulans (species)	Drosophila simulans (species)		Diptericin	Drosophila simulans (species)	Published - Accepted by Curator
Distorter on the X (Dox)	Sex determination (sex ratio distortion)	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Tao Y; Araripe L; Kingan SB ; et al. (2007) A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.	GP00001969		Physiology	Deletion of 105bp, resulting in the loss of exon III, which deletes one of the 42bp elements that is tandemly repeated in wild-type Dsim\Dox.	Drosophila simulans (species)	Drosophila simulans (species) D		Distorter on the X (Dox)	Drosophila simulans (species)	Published - Accepted by Curator
DMRT3	Gait (ability to pace)	Coding, SNP N	Equus caballus horse - (species)	Domesticated	Linkage Mapping	Andersson LS; Larhammar M; Memic F ; et al. (2012) Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. 1 Additional References Petersen JL; Mickelson JR; Rendahl AK (2013) Genome-wide analysis reveals selection for important traits in domestic horse breeds.	GP00000230	DMRT3 F6W2R2	Behavior	g.22999655C>A p.S301* Premature stop codon (Ser301Stop) resulting in truncated protein: a single base change at nucleotide position chr23:22999655 causing a premature stop at codon 301 in DMRT3 (DMRT3_Ser301STOP). The allele is expected to encode a truncated protein lacking 1 N	Equus caballus horse - (species)	Equus caballus horse - (species)		DMRT3	Equus caballus horse - (species)	Published - Accepted by Curator
DNA replication factor CDT1	Resistance to UV irradiation	Coding, SNP	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001507	CDT1 Q9H211	Physiology	p.Ala537Val	Rhinopithecus avunculus Tonkin snub-nosed monkey - (species)	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D		DNA replication factor CDT1	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) Rhinopithecus bieti black snub-nosed monkey - (species)	Published - Accepted by Curator
DNA replication factor CDT1 [[likely pseudo-replicate of other CDT1 entry by introgression]]	Resistance to UV irradiation	Coding, SNP	Rhinopithecus roxellana golden snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001508	CDT1 Q9H211	Physiology	p.Ala537Val	Rhinopithecus brelichi Gray snub-nosed monkey - (species)	Rhinopithecus roxellana golden snub-nosed monkey - (species) D		DNA replication factor CDT1 [[likely pseudo-replicate of other CDT1 entry by introgression]]	Rhinopithecus roxellana golden snub-nosed monkey - (species)	Published - Accepted by Curator
drh-1	Pathogen resistance (viral immunity)	Coding, Deletion	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Ashe A; Bélicard T; Le Pen J ; et al. (2013) A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and an[...]	GP00001308	drh-1 G5EDI8	Physiology	159 base deletion in CDS resulting in truncated but potentially non-null protein	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		drh-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
DTH2	Flowering time	2 Mutations: Coding SNP	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Wu W; Zheng XM; Lu G ; et al. (2013) Association of functional nucleotide polymorphisms at DTH2 with the northward expansion of rice cult[...]	GP00000239	DTH2 O82118	Physiology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		DTH2	Oryza sativa rice - (species)	Published - Accepted by Curator
Dvl2	Organ size (tail)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Mansour TA; Lucot K; Konopelski SE ; et al. (2018) Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 [...]	GP00002110	DVL2 O14641	Morphology	single base deletion found on CFA 5(g.32195043_32195044del) that is homozygous in the three screw tail breeds - predicted to lead to a frameshift mutation and cause a premature stop codon that truncates the translated protein by 23 amino acids (p.Pro684LeufsX26) - 26 altered amino acids are predicted to be present in the highly conserved C-terminus of the mutant protein. N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		Dvl2	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
dwarf-8 (d8)	Plant size (dwarfism)	Coding, Deletion N	Zea mays (species) D	Domesticated	Linkage Mapping	Peng J; Richards DE; Hartley NM ; et al. (1999) 'Green revolution' genes encode mutant gibberellin response modulators. 2 Additional References Camus-Kulandaivelu L; Veyrieras JB; Madur D (2006) Maize adaptation to temperate climate: relationship between population structure and polymorphism in[...] Thornsberry JM; Goodman MM; Doebley J (2001) Dwarf8 polymorphisms associate with variation in flowering time.	GP00000241	D8 Q9ST48	Morphology	330bp deletion to V84 N	Zea mays (species)	Zea mays (species) D		dwarf-8 (d8)	Zea mays (species)	Published - Accepted by Curator
EARLY FLOWERING 3 (here = Mat-a)	Flowering time	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Linkage Mapping	Zakhrabekova S; Gough SP; Braumann I ; et al. (2012) Induced mutations in circadian clock regulator Mat-a facilitated short-season adaptation and range e[...]	GP00000243	ELF3 O82804	Physiology	4bp deletion resulting in truncated protein ; this deletion seem to have evolved multiple times (fragile site?) N	Hordeum vulgare (species)	Hordeum vulgare (species) D		EARLY FLOWERING 3 (here = Mat-a)	Hordeum vulgare (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)	Flowering time	Coding, Indel	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jiménez-Gómez JM; Wallace AD; Maloof JN (2010) Network analysis identifies ELF3 as a QTL for the shade avoidance response in Arabidopsis. 3 Additional References Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...] Coluccio MP; Sanchez SE; Kasulin L (2011) Genetic mapping of natural variation in a shade avoidance response: ELF3 is the candidate gene for a[...] Undurraga SF; Press MO; Legendre M (2012) Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3.	GP00000244	ELF3 O82804	Physiology	Background-dependent effects of extensive polyQ coding variation	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		EARLY FLOWERING 3(ELF3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)	Flowering time (latitudinal adaptation)	Coding, Deletion N	Glycine max soybean - (species) D	Domesticated	Linkage Mapping	Lu S; Zhao X; Hu Y ; et al. (2017) Natural variation at the soybean J locus improves adaptation to the tropics and enhances yield.	GP00001683	CYP75B1 Q9SD85	Physiology	recessive allele responsible for the LJ trait - 10-bp deletion predicted to cause a frameshift resulting in premature termination of translation after 195 amino acids in the 714-amino-acid protein N	Glycine max soybean - (species)	Glycine max soybean - (species) D		EARLY FLOWERING 3(ELF3)	Glycine max soybean - (species)	Published - Accepted by Curator
EARLY FLOWERING 3(ELF3) [possible pseudo-replicate]	Plant growth (hypocotyl elongation ; temperature-dependent)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Raschke A; Ibañez C; Ullrich KK ; et al. (2015) Natural variants of ELF3 affect thermomorphogenesis by transcriptionally modulating PIF4-dependent a[...]	GP00001245	ELF3 O82804	Morphology	A362V	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		EARLY FLOWERING 3(ELF3) [possible pseudo-replicate]	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
EARLY FLOWERING 3/ EARLY MATURITY 8	Flowering time	Coding, SNP N	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Faure S; Turner AS; Gruszka D ; et al. (2012) Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]	GP00000245	ELF3 O82804	Physiology	Premature stop codon; C-to-T point mutation in exon 2 N	Hordeum vulgare (species)	Hordeum vulgare (species)		EARLY FLOWERING 3/ EARLY MATURITY 8	Hordeum vulgare (species)	Published - Accepted by Curator
EARLY FLOWERING 3/ EARLYMATURITY8	Flowering time	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Linkage Mapping	Faure S; Turner AS; Gruszka D ; et al. (2012) Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]	GP00000246	ELF3 O82804	Physiology	4bp deletion resulting in truncated protein ; this deletion seem to have evolved multiple times (fragile site?) N	Hordeum vulgare (species)	Hordeum vulgare (species) D		EARLY FLOWERING 3/ EARLYMATURITY8	Hordeum vulgare (species)	Published - Accepted by Curator
Early flowering1 (EL1)	Flowering time (heading date)	Coding, SNP	Oryza sativa Japonica Group Japanese rice - (no rank) D	Domesticated	Linkage Mapping	Kwon CT; Yoo SC; Koo BH ; et al. (2014) Natural variation in Early flowering1 contributes to early flowering in japonica rice under long day[...]	GP00001636	HD16 Q852L0	Physiology	G476C p.Gly159Ala in the serine/threonine kinase domain leading to non-functional protein	Oryza sativa rice - (species)	Oryza sativa Japonica Group Japanese rice - (no rank) D		Early flowering1 (EL1)	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
Early flowering1 (EL1)	Flowering time (heading date)	Coding, SNP	Oryza sativa Japonica Group Japanese rice - (no rank) D	Domesticated	Linkage Mapping	Kwon CT; Yoo SC; Koo BH ; et al. (2014) Natural variation in Early flowering1 contributes to early flowering in japonica rice under long day[...]	GP00001637	HD16 Q852L0	Physiology	G991A p.Ala331Thr in the serine/threonine kinase domain leading to non-functional protein	Oryza sativa rice - (species)	Oryza sativa Japonica Group Japanese rice - (no rank) D		Early flowering1 (EL1)	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
Ectodysplasin (EDA)	Scales (loss) Femoral glands (absent) Tooth number	Coding, Insertion	Pogona vitticeps central bearded dragon - (species) D	Intraspecific	Candidate Gene	Di-Poï N; Milinkovitch MC (2016) The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendage[...]	GP00002040	Eda O54693	Morphology Morphology Morphology	5′688–bp insertion of a transposon of the LTR-Gypsy family which generates a new splice donor site (gt) 42 bases upstream of the wild-type donor site; thus generating a 14–amino acid deletion in the corresponding transcript	Pogona vitticeps central bearded dragon - (species)	Pogona vitticeps central bearded dragon - (species) D		Ectodysplasin (EDA)	Pogona vitticeps central bearded dragon - (species)	Published - Accepted by Curator
EDAR	Hair thickness Eccrine gland density Ear traits = lobe size / lobe attachment / helix rolling / ear protrusion Tooth morphology (shovel-shaped incisors)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Fujimoto A; Kimura R; Ohashi J ; et al. (2008) A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickne[...] 4 Additional References Kamberov YG; Wang S; Tan J (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant. Adhikari K; Reales G; Smith AJ (2015) A genome-wide association study identifies multiple loci for variation in human ear morphology. Park JH; Yamaguchi T; Watanabe C (2012) Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits. Kimura R; Yamaguchi T; Takeda M (2009) A common variation in EDAR is a genetic determinant of shovel-shaped incisors.	GP00000256	EDAR Q9UNE0	Morphology Morphology Morphology Morphology	p.Val370Ala; functionally validated in mouse	Homo sapiens human - (species)	Homo sapiens human - (species) D		EDAR	Homo sapiens human - (species)	Published - Accepted by Curator
EDAR	Scales (reduced)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002359	EDAR Q9UNE0	Morphology	Several deletions in the EDAR1 coding region. N	Danio rerio zebrafish - (species)	Sinocyclocheilus anshuiensis (species) D Sinocyclocheilus grahami (species) D Sinocyclocheilus rhinocerous (species) D		EDAR	Sinocyclocheilus anshuiensis (species) Sinocyclocheilus grahami (species) Sinocyclocheilus rhinocerous (species)	Published - Accepted by Curator
EDAR	Scales (reduced)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002360	EDAR Q9UNE0	Morphology; Physiology	Deletion of a large part of the EDAR2 coding region. N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		EDAR	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Simonson TS; Yang Y; Huff CD ; et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. 3 Additional References Bigham A; Bauchet M; Pinto D (2010) Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...] Xu S; Li S; Yang Y (2011) A genome-wide search for signals of high-altitude adaptation in Tibetans. Xiang K; Ouzhuluobu ; Peng Y (2013) Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high[...]	GP00000261	EGLN1 Q9GZT9	Physiology	possibly D4E	Homo sapiens human - (species)	Homo sapiens human - (species) D		EGLN1	Homo sapiens human - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Panthera uncia snow leopard - (species) D	Interspecific	Association Mapping	Cho YS; Hu L; Hou H ; et al. (2013) The tiger genome and comparative analysis with lion and snow leopard genomes.	GP00001358	EGLN1 Q9GZT9	Physiology	p.Met39Lys	Panthera (genus)	Panthera uncia snow leopard - (species) D		EGLN1	Panthera uncia snow leopard - (species)	Published - Accepted by Curator
EGLN1	Hypoxia response	Coding, SNP	Heterocephalus glaber naked mole-rat - (species) D	Interspecific	Association Mapping	Kim EB; Fang X; Fushan AA ; et al. (2011) Genome sequencing reveals insights into physiology and longevity of the naked mole rat.	GP00001759	EGLN1 Q9GZT9	Physiology	unique amino-acid changes in different positions of EGLN1 (Pro15, Arg17 and Arg36)	Rodentia rodent - (order)	Heterocephalus glaber naked mole-rat - (species) D		EGLN1	Heterocephalus glaber naked mole-rat - (species)	Published - Accepted by Curator
Ehd1 (Response regulator)	Flowering time	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Doi K; Izawa T; Fuse T ; et al. (2004) Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-[...]	GP00000263	EHD1 Q9H4M9	Physiology	G218R in highly conserved region in GARP domain	Oryza glaberrima African rice - (species)	Oryza sativa rice - (species)		Ehd1 (Response regulator)	Oryza sativa rice - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth absence (no enamel production)	Coding, Deletion N	Eubalaena glacialis North Atlantic right whale - (species) D Megaptera novaeangliae humpback whale - (species) D Eschrichtius robustus grey whale - (species) D Caperea marginata pygmy right whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001939	ENAM Q9NRM1	Physiology	1-bp deletion. Various frameshift mutations were found in the distinct species. N	Cetacea whales - (order)	Eubalaena glacialis North Atlantic right whale - (species) D Megaptera novaeangliae humpback whale - (species) D Eschrichtius robustus grey whale - (species) D Caperea marginata pygmy right whale - (species) D		enamelin (ENAM)	Eubalaena glacialis North Atlantic right whale - (species) Megaptera novaeangliae humpback whale - (species) Eschrichtius robustus grey whale - (species) Caperea marginata pygmy right whale - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	2 Mutations: Coding Deletion N	Kogia sima dwarf sperm whale - (species) D Kogia breviceps pygmy sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001942	ENAM Q9NRM1	Physiology	2 mutations	Physeter catodon sperm whale - (species)	Kogia sima dwarf sperm whale - (species) D Kogia breviceps pygmy sperm whale - (species) D		enamelin (ENAM)	Kogia sima dwarf sperm whale - (species) Kogia breviceps pygmy sperm whale - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	3 Mutations: Coding N	Orycteropus afer aardvark - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]	GP00001943	ENAM Q9NRM1	Physiology	3 mutations	Elephantulus rufescens East African long-eared elephant shrew - (species)	Orycteropus afer aardvark - (species) D		enamelin (ENAM)	Orycteropus afer aardvark - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	Coding, Unknown N	Manis pentadactyla Chinese pangolin - (species) D Manis tricuspis Tree pangolin - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]	GP00001944	ENAM Q9NRM1	Physiology	multiple deletions and insertions less than 9bp causing frameshift N	Canis lupus familiaris dog - (subspecies)	Manis pentadactyla Chinese pangolin - (species) D Manis tricuspis Tree pangolin - (species) D		enamelin (ENAM)	Manis pentadactyla Chinese pangolin - (species) Manis tricuspis Tree pangolin - (species)	Published - Accepted by Curator
enamelin (ENAM)	Tooth composition (no enamel production)	Coding, Unknown N	Bradypus tridactylus Pale-throated sloth - (species) D Tamandua tetradactyla southern tamandua - (species) D Dasypus novemcinctus nine-banded armadillo - (species) D Euphractus sexcinctus (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Murphy WJ ; et al. (2009) Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]	GP00001945	ENAM Q9NRM1	Physiology	multiple frameshift insertions and deletions N	Canis lupus familiaris dog - (subspecies)	Bradypus tridactylus Pale-throated sloth - (species) D Tamandua tetradactyla southern tamandua - (species) D Dasypus novemcinctus nine-banded armadillo - (species) D Euphractus sexcinctus (species) D		enamelin (ENAM)	Bradypus tridactylus Pale-throated sloth - (species) Tamandua tetradactyla southern tamandua - (species) Dasypus novemcinctus nine-banded armadillo - (species) Euphractus sexcinctus (species)	Published - Accepted by Curator
enamelysin (MMP20)	Tooth absence (no enamel production)	Coding, Insertion N	Balaenoptera physalus Fin whale - (species) D Balaena mysticetus bowhead whale - (species) D Megaptera novaeangliae humpback whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001940	MMP20 O60882	Physiology	insertion of a CHR-2 SINE retroposon in exon 2 of MMP20 which would result in premature truncation of the MMP20 protein owing to stop codons in all possible reading frames of the CHR-2 SINE. The length of the MMP20 SINE ranges from 302 bp (B. musculus) to 318 bp (B. physalus). This mutation is found in eight investigated species of baleen whales. Other inactivating mutations (nonsense and frameshift mutations) are found in various species N	Physeter catodon sperm whale - (species)	Balaenoptera physalus Fin whale - (species) D Balaena mysticetus bowhead whale - (species) D Megaptera novaeangliae humpback whale - (species) D		enamelysin (MMP20)	Balaenoptera physalus Fin whale - (species) Balaena mysticetus bowhead whale - (species) Megaptera novaeangliae humpback whale - (species)	Published - Accepted by Curator
enamelysin (MMP20)	Tooth composition (no enamel production)	Coding, SNP N	Kogia breviceps pygmy sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001941	MMP20 O60882	Physiology	opal stop codon (TGA) in the propeptide-coding region of MMP20 exon 2 in a single individual of the pygmy sperm whale Kogia breviceps N	Kogia sima dwarf sperm whale - (species)	Kogia breviceps pygmy sperm whale - (species) D		enamelysin (MMP20)	Kogia breviceps pygmy sperm whale - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000267	END3 P39013	Physiology Physiology	S258N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
END3	Temperature tolerance Virulence	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 1 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus.	GP00000268	END3 P39013	Physiology Physiology	D268N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		END3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Endothelin receptor B	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Metallinos DL; Bowling AT; Rine J (1998) A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome:[...] 2 Additional References Santschi EM; Purdy AK; Valberg SJ (1998) Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses. Yang GC; Croaker D; Zhang AL (1998) A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndr[...]	GP00000269	Ednrb P48302	Morphology	Ile118Lys	Equus caballus horse - (species)	Equus caballus horse - (species) D		Endothelin receptor B	Equus caballus horse - (species)	Published - Accepted by Curator
Endothelin receptor B	Coloration (feathers ; white-spotting)	Coding, SNP	Coturnix japonica Japanese quail - (species) D	Domesticated	Linkage Mapping	Miwa M; Inoue-Murayama M; Aoki H ; et al. (2007) Endothelin receptor B2 (EDNRB2) is associated with the panda plumage colour mutation in Japanese qua[...]	GP00000270	Ednrb P48302	Morphology	c.995G>A p.R332H	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species) D		Endothelin receptor B	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
Endothelin receptor B2	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Kinoshita K; Akiyama T; Mizutani M ; et al. (2014) Endothelin receptor B2 (EDNRB2) is responsible for the tyrosinase-independent recessive white (mo(w)[...]	GP00001360	EDNRB2 W8VUK4	Morphology	c.1008G>T p.Cys244Phe	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Endothelin receptor B2	Gallus gallus chicken - (species)	Published - Accepted by Curator
Endothelin receptor B2	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Kinoshita K; Akiyama T; Mizutani M ; et al. (2014) Endothelin receptor B2 (EDNRB2) is responsible for the tyrosinase-independent recessive white (mo(w)[...]	GP00001361	EDNRB2 W8VUK4	Morphology	c.G1272A p.Arg332His	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Endothelin receptor B2	Gallus gallus chicken - (species)	Published - Accepted by Curator
Endothelin receptor B2	Coloration (feathers ; white-spotting)	Coding, SNP	Anas platyrhynchos mallard - (species) D	Domesticated	Candidate Gene	Li L; Li D; Liu L ; et al. (2015) Endothelin Receptor B2 (EDNRB2) Gene Is Associated with Spot Plumage Pattern in Domestic Ducks (Anas[...]	GP00002378	EDNRB2 W8VUK4	Morphology		Anas platyrhynchos mallard - (species)	Anas platyrhynchos mallard - (species) D		Endothelin receptor B2	Anas platyrhynchos mallard - (species)	Published - Accepted by Curator
Enhanced shoot growth under mannitol stress 2 (EGM2)	Plant growth (shoot growth under stress)	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Trontin C; Kiani S; Corwin JA ; et al. (2014) A pair of receptor-like kinases is responsible for natural variation in shoot growth response to man[...]	GP00001630	At1g11300 Q9SXB4	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Enhanced shoot growth under mannitol stress 2 (EGM2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)	Increase in antiviral ribonuclease activity	Coding, SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Zhang J; Rosenberg HF (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.	GP00000272	RNASE2 P10153	Physiology	Arg64Ser	Primates (order)	Catarrhini (parvorder)		eosinophil-derived neurotoxin (EDN)	Catarrhini (parvorder)	Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)	Increase in antiviral ribonuclease activity	Coding, SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Zhang J; Rosenberg HF (2002) Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.	GP00000273	RNASE2 P10153	Physiology	Thr132Arg	Primates (order)	Catarrhini (parvorder)		eosinophil-derived neurotoxin (EDN)	Catarrhini (parvorder)	Published - Accepted by Curator
EPAS1	Hypoxia response	Coding, SNP	Panthera uncia snow leopard - (species) D	Interspecific	Association Mapping	Cho YS; Hu L; Hou H ; et al. (2013) The tiger genome and comparative analysis with lion and snow leopard genomes.	GP00001357	EPAS1 Q99814	Physiology	two species-specific amino acid changes: Val663Ile and Cys794Arg - whether both or only one is affecting the phenotype is unknown	Panthera (genus)	Panthera uncia snow leopard - (species) D		EPAS1	Panthera uncia snow leopard - (species)	Published - Accepted by Curator
EPAS1	Hypoxia response	Coding, SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Association Mapping	Schweizer RM; Velotta JP; Ivy CM ; et al. (2019) Physiological and genomic evidence that selection on the transcription factor Epas1 has altered card[...]	GP00002062	EPAS1 Q99814	Physiology	non-synonymous polymorphism located at site 755 in the 14th exon that changes threonine to methionine Thr755Met	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		EPAS1	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
EphB2	Feathers (crest morphology)	Coding, SNP	Columba livia rock pigeon - (species) D	Domesticated	Association Mapping	Shapiro MD; Kronenberg Z; Li C ; et al. (2013) Genomic diversity and evolution of the head crest in the rock pigeon. 1 Additional References Vickrey AI; Domyan ET; Horvath MP (2015) Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Misse[...]	GP00000275	EPHB2 P28693	Morphology	Arg758Cys (C>T) p.R758C	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		EphB2	Columba livia rock pigeon - (species)	Published - Accepted by Curator
EphB2	Feathers (crest morphology)	Coding, SNP	Streptopelia risoria ringneck dove - (species) D	Domesticated	Candidate Gene	Vickrey AI; Domyan ET; Horvath MP ; et al. (2015) Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Misse[...]	GP00000276	EPHB2 P28693	Morphology	Gly636Arg (G>A)	Streptopelia risoria ringneck dove - (species)	Streptopelia risoria ringneck dove - (species) D		EphB2	Streptopelia risoria ringneck dove - (species)	Published - Accepted by Curator
Epithiospecifier protein (ESP)	Plant secondary metabolite (glucosinolate) Herbivore resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001) The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]	GP00000279	ESP Q8RY71	Physiology Physiology	deletion of 124 bases that eliminates a splice site and 100 nucleotides of the ORF N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Epithiospecifier protein (ESP)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Eleusine indica goosegrass - (species) D	Intraspecific	Candidate Gene	Baerson SR; Rodriguez DJ; Tran M ; et al. (2002) Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshik[...]	GP00001888	At2g45300 P05466	Physiology	Pro106Ser leading to 2-4-fold resistance	Eleusine indica goosegrass - (species)	Eleusine indica goosegrass - (species) D		EPSPS	Eleusine indica goosegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Echinochloa colona (species) D	Intraspecific	Candidate Gene	Morran S; Moretti ML; Brunharo CA ; et al. (2018) Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]	GP00001889	At2g45300 P05466	Physiology	Pro106Ser leading to resistance	Echinochloa colona (species)	Echinochloa colona (species) D		EPSPS	Echinochloa colona (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Echinochloa colona (species) D	Intraspecific	Candidate Gene	Morran S; Moretti ML; Brunharo CA ; et al. (2018) Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]	GP00001890	At2g45300 P05466	Physiology	Pro106Leu leading to resistance	Echinochloa colona (species)	Echinochloa colona (species) D		EPSPS	Echinochloa colona (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Echinochloa colona (species) D	Intraspecific	Candidate Gene	Morran S; Moretti ML; Brunharo CA ; et al. (2018) Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]	GP00001891	At2g45300 P05466	Physiology	Pro106Thr leading to resistance	Echinochloa colona (species)	Echinochloa colona (species) D		EPSPS	Echinochloa colona (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Candidate Gene	Bell Michael S; Hager Aaron G; Tranel Patrick J (2013 ) Multiple resistance to herbicides from four site-of-action groups in waterhemp (Amaranthus tubercula[...]	GP00001892	At2g45300 P05466	Physiology	resistance not due to EPSPS amplification; partly due to P106S mutation	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		EPSPS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium multiflorum Italian ryegrass - (species) D	Intraspecific	Candidate Gene	Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008 ) Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]	GP00001896	At2g45300 P05466	Physiology	Pro106Ser	Lolium multiflorum Italian ryegrass - (species)	Lolium multiflorum Italian ryegrass - (species) D		EPSPS	Lolium multiflorum Italian ryegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium multiflorum Italian ryegrass - (species) D	Intraspecific	Candidate Gene	Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008 ) Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]	GP00001897	At2g45300 P05466	Physiology	Pro106Ala conferring 5-15-fold resistance	Lolium multiflorum Italian ryegrass - (species)	Lolium multiflorum Italian ryegrass - (species) D		EPSPS	Lolium multiflorum Italian ryegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Eleusine indica goosegrass - (species) D	Intraspecific	Candidate Gene	Ng CH; Wickneswari R; Salmijah S ; et al. (2003 ) Gene polymorphisms in glyphosate‐resistant and‐susceptible biotypes of Eleusine indica from Malaysia[...]	GP00001898	At2g45300 P05466	Physiology	Pro106Thr leading to 3-fold resistance	Eleusine indica goosegrass - (species)	Eleusine indica goosegrass - (species) D		EPSPS	Eleusine indica goosegrass - (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Digitaria insularis (species) D	Intraspecific	Candidate Gene	de Carvalho LB; Alves PL; González-Torralva F ; et al. (2012) Pool of resistance mechanisms to glyphosate in Digitaria insularis.	GP00001899	At2g45300 P05466	Physiology	Pro106Thr	Digitaria insularis (species)	Digitaria insularis (species) D		EPSPS	Digitaria insularis (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Kaundun SS; Dale RP; Zelaya IA ; et al. (2011) A novel P106L mutation in EPSPS and an unknown mechanism(s) act additively to confer resistance to g[...]	GP00001900	At2g45300 P05466	Physiology	Pro106Leu conferring a 1.7-fold resistance increase to glyphosate at the whole plant level	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012 ) Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]	GP00001901	At2g45300 P05466	Physiology	Pro106Ser	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012 ) Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]	GP00001902	At2g45300 P05466	Physiology	Pro106Thr	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
EPSPS	Xenobiotic resistance (herbicides; glyphosate)	Coding, SNP	Lolium rigidum (species) D	Intraspecific	Candidate Gene	Yu Q; Cairns A; Powles S (2007) Glyphosate, paraquat and ACCase multiple herbicide resistance evolved in a Lolium rigidum biotype.	GP00001903	At2g45300 P05466	Physiology	Pro106Ala	Lolium rigidum (species)	Lolium rigidum (species) D		EPSPS	Lolium rigidum (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000281	ERG11 P10613	Physiology	Y132H	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000282	ERG11 P10613	Physiology	S405F	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000283	ERG11 P10613	Physiology	G464S	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, SNP	Candida albicans (species) D	Intraspecific	Candidate Gene	Sanglard D; Ischer F; Koymans L ; et al. (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]	GP00000284	ERG11 P10613	Physiology	R467K	Candida albicans (species)	Candida albicans (species) D		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG11 = CYP51A1	Xenobiotic resistance	Coding, Indel	Candida albicans (species)	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00000285	ERG11 P10613	Physiology	Copy number Variant	Candida albicans (species)	Candida albicans (species)		ERG11 = CYP51A1	Candida albicans (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000286	ERG3 P32353	Physiology	Arg63Stop A187T in line 21 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001744	ERG3 P32353	Physiology	Ser76Stop C227A in line 22 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001745	ERG3 P32353	Physiology	Ser95Stop C284A in line 23 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001746	ERG3 P32353	Physiology	Trp205Stop G615A in line 24 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001747	ERG3 P32353	Physiology	Trp205Stop G615A in line 25 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001748	ERG3 P32353	Physiology	Trp205Stop G615A in line 26 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001749	ERG3 P32353	Physiology	Trp205Stop G615A in line 27 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001750	ERG3 P32353	Physiology	29-bp duplication in line 28 at nucleotide position 641 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001751	ERG3 P32353	Physiology	Trp219Stop G656A in line 29 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001752	ERG3 P32353	Physiology	Gly235Ser G703A in line 30 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001753	ERG3 P32353	Physiology	Tyr299Stop C897A in line 31 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001754	ERG3 P32353	Physiology	Gly300Arg G898C in line 32 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001755	ERG3 P32353	Physiology	Asp307Ala A920C in line 33 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001756	ERG3 P32353	Physiology	1-bp deletion in line 34 A980- N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG3	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00001757	ERG3 P32353	Physiology	60-bp deletion at position 253 in line 35 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG5	Xenobiotic resistance (drug)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000287	ERG5 P54781	Physiology	60bp deletion N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG6	Xenobiotic resistance (drug)	Coding, Unknown	Saccharomyces cerevisiae baker's yeast - (species)	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000288	erg6 O14321	Physiology	7 unique mutations in ERG6 within a total 19 lines ; 4 of these mutations evolved multiple times	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		ERG6	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ERG7	Xenobiotic resistance (drug)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Lo DS; Otto SP (2012) Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]	GP00000289	ERG7 P38604	Physiology	Phe699Leu	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		ERG7	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Newcomb RD; Campbell PM; Ollis DL ; et al. (1997) A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]	GP00000294	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)		esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia cuprina Australian sheep blowfly - (species)	Intraspecific	Candidate Gene	Jackson CJ; Liu JW; Carr PD ; et al. (2013) Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]	GP00000295	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia cuprina Australian sheep blowfly - (species)	Lucilia cuprina Australian sheep blowfly - (species)		esterase isozyme E3	Lucilia cuprina Australian sheep blowfly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species)	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000296	LcaE7 Q25252	Physiology	Trp251Leu	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species)		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000297	LcaE7 Q25252	Physiology	Trp251Ser	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Lucilia sericata common green bottle fly - (species) D	Intraspecific	Candidate Gene	Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006) Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]	GP00000298	LcaE7 Q25252	Physiology	Gly137Asp	Lucilia sericata common green bottle fly - (species)	Lucilia sericata common green bottle fly - (species) D		esterase isozyme E3	Lucilia sericata common green bottle fly - (species)	Published - Accepted by Curator
esterase isozyme E3	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. de Carvalho RA; Torres TT; de Azeredo-Espin AM (2006) A survey of mutations in the Cochliomyia hominivorax (Diptera: Calliphoridae) esterase E3 gene assoc[...]	GP00002584	alphaE7 A0A0G3Z837	Physiology	G137D	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D		esterase isozyme E3	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
esterase isozyme E7 = E3	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Claudianos C; Russell RJ; Oakeshott JG (1999) The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]	GP00000299	LcaE7 Q25252	Physiology	Gly137Asp	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		esterase isozyme E7 = E3	Musca domestica house fly - (species)	Published - Accepted by Curator
ETC2	Trichome density (leaf)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Hilscher J; Schlötterer C; Hauser MT (2009) A single amino acid replacement in ETC2 shapes trichome patterning in natural Arabidopsis population[...]	GP00001237	ETC2 Q84RD1	Morphology	K19E	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		ETC2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FAAH	Anxiety (fear reduction)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Dincheva I; Drysdale AT; Hartley CA ; et al. (2015) FAAH genetic variation enhances fronto-amygdala function in mouse and human.	GP00000301	Faah P97612	Behavior	Pro129Thr (C385A; common variant rs324420)	Homo sapiens human - (species)	Homo sapiens human - (species)		FAAH	Homo sapiens human - (species)	Published - Accepted by Curator
FAD2 (BnaA.FAD2.a)	Oil composition Oil yield	Coding, Insertion N	Brassica napus rape - (species) D	Domesticated	Linkage Mapping	Yang Q; Fan C; Guo Z ; et al. (2012) Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific ma[...]	GP00000302	FAD2 P46313	Physiology Physiology	4bp insertion resulting in frameshift and premature stop codon N	Brassica napus rape - (species)	Brassica napus rape - (species) D		FAD2 (BnaA.FAD2.a)	Brassica napus rape - (species)	Published - Accepted by Curator
FAD2A	Oil composition (oleate levels)	Coding, SNP N	Arachis hypogaea peanut - (species) D	Domesticated	Candidate Gene	Jung S; Powell G; Moore K ; et al. (2000) The high oleate trait in the cultivated peanut [Arachis hypogaea L]. II. Molecular basis and genetic[...]	GP00002075	FAD2A E2GJC1	Physiology	D150N in a residue that is absolutely conserved among other desaturases N	Arachis hypogaea peanut - (species)	Arachis hypogaea peanut - (species) D		FAD2A	Arachis hypogaea peanut - (species)	Published - Accepted by Curator
FAD2B	Oil composition (oleate levels)	Coding, Insertion N	Arachis hypogaea peanut - (species) D	Domesticated	Candidate Gene	Patel M; Jung S; Moore K ; et al. (2004) High-oleate peanut mutants result from a MITE insertion into the FAD2 gene.	GP00002073	FAD2B Q9LKK6	Physiology	insertion of 205-bp miniature inverted-repeat transposable element (MITE) called ahMITE1 at position 665 near the center of the coding region in the case of MF; which causes a frameshift N	Arachis hypogaea peanut - (species)	Arachis hypogaea peanut - (species) D		FAD2B	Arachis hypogaea peanut - (species)	Published - Accepted by Curator
FAD2B	Oil composition (oleate levels)	Coding, Insertion N	Arachis hypogaea peanut - (species) D	Domesticated	Candidate Gene	Patel M; Jung S; Moore K ; et al. (2004) High-oleate peanut mutants result from a MITE insertion into the FAD2 gene.	GP00002074	FAD2B Q9LKK6	Physiology	insertion of 205-bp miniature inverted-repeat transposable element (MITE) called ahMITE1 at position 997 of the coding region; which causes a frameshift N	Arachis hypogaea peanut - (species)	Arachis hypogaea peanut - (species) D		FAD2B	Arachis hypogaea peanut - (species)	Published - Accepted by Curator
FAR (pheromone gland FAR)	Pheromone production (isomeric/chirality divergence)	Coding, Unknown	Ostrinia nubilalis European corn borer - (species)	Intraspecific	Linkage Mapping	Lassance JM; Groot AT; Liénard MA ; et al. (2010) Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones. 2 Additional References Lassance JM; Liénard MA; Antony B (2013) Functional consequences of sequence variation in the pheromone biosynthetic gene pgFAR for Ostrinia [...] Unbehend M; Kozak GM; Koutroumpa F (2021) bric à brac controls sex pheromone choice by male European corn borer moths.	GP00000304	pgFAR D3U9W3	Physiology	Candidate a.a. substitutions with effect validated in vitro	Ostrinia nubilalis European corn borer - (species)	Ostrinia nubilalis European corn borer - (species)		FAR (pheromone gland FAR)	Ostrinia nubilalis European corn borer - (species)	Published - Accepted by Curator
ferredoxin	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001530	PF3D7_1318100 Q8IED5	Physiology	p.Asp193Tyr	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		ferredoxin	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
FGF20	Organ loss (feathers ; scales)	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Wells KL; Hadad Y; Ben-Avraham D ; et al. (2012) Genome-wide SNP scan of pooled DNA reveals nonsense mutation in FGF20 in the scaleless line of feath[...]	GP00002171	FGF20 Q9NP95	Morphology	g.62878803A>T c.535A>T p.R179* N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		FGF20	Gallus gallus chicken - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Cadieu E; Neff MW; Quignon P ; et al. (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00000310	Fgf5 P15656	Morphology	Cys95Phe	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FGF5	Hair length (length)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Drögemüller C; Rüfenacht S; Wichert B ; et al. (2007) Mutations within the FGF5 gene are associated with hair length in cats. 1 Additional References Kehler JS; David VA; Schäffer AA (2007 Sep-Oct) Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired p[...]	GP00000311	Fgf5 P15656	Morphology	c.474delT resulting in frameshift N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		FGF5	Felis catus domestic cat - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Legrand R; Tiret L; Abitbol M (2014) Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys.	GP00001369	Fgf5 P15656	Morphology	c.433_434delAT frameshift deletion leading to a stop codon at position 159 N	Equus asinus ass - (species)	Equus asinus ass - (species) D		FGF5	Equus asinus ass - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP N	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Legrand R; Tiret L; Abitbol M (2014) Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys.	GP00001370	Fgf5 P15656	Morphology	c.245G>A p.W82* nonsense mutation leading to stop codon at position 82 N	Equus asinus ass - (species)	Equus asinus ass - (species) D		FGF5	Equus asinus ass - (species)	Published - Accepted by Curator
FGF5	Hair length (length)	Coding, Insertion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Drögemüller C; Rüfenacht S; Wichert B ; et al. (2007) Mutations within the FGF5 gene are associated with hair length in cats. 1 Additional References Kehler JS; David VA; Schäffer AA (2007 Sep-Oct) Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired p[...]	GP00002172	Fgf5 P15656	Morphology	c.ins356T resulting in frameshift N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		FGF5	Felis catus domestic cat - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mesocricetus auratus golden hamster - (species) D	Domesticated	Candidate Gene	Yoshizawa Y; Wada K; Shimoi G ; et al. (2015) A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster.	GP00002173	Fgf5 P15656	Morphology	c.546delG p.Arg184GlyfsX6 N	Mesocricetus auratus golden hamster - (species)	Mesocricetus auratus golden hamster - (species) D		FGF5	Mesocricetus auratus golden hamster - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dierks C; Mömke S; Philipp U ; et al. (2013) Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. 1 Additional References Cadieu E; Neff MW; Quignon P (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00002174	Fgf5 P15656	Morphology	g.4528639C>T c.578C>T p.A193V	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dierks C; Mömke S; Philipp U ; et al. (2013) Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. 1 Additional References Cadieu E; Neff MW; Quignon P (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00002175	Fgf5 P15656	Morphology	g.8193T>A splice site	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FGF5	Hair length	Coding, Insertion	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dierks C; Mömke S; Philipp U ; et al. (2013) Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. 1 Additional References Cadieu E; Neff MW; Quignon P (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00002176	Fgf5 P15656	Morphology	c.559_560dupGG p.R188Afs*73	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dierks C; Mömke S; Philipp U ; et al. (2013) Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. 1 Additional References Cadieu E; Neff MW; Quignon P (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00002177	Fgf5 P15656	Morphology	c.556_571del16 p.A186Tfs*69	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP N	Cavia porcellus domestic guinea pig - (species) D	Domesticated	Candidate Gene	Yu F; Liu Z; Jiao S ; et al. (2018) A nonsense mutation in the FGF5 gene is associated with the long-haired phenotype in domestic guinea[...]	GP00002178	Fgf5 P15656	Morphology	c.403C>T p.Arg135* N	Cavia porcellus domestic guinea pig - (species)	Cavia porcellus domestic guinea pig - (species) D		FGF5	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Indel N	Lama glama llama - (species) D	Domesticated	Candidate Gene	Daverio MS; Vidal-Rioja L; Frank EN ; et al. (2017) Molecular characterization of the llama FGF5 gene and identification of putative loss of function mu[...]	GP00002179	Fgf5 P15656	Morphology	a single base deletion (c.348delA) + a 12-bp insertion (c.351_352insCATATAACATAG) N	Lama guanicoe guanaco - (species)	Lama glama llama - (species) D		FGF5	Lama glama llama - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP N	Lama glama llama - (species) D Vicugna pacos alpaca - (species) D	Domesticated	Candidate Gene	Daverio MS; Vidal-Rioja L; Frank EN ; et al. (2017) Molecular characterization of the llama FGF5 gene and identification of putative loss of function mu[...] 2 Additional References Pallotti S; Pediconi D; Subramanian D (2018) Evidence of post-transcriptional readthrough regulation in FGF5 gene of alpaca. Fan R; Gu Z; Guang X (2020) Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca.	GP00002180	Fgf5 P15656	Morphology	transition C>T at position 499 downstream of the ATG codon with transcriptional readthrough ; difference in post-transcriptional readthrough may underlie the different fleece types of the alpaca suri and huacaya breeds ; derived allele was introgressed from lamas to alpacas N	Lama guanicoe guanaco - (species)	Lama glama llama - (species) D Vicugna pacos alpaca - (species) D		FGF5	Lama glama llama - (species) Vicugna pacos alpaca - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Hébert JM; Rosenquist T; Götz J ; et al. (1994) FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. 1 Additional References Sundberg JP; Rourk MH; Boggess D (1997) Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin graf[...]	GP00002441	Fgf5 P15656	Morphology	Deletion which extends at least 2kb upstream of the Fgf5 translational start site and terminates at the end of the first exon or beginning of the first intron. N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D		FGF5	Mus musculus house mouse - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Mizuno S; Iijima S; Okano T ; et al. (2011) Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.	GP00002442	Fgf5 P15656	Morphology	Deletion of a 9.3-kb region in the Fgf5 gene including exon 3 and its 5' and 3' flanking sequences. The genomic deletion site also shows insertion of a 498-bp early transposon element long terminal repeat. N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D		FGF5	Mus musculus house mouse - (species)	Published - Accepted by Curator
FGF5	Hair length	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Housley DJ; Venta PJ (2006) The long and the short of it: evidence that FGF5 is a major determinant of canine 'hair'-itability.	GP00002443	Fgf5 P15656	Morphology	Presence of a duplication in a relatively non-conserved region of the gene and a missense mutation resulting in the substitution of Phe for Cys in a highly conserved region. Genotyping of 218 dogs from three breeds fixed for long hair; eight breeds fixed for short hair and five breeds in which long hair is segregating provided evidence that the missense mutation is associated with the hair-length differences among these breeds.	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		FGF5	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Fgfr1a1	Scales (loss)	Coding, Deletion N	Cyprinus carpio common carp - (species) D	Domesticated	Candidate Gene	Rohner N; Bercsényi M; Orbán L ; et al. (2009) Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication.	GP00000312	fgfr1a Q90Z00	Morphology	deletion of 310 bp N	Cyprinus carpio common carp - (species)	Cyprinus carpio common carp - (species) D		Fgfr1a1	Cyprinus carpio common carp - (species)	Published - Accepted by Curator
Fgfr1a1	Scales (loss)	Coding, SNP	Cyprinus carpio common carp - (species) D	Domesticated	Candidate Gene	Rohner N; Bercsényi M; Orbán L ; et al. (2009) Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication.	GP00000313	fgfr1a Q90Z00	Morphology	Glu664Lys	Cyprinus carpio common carp - (species)	Cyprinus carpio common carp - (species) D		Fgfr1a1	Cyprinus carpio common carp - (species)	Published - Accepted by Curator
FGFR3	Body size (bone length)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Beever JE; Smit MA; Meyers SN ; et al. (2006) A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodyspla[...] 1 Additional References Smith LB; Dally MR; Sainz RD (2006) Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor [...]	GP00002184	FGFR3 P22607	Morphology	c.1719T>A p.V700E	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		FGFR3	Ovis aries sheep - (species)	Published - Accepted by Curator
fibrinogen-related protein 1 (FREP1)	Pathogen resistance (Plasmodium; malaria parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001465	3290292 Q5TWN1	Physiology	c.T1325A p.Q442L	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		fibrinogen-related protein 1 (FREP1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
fibrinogen-related protein 30 (FBN30)	Pathogen resistance (parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001464	1270165 Q7QIK0	Physiology	c.T28C p.F10L	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		fibrinogen-related protein 30 (FBN30)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000315	CYP75B1 Q9SD85	Morphology	-1bp at +973 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D		Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Deletion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000316	CYP75B1 Q9SD85	Morphology	-1bp at +1164 resulting in premature stop codon N	Glycine max soybean - (species)	Glycine soja (species) D		Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers; pubescence; seeds)	Coding, Indel	Glycine soja (species)	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000317	CYP75B1 Q9SD85	Morphology	a single base insertion of an adenine at position 965 as well as a single base deletion of adenine at position 973 resulting in N322K and Q324T - exact causing mutation(s) unknown	Glycine max soybean - (species)	Glycine soja (species)		Flavonoid 3'-hydroxylase (F3'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers)	Coding, Insertion N	Ipomoea purpurea common morning-glory - (species) D	Domesticated	Candidate Gene	Zufall RA; Rausher MD (2003 Nov-Dec) The genetic basis of a flower color polymorphism in the common morning glory (Ipomoea purpurea). 3 Additional References Hoshino A; Morita Y; Choi JD (2003) Spontaneous mutations of the flavonoid 3'-hydroxylase gene conferring reddish flowers in the three m[...] Zufall RA; Rausher MD (2004) Genetic changes associated with floral adaptation restrict future evolutionary potential. Des Marais DL; Rausher MD (2010) Parallel evolution at multiple levels in the origin of hummingbird pollinated flowers in Ipomoea.	GP00000319	CYP75B1 Q9SD85	Morphology	insertion of the 0.55-kb DNA transposable element Tip201 belonging to the Ac/Ds superfamily. No excision of Tip201 from the F3'H gene could be detected. Both splicing and polyadenylation patterns of the F3'H transcripts were affected by the Tip201 integration. N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		flavonoid 3'-hydroxylase (F3'H)	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (seed; pods)	Coding, Deletion N	Glycine max soybean - (species) D	Domesticated	Linkage Mapping	Toda K; Yang D; Yamanaka N ; et al. (2002) A single-base deletion in soybean flavonoid 3'-hydroxylase gene is associated with gray pubescence c[...] 1 Additional References Zabala G; Vodkin L (2003) Cloning of the pleiotropic T locus in soybean and two recessive alleles that differentially affect s[...]	GP00000321	CYP75B1 Q9SD85	Morphology	1bp deletion resulting in frameshift N	Glycine max soybean - (species)	Glycine max soybean - (species) D		flavonoid 3'-hydroxylase (F3'H)	Glycine max soybean - (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers)	Coding, SNP N	Ipomoea nil Japanese morning glory - (species) D	Domesticated	Candidate Gene	Hoshino A; Morita Y; Choi JD ; et al. (2003) Spontaneous mutations of the flavonoid 3'-hydroxylase gene conferring reddish flowers in the three m[...]	GP00002087	CYP75B1 Q9SD85	Morphology	nonsense mutation caused by a single C to T base transition generating the stop codon TGA. N	Ipomoea nil Japanese morning glory - (species)	Ipomoea nil Japanese morning glory - (species) D		flavonoid 3'-hydroxylase (F3'H)	Ipomoea nil Japanese morning glory - (species)	Published - Accepted by Curator
flavonoid 3'-hydroxylase (F3'H)	Coloration (flowers)	Coding, Insertion N	Ipomoea tricolor (species) D	Domesticated	Candidate Gene	Hoshino A; Morita Y; Choi JD ; et al. (2003) Spontaneous mutations of the flavonoid 3'-hydroxylase gene conferring reddish flowers in the three m[...]	GP00002088	CYP75B1 Q9SD85	Morphology	a single T insertion generating the stop codon TAG. The accumulation of the F3'H transcripts is drastically reduced by the nonsense-mediated RNA decay. N	Ipomoea tricolor (species)	Ipomoea tricolor (species) D		flavonoid 3'-hydroxylase (F3'H)	Ipomoea tricolor (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers; pubescence; seeds)	Coding, Insertion N	Glycine soja (species) D	Intraspecific	Candidate Gene	Guo Y; Qiu LJ (2013) Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]	GP00000322	CYP75A2 P37120	Morphology	53bp insertion at +1352 N	Glycine max soybean - (species)	Glycine soja (species) D		flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, SNP	Glycine soja (species)	Intraspecific	Linkage Mapping	Takahashi R; Dubouzet JG; Matsumura H ; et al. (2010) A new allele of flower color gene W1 encoding flavonoid 3'5'-hydroxylase is responsible for light pu[...]	GP00000323	CYP75A2 P37120	Morphology	V210M (uncertain); no expression level differences detected	Glycine soja (species)	Glycine soja (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Glycine soja (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, SNP	Pisum sativum pea - (species)	Domesticated	Candidate Gene	Moreau C; Ambrose MJ; Turner L ; et al. (2012) The B gene of pea encodes a defective flavonoid 3',5'-hydroxylase, and confers pink flower color.	GP00000326	CYP75A2 P37120	Morphology	G111E	Pisum sativum pea - (species)	Pisum sativum pea - (species)		flavonoid 3';5'-hydroxylase (F3'5'H)	Pisum sativum pea - (species)	Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)	Coloration (flowers)	Coding, Deletion N	Pisum sativum pea - (species) D	Domesticated	Linkage Mapping	Moreau C; Ambrose MJ; Turner L ; et al. (2012) The B gene of pea encodes a defective flavonoid 3',5'-hydroxylase, and confers pink flower color.	GP00000327	CYP75A2 P37120	Morphology	23bp deletion reuslting in frameshift and truncated protein N	Pisum sativum pea - (species)	Pisum sativum pea - (species) D		flavonoid 3';5'-hydroxylase (F3'5'H)	Pisum sativum pea - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000330	FLC Q9S7Q7	Physiology	Substitution creating premature Stop (codon 158) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005) FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions. 1 Additional References Ågren J; Oakley CG; Lundemo S (2017) Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]	GP00000335	FLC Q9S7Q7	Physiology	GA substitution disrupting Splice Site	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FLC (Flowering Locus C)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FLC (Flowering Locus C)	Flowering time	Coding, SNP	Capsella rubella (species)	Intraspecific	Linkage Mapping	Guo YL; Todesco M; Hagmann J ; et al. (2012) Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella[...]	GP00000337	FLC Q9S7Q7	Physiology	Splice site mutation introducing frameshift; removing the last 35 of 198 amino acids	Capsella rubella (species)	Capsella rubella (species)		FLC (Flowering Locus C)	Capsella rubella (species)	Published - Accepted by Curator
FLC-1	Flowering time	Coding, SNP	Brassica rapa field mustard - (species)	Domesticated	Linkage Mapping	Yuan YX; Wu J; Sun RF ; et al. (2009) A naturally occurring splicing site mutation in the Brassica rapa FLC1 gene is associated with varia[...]	GP00000338	FLC Q9S7Q7	Physiology	GA substitution disrupting Splice Site	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species)		FLC-1	Brassica rapa field mustard - (species)	Published - Accepted by Curator
FLC-2	Flowering time	Coding, Deletion N	Brassica oleracea wild cabbage - (species) D	Domesticated	Linkage Mapping	Okazaki K; Sakamoto K; Kikuchi R ; et al. (2007) Mapping and characterization of FLC homologs and QTL analysis of flowering time in Brassica oleracea[...]	GP00000339	FLC Q9S7Q7	Physiology	1bp deletion resulting in frameshift N	Brassica oleracea wild cabbage - (species)	Brassica oleracea wild cabbage - (species) D		FLC-2	Brassica oleracea wild cabbage - (species)	Published - Accepted by Curator
Flowering locus T (FT1)	Flowering time	Coding, Deletion N	Helianthus annuus common sunflower - (species) D	Domesticated	Linkage Mapping	Blackman BK; Strasburg JL; Raduski AR ; et al. (2010) The role of recently derived FT paralogs in sunflower domestication.	GP00000346	FT Q9SXZ2	Physiology	1bp deletion; frameshift N	Helianthus annuus common sunflower - (species)	Helianthus annuus common sunflower - (species) D		Flowering locus T (FT1)	Helianthus annuus common sunflower - (species)	Published - Accepted by Curator
FOXI3	Hair (hypotrichosis)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Drögemüller C; Karlsson EK; Hytönen MK ; et al. (2008) A mutation in hairless dogs implicates FOXI3 in ectodermal development.	GP00000351	FOXI3 B5RHS5	Morphology	Frameshift; 7-bp duplication within exon 1 N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		FOXI3	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
FoxP2	Gene expression change (transcriptional targets)	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Konopka G; Bomar JM; Winden K ; et al. (2009) Human-specific transcriptional regulation of CNS development genes by FOXP2. 1 Additional References Schreiweis C; Bornschein U; Burguière E (2014) Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural perform[...]	GP00000353	FOXP2 O15409	Behavior	2 aa changes (T303N and N325S) resulting in changes of the regulated transcriptional targets in a human neuron cell line. Speculatively; these changes could be associated with language skills but these connections with null-mutant phenotypes are dubious - whether one or both mutations are required is unknown	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D		FoxP2	Homo sapiens human - (species)	Published - Accepted by Curator
FPN2	Metal tolerance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Morrissey J; Baxter IR; Lee J ; et al. (2009) The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.	GP00000354	IREG2 F4KGN5	Physiology	1bp insertion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		FPN2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pineau C; Loubet S; Lefoulon C ; et al. (2012) Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Z[...]	GP00000355	DTX43 Q9SFB0	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		FRD3 (FERRIC REDUCTASE DEFECTIVE3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]	GP00000357	FRI P0DH90	Physiology	16bp deletion aa313-318 in exon 2 and premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Johanson U; West J; Lister C ; et al. (2000) Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000358	FRI P0DH90	Physiology	376 bp deletion and 31 bp insertion that delete amino acid 1-15 and at best produce a 45-aa protein N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Indel N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000359	FRI P0DH90	Physiology	Del 2257-2355 in exon 3; deletion of 99 bp combined with an insertion of 61 bp N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000360	FRI P0DH90	Physiology	1bp deletion at 1487 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000361	FRI P0DH90	Physiology	1bp insertion at 766 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...] 1 Additional References Shindo C; Aranzana MJ; Lister C (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000362	FRI P0DH90	Physiology	Insertion 1 bp at 1454 in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000363	FRI P0DH90	Physiology	Trp240* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Le Corre V; Roux F; Reboud X (2002) DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]	GP00000364	FRI P0DH90	Physiology	Glu361* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gazzani S; Gendall AR; Lister C ; et al. (2003) Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.	GP00000365	FRI P0DH90	Physiology	K232* in exon 1 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000366	FRI P0DH90	Physiology	deletion; E430* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000367	FRI P0DH90	Physiology	deletion of 6 amino acids; LQLDKE422-427*	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000368	FRI P0DH90	Physiology	deletion aa 1-12	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000369	FRI P0DH90	Physiology	deletion resulting in S121* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000370	FRI P0DH90	Physiology	deletion; AF375-6* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000371	FRI P0DH90	Physiology	insertion; I490* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000372	FRI P0DH90	Physiology	insertion; T258* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000373	FRI P0DH90	Physiology	Y162* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida (FRI)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Shindo C; Aranzana MJ; Lister C ; et al. (2005) Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.	GP00000374	FRI P0DH90	Physiology	K170* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida (FRI)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 1 (FRL1)	Flowering time	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000376	FRL1 Q9FFF1	Physiology	E279* in the middle of the conceptual protein sequence N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida like 1 (FRL1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Frigida like 2 (FRL2)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Schläppi MR (2006) FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]	GP00000377	FRL2 Q9C6S2	Physiology	A132P and/or L401Q	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Frigida like 2 (FRL2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...]	GP00000379	FUT2 Q10981	Physiology	9.3 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 2 Additional References Pang H; Fujitani N; Soejima M (2000) Two distinct Alu-mediated deletions of the human ABO-secretor (FUT2) locus in Samoan and Bangladeshi[...] Koda Y; Soejima M; Johnson PH (2000) An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype.	GP00000380	FUT2 Q10981	Physiology	10 kb deletion mediated by recombination between Alu sequences N	Homo sapiens human - (species)	Homo sapiens human - (species) D		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000381	FUT2 Q10981	Physiology	premature stop at codon 143: TGG>TGA N	Homo sapiens human - (species)	Homo sapiens human - (species)		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
FUT2	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kelly RJ; Rouquier S; Giorgi D ; et al. (1995) Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...] 1 Additional References Ferrer-Admetlla A; Sikora M; Laayouni H (2009) A natural history of FUT2 polymorphism in humans.	GP00000382	FUT2 Q10981	Physiology	Ile129Phe	Homo sapiens human - (species)	Homo sapiens human - (species)		FUT2	Homo sapiens human - (species)	Published - Accepted by Curator
GCNF (NR6A1)	Vertebrae number	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Mikawa S; Morozumi T; Shimanuki S ; et al. (2007) Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan n[...]	GP00000386	Nr6a1 Q64249	Morphology	Pro192Leu	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		GCNF (NR6A1)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Silva BD; Castro EA; Souza CJ ; et al. (2011) A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increas[...]	GP00000390	GDF9 O60383	Physiology	F345C	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Linkage Mapping	Nicol L; Bishop SC; Pong-Wong R ; et al. (2009) Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility i[...]	GP00000391	GDF9 O60383	Physiology	g.41841117A>C c.1279A>C p.S427R	Ovis aries sheep - (species)	Ovis aries sheep - (species)		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Våge DI; Husdal M; Kent MP ; et al. (2013) A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter siz[...] 1 Additional References Mullen MP; Hanrahan JP (2014) Direct evidence on the contribution of a missense mutation in GDF9 to variation in ovulation rate of[...]	GP00002186	GDF9 O60383	Physiology	g.41841285G>A c.1111G>A p.V371M	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004) Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]	GP00002187	GDF9 O60383	Physiology	g.41841212C>T c.1184C>T p.S395F	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
GDF9	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Souza CJ; McNeilly AS; Benavides MV ; et al. (2014) Mutation in the protease cleavage site of GDF9 increases ovulation rate and litter size in heterozyg[...]	GP00002188	GDF9 O60383	Physiology	g.41841453C>T c.943C>T p.R315C	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		GDF9	Ovis aries sheep - (species)	Published - Accepted by Curator
Ge-1	Pathogen resistance (sigma virus)	Coding, Deletion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Cao C; Magwire MM; Bayer F ; et al. (2016) A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rh[...]	GP00001993	Ge-1 Q9VKK1	Physiology	78bp deletion ( 2L:11097925 ..11098002 in both Release 5 and Release 6 coordinates) in the fifth exon of Ge-1 which reduces the length of the serine-rich linker region by 26 amino acid residues	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Ge-1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
GH	Body size (dwarfism)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	McCormack BL; Chase CC; Olson TA ; et al. (2009) A miniature condition in Brahman cattle is associated with a single nucleotide mutation within the g[...]	GP00002037	GH1 P01241	Morphology	g.48768780C>T c.593C>T p.T198M	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		GH	Bos taurus cattle - (species)	Published - Accepted by Curator
GIGANTEA	Photoperiod response Circadian rhythm	Coding, SNP	Brassica rapa field mustard - (species)	Domesticated	Linkage Mapping	Xie Q; Lou P; Hermand V ; et al. (2015) Allelic polymorphism of GIGANTEA is responsible for naturally occurring variation in circadian perio[...]	GP00000396	GI Q9SQI2	Physiology Physiology	Ser264Ala	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species)		GIGANTEA	Brassica rapa field mustard - (species)	Published - Accepted by Curator
GL3.1	Grain size	2 Mutations: Coding SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Qi P; Lin YS; Song XJ ; et al. (2012) The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;[...]	GP00000397	GL3 Q9FN69	Morphology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		GL3.1	Oryza sativa rice - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001239	GL1 P27900	Morphology	S92F	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001240	GL1 P27900	Morphology	+1bp at position 352 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
GLABROUS1	Trichome density (leaf)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...] 1 Additional References Hauser MT; Harr B; Schlötterer C (2001) Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]	GP00001241	GL1 P27900	Morphology	-1bp at position 203 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		GLABROUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
glb-5	CO2 avoidance Aggregation behavior	Coding, Indel N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	McGrath PT; Rockman MV; Zimmer M ; et al. (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] 2 Additional References Bendesky A; Pitts J; Rockman MV (2012) Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...] Persson A; Gross E; Laurent P (2009) Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.	GP00000399	glb-5 A3RMS5	Behavior Behavior	765bp insertion/duplication resulting in a truncation of the last 179 amino acids of the protein and the inclusion of 40 different residues N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		glb-5	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLC-1	Xenobiotic resistance (antihelmintics)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Ghosh R; Andersen EC; Shapiro JA ; et al. (2012) Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.	GP00000400	glc-1 G5EBR3	Physiology	4aa deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		GLC-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
GLO(T)	Flower morphology (anther elevation)	Coding, Insertion N	Primula vulgaris (species) D	Intraspecific	Linkage Mapping	Li J; Cocker JM; Wright J ; et al. (2016) Genetic architecture and evolution of the S locus supergene in Primula vulgaris.	GP00001393	GLO Q03378	Morphology	A 2.5 kb retrotransposon in exon 2 severely truncates the protein N	Primula vulgaris (species)	Primula vulgaris (species) D		GLO(T)	Primula vulgaris (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000401	G6PD P11413	Physiology	Ser188Phe C>T	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Louicharoen C; Patin E; Paul R ; et al. (2009) Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.	GP00000402	G6PD P11413	Physiology	Ser163Gly	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)	Pathogen resistance (malaria)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001) Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]	GP00000403	G6PD P11413	Physiology	Val68Met G>A at nucleotide position 376 in exon 5 - OMIM code +305900.0002	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-6-phosphate dehydrogenase (G6PD)	Homo sapiens human - (species)	Published - Accepted by Curator
Glucose-dependent insulinotropic polypeptide	Glycemia Adipolysis rate	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Chang CL; Cai JJ; Lo C ; et al. (2011) Adaptive selection of an incretin gene in Eurasian populations.	GP00000404	GIP P09681	Physiology Physiology	Ser103Gly	Homo sapiens human - (species)	Homo sapiens human - (species) D		Glucose-dependent insulinotropic polypeptide	Homo sapiens human - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; abamectin)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Dermauw W; Ilias A; Riga M ; et al. (2012) The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: implications for acaricide[...]	GP00002601	GluClalpha Q94900	Physiology	G326E inTu_GluCl3	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		glutamate-gated chloride channel (GluCl)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; nodulisporic acid)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Kane NS; Hirschberg B; Qian S ; et al. (2000) Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasit[...]	GP00002602	GluClalpha Q94900	Physiology	P299S	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		glutamate-gated chloride channel (GluCl)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; ivermectin)	Coding, SNP	Cooperia oncophora (species) D	Intraspecific	Candidate Gene	Njue AI; Hayashi J; Kinne L ; et al. (2004) Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits [...]	GP00002603	GluClalpha Q94900	Physiology	E114G V235A L256F in the GluCla3 ortholog and V60A R101Hin the GluClb ortholog.	Cooperia oncophora (species)	Cooperia oncophora (species) D		glutamate-gated chloride channel (GluCl)	Cooperia oncophora (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; ivermectin)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Kwon DH; Yoon KS; Clark JM ; et al. (2010) A point mutation in a glutamate-gated chloride channel confers abamectin resistance in the two-spott[...] 1 Additional References Dermauw W; Ilias A; Riga M (2012) The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: implications for acaricide[...]	GP00002604	GluClalpha Q94900	Physiology	G323D in the highly conserved TM2 region of Tu_GluCl	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		glutamate-gated chloride channel (GluCl)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)	Xenobiotic resistance (insecticide; abamectin)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang X; Wang R; Yang Y ; et al. (2016) A point mutation in the glutamate-gated chloride channel of Plutella xylostella is associated with r[...]	GP00002634	GluClalpha Q94900	Physiology	A309V	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		glutamate-gated chloride channel (GluCl)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
GmHs1-1 (Glyma02g43700.1)	Seed hardness Seed coat permeability	Coding, SNP	Glycine max soybean - (species) D	Domesticated	Linkage Mapping	Sun L; Miao Z; Cai C ; et al. (2015) GmHs1-1, encoding a calcineurin-like protein, controls hard-seededness in soybean.	GP00001543	Hs1 I1JIK2	Physiology Physiology	C>T p.Thr>Met predicted to affect the alpha-helix of the protein	Glycine soja (species)	Glycine max soybean - (species) D		GmHs1-1 (Glyma02g43700.1)	Glycine max soybean - (species)	Published - Accepted by Curator
GPA1	Pheromone response Cell elongation	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Yvert G; Brem RB; Whittle J ; et al. (2003) Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. 1 Additional References Nogami S; Ohya Y; Yvert G (2007) Genetic complexity and quantitative trait loci mapping of yeast morphological traits.	GP00000410	GPA1 P08539	Physiology Physiology	Ser469Ile	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		GPA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Insertion	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001669	GPRC6A Q5T6X5	Physiology	insertion of KL (6 bp) resulting in sequence KGKKLY in the third intracellular loop (ICL3) with surface expression and function greatly reduced	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Deletion	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001670	GPRC6A Q5T6X5	Physiology	KGRKLP>KGRK-Y in the third intracellular loop (ICL3) with surface expression and function greatly reduced	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001671	GPRC6A Q5T6X5	Physiology	KGRKLP>KGK--Y in the third intracellular loop (ICL3) responsible for the intracellular retention and lack of function N	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
GPRC6A	Cell signaling (membrane receptor activity)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Jørgensen S; Have CT; Underwood CR ; et al. (2017) Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]	GP00001672	GPRC6A Q5T6X5	Physiology	C>T (aa57) located in the first exon resulting in a premature Stop-codon and non-functional protein N	Homo sapiens human - (species)	Homo sapiens human - (species) D		GPRC6A	Homo sapiens human - (species)	Published - Accepted by Curator
Gr5a	Taste sensitivity (sugar; trehalose)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Ueno K; Ohta M; Morita H ; et al. (2001) Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory rec[...] 2 Additional References Tanimura Teiichi; Isono Kunio; Takamura Tsuguhiko (1982 ) Genetic dimorphism in the taste sensitivity to trehalose inDrosophila melanogaster Inomata N; Goto H; Itoh M (2004) A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sen[...]	GP00001997	Gr5a Q9W497	Physiology	Nucleotide change: A5681571G - Amino acid change: T218A	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Gr5a	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Green-sensitive opsin (RH2)	Color vision (blue shift)	Coding, SNP	Thunnus orientalis Pacific bluefin tuna - (species) D	Intergeneric or Higher	Candidate Gene	Nakamura Y; Mori K; Saitoh K ; et al. (2013) Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna[...]	GP00001469	opn1mw1 Q9W6A5	Physiology	p.E122Q (G>C) in four of five genes	Percomorphaceae (no rank)	Thunnus orientalis Pacific bluefin tuna - (species) D		Green-sensitive opsin (RH2)	Thunnus orientalis Pacific bluefin tuna - (species)	Published - Accepted by Curator
Growth Hormone Receptor	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Viitala S; Szyda J; Blott S ; et al. (2006) The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...] 1 Additional References Rahmatalla SA; Müller U; Strucken EM (2011) The F279Y polymorphism of the GHR gene and its relation to milk production and somatic cell score in[...]	GP00000416	Ghr P16882	Physiology	Phe279Tyr	Bos taurus cattle - (species)	Bos taurus cattle - (species)		Growth Hormone Receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
Growth Hormone Receptor (GHR)	Body size (height)	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Association Mapping	Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015) Height-reducing variants and selection for short stature in Sardinia.	GP00000415	GHR P10912	Morphology	Arg61* N	Homo sapiens human - (species)	Homo sapiens human - (species)		Growth Hormone Receptor (GHR)	Homo sapiens human - (species)	Published - Accepted by Curator
growth hormone receptor (GHR)	Body size (weight)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Rimbault M; Beale HC; Schoenebeck JJ ; et al. (2013) Derived variants at six genes explain nearly half of size reduction in dog breeds.	GP00001475	GHR Q9TU69	Morphology	G>A in exon 5 p.E191K in extracellular domain	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		growth hormone receptor (GHR)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
growth hormone receptor (GHR)	Body size (weight)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Rimbault M; Beale HC; Schoenebeck JJ ; et al. (2013) Derived variants at six genes explain nearly half of size reduction in dog breeds.	GP00001476	GHR Q9TU69	Morphology	C>T in exon 5 p.P177L in extracellular domain	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		growth hormone receptor (GHR)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Growth Hormone Receptor (GHR)	Body size (dwarfism)	Coding, Deletion N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Agarwal SK; Cogburn LA; Burnside J (1994) Dysfunctional growth hormone receptor in a strain of sex-linked dwarf chicken: evidence for a mutati[...]	GP00002189	GHR P10912	Morphology	deletion of 1773 bp in the 3' end of the coding region N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Growth Hormone Receptor (GHR)	Gallus gallus chicken - (species)	Published - Accepted by Curator
GS3	Grain size	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Fan C; Xing Y; Mao H ; et al. (2006) GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, en[...] 1 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000417	GS3 C6L686	Morphology	C55*;TGC>TGA causing a 178-aa truncation in the C-terminus of the predicted protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		GS3	Oryza sativa rice - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Anopheles funestus African malaria mosquito - (species)	Intraspecific	Candidate Gene	Riveron JM; Yunta C; Ibrahim SS ; et al. (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002455	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species)		GSTe	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera litura (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002456	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera litura (species)	Spodoptera litura (species)		GSTe	Spodoptera litura (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera frugiperda fall armyworm - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002457	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species)		GSTe	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera exigua beet armyworm - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002458	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species)		GSTe	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Spodoptera littoralis African cotton leafworm - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002459	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Spodoptera littoralis African cotton leafworm - (species)	Spodoptera littoralis African cotton leafworm - (species)		GSTe	Spodoptera littoralis African cotton leafworm - (species)	Published - Accepted by Curator
GSTe	Xenobiotic resistance (insecticide; DDT)	Coding, SNP	Anopheles funestus African malaria mosquito - (species)	Intraspecific	Candidate Gene	Hilliou F; Chertemps T; Maïbèche M ; et al. (2021) Resistance in the Genus Spodoptera: Key Insect Detoxification Genes. 1 Additional References Riveron JM; Yunta C; Ibrahim SS (2014) A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]	GP00002460	GstE2 Q7JYZ9	Physiology	L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species)		GSTe	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000420	Gulo P58710	Physiology	pseudogenization involving invalidating mutations at most exons N	Mammalia mammals - (class)	Cavia porcellus domestic guinea pig - (species)		Gulo	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Myotis lucifugus little brown bat - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000421	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Myotis lucifugus little brown bat - (species)		Gulo	Myotis lucifugus little brown bat - (species)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Primates (order)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000422	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Primates (order)		Gulo	Primates (order)	Published - Accepted by Curator
Gulo	Vitamin-C synthesis (loss)	Coding, Complex Change N	Pteropus vampyrus large flying fox - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000423	Gulo P58710	Physiology	pseudogenization N	Mammalia mammals - (class)	Pteropus vampyrus large flying fox - (species)		Gulo	Pteropus vampyrus large flying fox - (species)	Published - Accepted by Curator
GW2	Grain size	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Song XJ; Huang W; Shi M ; et al. (2007) A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase.	GP00000424	GW2 A4GWX9	Morphology	1bp deletion resulting in a premature stop codon in exon 4; the premature stop codon led to truncation of 310 amino acid residues N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		GW2	Oryza sativa rice - (species)	Published - Accepted by Curator
GW2	Grain size	Coding, Insertion N	Triticum aestivum bread wheat - (species) D	Domesticated	Linkage Mapping	Yang Z; Bai Z; Li X ; et al. (2012) SNP identification and allelic-specific PCR markers development for TaGW2, a gene linked to wheat ke[...]	GP00000425	GW2 A4GWX9	Morphology	1bp insertion resulting in premature stop codon N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species) D		GW2	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000426	ABCA2 A0A0S0G7V0	Physiology	Pro53* (161T>A) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...] 2 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000427	ABCA2 A0A0S0G7V0	Physiology	10kb deletion N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000428	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Yang Y; Chen H; Wu S ; et al. (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...] 1 Additional References Zhao J; Jin L; Yang Y (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]	GP00000429	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000430	ABCA2 A0A0S0G7V0	Physiology	Insertion of an incomplete RNA transposon (1498bp) N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000431	ABCA2 A0A0S0G7V0	Physiology	Insertion of a DNA transposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000432	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
Ha_BtR	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Zhao J; Jin L; Yang Y ; et al. (2010) Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...] 1 Additional References Yang Y; Chen H; Wu S (2006) Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]	GP00000433	ABCA2 A0A0S0G7V0	Physiology	Insertion of a LTR retrotransposon N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		Ha_BtR	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
HAC1 (=ATQ1)	Xenobiotic resistance (soil contamination; arsenate)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Chen Y; Chen J ; et al. (2014) Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]	GP00000435	HAC1 Q9C5X9	Physiology	1bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		HAC1 (=ATQ1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Doi K; Izawa T; Fuse T ; et al. (2004) Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-[...]	GP00000439	HD1 Q9FDX8	Physiology	Retro-element-like inserted in exon 2 N	Oryza glaberrima African rice - (species)	Oryza sativa rice - (species) D		Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Yano M; Katayose Y; Ashikari M ; et al. (2000) Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Ara[...] 1 Additional References Takahashi Y; Teshima KM; Yokoi S (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00000441	HD1 Q9FDX8	Physiology	2bp deletion in the putative exon 2 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001722	HD1 Q9FDX8	Physiology	1bp deletion at position 606 ; presumptive protein truncated N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001723	HD1 Q9FDX8	Physiology	1bp deletion at position 321 ; presumptive protein truncated N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001724	HD1 Q9FDX8	Physiology	4bp deletion at position 1089 ; presumptive protein truncated N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd1	Flowering time	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Takahashi Y; Teshima KM; Yokoi S ; et al. (2009) Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]	GP00001725	HD1 Q9FDX8	Physiology	C to T – stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Hd1	Oryza sativa rice - (species)	Published - Accepted by Curator
Hd6a	Flowering time	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Takahashi Y; Shomura A; Sasaki T ; et al. (2001) Hd6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the alpha subunit [...]	GP00000442	HD6 Q9AR27	Physiology	K91*; AAG>TAG N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Hd6a	Oryza sativa rice - (species)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, Deletion N	Sorghum virgatum (species) D	Domesticated	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001408	CO Q39057	Physiology	5bp deletion in the coding sequence leading to gene frameshift N	Sorghum bicolor sorghum - (species)	Sorghum virgatum (species) D		Heading Date 1 (HD1)	Sorghum virgatum (species)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, Deletion N	Sorghum (genus) D	Interspecific	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001409	CO Q39057	Physiology	80bp deletion in first exon leading to gene frameshift N	Sorghum (genus)	Sorghum (genus) D		Heading Date 1 (HD1)	Sorghum (genus)	Published - Accepted by Curator
Heading Date 1 (HD1)	Flowering time	Coding, SNP N	Setaria italica foxtail millet - (species) D	Domesticated	Association Mapping	Liu H; Liu H; Zhou L ; et al. (2015) Parallel Domestication of the Heading Date 1 Gene in Cereals.	GP00001410	CO Q39057	Physiology	splicing variant at position 787 GT>AT resulting in a splicing shift to position 754 introducing a deletion of 33 bp in the transcript and 11 aa in the protein N	Setaria italica foxtail millet - (species)	Setaria italica foxtail millet - (species) D		Heading Date 1 (HD1)	Setaria italica foxtail millet - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	2 Mutations: Coding SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000443	HMA3 P0CW78	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Chao DY; Silva A; Baxter I ; et al. (2012) Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]	GP00000444	HMA3 P0CW78	Physiology	1-bp deletion resulting in a premature stop codon resulting in hypofunctional transporter. This is a high-frequency allele; suggesting the hyper-functional alleles are only selected in Cd-rich soils N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase3 (HMA3)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase3 (HMA3)	Metal tolerance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Ueno D; Yamaji N; Kono I ; et al. (2010) Gene limiting cadmium accumulation in rice.	GP00000445	HMA3 P0CW78	Physiology	H80R	Oryza sativa rice - (species)	Oryza sativa rice - (species)		heavy metal atpase3 (HMA3)	Oryza sativa rice - (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000450	HMA5 Q9SH30	Physiology	P626L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
heavy metal atpase5 (HMA5)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kobayashi Y; Kuroda K; Kimura K ; et al. (2008) Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]	GP00000451	HMA5 Q9SH30	Physiology	N923T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		heavy metal atpase5 (HMA5)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000452	hecw-1 G5EEJ0	Behavior	Y322C	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
HECW-1	Pathogen avoidance	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Chang HC; Paek J; Kim DH (2011) Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.	GP00000453	hecw-1 G5EEJ0	Behavior	Q325P	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		HECW-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
hemoglobin; HBA	Hypoxia response	Coding, SNP	Lama (genus)	Interspecific	Candidate Gene	Kleinschmidt T; März J; Jürgens KD ; et al. (1986) Interaction of allosteric effectors with alpha-globin chains and high altitude respiration of mammal[...]	GP00000454	HBA1 P69905	Physiology	Asp122His	Mammalia mammals - (class)	Lama (genus)		hemoglobin; HBA	Lama (genus)	Published - Accepted by Curator
hemoglobin; HBA and HBB	Hypoxia response	Coding, SNP	Crocodylus niloticus Nile crocodile - (species)	Intergeneric or Higher	Candidate Gene	Komiyama NH; Miyazaki G; Tame J ; et al. (1995) Transplanting a unique allosteric effect from crocodile into human haemoglobin.	GP00000455	HBA1 P69905	Physiology	No more than 12 amino acid substitutions required for providing crocodile-like properties in engineered human Hb - effect of single amino acid changes not tested	Homo sapiens human - (species)	Crocodylus niloticus Nile crocodile - (species)		hemoglobin; HBA and HBB	Crocodylus niloticus Nile crocodile - (species)	Published - Accepted by Curator
hemoglobin; HBA-T1 and T2 paralogues	Hypoxia response	5 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Sabatino SJ; Hoffmann FG ; et al. (2007) The molecular basis of high-altitude adaptation in deer mice. 2 Additional References Storz JF; Kelly JK (2008) Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights [...] Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000456	HBA1 P69905	Physiology	5 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		hemoglobin; HBA-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas cyanoptera cinnamon teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000457	HBA1 P69905	Physiology	Asn9Ser	Anas cyanoptera cinnamon teal - (species)	Anas cyanoptera cinnamon teal - (species) D		hemoglobin; HBA2	Anas cyanoptera cinnamon teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000458	HBA1 P69905	Physiology	Ala77Thr	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000459	HBAD P02001	Physiology	Ser130Phe	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBA2	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000460	HBA1 P69905	Physiology	Ala77Thr	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000461	HBAD P02001	Physiology	Val96Ala	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBA2	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Anser indicus bar-headed goose - (species) D	Interspecific	Candidate Gene	Jessen TH; Weber RE; Fermi G ; et al. (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...] 2 Additional References McCracken KG; Barger CP; Bulgarella M (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. McCracken KG; Barger CP; Sorenson MD (2010) Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin gen[...]	GP00000462	HBA1 P69905	Physiology	Pro119Ala	Anser anser domestic goose - (species)	Anser indicus bar-headed goose - (species) D		hemoglobin; HBA2	Anser indicus bar-headed goose - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000463	HBA1 P69905	Physiology	Ala5Thr	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBA2	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	Coding, SNP	Merganetta armata (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000464	HBA1 P69905	Physiology	Ala77Thr	Merganetta armata (species)	Merganetta armata (species) D		hemoglobin; HBA2	Merganetta armata (species)	Published - Accepted by Curator
hemoglobin; HBA2	Hypoxia response	2 Mutations: Coding SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000465	HBAD P02001	Physiology	2 mutations	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBA2	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Pathogen resistance (Plasmodium; malaria parasite)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Jallow M; Teo YY; Small KS ; et al. (2009) Genome-wide and fine-resolution association analysis of malaria in West Africa.	GP00000466	HBB P68871	Physiology	Glu6Val	Homo sapiens human - (species)	Homo sapiens human - (species) D		hemoglobin; HBB	Homo sapiens human - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas flavirostris Yellow-billed teal - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000467	HBB P68871	Physiology	2 mutations	Anas flavirostris Yellow-billed teal - (species)	Anas flavirostris Yellow-billed teal - (species) D		hemoglobin; HBB	Anas flavirostris Yellow-billed teal - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas georgica yellow-billed pintail - (species) D	Intraspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. 1 Additional References Natarajan C; Projecto-Garcia J; Moriyama H (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000468	HBB P68871	Physiology	2 mutations	Anas georgica yellow-billed pintail - (species)	Anas georgica yellow-billed pintail - (species) D		hemoglobin; HBB	Anas georgica yellow-billed pintail - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Anas puna (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000469	HBB P68871	Physiology	2 mutations	Anas ducks - (genus)	Anas puna (species) D		hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	2 Mutations: Coding SNP	Lophonetta specularioides crested duck - (species) D	Interspecific	Candidate Gene	McCracken KG; Barger CP; Bulgarella M ; et al. (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.	GP00000470	HBB P68871	Physiology	2 mutations	Anatidae waterfowl - (family)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Anas puna (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000471	HBB P68871	Physiology	Asp94Glu	Anas versicolor (species)	Anas puna (species) D		hemoglobin; HBB	Anas puna (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Lophonetta specularioides crested duck - (species) D	Intraspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000472	HBB P68871	Physiology	Asp94Glu	Lophonetta specularioides crested duck - (species)	Lophonetta specularioides crested duck - (species) D		hemoglobin; HBB	Lophonetta specularioides crested duck - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Jessen TH; Weber RE; Fermi G ; et al. (1991) Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...] 2 Additional References McCracken KG; Barger CP; Bulgarella M (2009) Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl. McCracken KG; Barger CP; Sorenson MD (2010) Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin gen[...]	GP00000473	HBB P68871	Physiology	Leu55Ser	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	Coding, SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000474	HBB P68871	Physiology	Ala86Ser	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB	Hypoxia response	3 Mutations: Coding SNP	Chloephaga melanoptera Andean goose - (species) D	Interspecific	Candidate Gene	Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015) Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]	GP00000475	HBA1 P69905	Physiology	3 mutations	Neochen jubata Orinoco goose - (species)	Chloephaga melanoptera Andean goose - (species) D		hemoglobin; HBB	Chloephaga melanoptera Andean goose - (species)	Published - Accepted by Curator
hemoglobin; HBB-T1 and T2 paralogues	Hypoxia response	4 Mutations: Coding SNP	Peromyscus maniculatus North American deer mouse - (species) D	Intraspecific	Candidate Gene	Storz JF; Runck AM; Sabatino SJ ; et al. (2009) Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer [...] 1 Additional References Natarajan C; Inoguchi N; Weber RE (2013) Epistasis among adaptive mutations in deer mouse hemoglobin.	GP00000476	HBB P68871	Physiology	4 mutations	Peromyscus maniculatus North American deer mouse - (species)	Peromyscus maniculatus North American deer mouse - (species) D		hemoglobin; HBB-T1 and T2 paralogues	Peromyscus maniculatus North American deer mouse - (species)	Published - Accepted by Curator
hemoglobin; HBB/HBD fusion gene	Temperature tolerance (cold)	3 Mutations: Coding SNP	Mammuthus primigenius woolly mammoth - (species)	Intergeneric or Higher	Candidate Gene	Campbell KL; Roberts JE; Watson LN ; et al. (2010) Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance[...]	GP00000477	HBB P68871	Physiology	3 mutations	Elephantidae elephants - (family)	Mammuthus primigenius woolly mammoth - (species)		hemoglobin; HBB/HBD fusion gene	Mammuthus primigenius woolly mammoth - (species)	Published - Accepted by Curator
HES7	Organ size (tail; short)	Coding, SNP	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Lyons LA; Creighton EK; Alhaddad H ; et al. (2016) Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentatio[...] 1 Additional References Xu X; Sun X; Hu XS (2016) Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian [...]	GP00002190	HES7 Q9BYE0	Morphology	g.2819475A>G c.5A>G p.V2A	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		HES7	Felis catus domestic cat - (species)	Published - Accepted by Curator
HM1 = HC toxin reductase (HCTR) [possible pseudo-replicate from other Maize entry]	Pathogen resistance	Coding, Insertion N	Zea mays (species) D	Domesticated	Linkage Mapping	Johal GS; Briggs SP (1992) Reductase activity encoded by the HM1 disease resistance gene in maize. 1 Additional References Multani DS; Meeley RB; Paterson AH (1998) Plant-pathogen microevolution: molecular basis for the origin of a fungal disease in maize.	GP00000481	hm1 O49163	Physiology	256-bp transposable element insertion in exon 4 N	Zea mays (species)	Zea mays (species) D		HM1 = HC toxin reductase (HCTR) [possible pseudo-replicate from other Maize entry]	Zea mays (species)	Published - Accepted by Curator
HM2 = HC toxin reductase (HCTR)	Pathogen resistance	Coding, Deletion N	Zea mays (species) D	Domesticated	Candidate Gene	Chintamanani S; Multani DS; Ruess H ; et al. (2008) Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred b[...]	GP00000482	hm2 B8QWA3	Physiology	deletion from exon 2 (nucleotide 420) to beyond the confines of the hm2 gene into an unknown genomic region. N	Zea mays (species)	Zea mays (species) D		HM2 = HC toxin reductase (HCTR)	Zea mays (species)	Published - Accepted by Curator
HM2 = HC toxin reductase (HCTR)	Pathogen resistance	Coding, Insertion N	Zea mays (species) D	Domesticated	Candidate Gene	Chintamanani S; Multani DS; Ruess H ; et al. (2008) Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred b[...]	GP00000483	hm2 B8QWA3	Physiology	8-bp insertion in exon 1 that disrupt the reading frame and introduces a stop codon shortly after the beginning of the gene N	Zea mays (species)	Zea mays (species) D		HM2 = HC toxin reductase (HCTR)	Zea mays (species)	Published - Accepted by Curator
HMGA2	Body size (dwarfism) Cranio-facial morphology	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Association Mapping	Carneiro M; Hu D; Archer J ; et al. (2017) Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA[...]	GP00001675	HMGA2 P52926	Morphology Morphology	deletion of 12.1 kb overlapping the promoter region and first three exons leading to inactivation of the gene. The 5'-end of this deletion overlaps a CSINE2 element N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		HMGA2	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
HP1D2	Sex determination (sex ratio distortion)	Coding, Deletion N	Drosophila simulans (species) D	Intraspecific	Linkage Mapping	Helleu Q; Gérard PR; Dubruille R ; et al. (2016) Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.	GP00001467	HP1D2 B4R6K0	Physiology	deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N	Drosophila simulans (species)	Drosophila simulans (species) D		HP1D2	Drosophila simulans (species)	Published - Accepted by Curator
Hps4	Coloration (albinism)	Coding, Deletion N	Ictalurus punctatus channel catfish - (species) D	Intraspecific	Association Mapping	Li Y; Geng X; Bao L ; et al. (2017) A deletion in the Hermansky-Pudlak syndrome 4 (Hps4) gene appears to be responsible for albinism in [...]	GP00002122	Hps4 Q99KG7	Morphology	A 99‐bp deletion was identified spanning intron 2 and exon 3 junction of the Hps4 gene N	Ictalurus punctatus channel catfish - (species)	Ictalurus punctatus channel catfish - (species) D		Hps4	Ictalurus punctatus channel catfish - (species)	Published - Accepted by Curator
HUA2	Flowering time Shoot morphology	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Wang Q; Sajja U; Rosloski S ; et al. (2007) HUA2 caused natural variation in shoot morphology of A. thaliana.	GP00000491	HUA2 Q9XER9	Physiology Morphology	K525E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
HUA2	Flowering time Coloration (temperature-dependent)	Coding, Unknown N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ilk N; Ding J; Ihnatowicz A ; et al. (2015) Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...] 1 Additional References Doyle MR; Bizzell CM; Keller MR (2005) HUA2 is required for the expression of floral repressors in Arabidopsis thaliana.	GP00001230	HUA2 Q9XER9	Physiology Morphology	Premature stop codon resulting in truncation of 290 C-terminal amino-acids (hua-2-5 Ler allele) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		HUA2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Human Leukocyte Antigen-B (HLA-B)	Pathogen resistance (HIV control)	5 Mutations: Coding SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	; Pereyra F; Jia X ; et al. (2010) The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.	GP00000492	HLA-B P01889	Physiology	5 mutations	Homo sapiens human - (species)	Homo sapiens human - (species)		Human Leukocyte Antigen-B (HLA-B)	Homo sapiens human - (species)	Published - Accepted by Curator
HvbHLH1	Coloration	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Association Mapping	Cockram J; White J; Zuluaga DL ; et al. (2010) Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genom[...]	GP00000493	bHLH1 E5FCX3	Morphology	16bp deletion resulting in premature stop codon N	Hordeum vulgare (species)	Hordeum vulgare (species) D		HvbHLH1	Hordeum vulgare (species)	Published - Accepted by Curator
ICARUS1	Plant growth (leaf morphology ; temperature-dependent) Hypersensitive to DNA damage	2 Mutations: Coding N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Zhu W; Ausin I; Seleznev A ; et al. (2015) Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at[...]	GP00002066	ICA1 A0A0F7PXK5	Physiology Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		ICARUS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
IME1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00000498	IME1 P21190	Physiology	L325M and/or 1bp synonymous substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		IME1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Inhibitor of DNA binding 3 (id3)	Lifespan	Coding, Deletion	Nothobranchius pienaari (species) D	Interspecific	Association Mapping	Reichwald K; Petzold A; Koch P ; et al. (2015) Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.	GP00001677	ID3 Q02535	Physiology	One evolutionarily conserved aa (E) is deleted in id3 C-terminus	Nothobranchius rachovii bluefin notho - (species)	Nothobranchius pienaari (species) D		Inhibitor of DNA binding 3 (id3)	Nothobranchius pienaari (species)	Published - Accepted by Curator
InR	Fertility Developmental time Body size Stress response Lifespan	Coding, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Paaby AB; Bergland AO; Behrman EL ; et al. (2014) A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-[...] 1 Additional References Paaby AB; Blacket MJ; Hoffmann AA (2010) Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independ[...]	GP00002663	InR P09208	Morphology Morphology; Physiology Physiology Physiology Physiology	Deletion of 9 nucleotides in the first exon. The two alleles differ by presence/absence of the three amino acids QHH.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		InR	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Insulin-like growth factor receptor 1 (IGF1R)	Body size (weight)	Coding, SNP	Homo sapiens human - (species) D	Domesticated	Candidate Gene	Rimbault M; Beale HC; Schoenebeck JJ ; et al. (2013) Derived variants at six genes explain nearly half of size reduction in dog breeds.	GP00001479	IGF1R P08069	Morphology	G>A p.R204H in exon 2	Canis lupus gray wolf - (species)	Homo sapiens human - (species) D		Insulin-like growth factor receptor 1 (IGF1R)	Homo sapiens human - (species)	Published - Accepted by Curator
Ir75a	Olfaction	Coding, SNP	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Prieto-Godino LL; Rytz R; Bargeton B ; et al. (2016) Olfactory receptor pseudo-pseudogenes.	GP00001701	Ir75a Q9VVL1	Physiology	T289S and/or Q536K and/or F538L - introduction of these three amino acid changes in the D. melanogaster protein is sufficient to confer response indistinguishable from the one of D. sechellia	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D		Ir75a	Drosophila sechellia (species)	Published - Accepted by Curator
Ir75b	Olfaction Oviposition site preference	Coding, SNP	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Prieto-Godino LL; Rytz R; Cruchet S ; et al. (2017) Evolution of Acid-Sensing Olfactory Circuits in Drosophilids. 2 Additional References Álvarez-Ocaña R; Shahandeh MP; Ray V (2023) Odor-regulated oviposition behavior in an ecological specialist. Prieto-Godino LL; Schmidt HR; Benton R (2021) Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity.	GP00001702	Ir75b B7Z069	Physiology Behavior; Physiology	T523S in the LBD domain - caused by C1568G	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D		Ir75b	Drosophila sechellia (species)	Published - Accepted by Curator
IRA1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001709	IRA1 P18963	Physiology	Arg1583Lys (G>A at position 521875 according to Table 1) - AGR to AAR position 521875	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		IRA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
IRA2	Growth rate (environment-dependent)	Coding, Unknown	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Smith EN; Kruglyak L (2008) Gene-environment interaction in yeast gene expression.	GP00000505	IRA2 P19158	Physiology	unknown	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		IRA2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Isocitrate dehydrogenase (NADP) (IDH)	Temperature tolerance (temperature range)	2 Mutations: Coding SNP	Mytilus trossulus common blue mussel - (species)	Interspecific	Candidate Gene	Lockwood BL; Somero GN (2012) Functional determinants of temperature adaptation in enzymes of cold- versus warm-adapted mussels (G[...]	GP00000506	I1VYX2	Physiology	2 mutations	Mytilus galloprovincialis Mediterranean mussel - (species)	Mytilus trossulus common blue mussel - (species)		Isocitrate dehydrogenase (NADP) (IDH)	Mytilus trossulus common blue mussel - (species)	Published - Accepted by Curator
KAI2 paralogs	Seed dormancy (strigolactone responsiveness)	Coding, Unknown	Orobancheae (tribe) D	Intergeneric or Higher	Candidate Gene	Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015) PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]	GP00000509	D14 Q10QA5	Physiology	Ligand-binding pocket tuning in duplicated gene	Orobanchaceae (family)	Orobancheae (tribe) D		KAI2 paralogs	Orobancheae (tribe)	Published - Accepted by Curator
KCS18	Oil composition	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Jasinski S; Lécureuil A; Miquel M ; et al. (2012) Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]	GP00000512	FAE1 Q38860	Physiology	L407V N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		KCS18	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001510	PF3D7_1343700 Q8IDQ2	Physiology	D353Y affecting the BTB/POZ domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001511	PF3D7_1343700 Q8IDQ2	Physiology	P441L affecting the BTB/POZ domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001512	PF3D7_1343700 Q8IDQ2	Physiology	F446I affecting the encoded propeller and BTB/POZ domains	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001513	PF3D7_1343700 Q8IDQ2	Physiology	G449A affecting the encoded propeller and BTB/POZ domains	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001514	PF3D7_1343700 Q8IDQ2	Physiology	N458Y affecting the encoded propeller and BTB/POZ domains	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001515	PF3D7_1343700 Q8IDQ2	Physiology	A481V affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001516	PF3D7_1343700 Q8IDQ2	Physiology	p.Tyr493His affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001517	PF3D7_1343700 Q8IDQ2	Physiology	N525D affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001518	PF3D7_1343700 Q8IDQ2	Physiology	N537I affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001519	PF3D7_1343700 Q8IDQ2	Physiology	p.Arg539Thr affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001520	PF3D7_1343700 Q8IDQ2	Physiology	p.Ile543Thr affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001521	PF3D7_1343700 Q8IDQ2	Physiology	p.Pro553Leu affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001522	PF3D7_1343700 Q8IDQ2	Physiology	R561H affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001523	PF3D7_1343700 Q8IDQ2	Physiology	V568G affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001524	PF3D7_1343700 Q8IDQ2	Physiology	P574L affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001525	PF3D7_1343700 Q8IDQ2	Physiology	p.Cys580Tyr affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001526	PF3D7_1343700 Q8IDQ2	Physiology	D584V affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001527	PF3D7_1343700 Q8IDQ2	Physiology	F673I affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001528	PF3D7_1343700 Q8IDQ2	Physiology	A675V affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001529	PF3D7_1343700 Q8IDQ2	Physiology	H719N affecting the encoded propeller domain	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
kelch 13 (K13)	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Candidate Gene	Straimer J; Gnädig NF; Witkowski B ; et al. (2015) Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clin[...]	GP00001388	PF13_0238 A0A077LQB4	Physiology	M476I	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		kelch 13 (K13)	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
Kit	Coloration (coat ; white-spotting)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Wong AK; Ruhe AL; Robertson KR ; et al. (2013) A de novo mutation in KIT causes white spotting in a subpopulation of German Shepherd dogs.	GP00002228	Kit P05532	Morphology	a 1-bp insertion of an adenine 70 bases downstream of the beginning of exon 2 resulting in frameshift N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Kit	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Brooks SA; Bailey E (2005) Exon skipping in the KIT gene causes a Sabino spotting pattern in horses.	GP00000515	Kit P05532	Morphology	T->A in intron 16; leads to skipping of exon 17	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP N	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00000516	Kit P05532	Morphology	c.2151C>G pY717* N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Indel	Felis catus domestic cat - (species) D	Domesticated	Association Mapping	Montague MJ; Li G; Gandolfi B ; et al. (2014) Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology[...]	GP00000518	Kit P05532	Morphology	Two nucleotide changes affecting site 3 of codon 345 and site 1 of codon 346 - resulting in Glu345Asp + His346Asn c. 1035_1036delinsCA GAGCAY > GACAAY	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		Kit (type III receptor protein-tyrosine kinase)	Felis catus domestic cat - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	2 Mutations:	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Linkage Mapping	Marklund S; Kijas J; Rodriguez-Martinez H ; et al. (1998) Molecular basis for the dominant white phenotype in the domestic pig. 3 Additional References Rubin CJ; Megens HJ; Martinez Barrio A (2012) Strong signatures of selection in the domestic pig genome. Sun G; Liang X; Qin K (2020) Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Us[...] Pielberg G; Day AE; Plastow GS (2003) A sensitive method for detecting variation in copy numbers of duplicated genes.	GP00000520	Kit P05532	Morphology	2 mutations	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D		Kit (type III receptor protein-tyrosine kinase)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (skin; coat)	Coding, SNP	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Leeb T (2015) Two variants in the KIT gene as candidate causative mutations for a dominant white and a white spott[...]	GP00001340	Kit P05532	Morphology	c.662A>C p.Tyr221Ser	Equus asinus ass - (species)	Equus asinus ass - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus asinus ass - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (skin; coat)	Coding, SNP	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Leeb T (2015) Two variants in the KIT gene as candidate causative mutations for a dominant white and a white spott[...]	GP00001341	Kit P05532	Morphology	c.1978+2T>A in splice donor site	Equus asinus ass - (species)	Equus asinus ass - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus asinus ass - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00001344	Kit P05532	Morphology	c.1789G>A p.G597R	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00002198	Kit P05532	Morphology	c.706A>T p.K236* N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00002199	Kit P05532	Morphology	c.1805C>T p.A602V	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Schlumbaum A ; et al. (2007) Allelic heterogeneity at the equine KIT locus in dominant white (W) horses.	GP00002200	Kit P05532	Morphology	c.1960G>A p.G654R	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002201	Kit P05532	Morphology	c.2222-1G>A (putative splicing site)	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002202	Kit P05532	Morphology	c.1126_1129delGAAC p.E376FfsX3 N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002203	Kit P05532	Morphology	c.2684+1G>A (putative splicing site)	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002204	Kit P05532	Morphology	c.338-1G>C (putative splicing site)	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002205	Kit P05532	Morphology	c.2193delG p.T732QfsX9 N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Brooks SA; Tozaki T ; et al. (2009) Seven novel KIT mutations in horses with white coat colour phenotypes.	GP00002206	Kit P05532	Morphology	c.856G>A p.G286R	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002207	Kit P05532	Morphology	c.1597T>C p.C533R	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002208	Kit P05532	Morphology	c.2021T>C p.L674P	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002209	Kit P05532	Morphology	c.2001A>T p.E667D	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002210	Kit P05532	Morphology	c.2472+5G>C (putative splicing mutation)	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002211	Kit P05532	Morphology	c.2489A>T p.K830I	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Rieder S; Tozaki T ; et al. (2011) Five novel KIT mutations in horses with white coat colour phenotypes.	GP00002212	Kit P05532	Morphology	c.2392_2445del p.H798_N815del N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Jude R; Haase B ; et al. (2013) Novel variants in the KIT and PAX3 genes in horses with white-spotted coat colour phenotypes.	GP00002213	Kit P05532	Morphology	c.2045G>A p.R682H	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Jude R; Haase B ; et al. (2013) Novel variants in the KIT and PAX3 genes in horses with white-spotted coat colour phenotypes.	GP00002214	Kit P05532	Morphology	c.1322A>G p.Y441C	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Jude R; Haase B ; et al. (2013) Novel variants in the KIT and PAX3 genes in horses with white-spotted coat colour phenotypes.	GP00002215	Kit P05532	Morphology	c.1346 + 1G>A (putative splicing mutation)	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Haase B; Jagannathan V; Rieder S ; et al. (2015) A novel KIT variant in an Icelandic horse with white-spotted coat colour.	GP00002216	Kit P05532	Morphology	c.2369delC p.Ala790Glufs*20 N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Dürig N; Jude R; Holl H ; et al. (2017) Whole genome sequencing reveals a novel deletion variant in the KIT gene in horses with white spotte[...]	GP00002219	Kit P05532	Morphology	g.77;740;239_77;742;136del1898insTATAT ~1.9-kb deletion N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hoban R; Castle K; Hamilton N ; et al. (2018) Novel KIT variants for dominant white in the Australian horse population.	GP00002220	Kit P05532	Morphology	c.1473T>G p.Cys491Trp	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hoban R; Castle K; Hamilton N ; et al. (2018) Novel KIT variants for dominant white in the Australian horse population.	GP00002221	Kit P05532	Morphology	c.2536delA p.Ser846Valfs*15	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hoban R; Castle K; Hamilton N ; et al. (2018) Novel KIT variants for dominant white in the Australian horse population.	GP00002222	Kit P05532	Morphology	c.668T>C p.Leu223Pro	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hug P; Jude R; Henkel J ; et al. (2019) A novel KIT deletion variant in a German Riding Pony with white-spotting coat colour phenotype.	GP00002223	Kit P05532	Morphology	g.79;579;925-79;581;197del 1273bp deletion N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Kit (type III receptor protein-tyrosine kinase)	Equus caballus horse - (species)	Published - Accepted by Curator
Kit (type III receptor protein-tyrosine kinase)	Coloration (coat ; white-spotting)	Coding, Deletion N	Camelus dromedarius Arabian camel - (species) D	Domesticated	Candidate Gene	Holl H; Isaza R; Mohamoud Y ; et al. (2017) A Frameshift Mutation in KIT is Associated with White Spotting in the Arabian Camel.	GP00002229	Kit P05532	Morphology	c.1842delG p.M614IfsX5 N	Camelus dromedarius Arabian camel - (species)	Camelus dromedarius Arabian camel - (species) D		Kit (type III receptor protein-tyrosine kinase)	Camelus dromedarius Arabian camel - (species)	Published - Accepted by Curator
Kit ligand	Coloration (coat)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Seitz JJ; Schmutz SM; Thue TD ; et al. (1999) A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and[...] 1 Additional References Aasland M; Klungland H; Lien S (2000) Two polymorphisms in the bovine mast cell growth factor gene (MGF).	GP00000101	KITLG P21583	Morphology	Ala193Asp ; missense mutation at position 654 - according to OMIA: c.572C>A p.A191N N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Kit ligand	Bos taurus cattle - (species)	Published - Accepted by Curator
KRT25	Hair type (curly)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Association Mapping	Morgenthaler C; Diribarne M; Capitan A ; et al. (2017) A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly[...] 1 Additional References Thomer A; Gottschalk M; Christmann A (2018) An epistatic effect of KRT25 on SP6 is involved in curly coat in horses.	GP00002230	Krt25 Q8VCW2	Morphology	c.266G>A p.Arg89His	Equus caballus horse - (species)	Equus caballus horse - (species) D		KRT25	Equus caballus horse - (species)	Published - Accepted by Curator
KRT25	Hair type (curly)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Association Mapping	Thomer A; Gottschalk M; Christmann A ; et al. (2018) An epistatic effect of KRT25 on SP6 is involved in curly coat in horses.	GP00002288	Sp6 Q9ESX2	Morphology	c.1090G>A p.Asp364Asn	Equus caballus horse - (species)	Equus caballus horse - (species) D		KRT25	Equus caballus horse - (species)	Published - Accepted by Curator
KRT27	Hair type (curly)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Association Mapping	Daetwyler HD; Capitan A; Pausch H ; et al. (2014) Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.	GP00002026	KRT27 Q0P5J6	Morphology	g.41636961C>G c.276C>G p.Asn92Lys	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		KRT27	Bos taurus cattle - (species)	Published - Accepted by Curator
KRT6A	Feathers	Coding, Deletion	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Ng CS; Wu P; Foley J ; et al. (2012) The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis.	GP00000527	Krt6a P50446	Morphology	69bp deletion partially overlapping with exon 5	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		KRT6A	Gallus gallus chicken - (species)	Published - Accepted by Curator
KRT71	Hair type (curly)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Cadieu E; Neff MW; Quignon P ; et al. (2009) Coat variation in the domestic dog is governed by variants in three genes.	GP00000524	Krt71 Q9R0H5	Morphology	c.451A>T in exon 2 - Arg151Trp	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		KRT71	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
KRT71	Hair type (curly and hairless)	2 Mutations: Coding	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Gandolfi B; Outerbridge CA; Beresford LG ; et al. (2010) The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.	GP00000525	Krt71 Q9R0H5	Morphology	2 mutations	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		KRT71	Felis catus domestic cat - (species)	Published - Accepted by Curator
KRT71	Hair type (curly and hairless)	Coding, Deletion N	Rattus norvegicus Norway rat - (species) D	Domesticated	Linkage Mapping	Kuramoto T; Hirano R; Kuwamura M ; et al. (2010) Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gen[...]	GP00001729	Krt71 Q9R0H5	Morphology	a 7-bp deletion at the splicing acceptor site of intron 1. The deletion provoked a 6-amino acid in-frame deletion (p.Val149_Gln154del) in the alpha-helical rod domain of KRT71 protein N	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D		KRT71	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
KRT71	Hair type (curly and hairless)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Association Mapping	Gandolfi B; Outerbridge CA; Beresford LG ; et al. (2010) The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.	GP00001730	Krt71 Q9R0H5	Morphology	eight base pair deletion mutation in exon one of the keratin 71 (KRT71) c.334delTGTGCCCA p.Met93AsnfsX14 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		KRT71	Bos taurus cattle - (species)	Published - Accepted by Curator
KRT71	Hair type (curly)	Coding, Indel	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Bauer A; Hadji Rasouliha S; Brunner MT ; et al. (2019) A second KRT71 allele in curly coated dogs. 1 Additional References Salmela E; Niskanen J; Arumilli M (2019) A novel KRT71 variant in curly-coated dogs.	GP00002231	Krt71 Q9R0H5	Morphology	c.1266_1273delinsACA p.Ser422ArgfsTer?	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		KRT71	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
KRT71	Hair type (curly)	Coding, SNP N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Gandolfi B; Alhaddad H; Joslin SE ; et al. (2013) A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats.	GP00002232	Krt71 Q9R0H5	Morphology	c.445-1G>C in splice site likely disrupts the highly conserved acceptor splicing site of intron one. Sequence of the complete RNA transcript revealed that an alternative downstream acceptor was employed N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		KRT71	Felis catus domestic cat - (species)	Published - Accepted by Curator
KRT75L4	Feathers	Coding, Deletion	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Guo X; Li YQ; Wang MS ; et al. (2018) A parallel mechanism underlying frizzle in domestic chickens.	GP00002334	KRT75L4 A0A1L1RKR4	Morphology	15bp deletion resulting in loss of 5 conserved amino-acids	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		KRT75L4	Gallus gallus chicken - (species)	Published - Accepted by Curator
KUK	Root development	2 Mutations: Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Meijón M; Satbhai SB; Tsuchimatsu T ; et al. (2014) Genome-wide association study using cellular traits identifies a new regulator of root development i[...]	GP00001233	At1g60370 O80758	Morphology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		KUK	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
L6	Pathogen resistance	Coding, Insertion N	Linum usitatissimum flax - (species)	Intraspecific	Linkage Mapping	Lawrence GJ; Finnegan EJ; Ayliffe MA ; et al. (1995) The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 an[...]	GP00000528	L6 Q40253	Physiology	Truncated protein due to insertion of a transposable element. Reversion to resistance among descendants of mutant X75 was associated with excision of the newly transposable element Ac. N	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species)		L6	Linum usitatissimum flax - (species)	Published - Accepted by Curator
lbh (limb bud and heart homolog)	Cranio-facial morphology (mandible)	Coding, SNP	Labeotropheus fuelleborni blue mbuna - (species) D	Interspecific	Linkage Mapping	Powder KE; Cousin H; McLinden GP ; et al. (2014) A nonsynonymous mutation in the transcriptional regulator lbh is associated with cichlid craniofacia[...]	GP00001387	LBH Q53QV2	Morphology	G>A p.R17Q	Maylandia zebra zebra mbuna - (species)	Labeotropheus fuelleborni blue mbuna - (species) D		lbh (limb bud and heart homolog)	Labeotropheus fuelleborni blue mbuna - (species)	Published - Accepted by Curator
Ldia2 - Diaphanous-related formin	Shell chirality (coiling)	Coding, Deletion N	Lymnaea stagnalis great pond snail - (species) D	Intraspecific	Association Mapping	Davison A; McDowell GS; Holden JM ; et al. (2016) Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.	GP00000538	DIAPH1 O60610	Morphology	1bp deletion resulting in frame-shift (pseudogenization) N	Lymnaea stagnalis great pond snail - (species)	Lymnaea stagnalis great pond snail - (species) D		Ldia2 - Diaphanous-related formin	Lymnaea stagnalis great pond snail - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002656	lectin-24A Q9VQU4	Physiology	a 165bp deletion in the protein coding sequence that results in a shift in the reading frame and a premature stop codon (p.Phe217_Glu273del*) N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, SNP N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002657		Physiology	L81 >STOP - point mutation that introduces a premature stop codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, SNP N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002658	lectin-24A Q9VQU4	Physiology	Q254 >STOP - point mutation that introduces a premature stop codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lectin-24A	Pathogen resistance (parasitic wasp)	Coding, SNP N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022 ) Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite	GP00002659	lectin-24A Q9VQU4	Physiology	F217 >STOP - point mutation that introduces a premature stop codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Lectin-24A	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Lethal Hybrid rescue	Hybrid incompatibility (F1 male lethality)	Coding, Insertion	Drosophila simulans (species) D	Interspecific	Linkage Mapping	Brideau NJ; Flores HA; Wang J ; et al. (2006) Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. 2 Additional References Nolte V; Weigel D; Schlötterer C (2008) The impact of shared ancestral variation on hybrid male lethality--a 16 codon indel in the Drosophil[...] Maheshwari S; Barbash DA (2012) An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]	GP00000540	Lhr Q95RV3	Physiology	16a.a. insertion with effect in sensitive background only (Maheshwari and Barbash 2012)	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species) D		Lethal Hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator
Lethal Hybrid rescue	Hybrid incompatibility (F1 male lethality)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Maheshwari S; Barbash DA (2012) An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]	GP00000541	Lhr Q95RV3	Physiology	Coding divergence in a conserved stretch of 10 C-terminal amino-acids	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Lethal Hybrid rescue	Drosophila simulans (species)	Published - Accepted by Curator
LIMONENE-MYRCENE SYNTHASE (LMS)	Fragrance (floral terpenoid volatiles; D -limonene and beta-myrcene)	Coding, SNP N	Erythranthe cardinalis (species) D	Interspecific	Linkage Mapping	Byers KJ; Vela JP; Peng F ; et al. (2014) Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...]	GP00001761	LMS W6A2K5	Physiology	G66T transversion mutation in exon 3 of McLMS (KM659024) that results in a nonsense mutation in the McLMS protein (G201X) N	Erythranthe lewisii (species)	Erythranthe cardinalis (species) D		LIMONENE-MYRCENE SYNTHASE (LMS)	Erythranthe cardinalis (species)	Published - Accepted by Curator
LIPH	Hair length	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Linkage Mapping	Diribarne M; Mata X; Chantry-Darmon C ; et al. (2011) A deletion in exon 9 of the LIPH gene is responsible for the rex hair coat phenotype in rabbits (Ory[...]	GP00000550	Liph Q8CIV3	Morphology	1bp deletion resulting in frameshift N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		LIPH	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
Low-density lipoprotein receptor-related protein 2	Organ size (eye; enlarged)	3 Mutations: Coding N	Carassius auratus goldfish - (species) D	Domesticated	Association Mapping	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002349	LRP2 P98164	Morphology	3 mutations	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D		Low-density lipoprotein receptor-related protein 2	Carassius auratus goldfish - (species)	Published - Accepted by Curator
Lr21	Pathogen resistance	Coding, Complex Change	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Huang L; Brooks S; Li W ; et al. (2009) Evolution of new disease specificity at a simple resistance locus in a crop-weed complex: reconstitu[...]	GP00000551	C5ID17	Physiology	Novel pathogen specificity resulting from chimerism of the parental alleles after intragenic recombination	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Lr21	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
Lr67	Pathogen resistance (rust ; mildew)	Coding, SNP	Triticum aestivum bread wheat - (species) D	Domesticated	Linkage Mapping	Moore JW; Herrera-Foessel S; Lan C ; et al. (2015) A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat.	GP00001535	A0A0S1LH45	Physiology	Gly144Arg (exon 2) leads to a protein incapable of glucose import; LR67res exerts a dominant-negative effect through heterodimerization with these functional transporters to reduce glucose uptake.; alterations in hexose transport in infected leaves may explain its ability to reduce the growth of multiple biotrophic pathogen species	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species) D		Lr67	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intergeneric or Higher	Candidate Gene	Wood KV; Lam YA; Seliger HH ; et al. (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors.	GP00000552	P08659	Physiology	several nucleotide substitutions leading to several amino acid changes -exact amino acid changes unknown	Photinus pyralis common eastern firefly - (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000553	P08659	Physiology	T739G and C740G in exon 4; leading to one amino acid change - colour difference between the yellow- and orange-emitting luciferases is due entirely to S247G	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	2 Mutations: Coding SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00000554	P08659	Physiology	2 mutations	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
luciferase	Bioluminescence spectrum	Coding, SNP	Pyrophorus plagiophthalamus (species)	Intraspecific	Candidate Gene	Stolz U; Velez S; Wood KV ; et al. (2003) Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle. 2 Additional References Wood KV; Lam YA; Seliger HH (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Wood KV (1990 Apr-Jun) Luc genes: introduction of colour into bioluminescence assays.	GP00001758	P08659	Physiology	exact causing amino acid change(s) unknown	Pyrophorus plagiophthalamus (species)	Pyrophorus plagiophthalamus (species)		luciferase	Pyrophorus plagiophthalamus (species)	Published - Accepted by Curator
Lysine histidine transporter 1	Pathogen resistance	Coding, Insertion N	Zea mays (species) D	Domesticated	Linkage Mapping	Zhao Y; Lu X; Liu C ; et al. (2012) Identification and fine mapping of rhm1 locus for resistance to Southern corn leaf blight in maize.	GP00000555	LHT1 Q9FKS8	Physiology	354bp insertioin resulting in premature stop codon N	Zea mays (species)	Zea mays (species) D		Lysine histidine transporter 1	Zea mays (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Opisthocomus hoazin (species) D	Intergeneric or Higher	Candidate Gene	Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.	GP00000556	LYZ1 P04421	Physiology	5 mutations	Aves birds - (class)	Opisthocomus hoazin (species) D		lysozyme	Opisthocomus hoazin (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Bos taurus cattle - (species)	Intergeneric or Higher	Candidate Gene	Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2) Adaptive evolution in the stomach lysozymes of foregut fermenters. 1 Additional References Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.	GP00000557	LYZ1 P04421	Physiology	5 mutations	Mammalia mammals - (class)	Bos taurus cattle - (species)		lysozyme	Bos taurus cattle - (species)	Published - Accepted by Curator
lysozyme	Digestion (anaerobic enzymatic activity)	5 Mutations: Coding SNP	Colobinae (subfamily)	Intergeneric or Higher	Candidate Gene	Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2) Adaptive evolution in the stomach lysozymes of foregut fermenters. 3 Additional References Kornegay JR; Schilling JW; Wilson AC (1994) Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin. Swanson KW; Irwin DM; Wilson AC (1991) Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection. Messier W; Stewart CB (1997) Episodic adaptive evolution of primate lysozymes.	GP00000558	LYZ1 P04421	Physiology	5 mutations	Primates (order)	Colobinae (subfamily)		lysozyme	Colobinae (subfamily)	Published - Accepted by Curator
M	Pathogen resistance	Coding, Deletion	Linum usitatissimum flax - (species) D	Intraspecific	Linkage Mapping	Anderson PA; Lawrence GJ; Morrish BC ; et al. (1997) Inactivation of the flax rust resistance gene M associated with loss of a repeated unit within the l[...]	GP00000559	P93244	Physiology	426bp deletion, probably by unequal recombination	Linum usitatissimum flax - (species)	Linum usitatissimum flax - (species) D		M	Linum usitatissimum flax - (species)	Published - Accepted by Curator
mab-23	Male genitalia	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Lints R; Emmons SW (2002) Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the [...] 1 Additional References Hodgkin J; Doniach T (1997) Natural variation and copulatory plug formation in Caenorhabditis elegans.	GP00001323	mab-23 G5ECK3	Morphology	TGC>TTC - cysteine of the DM motif transformed into phenylalanine; so is likely to disrupt DNA-binding function N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		mab-23	Caenorhabditis elegans (species)	Published - Accepted by Curator
MAM1	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kroymann J; Textor S; Tokuhisa JG ; et al. (2001) A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chai[...] 3 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...] Züst T; Heichinger C; Grossniklaus U (2012) Natural enemies drive geographic variation in plant defenses.	GP00000562	MAM1 Q9FG67	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		MAM1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MAM3	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001303	PMA1 P05030	Physiology	C>G (Gly > Arg) @ position 250	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MAM3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MAM3	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001304	PMA1 P05030	Physiology	C>T (Val > Ile) @ position 1120	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MAM3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MAM3	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001305	PMA1 P05030	Physiology	C>T (Ser > Asn) @ position 806	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MAM3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000567	MC1R Q01726	Morphology	2bp deletion resulting in frameshift N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (albinism)	Coding, SNP	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Gross JB; Borowsky R; Tabin CJ (2009) A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]	GP00000568	MC1R Q01726	Morphology	Arg164Cys (position 160 in human; so this mutation resembles the human R160W hypomorphic human mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		MC1R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	2 Mutations: Coding SNP	Vulpes lagopus Arctic fox - (species)	Interspecific	Candidate Gene	Våge DI; Fuglei E; Snipstad K ; et al. (2005) Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) [...] 1 Additional References Liu Z; Gong Y; Feng M (2016) Genetic variations of the coding region of the melanocortin receptor 1 (MC1R) gene in the fox.	GP00000569	MC1R Q01726	Morphology	2 mutations	Vulpes vulpes red fox - (species)	Vulpes lagopus Arctic fox - (species)		MC1R	Vulpes lagopus Arctic fox - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Klungland H; Våge DI; Gomez-Raya L ; et al. (1995) The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. 1 Additional References Joerg H; Fries HR; Meijerink E (1996) Red coat color in Holstein cattle is associated with a deletion in the MSHR gene.	GP00000571	MC1R Q01726	Morphology	1 bp deletion at 104: frameshift and premature stop at amino acid 156 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		MC1R	Bos taurus cattle - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Klungland H; Våge DI; Gomez-Raya L ; et al. (1995) The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination.	GP00000572	MC1R Q01726	Morphology	L99P ; presumably constitutively active - g.14757910T>C c.296T>C p.L99P	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		MC1R	Bos taurus cattle - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Newton JM; Wilkie AL; He L ; et al. (2000) Melanocortin 1 receptor variation in the domestic dog. 1 Additional References Everts RE; Rothuizen J; van Oost BA (2000) Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) [...]	GP00000573	MC1R Q01726	Morphology	R306ter; deletes 12 of 17 a.a. from C-terminus	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Ellinwood NM ; et al. (2003 Jan-Feb) MC1R studies in dogs with melanistic mask or brindle patterns.	GP00000574	MC1R Q01726	Morphology	M264V	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000576	MC1R Q01726	Morphology	R18C	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000577	MC1R Q01726	Morphology	R109W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000578	MC1R Q01726	Morphology	R160W	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Chaetodipus intermedius rock pocket mouse - (species) D	Intraspecific	Candidate Gene	Nachman MW; Hoekstra HE; D'Agostino SL (2003) The genetic basis of adaptive melanism in pocket mice.	GP00000579	MC1R Q01726	Morphology	Q233H	Chaetodipus intermedius rock pocket mouse - (species)	Chaetodipus intermedius rock pocket mouse - (species) D		MC1R	Chaetodipus intermedius rock pocket mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Candidate Gene	Marklund L; Moller MJ; Sandberg K ; et al. (1996) A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated wit[...] 1 Additional References Pruvost M; Bellone R; Benecke N (2011) Genotypes of predomestic horses match phenotypes painted in Paleolithic works of cave art.	GP00000580	MC1R Q01726	Morphology	S83F	Equus caballus horse - (species)	Equus caballus horse - (species)		MC1R	Equus caballus horse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Puma yagouaroundi jaguarundi - (species) D	Intraspecific	Candidate Gene	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000581	MC1R Q01726	Morphology	Deletion of aa 95-102	Puma yagouaroundi jaguarundi - (species)	Puma yagouaroundi jaguarundi - (species) D		MC1R	Puma yagouaroundi jaguarundi - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000582	MC1R Q01726	Morphology	1bp deletion at 183; frameshift & premature stop N	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus poschiavinus (species)	Interspecific	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000583	MC1R Q01726	Morphology	S69L	Mus musculus house mouse - (species)	Mus poschiavinus (species)		MC1R	Mus poschiavinus (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000584	MC1R Q01726	Morphology	E92K	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Candidate Gene	Robbins LS; Nadeau JH; Johnson KR ; et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MS[...]	GP00000585	MC1R Q01726	Morphology	L98P	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Wada A; Kunieda T; Nishimura M ; et al. (2005 Mar-Apr) A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred s[...]	GP00000586	MC1R Q01726	Morphology	W252C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		MC1R	Mus musculus house mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, Deletion	Numida meleagris helmeted guineafowl - (species) D	Domesticated	Candidate Gene	Vidal O; Araguas RM; Fernández E ; et al. (2010) Melanism in guinea fowl (Numida meleagris) is associated with a deletion of Phenylalanine-256 in the[...]	GP00000587	MC1R Q01726	Morphology	Phe256del	Numida meleagris helmeted guineafowl - (species)	Numida meleagris helmeted guineafowl - (species) D		MC1R	Numida meleagris helmeted guineafowl - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Fontanesi L; Tazzoli M; Beretti F ; et al. (2006) Mutations in the melanocortin 1 receptor (MC1R) gene are associated with coat colours in the domesti[...]	GP00000588	MC1R Q01726	Morphology	6bp in-frame del of 94-95	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		MC1R	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Fontanesi L; Tazzoli M; Beretti F ; et al. (2006) Mutations in the melanocortin 1 receptor (MC1R) gene are associated with coat colours in the domesti[...]	GP00000589	MC1R Q01726	Morphology	30bp in-frame del of 102-111	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		MC1R	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Fontanesi L; Scotti E; Colombo M ; et al. (2010) A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with t[...]	GP00000590	MC1R Q01726	Morphology	6bp in frame deletion c.[124G>A;125_130del6] + L44T (homozygous state in Japanese, Rhinelander and Dutch tricolour rabbits )	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		MC1R	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Candidate Gene	Våge DI; Klungland H; Lu D ; et al. (1999) Molecular and pharmacological characterization of dominant black coat color in sheep. 1 Additional References Hepp D; Gonçalves GL; Moreira GR (2016) Epistatic Interaction of the Melanocortin 1 Receptor and Agouti Signaling Protein Genes Modulates Wo[...]	GP00000591	MC1R Q01726	Morphology	D121N	Ovis aries sheep - (species)	Ovis aries sheep - (species)		MC1R	Ovis aries sheep - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species)	Domesticated	Candidate Gene	Våge DI; Klungland H; Lu D ; et al. (1999) Molecular and pharmacological characterization of dominant black coat color in sheep. 1 Additional References Hepp D; Gonçalves GL; Moreira GR (2016) Epistatic Interaction of the Melanocortin 1 Receptor and Agouti Signaling Protein Genes Modulates Wo[...]	GP00000592	MC1R Q01726	Morphology	M73K	Ovis aries sheep - (species)	Ovis aries sheep - (species)		MC1R	Ovis aries sheep - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Panthera onca jaguar - (species) D	Intraspecific	Candidate Gene	Eizirik E; Yuhki N; Johnson WE ; et al. (2003) Molecular genetics and evolution of melanism in the cat family.	GP00000593	MC1R Q01726	Morphology	Deletion of aa 101-105 and L106T	Panthera onca jaguar - (species)	Panthera onca jaguar - (species) D		MC1R	Panthera onca jaguar - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Peromyscus polionotus oldfield mouse - (species)	Intraspecific	Linkage Mapping	Hoekstra HE; Hirschmann RJ; Bundey RA ; et al. (2006) A single amino acid mutation contributes to adaptive beach mouse color pattern.	GP00000594	MC1R Q01726	Morphology	R65C	Peromyscus polionotus oldfield mouse - (species)	Peromyscus polionotus oldfield mouse - (species)		MC1R	Peromyscus polionotus oldfield mouse - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Rattus rattus black rat - (species)	Interspecific	Candidate Gene	Kambe Y; Tanikawa T; Matsumoto Y ; et al. (2011) Origin of agouti-melanistic polymorphism in Wild Black Rats (Rattus rattus) inferred from Mc1r gene [...]	GP00000595	MC1R Q01726	Morphology	Glu93Lys	Rattus tanezumi Oriental house rat - (species)	Rattus rattus black rat - (species)		MC1R	Rattus rattus black rat - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Sciurus carolinensis gray squirrel - (species) D Sciurus niger fox squirrel - (species) D	Intraspecific	Candidate Gene	McRobie H; Thomas A; Kelly J (2009 Nov-Dec) The genetic basis of melanism in the gray squirrel (Sciurus carolinensis). 1 Additional References McRobie HR; Moncrief ND; Mundy NI (2019) Multiple origins of melanism in two species of North American tree squirrel (Sciurus).	GP00000596	MC1R Q01726	Morphology	Deletion of 8 a.a.	Sciurus carolinensis gray squirrel - (species) Sciurus niger fox squirrel - (species)	Sciurus carolinensis gray squirrel - (species) D Sciurus niger fox squirrel - (species) D		MC1R	Sciurus carolinensis gray squirrel - (species) Sciurus niger fox squirrel - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Ursus americanus American black bear - (species)	Intraspecific	Candidate Gene	Ritland K; Newton C; Marshall HD (2001) Inheritance and population structure of the white-phased "Kermode" black bear.	GP00000597	MC1R Q01726	Morphology	Y298C	Ursus americanus American black bear - (species)	Ursus americanus American black bear - (species)		MC1R	Ursus americanus American black bear - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Vulpes vulpes red fox - (species)	Domesticated	Candidate Gene	Våge DI; Lu D; Klungland H ; et al. (1997) A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes. 1 Additional References Liu Z; Gong Y; Feng M (2016) Genetic variations of the coding region of the melanocortin receptor 1 (MC1R) gene in the fox.	GP00000598	MC1R Q01726	Morphology	C125R; constitutively active receptor	Vulpes vulpes red fox - (species)	Vulpes vulpes red fox - (species)		MC1R	Vulpes vulpes red fox - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Anser caerulescens snow goose - (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000599	MC1R Q01726	Morphology	V85M	Anser caerulescens snow goose - (species)	Anser caerulescens snow goose - (species)		MC1R	Anser caerulescens snow goose - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Coereba flaveola Bananaquit - (species) D	Intraspecific	Candidate Gene	Theron E; Hawkins K; Bermingham E ; et al. (2001) The molecular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor point mu[...]	GP00000600	MC1R Q01726	Morphology	E92K	Coereba flaveola Bananaquit - (species)	Coereba flaveola Bananaquit - (species) D		MC1R	Coereba flaveola Bananaquit - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Columba livia rock pigeon - (species)	Domesticated	Candidate Gene	Guernsey MW; Ritscher L; Miller MA ; et al. (2013) A Val85Met mutation in melanocortin-1 receptor is associated with reductions in eumelanic pigmentati[...]	GP00000601	MC1R Q01726	Morphology	Val85Met (G253A)	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species)		MC1R	Columba livia rock pigeon - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Nadeau NJ; Minvielle F; Mundy NI (2006) Association of a Glu92Lys substitution in MC1R with extended brown in Japanese quail (Coturnix japon[...]	GP00000602	MC1R Q01726	Morphology	E92K	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)		MC1R	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, Deletion	Falco eleonorae (species) D	Intraspecific	Candidate Gene	Gangoso L; Grande JM; Ducrest AL ; et al. (2011) MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the E[...]	GP00000603	MC1R Q01726	Morphology	Deletion of 3 a.a.	Falco eleonorae (species)	Falco eleonorae (species) D		MC1R	Falco eleonorae (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Falco rusticolus gyrfalcon - (species)	Intraspecific	Candidate Gene	Johnson JA; Ambers AD; Burnham KK (2012 May-Jun) Genetics of plumage color in the Gyrfalcon (Falco rusticolus): analysis of the melanocortin-1 recept[...]	GP00000604	MC1R Q01726	Morphology	Val128Ile	Falco rusticolus gyrfalcon - (species)	Falco rusticolus gyrfalcon - (species)		MC1R	Falco rusticolus gyrfalcon - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers; eyes)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...] 2 Additional References Kerje S; Lind J; Schütz K (2003) Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken. Dávila SG; Gil MG; Resino-Talaván P (2014) Association between polymorphism in the melanocortin 1 receptor gene and E locus plumage color pheno[...]	GP00000605	MC1R Q01726	Morphology	E92K; constitutive activation	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...]	GP00000606	MC1R Q01726	Morphology	C33W	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...]	GP00000607	MC1R Q01726	Morphology	D37G	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Takeuchi S; Suzuki H; Yabuuchi M ; et al. (1996) A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the ch[...]	GP00000608	MC1R Q01726	Morphology	L244P	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Kerje S; Lind J; Schütz K ; et al. (2003) Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken. 1 Additional References Dávila SG; Gil MG; Resino-Talaván P (2014) Association between polymorphism in the melanocortin 1 receptor gene and E locus plumage color pheno[...]	GP00000609	MC1R Q01726	Morphology	H215P	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Malurus leucopterus white-winged fairy-wren - (species)	Intraspecific	Candidate Gene	Doucet SM; Shawkey MD; Rathburn MK ; et al. (2004) Concordant evolution of plumage colour, feather microstructure and a melanocortin receptor gene betw[...]	GP00000610	MC1R Q01726	Morphology	A16T caused by guanine-to-adenine (G_A) transition at site 46; and/or I38N cause by a tyrosine-to-adenine (T_A) transition at site 113; and/or V11N caused by a G_A transition at site 331; and/or Q157R caused by an A_G substitution at site 470; Val166Ileu - exact causing amino acid change(s) unknown	Malurus leucopterus white-winged fairy-wren - (species)	Malurus leucopterus white-winged fairy-wren - (species)		MC1R	Malurus leucopterus white-winged fairy-wren - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Stercorarius parasiticus (species)	Intraspecific	Candidate Gene	Mundy NI; Badcock NS; Hart T ; et al. (2004) Conserved genetic basis of a quantitative plumage trait involved in mate choice.	GP00000611	MC1R Q01726	Morphology	R230H	Stercorarius parasiticus (species)	Stercorarius parasiticus (species)		MC1R	Stercorarius parasiticus (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula leucogaster (species)	Intraspecific	Candidate Gene	Baião PC; Parker PG (2012 May-Jun) Evolution of the melanocortin-1 receptor (MC1R) in Boobies and Gannets (Aves, Suliformes).	GP00000612	MC1R Q01726	Morphology	R112H	Sula leucogaster (species)	Sula leucogaster (species)		MC1R	Sula leucogaster (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Sula sula red-footed booby - (species)	Intraspecific	Candidate Gene	Baião PC; Schreiber E; Parker PG (2007 Jul-Aug) The genetic basis of the plumage polymorphism in red-footed boobies (Sula sula): a melanocortin-1 re[...]	GP00000613	MC1R Q01726	Morphology	V85M and/or H207R; current data cannot determine which one or if both these substitutions are underlying the phenotypic variation	Sula sula red-footed booby - (species)	Sula sula red-footed booby - (species)		MC1R	Sula sula red-footed booby - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Smith R; Healy E; Siddiqui S (1998) Melanocortin 1 receptor variants in an Irish population.	GP00000615	MC1R Q01726	Morphology	R151C	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000616	MC1R Q01726	Morphology	D294H	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Smith R; Healy E; Siddiqui S ; et al. (1998) Melanocortin 1 receptor variants in an Irish population. 1 Additional References Box NF; Wyeth JR; O'Gorman LE (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.	GP00000617	MC1R Q01726	Morphology	R160W	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Box NF; Wyeth JR; O'Gorman LE ; et al. (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. 3 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. Harding RM; Healy E; Ray AJ (2000) Evidence for variable selective pressures at MC1R. Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000618	MC1R Q01726	Morphology	Val60Leu	Homo sapiens human - (species)	Homo sapiens human - (species) D		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000619	MC1R Q01726	Morphology	Asp84Glu	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000620	MC1R Q01726	Morphology	Val92Met	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000621	MC1R Q01726	Morphology	Arg142His	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000622	MC1R Q01726	Morphology	Arg151Cys	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000623	MC1R Q01726	Morphology	Ile155Thr	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000624	MC1R Q01726	Morphology	Arg160Trp	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000625	MC1R Q01726	Morphology	Arg163Gln	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (red hair)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 1 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...]	GP00000626	MC1R Q01726	Morphology	Asp294His	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Aspidoscelis inornatus Little striped whiptail - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000627	MC1R Q01726	Morphology	I170T	Aspidoscelis inornatus Little striped whiptail - (species)	Aspidoscelis inornatus Little striped whiptail - (species)		MC1R	Aspidoscelis inornatus Little striped whiptail - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Holbrookia maculata lesser earless lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Hoekstra HE; Nachman MW (2004) Adaptive reptile color variation and the evolution of the Mc1r gene. 1 Additional References Rosenblum EB; Römpler H; Schöneberg T (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000628	MC1R Q01726	Morphology	V168I; but failed functional validation in Rosenblum et al. 2010	Holbrookia maculata lesser earless lizard - (species)	Holbrookia maculata lesser earless lizard - (species)		MC1R	Holbrookia maculata lesser earless lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (scales)	Coding, SNP	Sceloporus undulatus fence lizard - (species)	Intraspecific	Candidate Gene	Rosenblum EB; Römpler H; Schöneberg T ; et al. (2010) Molecular and functional basis of phenotypic convergence in white lizards at White Sands.	GP00000629	MC1R Q01726	Morphology	H208Y	Sceloporus undulatus fence lizard - (species)	Sceloporus undulatus fence lizard - (species)		MC1R	Sceloporus undulatus fence lizard - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Lalueza-Fox C; Römpler H; Caramelli D ; et al. (2007) A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals.	GP00000630	MC1R Q01726	Morphology	Arg307Gly	Homo sapiens human - (species)	Homo sapiens human - (species)		MC1R	Homo sapiens human - (species)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, Insertion N	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Linkage Mapping	Kijas JM; Moller M; Plastow G ; et al. (2001) A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pig[...] 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000631	MC1R Q01726	Morphology	2bp insertion at 23 generates early stop @ 56 & D"121"N ? N	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000632	MC1R Q01726	Morphology	V"92"M actually at 95	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000633	MC1R Q01726	Morphology	D"121"N Actually 124	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000634	MC1R Q01726	Morphology	A"161"V actually 164	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000635	MC1R Q01726	Morphology	L"99" P Actually 102	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (skin)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Candidate Gene	Kijas JM; Wales R; Törnsten A ; et al. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00000636	MC1R Q01726	Morphology	A"240"T actually 243	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Gustafson NA; Gandolfi B; Lyons LA (2017) Not another type of potato: MC1R and the russet coloration of Burmese cats.	GP00001330	MC1R Q01726	Morphology	3bp deletion at c.439-441del (p.Phe146del)	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		MC1R	Felis catus domestic cat - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Monarcha castaneiventris Makira monarch - (species) D	Intraspecific	Association Mapping	Uy JA; Cooper EA; Cutie S ; et al. (2016) Mutations in different pigmentation genes are associated with parallel melanism in island flycatcher[...]	GP00001333	MC1R Q01726	Morphology	Asp119Asn	Monarcha castaneiventris Makira monarch - (species)	Monarcha castaneiventris Makira monarch - (species) D		MC1R	Monarcha castaneiventris Makira monarch - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Candidate Gene	Rubin CJ; Megens HJ; Martinez Barrio A ; et al. (2012) Strong signatures of selection in the domestic pig genome. 1 Additional References Liu R; Jin L; Long K (2016) Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC[...]	GP00001337	MC1R Q01726	Morphology	c.G>A p.Asp124Asn	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D		MC1R	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Arctocephalus gazella antarctic fur seal - (species) D	Intraspecific	Candidate Gene	Norris BJ; Whan VA (2008) A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sh[...]	GP00001338	MC1R Q01726	Morphology	c.C>T p.Ser291Phe	Arctocephalus gazella antarctic fur seal - (species)	Arctocephalus gazella antarctic fur seal - (species) D		MC1R	Arctocephalus gazella antarctic fur seal - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Tyto alba Barn owl - (species) D	Intraspecific	Candidate Gene	San-Jose LM; Ducrest AL; Ducret V ; et al. (2015) Effect of the MC1R gene on sexual dimorphism in melanin-based colorations. 3 Additional References San-Jose LM; Ducret V; Ducrest AL (2017) Beyond mean allelic effects: A locus at the major color gene MC1R associates also with differing lev[...] Burri R; Antoniazza S; Gaigher A (2016) The genetic basis of color-related local adaptation in a ring-like colonization around the Mediterra[...] San-Jose LM; Ducrest AL; Ducret V (2017) MC1R variants affect the expression of melanocortin and melanogenic genes and the association betwee[...]	GP00001339	MC1R Q01726	Morphology	p.Val126Ile	Tyto alba Barn owl - (species)	Tyto alba Barn owl - (species) D	R	MC1R	Tyto alba Barn owl - (species)	Reviewed		September 26, 2019 17:00
MC1R	Coloration (coat)	2 Mutations: Coding SNP	Rangifer tarandus reindeer - (species) D	Domesticated	Candidate Gene	Våge DI; Nieminen M; Anderson DG ; et al. (2014) Two missense mutations in melanocortin 1 receptor (MC1R) are strongly associated with dark ventral c[...]	GP00001350	Mc1r Q01727	Morphology	2 mutations	Rangifer tarandus reindeer - (species)	Rangifer tarandus reindeer - (species) D		MC1R	Rangifer tarandus reindeer - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Equus asinus ass - (species) D	Domesticated	Candidate Gene	Abitbol M; Legrand R; Tiret L (2014) A missense mutation in melanocortin 1 receptor is associated with the red coat colour in donkeys.	GP00001351	Mc1r Q01727	Morphology	c.629T>C p.Met210Thr	Equus asinus ass - (species)	Equus asinus ass - (species) D		MC1R	Equus asinus ass - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Anas platyrhynchos mallard - (species) D	Domesticated	Candidate Gene	Yu W; Wang C; Xin Q ; et al. (2013) Non-synonymous SNPs in MC1R gene are associated with the extended black variant in domestic ducks (A[...]	GP00001352	Mc1r Q01727	Morphology	c.52G>A p.Glu18Lys	Anas platyrhynchos mallard - (species)	Anas platyrhynchos mallard - (species) D		MC1R	Anas platyrhynchos mallard - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Capra hircus goat - (species) D	Domesticated	Candidate Gene	Fontanesi L; Beretti F; Riggio V ; et al. (2009) Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: ass[...]	GP00001353	Mc1r Q01727	Morphology	c.801C>G p.Cys267Trp	Capra hircus goat - (species)	Capra hircus goat - (species) D		MC1R	Capra hircus goat - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP N	Bos grunniens domestic yak - (species) D	Domesticated	Candidate Gene	Zhang MQ; Xu X; Luo SJ (2014) The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens).	GP00001354	Mc1r Q01727	Morphology	p.Gln34* and p.Met73Leu and p.Arg142Pro - p.Met73Leu and p.Arg142Pro were only found in heterozygous and their association with phenotype is supposed but not sure N	Bos grunniens domestic yak - (species)	Bos grunniens domestic yak - (species) D		MC1R	Bos grunniens domestic yak - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Stercorarius parasiticus (species)	Intraspecific	Candidate Gene	Janssen K; Mundy NI (2013) Molecular population genetics of the melanic plumage polymorphism in Arctic skuas (Stercorarius para[...]	GP00001355	Mc1r Q01727	Morphology	Melanic and nonmelanic haplotypes in the Arctic skua are defined by three amino acid changes: nonmelanic: His8-Glu12-Arg230; melanic: Arg8-Lys12-His230. The effect of each single amino acid change has not been tested	Stercorarius parasiticus (species)	Stercorarius parasiticus (species)		MC1R	Stercorarius parasiticus (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	3 Mutations: Coding SNP	Ramphastos dicolorus (species) D Ramphastos vitellinus (species) D Ramphastos tucanus (species) D Ramphastos toco (species) D	Interspecific	Candidate Gene	Corso J; Mundy NI; Fagundes NJ ; et al. (2016) Evolution of dark colour in toucans (Ramphastidae): a case of molecular adaptation?	GP00001367	Mc1r Q01727	Morphology	3 mutations	Ramphastidae (family)	Ramphastos dicolorus (species) D Ramphastos vitellinus (species) D Ramphastos tucanus (species) D Ramphastos toco (species) D		MC1R	Ramphastos dicolorus (species) Ramphastos vitellinus (species) Ramphastos tucanus (species) Ramphastos toco (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Calidris pugnax ruff - (species) D	Intraspecific	Association Mapping	Lamichhaney S; Fan G; Widemo F ; et al. (2016) Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pug[...] 1 Additional References Küpper C; Stocks M; Risse JE (2016) A supergene determines highly divergent male reproductive morphs in the ruff.	GP00001466	MC1R Q01726	Morphology	Several amino acid changes. The His207Arg substitution most likely has functional consequences because the same variant is associated with light color in the red-footed booby.	Calidris pugnax ruff - (species)	Calidris pugnax ruff - (species) D		MC1R	Calidris pugnax ruff - (species)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP	Leopardus geoffroyi Geoffroy's cat - (species) D	Intraspecific	Candidate Gene	Schneider A; Henegar C; Day K ; et al. (2015) Recurrent evolution of melanism in South American felids.	GP00001733	MC1R Q01726	Morphology	All melanistic individuals were heterozygous for four variants that predicted three nonsynonymous substitutions, p.C125R, p.T177I, and p.G194S - In the laboratory mouse a Cys to Arg substitution at the site homologous to felid residue 125 causes constitutive activation of the receptor and the exact same change is thought to be responsible for melanism in the Alaska silver fox - therefore C125R is considered to be the likely causative alteration in the Geoffroy’s cat.	Leopardus geoffroyi Geoffroy's cat - (species)	Leopardus geoffroyi Geoffroy's cat - (species) D		MC1R	Leopardus geoffroyi Geoffroy's cat - (species)	Published - Accepted by Curator
MC1R	Coloration (feathers)	Coding, SNP	Meleagris gallopavo mexicana (subspecies) D	Domesticated	Candidate Gene	Vidal O; Viñas J; Pla C (2010) Variability of the melanocortin 1 receptor (MC1R) gene explains the segregation of the bronze locus [...]	GP00002299	MC1R Q01726	Morphology	c.364A>T p.I122F	Meleagris gallopavo mexicana (subspecies)	Meleagris gallopavo mexicana (subspecies) D		MC1R	Meleagris gallopavo mexicana (subspecies)	Published - Accepted by Curator
MC1R	Coloration (feathers)	2 Mutations: Coding SNP	Meleagris gallopavo mexicana (subspecies) D	Domesticated	Candidate Gene	Vidal O; Viñas J; Pla C (2010) Variability of the melanocortin 1 receptor (MC1R) gene explains the segregation of the bronze locus [...]	GP00002300	MC1R Q01726	Morphology	2 mutations	Meleagris gallopavo mexicana (subspecies)	Meleagris gallopavo mexicana (subspecies) D		MC1R	Meleagris gallopavo mexicana (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dürig N; Letko A; Lepori V ; et al. (2018) Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies.	GP00002301	MC1R Q01726	Morphology	2-bp deletion in the coding sequence c.816_817delCT N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Dreger DL; Schmutz SM (2010 Sep-Oct) A new mutation in MC1R explains a coat color phenotype in 2 "old" breeds: Saluki and Afghan hound.	GP00002303	MC1R Q01726	Morphology	c.233G>T p.G78V N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		MC1R	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MC1R	Coloration (feathers; eyes)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Candidate Gene	Dávila SG; Gil MG; Resino-Talaván P ; et al. (2014) Association between polymorphism in the melanocortin 1 receptor gene and E locus plumage color pheno[...]	GP00002390	MC1R Q01726	Morphology	the Arg213Cys mutation may be the cause of the loss or the decrease of function of the receptor to produce eumelanin	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		MC1R	Gallus gallus chicken - (species)	Published - Accepted by Curator
MC4R	Feeding behavior	Coding, SNP	Astyanax mexicanus Mexican tetra - (species)	Intraspecific	Linkage Mapping	Aspiras AC; Rohner N; Martineau B ; et al. (2015) Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditio[...]	GP00000637	mc4r B0V1P1	Behavior	Gly145Ser (candidate mutation)	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species)		MC4R	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
MDR1	Xenobiotic resistance	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Kimchi-Sarfaty C; Oh JM; Kim IW ; et al. (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity.	GP00001858	ABCB1 P08183	Physiology	C3435T - synonymous mutation Ile - The SNP at position 26/3435 that changes the codon from ATC to ATT (Ile) reduces the codon usage from 47% to 35% (RSCU values change from 20.9 to 15.8). Leads to similar mRNA and protein levels but altered conformation of the protein.	Homo sapiens human - (species)	Homo sapiens human - (species) D		MDR1	Homo sapiens human - (species)	Published - Accepted by Curator
MDS3	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000641	MDS3 P53094	Physiology	Phe - Val substitution	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MDS3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Li W; Sartelet A; Tamma N ; et al. (2016) Reverse genetic screen for loss-of-function mutations uncovers a frameshifting deletion in the melan[...]	GP00000642	Mlph Q91V27	Morphology	10bp deletion in exon1 ; c.87_96del p.Glu32Aspfs*1 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Melanophilin (MLPH)	Bos taurus cattle - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Bauer A; Kehl A; Jagannathan V ; et al. (2018) A novel MLPH variant in dogs with coat colour dilution.	GP00000643	Mlph Q91V27	Morphology	c.705G>C p.Gln235His	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Melanophilin (MLPH)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Ishida Y; David VA; Eizirik E ; et al. (2006) A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat[...]	GP00000644	Mlph Q91V27	Morphology	1bp deletion resulting in frameshift c.83delT N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		Melanophilin (MLPH)	Felis catus domestic cat - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Gallus gallus chicken - (species) D	Domesticated	Candidate Gene	Vaez M; Follett SA; Bed'hom B ; et al. (2008) A single point-mutation within the melanophilin gene causes the lavender plumage colour dilution phe[...]	GP00000645	Mlph Q91V27	Morphology	c.103C>T p.R35W	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Melanophilin (MLPH)	Gallus gallus chicken - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Cirera S; Markakis MN; Christensen K ; et al. (2013) New insights into the melanophilin (MLPH) gene controlling coat color phenotypes in American mink.	GP00000646	Mlph Q91V27	Morphology	deletion including intron 7 and exon 8 N	Neovison vison American mink - (species)	Neovison vison American mink - (species) D		Melanophilin (MLPH)	Neovison vison American mink - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Cirera S; Markakis MN; Christensen K ; et al. (2013) New insights into the melanophilin (MLPH) gene controlling coat color phenotypes in American mink. 1 Additional References Manakhov AD; Andreeva TV; Trapezov OV (2019) Genome analysis identifies the mutant genes for common industrial Silverblue and Hedlund white coat [...]	GP00000647	Mlph Q91V27	Morphology	Splice donor site variation in exon 8 resulting in a premature stop codon c.901+1G>A	Neovison vison American mink - (species)	Neovison vison American mink - (species) D		Melanophilin (MLPH)	Neovison vison American mink - (species)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Oryctolagus (genus) D	Domesticated	Candidate Gene	Fontanesi L; Scotti E; Allain D ; et al. (2014) A frameshift mutation in the melanophilin gene causes the dilute coat colour in rabbit (Oryctolagus [...]	GP00000648	Mlph Q91V27	Morphology	1bp deletion resulting in frameshift N	Oryctolagus (genus)	Oryctolagus (genus) D		Melanophilin (MLPH)	Oryctolagus (genus)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Oryctolagus (genus) D	Domesticated	Candidate Gene	Lehner S; Gähle M; Dierks C ; et al. (2013) Two-exon skipping within MLPH is associated with coat color dilution in rabbits.	GP00000649	Mlph Q91V27	Morphology	c.111-5C>A (exon skipping resulting in frameshift and truncated protein)	Oryctolagus (genus)	Oryctolagus (genus) D		Melanophilin (MLPH)	Oryctolagus (genus)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Linkage Mapping	Drögemüller C; Philipp U; Haase B ; et al. (2007) A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal[...]	GP00002330	Mlph Q91V27	Morphology	GA substitution at splice donor site causing Splicing defect	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Melanophilin (MLPH)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Van Buren SL; Minor KM; Grahn RA ; et al. (2020) A Third MLPH Variant Causing Coat Color Dilution in Dogs.	GP00002331	Mlph Q91V27	Morphology	c.667_668insC p.(His223Profs*41) N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Melanophilin (MLPH)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Melanophilin (MLPH)	Coloration (coat)	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Lehner S; Gähle M; Dierks C ; et al. (2013) Two-exon skipping within MLPH is associated with coat color dilution in rabbits.	GP00002332	Mlph Q91V27	Morphology	c.585delG p.L195LfsX123* N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		Melanophilin (MLPH)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
MFSD12	Coloration (coat)	Coding, Insertion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Tanaka J; Leeb T; Rushton J ; et al. (2019) Frameshift Variant in MFSD12 Explains the Mushroom Coat Color Dilution in Shetland Ponies.	GP00002243	MFSD12 Q6NUT3	Morphology	p.(Asp201fs) due to c.600Cins N	Equus caballus horse - (species)	Equus caballus horse - (species) D		MFSD12	Equus caballus horse - (species)	Published - Accepted by Curator
MFSD12	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Hédan B; Cadieu E; Botherel N ; et al. (2019) Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White[...]	GP00002244	MFSD12 Q6NUT3	Morphology	c.151C>T p.Arg51Cys N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		MFSD12	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
MFSD12	Coloration (skin)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Adhikari K; Mendoza-Revilla J; Sohail A ; et al. (2019) A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasi[...] 1 Additional References Crawford NG; Kelly DE; Hansen MEB (2017) Loci associated with skin pigmentation identified in African populations.	GP00002245	MFSD12 Q6NUT3	Morphology	Y182H N	Homo sapiens human - (species)	Homo sapiens human - (species) D		MFSD12	Homo sapiens human - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Haase B; Blatter M ; et al. (2012) Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.	GP00000659	Mitf Q08874	Morphology	c.629A>G N310S yielding defective DNA-binding	Equus caballus horse - (species)	Equus caballus horse - (species) D		Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (feathers)	Coding, Deletion N	Coturnix japonica Japanese quail - (species) D	Domesticated	Candidate Gene	Minvielle F; Bed'hom B; Coville JL ; et al. (2010) The "silver" Japanese quail and the MITF gene: causal mutation, associated traits and homology with [...] 1 Additional References Mochii M; Ono T; Matsubara Y (1998) Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in [...]	GP00000660	Mitf Q08874	Morphology	2bp deletion N	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species) D		Microphtalmia-associated transcription factor	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Haase B; Blatter M ; et al. (2012) Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.	GP00002322	Mitf Q08874	Morphology	c.519_523delGTGTC p.C174Sfs*20 N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Dürig N; Jude R; Jagannathan V ; et al. (2017) A novel MITF variant in a white American Standardbred foal.	GP00002323	Mitf Q08874	Morphology	c.731G>A p.G244E	Equus caballus horse - (species)	Equus caballus horse - (species) D		Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Henkel J; Lafayette C; Brooks SA ; et al. (2019) Whole-genome sequencing reveals a large deletion in the MITF gene in horses with white spotted coat [...]	GP00002324	Mitf Q08874	Morphology	~63-kb deletion spanning exons 6-9 N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Magdesian KG; Tanaka J; Bellone RR (2020) A De Novo MITF Deletion Explains a Novel Splashed White Phenotype in an American Paint Horse.	GP00002325	Mitf Q08874	Morphology	8.7 kb deletion N	Equus caballus horse - (species)	Equus caballus horse - (species) D		Microphtalmia-associated transcription factor	Equus caballus horse - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP N	Bubalus bubalis water buffalo - (species) D	Domesticated	Candidate Gene	Yusnizar Y; Wilbe M; Herlino AO ; et al. (2015) Microphthalmia-associated transcription factor mutations are associated with white-spotted coat colo[...]	GP00002327	Mitf Q08874	Morphology	c.328C>T p.R110* N	Bubalus bubalis water buffalo - (species)	Bubalus bubalis water buffalo - (species) D		Microphtalmia-associated transcription factor	Bubalus bubalis water buffalo - (species)	Published - Accepted by Curator
Microphtalmia-associated transcription factor	Coloration (coat)	Coding, SNP N	Bubalus bubalis water buffalo - (species) D	Domesticated	Candidate Gene	Yusnizar Y; Wilbe M; Herlino AO ; et al. (2015) Microphthalmia-associated transcription factor mutations are associated with white-spotted coat colo[...]	GP00002328	Mitf Q08874	Morphology	donor splice-site mutation leads to aberrant splicing of exon 8 that encodes part of a highly conserved region of MITF N	Bubalus bubalis water buffalo - (species)	Bubalus bubalis water buffalo - (species) D		Microphtalmia-associated transcription factor	Bubalus bubalis water buffalo - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Papio anubis olive baboon - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001452	MAVS Q7Z434	Physiology	Cys508Arg disrupting the protease cleavage site	Miopithecus talapoin talapoin - (species)	Papio anubis olive baboon - (species) D		Mitochondrial antiviral signaling (MAVS)	Papio anubis olive baboon - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Macaca mulatta Rhesus monkey - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001453	MAVS Q7Z434	Physiology	Val506Gly resistant to cleavage	Miopithecus talapoin talapoin - (species)	Macaca mulatta Rhesus monkey - (species) D		Mitochondrial antiviral signaling (MAVS)	Macaca mulatta Rhesus monkey - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Ateles geoffroyi black-handed spider monkey - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001454	MAVS Q7Z434	Physiology	Val506Ala resistant to cleavage	Lagothrix lagotricha brown woolly monkey - (species)	Ateles geoffroyi black-handed spider monkey - (species) D		Mitochondrial antiviral signaling (MAVS)	Ateles geoffroyi black-handed spider monkey - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Plecturocebus moloch red-bellied titi - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001455	MAVS Q7Z434	Physiology	Val506Ala resistant to cleavage	Lagothrix lagotricha brown woolly monkey - (species)	Plecturocebus moloch red-bellied titi - (species) D		Mitochondrial antiviral signaling (MAVS)	Plecturocebus moloch red-bellied titi - (species)	Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)	Pathogen resistance (hepaciviruses)	Coding, SNP	Allenopithecus nigroviridis Allen's swamp monkey - (species) D	Interspecific	Candidate Gene	Patel MR; Loo YM; Horner SM ; et al. (2012) Convergent evolution of escape from hepaciviral antagonism in primates.	GP00001456	MAVS Q7Z434	Physiology	Val506Met less susceptible to cleavage	Erythrocebus patas red guenon - (species)	Allenopithecus nigroviridis Allen's swamp monkey - (species) D		Mitochondrial antiviral signaling (MAVS)	Allenopithecus nigroviridis Allen's swamp monkey - (species)	Published - Accepted by Curator
mitochondrial tyrosine tRNA	Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013) An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...] 1 Additional References Hoekstra LA; Siddiq MA; Montooth KL (2013) Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect o[...]	GP00001971		Physiology	C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)	Drosophila simulans (species)	Drosophila simulans (species) D		mitochondrial tyrosine tRNA	Drosophila simulans (species)	Published - Accepted by Curator
MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)	Ozone sensitivity (stomata opening and stomatal CO2-sensitivity)	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Jakobson L; Vaahtera L; Tõldsepp K ; et al. (2016) Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO[...]	GP00001383	MPK12 Q8GYQ5	Physiology	G53R	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MKT1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000662	MKT1 P40850	Physiology	D30G (reversion; functionally verified); evolved independently in 3 lines	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MKT1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MKT1	Temperature tolerance Virulence Sporulation efficiency Sporulation efficiency Xenobiotic resistance (alcohol; ethanol) Xenobiotic resistance (genotoxic DNA-damage agent)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Steinmetz LM; Sinha H; Richards DR ; et al. (2002) Dissecting the architecture of a quantitative trait locus in yeast. 5 Additional References Sinha H; Nicholson BP; Steinmetz LM (2006) Complex genetic interactions in a quantitative trait locus. Demogines A; Smith E; Kruglyak L (2008) Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. Swinnen S; Schaerlaekens K; Pais T (2012) Identification of novel causative genes determining the complex trait of high ethanol tolerance in y[...] Ehrenreich IM; Torabi N; Jia Y (2010) Dissection of genetically complex traits with extremely large pools of yeast segregants. Deutschbauer AM; Davis RW (2005) Quantitative trait loci mapped to single-nucleotide resolution in yeast.	GP00000666	MKT1 P40850	Physiology Physiology Physiology Physiology Physiology Physiology	G30D (functionally verified); or haplotype including G30D (functionally verified)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		MKT1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Mla (=Sr33/AetRGA1e)	Pathogen resistance	Coding, Unknown	Aegilops tauschii (species)	Domesticated	Linkage Mapping	Periyannan S; Moore J; Ayliffe M ; et al. (2013) The gene Sr33, an ortholog of barley Mla genes, encodes resistance to wheat stem rust race Ug99.	GP00000667	Mla1 Q7EXP5	Physiology	Unknown	Triticum aestivum bread wheat - (species)	Aegilops tauschii (species)		Mla (=Sr33/AetRGA1e)	Aegilops tauschii (species)	Published - Accepted by Curator
Mla1	Pathogen resistance	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Mahadevappa M; Descenzo RA; Wise RP (1994) Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...] 3 Additional References Wei F; Gobelman-Werner K; Morroll SM (1999) The Mla (powdery mildew) resistance cluster is associated with three NBS-LRR gene families and suppr[...] Halterman D; Zhou F; Wei F (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...] Jordan T; Seeholzer S; Schwizer S (2011) The wheat Mla homologue TmMla1 exhibits an evolutionarily conserved function against powdery mildew [...]	GP00000668	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain - exact amino acid change unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		Mla1	Hordeum vulgare (species)	Published - Accepted by Curator
Mla1	Pathogen resistance	Coding, Unknown	Triticum monococcum (species)	Domesticated	Candidate Gene	Halterman D; Zhou F; Wei F ; et al. (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...] 1 Additional References Jordan T; Seeholzer S; Schwizer S (2011) The wheat Mla homologue TmMla1 exhibits an evolutionarily conserved function against powdery mildew [...]	GP00000669	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain	Triticum monococcum (species)	Triticum monococcum (species)		Mla1	Triticum monococcum (species)	Published - Accepted by Curator
Mla13	Pathogen resistance	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Mahadevappa M; Descenzo RA; Wise RP (1994) Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...] 2 Additional References Wei F; Gobelman-Werner K; Morroll SM (1999) The Mla (powdery mildew) resistance cluster is associated with three NBS-LRR gene families and suppr[...] Halterman D; Zhou F; Wei F (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...]	GP00000670	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain - exact amino acid change unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		Mla13	Hordeum vulgare (species)	Published - Accepted by Curator
Mla6	Pathogen resistance	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Mahadevappa M; Descenzo RA; Wise RP (1994) Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...] 2 Additional References Wei F; Gobelman-Werner K; Morroll SM (1999) The Mla (powdery mildew) resistance cluster is associated with three NBS-LRR gene families and suppr[...] Halterman D; Zhou F; Wei F (2001) The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...]	GP00000671	Mla1 Q7EXP5	Physiology	Coding variation in the LRR domain - exact amino acid change(s) unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		Mla6	Hordeum vulgare (species)	Published - Accepted by Curator
MLO1	Pathogen resistance	Coding, SNP N	Pisum sativum pea - (species)	Domesticated	Linkage Mapping	Pavan S; Schiavulli A; Appiano M ; et al. (2011) Pea powdery mildew er1 resistance is associated to loss-of-function mutations at a MLO homologous lo[...]	GP00000673	MLO P93766	Physiology	1bp substitution resulting in premature stop codon N	Pisum sativum pea - (species)	Pisum sativum pea - (species)		MLO1	Pisum sativum pea - (species)	Published - Accepted by Curator
MLO1	Pathogen resistance	Coding, Deletion N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Bai Y; Pavan S; Zheng Z ; et al. (2008) Naturally occurring broad-spectrum powdery mildew resistance in a Central American tomato accession [...]	GP00000674	MLO P93766	Physiology	19bp deletion resulting in frameshift N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D		MLO1	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
MNN4	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001711	MNN4 P36044	Physiology	Lys924Glu (A>G at position 64698 according to Table 1) - AAR to GAR position 64698	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MNN4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Molybdenum transporter1 (MOT1)	Metal tolerance	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Poormohammad Kiani S; Trontin C; Andreatta M ; et al. (2012) Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.	GP00001270	MOT1 Q9SL95	Physiology	D104Y	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		Molybdenum transporter1 (MOT1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MPK12	Water absorption (water use efficiency)	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Des Marais DL; Auchincloss LC; Sukamtoh E ; et al. (2014) Variation in MPK12 affects water use efficiency in Arabidopsis and reveals a pleiotropic link betwee[...]	GP00001283	MPK12 Q8GYQ5	Physiology	GGT to CGT @position 53	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		MPK12	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Mpv17	Coloration (albinism; iridophores)	Coding, Deletion N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002358	mpv17 Q5TZ51	Morphology; Physiology	Deletion which removes 16 amino acids in a conserved region. The Mpv17 mutant in zebrafish displays a strong reduction of iridophores throughout larval and adult stages. N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		Mpv17	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
MRC2	Muscular mass Tail shape (crooked ; defect)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Association Mapping	Fasquelle C; Sartelet A; Li W ; et al. (2009) Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Croo[...] 2 Additional References Sartelet A; Klingbeil P; Franklin CK (2012) Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection? Druet T; Ahariz N; Cambisano N (2014) Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian[...]	GP00002264	MRC2 Q9UBG0	Physiology Morphology	c.2904-2905delAG p.Gly934X N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		MRC2	Bos taurus cattle - (species)	Published - Accepted by Curator
MRC2	Muscular mass Tail shape (crooked ; defect)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Association Mapping	Fasquelle C; Sartelet A; Li W ; et al. (2009) Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Croo[...] 2 Additional References Sartelet A; Klingbeil P; Franklin CK (2012) Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection? Druet T; Ahariz N; Cambisano N (2014) Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian[...]	GP00002265	MRC2 Q9UBG0	Physiology Morphology	c.1906T>G p.C636G	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		MRC2	Bos taurus cattle - (species)	Published - Accepted by Curator
MRS1	F2 lethality	3 Mutations: Coding SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000678	MRS1 P07266	Physiology	3 mutations	Saccharomyces paradoxus (species) Saccharomyces bayanus (species) Saccharomyces kudriavzevii (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MRS1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00000679	CUP1-1 P0CX80	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
MTH1	Low-glucose adaptation (experimental evolution)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00000680	CUP1-1 P0CX80	Physiology	Ty retrotranposition resulting in a coding frameshift N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MTH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Domesticated	Linkage Mapping	Macquet A; Ralet MC; Loudet O ; et al. (2007) A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...]	GP00000681	BGAL6 Q9FFN4	Physiology	44bp deletion in exon 15; from Leu-662 onwards. This deletion causes a frame-shift mutation changing the next 23 amino acids followed by the introduction of a stop codon. N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001274	BGAL6 Q9FFN4	Physiology	C->T @position 2223 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001275	BGAL6 Q9FFN4	Physiology	G->C @position 2240 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001276	BGAL6 Q9FFN4	Physiology	G->T @position 3425 causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
mucilage-modified 2 (mum2)	Mucilage (seeds)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis.	GP00001277	BGAL6 Q9FFN4	Physiology	TACA insertion @position 4906 causing frame shift + Stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		mucilage-modified 2 (mum2)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
MUK1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001713	MUK1 Q02866	Physiology	Ser441STP(C>A at position 422266 according to Table 1) - TCR to TAR position 422266	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		MUK1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
multidrug resistance protein 2	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001532	PF3D7_1447900 Q8IKZ6	Physiology	p.Thr484Ile	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		multidrug resistance protein 2	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
MuPKS	Coloration (psittacofulvin; feathers)	Coding, SNP	Melopsittacus undulatus budgerigar - (species) D	Domesticated	Association Mapping	Cooke TF; Fischer CR; Wu P ; et al. (2017) Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars.	GP00002121	PKS15 A0A218V6J0	Morphology		Melopsittacus undulatus budgerigar - (species)	Melopsittacus undulatus budgerigar - (species) D		MuPKS	Melopsittacus undulatus budgerigar - (species)	Published - Accepted by Curator
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)	Glycogen content (muscles)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Linkage Mapping	Milan D; Jeon JT; Looft C ; et al. (2000) A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle.	GP00000682	Prkag3 Q8BGM7	Physiology	R200Q in CBS1; which is the most conserved region among AMPK g chain isoforms; and R200 is conserved in mammalian and Drosophila AMPK g isoforms	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D		Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)	Glycogen content (muscles)	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Candidate Gene	Ciobanu D; Bastiaansen J; Malek M ; et al. (2001) Evidence for new alleles in the protein kinase adenosine monophosphate-activated gamma(3)-subunit ge[...]	GP00002333	Prkag3 Q8BGM7	Physiology	p.(I249V)	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D		Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
MX1	Pathogen resistance (myxovirus)	Coding, SNP	Gallus gallus chicken - (species) D	Intraspecific		Ko JH; Jin HK; Asano A ; et al. (2002) Polymorphisms and the differential antiviral activity of the chicken Mx gene.	GP00002249	MX1 P20591	Physiology	c.1892G>A p.S631N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		MX1	Gallus gallus chicken - (species)	Published - Accepted by Curator
MYB-FL	Coloration (flower ; UV absorbance)	Coding, Deletion N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Sheehan H; Moser M; Klahre U ; et al. (2016) MYB-FL controls gain and loss of floral UV absorbance, a key trait affecting pollinator preference a[...]	GP00001590	MYB-FL A0A0S3CVC7	Morphology	A 1-bp deletion in exon 3 causing a frameshift resulting in a truncated protein N	Petunia axillaris (species)	Petunia exserta (species) D		MYB-FL	Petunia exserta (species)	Published - Accepted by Curator
MYB1	Coloration (flower)	Coding, Deletion N	Ipomoea purpurea common morning-glory - (species) D	Intraspecific	Candidate Gene	Chang SM; Lu Y; Rausher MD (2005) Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea.	GP00001458	myb1 Q4QS21	Morphology	2 deletions; 6-bp and 19-bp long; the larger produces a frameshift and a premature stop N	Ipomoea purpurea common morning-glory - (species)	Ipomoea purpurea common morning-glory - (species) D		MYB1	Ipomoea purpurea common morning-glory - (species)	Published - Accepted by Curator
MYB1	Coloration (flowers; seeds; stems)	Coding, Deletion N	Ipomoea nil Japanese morning glory - (species) D	Domesticated	Candidate Gene	Morita Y; Saitoh M; Hoshino A ; et al. (2006) Isolation of cDNAs for R2R3-MYB, bHLH and WDR transcriptional regulators and identification of c and[...]	GP00002089	myb1 Q4QS21	Morphology	frameshift mutation caused by a 2 bp deletion N	Ipomoea nil Japanese morning glory - (species)	Ipomoea nil Japanese morning glory - (species) D		MYB1	Ipomoea nil Japanese morning glory - (species)	Published - Accepted by Curator
myosin heavy chain 16 (MYH16)	Masticatory muscles	Coding, Deletion N	Homo sapiens human - (species) D	Intergeneric or Higher	Candidate Gene	Stedman HH; Kozyak BW; Nelson A ; et al. (2004) Myosin gene mutation correlates with anatomical changes in the human lineage.	GP00000683	MYH16 Q9H6N6	Morphology	2bp deletion at codon 660 N	Pan troglodytes chimpanzee - (species)	Homo sapiens human - (species) D		myosin heavy chain 16 (MYH16)	Homo sapiens human - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Grobet L; Martin LJ; Poncelet D ; et al. (1997) A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. 2 Additional References McPherron AC; Lee SJ (1997) Double muscling in cattle due to mutations in the myostatin gene. Kambadur R; Sharma M; Smith TP (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.	GP00000685	MSTN O14793	Morphology	nt821 11bp deletion c.821-831delTGAACACTCCA p.Glu275ArgfsX14 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Indel N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000686	MSTN O14793	Morphology	nt419 7bp deletion and 10bp insertion; leading to a premature stop codon at position 140 c.419_425del7, c418_426ins10 N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000687	MSTN O14793	Morphology	c.610C>T p.Q204* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Grobet L; Poncelet D; Royo LJ ; et al. (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...]	GP00000688	MSTN O14793	Morphology	E226* caused by G676T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	McPherron AC; Lee SJ (1997) Double muscling in cattle due to mutations in the myostatin gene. 2 Additional References Grobet L; Poncelet D; Royo LJ (1998) Molecular definition of an allelic series of mutations disrupting the myostatin function and causing[...] Kambadur R; Sharma M; Smith TP (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.	GP00000689	MSTN O14793	Morphology	C313Y caused by G938A; disrupts disulphide bond	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Marchitelli C; Savarese MC; Crisà A ; et al. (2003) Double muscling in Marchigiana beef breed is caused by a stop codon in the third exon of myostatin g[...]	GP00000690	MSTN O14793	Morphology	E291* caused by G>T N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Alexander LJ; Kuehn LA; Smith TP ; et al. (2009) A Limousin specific myostatin allele affects longissimus muscle area and fatty acid profiles in a Wa[...]	GP00000692	MSTN O14793	Morphology	c.282C>A p.Phe94Leu	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Boman IA; Klemetsdal G; Blichfeldt T ; et al. (2009) A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation[...]	GP00000693	MSTN O14793	Morphology	1bp deletion resulting in a premature stop codon at position 320 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		Myostatin (MSTN = GDF8)	Ovis aries sheep - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, Insertion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Boman IA; Våge DI (2009) An insertion in the coding region of the myostatin (MSTN) gene affects carcass conformation and fatn[...]	GP00000694	MSTN O14793	Morphology	1bp insertion resulting in premature stop codon at position 49 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		Myostatin (MSTN = GDF8)	Ovis aries sheep - (species)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Racing performance	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Mosher DS; Quignon P; Bustamante CD ; et al. (2007) A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygo[...]	GP00000697	MSTN O14793	Morphology; Physiology	2bp deletion in the third exon c.939_940delTG p.C313* N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		Myostatin (MSTN = GDF8)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Myostatin (MSTN = GDF8)	Muscular mass (double muscling)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Dierks C; Eder J; Glatzer S ; et al. (2015) A novel myostatin mutation in double-muscled German Gelbvieh.	GP00002248	MSTN O14793	Morphology	c.191T>C p.L64P	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Myostatin (MSTN = GDF8)	Bos taurus cattle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Varanus salvator water monitor - (species) D Varanus niloticus (species) D Varanus albigularis cape monitor - (species) D	Interspecific	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000699	Atp1a1 Q8VDN2	Physiology	2 mutations	Varanus tristis (species) Varanus mitchelli (species) Varanus scalaris (species)	Varanus salvator water monitor - (species) D Varanus niloticus (species) D Varanus albigularis cape monitor - (species) D		Na/K-ATPase alpha-subunit	Varanus salvator water monitor - (species) Varanus niloticus (species) Varanus albigularis cape monitor - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Natricinae (subfamily) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000700	Atp1a1 Q8VDN2	Physiology	2 mutations	Colubridae colubrid snakes - (family)	Natricinae (subfamily) D		Na/K-ATPase alpha-subunit	Natricinae (subfamily)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Leptodactylus ocellatus argus frog - (species) D	Intraspecific	Candidate Gene	Moore DJ; Halliday DC; Rowell DM ; et al. (2009) Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000701	Atp1a1 Q8VDN2	Physiology	2 mutations	Leptodactylus ocellatus argus frog - (species)	Leptodactylus ocellatus argus frog - (species) D		Na/K-ATPase alpha-subunit	Leptodactylus ocellatus argus frog - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Atelopus spumarius Pebas stubfoot toad - (species) D Rhinella marina marine toad - (species) D Rhinella granulosa granular toad - (species) D	Intergeneric or Higher	Candidate Gene	Moore DJ; Halliday DC; Rowell DM ; et al. (2009) Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000702	Atp1a1 Q8VDN2	Physiology	2 mutations	Hyloidea (superfamily)	Atelopus spumarius Pebas stubfoot toad - (species) D Rhinella marina marine toad - (species) D Rhinella granulosa granular toad - (species) D		Na/K-ATPase alpha-subunit	Atelopus spumarius Pebas stubfoot toad - (species) Rhinella marina marine toad - (species) Rhinella granulosa granular toad - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Naja melanoleuca forest cobra - (species) D Naja naja Indian cobra - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000703	Atp1a1 Q8VDN2	Physiology	2 mutations	Ophiophagus hannah king cobra - (species) Pseudechis australis mulga snake - (species) Hemiaspis signata (species)	Naja melanoleuca forest cobra - (species) D Naja naja Indian cobra - (species) D		Na/K-ATPase alpha-subunit	Naja melanoleuca forest cobra - (species) Naja naja Indian cobra - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	4 Mutations: Coding SNP	Chrysochus auratus dogbane beetle - (species) D	Interspecific	Candidate Gene	Aardema ML; Zhen Y; Andolfatto P (2012) The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies. 1 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000704	Atp1a1 Q8VDN2	Physiology	4 mutations	Coleoptera beetles - (order)	Chrysochus auratus dogbane beetle - (species) D		Na/K-ATPase alpha-subunit	Chrysochus auratus dogbane beetle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Rhyssomatus lineaticollis (species) D	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community.	GP00000705	K+ ATPase alpha subunit R4ZHW8	Physiology	C104Y	Coleoptera beetles - (order)	Rhyssomatus lineaticollis (species) D		Na/K-ATPase alpha-subunit	Rhyssomatus lineaticollis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Tetraopes tetrophthalmus red milkweed beetle - (species) D	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000706	Atp1a1 Q8VDN2	Physiology	2 mutations	Coleoptera beetles - (order)	Tetraopes tetrophthalmus red milkweed beetle - (species) D		Na/K-ATPase alpha-subunit	Tetraopes tetrophthalmus red milkweed beetle - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides; ouabaine)	4 Mutations: Coding SNP	Danaus plexippus monarch butterfly - (species) D Danaus erippus (species) D	Interspecific	Candidate Gene	Aardema ML; Zhen Y; Andolfatto P (2012) The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies. 3 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] Taverner AM; Yang L; Barile ZJ (2019) Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vi[...] Karageorgi M; Groen SC; Sumbul F (2019) Genome editing retraces the evolution of toxin resistance in the monarch butterfly.	GP00000707	Atp1a1 Q8VDN2	Physiology	4 mutations	Nymphalidae brushfoots - (family)	Danaus plexippus monarch butterfly - (species) D Danaus erippus (species) D		Na/K-ATPase alpha-subunit	Danaus plexippus monarch butterfly - (species) Danaus erippus (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Erinaceus europaeus western European hedgehog - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000708	Atp1a1 Q8VDN2	Physiology	2 mutations	Condylura cristata star-nosed mole - (species)	Erinaceus europaeus western European hedgehog - (species) D		Na/K-ATPase alpha-subunit	Erinaceus europaeus western European hedgehog - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	4 Mutations: Coding SNP	Oncopeltus fasciatus milkweed bug - (species) D Lygaeus kalmii (species) D	Intergeneric or Higher	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] 2 Additional References Zhen Y; Aardema ML; Medina EM (2012) Parallel molecular evolution in an herbivore community. Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000709	Atp1a1 Q8VDN2	Physiology	4 mutations	Insecta true insects - (class)	Oncopeltus fasciatus milkweed bug - (species) D Lygaeus kalmii (species) D		Na/K-ATPase alpha-subunit	Oncopeltus fasciatus milkweed bug - (species) Lygaeus kalmii (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Labidomera clivicollis (species) D	Intergeneric or Higher	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] 1 Additional References Zhen Y; Aardema ML; Medina EM (2012) Parallel molecular evolution in an herbivore community.	GP00000710	Atp1a1 Q8VDN2	Physiology	2 mutations	Insecta true insects - (class)	Labidomera clivicollis (species) D		Na/K-ATPase alpha-subunit	Labidomera clivicollis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Liriomyza asclepiadis (species) D	Interspecific	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00000711	Atp1a1 Q8VDN2	Physiology	N122H	Insecta true insects - (class)	Liriomyza asclepiadis (species) D		Na/K-ATPase alpha-subunit	Liriomyza asclepiadis (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Aphis nerii oleander aphid - (species)	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community.	GP00000712	K+ ATPase alpha subunit R4ZHW8	Physiology	2 mutations	Insecta true insects - (class)	Aphis nerii oleander aphid - (species)		Na/K-ATPase alpha-subunit	Aphis nerii oleander aphid - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)	Interspecific	Candidate Gene	Zhen Y; Aardema ML; Medina EM ; et al. (2012) Parallel molecular evolution in an herbivore community. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000713	Atp1a1 Q8VDN2	Physiology	Q111L	Lepidoptera butterflies and moths - (order)	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)		Na/K-ATPase alpha-subunit	Cycnia tenera delicate cyncia - (species) Lerina incarnata (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Murinae (subfamily) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000714	Atp1a1 Q8VDN2	Physiology	2 mutations	Rodentia rodent - (order)	Murinae (subfamily) D		Na/K-ATPase alpha-subunit	Murinae (subfamily)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Varanus varius lace monitor - (species) D Varanus tristis (species) D Varanus scalaris (species) D	Interspecific	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000715	Atp1a1 Q8VDN2	Physiology	2 mutations	Varanus salvator water monitor - (species) Varanus rudicollis roughneck monitor - (species) Varanus dumerilii Dumeril monitor - (species)	Varanus varius lace monitor - (species) D Varanus tristis (species) D Varanus scalaris (species) D		Na/K-ATPase alpha-subunit	Varanus varius lace monitor - (species) Varanus tristis (species) Varanus scalaris (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Bitis arietans puff adder - (species) D Bitis nasicornis rhinoceros viper - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00000716	Atp1a1 Q8VDN2	Physiology	2 mutations	Vipera berus adder - (species)	Bitis arietans puff adder - (species) D Bitis nasicornis rhinoceros viper - (species) D		Na/K-ATPase alpha-subunit	Bitis arietans puff adder - (species) Bitis nasicornis rhinoceros viper - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, Unknown	Hydra vulgaris (species) D	Intergeneric or Higher	Candidate Gene	Canfield VA; Xu KY; D'Aquila T ; et al. (1992) Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme e[...]	GP00001738	Atp1a1 Q8VDN2	Physiology		Eumetazoa (no rank)	Hydra vulgaris (species) D		Na/K-ATPase alpha-subunit	Hydra vulgaris (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	2 Mutations: Coding SNP	Rattus norvegicus Norway rat - (species) D Mus musculus house mouse - (species) D Mesocricetus auratus golden hamster - (species) D Peromyscus maniculatus North American deer mouse - (species) D Nannospalax galili Upper Galilee mountains blind mole rat - (species) D	Intergeneric or Higher	Candidate Gene	Shull GE; Greeb J; Lingrel JB (1986) Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00001739	Atp1a1 Q8VDN2	Physiology	2 mutations	Jaculus jaculus lesser Egyptian jerboa - (species) Spermophilus old world ground squirrels - (genus)	Rattus norvegicus Norway rat - (species) D Mus musculus house mouse - (species) D Mesocricetus auratus golden hamster - (species) D Peromyscus maniculatus North American deer mouse - (species) D Nannospalax galili Upper Galilee mountains blind mole rat - (species) D		Na/K-ATPase alpha-subunit	Rattus norvegicus Norway rat - (species) Mus musculus house mouse - (species) Mesocricetus auratus golden hamster - (species) Peromyscus maniculatus North American deer mouse - (species) Nannospalax galili Upper Galilee mountains blind mole rat - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Oncopeltus fasciatus milkweed bug - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution. 1 Additional References Dobler S; Dalla S; Wagschal V (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]	GP00001740	Atp1a1 Q8VDN2	Physiology	Q111T	Lygaeus kalmii (species)	Oncopeltus fasciatus milkweed bug - (species) D		Na/K-ATPase alpha-subunit	Oncopeltus fasciatus milkweed bug - (species)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Liriomyza (genus) D	Interspecific	Candidate Gene	Dobler S; Dalla S; Wagschal V ; et al. (2012) Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...] 1 Additional References Ujvari B; Casewell NR; Sunagar K (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00001741	Atp1a1 Q8VDN2	Physiology	Q111L	Phytomyzinae (subfamily)	Liriomyza (genus) D		Na/K-ATPase alpha-subunit	Liriomyza (genus)	Published - Accepted by Curator
Na/K-ATPase alpha-subunit	Xenobiotic resistance (cardiac glycosides)	Coding, SNP	Saucrobotys futilalis dogbane pyralid moth - (species) D	Intergeneric or Higher	Candidate Gene	Ujvari B; Casewell NR; Sunagar K ; et al. (2015) Widespread convergence in toxin resistance by predictable molecular evolution.	GP00001742	Atp1a1 Q8VDN2	Physiology	Q111L	Holometabola (cohort)	Saucrobotys futilalis dogbane pyralid moth - (species) D		Na/K-ATPase alpha-subunit	Saucrobotys futilalis dogbane pyralid moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Wang ZJ; Liang CR; Shang ZY ; et al. (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]	GP00002491	nAChRbeta1 P04755	Physiology	R81T	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		nAChR	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Wang ZJ; Liang CR; Shang ZY ; et al. (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]	GP00002492	nAChRbeta1 P04755	Physiology	K264E	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		nAChR	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Puinean AM; Andrews M ; et al. (2011) Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotin[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]	GP00002553	nAChRbeta1 P04755	Physiology	R81T in the loop D region of the nAChR β1 subunit of the resistant clone	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		nAChR	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad; spirotetramat)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Puinean AM; Lansdell SJ; Collins T ; et al. (2013) A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance t[...] 3 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Sun LN; Shen XJ; Cao LJ (2022) Increasing Frequency of G275E Mutation in the Nicotinic Acetylcholine Receptor α6 Subunit Conferring[...] Zimmer CT; Garrood WT; Puinean AM (2016) A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor[...]	GP00002554	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		nAChR	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao WX; Narai Y; Nakano A ; et al. (2014) Spinosad resistance of melon thrips, Thrips palmi, is conferred by G275E mutation in α6 subunit of n[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002555	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Thrips palmi (species)	Thrips palmi (species) D		nAChR	Thrips palmi (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Xu X; Ding Q; Wang X ; et al. (2022) V101I and R81T mutations in the nicotinic acetylcholine receptor β1 subunit are associated with neon[...]	GP00002612	nAChRbeta1 P04755	Physiology	V101I	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		nAChR	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Silva WM; Berger M; Bass C ; et al. (2016) Mutation (G275E) of the nicotinic acetylcholine receptor α6 subunit is associated with high levels o[...] 1 Additional References Zimmer CT; Garrood WT; Puinean AM (2016) A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor[...]	GP00002621	nAChRbeta1 P04755	Physiology	G275E in nAchR alpha 6 due to a single nucleotide change	Tuta absoluta (species)	Tuta absoluta (species) D		nAChR	Tuta absoluta (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Unknown N	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Feng HT; Wu WJ ; et al. (2012) Truncated transcripts of nicotinic acetylcholine subunit gene Bdα6 are associated with spinosad resi[...]	GP00002650	CHRNA6 Q15825	Physiology	Mutation in Bdα6 intron 2 (A change to T) just before the truncated/mis-splicing region and in same location with a mutation previously reported in the Pxylα6 gene. Small deletions and insertions leading to premature stop codons in exon 7. N	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D		nAChR	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, SNP N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Chen M; Dawson A ; et al. (2010) Mis-spliced transcripts of nicotinic acetylcholine receptor alpha6 are associated with field evolved[...]	GP00002651	CHRNA6 Q15825	Physiology	A mutation within the ninth intron splice junction of Pxalpha6 results in mis-splicing of transcripts and produce a predicted protein truncated between the third and fourth transmembrane domains. N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		nAChR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Chen M; Shelton AM ; et al. (2010) Transcripts of the nicotinic acetylcholine receptor subunit gene Pxylα6 with premature stop codons a[...]	GP00002652	CHRNA6 Q15825	Physiology	transcripts with premature stop codons N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		nAChR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Experimental Evolution	Candidate Gene	Wang J; Wang X; Lansdell SJ ; et al. (2016) A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 s[...]	GP00002653	CHRNA6 Q15825	Physiology	a three amino acid (3-aa) deletion in the fourth transmembrane domain (TM4) of the nAChR α6 subunit N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		nAChR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
nAChR	Xenobiotic resistance (insecticide; spinosad)	Coding, Deletion N	Rhyzopertha dominica lesser grain borer - (species) D	Intraspecific	Candidate Gene	Wang HT; Tsai CL; Chen ME (2018) Nicotinic acetylcholine receptor subunit α6 associated with spinosad resistance in Rhyzopertha domin[...]	GP00002654	CHRNA6 Q15825	Physiology	Three mutations were found in the resistant strain compared with the susceptible one: (1) a 181-bp fragment truncated at the N-terminus resulting in the appearance of a premature stop codon - (2) one missing bp at the position 997 causing a frame-shift mutation and (3) an 87-bp fragment truncated in the TM2 region. N	Rhyzopertha dominica lesser grain borer - (species)	Rhyzopertha dominica lesser grain borer - (species) D		nAChR	Rhyzopertha dominica lesser grain borer - (species)	Published - Accepted by Curator
NAM-B1 (=Gpc-B1)	Grain content Senescence (grain)	Coding, Insertion N	Triticum turgidum (species) D	Domesticated	Linkage Mapping	Uauy C; Distelfeld A; Fahima T ; et al. (2006) A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat.	GP00000717	NAM-B1 A0SPJ4	Physiology Physiology	1bp insertion resulting in frameshift N	Triticum turgidum (species)	Triticum turgidum (species) D		NAM-B1 (=Gpc-B1)	Triticum turgidum (species)	Published - Accepted by Curator
nath-10	Fertility (sperm number; egg laying rate)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Duveau F; Félix MA (2012) Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.	GP00000718	nath-10 O01757	Morphology	Met746Ile (according to Table S2 C>T but it should be G>A - Needs curation)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		nath-10	Caenorhabditis elegans (species)	Published - Accepted by Curator
Nav1 sodium channel	Xenobiotic resistance (pyrethroid; tau-fluvalinate)	3 Mutations: Coding SNP	Bombus impatiens common eastern bumble bee - (species) D Apis mellifera honey bee - (species) D Dufourea novaeangliae (species) D Eufriesea mexicana (species) D Habropoda laboriosa (species) D Melipona quadrifasciata (species) D Megachile rotundata alfalfa leafcutting bee - (species) D Athalia rosae coleseed sawfly - (species) D	Intergeneric or Higher	Candidate Gene	Wu S; Nomura Y; Du Y ; et al. (2017) Molecular basis of selective resistance of the bumblebee BiNa1 sodium channel to tau-fluvalinate.	GP00002648	SCN8A Q9UQD0	Physiology	3 mutations	Polistes dominula European paper wasp - (species) Orussus abietinus (species) Diachasma alloeum (species)	Bombus impatiens common eastern bumble bee - (species) D Apis mellifera honey bee - (species) D Dufourea novaeangliae (species) D Eufriesea mexicana (species) D Habropoda laboriosa (species) D Melipona quadrifasciata (species) D Megachile rotundata alfalfa leafcutting bee - (species) D Athalia rosae coleseed sawfly - (species) D		Nav1 sodium channel	Bombus impatiens common eastern bumble bee - (species) Apis mellifera honey bee - (species) Dufourea novaeangliae (species) Eufriesea mexicana (species) Habropoda laboriosa (species) Melipona quadrifasciata (species) Megachile rotundata alfalfa leafcutting bee - (species) Athalia rosae coleseed sawfly - (species)	Published - Accepted by Curator
Nav1.6 sodium channel	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000735	SCN8A Q9UQD0	Physiology	Ile1709Val	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D		Nav1.6 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
Nav1.7 sodium channel	Xenobiotic resistance (TTX)	4 Mutations: Coding SNP	Thamnophis sirtalis (species) D	Intraspecific	Candidate Gene	McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014) Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]	GP00000736	SCN9A Q15858	Physiology	4 mutations	Thamnophis sirtalis (species)	Thamnophis sirtalis (species) D		Nav1.7 sodium channel	Thamnophis sirtalis (species)	Published - Accepted by Curator
ndp (norrin)	Coloration (plumage)	Coding, SNP N	Columba livia rock pigeon - (species) D	Domesticated	Association Mapping	Vickrey AI; Bruders R; Kronenberg Z ; et al. (2018) Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity i[...]	GP00002250	Ndp P48744	Morphology	Start-codon change predicted to truncate the amino terminus of the NDP protein by 11 amino acids thereby disrupting the 24-amino acid signal peptide sequence N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		ndp (norrin)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
Neverland	Cholesterol metabolism Ecological specialization	4 Mutations: Coding SNP	Drosophila pachea (species) D	Interspecific	Candidate Gene	Lang M; Murat S; Clark AG ; et al. (2012) Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.	GP00000738	nvd Q1JUZ1	Physiology Physiology	4 mutations	Drosophila acanthoptera (species)	Drosophila pachea (species) D	Courtier Virginie	Neverland	Drosophila pachea (species)	Published - Accepted by Curator	would be good to add text	March 8, 2019 10:00
Not much yang (Nmy)	Sex determination (sex ratio distortion)	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Tao Y; Masly JP; Araripe L ; et al. (2007) A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor. 1 Additional References Tao Y; Araripe L; Kingan SB (2007) A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.	GP00001970		Physiology	Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus and loss of most of the sequence located between the inverted repeats (except for a 93bp element in reverse orientation).	Drosophila simulans (species)	Drosophila simulans (species) D		Not much yang (Nmy)	Drosophila simulans (species)	Published - Accepted by Curator
npr-1	Aggregation behavior Foraging behavior CO2 avoidance Pathogen avoidance Fertility (competitive fitness)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	de Bono M; Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in[...] 5 Additional References Gloria-Soria A; Azevedo RB (2008) npr-1 Regulates foraging and dispersal strategies in Caenorhabditis elegans. Andersen EC; Bloom JS; Gerke JP (2014) A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth[...] McGrath PT; Rockman MV; Zimmer M (2009) Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...] Reddy KC; Andersen EC; Kruglyak L (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Burga A; Ben-David E; Lemus Vergara T (2019) Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk.	GP00000739	npr-1 Q18534	Behavior Behavior Behavior Behavior Behavior; Physiology	Val215Phe (pleiotropic; see other entries)	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		npr-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Nramp aluminum transporter1	Metal tolerance	2 Mutations: Coding SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Famoso AN; Zhao K; Clark RT ; et al. (2011) Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide ass[...]	GP00000740	NRAT1 Q6ZG85	Physiology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Nramp aluminum transporter1	Oryza sativa rice - (species)	Published - Accepted by Curator
NRT1.1B	Nitrogen use (metabolism)	Coding, SNP	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Hu B; Wang W; Ou S ; et al. (2015) Variation in NRT1.1B contributes to nitrate-use divergence between rice subspecies.	GP00001375	NPF6.3 Q05085	Physiology	c.980C>T p.Met327Thr	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		NRT1.1B	Oryza sativa rice - (species)	Published - Accepted by Curator
Nup160	Hybrid incompatibility (F1 male sterility)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Tang S; Presgraves DC (2009) Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.	GP00000742	Nup160 Q9VKJ3	Physiology	Coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Nup160	Drosophila simulans (species)	Published - Accepted by Curator
Nup96	Hybrid incompatibility (F1 male sterility)	Coding, Unknown	Drosophila simulans (species)	Interspecific	Linkage Mapping	Presgraves DC; Balagopalan L; Abmayr SM ; et al. (2003) Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.	GP00000743	NUP96 Q8LLD0	Physiology	Coding divergence	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Nup96	Drosophila simulans (species)	Published - Accepted by Curator
nurf-1	Fertility (reproductive timing; egg laying rate) Lifespan Growth rate Diapause (dauer formation)	Coding, Deletion	Caenorhabditis elegans (species) D	Domesticated	Linkage Mapping	Large EE; Xu W; Zhao Y ; et al. (2016) Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticate[...]	GP00001318	nurf-1 Q6BER5	Physiology Physiology Physiology Physiology	60bp deletion	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		nurf-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000745	Oca2 Q62052	Morphology Physiology	Deletion of exon 21 N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism) Catecholamine metabolism	Coding, Deletion N	Astyanax mexicanus Mexican tetra - (species) D	Intraspecific	Linkage Mapping	Protas ME; Hersey C; Kochanek D ; et al. (2006) Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. 2 Additional References Bilandžija H; Abraham L; Ma L (2018) Behavioural changes controlled by catecholaminergic systems explain recurrent loss of pigmentation i[...] Klaassen H; Wang Y; Adamski K (2018) CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus.	GP00000746	Oca2 Q62052	Morphology Physiology	Almost complete deletion of exon 24; + 2 a.a subsitutions at conserved positions - the two point mutations do not drastically affect the function of OCA2 in cell lines suggesting that the exon 24 deletion is the mutation that causes albinism in the Pachón population N	Astyanax mexicanus Mexican tetra - (species)	Astyanax mexicanus Mexican tetra - (species) D		Oca2	Astyanax mexicanus Mexican tetra - (species)	Published - Accepted by Curator
Oca2	Coloration (skin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Edwards M; Bigham A; Tan J ; et al. (2010) Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: furth[...] 1 Additional References Yang Z; Zhong H; Chen J (2016) A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution.	GP00000748	Oca2 Q62052	Morphology	His615Arg	Homo sapiens human - (species)	Homo sapiens human - (species) D		Oca2	Homo sapiens human - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Insertion N	Pantherophis guttatus (species) D	Intraspecific	Linkage Mapping	Saenko SV; Lamichhaney S; Martinez Barrio A ; et al. (2015) Amelanism in the corn snake is associated with the insertion of an LTR-retrotransposon in the OCA2 g[...]	GP00001619	OCA2 Q04671	Morphology	insertion of an LTR-retrotransposon (5832-bp) in the 11th intron resulting after splicing in an additional 397-bp fragment constituted of 3 new exons inserted between exons 11 and 12. Generates truncated protein with two stop codons N	Pantherophis guttatus (species)	Pantherophis guttatus (species) D		Oca2	Pantherophis guttatus (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Deletion N	Melanochromis auratus (species) D	Intraspecific	Candidate Gene	Kratochwil CF; Urban S; Meyer A (2019) Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an ame[...]	GP00001955	Oca2 Q62052	Morphology	deletion covering a total of 5.4kb including exon 2 and parts of the flanking introns 1 and 2 N	Melanochromis auratus (species)	Melanochromis auratus (species) D		Oca2	Melanochromis auratus (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Insertion N	Carassius auratus goldfish - (species) D	Domesticated	Candidate Gene	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002351	Oca2 Q62052	Morphology	1-bp insert creating a frameshift and a truncated protein (470 amino acids instead of 805). In oca2L ohnolog on chromosome LG6. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D		Oca2	Carassius auratus goldfish - (species)	Published - Accepted by Curator
Oca2	Coloration (albinism)	Coding, Deletion N	Carassius auratus goldfish - (species) D	Domesticated	Candidate Gene	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002352	Oca2 Q62052	Morphology	1-bp deletion creating a frameshift and a truncated protein (519 amino acids instead of 805). In oca2S ohnolog on chromosome LG31. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D		Oca2	Carassius auratus goldfish - (species)	Published - Accepted by Curator
ocimene synthase (OS)	Pheromone production (cuticular hydrocarbons ; beta-ocimene)	Coding, Unknown	Heliconius cydno (species) D	Interspecific	Linkage Mapping	Darragh K; Orteu A; Black D ; et al. (2021) A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between close[...]	GP00002426	TPS A0A7D0AGU9	Physiology	gain of expression - in vitro assay of the protein activity in E. coli - several amino acid changes between the 2 species	Heliconius melpomene postman butterfly - (species)	Heliconius cydno (species) D		ocimene synthase (OS)	Heliconius cydno (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, SNP N	Erythranthe cardinalis (species) D	Interspecific	Linkage Mapping	Byers KJ; Vela JP; Peng F ; et al. (2014) Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...] 1 Additional References Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001760	TPS02 P0CJ43	Physiology	multiple candidate coding sequence differences - together they eliminate the ability of the enzyme to produce E-beta-ocimene - effect of individual mutations not tested N	Erythranthe lewisii (species)	Erythranthe cardinalis (species) D		OCYMENE SYNTHASE (OS)	Erythranthe cardinalis (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, Deletion N	Erythranthe verbenacea (species) D	Interspecific	Candidate Gene	Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001762	TPS02 P0CJ43	Physiology	large deletion from the third exon to the last exon N	Erythranthe lewisii (species)	Erythranthe verbenacea (species) D		OCYMENE SYNTHASE (OS)	Erythranthe verbenacea (species)	Published - Accepted by Curator
OCYMENE SYNTHASE (OS)	Fragrance (floral terpenoid volatiles; E- beta-ocimene)	Coding, Insertion N	Erythranthe bicolor (species) D	Interspecific	Candidate Gene	Peng F; Byers KJRP; Bradshaw HD (2017) Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]	GP00001763	TPS02 P0CJ43	Physiology	2-bp insertion in the second exon, producing a frameshift mutation and premature termination N	Erythranthe lewisii (species)	Erythranthe bicolor (species) D		OCYMENE SYNTHASE (OS)	Erythranthe bicolor (species)	Published - Accepted by Curator
Odorant receptor 3 (OR3)	Olfactory behavior (pheromone)	Coding, SNP	Ostrinia furnacalis Asian corn borer - (species)	Interspecific	Candidate Gene	Leary GP; Allen JE; Bunger PL ; et al. (2012) Single mutation to a sex pheromone receptor provides adaptive specificity between closely related mo[...]	GP00000749	OR3 D3J5H6	Behavior	A148T	Ostrinia nubilalis European corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species)		Odorant receptor 3 (OR3)	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
opaque2 (O2)	Lysine content (endosperm)	Coding, Deletion N	Zea mays (species) D	Domesticated	Linkage Mapping	Schmidt RJ; Burr FA; Burr B (1987) Transposon tagging and molecular analysis of the maize regulatory locus opaque-2. 1 Additional References Hartings H; Lazzaroni N; Rossi V (1995) Molecular analysis of opaque-2 alleles from Zea mays L. reveals the nature of mutational events and [...]	GP00000753	O2 P12959	Physiology	1bp deletion predicted to cause premature termination of translation N	Zea mays (species)	Zea mays (species) D		opaque2 (O2)	Zea mays (species)	Published - Accepted by Curator
opsin	Color vision (blue)	Coding, SNP	Alloteuthis subulata (species)	Interspecific	Candidate Gene	Morris A; Bowmaker JK; Hunt DM (1993) The molecular basis of a spectral shift in the rhodopsins of two species of squid from different pho[...]	GP00000755	opn1sw1 Q9W6A9	Physiology	F270S	Loligo forbesii northern European squid - (species)	Alloteuthis subulata (species)		opsin	Alloteuthis subulata (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision	Coding, Deletion N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000756	OPN1SW P03999	Physiology	4bp frameshift deletion in exon 1 of SWS1 that results in a premature stop codon N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D		opsin - (SWS1)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
opsin - (SWS1)	Color vision	Coding, SNP	Odontoceti tooth whales - (suborder)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000757	OPN1SW P03999	Physiology	E113G; disrupts opsin-chromophore binding	Cetacea whales - (order)	Odontoceti tooth whales - (suborder)		opsin - (SWS1)	Odontoceti tooth whales - (suborder)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (loss of violet-range sensitivity)	Coding, Deletion N	Sciurus carolinensis gray squirrel - (species) D	Intergeneric or Higher	Candidate Gene	Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006) Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.	GP00000758	OPN1SW P03999	Physiology	6bp deletion (residues 77-78) + 1bp frameshift deletion N	Sciurus carolinensis gray squirrel - (species)	Sciurus carolinensis gray squirrel - (species) D		opsin - (SWS1)	Sciurus carolinensis gray squirrel - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (loss of violet-range sensitivity)	Coding, Deletion	Sciurus carolinensis gray squirrel - (species) D	Intergeneric or Higher	Candidate Gene	Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006) Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.	GP00000759	OPN1SW P03999	Physiology	9bp deletion (residues 93-95)	Sciurus carolinensis gray squirrel - (species)	Sciurus carolinensis gray squirrel - (species) D		opsin - (SWS1)	Sciurus carolinensis gray squirrel - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	2 Mutations: Coding SNP	Melopsittacus undulatus budgerigar - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Radlwimmer FB; Blow NS (2000) Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change. 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000760	OPN1SW P03999	Physiology	2 mutations	Aves birds - (class)	Melopsittacus undulatus budgerigar - (species) D		opsin - (SWS1)	Melopsittacus undulatus budgerigar - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	2 Mutations: Coding SNP	Rhea americana greater rhea - (species) D	Intergeneric or Higher	Candidate Gene	Odeen A; Hastad O (2003) Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...] 2 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments. Wright MW; Bowmaker JK (2001) Retinal photoreceptors of paleognathous birds: the ostrich (Struthio camelus) and rhea (Rhea america[...]	GP00000761	OPN1SW P03999	Physiology	2 mutations	Aves birds - (class)	Rhea americana greater rhea - (species) D		opsin - (SWS1)	Rhea americana greater rhea - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	2 Mutations: Coding SNP	Larus (genus) D	Intergeneric or Higher	Candidate Gene	Odeen A; Hastad O (2003) Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...] 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000762	OPN1SW P03999	Physiology	2 mutations	Aves birds - (class)	Larus (genus) D		opsin - (SWS1)	Larus (genus)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	Coding, SNP	Trogon curucui (species) D	Intergeneric or Higher	Candidate Gene	Odeen A; Hastad O (2003) Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...] 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000763	OPN1SW P03999	Physiology	S86F	Aves birds - (class)	Trogon curucui (species) D		opsin - (SWS1)	Trogon curucui (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	Coding, SNP	Taeniopygia guttata zebra finch - (species)	Intergeneric or Higher	Candidate Gene	Yokoyama S; Radlwimmer FB; Blow NS (2000) Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change. 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00000764	OPN1SW P03999	Physiology	S90C	Passeriformes (order)	Taeniopygia guttata zebra finch - (species)		opsin - (SWS1)	Taeniopygia guttata zebra finch - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	3 Mutations: Coding SNP	Xenopus laevis African clawed frog - (species) D	Intergeneric or Higher	Candidate Gene	Takahashi Y; Yokoyama S (2005) Genetic basis of spectral tuning in the violet-sensitive visual pigment of African clawed frog, Xeno[...]	GP00000765	OPN1SW P03999	Physiology	3 mutations	Amniota amniotes - (no rank)	Xenopus laevis African clawed frog - (species) D		opsin - (SWS1)	Xenopus laevis African clawed frog - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, SNP	Macropodidae (family)	Intergeneric or Higher	Candidate Gene	Deeb SS; Wakefield MJ; Tada T ; et al. (2003) The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence[...] 1 Additional References Arrese CA; Oddy AY; Runham PB (2005) Cone topography and spectral sensitivity in two potentially trichromatic marsupials, the quokka (Set[...]	GP00000766	OPN1SW P03999	Physiology	F86Y	Metatheria marsupials - (no rank)	Macropodidae (family)		opsin - (SWS1)	Macropodidae (family)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, SNP	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Candidate Gene	Parry JW; Poopalasundaram S; Bowmaker JK ; et al. (2004) A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visu[...]	GP00000767	OPN1SW P03999	Physiology	F86V	Rodentia rodent - (order)	Cavia porcellus domestic guinea pig - (species)		opsin - (SWS1)	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, SNP	Sciurus carolinensis gray squirrel - (species)	Intergeneric or Higher	Candidate Gene	Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006) Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.	GP00000768	OPN1SW P03999	Physiology	F86Y	Rodentia rodent - (order)	Sciurus carolinensis gray squirrel - (species)		opsin - (SWS1)	Sciurus carolinensis gray squirrel - (species)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (UV-shift)	Coding, SNP	Aves birds - (class) D	Intergeneric or Higher	Candidate Gene	Carvalho LS; Cowing JA; Wilkie SE ; et al. (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments. 1 Additional References Carvalho LS; Cowing JA; Wilkie SE (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.	GP00001694	OPN1SW P03999	Physiology	V116L	Vertebrata vertebrates - (no rank)	Aves birds - (class) D		opsin - (SWS1)	Aves birds - (class)	Published - Accepted by Curator
opsin - (SWS1)	Color vision (violet-shift)	Coding, Deletion	Lepidopus fitchi (species) D	Intergeneric or Higher	Candidate Gene	Tada T; Altun A; Yokoyama S (2009) Evolutionary replacement of UV vision by violet vision in fish.	GP00001704	OPN1SW P03999	Physiology	deletion of Phe86 (3-bp deletion)	Actinopterygii ray-finned fishes - (superclass)	Lepidopus fitchi (species) D		opsin - (SWS1)	Lepidopus fitchi (species)	Published - Accepted by Curator
opsin - (SWS2)	Color vision (blue- and red-shifts)	2 Mutations: Coding SNP	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Candidate Gene	Marques DA; Taylor JS; Jones FC ; et al. (2017) Convergent evolution of SWS2 opsin facilitates adaptive radiation of threespine stickleback into dif[...]	GP00001679	opn1sw2 Q9W6A8	Physiology	2 mutations	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)		opsin - (SWS2)	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
opsin - (SWS2)	Color vision	3 Mutations: Coding SNP	Cottus gobio bullhead - (species) D	Intergeneric or Higher	Candidate Gene	Cowing JA; Poopalasundaram S; Wilkie SE ; et al. (2002) Spectral tuning and evolution of short wave-sensitive cone pigments in cottoid fish from Lake Baikal[...]	GP00001771	opn1sw2 Q9W6A8	Physiology	3 mutations	Cottidae sculpins - (family)	Cottus gobio bullhead - (species) D		opsin - (SWS2)	Cottus gobio bullhead - (species)	Published - Accepted by Curator
opsin - (SWS2B)	Color vision	Coding, SNP	Tramitichromis intermedius (species)	Interspecific	Candidate Gene	O'Quin KE; Schulte JE; Patel Z ; et al. (2012) Evolution of cichlid vision via trans-regulatory divergence.	GP00001440	opn1sw2 Q9W6A8	Physiology	Ala269Thr causing a 10nm Spectral Sensitivity Shift	Aulonocara baenschi Nkhomo-benga peacock cichlid - (species)	Tramitichromis intermedius (species)		opsin - (SWS2B)	Tramitichromis intermedius (species)	Published - Accepted by Curator
opsin - rhodopsin (LWRh)	Color vision (blue shift)	2 Mutations: Coding SNP	Limenitis archippus viceroy - (species)	Intergeneric or Higher	Candidate Gene	Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007) Adaptive evolution of color vision as seen through the eyes of butterflies.	GP00000769	LWRh E2DZP1	Physiology	2 mutations	Limenitis arthemis white admiral - (species)	Limenitis archippus viceroy - (species)		opsin - rhodopsin (LWRh)	Limenitis archippus viceroy - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWRh)	Color vision (blue shift)	2 Mutations: Coding SNP	Junonia buckeyes - (genus)	Intergeneric or Higher	Candidate Gene	Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007) Adaptive evolution of color vision as seen through the eyes of butterflies.	GP00000770	LWRh E2DZP1	Physiology	2 mutations	Nymphalidae brushfoots - (family)	Junonia buckeyes - (genus)		opsin - rhodopsin (LWRh)	Junonia buckeyes - (genus)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Deletion N	Balaenopteridae rorquals - (family) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000771	OPN1LW P04000	Physiology	22bp deletion including transciption start N	Cetacea whales - (order)	Balaenopteridae rorquals - (family) D		opsin - rhodopsin (LWS)	Balaenopteridae rorquals - (family)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Deletion N	Kogia breviceps pygmy sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000772	OPN1LW P04000	Physiology	44bp frameshift deletion 9 + possibly GT to CT splice site mutation N	Cetacea whales - (order)	Kogia breviceps pygmy sperm whale - (species) D		opsin - rhodopsin (LWS)	Kogia breviceps pygmy sperm whale - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Deletion N	Physeter catodon sperm whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000773	OPN1LW P04000	Physiology	1bp + 28bp frameshift deletions N	Cetacea whales - (order)	Physeter catodon sperm whale - (species) D		opsin - rhodopsin (LWS)	Physeter catodon sperm whale - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, Insertion N	Mesoplodon bidens Sowerby's beaked whale - (species) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000774	OPN1LW P04000	Physiology	4bp frameshift insertion in exon 2 of LWS N	Cetacea whales - (order)	Mesoplodon bidens Sowerby's beaked whale - (species) D		opsin - rhodopsin (LWS)	Mesoplodon bidens Sowerby's beaked whale - (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision	Coding, SNP	Balaenidae right whales - (family)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000775	OPN1LW P04000	Physiology	AG to GG splice site mutation	Cetacea whales - (order)	Balaenidae right whales - (family)		opsin - rhodopsin (LWS)	Balaenidae right whales - (family)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	Coding, SNP	Neochromis greenwoodi (species)	Interspecific	Candidate Gene	Terai Y; Seehausen O; Sasaki T ; et al. (2006) Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids.	GP00000776	OPN1LW P04000	Physiology	Candidate mutations are CS180A and/or I277C (human LWS/MWS numbering)	African cichlids (no rank)	Neochromis greenwoodi (species)		opsin - rhodopsin (LWS)	Neochromis greenwoodi (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue shift)	3 Mutations: Coding SNP	Pundamilia pundamilia (species)	Intraspecific	Candidate Gene	Seehausen O; Terai Y; Magalhaes IS ; et al. (2008) Speciation through sensory drive in cichlid fish.	GP00000777	OPN1LW P04000	Physiology	3 mutations	Pundamilia pundamilia (species)	Pundamilia pundamilia (species)		opsin - rhodopsin (LWS)	Pundamilia pundamilia (species)	Published - Accepted by Curator
opsin - rhodopsin (LWS)	Color vision (blue-shift)	Coding, SNP	Tursiops truncatus bottlenose dolphin - (species) D	Intergeneric or Higher	Candidate Gene	Fasick JI; Robsinson PR (1998) Mechanism of spectral tuning in the dolphin visual pigments.	GP00001703	OPN1LW P04000	Physiology	A292S	Mammalia mammals - (class)	Tursiops truncatus bottlenose dolphin - (species) D		opsin - rhodopsin (LWS)	Tursiops truncatus bottlenose dolphin - (species)	Published - Accepted by Curator
opsin - rhodopsin (MWS=duplicate of LWS)	Color vision (green-shift)	7 Mutations: Coding SNP	Catarrhini (parvorder)	Intergeneric or Higher	Candidate Gene	Asenjo AB; Rim J; Oprian DD (1994) Molecular determinants of human red/green color discrimination. 1 Additional References Hunt DM; Dulai KS; Cowing JA (1998) Molecular evolution of trichromacy in primates.	GP00000778	OPN1MW P04001	Physiology	7 mutations	Primates (order)	Catarrhini (parvorder)		opsin - rhodopsin (MWS=duplicate of LWS)	Catarrhini (parvorder)	Published - Accepted by Curator
opsin - rhodopsin (UVRh2)	Color vision (UV-shift)	2 Mutations: Coding SNP	Heliconius pachinus (species) Heliconius erato crimson-patched longwing - (species) Heliconius hortense (species) Heliconius sapho (species) Heliconius charithonia zebra longwing - (species) Heliconius melpomene postman butterfly - (species) Heliconius elevatus (species) Heliconius cydno (species)	Intergeneric or Higher	Candidate Gene	Briscoe AD; Bybee SM; Bernard GD ; et al. (2010) Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution[...] 1 Additional References Yuan F; Bernard GD; Le J (2010) Contrasting modes of evolution of the visual pigments in Heliconius butterflies.	GP00000779	UVRh2 E2DZL8	Physiology	2 mutations	Nymphalidae brushfoots - (family)	Heliconius pachinus (species) Heliconius erato crimson-patched longwing - (species) Heliconius hortense (species) Heliconius sapho (species) Heliconius charithonia zebra longwing - (species) Heliconius melpomene postman butterfly - (species) Heliconius elevatus (species) Heliconius cydno (species)		opsin - rhodopsin (UVRh2)	Heliconius pachinus (species) Heliconius erato crimson-patched longwing - (species) Heliconius hortense (species) Heliconius sapho (species) Heliconius charithonia zebra longwing - (species) Heliconius melpomene postman butterfly - (species) Heliconius elevatus (species) Heliconius cydno (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	2 Mutations: Coding SNP	undetermined Cottoidei 'Lake Baikal' (species)	Intergeneric or Higher	Candidate Gene	Hunt DM; Fitzgibbon J; Slobodyanyuk SJ ; et al. (1996) Spectral tuning and molecular evolution of rod visual pigments in the species flock of cottoid fish [...]	GP00000780	RHO P08100	Physiology	2 mutations	undetermined Cottoidei 'Lake Baikal' (species)	undetermined Cottoidei 'Lake Baikal' (species)		opsin - rhodopsin1 (RH1)	undetermined Cottoidei 'Lake Baikal' (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	Coding, SNP	Megaderma lyra Indian false vampire - (species) D	Intergeneric or Higher	Candidate Gene	Sugawara T; Imai H; Nikaido M ; et al. (2010) Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.	GP00000781	RHO P08100	Physiology	D83N	Chiroptera bats - (order)	Megaderma lyra Indian false vampire - (species) D		opsin - rhodopsin1 (RH1)	Megaderma lyra Indian false vampire - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	2 Mutations: Coding SNP	Sebastolobus altivelis (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T; Yamato T (2007 Mar-Apr) Modulation of the absorption maximum of rhodopsin by amino acids in the C-terminus. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000782	RHO P08100	Physiology	2 mutations	Teleostei teleost fishes - (infraclass)	Sebastolobus altivelis (species) D		opsin - rhodopsin1 (RH1)	Sebastolobus altivelis (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue shift)	Coding, SNP	Flaveria trinervia (species)	Intergeneric or Higher	Candidate Gene	Sugawara T; Imai H; Nikaido M ; et al. (2010) Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.	GP00000783	RHO P08100	Physiology	D83N	Vespertilionidae common bats - (family)	Flaveria trinervia (species)		opsin - rhodopsin1 (RH1)	Flaveria trinervia (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	Squamata squamates - (order) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Zhang H; Radlwimmer FB ; et al. (1999) Adaptive evolution of color vision of the Comoran coelacanth (Latimeria chalumnae). 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000784	RHO P08100	Physiology	D83N	Amniota amniotes - (no rank)	Squamata squamates - (order) D		opsin - rhodopsin1 (RH1)	Squamata squamates - (order)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	2 Mutations: Coding SNP	Orcinus orca killer whale - (species) D	Intergeneric or Higher	Candidate Gene	Dungan SZ; Kosyakov A; Chang BS (2016) Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functi[...] 1 Additional References Meredith RW; Gatesy J; Emerling CA (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000785	RHO P08100	Physiology	2 mutations	Bos taurus cattle - (species)	Orcinus orca killer whale - (species) D		opsin - rhodopsin1 (RH1)	Orcinus orca killer whale - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	African cichlids (no rank)	Intergeneric or Higher	Candidate Gene	Sugawara T; Terai Y; Imai H ; et al. (2005) Parallelism of amino acid changes at the RH1 affecting spectral sensitivity among deep-water cichlid[...] 1 Additional References Nagai H; Terai Y; Sugawara T (2011) Reverse evolution in RH1 for adaptation of cichlids to water depth in Lake Tanganyika.	GP00000786	RHO P08100	Physiology	A292S and reversals; many independent cases	African cichlids (no rank)	African cichlids (no rank)		opsin - rhodopsin1 (RH1)	African cichlids (no rank)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	3 Mutations: Coding SNP	Tursiops truncatus bottlenose dolphin - (species)	Intergeneric or Higher	Candidate Gene	Fasick JI; Robsinson PR (1998) Mechanism of spectral tuning in the dolphin visual pigments. 2 Additional References Sugawara T; Imai H; Nikaido M (2010) Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation. Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000787	RHO P08100	Physiology	3 mutations	Mammalia mammals - (class)	Tursiops truncatus bottlenose dolphin - (species)		opsin - rhodopsin1 (RH1)	Tursiops truncatus bottlenose dolphin - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	Elephantidae elephants - (family)	Intergeneric or Higher	Candidate Gene	Yokoyama S; Takenaka N; Agnew DW ; et al. (2005) Elephants and human color-blind deuteranopes have identical sets of visual pigments. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000788	RHO P08100	Physiology	D83N	Mammalia mammals - (class)	Elephantidae elephants - (family)		opsin - rhodopsin1 (RH1)	Elephantidae elephants - (family)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	Coding, SNP	Physeteridae sperm whales - (family)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000789	RHO P08100	Physiology	K195T	Cetacea whales - (order)	Physeteridae sperm whales - (family)		opsin - rhodopsin1 (RH1)	Physeteridae sperm whales - (family)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	2 Mutations: Coding SNP	Latimeria menadoensis Menado coelacanth - (species) D Latimeria chalumnae coelacanth - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T (2000) Adaptive evolution of the African and Indonesian coelacanths to deep-sea environments.	GP00000790	RHO P08100	Physiology	2 mutations	Teleostei teleost fishes - (infraclass)	Latimeria menadoensis Menado coelacanth - (species) D Latimeria chalumnae coelacanth - (species) D		opsin - rhodopsin1 (RH1)	Latimeria menadoensis Menado coelacanth - (species) Latimeria chalumnae coelacanth - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (blue-shift)	2 Mutations: Coding SNP	Cetacea whales - (order)	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Emerling CA ; et al. (2013) Rod monochromacy and the coevolution of cetacean retinal opsins.	GP00000791	RHO P08100	Physiology	2 mutations	Mammalia mammals - (class)	Cetacea whales - (order)		opsin - rhodopsin1 (RH1)	Cetacea whales - (order)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (red-shift)	Coding, SNP	Aristostomias scintillans shiny loosejaw - (species)	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T; Zhang H ; et al. (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...] 1 Additional References Yokoyama S (2012) Synthesis of Experimental Molecular Biology and Evolutionary Biology: An Example from the World of V[...]	GP00000792	RHO P08100	Physiology	D83N; M183F; M253L; F261Y; T289G; S292I; M317I - all together shift to red (see table S4 of Yokoyama PNAS) - individual changes not tested	Stomiidae barbeled dragonfishes - (family)	Aristostomias scintillans shiny loosejaw - (species)		opsin - rhodopsin1 (RH1)	Aristostomias scintillans shiny loosejaw - (species)	Published - Accepted by Curator
opsin - rhodopsin1 (RH1)	Color vision (green-shift)	Coding, SNP	Stomoxys calcitrans stable fly - (species)	Intraspecific	Candidate Gene	Olafson PU; Aksoy S; Attardo GM ; et al. (2021) The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduct[...]	GP00002535	RHO P08100	Physiology	Met>Leucine residue present at tuning site 17 which is extremely rare across insect LW opsins. In a survey of over 100 insect LW opsins it was detected only in the two corresponding Rh1 orthologs from M. domestica in addition to one in the distantly related species of thrips (Thysanoptera). The site is residue 17 based on the numbering system developed for butterflies which corresponds to residue 57 in Drosophila Rh1.	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species)		opsin - rhodopsin1 (RH1)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
opsin - rhodopsin1-A (RH1-A)	Color vision (blue shift)	3 Mutations: Coding SNP	Conger myriaster whitespotted conger - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Tada T; Zhang H ; et al. (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000793	RHO P08100	Physiology	3 mutations	Anguilla japonica Japanese eel - (species)	Conger myriaster whitespotted conger - (species) D		opsin - rhodopsin1-A (RH1-A)	Conger myriaster whitespotted conger - (species)	Published - Accepted by Curator
opsin - rhodopsin1-B (RH1-B)	Color vision (blue shift)	Coding, SNP	Anguilla japonica Japanese eel - (species) D	Intergeneric or Higher	Candidate Gene	Yokoyama S; Takenaka N; Agnew DW ; et al. (2005) Elephants and human color-blind deuteranopes have identical sets of visual pigments. 1 Additional References Yokoyama S; Tada T; Zhang H (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]	GP00000794	RHO P08100	Physiology	D83N	Conger myriaster whitespotted conger - (species)	Anguilla japonica Japanese eel - (species) D		opsin - rhodopsin1-B (RH1-B)	Anguilla japonica Japanese eel - (species)	Published - Accepted by Curator
Or22a	Olfaction	Coding, SNP	Drosophila sechellia (species) D Drosophila simulans (species) D Drosophila mauritiana (species) D	Interspecific	Candidate Gene	Auer TO; Khallaf MA; Silbering AF ; et al. (2020) Olfactory receptor and circuit evolution promote host specialization.	GP00002183	Or22a P81909	Physiology	Effect of the mutation tested in a Or22a construct which rescues the Or22a knock-down mutation in D. melanogaster.There are two other amino acid changes that may have an effect as well.	Drosophila melanogaster fruit fly - (species)	Drosophila sechellia (species) D Drosophila simulans (species) D Drosophila mauritiana (species) D		Or22a	Drosophila sechellia (species) Drosophila simulans (species) Drosophila mauritiana (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000799	OR7D4 Q8NG98	Physiology	P79L	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000800	OR7D4 Q8NG98	Physiology	R227G	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000801	OR7D4 Q8NG98	Physiology	T133M	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception.	GP00000802	OR7D4 Q8NG98	Physiology	S84N	Homo sapiens human - (species)	Homo sapiens human - (species)		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Keller A; Zhuang H; Chi Q ; et al. (2007) Genetic variation in a human odorant receptor alters odour perception. 1 Additional References Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000803	OR7D4 Q8NG98	Physiology	R227G	Homininae (subfamily)	Homo sapiens human - (species) D		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
OR7D4	Olfaction	Coding, SNP	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Zhuang H; Chien MS; Matsunami H (2009) Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.	GP00000804	OR7D4 Q8NG98	Physiology	M273T	Homininae (subfamily)	Homo sapiens human - (species) D		OR7D4	Homo sapiens human - (species)	Published - Accepted by Curator
ore	Taste (fruit)	Coding, SNP	Cucumis sativus cucumber - (species) D	Intraspecific	Candidate Gene	Qi J; Liu X; Shen D ; et al. (2013) A genomic variation map provides insights into the genetic basis of cucumber domestication and diver[...]	GP00001390	BCH1 E9JE14	Morphology; Physiology	p.Ala257Asp	Cucumis sativus cucumber - (species)	Cucumis sativus cucumber - (species) D		ore	Cucumis sativus cucumber - (species)	Published - Accepted by Curator
Os07g0603400	Grain size Grain quality	2 Mutations: Coding SNP N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Wang Y; Xiong G; Hu J ; et al. (2015) Copy number variation at the GL7 locus contributes to grain size diversity in rice.	GP00001542	Os07g0603400 A3BLY4	Morphology Physiology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Os07g0603400	Oryza sativa rice - (species)	Published - Accepted by Curator
OsC1	Coloration (loss of apiculus color)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Saitoh K; Onishi K; Mikami I ; et al. (2004) Allelic diversification at the C (OsC1) locus of wild and cultivated rice: nucleotide changes associ[...] 2 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Huang X; Kurata N; Wei X (2012) A map of rice genome variation reveals the origin of cultivated rice.	GP00000805	C Q76B79	Morphology	10bp deletion N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		OsC1	Oryza sativa rice - (species)	Published - Accepted by Curator
OsC1	Coloration (loss of apiculus color)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Saitoh K; Onishi K; Mikami I ; et al. (2004) Allelic diversification at the C (OsC1) locus of wild and cultivated rice: nucleotide changes associ[...] 2 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Huang X; Kurata N; Wei X (2012) A map of rice genome variation reveals the origin of cultivated rice.	GP00000806	C Q76B79	Morphology	2bp deletion N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		OsC1	Oryza sativa rice - (species)	Published - Accepted by Curator
OsCKX2=Gn1a	Grain yield	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Ashikari M; Sakakibara H; Lin S ; et al. (2005) Cytokinin oxidase regulates rice grain production.	GP00000807	CKX2 Q4ADV8	Morphology	11bp deletion causing premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		OsCKX2=Gn1a	Oryza sativa rice - (species)	Published - Accepted by Curator
OsPPKL1/qGL3	Grain size	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Zhang X; Wang J; Huang J ; et al. (2012) Rare allele of OsPPKL1 associated with grain length causes extra-large grain and a significant yield[...]	GP00000812	qLTG-3-1 B3IWI0	Morphology	Asp364Glu	Oryza sativa rice - (species)	Oryza sativa rice - (species)		OsPPKL1/qGL3	Oryza sativa rice - (species)	Published - Accepted by Curator
OVATE	Fruit shape	Coding, SNP N	Solanum lycopersicum tomato - (species)	Domesticated	Linkage Mapping	Liu J; Van Eck J; Cong B ; et al. (2002) A new class of regulatory genes underlying the cause of pear-shaped tomato fruit.	GP00000815	Q8GSM4	Morphology	V164* caused by G>T; which leads to a 75-aa truncation in the C terminus of the predicted protein N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species)		OVATE	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Overdrive	Hybrid incompatibility (male F1 sterility)	Coding, SNP	Drosophila pseudoobscura (species)	Intraspecific	Linkage Mapping	Phadnis N; Orr HA (2009) A single gene causes both male sterility and segregation distortion in Drosophila hybrids.	GP00000816	Ovd Q2LZF7	Physiology	6 candidate non-synonymous changes - the effect of single amino acid changes has not been tested	Drosophila pseudoobscura (species)	Drosophila pseudoobscura (species)		Overdrive	Drosophila pseudoobscura (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00000817	LPAR6 P43657	Morphology	at position 69 insertion of 4bp CATG - causes frameshift at codon 24 (PTC +29) N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001734	LPAR6 P43657	Morphology	2 deletions - one at position 172-175 delAACT and one at position 177 delG - cause frameshift at codon 58 (PTC +31) N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001735	LPAR6 P43657	Morphology	188A>T which causes D63V N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001736	LPAR6 P43657	Morphology	562A>T which causes I188F N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
P2RY5	Hair type (woolly)	Coding, SNP N	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Shimomura Y; Wajid M; Ishii Y ; et al. (2008) Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]	GP00001737	LPAR6 P43657	Morphology	565G>A which causes E189K N	Homo sapiens human - (species)	Homo sapiens human - (species) D		P2RY5	Homo sapiens human - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Ranson H; Jensen B; Vulule JM ; et al. (2000) Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]	GP00000818	para P35500	Physiology	L1014S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998) Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...] 1 Additional References Grigoraki L; Cowlishaw R; Nolan T (2021) CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution[...]	GP00000819	para P35500	Physiology	L1014F	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]	GP00000820	para P35500	Physiology	N1575Y	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		para (kdr)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00000821	para P35500	Physiology	2 mutations	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00000822	para P35500	Physiology	L925I	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Morin S; Williamson MS; Goodson SJ ; et al. (2002) Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00000823	para P35500	Physiology	M918V	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Smith TJ; Lee SH; Ingles PJ ; et al. (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...] 2 Additional References Miyazaki M; Ohyama K; Dunlap DY (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistanc[...]	GP00000824	para P35500	Physiology	L993F (=L1014F)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000825	para P35500	Physiology	C764R (=C785R)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Liu Z; Valles SM; Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...] 2 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Tan J; Liu Z; Tsai TD (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed chann[...]	GP00000826	para P35500	Physiology	E434K (=E435K)	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	He H; Chen AC; Davey RB ; et al. (1999) Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...] 1 Additional References Wang SY; Barile M; Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyre[...]	GP00000827	para P35500	Physiology	F1538I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes. 1 Additional References Ponce G; Sanchez IP; García SM (2016) First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico.	GP00000828	para P35500	Physiology	L1014F	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Chen L; Zhong D; Zhang D ; et al. (2010) Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.	GP00000829	para P35500	Physiology	L1014S	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005) Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...] 1 Additional References Franck P; Siegwart M; Olivares J (2012) Multiple origins of the sodium channel kdr mutations in codling moth populations.	GP00000830	para P35500	Physiology	L1014F	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D		para (kdr)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000831	para P35500	Physiology	(=M918T)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep) Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...] 1 Additional References Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000832	para P35500	Physiology	L150F (=L1014F)	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		para (kdr)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Zhao Y; Park Y; Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...] 3 Additional References Liu Z; Tan J; Valles SM (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium [...] Park Y; Taylor MF; Feyereisen R (1997) A valine421 to methionine mutation in IS6 of the hscp voltage-gated sodium channel associated with p[...] Lee SH; Soderlund DM (2001) The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethro[...]	GP00000834	para P35500	Physiology	V421M (=V410M)	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000835	para P35500	Physiology	V421M (=V410M)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000836	para P35500	Physiology	L1029H (= L1014H)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000837	para P35500	Physiology	V421A (=V410A)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]	GP00000838	para P35500	Physiology	V421G (=V410G)	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000839	para P35500	Physiology	L925I in species D	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Weston DP; Poynton HC; Wellborn GA ; et al. (2013) Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...] 1 Additional References Major KM; Weston DP; Lydy MJ (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00000840	para P35500	Physiology	M918L - ATG>CTG	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000841	para P35500	Physiology	2 mutations	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000842	para P35500	Physiology	L1014F	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Linkage Mapping	Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...] 3 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Smith TJ; Lee SH; Ingles PJ (1997) The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]	GP00000843	para P35500	Physiology	M918T	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Linkage Mapping	Martinez-Torres D; Foster SP; Field LM ; et al. (1999) A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]	GP00000844	para P35500	Physiology	L1014F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004) High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]	GP00000845	para P35500	Physiology	(=M918T)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	3 Mutations: Coding SNP	Pediculus humanus human louse - (species) D	Intraspecific	Candidate Gene	Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010) Determination of knockdown resistance allele frequencies in global human head louse populations usin[...] 3 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Lee Si Hyeock; Gao Jian-Rong; Yoon Kyong Sup (2003 ) Sodium channel mutations associated with knockdown resistance in the human head louse, Pediculus cap[...]	GP00000846	para P35500	Physiology	3 mutations	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D		para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Pediculus humanus human louse - (species) D	Intraspecific	Linkage Mapping	Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000 ) Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]	GP00000847	para P35500	Physiology	L932F	Pediculus humanus human louse - (species)	Pediculus humanus human louse - (species) D		para (kdr)	Pediculus humanus human louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Sonoda S; Igaki C; Tsumuki H (2008) Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00000848	para P35500	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Usherwood PN; Davies TG; Mellor IR ; et al. (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00000849	para P35500	Physiology	T929I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Triatoma infestans (species)	Intraspecific	Candidate Gene	Fabro J; Sterkel M; Capriotti N ; et al. (2012) Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]	GP00000850	para P35500	Physiology	L1014F	Triatoma infestans (species)	Triatoma infestans (species)		para (kdr)	Triatoma infestans (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000851	para P35500	Physiology	M918T	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000852	para P35500	Physiology	T929I	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Haddi K; Berger M; Bielza P ; et al. (2012) Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]	GP00000853	para P35500	Physiology	L1014F	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001689	para P35500	Physiology	L1014F; Haplotype H02	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001691	para P35500	Physiology	L1014S; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species)		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles vagus (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001692	para P35500	Physiology	L1014S	Anopheles vagus (species)	Anopheles vagus (species) D		para (kdr)	Anopheles vagus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001695	para P35500	Physiology	L1014S	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles paraliae (species)	Intraspecific	Candidate Gene	Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010) Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001696	para P35500	Physiology	L1014S	Anopheles paraliae (species)	Anopheles paraliae (species)		para (kdr)	Anopheles paraliae (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Wang ZM; Li CX ; et al. (2012) First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...] 1 Additional References Chang X; Zhong D; Lo E (2016) Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in An[...]	GP00001699	para P35500	Physiology	L1014F; Haplotype H04	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Cimex lectularius bed bug - (species) D	Intraspecific	Candidate Gene	Yoon KS; Kwon DH; Strycharz JP ; et al. (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] 4 Additional References Yoon KS; Kwon DH; Strycharz JP (2008) Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...] Seong KM; Lee DY; Yoon KS (2010) Establishment of quantitative sequencing and filter contact vial bioassay for monitoring pyrethroid [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Durand R; Cannet A; Berdjane Z (2012) Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France.	GP00001859	para P35500	Physiology	2 mutations	Cimex lectularius bed bug - (species)	Cimex lectularius bed bug - (species) D		para (kdr)	Cimex lectularius bed bug - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	González-Cabrera J; Davies TG; Field LM ; et al. (2013) An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor. 1 Additional References Hubert J; Nesvorna M; Kamler M (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00001860	para P35500	Physiology	L925V	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001861	para P35500	Physiology	M918L - found in samples from China and Europe	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)		para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Trialeurodes vaporariorum greenhouse whitefly - (species)	Intraspecific	Candidate Gene	Karatolos N; Gorman K; Williamson MS ; et al. (2012) Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...] 1 Additional References Kapantaidaki DE; Sadikoglou E; Tsakireli D (2018) Insecticide resistance in Trialeurodes vaporariorum populations and novel diagnostics for kdr mutati[...]	GP00001862	para P35500	Physiology	2 mutations	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species)		para (kdr)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species)	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001863	para P35500	Physiology	M918L - ATG>TTG - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).	Hyalella azteca (species)	Hyalella azteca (species)		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00001864	para P35500	Physiology	L925V	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 3 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...] Singh KS; Cordeiro EMG; Troczka BJ (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] Fontaine S; Caddoux L; Brazier C (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...]	GP00001865	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Panini M; Anaclerio M; Puggioni V ; et al. (2015) Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...] 1 Additional References Panini M; Dradi D; Marani G (2014) Detecting the presence of target-site resistance to neonicotinoids and pyrethroids in Italian popula[...]	GP00001866	para P35500	Physiology	M918L	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 2 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...] Brengues C; Hawkes NJ; Chandre F (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...]	GP00002444	para P35500	Physiology	V1016G	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Ishak IH; Jaal Z; Ranson H ; et al. (2015) Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002445	para P35500	Physiology	F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	3 Mutations: Coding SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Plernsub S; Saingamsook J; Yanola J ; et al. (2016) Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002446	para P35500	Physiology	3 mutations	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Kasai S; Ng LC; Lam-Phua SG ; et al. (2011) First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus. 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002447	para P35500	Physiology	F1534C	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002469	para P35500	Physiology	L1014S	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D		para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Phlebotomus argentipes (species) D	Intraspecific	Candidate Gene	Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021) Chemical control and insecticide resistance status of sand fly vectors worldwide.	GP00002470	para P35500	Physiology	L1014F	Phlebotomus argentipes (species)	Phlebotomus argentipes (species) D		para (kdr)	Phlebotomus argentipes (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002486	para P35500	Physiology	2 mutations	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D		para (kdr)	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Head DJ; McCaffery AR; Callaghan A (1998) Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]	GP00002487	para P35500	Physiology	2 mutations	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		para (kdr)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Haddi K; Tomé HVV; Du Y ; et al. (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...] 1 Additional References Fan Y; O'Grady P; Yoshimizu M (2020) Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes ae[...]	GP00002488	para P35500	Physiology	2 mutations	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Zhang L; Li T ; et al. (2012) Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following i[...]	GP00002489	para P35500	Physiology	3 nonsynonymous A(109)S L(982)F and W(1573)R) and 6 synonymous L(852) G(891) A(1241) D(1245) P(1249) and G(1733)) mutations were identified. The co-existence of all 9 mutations and their homozygousity were found to be important factors for high levels of resistance.	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Marshall Kate L; Moran Christopher; Chen Yizhou ; et al. (2012 ) Detection of kdr pyrethroid resistance in the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), u[...] 2 Additional References Wang ZJ; Liang CR; Shang ZY (2021) Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002490	para P35500	Physiology	L1014F	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Linkage Mapping	Nyoni BN; Gorman K; Mzilahowa T ; et al. (2011) Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation[...]	GP00002493	para P35500	Physiology	M918T - first report of the M918T mutation in the absence of L1014F in any arthropod species.	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D		para (kdr)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Liriomyza huidobrensis pea leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002494	para P35500	Physiology	2 mutations	Liriomyza huidobrensis pea leafminer - (species)	Liriomyza huidobrensis pea leafminer - (species) D		para (kdr)	Liriomyza huidobrensis pea leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Liriomyza sativae vegetable leafminer - (species) D	Intraspecific	Candidate Gene	Davies TG; Field LM; Usherwood PN ; et al. (2007) DDT, pyrethrins, pyrethroids and insect sodium channels.	GP00002495	para P35500	Physiology	L1014F	Liriomyza sativae vegetable leafminer - (species)	Liriomyza sativae vegetable leafminer - (species) D		para (kdr)	Liriomyza sativae vegetable leafminer - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002496	para P35500	Physiology	2 mutations	Thrips tabaci (species)	Thrips tabaci (species) D		para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Toda S; Morishita M (2009) Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]	GP00002497	para P35500	Physiology	T929I	Thrips tabaci (species)	Thrips tabaci (species) D		para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Carletto J; Martin T; Vanlerberghe-Masutti F ; et al. (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii.	GP00002498	para P35500	Physiology	M918L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D		para (kdr)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002499	para P35500	Physiology	M918L in species B	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Hyalella azteca (species) D	Intraspecific	Candidate Gene	Major KM; Weston DP; Lydy MJ ; et al. (2018) Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]	GP00002500	para P35500	Physiology	M918L in species C	Hyalella azteca (species)	Hyalella azteca (species) D		para (kdr)	Hyalella azteca (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Thrips tabaci (species) D	Intraspecific	Candidate Gene	Wu M; Gotoh H; Waters T ; et al. (2014) Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002501	para P35500	Physiology	2 mutations	Thrips tabaci (species)	Thrips tabaci (species) D		para (kdr)	Thrips tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Morgan JA; Corley SW; Jackson LA ; et al. (2009) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boop[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002502	para P35500	Physiology	L925I - Cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216 results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly Bemisia tabaci.	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Thrips palmi (species) D	Intraspecific	Candidate Gene	Bao Wen Xue; Sonoda Shoji (2012 ) Resistance to cypermethrin in melon thrips, Thrips palmi (Thysanoptera: Thripidae), is conferred by [...]	GP00002503	para P35500	Physiology	T929I	Thrips palmi (species)	Thrips palmi (species) D		para (kdr)	Thrips palmi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Rinkevich FD; Du Y; Dong K (2013) Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002504	para P35500	Physiology	T929I	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D		para (kdr)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitophilus zeamais maize weevil - (species) D	Intraspecific	Candidate Gene	Araújo RA; Williamson MS; Bass C ; et al. (2011) Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gat[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002505	para P35500	Physiology	T929I	Sitophilus zeamais maize weevil - (species)	Sitophilus zeamais maize weevil - (species) D		para (kdr)	Sitophilus zeamais maize weevil - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002506	para P35500	Physiology	T929V	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002507	para P35500	Physiology	T929C	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002508	para P35500	Physiology	T929I	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Forcioli D; Frey B; Frey JE (2002) High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002509	para P35500	Physiology	L1014F	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D		para (kdr)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Linkage Mapping	Endersby NM; Viduka K; Baxter SW ; et al. (2011) Widespread pyrethroid resistance in Australian diamondback moth, Plutella xylostella (L.), is relate[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002510	para P35500	Physiology	F1020S	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...] 2 Additional References Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...] Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002511	para P35500	Physiology	T929V	Bemisia tabaci (species)	Bemisia tabaci (species) D		para (kdr)	Bemisia tabaci (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002514	para P35500	Physiology	T929V	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002515	para P35500	Physiology	L1014F	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		para (kdr)	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Jonsson NN; Cutullè C; Corley SW ; et al. (2010) Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus microp[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Usherwood PN; Davies TG; Mellor IR (2007) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]	GP00002516	para P35500	Physiology	G72V = G933V - G toT non-synonymous mutation at nucleotide position 214 that results in a glycine to valine substitution (G72V)	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		para (kdr)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Helicoverpa zea corn earworm - (species) D	Intraspecific	Linkage Mapping	Hopkins BW; Pietrantonio PV (2010) The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002517	para P35500	Physiology	I951V = I936V	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D		para (kdr)	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Lepeophtheirus salmonis salmon louse - (species) D	Intraspecific	Candidate Gene	Fallang A; Denholm I; Horsberg TE ; et al. (2005) Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice Lepeophtheirus salm[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002518	para P35500	Physiology	Q945R in transmembrane segment IIS5	Lepeophtheirus salmonis salmon louse - (species)	Lepeophtheirus salmonis salmon louse - (species) D		para (kdr)	Lepeophtheirus salmonis salmon louse - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Brengues C; Hawkes NJ; Chandre F ; et al. (2003) Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002519	para P35500	Physiology	I104M = I1011M	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Saavedra-Rodriguez K; Urdaneta-Marquez L; Rajatileka S ; et al. (2007) A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin A[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002520	para P35500	Physiology	I1011V	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Enayati AA; Vatandoost H; Ladonni H ; et al. (2003) Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Ano[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Safi NHZ; Ahmadi AA; Nahzat S (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002521	para P35500	Physiology	L1014F - one point mutation difference involving a single A-T base change encoding a leucine to phenylalanine amino acid substitution in the pyrethroid-resistant strain.	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D		para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles stephensi Asian malaria mosquito - (species) D	Intraspecific	Candidate Gene	Safi NHZ; Ahmadi AA; Nahzat S ; et al. (2019) Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]	GP00002522	para P35500	Physiology	L1014S	Anopheles stephensi Asian malaria mosquito - (species)	Anopheles stephensi Asian malaria mosquito - (species) D		para (kdr)	Anopheles stephensi Asian malaria mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles subpictus (species) D	Intraspecific	Candidate Gene	Karunaratne SHPP; Hawkes Nicola J; Perera MDB ; et al. (2007 ) Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populatio[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002523	para P35500	Physiology	L1014F - TTA>TTT	Anopheles subpictus (species)	Anopheles subpictus (species) D		para (kdr)	Anopheles subpictus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Xu Q; Liu H; Zhang L ; et al. (2005) Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002524	para P35500	Physiology	L1014F	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		para (kdr)	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	D	Intraspecific	Candidate Gene	Rothwell JT; Morgan JA; James PJ ; et al. (2011) Mechanism of resistance to synthetic pyrethroids in buffalo flies in south-east Queensland. 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002525	para P35500	Physiology	L1014F		D		para (kdr)		Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Brassicogethes aeneus (species)	Intraspecific	Candidate Gene	Nauen Ralf; Zimmer Christoph T; Andrews Melanie ; et al. (2012 ) Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F.[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002526	para P35500	Physiology	L1014F - found in individuals from Denmark and Sweden	Brassicogethes aeneus (species)	Brassicogethes aeneus (species)		para (kdr)	Brassicogethes aeneus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Foster SP; Paul VL; Slater R ; et al. (2014) A mutation (L1014F) in the voltage-gated sodium channel of the grain aphid, Sitobion avenae, is asso[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002527	para P35500	Physiology	L1014F	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D		para (kdr)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Cerchiari B; Giannini S ; et al. (2005) Use of the RFLP-PCR diagnostic test for characterizing MACE and kdr insecticide resistance in the pe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002528	para P35500	Physiology	F979S (housefly numbering) located inside the linker segment IIS5-6	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species)	Intraspecific	Candidate Gene	Stump AD; Atieli FK; Vulule JM ; et al. (2004) Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles ga[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002529	para P35500	Physiology	L1014S	Anopheles arabiensis (species)	Anopheles arabiensis (species)		para (kdr)	Anopheles arabiensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Dykes CL; Das MK ; et al. (2010) Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in [...]	GP00002530	para P35500	Physiology	L1014S	Anopheles culicifacies (species)	Anopheles culicifacies (species) D		para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles culicifacies (species) D	Intraspecific	Candidate Gene	Singh OP; Bali P; Hemingway J ; et al. (2009) PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato.	GP00002531	para P35500	Physiology	L1014F	Anopheles culicifacies (species)	Anopheles culicifacies (species) D		para (kdr)	Anopheles culicifacies (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Lüleyap HU; Alptekin D; Kasap H ; et al. (2002) Detection of knockdown resistance mutations in Anopheles sacharovi (Diptera: Culicidae) and genetic [...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...]	GP00002532	para P35500	Physiology	L1014S	Anopheles sacharovi (species)	Anopheles sacharovi (species)		para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sacharovi (species)	Intraspecific	Candidate Gene	Yavaşoglu Sİ; Ülger C; Şimşek FM (2021) The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002533	para P35500	Physiology	L1014F	Anopheles sacharovi (species)	Anopheles sacharovi (species)		para (kdr)	Anopheles sacharovi (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Pitzer JB; Kaufman PE (2011) Identification of a mutation associated with permethrin resistance in the para-type sodium channel o[...] 2 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Olafson PU; Kaufman PE; Duvallet G (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002534	para P35500	Physiology	L1014H	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D		para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Kang S; Jung J; Lee S ; et al. (2012) The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles si[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002536	para P35500	Physiology	L1014C	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002537	para P35500	Physiology	L1014C in Nicaragua and Costa Rica individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D		para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Lol JC; Castellanos ME; Liebman KA ; et al. (2013) Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002538	para P35500	Physiology	L1014F in Mexico individuals	Anopheles albimanus (species)	Anopheles albimanus (species) D		para (kdr)	Anopheles albimanus (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Wang ZM; Li CX; Xing D ; et al. (2012) Detection and widespread distribution of sodium channel alleles characteristic of insecticide resist[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002539	para P35500	Physiology	L1014C	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D		para (kdr)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles sinensis (species) D	Intraspecific	Candidate Gene	Tan WL; Li CX; Wang ZM ; et al. (2012) First detection of multiple knockdown resistance (kdr)-like mutations in voltage-gated sodium channe[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002540	para P35500	Physiology	L1014W	Anopheles sinensis (species)	Anopheles sinensis (species) D		para (kdr)	Anopheles sinensis (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Pridgeon Julia W; Appel Arthur G; Moar William J ; et al. (2002 ) Variability of resistance mechanisms in pyrethroid resistant German cockroaches (Dictyoptera: Blatte[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002541	para P35500	Physiology	F999S = F1020S - T to C at nt 2996 resulting in a phenylalanine999 to serine999 amino acid change	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		para (kdr)	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Clark J Marshall; Lee Si Hyeock (2010 ) Cloning of a sodium channel gene and identification of mutations putatively associated with fenpropa[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002542	para P35500	Physiology	L1024V	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002543	para P35500	Physiology	A1549V = A1410V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002544	para P35500	Physiology	A1648V = A1494V	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kawada H; Higa Y; Komagata O ; et al. (2009) Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroi[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002545	para P35500	Physiology	F1269C = F1534C	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus cinnabarinus carmine spider mite - (species) D	Intraspecific	Candidate Gene	Feng YN; Zhao S; Sun W ; et al. (2011) The sodium channel gene in Tetranychus cinnabarinus (Boisduval): identification and expression analy[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002546	para P35500	Physiology	F1538I	Tetranychus cinnabarinus carmine spider mite - (species)	Tetranychus cinnabarinus carmine spider mite - (species) D		para (kdr)	Tetranychus cinnabarinus carmine spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Tsagkarakou A; Van Leeuwen T; Khajehali J ; et al. (2009) Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-s[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002547	para P35500	Physiology	F1538I	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		para (kdr)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997) Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002548	para P35500	Physiology	M1524I	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		para (kdr)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Hubert J; Nesvorna M; Kamler M ; et al. (2014) Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]	GP00002549	para P35500	Physiology	F975L	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...] 1 Additional References Dong K; Du Y; Rinkevich F (2014) Molecular biology of insect sodium channels and pyrethroid resistance.	GP00002550	para P35500	Physiology	F1528L+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Varroa destructor honeybee mite - (species) D	Intraspecific	Candidate Gene	Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002 ) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]	GP00002551	para P35500	Physiology	F758L+L826P+I982V+M1055I = F1528L+L1596P+I1752V+M1823I	Varroa destructor honeybee mite - (species)	Varroa destructor honeybee mite - (species) D		para (kdr)	Varroa destructor honeybee mite - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Stomoxys calcitrans stable fly - (species) D	Intraspecific	Candidate Gene	Olafson PU; Kaufman PE; Duvallet G ; et al. (2019) Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]	GP00002613	para P35500	Physiology	L1014F	Stomoxys calcitrans stable fly - (species)	Stomoxys calcitrans stable fly - (species) D		para (kdr)	Stomoxys calcitrans stable fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002614	para P35500	Physiology	M918I ATG>ATT	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...] 1 Additional References Vais H; Williamson MS; Devonshire AL (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.	GP00002615	para P35500	Physiology	M918I ATG>ATA	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Kushwah RBS; Kaur T; Dykes CL ; et al. (2020) A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegy[...]	GP00002625	para P35500	Physiology	F1534L - Phe (TTC) > Leu (CTC)	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		para (kdr)	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002629	para P35500	Physiology	F1845Y	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Wang XL; Su W; Zhang JH ; et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002630	para P35500	Physiology	V1848I	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		para (kdr)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002631	para P35500	Physiology	V1848I	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Mavridis K; Riga M ; et al. (2017) Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...] 1 Additional References Samantsidis GR; O'Reilly AO; Douris V (2019) Functional validation of target-site resistance mutations against sodium channel blocker insecticide[...]	GP00002632	para P35500	Physiology	F1845Y	Tuta absoluta (species)	Tuta absoluta (species) D		para (kdr)	Tuta absoluta (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002644	para P35500	Physiology	super-kdr+D600N - super-kdr+D600N confers higher levels of resistance to seven pyrethroids relative to super-kdr.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Sun H; Kasai S; Scott JG (2017) Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]	GP00002645	para P35500	Physiology	kdr+T929I - addition of T929I to the kdr mutation (L1014F) increased resistance to all pyrethroids (except etofenprox) and enhanced resistance by ~1000-fold to acrinathrin and flumethrin.	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		para (kdr)	Musca domestica house fly - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002646	para P35500	Physiology	F1534S	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Wu Y; Liu Q; Qi Y ; et al. (2021) Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]	GP00002647	para P35500	Physiology	I1532T	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		para (kdr)	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
para (kdr)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Fontaine S; Caddoux L; Brazier C ; et al. (2011) Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...] 1 Additional References Bass C; Puinean AM; Zimmer CT (2014) The evolution of insecticide resistance in the peach potato aphid, Myzus persicae.	GP00002649	para P35500	Physiology	L932F	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		para (kdr)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
Pax3	Coloration (white-spotting ; leucism)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Hauswirth R; Haase B; Blatter M ; et al. (2012) Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses.	GP00002252	PAX3 P23760	Morphology	c.209G>A p.C70Y	Equus caballus horse - (species)	Equus caballus horse - (species) D		Pax3	Equus caballus horse - (species)	Published - Accepted by Curator
Pax3	Coloration (white-spotting ; leucism)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Hauswirth R; Jude R; Haase B ; et al. (2013) Novel variants in the KIT and PAX3 genes in horses with white-spotted coat colour phenotypes.	GP00002253	PAX3 P23760	Morphology	c.95C>G p.Pro32Arg	Equus caballus horse - (species)	Equus caballus horse - (species) D		Pax3	Equus caballus horse - (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001321	peel-1 G5EGC6	Physiology	1bp deletion creating a frameshift starting at amino acid position 43. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
peel-1	Hybrid incompatibility	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Seidel HS; Ailion M; Li J ; et al. (2011) A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...] 1 Additional References Seidel HS; Rockman MV; Kruglyak L (2008) Widespread genetic incompatibility in C. elegans maintained by balancing selection.	GP00001322	peel-1 G5EGC6	Physiology	G>T - glycine to stop codon at position 57. Total length of wild-type protein is 174 amino acids. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		peel-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
PEPT1	Anti-freezing	Coding, Unknown	Chionodraco hamatus Antarctic icefish - (species)	Intergeneric or Higher	Candidate Gene	Rizzello A; Romano A; Kottra G ; et al. (2013) Protein cold adaptation strategy via a unique seven-amino acid domain in the icefish (Chionodraco ha[...]	GP00000858	slc15a1 Q804I3	Physiology	C-terminal (cytosolic) de novo VDMSRKS domain conferring cold resistance	Teleostei teleost fishes - (infraclass)	Chionodraco hamatus Antarctic icefish - (species)		PEPT1	Chionodraco hamatus Antarctic icefish - (species)	Published - Accepted by Curator
PER36	Mucilage (seeds)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Macquet A; Ralet MC; Loudet O ; et al. (2007) A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...] 1 Additional References Kunieda T; Shimada T; Kondo M (2013) Spatiotemporal secretion of PEROXIDASE36 is required for seed coat mucilage extrusion in Arabidopsis[...]	GP00001273	PER36 Q9SD46	Physiology	Tyrosine @position 262bp to a stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		PER36	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Period (per)	Courtship song	Coding, SNP	Drosophila simulans (species)	Interspecific	Linkage Mapping	Wheeler DA; Kyriacou CP; Greenacre ML ; et al. (1991) Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaste[...] 3 Additional References Kyriacou CP; Hall JC (1986) Interspecific genetic control of courtship song production and reception in Drosophila. Kyriacou CP; Green EW; Piffer A (2017) Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detec[...] Stern DL (2014) Reported Drosophila courtship song rhythms are artifacts of data analysis.	GP00000860	per P07663	Behavior	A121T and/or K125R and/or E165D and /or V224A	Drosophila melanogaster fruit fly - (species)	Drosophila simulans (species)		Period (per)	Drosophila simulans (species)	Published - Accepted by Curator
Period (per)	Locomotor activity (temperature sensitivity)	Coding, Indel	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Sawyer LA; Hennessy JM; Peixoto AA ; et al. (1997) Natural variation in a Drosophila clock gene and temperature compensation.	GP00002002	per P07663	Behavior	repeat (Thr-Gly) either 17 times or 20 times within the protein coding sequence	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		Period (per)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
PG	Fruit ripening	Coding, Deletion N	Capsicum annuum (species) D	Domesticated	Candidate Gene	Kim S; Park M; Yeom SI ; et al. (2014) Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]	GP00001448	PG B9VRK6	Physiology	a partial deletion of about 90aa in the C-terminal region N	Solanum lycopersicum tomato - (species)	Capsicum annuum (species) D		PG	Capsicum annuum (species)	Published - Accepted by Curator
PG	Fruit ripening	Coding, SNP N	Capsicum chinense (species) D	Domesticated	Candidate Gene	Kim S; Park M; Yeom SI ; et al. (2014) Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]	GP00001449	PG B9VRK6	Physiology	a point mutation in the 3' splice acceptor site of intron VIII generates a premature stop codon N	Solanum lycopersicum tomato - (species)	Capsicum chinense (species) D		PG	Capsicum chinense (species)	Published - Accepted by Curator
PH4/GmMYB-G20-1	Coloration (flowers)	Coding, SNP N	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Takahashi R; Benitez ER; Oyoo ME ; et al. (2011 Jul-Aug) Nonsense mutation of an MYB transcription factor is associated with purple-blue flower color in soyb[...]	GP00000862	PH4 Q2TCH0	Morphology	Substitution creating premature Stop (codon 158) N	Glycine max soybean - (species)	Glycine max soybean - (species)		PH4/GmMYB-G20-1	Glycine max soybean - (species)	Published - Accepted by Curator
PHO84	Xenobiotic resistance	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Perlstein EO; Ruderfer DM; Roberts DC ; et al. (2007) Genetic basis of individual differences in the response to small-molecule drugs in yeast.	GP00000865	PHO84 P25297	Physiology	L259P	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		PHO84	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Phosphate transporter PHO1	Root growth (allometry of lateral roots)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Rosas U; Cibrian-Jaramillo A; Ristova D ; et al. (2013) Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling [...]	GP00001284	PHO1 Q8S403	Morphology	histidine to tyrosine @position 8388425 in chromosome III	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Phosphate transporter PHO1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	Coding, SNP	Alloteropsis (genus)	Interspecific	Candidate Gene	Christin PA; Edwards EJ; Besnard G ; et al. (2012) Adaptive evolution of C(4) photosynthesis through recurrent lateral gene transfer.	GP00000866	PPCA P30694	Physiology	Haplotype of several candidate a.a. ; lateral gene transfer between convergent C4 species	Alloteropsis (genus)	Alloteropsis (genus)		phosphoenolpyruvate carboxylase (PEPC)	Alloteropsis (genus)	Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)	C3-C4 photosynthesis (enzymatic properties)	2 Mutations: Coding SNP N	Flaveria trinervia (species)	Interspecific	Candidate Gene	Bläsing OE; Westhoff P; Svensson P (2000) Evolution of C4 phosphoenolpyruvate carboxylase in Flaveria, a conserved serine residue in the carbo[...] 1 Additional References Engelmann S; Bläsing OE; Gowik U (2003) Molecular evolution of C4 phosphoenolpyruvate carboxylase in the genus Flaveria--a gradual increase [...]	GP00000867	PPCA P30694	Physiology	2 mutations	Flaveria pringlei (species)	Flaveria trinervia (species)		phosphoenolpyruvate carboxylase (PEPC)	Flaveria trinervia (species)	Published - Accepted by Curator
phytochrome A (PHYA)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Maloof JN; Borevitz JO; Dabi T ; et al. (2001) Natural variation in light sensitivity of Arabidopsis.	GP00000870	PHYA P14712	Physiology	M548T	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome A (PHYA)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome A (PHYA)	Light sensitivity High-altitude adaptation	Coding, Insertion N	Glycine max soybean - (species) D	Domesticated	Candidate Gene	Liu B; Kanazawa A; Matsumura H ; et al. (2008) Genetic redundancy in soybean photoresponses associated with duplication of the phytochrome A gene. 1 Additional References Kanazawa A; Liu B; Kong F (2009) Adaptive evolution involving gene duplication and insertion of a novel Ty1/copia-like retrotransposo[...]	GP00002104	PHYA P14712	Physiology Physiology	insertion of a retrotransposon in exon 1 - The transposable element is SORE-1 = a novel Ty1/copia-like retrotransposon in soybean N	Glycine max soybean - (species)	Glycine max soybean - (species) D		phytochrome A (PHYA)	Glycine max soybean - (species)	Published - Accepted by Curator
phytochrome A-associated F-box protein	Circadian rhythm (phase)	Coding, Deletion	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Müller NA; Wijnen CL; Srinivasan A ; et al. (2016) Domestication selected for deceleration of the circadian clock in cultivated tomato.	GP00001287	101247753 K4CV85	Physiology	3bp deletion in CDS causing a 'K (lysine) loss in the highly conserved C terminus of EID1	Solanum pimpinellifolium (species)	Solanum lycopersicum tomato - (species) D		phytochrome A-associated F-box protein	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
phytochrome B (PHYB)	Light sensitivity	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Filiault DL; Wessinger CA; Dinneny JR ; et al. (2008) Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.	GP00000871	PHYB P14713	Physiology	I143L	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome B (PHYB)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome B (PHYB)	Light sensitivity	Coding, Deletion	Sorghum bicolor sorghum - (species) D	Domesticated	Linkage Mapping	Childs KL; Miller FR; Cordonnier-Pratt MM ; et al. (1997) The sorghum photoperiod sensitivity gene, Ma3, encodes a phytochrome B.	GP00000872	PHYB P14713	Physiology	1bp deletion 30bp upstream of the stop codon	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species) D		phytochrome B (PHYB)	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
phytochrome C (PHYC)	Light sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006) The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]	GP00000873	PHYC P14714	Physiology	K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		phytochrome C (PHYC)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytochrome D (PHYD)	Leaf morphology (increased petiole length) Cotyledon morphology (reduced cotyledon area) Coloration (anthocyanin accumulation in seedling stems) Plant size (diminished effect of end-of-day pulse of far red light on hypocotyl elongation) Plant architecture (decrease in number of rosette leaves at onset of flowering)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Aukerman MJ; Hirschfeld M; Wester L ; et al. (1997) A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome [...]	GP00000874	PHYD P42497	Morphology Morphology Morphology Physiology Morphology	14bp deletion causing premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		phytochrome D (PHYD)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
phytoene synthase	Carotenoid content (fruit)	Coding, Insertion N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Fray RG; Grierson D (1993) Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequen[...] 1 Additional References Gilbert C; Feschotte C (2018) Horizontal acquisition of transposable elements and viral sequences: patterns and consequences.	GP00001718	PSY1 P49085	Physiology	insertion of a Rider transposable element within the coding region N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D		phytoene synthase	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
phytoene synthase	Carotenoid content (fruit)	Coding, Indel N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Fray RG; Grierson D (1993) Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequen[...] 1 Additional References Gilbert C; Feschotte C (2018) Horizontal acquisition of transposable elements and viral sequences: patterns and consequences.	GP00001719	PSY1 P49085	Physiology	r y cDNA was found to be mutated at its 3' end, lacking the last 237 bases of PSY1 coding sequence and containing 185 nucleotides of an unrelated sequence in its place N	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D		phytoene synthase	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Pi-ta	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Bryan GT; Wu KS; Farrall L ; et al. (2000) tA single amino acid difference distinguishes resistant and susceptible alleles of the rice blast re[...] 2 Additional References He Z; Zhai W; Wen H (2011) Two evolutionary histories in the genome of rice: the roles of domestication genes. Xu X; Liu X; Ge S (2011) Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically [...]	GP00000876	Pi-ta C9E6G5	Physiology	Ala918Ser	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi-ta	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi2 (Nbs4-Pi2)	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Zhou B; Qu S; Liu G ; et al. (2006) The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance [...]	GP00000877	PI2 M1EC06	Physiology	eight amino acid changes - exact causing change(s) unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi2 (Nbs4-Pi2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi36	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Liu X; Lin F; Wang L ; et al. (2007) The in silico map-based cloning of Pi36, a rice coiled-coil nucleotide-binding site leucine-rich rep[...]	GP00000878	Pi36 D5J6W0	Physiology	Asp590Ser	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi36	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi37	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Lin F; Chen S; Que Z ; et al. (2007) The blast resistance gene Pi37 encodes a nucleotide binding site leucine-rich repeat protein and is [...]	GP00000879	Pi37 Q06AJ9	Physiology	V239A and I247M are the only amino acid substitutions found in all tested resistant strains- the effect of each individual amino acid change has not been tested	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi37	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi5-1 + Pi5-2 cluster	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Lee SK; Song MY; Seo YS ; et al. (2009) Rice Pi5-mediated resistance to Magnaporthe oryzae requires the presence of two coiled-coil-nucleoti[...]	GP00000880	Pi5-1 C3SBK3	Physiology	In genetic transformation experiments of a susceptible rice cultivar neither the Pi5-1 nor the Pi5-2 gene was found to confer resistance to M. oryzae. In contrast transgenic rice plants expressing both of these genes (generated by crossing transgenic lines carrying each gene individually) conferred Pi5-mediated resistance to M. oryzae	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi5-1 + Pi5-2 cluster	Oryza sativa rice - (species)	Published - Accepted by Curator
Pi9 (= Nbs2-Pi9)	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Qu S; Liu G; Zhou B ; et al. (2006) The broad-spectrum blast resistance gene Pi9 encodes a nucleotide-binding site-leucine-rich repeat p[...]	GP00000881	Pi9 Q1WGB0	Physiology	Coding variation; necessary for resistance in completementation assay	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pi9 (= Nbs2-Pi9)	Oryza sativa rice - (species)	Published - Accepted by Curator
Pid3	Pathogen resistance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Chen J; Shi Y; Liu W ; et al. (2011) A Pid3 allele from rice cultivar Gumei2 confers resistance to Magnaporthe oryzae.	GP00000883	Pid3 C0LMX9	Physiology	1bp deletion resulting in truncated protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Pid3	Oryza sativa rice - (species)	Published - Accepted by Curator
Pikm1-TS + Pikm2-TS cluster	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Ashikawa I; Hayashi N; Yamane H ; et al. (2008) Two adjacent nucleotide-binding site-leucine-rich repeat class genes are required to confer Pikm-spe[...] 1 Additional References Hua L; Wu J; Chen C (2012) The isolation of Pi1, an allele at the Pik locus which confers broad spectrum resistance to rice bla[...]	GP00000884	PIKM1-TS B5UBC1	Physiology	Coding variation in both genes; with alleles of both genes necessary for resistance in completementation assays	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Pikm1-TS + Pikm2-TS cluster	Oryza sativa rice - (species)	Published - Accepted by Curator
Piz-t	Pathogen resistance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Zhou B; Qu S; Liu G ; et al. (2006) The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance [...]	GP00000895	Piz-t Q0H213	Physiology	Coding variation in the LRR domain	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Piz-t	Oryza sativa rice - (species)	Published - Accepted by Curator
Pl6	Pathogen resistance	Coding, Unknown	Helianthus annuus common sunflower - (species) D	Domesticated	Linkage Mapping	Franchel J; Bouzidi MF; Bronner G ; et al. (2013) Positional cloning of a candidate gene for resistance to the sunflower downy mildew, Plasmopara hals[...]	GP00000896	F8R6K4	Physiology	unknown ; cluster of several R-protein coding genes; of which only one is expressed	Helianthus annuus common sunflower - (species)	Helianthus annuus common sunflower - (species) D		Pl6	Helianthus annuus common sunflower - (species)	Published - Accepted by Curator
Plasma membrane ATPase 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001300	PMA1 P05030	Physiology	A>T (Phe > Ile) @ position 1831	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Plasma membrane ATPase 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Plasma membrane ATPase 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001301	PMA1 P05030	Physiology	T>G (Thr > Pro) @ position 2197	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Plasma membrane ATPase 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Plasma membrane ATPase 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001302	PMA1 P05030	Physiology	G>T (Ala > Asp) @ position 2204	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Plasma membrane ATPase 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
plep-1	Male-male copulatory behavior	Coding, SNP	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Noble LM; Chang AS; McNelis D ; et al. (2015) Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.	GP00000897	plep-1 A0A0K3AR66	Behavior	V278D	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		plep-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
plg-1	Copulatory plug	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Palopoli MF; Rockman MV; TinMaung A ; et al. (2008) Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.	GP00000898		Physiology	insertion of transposable element in an exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		plg-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
Pm3	Pathogen resistance	Coding, SNP	Triticum aestivum bread wheat - (species)	Intraspecific	Linkage Mapping	Yahiaoui N; Kaur N; Keller B (2009) Independent evolution of functional Pm3 resistance genes in wild tetraploid wheat and domesticated b[...] 1 Additional References Yahiaoui N; Brunner S; Keller B (2006) Rapid generation of new powdery mildew resistance genes after wheat domestication.	GP00000899	PM3 C1K3M2	Physiology	Various substitution haplotypes - exact causing amino acid change(s) unknown - in hexaploid bread wheat one amino acid change in a solvent‐exposed residue of LRR27 (E1334 to V1334) was sufficient to convert the susceptible Pm3CS into a functional resistance allele (Yahiaoui et al., 2006).	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Pm3	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 2 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...] Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000900	PMA1 P05030	Physiology	Leu363Trp	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 2 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...] Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000901	PMA1 P05030	Physiology	Ser234Cys	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000902	PMA1 P05030	Physiology	Val127Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000903	PMA1 P05030	Physiology	Val157Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000904	PMA1 P05030	Physiology	Gly294Val	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000905	PMA1 P05030	Physiology	Gly337Ser	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000906	PMA1 P05030	Physiology	Met530Ile	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000907	PMA1 P05030	Physiology	Pro535Thr	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000908	PMA1 P05030	Physiology	Iso564Thr	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000909	PMA1 P05030	Physiology	Ala732Val	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMA1	Salt tolerance (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000910	PMA1 P05030	Physiology	Trp750Cys	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMA1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
PMEI6	Mucilage (seeds)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014) Local evolution of seed flotation in Arabidopsis. 1 Additional References Saez-Aguayo S; Ralet MC; Berger A (2013) PECTIN METHYLESTERASE INHIBITOR6 promotes Arabidopsis mucilage release by limiting methylesterificat[...]	GP00001272	AXX17_At2g45450 A0A178VVA1	Physiology	frameshift mutation due to a 1-bp insertion 581 bp after the ATG codon that changed amino acids 194 to 205 followed by the introduction of a stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		PMEI6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
PMEL17	Coloration (feathers)	Coding, Deletion	Gallus gallus chicken - (species) D	Domesticated	Candidate Gene	Kerje S; Sharma P; Gunnarsson U ; et al. (2004) The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion p[...]	GP00000911	PMEL Q98917	Morphology	deletion of amino acids 731-735	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		PMEL17	Gallus gallus chicken - (species)	Published - Accepted by Curator
PMEL17	Coloration (feathers)	Coding, Deletion	Gallus gallus chicken - (species) D	Domesticated	Candidate Gene	Kerje S; Sharma P; Gunnarsson U ; et al. (2004) The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion p[...]	GP00000912	PMEL Q98917	Morphology	deletion of amino acids 280-284	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		PMEL17	Gallus gallus chicken - (species)	Published - Accepted by Curator
PMEL17	Coloration (feathers)	Coding, Insertion	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Kerje S; Sharma P; Gunnarsson U ; et al. (2004) The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion p[...]	GP00000913	PMEL Q98917	Morphology	insertion of amino acid 723-725 due to a 9bp-insert in exon 10	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		PMEL17	Gallus gallus chicken - (species)	Published - Accepted by Curator
PMEL17	Coloration (coat)	Coding, Deletion	Bos grunniens domestic yak - (species) D	Domesticated	Candidate Gene	Zhang MQ; Xu X; Luo SJ (2014) The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens).	GP00001365	PMEL P40967	Morphology	c.50_52del p.Leu18del in signal peptide	Bos grunniens domestic yak - (species)	Bos grunniens domestic yak - (species) D		PMEL17	Bos grunniens domestic yak - (species)	Published - Accepted by Curator
PMEL17	Coloration (coat)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Gutiérrez-Gil B; Wiener P; Williams JL (2007) Genetic effects on coat colour in cattle: dilution of eumelanin and phaeomelanin pigments in an F2-B[...]	GP00002027	PMEL Q06154	Morphology	g.57669926G>A c.64G>A p.Gly22Arg	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		PMEL17	Bos taurus cattle - (species)	Published - Accepted by Curator
PMEL17	Coloration (coat)	Coding, Deletion	Bos taurus cattle - (species) D Bos grunniens domestic yak - (species) D	Domesticated	Candidate Gene	Jolly RD; Wills JL; Kenny JE ; et al. (2008) Coat-colour dilution and hypotrichosis in Hereford crossbred calves.	GP00002028	PMEL Q06154	Morphology	3bp deletion - g.57669913_57669915delTTC - c.50_52delTTC - p.Leu19del	Bos taurus cattle - (species)	Bos taurus cattle - (species) D Bos grunniens domestic yak - (species) D		PMEL17	Bos taurus cattle - (species) Bos grunniens domestic yak - (species)	Published - Accepted by Curator
PMEL17	Coloration (coat)	Coding, Insertion	Mus musculus house mouse - (species) D	Domesticated	Linkage Mapping	Kwon BS; Halaban R; Ponnazhagan S ; et al. (1995) Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pme[...]	GP00002101	Pmel Q60696	Morphology	single nucleotide (A) insertion in the putative cytoplasmic tail of the si/si Pmel 17 cDNA clone. This insertion is predicted to alter the last 24 amino acids at the C-terminus. Also predicted is the extension of the Pmel 17 protein by 12 residues because a new termination signal is created downstream from the wild-type reading frame. The silver pmel 17 protein has a major defect at the carboxyl terminus.	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D		PMEL17	Mus musculus house mouse - (species)	Published - Accepted by Curator
PMEL17	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Association Mapping	Brunberg E; Andersson L; Cothran G ; et al. (2006) A missense mutation in PMEL17 is associated with the Silver coat color in the horse. 4 Additional References Reissmann M; Bierwolf J; Brockmann GA (2007) Two SNPs in the SILV gene are associated with silver coat colour in ponies. Bellone RR (2010) Pleiotropic effects of pigmentation genes in horses. Watt B; Tenza D; Lemmon MA (2011) Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathog[...] Andersson LS; Wilbe M; Viluma A (2013) Equine multiple congenital ocular anomalies and silver coat colour result from the pleiotropic effec[...]	GP00002271	Pmel Q60696	Morphology	g.73665304C>T p.R625C	Equus caballus horse - (species)	Equus caballus horse - (species) D		PMEL17	Equus caballus horse - (species)	Published - Accepted by Curator
PMR1	Metal tolerance (manganese)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Sadhu MJ; Bloom JS; Day L ; et al. (2016) CRISPR-directed mitotic recombination enables genetic mapping without crosses.	GP00000914	PMR1 P13586	Physiology	Leu548Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		PMR1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
poils au dos (pad)	Bristle number (thorax)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Gibert JM; Marcellini S; David JR ; et al. (2005) A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription [...]	GP00000915	pad Q9VEW6	Morphology	29bp deletion N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		poils au dos (pad)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
pot-2	Telomere length	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Cook DE; Zdraljevic S; Tanny RE ; et al. (2016) The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.	GP00001317	pot-2 O45595	Physiology	Phenylalanine-to-isoleucine (F68I) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		pot-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
Potassium channel subfamily K	Fin morphology (skeleton; dorsal fin; caudal fin; tail; paired fin)	Coding, SNP N	Carassius auratus goldfish - (species) D	Domesticated	Association Mapping	Kon T; Omori Y; Fukuta K ; et al. (2020) The Genetic Basis of Morphological Diversity in Domesticated Goldfish.	GP00002348	KCNK5 O95279	Morphology	Substitution of a hydrophobic amino acid (valine) with a hydrophilic amino acid (glutamic acid) appears to cause a critical alteration of channel gating. In total there are five amino acid substitutions or deletions in kcnk5bS in goldfish with the long-tail phenotype. N	Carassius auratus goldfish - (species)	Carassius auratus goldfish - (species) D		Potassium channel subfamily K	Carassius auratus goldfish - (species)	Published - Accepted by Curator
PPAR-delta	Ear size Skin aspect	Coding, SNP	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Ren J; Duan Y; Qiao R ; et al. (2011) A missense mutation in PPARD causes a major QTL effect on ear size in pigs.	GP00000919	PPARD Q03181	Morphology Morphology	G32E	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)		PPAR-delta	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
PpeGID1c	Plant size (dwarfism)	Coding, SNP N	Prunus persica peach - (species) D	Domesticated	Linkage Mapping	Hollender CA; Hadiarto T; Srinivasan C ; et al. (2016) A brachytic dwarfism trait (dw) in peach trees is caused by a nonsense mutation within the gibberell[...]	GP00000920	GID1C Q940G6	Morphology	Trp162* (TGG>TAG) N	Prunus persica peach - (species)	Prunus persica peach - (species) D		PpeGID1c	Prunus persica peach - (species)	Published - Accepted by Curator
ppw-1	Resistance to dsRNA	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Linkage Mapping	Tijsterman M; Okihara KL; Thijssen K ; et al. (2002) PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]	GP00000921		Physiology	1bp deletion resulting in stop codon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		ppw-1	Caenorhabditis elegans (species)	Published - Accepted by Curator
PRDM9	Recombination rate (male)	Coding, Deletion	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Sandor C; Li W; Coppieters W ; et al. (2012) Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.	GP00001640	PRDM9 A6QNW2	Physiology	variation in the C-terminal tandem array of Cys2His2 zinc-finger domains: 22 domains > 20 domains decreasing 6-fold Genome wide hot window usage in Crossing Over	Bos taurus cattle - (species)	Bos taurus cattle - (species)		PRDM9	Bos taurus cattle - (species)	Published - Accepted by Curator
PRDM9	Recombination rate (male)	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Sandor C; Li W; Coppieters W ; et al. (2012) Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.	GP00001641	PRDM9 A6QNW2	Physiology	variation in the C-terminal tandem array of Cys2His2 zinc-finger domains: T68A p.I23K in domain 11 has a major effect. K allele decreasing 30-fold Genome wide hot window usage in Crossing Over compared to I allele	Bos taurus cattle - (species)	Bos taurus cattle - (species)		PRDM9	Bos taurus cattle - (species)	Published - Accepted by Curator
PRDM9	Recombination rate (male)	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Sandor C; Li W; Coppieters W ; et al. (2012) Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.	GP00001642	PRDM9 A6QNW2	Physiology	variation in the C-terminal tandem array of Cys2His2 zinc-finger domains: T20C p.A>Y sustitutions in domains 14. Y allele increasing 6-fold Genome wide hot window usage in Crossing Over	Bos taurus cattle - (species)	Bos taurus cattle - (species)		PRDM9	Bos taurus cattle - (species)	Published - Accepted by Curator
PRKG2	Body size (dwarfism)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Koltes JE; Mishra BP; Kumar D ; et al. (2009) A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Ang[...]	GP00002273	PRKG2 Q13237	Morphology	c.1573C>T p.R525* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		PRKG2	Bos taurus cattle - (species)	Published - Accepted by Curator
PRKG2	Body size (dwarfism)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Koltes JE; Mishra BP; Kumar D ; et al. (2009) A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Ang[...]	GP00002274	PRKG2 Q13237	Morphology	c.2032C>T p.R678* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		PRKG2	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin	Hair length (long)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Littlejohn MD; Henty KM; Tiplady K ; et al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.	GP00002032	PRL P01239	Morphology	g.35105313A>C - c.661A>C - p.C221G	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Prolactin	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin	Hair length (short)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Littlejohn MD; Henty KM; Tiplady K ; et al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.	GP00002033	PRL P01239	Morphology	1-bp deletion in exon 10 that introduces a premature stop codon (p.Leu462*) and loss of 120 C-terminal amino acids from the long isoform of the receptor (ss1067289408; chr20:39136558GC>G) N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Prolactin	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Candidate Gene	Viitala S; Szyda J; Blott S ; et al. (2006) The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...]	GP00000927	PRLR P16471	Physiology	Ser18Asn	Bos taurus cattle - (species)	Bos taurus cattle - (species)		Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Feather (slow-feathering ; delay)	Coding, Deletion	Meleagris gallopavo mexicana (subspecies) D	Domesticated	Association Mapping	Derks MFL; Herrero-Medrano JM; Crooijmans RPMA ; et al. (2018) Early and late feathering in turkey and chicken: same gene but different mutations.	GP00002281	PRLR P16471	Morphology	g.9426018_9426022delTTGGT p.Glu726Aspfs*7 truncated PRLR protein that lacks 98 C-terminal AA ; this truncated PRLR protein is strikingly similar to the protein encoded by the slow feathering K allele in chicken	Meleagris gallopavo mexicana (subspecies)	Meleagris gallopavo mexicana (subspecies) D		Prolactin receptor	Meleagris gallopavo mexicana (subspecies)	Published - Accepted by Curator
Prolactin receptor	Hair (slick ; short ; thermotolerance) Thermoregulation (tolerance to warm climate)	Coding, Deletion N	Bos taurus cattle - (species) D	Domesticated		Littlejohn MD; Henty KM; Tiplady K ; et al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.	GP00002282	PRLR P16471	Morphology Physiology	g.39136559delC p.Leu462* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Hair (slick ; short) Thermoregulation (tolerance to warm climate)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated		Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018) Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.	GP00002283	PRLR P16471	Morphology Physiology	g.39136571C>A p.Ser465* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
Prolactin receptor	Hair (slick ; short) Thermoregulation (tolerance to warm climate)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated		Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018) Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.	GP00002284	PRLR P16471	Morphology Physiology	g.39136666C>T p.Arg497* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Prolactin receptor	Bos taurus cattle - (species)	Published - Accepted by Curator
prophenoloxidase 3 (PPO3)	Immune response (melanotic encapsulation by lamellocytes)	Coding, SNP N	Drosophila sechellia (species) D	Interspecific	Candidate Gene	Dudzic JP; Kondo S; Ueda R ; et al. (2015) Drosophila innate immunity: regional and functional specialization of prophenoloxidases.	GP00001781	PPO3 Q9W1V6	Physiology	amino acid change at position 48 which converts the terminal glutamine residue of the propeptide region to a stop codon, and is predicted to generate a truncated version of the PPO3 protein N	Drosophila simulans (species) Drosophila mauritiana (species)	Drosophila sechellia (species) D		prophenoloxidase 3 (PPO3)	Drosophila sechellia (species)	Published - Accepted by Curator
protein phosphatase	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001534	PF3D7_1012700 Q8IJR8	Physiology	p.Val1157Leu	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D		protein phosphatase	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
protoporphyrinogen oxidase (PPO2 = PPX2L)	Xenobiotic resistance (herbicides)	Coding, Deletion	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt WL; Hager AG; McCormick JS ; et al. (2006) A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase.	GP00000929	PPX2L Q0NZW6	Physiology	3bp deletion; deletion of G210	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D		protoporphyrinogen oxidase (PPO2 = PPX2L)	Amaranthus tuberculatus (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	Coding, Deletion N	Sorghum bicolor sorghum - (species) D	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000930	PRR37 Q0D3B6	Physiology	1bp deletion resulting in frameshift N	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species) D		PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	2 Mutations: Coding SNP N	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000931	PRR37 Q0D3B6	Physiology	2 mutations	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)		PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time	Coding, SNP	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Murphy RL; Klein RR; Morishige DT ; et al. (2011) Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]	GP00000932	PRR37 Q0D3B6	Physiology	K162N	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species)		PRR37 pseudoresponse regulator protein 37	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, SNP N	Oryza sativa Japonica Group Japanese rice - (no rank) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001632	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-2a: L710P missense mutation in the CONSTANS-Co-like and TOC1 domain of the protein N	Oryza sativa rice - (species)	Oryza sativa Japonica Group Japanese rice - (no rank) D		PRR37 pseudoresponse regulator protein 37	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001633	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-1a: a 8-bp deletion at position 1515 leading to frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		PRR37 pseudoresponse regulator protein 37	Oryza sativa rice - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001634	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-1b: Y704H N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		PRR37 pseudoresponse regulator protein 37	Oryza sativa rice - (species)	Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37	Flowering time (heading date)	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Koo BH; Yoo SC; Park JW ; et al. (2013) Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]	GP00001635	PRR37 Q0D3B6	Physiology	Nonfunctional allele PRR37-1c: a premature stop Q705* N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		PRR37 pseudoresponse regulator protein 37	Oryza sativa rice - (species)	Published - Accepted by Curator
PsbHLH = A	Coloration (flowers)	Coding, SNP N	Pisum sativum pea - (species)	Domesticated	Linkage Mapping	Hellens RP; Moreau C; Lin-Wang K ; et al. (2010) Identification of Mendel's white flower character.	GP00000935	BHLH E3SXU4	Morphology	Splice site mutation: a simple G to A transition in a splice donor site that leads to a mis-spliced mRNA with a premature stop codon N	Pisum sativum pea - (species)	Pisum sativum pea - (species)		PsbHLH = A	Pisum sativum pea - (species)	Published - Accepted by Curator
PSMB7	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies)	Domesticated	Linkage Mapping	Clark LA; Tsai KL; Starr AN ; et al. (2011) A missense mutation in the 20S proteasome β2 subunit of Great Danes having harlequin coat patterning[...]	GP00000936	Psmb7 P70195	Morphology	c.146T>G p.V6G	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies)		PSMB7	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
PSST	Xenobiotic resistance (METI-I acaricide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Bajda S; Dermauw W; Panteleri R ; et al. (2017) A mutation in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Tetranychus urti[...]	GP00002635	ND-20 Q9VXK7	Physiology	H92R	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D		PSST	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
PSST	Xenobiotic resistance (METI-I acaricide)	Coding, SNP	Panonychus citri citrus red mite - (species) D	Intraspecific	Candidate Gene	Alavijeh ES; Khajehali J; Snoeck S ; et al. (2020) Molecular and genetic analysis of resistance to METI-I acaricides in Iranian populations of the citr[...]	GP00002636	ND-20 Q9VXK7	Physiology	H92R	Panonychus citri citrus red mite - (species)	Panonychus citri citrus red mite - (species) D		PSST	Panonychus citri citrus red mite - (species)	Published - Accepted by Curator
PTPN1	High-altitude adaptation	Coding, SNP	Locusta migratoria migratory locust - (species) D	Intraspecific	Association Mapping	Ding D; Liu G; Hou L ; et al. (2018) Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan m[...]	GP00002668	P18031NULL	Physiology	one nonsynonymous mutation (c.1046A>T) in PTPN1 in Tibetan locusts which encodes the amino acid substitution p.Asn349Ile at the proline (Pro)-rich domain of PTP1B.	Locusta migratoria migratory locust - (species)	Locusta migratoria migratory locust - (species) D		PTPN1	Locusta migratoria migratory locust - (species)	Published - Accepted by Curator
Q = wheat AP2-like (WAP2)	Inflorescence morphology Spike morphology	Coding, SNP	Triticum turgidum (species)	Domesticated	Linkage Mapping	Simons KJ; Fellers JP; Trick HN ; et al. (2006) Molecular characterization of the major wheat domestication gene Q.	GP00000940	WANT1 C1PH82	Morphology Morphology	V329I	Triticum turgidum (species)	Triticum turgidum (species)		Q = wheat AP2-like (WAP2)	Triticum turgidum (species)	Published - Accepted by Curator
qPE9-1	Plant architecture Inflorescence architecture	Coding, Indel N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Zhou Y; Zhu J; Li Z ; et al. (2009) Deletion in a quantitative trait gene qPE9-1 associated with panicle erectness improves plant archit[...]	GP00000941	PAY1 B8Y995	Morphology Morphology	637-bp deletion and 12-bp insertion resulting in truncated protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		qPE9-1	Oryza sativa rice - (species)	Published - Accepted by Curator
qSW5	Grain size	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Shomura A; Izawa T; Ebana K ; et al. (2008) Deletion in a gene associated with grain size increased yields during rice domestication. 1 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000944	qSW5 F8SPD1	Morphology	1212bp deletion N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		qSW5	Oryza sativa rice - (species)	Published - Accepted by Curator
R/glyma09g36983	Coloration (seeds)	Coding, SNP N	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Gillman JD; Tetlow A; Lee JD ; et al. (2011) Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in [...] 1 Additional References Zabala G; Vodkin LO (2014) Methylation affects transposition and splicing of a large CACTA transposon from a MYB transcription [...]	GP00000946	100780023 K7LFP2	Morphology	C377- creating premature Stop N	Glycine max soybean - (species)	Glycine max soybean - (species)		R/glyma09g36983	Glycine max soybean - (species)	Published - Accepted by Curator
RAC1	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Borhan MH; Holub EB; Beynon JL ; et al. (2004) The arabidopsis TIR-NB-LRR gene RAC1 confers resistance to Albugo candida (white rust) and is depend[...]	GP00000949	ARAC3 Q38912	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RAC1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RAD5	Xenobiotic resistance	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Demogines A; Smith E; Kruglyak L ; et al. (2008) Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. 1 Additional References Ehrenreich IM; Torabi N; Jia Y (2010) Dissection of genetically complex traits with extremely large pools of yeast segregants.	GP00000950	RAD5 P32849	Physiology	I791S	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		RAD5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS1	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000952	RAS2 P01120	Physiology	Glu>Ala (A>C mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RAS1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS1	Salt tolerance Abscisic acid sensitivity	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ren Z; Zheng Z; Chinnusamy V ; et al. (2010) RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis.	GP00000953	RAS1 O04515	Physiology Physiology	Premature stop codon; Lys>STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RAS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RAS2	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000954	RAS2 P01120	Physiology	Gly>Ser (C>T mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RAS2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RAS2	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kohn LM; Anderson JB (2014) The underlying structure of adaptation under strong selection in 12 experimental yeast populations.	GP00000955	RAS2 P01120	Physiology	Glu>Gln (C>G mutation)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RAS2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Rc	Coloration (seed)	Coding, SNP N	Oryza glaberrima African rice - (species)	Domesticated	Candidate Gene	Gross BL; Steffen FT; Olsen KM (2010) The molecular basis of white pericarps in African domesticated rice: novel mutations at the Rc gene.	GP00000958	Rc A7J5U6	Morphology	Premature stop codon in exon 7; Lys>* N	Oryza glaberrima African rice - (species)	Oryza glaberrima African rice - (species)		Rc	Oryza glaberrima African rice - (species)	Published - Accepted by Curator
Rc	Coloration (seed)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Sweeney MT; Thomson MJ; Cho YG ; et al. (2007) Global dissemination of a single mutation conferring white pericarp in rice.	GP00000959	Rc A7J5U6	Morphology	14bp deletion N	Oryza rufipogon (species)	Oryza sativa rice - (species) D		Rc	Oryza sativa rice - (species)	Published - Accepted by Curator
Rc	Coloration (seed)	Coding, SNP N	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sweeney MT; Thomson MJ; Cho YG ; et al. (2007) Global dissemination of a single mutation conferring white pericarp in rice. 2 Additional References Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Sweeney MT; Thomson MJ; Pfeil BE (2006) Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice.	GP00000960	Rc A7J5U6	Morphology	substitution; C->A in exon 6; introduces a premature stop codon (Cys>*) that truncates the protein before the bHLH domain N	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Rc	Oryza sativa rice - (species)	Published - Accepted by Curator
RCR3	Pathogen resistance	Coding, SNP	Solanum peruvianum (species)	Intraspecific	Candidate Gene	Hörger AC; Ilyas M; Stephan W ; et al. (2012) Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathog[...]	GP00000963	Rcr3 Q8S333	Physiology	Candidate amino acid changes are I206K and/or Q222E and/or S330A	Solanum peruvianum (species)	Solanum peruvianum (species)		RCR3	Solanum peruvianum (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001246	At4g11040 Q9T010	Physiology	G892A	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001248	At4g11040 Q9T010	Physiology	-23bp at position 1371 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001249	At4g11040 Q9T010	Physiology	-25bp at position 25 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001250	At4g11040 Q9T010	Physiology	-50bp at position 50; -390bp at position 504 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001251	At4g11040 Q9T010	Physiology	-13bp at position 1440 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001252	At4g11040 Q9T010	Physiology	-2bp at position 1456 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001253	At4g11040 Q9T010	Physiology	-4bp at position 1391 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001254	At4g11040 Q9T010	Physiology	-16bp at position 1054 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001255	At4g11040 Q9T010	Physiology	-19bp at position 594 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001256	At4g11040 Q9T010	Physiology	-2bp at position 606 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001257	At4g11040 Q9T010	Physiology	-4bp at position 11 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001258	At4g11040 Q9T010	Physiology	C684A which causes C135* N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001259	At4g11040 Q9T010	Physiology	4 amino acid changes: N45K; G54R; T55K; E208A - the effect of each single amino acid change has not been tested N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001260	At4g11040 Q9T010	Physiology	-1bp at position 498 causing premature STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RDO5 REDUCED DORMANCY5	Seed dormancy	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Xiang Y; Song B; Née G ; et al. (2016) Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...] 1 Additional References Bentsink L; Hanson J; Hanhart CJ (2010) Natural variation for seed dormancy in Arabidopsis is regulated by additive genetic and molecular pa[...]	GP00001261	At4g11040 Q9T010	Physiology	-1bp at position 498 causing premature STOP N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RDO5 REDUCED DORMANCY5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Rds2	Oxidative stress resistance	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Diezmann S; Dietrich FS (2011) Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major qu[...]	GP00000964	RDS2 P19541	Physiology	H251D	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		Rds2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Reduced height-1 (Rht1)	Plant size (dwarfism)	Coding, SNP N	Helianthus annuus common sunflower - (species) D	Domesticated	Linkage Mapping	Ramos ML; Altieri E; Bulos M ; et al. (2013) Phenotypic characterization, genetic mapping and candidate gene analysis of a source conferring redu[...]	GP00001728	D8 Q9ST48	Morphology	T-to-C transition corresponding to nucleotide positions 143 - the SNP at position 143 converts a leucine residue in a proline within the conserved DELLA motif—This amino acid position corresponds to amino acid position 57 in the full-length amino acid sequence encoded by the L. sativa DELLA1 nucleotide sequence of GenBank Accession No. BAG71200.1 N	Helianthus annuus common sunflower - (species)	Helianthus annuus common sunflower - (species) D		Reduced height-1 (Rht1)	Helianthus annuus common sunflower - (species)	Published - Accepted by Curator
Reduced height-B1 (RhtB1)	Plant size (dwarfism)	Coding, SNP N	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Peng J; Richards DE; Hartley NM ; et al. (1999) 'Green revolution' genes encode mutant gibberellin response modulators.	GP00000965	D8 Q9ST48	Morphology	Q64*; TGA>CGA N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Reduced height-B1 (RhtB1)	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
Reduced height-D1 (RhtD1)	Plant size (dwarfism)	Coding, SNP N	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Peng J; Richards DE; Hartley NM ; et al. (1999) 'Green revolution' genes encode mutant gibberellin response modulators.	GP00000966	D8 Q9ST48	Morphology	E61*; GGA>TGA N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		Reduced height-D1 (RhtD1)	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
ref(2)P	Pathogen resistance (sigma virus)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Dru P; Bras F; Dezélée S ; et al. (1993) Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...] 2 Additional References Carré-Mlouka A; Gaumer S; Gay P (2007) Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo stu[...] Wyers F; Petitjean AM; Dru P (1995) Localization of domains within the Drosophila Ref(2)P protein involved in the intracellular control [...]	GP00001994	ref(2)P P14199	Physiology	Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pn strains. Exact causing mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		ref(2)P	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ref(2)P	Pathogen resistance (sigma virus)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Dru P; Bras F; Dezélée S ; et al. (1993) Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...] 2 Additional References Carré-Mlouka A; Gaumer S; Gay P (2007) Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo stu[...] Wyers F; Petitjean AM; Dru P (1995) Localization of domains within the Drosophila Ref(2)P protein involved in the intracellular control [...]	GP00001995	ref(2)P P14199	Physiology	Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pp strains. Exact causing mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		ref(2)P	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Resistance related Kinase 1 (RKS1)	Pathogen resistance (plant bacteria)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Domesticated	Linkage Mapping	Huard-Chauveau C; Perchepied L; Debieu M ; et al. (2013) An atypical kinase under balancing selection confers broad-spectrum disease resistance in Arabidopsi[...]	GP00001599	F15B8.100 Q9SVY5	Physiology	a single-SNP difference in the coding region resulting in an amino acid change in the activation segment relative to the catalytic kinase loop. Other polymorphisms were found in the 5' and 3' regulatory regions. RKS1-L expression is 235.1 fold higher	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		Resistance related Kinase 1 (RKS1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Thompson M; Shotkoski F; ffrench-Constant R (1993) Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]	GP00000968	Rdl P25123	Physiology	Ala302Ser	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D		resistance to dieldrin	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles arabiensis (species) D	Intraspecific	Candidate Gene	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000969	Rdl P25123	Physiology	Ala302Ser	Anopheles arabiensis (species)	Anopheles arabiensis (species) D		resistance to dieldrin	Anopheles arabiensis (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Du W; Awolola TS; Howell P ; et al. (2005) Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]	GP00000970	Rdl P25123	Physiology	Ala302Gly	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D		resistance to dieldrin	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Alon M; Alon F; Nauen R (2008) Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associat[...]	GP00000971	Rdl P25123	Physiology	2 mutations	Bemisia tabaci (species)	Bemisia tabaci (species) D		resistance to dieldrin	Bemisia tabaci (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Blattella germanica German cockroach - (species) D	Intraspecific	Candidate Gene	Kaku K; Matsumura F (1994) Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]	GP00000972	Rdl P25123	Physiology	Ala302Ser	Blattella germanica German cockroach - (species)	Blattella germanica German cockroach - (species) D		resistance to dieldrin	Blattella germanica German cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Ctenocephalides felis cat flea - (species) D	Intraspecific	Candidate Gene	Bass C; Schroeder I; Turberg A ; et al. (2004) Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]	GP00000973	Rdl P25123	Physiology	Ala302Ser	Ctenocephalides felis cat flea - (species)	Ctenocephalides felis cat flea - (species) D		resistance to dieldrin	Ctenocephalides felis cat flea - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993) A point mutation in a Drosophila GABA receptor confers insecticide resistance. 2 Additional References Lee HJ; Rocheleau T; Zhang HG (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000974	Rdl P25123	Physiology	Ala302Ser - G9155164T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)		resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000975	Rdl P25123	Physiology	Ala302Ser	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Lee HJ; Rocheleau T; Zhang HG ; et al. (1993) Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...] 1 Additional References ffrench-Constant RH; Steichen JC; Rocheleau TA (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00000976	Rdl P25123	Physiology	Ala302Gly	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Hypothenemus hampei coffee berry borer - (species) D	Intraspecific	Candidate Gene	Brun LO; Stuart J; Gaudichon V ; et al. (1995) Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...] 2 Additional References Navarro Lucio; Gongora Carmenza; Benavides Pablo (2010 ) Single nucleotide polymorphism detection at the Hypothenemus hampei Rdl gene by allele-specific PCR [...] Steichen JC; Brun LO (1994 ) A molecular diagnostic for endosulfan insecticide resistance in the coffee berry borer Hypothenemus [...]	GP00000977	Rdl P25123	Physiology	Ala302Ser	Hypothenemus hampei coffee berry borer - (species)	Hypothenemus hampei coffee berry borer - (species) D		resistance to dieldrin	Hypothenemus hampei coffee berry borer - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000978	Rdl P25123	Physiology	Ala302Ser	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		resistance to dieldrin	Musca domestica house fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Anthony N; Unruh T; Ganser D ; et al. (1998) Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.	GP00000979	Rdl P25123	Physiology	Ala302Gly	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D		resistance to dieldrin	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Periplaneta americana American cockroach - (species) D	Intraspecific	Candidate Gene	Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000980	Rdl P25123	Physiology	Ala302Ser	Periplaneta americana American cockroach - (species)	Periplaneta americana American cockroach - (species) D		resistance to dieldrin	Periplaneta americana American cockroach - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Tribolium castaneum red flour beetle - (species)	Intraspecific	Candidate Gene	Miyazaki M; Matsumura F; Beeman RW (1995) DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...] 1 Additional References Thompson M; Steichen JC; ffrench-Constant RH (1993) Conservation of cyclodiene insecticide resistance-associated mutations in insects.	GP00000981	Rdl P25123	Physiology	Ala302Ser	Tribolium castaneum red flour beetle - (species)	Tribolium castaneum red flour beetle - (species)		resistance to dieldrin	Tribolium castaneum red flour beetle - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Le Goff G; Hamon A; Bergé JB ; et al. (2005) Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]	GP00001981	Rdl P25123	Physiology	2 mutations	Drosophila simulans (species)	Drosophila simulans (species) D		resistance to dieldrin	Drosophila simulans (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	ffrench-Constant RH; Steichen JC; Rocheleau TA ; et al. (1993) A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]	GP00001982	Rdl P25123	Physiology	Ala301Ser - The lesion in the RdlMD-RR allele has been described as A302S in print but the amino acid replacement is actually A301S.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		resistance to dieldrin	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Wondji CS; Dabire RK; Tukur Z ; et al. (2011) Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the ma[...]	GP00002557	Rdl P25123	Physiology	2 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D		resistance to dieldrin	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Domingues LN; Guerrero FD; Becker ME ; et al. (2013) Discovery of the Rdl mutation in association with a cyclodiene resistant population of horn flies, H[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002558	Rdl P25123	Physiology	Ala301Ser	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D		resistance to dieldrin	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Tantely ML; Tortosa P; Alout H ; et al. (2010) Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002559	Rdl P25123	Physiology	Ala301Ser	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D		resistance to dieldrin	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Aedes albopictus Asian tiger mosquito - (species) D	Intraspecific	Candidate Gene	Tantely ML; Tortosa P; Alout H ; et al. (2010) Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002560	Rdl P25123	Physiology	Ala301Ser	Aedes albopictus Asian tiger mosquito - (species)	Aedes albopictus Asian tiger mosquito - (species) D		resistance to dieldrin	Aedes albopictus Asian tiger mosquito - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Nakao T; Kawase A; Kinoshita A ; et al. (2011) The A2'N mutation of the RDL gamma-aminobutyric acid receptor conferring fipronil resistance in Laod[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002561	Rdl P25123	Physiology	A301N	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D		resistance to dieldrin	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Experimental Evolution	Candidate Gene	Li A; Yang Y; Wu S ; et al. (2006) Investigation of resistance mechanisms to fipronil in diamondback moth (Lepidoptera: Plutellidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002562	Rdl P25123	Physiology	A302(GGC)--> S302(TCC)	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		resistance to dieldrin	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Sogatella furcifera white-backed planthopper - (species) D	Experimental Evolution	Candidate Gene	Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010 ) Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002563	Rdl P25123	Physiology	2 mutations	Sogatella furcifera white-backed planthopper - (species)	Sogatella furcifera white-backed planthopper - (species) D		resistance to dieldrin	Sogatella furcifera white-backed planthopper - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Oulema oryzae rice leaf beetle - (species) D	Experimental Evolution	Candidate Gene	Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010 ) Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002564	Rdl P25123	Physiology	A301S	Oulema oryzae rice leaf beetle - (species)	Oulema oryzae rice leaf beetle - (species) D		resistance to dieldrin	Oulema oryzae rice leaf beetle - (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Diabrotica virgifera (species) D	Intraspecific	Candidate Gene	Wang H; Coates BS; Chen H ; et al. (2013) Role of a γ-aminobutryic acid (GABA) receptor mutation in the evolution and spread of Diabrotica vir[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002566	Rdl P25123	Physiology	A301S	Diabrotica virgifera (species)	Diabrotica virgifera (species) D		resistance to dieldrin	Diabrotica virgifera (species)	Published - Accepted by Curator
resistance to dieldrin	Xenobiotic resistance (insecticide)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Candidate Gene	Hope M; Menzies M; Kemp D (2010) Identification of a dieldrin resistance-associated mutation in Rhipicephalus (Boophilus) microplus ([...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002567	Rdl P25123	Physiology	T305L	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		resistance to dieldrin	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator
resistant to methyl viologen 1 (RMV1)	Polyamine uptake	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Fujita M; Fujita Y; Iuchi S ; et al. (2012) Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis.	GP00000982	RMV1 Q9FFL1	Physiology	Ile377Phe N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		resistant to methyl viologen 1 (RMV1)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
retr02/eIF(iso)4E	Pathogen resistance (plant virus)	Coding, SNP	Brassica rapa field mustard - (species) D	Domesticated	Linkage Mapping	Qian W; Zhang S; Zhang S ; et al. (2013) Mapping and candidate-gene screening of the novel Turnip mosaic virus resistance gene retr02 in Chin[...]	GP00000983	EIF(ISO)4E O04663	Physiology	G152R	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species) D		retr02/eIF(iso)4E	Brassica rapa field mustard - (species)	Published - Accepted by Curator
RGC2/Dm3	Pathogen resistance	Coding, Unknown	Lactuca serriola (species)	Domesticated	Linkage Mapping	Kuang H; Ochoa OE; Nevo E ; et al. (2006) The disease resistance gene Dm3 is infrequent in natural populations of Lactuca serriola due to dele[...]	GP00000984	RGC2 Q6Y136	Physiology	Various haplotypes detected using PCR - absence of amplification could be due to deletion or to gene conversion	Lactuca serriola (species)	Lactuca serriola (species)		RGC2/Dm3	Lactuca serriola (species)	Published - Accepted by Curator
Rgh4	Pathogen resistance (cyst nematode; parasite)	2 Mutations: Coding SNP	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Liu S; Kandoth PK; Warren SD ; et al. (2012) A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens.	GP00001049	SHMT K4FZF8	Physiology	2 mutations	Glycine max soybean - (species)	Glycine max soybean - (species)		Rgh4	Glycine max soybean - (species)	Published - Accepted by Curator
Rhodopsin (RH1)	Color vision (blue shift)	Coding, SNP	Thunnus orientalis Pacific bluefin tuna - (species) D	Intergeneric or Higher	Candidate Gene	Nakamura Y; Mori K; Saitoh K ; et al. (2013) Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna[...]	GP00001468	rho P35359	Physiology	p.E122Q (G>C)	Percomorphaceae (no rank)	Thunnus orientalis Pacific bluefin tuna - (species) D		Rhodopsin (RH1)	Thunnus orientalis Pacific bluefin tuna - (species)	Published - Accepted by Curator
ribonuclease 1B (RNase1B)	Optimal enzymatic pH	3 Mutations: Coding SNP	Pygathrix nemaeus Red shanked douc langur - (species) D	Intergeneric or Higher	Candidate Gene	Zhang J (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.	GP00000987	RNASE1B Q8SPN3	Physiology	3 mutations	Primates (order)	Pygathrix nemaeus Red shanked douc langur - (species) D		ribonuclease 1B (RNase1B)	Pygathrix nemaeus Red shanked douc langur - (species)	Published - Accepted by Curator
ribonuclease 1B (RNase1B)	Optimal enzymatic pH	3 Mutations: Coding SNP	Colobus guereza mantled guereza - (species)	Intergeneric or Higher	Candidate Gene	Zhang J (2006) Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.	GP00000988	RNASE1B Q8SPN3	Physiology	3 mutations	Primates (order)	Colobus guereza mantled guereza - (species)		ribonuclease 1B (RNase1B)	Colobus guereza mantled guereza - (species)	Published - Accepted by Curator
RIM15	Low-glucose adaptation (experimental evolution)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00000989	RIM15 P43565	Physiology	1bp deletion resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		RIM15	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RNASE1B	Folivory (digestion of bacteria at low pH)	Coding, SNP	Colobus guereza mantled guereza - (species) D Piliocolobus badius western red colobus - (species) D	Intergeneric or Higher	Candidate Gene	Zhou X; Wang B; Pan Q ; et al. (2014) Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]	GP00001412	RNASE1B Q8SPN3	Physiology	p.Arg39Trp	Macaca mulatta Rhesus monkey - (species)	Colobus guereza mantled guereza - (species) D Piliocolobus badius western red colobus - (species) D		RNASE1B	Colobus guereza mantled guereza - (species) Piliocolobus badius western red colobus - (species)	Published - Accepted by Curator
RNASE1B	Folivory (digestion of bacteria at low pH)	Coding, SNP	Rhinopithecus roxellana golden snub-nosed monkey - (species) D Nasalis larvatus proboscis monkey - (species) D Pygathrix nemaeus Red shanked douc langur - (species) D	Intergeneric or Higher	Candidate Gene	Zhou X; Wang B; Pan Q ; et al. (2014) Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]	GP00001413	RNASE1B Q8SPN3	Physiology	p.Arg39Trp	Colobinae (subfamily)	Rhinopithecus roxellana golden snub-nosed monkey - (species) D Nasalis larvatus proboscis monkey - (species) D Pygathrix nemaeus Red shanked douc langur - (species) D		RNASE1B	Rhinopithecus roxellana golden snub-nosed monkey - (species) Nasalis larvatus proboscis monkey - (species) Pygathrix nemaeus Red shanked douc langur - (species)	Published - Accepted by Curator
RNASE1B	Folivory (digestion of bacteria at low pH)	Coding, SNP	Presbytis melalophos mitred leaf monkey - (species) D	Interspecific	Candidate Gene	Zhou X; Wang B; Pan Q ; et al. (2014) Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]	GP00001414	RNASE1B Q8SPN3	Physiology	p.Arg39Gln	Colobinae (subfamily)	Presbytis melalophos mitred leaf monkey - (species) D		RNASE1B	Presbytis melalophos mitred leaf monkey - (species)	Published - Accepted by Curator
RNASE4	High-altitude adaptation (enhanced angiogenesis)	2 Mutations: Coding SNP	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001505	RNASE4 P34096	Physiology	2 mutations	Rhinopithecus avunculus Tonkin snub-nosed monkey - (species)	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) D Rhinopithecus bieti black snub-nosed monkey - (species) D		RNASE4	Rhinopithecus strykeri Burmese snub-nosed monkey - (species) Rhinopithecus bieti black snub-nosed monkey - (species)	Published - Accepted by Curator
RNASE4 [likely pseudo-replicate of other RNASE4 entry by introgression]	High-altitude adaptation (enhanced angiogenesis)	2 Mutations: Coding SNP	Rhinopithecus roxellana golden snub-nosed monkey - (species) D	Interspecific	Association Mapping	Yu L; Wang GD; Ruan J ; et al. (2016) Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]	GP00001506	RNASE4 P34096	Physiology	2 mutations	Rhinopithecus brelichi Gray snub-nosed monkey - (species)	Rhinopithecus roxellana golden snub-nosed monkey - (species) D		RNASE4 [likely pseudo-replicate of other RNASE4 entry by introgression]	Rhinopithecus roxellana golden snub-nosed monkey - (species)	Published - Accepted by Curator
RNF212	Recombination rate (male)	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Sandor C; Li W; Coppieters W ; et al. (2012) Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.	GP00001639	RNF212 Q495C1	Physiology	T>C p.P259S in exon 12 with reduction in Genome-wide recombination rate	Bos taurus cattle - (species)	Bos taurus cattle - (species)		RNF212	Bos taurus cattle - (species)	Published - Accepted by Curator
RORB	gait (saltatorial locomotion)	Coding, SNP	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Association Mapping	Carneiro M; Vieillard J; Andrade P ; et al. (2021) A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits.	GP00002343	RORB F1PET8	Behavior	a change from GT to AT in the 5’ donor site of intron 9 (chr1: 61,103,503bp). The mutation disrupts the normal splicing of RORB.	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		RORB	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
RPP1-WsA	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001002	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1-WsA	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsB	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001003	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1-WsB	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP1-WsC	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Botella MA; Parker JE; Frost LN ; et al. (1998) Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]	GP00001004	RPP1 F4J339	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP1-WsC	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP13	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Interspecific	Linkage Mapping	Rose LE; Bittner-Eddy PD; Langley CH ; et al. (2004) The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsi[...]	GP00001005	RPP13 Q9M667	Physiology	Various haplotypes	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP13	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP2A-RPP2B	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sinapidou E; Williams K; Nott L ; et al. (2004) Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in A[...]	GP00001006	RPP2A P51407	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP2A-RPP2B	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP4	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	van der Biezen EA; Freddie CT; Kahn K ; et al. (2002) Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]	GP00001007	RPP4 F4JNA9	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP5	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	van der Biezen EA; Freddie CT; Kahn K ; et al. (2002) Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001008	RPP5 F4JNB7	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP5	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPP8	Pathogen resistance	Coding, Complex Change	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	McDowell JM; Dhandaydham M; Long TA ; et al. (1998) Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resi[...] 1 Additional References Nemri A; Atwell S; Tarone AM (2010) Genome-wide survey of Arabidopsis natural variation in downy mildew resistance using combined associ[...]	GP00001010	RPP8 Q8W4J9	Physiology	Chimeric fusion of two paralogues followed by coding divergence	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPP8	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, Insertion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Mindrinos M; Katagiri F; Yu GL ; et al. (1994) The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site [...]	GP00001011	RPS2 Q42484	Physiology	10bp insertion close to the 5' end causing a frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS2	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Caicedo AL; Schaal BA; Kunkel BN (1999) Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.	GP00001012	RPS2 Q42484	Physiology	W235* due to G704A N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RPS2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RPS4	Pathogen resistance	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Narusaka M; Shirasu K; Noutoshi Y (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.	GP00001013	RPS4 Q9XGM3	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		RPS4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RRS1	Pathogen resistance	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009) RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens. 1 Additional References Birker D; Heidrich K; Takahara H (2009) A locus conferring resistance to Colletotrichum higginsianum is shared by four geographically distin[...]	GP00001015	RRS1 P0DKH5	Physiology	Premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		RRS1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
RSF1	Sporulation efficiency	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gerke J; Lorenz K; Cohen B (2009) Genetic interactions between transcription factors cause natural variation in yeast.	GP00001016	HFR1 Q9FE22	Physiology	D181G	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		RSF1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Troczka B; Zimmer CT; Elias J ; et al. (2012) Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...] 2 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] Guo L; Wang Y; Zhou X (2014) Functional analysis of a point mutation in the ryanodine receptor of Plutella xylostella (L.) associ[...]	GP00002433	RyR Q24498	Physiology	G4946E	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Troczka B; Zimmer CT; Elias J ; et al. (2012) Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002434	RyR Q24498	Physiology	G4946E due to GGG>GAA	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Steinbach D; Moritz G ; et al. (2017) Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002435	RyR Q24498	Physiology	G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Roditakis E; Steinbach D; Moritz G ; et al. (2017) Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002436	RyR Q24498	Physiology	G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Douris V; Papapostolou KM; Ilias A ; et al. (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002438	RyR Q24498	Physiology	G4903V corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Tuta absoluta (species) D	Intraspecific	Candidate Gene	Douris V; Papapostolou KM; Ilias A ; et al. (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] 1 Additional References Wang X; Cao X; Jiang D (2020) CRISPR/Cas9 mediated ryanodine receptor I4790M knockin confers unequal resistance to diamides in Plu[...]	GP00002439	RyR Q24498	Physiology	I4790M	Tuta absoluta (species)	Tuta absoluta (species) D		RYR	Tuta absoluta (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Guo L; Liang P; Zhou X ; et al. (2014) Novel mutations and mutation combinations of ryanodine receptor in a chlorantraniliprole resistant p[...]	GP00002605	RyR Q24498	Physiology	E1338D Q4594L I4790M)in highly conserved regions of RyR.	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Gong W; Yan HH; Gao L ; et al. (2014) Chlorantraniliprole resistance in the diamondback moth (Lepidoptera: Plutellidae).	GP00002609	RyR Q24498	Physiology	14 amino acid (Q4546-S4559) deletion. RyR transcript levels are lower in resistant strains than in susceptible strains. N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D		RYR	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Yao R; Zhao DD; Zhang S ; et al. (2017) Monitoring and mechanisms of insecticide resistance in Chilo suppressalis (Lepidoptera: Crambidae), [...] 1 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]	GP00002626	RyR Q24498	Physiology	G4946E	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D		RYR	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Wei Y; Yan R; Zhou Q ; et al. (2019) Monitoring and Mechanisms of Chlorantraniliprole Resistance in Chilo suppressalis (Lepidoptera: Cram[...]	GP00002627	RyR Q24498	Physiology	I4758M	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D		RYR	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
RYR	Xenobiotic resistance (insecticide ; diamide)	Coding, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Candidate Gene	Zuo YY; Ma HH; Lu WJ ; et al. (2020) Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide[...] 2 Additional References Douris V; Papapostolou KM; Ilias A (2017) Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...] Kim Juil; Nam Hwa Yeun; Kwon Min (2021 ) Novel diamide resistance-linked mutation in Korean Spodoptera exigua and a LAMP assay based on a mut[...]	GP00002633	RyR Q24498	Physiology	I4743M - corresponds to I4790M in PxRyR	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D		RYR	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
RYR1	Meat content	Coding, SNP	Sus scrofa pig - (species) D	Domesticated	Linkage Mapping	Fujii J; Otsu K; Zorzato F ; et al. (1991) Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.	GP00002338	Ryr1 E9PZQ0	Physiology	p.R615C	Sus scrofa pig - (species)	Sus scrofa pig - (species) D		RYR1	Sus scrofa pig - (species)	Published - Accepted by Curator
S5	Hybrid incompatibility (F1 female sterility)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Chen J; Ding J; Ouyang Y ; et al. (2008) A triallelic system of S5 is a major regulator of the reproductive barrier and compatibility of indi[...]	GP00001020	GRXS5 Q5QLR2	Physiology	2 non-synonymous changes Leu273Phe and Val471Ala segregate perfectly between japonica (Leu-Val) and japonica (Phe-Ala) - the effect of each amino acid chaeg has not been tested	Oryza sativa rice - (species)	Oryza sativa rice - (species)		S5	Oryza sativa rice - (species)	Published - Accepted by Curator
S5 (ORF3-ORF4-ORF5 gene complex)	Hybrid incompatibility (sterility)	Coding, Complex Change	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Yang J; Zhao X; Cheng K ; et al. (2012) A killer-protector system regulates both hybrid sterility and segregation distortion in rice.	GP00001021	GRXS5 Q5QLR2	Physiology	System of alleles at three linked genes resulting in killer-protector system (hybrid incompabilitites)	Oryza sativa rice - (species)	Oryza sativa rice - (species)		S5 (ORF3-ORF4-ORF5 gene complex)	Oryza sativa rice - (species)	Published - Accepted by Curator
SBNO1	Head size	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Taal HR; Pourcain BS; Thiering E ; et al. (2012) Common variants at 12q15 and 12q24 are associated with infant head circumference.	GP00001023	SBNO1 A3KN83	Morphology	Ser729Asn	Homo sapiens human - (species)	Homo sapiens human - (species)		SBNO1	Homo sapiens human - (species)	Published - Accepted by Curator
SCARB1	Carotenoid content	Coding, SNP N	Serinus canaria common canary - (species) D	Intraspecific	Linkage Mapping	Toomey MB; Lopes RJ; Araújo PM ; et al. (2017) High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.	GP00001681	Scarb1 Q61009	Morphology	T>G nucleotide substitution in the splice-donor site immediately downstream of exon 4 of the SCARB1 gene. This mutation results in abnormal splicing; with the most abundant transcript lacking exon 4. Isoform 4 of SCARB1; the most abundant transcript isoform in the white recessive canary; is predicted to lack 68 amino acids; a deficiency which disrupts SCARB1 protein function. N	Serinus canaria common canary - (species)	Serinus canaria common canary - (species) D		SCARB1	Serinus canaria common canary - (species)	Published - Accepted by Curator
scd-2	Diapause	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Reiner DJ; Ailion M; Thomas JH ; et al. (2008) C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]	GP00001026	scd-2 O76411	Physiology	Gly985Arg	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		scd-2	Caenorhabditis elegans (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Mya arenaria (species) D	Intraspecific	Candidate Gene	Bricelj VM; Connell L; Konoki K ; et al. (2005) Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.	GP00000721	SCN4A P35499	Physiology	E945D	Mya arenaria (species)	Mya arenaria (species) D		SCN4A (Nav1.4)	Mya arenaria (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000724	SCN4A P35499	Physiology	G1569D in DIV domain and D1568S in DIV domain with D1568S supposed to increase the resistance - exact causing mutation(s) unknown	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D		SCN4A (Nav1.4)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Rhabdophis tigrinus Tiger keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000725	SCN4A P35499	Physiology	I1555M	Thamnophis elegans Western terrestrial garter snake - (species)	Rhabdophis tigrinus Tiger keelback - (species) D		SCN4A (Nav1.4)	Rhabdophis tigrinus Tiger keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000726	SCN4A P35499	Physiology	D1277E in DIII domain	Thamnophis couchii (species)	Thamnophis atratus (species) D		SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis atratus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000727	SCN4A P35499	Physiology	D1568N in DIV domain	Thamnophis couchii (species)	Thamnophis atratus (species) D		SCN4A (Nav1.4)	Thamnophis atratus (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis couchii (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance. 1 Additional References Feldman CR; Brodie ED; Brodie ED (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.	GP00000728	SCN4A P35499	Physiology	M1276T in DIII domain	Thamnophis atratus (species)	Thamnophis couchii (species) D		SCN4A (Nav1.4)	Thamnophis couchii (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Hebius pryeri Pryer's keelback - (species) D	Interspecific	Candidate Gene	Feldman CR; Brodie ED; Brodie ED ; et al. (2012) Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000729	SCN4A P35499	Physiology	D1227E = D945E in DIII domain	Hebius vibakari Japanese keelback - (species)	Hebius pryeri Pryer's keelback - (species) D		SCN4A (Nav1.4)	Hebius pryeri Pryer's keelback - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000730	SCN4A P35499	Physiology	G1566A in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000731	SCN4A P35499	Physiology	I1561V in DIV domain	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (TTX)	Coding, SNP	Thamnophis sirtalis (species)	Intraspecific	Candidate Gene	Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005) Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. 1 Additional References McGlothlin JW; Kobiela ME; Feldman CR (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00000732	SCN4A P35499	Physiology	I1556L and/or D1568N and/or G1569V	Thamnophis sirtalis (species)	Thamnophis sirtalis (species)		SCN4A (Nav1.4)	Thamnophis sirtalis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Mantella aurantiaca (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001573	SCN4A P35499	Physiology	C>A p.A446D in DI-S6 domain	Anura frogs and toads - (order)	Mantella aurantiaca (species) D		SCN4A (Nav1.4)	Mantella aurantiaca (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Phyllobates terribilis (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001574	SCN4A P35499	Physiology	T>G p.S429A in DI-S6 domain	Anura frogs and toads - (order)	Phyllobates terribilis (species) D		SCN4A (Nav1.4)	Phyllobates terribilis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Phyllobates terribilis (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001575	SCN4A P35499	Physiology	A>G p.I433V in DI-S6 domain	Anura frogs and toads - (order)	Phyllobates terribilis (species) D		SCN4A (Nav1.4)	Phyllobates terribilis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Dendrobates tinctorius dyeing poison frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001576	SCN4A P35499	Physiology	A>G p.I433V in DI-S6 domain	Anura frogs and toads - (order)	Dendrobates tinctorius dyeing poison frog - (species) D		SCN4A (Nav1.4)	Dendrobates tinctorius dyeing poison frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Excidobates captivus Rio Santiago poison frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001577	SCN4A P35499	Physiology	A>G p.I433V in DI-S6 domain	Anura frogs and toads - (order)	Excidobates captivus Rio Santiago poison frog - (species) D		SCN4A (Nav1.4)	Excidobates captivus Rio Santiago poison frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Phyllobates terribilis (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001578	SCN4A P35499	Physiology	C>A p.A446D in DI-S6 domain	Anura frogs and toads - (order)	Phyllobates terribilis (species) D		SCN4A (Nav1.4)	Phyllobates terribilis (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Dendrobates tinctorius dyeing poison frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001579	SCN4A P35499	Physiology	C>A p.A446D in DI-S6 domain	Anura frogs and toads - (order)	Dendrobates tinctorius dyeing poison frog - (species) D		SCN4A (Nav1.4)	Dendrobates tinctorius dyeing poison frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Excidobates captivus Rio Santiago poison frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001580	SCN4A P35499	Physiology	CC>AA p.A446E in DI-S6 domain	Anura frogs and toads - (order)	Excidobates captivus Rio Santiago poison frog - (species) D		SCN4A (Nav1.4)	Excidobates captivus Rio Santiago poison frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Ameerega parvula ruby poison frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001581	SCN4A P35499	Physiology	C>A p.A446D in DI-S6 domain	Anura frogs and toads - (order)	Ameerega parvula ruby poison frog - (species) D		SCN4A (Nav1.4)	Ameerega parvula ruby poison frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Epipedobates phantasmal poison frogs - (genus) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001582	SCN4A P35499	Physiology	C>A p.A446D in DI-S6 domain	Anura frogs and toads - (order)	Epipedobates phantasmal poison frogs - (genus) D		SCN4A (Nav1.4)	Epipedobates phantasmal poison frogs - (genus)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Phyllobates (genus) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001583	SCN4A P35499	Physiology	G>A p.V1583I in DIV-S6 domain	Anura frogs and toads - (order)	Phyllobates (genus) D		SCN4A (Nav1.4)	Phyllobates (genus)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Dendrobates tinctorius dyeing poison frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001584	SCN4A P35499	Physiology	G>A p.V1583I in DIV-S6 domain	Anura frogs and toads - (order)	Dendrobates tinctorius dyeing poison frog - (species) D		SCN4A (Nav1.4)	Dendrobates tinctorius dyeing poison frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Hyloxalus italoi (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001585	SCN4A P35499	Physiology	G>A p.V1583I in DIV-S6 domain	Anura frogs and toads - (order)	Hyloxalus italoi (species) D		SCN4A (Nav1.4)	Hyloxalus italoi (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Ameerega (genus) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001586	SCN4A P35499	Physiology	G>A p.V1583I in DIV-S6 domain	Anura frogs and toads - (order)	Ameerega (genus) D		SCN4A (Nav1.4)	Ameerega (genus)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Silverstoneia flotator rainforest rocket frog - (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001587	SCN4A P35499	Physiology	G>A p.V1583I in DIV-S6 domain	Anura frogs and toads - (order)	Silverstoneia flotator rainforest rocket frog - (species) D		SCN4A (Nav1.4)	Silverstoneia flotator rainforest rocket frog - (species)	Published - Accepted by Curator
SCN4A (Nav1.4)	Xenobiotic resistance (poison frog alkaloids)	Coding, SNP	Phyllobates terribilis (species) D	Intergeneric or Higher	Candidate Gene	Tarvin RD; Santos JC; O'Connell LA ; et al. (2016) Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]	GP00001588	SCN4A P35499	Physiology	C>A p.N1584T in DIV-S6 domain	Anura frogs and toads - (order)	Phyllobates terribilis (species) D		SCN4A (Nav1.4)	Phyllobates terribilis (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000722	SCN4A P35499	Physiology	Y401N	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)		SCN4A (Nav1.4a gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes.	GP00000723	SCN4A P35499	Physiology	Y401C	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)		SCN4A (Nav1.4a gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Tetraodon nigroviridis spotted green pufferfish - (species)	Interspecific	Candidate Gene	Venkatesh B; Lu SQ; Dandona N ; et al. (2005) Genetic basis of tetrodotoxin resistance in pufferfishes. 1 Additional References Jost MC; Hillis DM; Lu Y (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000733	SCN4A P35499	Physiology	E945D	Teleostei teleost fishes - (infraclass)	Tetraodon nigroviridis spotted green pufferfish - (species)		SCN4A (Nav1.4b gene copy)	Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)	Xenobiotic resistance (TTX)	Coding, SNP	Takifugu rubripes torafugu - (species)	Interspecific	Candidate Gene	Jost MC; Hillis DM; Lu Y ; et al. (2008) Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.	GP00000734	SCN4A P35499	Physiology	M1240T	Teleostei teleost fishes - (infraclass)	Takifugu rubripes torafugu - (species)		SCN4A (Nav1.4b gene copy)	Takifugu rubripes torafugu - (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Viperidae (family) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001652	SCN8A A0A1B0Z7A5	Physiology	I1709V in DIV (2x resistance)	Protobothrops flavoviridis (species)	Viperidae (family) D		SCN8A (Nav1.6)	Viperidae (family)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Micrurus fulvius eastern coral snake - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001653	SCN8A A0A1B0Z7H0	Physiology	I1709V in DIV domain (2x resistance)	Naja kaouthia monocled cobra - (species)	Micrurus fulvius eastern coral snake - (species) D		SCN8A (Nav1.6)	Micrurus fulvius eastern coral snake - (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Elapsoidea nigra (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001654	SCN8A A0A1B0Z7G3	Physiology	I1709V in DIV domain (2x resistance)	Naja kaouthia monocled cobra - (species)	Elapsoidea nigra (species) D		SCN8A (Nav1.6)	Elapsoidea nigra (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Erythrolamprus epinephelus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001655	SCN8A A0A1B0Z7B3	Physiology	G1717M in DIV domain (not tested)	Erythrolamprus poecilogyrus (species)	Erythrolamprus epinephelus (species) D		SCN8A (Nav1.6)	Erythrolamprus epinephelus (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Lygophis anomalus (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001656	SCN8A A0A1B0Z7F2	Physiology	V1709I (reversion) in DIV domain (loss of resistance)	Helicops angulatus (species)	Lygophis anomalus (species) D		SCN8A (Nav1.6)	Lygophis anomalus (species)	Published - Accepted by Curator
SCN8A (Nav1.6)	Xenobiotic resistance (TTX)	Coding, SNP	Natricinae (subfamily) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001657	SCN8A A0A1B0Z7B0	Physiology	V1709I (reversion) in DIV (loss of resistance)	Hebius pryeri Pryer's keelback - (species)	Natricinae (subfamily) D		SCN8A (Nav1.6)	Natricinae (subfamily)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Anilios bituberculatus prong-snouted blind snake - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001643	SCN9A Q15858	Physiology	M1392A in DIII domain (not tested)	Anolis carolinensis green anole - (species)	Anilios bituberculatus prong-snouted blind snake - (species) D		SCN9A (Nav1.7)	Anilios bituberculatus prong-snouted blind snake - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Henophidia (superfamily) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001644	SCN9A Q15858	Physiology	M1392T in DIII (15x resistance)	Anolis carolinensis green anole - (species)	Henophidia (superfamily) D		SCN9A (Nav1.7)	Henophidia (superfamily)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Chrysemys picta painted turtle - (species) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001645	SCN9A Q15858	Physiology	D1393P (most probably E>P) in DIII domain (not tested)	Gallus gallus chicken - (species)	Chrysemys picta painted turtle - (species) D		SCN9A (Nav1.7)	Chrysemys picta painted turtle - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Carphophis (genus) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001646	SCN9A Q15858	Physiology	I1677V in DIV (2x resistance)	Diadophis punctatus Ringneck snake - (species)	Carphophis (genus) D		SCN9A (Nav1.7)	Carphophis (genus)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Chrysemys picta painted turtle - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001647	SCN9A Q15858	Physiology	A1681G in DIV domain (1.5x resistance)	Gallus gallus chicken - (species)	Chrysemys picta painted turtle - (species) D		SCN9A (Nav1.7)	Chrysemys picta painted turtle - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Leptotyphlops (genus) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001648	SCN9A Q15858	Physiology	A1681G (1.5x resistance) in DIV	Anilios bituberculatus prong-snouted blind snake - (species)	Leptotyphlops (genus) D		SCN9A (Nav1.7)	Leptotyphlops (genus)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Anolis carolinensis green anole - (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001649	SCN9A Q15858	Physiology	D1684A (most probably N>A) in DIV domain (150x resistance)	Dopasia gracilis Burmese glass lizard - (species)	Anolis carolinensis green anole - (species) D		SCN9A (Nav1.7)	Anolis carolinensis green anole - (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Epicrates cenchria (species) D	Interspecific	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001650	SCN9A Q15858	Physiology	D1684H (most probably N>H) in DIV domain (not tested)	Boa constrictor boa - (species)	Epicrates cenchria (species) D		SCN9A (Nav1.7)	Epicrates cenchria (species)	Published - Accepted by Curator
SCN9A (Nav1.7)	Xenobiotic resistance (TTX)	Coding, SNP	Leptotyphlops (genus) D	Intergeneric or Higher	Candidate Gene	McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016) Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.	GP00001651	SCN9A Q15858	Physiology	G1685Y (not tested) in DIV	Anilios bituberculatus prong-snouted blind snake - (species)	Leptotyphlops (genus) D		SCN9A (Nav1.7)	Leptotyphlops (genus)	Published - Accepted by Curator
SCR	Self-incompatibility (loss)	Coding, Inversion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Candidate Gene	Tsuchimatsu T; Suwabe K; Shimizu-Inatsugi R ; et al. (2010) Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene. 1 Additional References Shimizu KK; Shimizu-Inatsugi R; Tsuchimatsu T (2008) Independent origins of self-compatibility in Arabidopsis thaliana.	GP00001271	SCRA P0CG07	Physiology	213 bp inversion causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		SCR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SCRB15	Coloration (silk; carotenoids)	Coding, Insertion N	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Sakudoh T; Kuwazaki S; Iizuka T ; et al. (2013) CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the si[...]	GP00001904	SCRB15 K7ZRZ1	Morphology	In the F mutant SCRB15 mRNA structure was severely disrupted due to a 1.4 kb genomic insertion in a coding exon N	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D		SCRB15	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (height)	2 Mutations: Coding SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Asano K; Yamasaki M; Takuno S ; et al. (2011) Artificial selection for a green revolution gene during japonica rice domestication.	GP00001027	GA20OX2 Q0JH50	Morphology	2 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice. 3 Additional References Ashikari M; Sakakibara H; Lin S (2005) Cytokinin oxidase regulates rice grain production. Monna L; Kitazawa N; Yoshino R (2002) Positional cloning of rice semidwarfing gene, sd-1: rice "green revolution gene" encodes a mutant en[...] Spielmeyer W; Ellis MH; Chandler PM (2002) Semidwarf (sd-1), "green revolution" rice, contains a defective gibberellin 20-oxidase gene.	GP00001028	GA20OX2 Q0JH50	Morphology	383bp deletion introducing premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice.	GP00001029	GA20OX2 Q0JH50	Morphology	G94V	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice.	GP00001030	GA20OX2 Q0JH50	Morphology	D349H	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
Sd1 (=GA20ox-2)	Plant size (dwarfism)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Candidate Gene	Sasaki A; Ashikari M; Ueguchi-Tanaka M ; et al. (2002) Green revolution: a mutant gibberellin-synthesis gene in rice.	GP00001031	GA20OX2 Q0JH50	Morphology	L266F	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Sd1 (=GA20ox-2)	Oryza sativa rice - (species)	Published - Accepted by Curator
se5	Flowering time	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Izawa T; Oikawa T; Tokutomi S ; et al. (2000) Phytochromes confer the photoperiodic control of flowering in rice (a short-day plant).	GP00001034	HO1 Q69XJ4	Physiology	1bp deletion in exon 1; causes a frameshift and a premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		se5	Oryza sativa rice - (species)	Published - Accepted by Curator
self-pruning (sp)	Vegetative/Reproductive state switch	Coding, SNP	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Pnueli L; Carmel-Goren L; Hareven D ; et al. (1998) The SELF-PRUNING gene of tomato regulates vegetative to reproductive switching of sympodial meristem[...]	GP00001035	SP O82088	Morphology	P76L due to CCT->CTT	Solanum lycopersicum tomato - (species)	Solanum lycopersicum tomato - (species) D		self-pruning (sp)	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Serine/threonine protein kinase RIM15	Nitrogen use (growth efficiency)	Coding, Insertion N	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001500	RIM15 P43565	Physiology	2 bp insertion 459_460insCA shifting the reading frame to cause an early stop codon (null allele) N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Serine/threonine protein kinase RIM15	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SG3/At4g30720	Growth (shoots)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Vlad D; Rappaport F; Simon M ; et al. (2010) Gene transposition causing natural variation for growth in Arabidopsis thaliana.	GP00001036	PDE327 F4JQE2	Physiology	Premature stop codon at the SG3 locus in Bur-0 (a 1bp deletion in exon four of At4g30720 results in a frame shift; predicting a premature stop codon which terminates the ORF after 5 amino acids); but in this accession this gene has a functional copy at a N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		SG3/At4g30720	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
SGK3	Hair (hypotrichosis)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Parker HG; Harris A; Dreger DL ; et al. (2017) The bald and the beautiful: hairlessness in domestic dog breeds.	GP00002262	Sgk3 Q9ERE3	Morphology	Val96GlyfsTer50 deletion that removes four bases (TTAG) within exon 4 ; creating a new protein sequence for 50 amino acids and a premature stop at amino acid 157 N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		SGK3	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
SGK3	Hair (hypotrichosis)	Coding, Insertion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Hytönen MK; Lohi H (2019) A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate g[...] 1 Additional References Parker HG; Whitaker DT; Harris AC (2020) Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration T[...]	GP00002263	Sgk3 Q9ERE3	Morphology	c.137_138insT p.Glu47GlyfsTer3 N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		SGK3	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
SGLT1	Starch processing	Coding, Unknown	Canis lupus familiaris dog - (subspecies)	Domesticated	Association Mapping	Axelsson E; Ratnakumar A; Arendt ML ; et al. (2013) The genomic signature of dog domestication reveals adaptation to a starch-rich diet.	GP00001037	Slc5a1 Q9QXI6	Physiology	unknown	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies)		SGLT1	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
Shattering1 - Sh1	Seed shattering	Coding, Deletion N	Sorghum bicolor sorghum - (species) D	Domesticated	Linkage Mapping	Lin Z; Li X; Shannon LM ; et al. (2012) Parallel domestication of the Shattering1 genes in cereals.	GP00001040	YAB2 Q10FZ7	Physiology	2.2kb deletion at the location of exons 2 and 3 N	Sorghum virgatum (species)	Sorghum bicolor sorghum - (species) D		Shattering1 - Sh1	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
Shattering1 - Sh1	Seed shattering	Coding, Complex Change	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Lin Z; Li X; Shannon LM ; et al. (2012) Parallel domestication of the Shattering1 genes in cereals.	GP00001041	YAB2 Q10FZ7	Physiology	two promoter variants at positions -1194 and -1185	Sorghum virgatum (species)	Sorghum bicolor sorghum - (species)		Shattering1 - Sh1	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
Shattering1 - Sh1	Seed shattering	Coding, SNP	Sorghum bicolor sorghum - (species)	Domesticated	Linkage Mapping	Lin Z; Li X; Shannon LM ; et al. (2012) Parallel domestication of the Shattering1 genes in cereals.	GP00001042	YAB2 Q10FZ7	Physiology	GT-to-GG splice-site variant	Sorghum virgatum (species)	Sorghum bicolor sorghum - (species)		Shattering1 - Sh1	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
Shattering1 - ZmSh1-1	Seed shattering	Coding, Complex Change	Zea mays (species)	Domesticated	Association Mapping	Lin Z; Li X; Shannon LM ; et al. (2012) Parallel domestication of the Shattering1 genes in cereals.	GP00001043	YAB2 Q10FZ7	Physiology	complex structural variations	Zea mays (species)	Zea mays (species)		Shattering1 - ZmSh1-1	Zea mays (species)	Published - Accepted by Curator
Shattering1 - ZmSh1-5.1 + ZmSh1-5.2	Seed shattering	Coding, Unknown	Zea mays (species)	Domesticated	Association Mapping	Lin Z; Li X; Shannon LM ; et al. (2012) Parallel domestication of the Shattering1 genes in cereals.	GP00001044	YAB2 Q10FZ7	Physiology	various structural variations	Zea mays (species)	Zea mays (species)		Shattering1 - ZmSh1-5.1 + ZmSh1-5.2	Zea mays (species)	Published - Accepted by Curator
shattering4 - sh4	Seed shattering	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Li C; Zhou A; Sang T (2006) Rice domestication by reducing shattering.	GP00001046	sh4 Q1PIH9	Physiology	Asn -> Lys	Oryza rufipogon (species)	Oryza sativa rice - (species)		shattering4 - sh4	Oryza sativa rice - (species)	Published - Accepted by Curator
SHELL	Fruit shell thickness	Coding, SNP	Elaeis guineensis African oil palm - (species)	Domesticated	Linkage Mapping	Singh R; Low ET; Ooi LC ; et al. (2013) The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK.	GP00001047	AGL11 Q38836	Morphology	1a.a substitution in DNA binding domain	Elaeis guineensis African oil palm - (species)	Elaeis guineensis African oil palm - (species)		SHELL	Elaeis guineensis African oil palm - (species)	Published - Accepted by Curator
SHELL	Fruit shell thickness	Coding, SNP	Elaeis guineensis African oil palm - (species)	Domesticated	Candidate Gene	Singh R; Low ET; Ooi LC ; et al. (2013) The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK.	GP00001048	AGL11 Q38836	Morphology	1a.a substitution in DNA binding domain	Elaeis guineensis African oil palm - (species)	Elaeis guineensis African oil palm - (species)		SHELL	Elaeis guineensis African oil palm - (species)	Published - Accepted by Curator
SIGLEC17P (pseudogene)	Pathogen resistance	Coding, Deletion N	Homo sapiens human - (species) D	Interspecific	Candidate Gene	Wang X; Mitra N; Secundino I ; et al. (2012) Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.	GP00001053	SIGLEC13 Q64JA4	Physiology	1bp deletion resulting in frame-shift (pseudogenization) N	Primates (order)	Homo sapiens human - (species) D		SIGLEC17P (pseudogene)	Homo sapiens human - (species)	Published - Accepted by Curator
SIR2	Longevity	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Intraspecific	Linkage Mapping	Gresham D; Desai MM; Tucker CM ; et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]	GP00001054	SIR2 P06700	Physiology	1 to 5 amino-acid substitutions	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		SIR2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SKC1 =OsHKT1	Salt tolerance	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Ren ZH; Gao JP; Li LG ; et al. (2005) A rice quantitative trait locus for salt tolerance encodes a sodium transporter.	GP00001055	HKT8 A2WNZ9	Physiology	several candidate missense mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species)		SKC1 =OsHKT1	Oryza sativa rice - (species)	Published - Accepted by Curator
SLC24A	Coloration (eyes)	Coding, Deletion N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Mack M; Kowalski E; Grahn R ; et al. (2017) Two Variants in SLC24A5 Are Associated with "Tiger-Eye" Iris Pigmentation in Puerto Rican Paso Fino [...]	GP00002276	Slc24a5 Q8C261	Morphology	628 bp deletion encompassing all of exon 7 of SLC24A5 (c.875-340_1081+82del) N	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC24A	Equus caballus horse - (species)	Published - Accepted by Curator
SLC24A	Coloration (eyes)	Coding, SNP N	Equus caballus horse - (species) D	Domesticated	Association Mapping	Mack M; Kowalski E; Grahn R ; et al. (2017) Two Variants in SLC24A5 Are Associated with "Tiger-Eye" Iris Pigmentation in Puerto Rican Paso Fino [...]	GP00002277	Slc24a5 Q8C261	Morphology	c.272A>T p.Phe91Tyr N	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC24A	Equus caballus horse - (species)	Published - Accepted by Curator
SLC24A5 (NCKX5)	Coloration (eyes; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Lamason RL; Mohideen MA; Mest JR ; et al. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. 5 Additional References Beleza S; Johnson NA; Candille SI (2013) Genetic architecture of skin and eye color in an African-European admixed population. Wakamatsu K; Kavanagh R; Kadekaro AL (2006) Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as[...] Ginger RS; Askew SE; Ogborne RM (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activ[...] Quillen EE; Bauchet M; Bigham AW (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...] Basu Mallick C; Iliescu FM; Möls M (2013) The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.	GP00001056	Slc24a5 Q8C261	Morphology	Ala111Thr	Homo sapiens human - (species)	Homo sapiens human - (species)		SLC24A5 (NCKX5)	Homo sapiens human - (species)	Published - Accepted by Curator
slc2a11b	Coloration (eyes)	Coding, SNP N	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Maclary ET; Phillips B; Wauer R ; et al. (2021) Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia). 2 Additional References Si S; Xu X; Zhuang Y (2021) The genetics and evolution of eye color in domestic pigeons (Columba livia). Andrade P; Gazda MA; Araújo PM (2021) Molecular parallelisms between pigmentation in the avian iris and the integument of ectothermic vert[...]	GP00002367	slc2a11b F6P601	Morphology	"The premature stop codon in pearl-eyed pigeons falls in exon 3 of SLC2A11B, and is predicted to severely truncate the resulting protein from 504 to 57 amino acids." "Based on genotypes at the two coding SNPs in the pearl eye haplotype, we found that gene expression in embryo head samples only shows changes associated with the pearl eye haplotype in SLC2A11B, and not in any other genes within 15 kb of the pearl eye haplotype, further supporting SLC2A11B as the primary candidate for the pearl eye phenotype (supplementary fig. S3A, Supplementary Material online). Embryo heads homozygous for the pearl allele show a significant reduction in SLC2A11B expression (P = 3.94 × 10−6, two-tailed t-test; supplementary fig. S3B, Supplementary Material online). Analysis of read distribution within the SLC2A11B gene shows a decrease in spliced reads specifically within the first three annotated exons, suggesting that alternative splicing or nonsense-mediated decay may be occurring (supplementary fig. S3D, Supplementary Material online)." N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		slc2a11b	Columba livia rock pigeon - (species)	Published - Accepted by Curator
SLC36A1	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Cook D; Brooks S; Bellone R ; et al. (2008) Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses.	GP00002278	SLC36A1 Q7Z2H8	Morphology	c.188C>G p.T63R	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC36A1	Equus caballus horse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Linkage Mapping	Mariat D; Taourit S; Guérin G (2003 Jan-Feb) A mutation in the MATP gene causes the cream coat colour in the horse.	GP00001057	SLC45A2 Q9UMX9	Morphology	c.457G>A p.(Asp153Asn)	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC45A2=MATP	Equus caballus horse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Gunnarsson U; Hellström AR; Tixier-Boichard M ; et al. (2007) Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail.	GP00001058	SLC45A2 Q9UMX9	Morphology	G->T transversion at the splice acceptor site just preceding exon 4; causes in-frame skipping of exon 4	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)		SLC45A2=MATP	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (feathers)	Coding, Deletion N	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Gunnarsson U; Hellström AR; Tixier-Boichard M ; et al. (2007) Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail.	GP00001059	SLC45A2 Q9UMX9	Morphology	1bp deletion at codon 36; resulting in frameshift and a premature stop codon in exon 1; the corresponding mRNA appears to be degraded by Nonsense-mediated mRNA decay. N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		SLC45A2=MATP	Gallus gallus chicken - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (eyes; fur)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Linkage Mapping	Du J; Fisher DE (2002) Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF.	GP00001060	SLC45A2 Q9UMX9	Morphology	N153D	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		SLC45A2=MATP	Mus musculus house mouse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (eyes; hair; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Graf J; Hodgson R; van Daal A (2005) Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation varia[...] 3 Additional References Han J; Kraft P; Nan H (2008) A genome-wide association study identifies novel alleles associated with hair color and skin pigment[...] Quillen EE; Bauchet M; Bigham AW (2012) OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...] Cook AL; Chen W; Thurber AE (2009) Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5[...]	GP00001061	SLC45A2 Q9UMX9	Morphology	Phe374Leu	Homo sapiens human - (species)	Homo sapiens human - (species)		SLC45A2=MATP	Homo sapiens human - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (feathers)	Coding, SNP	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001062	SLC45A2 Q9UMX9	Morphology	His341Arg	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		SLC45A2=MATP	Columba livia rock pigeon - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat)	Coding, SNP	Panthera tigris tiger - (species) D	Intraspecific	Association Mapping	Xu X; Dong GX; Hu XS ; et al. (2013) The genetic basis of white tigers.	GP00001063	SLC45A2 Q9UMX9	Morphology	A477V	Panthera tigris tiger - (species)	Panthera tigris tiger - (species) D		SLC45A2=MATP	Panthera tigris tiger - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat; albinism)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Rothammer S; Kunz E; Seichter D ; et al. (2017) Detection of two non-synonymous SNPs in SLC45A2 on BTA20 as candidate causal mutations for oculocuta[...]	GP00002036	SLC45A2 Q9UMX9	Morphology	exact causing mutation(s) unknown - two possible amino acid changes	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		SLC45A2=MATP	Bos taurus cattle - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (albinism)	Coding, Insertion	Oryzias latipes Japanese medaka - (species) D	Domesticated	Linkage Mapping	Fukamachi S; Shimada A; Shima A (2001) Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka.	GP00002286	SLC45A2 Q9UMX9	Morphology	tandem insertion of 195 nt identical to the adjacent ORF sequence. This tandem repeat produces an insertion of 65 amino acids	Oryzias latipes Japanese medaka - (species)	Oryzias latipes Japanese medaka - (species) D		SLC45A2=MATP	Oryzias latipes Japanese medaka - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (feathers)	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Gunnarsson U; Hellström AR; Tixier-Boichard M ; et al. (2007) Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail.	GP00002294	SLC45A2 Q9UMX9	Morphology	c.1039C>A p.L347M N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		SLC45A2=MATP	Gallus gallus chicken - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (feathers)	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Association Mapping	Gunnarsson U; Hellström AR; Tixier-Boichard M ; et al. (2007) Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail.	GP00002295	SLC45A2 Q9UMX9	Morphology	c.830A>G p.Y277C N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		SLC45A2=MATP	Gallus gallus chicken - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat; albinism)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Winkler PA; Gornik KR; Ramsey DT ; et al. (2014) A partial gene deletion of SLC45A2 causes oculocutaneous albinism in Doberman pinscher dogs.	GP00002296	SLC45A2 Q9UMX9	Morphology	4081 base pair deletion resulting in loss of the terminus of exon seven of SLC45A2 N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		SLC45A2=MATP	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat; albinism)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Wijesena HR; Schmutz SM (2015 May-Jun) A Missense Mutation in SLC45A2 Is Associated with Albinism in Several Small Long Haired Dog Breeds.	GP00002297	SLC45A2 Q9UMX9	Morphology	c.1478G>A p.G493D N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		SLC45A2=MATP	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat; albinism)	Coding, Deletion N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Caduff M; Bauer A; Jagannathan V ; et al. (2017) A single base deletion in the SLC45A2 gene in a Bullmastiff with oculocutaneous albinism.	GP00002298	SLC45A2 Q9UMX9	Morphology	c.1287delC p.Met430CysfsTer4 N	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		SLC45A2=MATP	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Sevane N; Sanz CR; Dunner S (2019) Explicit evidence for a missense mutation in exon 4 of SLC45A2 gene causing the pearl coat dilution [...]	GP00002304	SLC45A2 Q9UMX9	Morphology	c.985G>A p.(Ala329Thr)	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC45A2=MATP	Equus caballus horse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Holl HM; Pflug KM; Yates KM ; et al. (2019) A candidate gene approach identifies variants in SLC45A2 that explain dilute phenotypes, pearl and s[...]	GP00002305	SLC45A2 Q9UMX9	Morphology	c.568G>A p.(Gly190Arg)	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC45A2=MATP	Equus caballus horse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (coat)	Coding, SNP	Equus caballus horse - (species) D	Domesticated	Candidate Gene	Holl HM; Pflug KM; Yates KM ; et al. (2019) A candidate gene approach identifies variants in SLC45A2 that explain dilute phenotypes, pearl and s[...]	GP00002306	SLC45A2 Q9UMX9	Morphology	c.305G>A p.(Arg102Gln)	Equus caballus horse - (species)	Equus caballus horse - (species) D		SLC45A2=MATP	Equus caballus horse - (species)	Published - Accepted by Curator
SLC45A2=MATP	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Gunnarsson U; Hellström AR; Tixier-Boichard M ; et al. (2007) Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail.	GP00002307	SLC45A2 Q9UMX9	Morphology	c.287C>A p.A72D	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)		SLC45A2=MATP	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
SlMYBATV	Coloration (anthocyanin accumulation in fruits)	Coding, Insertion N	Solanum cheesmaniae (species) D	Intraspecific	Linkage Mapping	Cao X; Qiu Z; Wang X ; et al. (2017) A putative R3 MYB repressor is the candidate gene underlying atroviolacium, a locus for anthocyanin [...]	GP00001906	CPC O22059	Morphology; Physiology	SlMYBATV encodes a R3 MYB transcription factor. 4-bp insertion predicted to result in a frame-shift that would alter the protein sequence from amino-acid position 20 onwards by inducing premature termination of translation including the R3/bHLH-binding domain N	Solanum lycopersicum tomato - (species)	Solanum cheesmaniae (species) D		SlMYBATV	Solanum cheesmaniae (species)	Published - Accepted by Curator
SLY41	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001712	SLY41 P22215	Physiology	Trp253Leu (G>T at position 893332 according to Table 1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		SLY41	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
SOD1	Xenobiotic resistance (paraquat)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Tsakas SC; Loukas M ; et al. (2001) Low-activity allele of copper-zinc superoxide dismutase (CuZnSOD) in Drosophila increases paraquat g[...]	GP00001985	Sod1 P61851	Physiology	Insertion of a 0.68kb truncated P-element 47bp downstream of the transcription start site.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		SOD1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Starch branching enzyme (SBEI) = rugosus (R)	Starch structure Seed aspect	Coding, Insertion N	Pisum sativum pea - (species) D	Domesticated	Linkage Mapping	Bhattacharyya MK; Smith AM; Ellis TH ; et al. (1990) The wrinkled-seed character of pea described by Mendel is caused by a transposon-like insertion in a[...]	GP00001078	SBEI Q41058	Physiology Morphology	800 bp TE insertion; probably disrupts the last 61 amino acids of the SBEI protein N	Pisum sativum pea - (species)	Pisum sativum pea - (species) D		Starch branching enzyme (SBEI) = rugosus (R)	Pisum sativum pea - (species)	Published - Accepted by Curator
StCDF1	Latitudinal adaptation	Coding, Insertion N	Solanum tuberosum potato - (species) D	Domesticated	Linkage Mapping	Kloosterman B; Abelenda JA; Gomez Mdel M ; et al. (2013) Naturally occurring allele diversity allows potato cultivation in northern latitudes.	GP00001079	CDF1 Q8W1E3	Physiology	+7bp insertion resulting in frameshift and truncated protein N	Solanum tuberosum potato - (species)	Solanum tuberosum potato - (species) D		StCDF1	Solanum tuberosum potato - (species)	Published - Accepted by Curator
StCDF1	Latitudinal adaptation	Coding, Insertion	Solanum tuberosum potato - (species) D	Domesticated	Linkage Mapping	Kloosterman B; Abelenda JA; Gomez Mdel M ; et al. (2013) Naturally occurring allele diversity allows potato cultivation in northern latitudes.	GP00001080	CDF1 Q8W1E3	Physiology	865bp insertion leading to a fusion protein	Solanum tuberosum potato - (species)	Solanum tuberosum potato - (species) D		StCDF1	Solanum tuberosum potato - (species)	Published - Accepted by Curator
str-217	Xenobiotic resistance (insecticide; DEET)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Candidate Gene	Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018) A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.	GP00001783	str-217 Q9XX85	Physiology	deletion that leads to a predicted frame shift and early stop codon - the predicted resulting protein has only one transmembrane domain instead of the 7 transmembrane domains - 138-bp deletion in exon 2 and 3 and intervening intron according to https://www.wormbase.org/species/c_elegans/variation/WBVar02076179#02-45-3 and email from Emily Dennis from 9 March 2019 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		str-217	Caenorhabditis elegans (species)	Published - Accepted by Curator
str-217	Xenobiotic resistance (insecticide; DEET)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Candidate Gene	Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018) A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.	GP00001784	str-217 Q9XX85	Physiology	on chromosome V position 17000292 G>A stop_gained 13C>T - Gln5* N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D		str-217	Caenorhabditis elegans (species)	Published - Accepted by Curator
sugary 1 (su1) = isoamylase-type starch-debranching enzymes	Fruit sugar content	Coding, SNP	Zea mays (species)	Domesticated	Candidate Gene	Dinges JR; Colleoni C; Myers AM ; et al. (2001) Molecular structure of three mutations at the maize sugary1 locus and their allele-specific phenotyp[...] 1 Additional References James MG; Robertson DS; Myers AM (1995) Characterization of the maize gene sugary1, a determinant of starch composition in kernels.	GP00001082	sugary1 O22637	Physiology	F163L and/or W578R; W738R is more likely to be the mutation responsible as it affect a residue conserved in plants and bacteria	Zea mays (species)	Zea mays (species)		sugary 1 (su1) = isoamylase-type starch-debranching enzymes	Zea mays (species)	Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)	Xenobiotic resistance (oxamniquine)	Coding, Deletion	Schistosoma mansoni (species) D	Intraspecific	Linkage Mapping	Valentim CL; Cioli D; Chevalier FD ; et al. (2013) Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]	GP00001470	SULT-OR G4VLE5	Physiology	E142del	Schistosoma mansoni (species)	Schistosoma mansoni (species) D		Sulfotransferase-OXA-Resistance (SULT-OR)	Schistosoma mansoni (species)	Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)	Xenobiotic resistance (oxamniquine)	Coding, SNP	Schistosoma mansoni (species) D	Intraspecific	Linkage Mapping	Valentim CL; Cioli D; Chevalier FD ; et al. (2013) Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]	GP00001471	SULT-OR G4VLE5	Physiology	C35R (T>C)	Schistosoma mansoni (species)	Schistosoma mansoni (species) D		Sulfotransferase-OXA-Resistance (SULT-OR)	Schistosoma mansoni (species)	Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)	Xenobiotic resistance (oxamniquine)	Coding, SNP	Schistosoma mansoni (species)	Intraspecific	Candidate Gene	Valentim CL; Cioli D; Chevalier FD ; et al. (2013) Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]	GP00001472	SULT-OR G4VLE5	Physiology	F39 Sm > Y54 Sh (T>A) TTT>TAT	Schistosoma mansoni (species)	Schistosoma mansoni (species)		Sulfotransferase-OXA-Resistance (SULT-OR)	Schistosoma mansoni (species)	Published - Accepted by Curator
SVP (SHORT VEGETATIVE PHASE)	Flowering time	Coding, SNP	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Méndez-Vigo B; Martínez-Zapater JM; Alonso-Blanco C (2013) The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic [...]	GP00001087	SVP Q9FVC1	Physiology	Ala32Val	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D		SVP (SHORT VEGETATIVE PHASE)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Linkage Mapping	Coste A; Turner V; Ischer F ; et al. (2006) A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of hetero[...]	GP00001090	TAC1 A7IZW4	Physiology	N977D	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Coding, Deletion	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001092	TAC1 A7IZW4	Physiology	1a.a. deletion	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance	Coding, Deletion	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001093	TAC1 A7IZW4	Physiology	7a.a. deletion	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001094	TAC1 A7IZW4	Physiology	G980E	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001095	TAC1 A7IZW4	Physiology	A736V	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAC1	Xenobiotic resistance (drug)	Coding, SNP	Candida albicans (species) D	Intraspecific	Association Mapping	Coste A; Selmecki A; Forche A ; et al. (2007) Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.	GP00001096	TAC1 A7IZW4	Physiology	T225A	Candida albicans (species)	Candida albicans (species) D		TAC1	Candida albicans (species)	Published - Accepted by Curator
TAF5	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001710	TAF5 P38129	Physiology	Gly693Val (G>T at position 616441 according to Table 1) - GGN to GTN position 616441	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		TAF5	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
TaPHS1	Seed dormancy	Coding, SNP N	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Liu S; Sehgal SK; Li J ; et al. (2013) Cloning and characterization of a critical regulator for preharvest sprouting in wheat.	GP00001104	PHS1 D2J2Y0	Physiology	GT-to-AT transition at the 5_ donor splice site (position +646) of intron 3 AND Premature Stop Codon (position +666) N	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)		TaPHS1	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, Insertion N	Acinonyx jubatus cheetah - (species) D	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001105	Lvrn Q2KHK3	Morphology	1bp insertion resulting in frameshift p.N977Kfs110 N	Acinonyx jubatus cheetah - (species)	Acinonyx jubatus cheetah - (species) D		Taqpep	Acinonyx jubatus cheetah - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001106	Lvrn Q2KHK3	Morphology	D228N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species)	Intraspecific	Candidate Gene	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001107	Lvrn Q2KHK3	Morphology	S59stop N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species)		Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
Taqpep	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species)	Intraspecific	Linkage Mapping	Kaelin CB; Xu X; Hong LZ ; et al. (2012) Specifying and sustaining pigmentation patterns in domestic and wild cats.	GP00001108	Lvrn Q2KHK3	Morphology	W841stop N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species)		Taqpep	Felis catus domestic cat - (species)	Published - Accepted by Curator
TAS1R1	Taste sensitivity (sugar)	Coding, Unknown	Calypte anna Anna's hummingbird - (species) D	Interspecific	Candidate Gene	Baldwin MW; Toda Y; Nakagita T ; et al. (2014) Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancest[...]	GP00001307	T1R1 A0A088DBT6	Physiology	unknown	Gallus gallus chicken - (species)	Calypte anna Anna's hummingbird - (species) D		TAS1R1	Calypte anna Anna's hummingbird - (species)	Published - Accepted by Curator
TAS1R1	Taste sensitivity (umami)	Coding, Deletion N	Ailurus fulgens lesser panda - (species) D	Interspecific	Candidate Gene	Hu Y; Wu Q; Ma S ; et al. (2017) Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas.	GP00001415	Tas1r1 Q99PG6	Physiology	1bp deletion (deletion of a C) in the sixth exon; N	Ursus maritimus polar bear - (species)	Ailurus fulgens lesser panda - (species) D		TAS1R1	Ailurus fulgens lesser panda - (species)	Published - Accepted by Curator
TAS1R1	Taste sensitivity (umami)	Coding, Deletion N	Ailuropoda melanoleuca giant panda - (species) D	Interspecific	Candidate Gene	Li R; Fan W; Tian G ; et al. (2010) The sequence and de novo assembly of the giant panda genome. 2 Additional References Hu Y; Wu Q; Ma S (2017) Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas. Zhao H; Yang JR; Xu H (2010) Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dieta[...]	GP00001416	Tas1r1 Q99PG6	Physiology	pseudogene due to three indel mutations in the third and sixth exons. The giant panda has one 2-bp insertion on the third exon and two deletions (6-bp and 4-bp) on the sixth exon, N	Ursus maritimus polar bear - (species)	Ailuropoda melanoleuca giant panda - (species) D		TAS1R1	Ailuropoda melanoleuca giant panda - (species)	Published - Accepted by Curator
TAS1R2	Taste sensitivity (sugar)	Coding, Deletion N	Felidae cat family - (family) D	Intergeneric or Higher	Candidate Gene	Li X; Li W; Wang H ; et al. (2005) Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. 1 Additional References Li X; Li W; Wang H (2006) Cats lack a sweet taste receptor.	GP00001109	TAS1R2 Q8TE23	Physiology	247bp deletion in exon 3 and stop codons in exons 4 and 6. N	Mammalia mammals - (class)	Felidae cat family - (family) D		TAS1R2	Felidae cat family - (family)	Published - Accepted by Curator
TAS1R3	Taste sensitivity (sugar)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Linkage Mapping	Max M; Shanker YG; Huang L ; et al. (2001) Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. 1 Additional References Montmayeur JP; Liberles SD; Matsunami H (2001) A candidate taste receptor gene near a sweet taste locus.	GP00001110	TAS1R3 Q7RTX0	Physiology	I60T; is predicted to introduce a novel N-linked glycosylation site which might interfere with receptor dimerization	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		TAS1R3	Mus musculus house mouse - (species)	Published - Accepted by Curator
TAS1R3	Taste sensitivity (sugar)	Coding, SNP	Calypte anna Anna's hummingbird - (species) D	Interspecific	Candidate Gene	Baldwin MW; Toda Y; Nakagita T ; et al. (2014) Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancest[...]	GP00001306	T1R3 A0A088DCH0	Physiology	19 nonconsecutive amino acids confer sugar responsiveness and they are confined to three different regions of the protein - change(s) in all 3 regions are required for the acquisition of sugar binding- The exact effect of each single amino acid change has not been tested	Gallus gallus chicken - (species)	Calypte anna Anna's hummingbird - (species) D		TAS1R3	Calypte anna Anna's hummingbird - (species)	Published - Accepted by Curator
TAS2R16	Taste sensitivity (bitter)	Coding, SNP	Lemur catta Ring-tailed lemur - (species) D	Intergeneric or Higher	Candidate Gene	Itoigawa A; Hayakawa T; Suzuki-Hashido N ; et al. (2019) A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in l[...]	GP00001956		Behavior; Physiology	Ser282Leu TCG>TTG	Varecia variegata ruffed lemur - (species) Eulemur macaco black lemur - (species) Eulemur flavifrons Sclater's lemur - (species) Eulemur fulvus brown lemur - (species)	Lemur catta Ring-tailed lemur - (species) D		TAS2R16	Lemur catta Ring-tailed lemur - (species)	Published - Accepted by Curator
TAS2R16	Taste sensitivity (bitter)	Coding, SNP	Varecia variegata ruffed lemur - (species) D Eulemur macaco black lemur - (species) D Eulemur fulvus brown lemur - (species) D Nycticebus pygmaeus pygmy slow loris - (species) D	Intergeneric or Higher	Candidate Gene	Itoigawa A; Hayakawa T; Suzuki-Hashido N ; et al. (2019) A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in l[...]	GP00001957		Behavior; Physiology	Ser282Leu TCG>TTG	Carlito syrichta Philippine tarsier - (species) Trachypithecus poliocephalus White-headed langur - (species)	Varecia variegata ruffed lemur - (species) D Eulemur macaco black lemur - (species) D Eulemur fulvus brown lemur - (species) D Nycticebus pygmaeus pygmy slow loris - (species) D		TAS2R16	Varecia variegata ruffed lemur - (species) Eulemur macaco black lemur - (species) Eulemur fulvus brown lemur - (species) Nycticebus pygmaeus pygmy slow loris - (species)	Published - Accepted by Curator
TAS2R38	Taste sensitivity (bitter)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Kim UK; Jorgenson E; Coon H ; et al. (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthioc[...] 1 Additional References Wooding S; Bufe B; Grassi C (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees.	GP00001111	TAS2R38 P59533	Physiology	P49A and/or A262V and/or V296I	Homo sapiens human - (species)	Homo sapiens human - (species)		TAS2R38	Homo sapiens human - (species)	Published - Accepted by Curator
TAS2R38	Taste sensitivity (bitter)	Coding, SNP	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Wooding S; Bufe B; Grassi C ; et al. (2006) Independent evolution of bitter-taste sensitivity in humans and chimpanzees.	GP00001112	TAS2R38 P59533	Physiology	M1R; eliminates start codon; protein initiates at later Met. Protein apparently null for signalling	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)		TAS2R38	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
TBXT	Organ size (tail; short)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Zhi D; Da L; Liu M ; et al. (2018) Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to t[...] 1 Additional References Han J; Yang M; Guo T (2019) Two linked TBXT (brachyury) gene polymorphisms are associated with the tailless phenotype in fat-rum[...]	GP00002289	Tbxt P20293	Morphology	c.G334T p.G112W	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		TBXT	Ovis aries sheep - (species)	Published - Accepted by Curator
TBXT	Organ size (tail; short)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Buckingham KJ; McMillin MJ; Brassil MM ; et al. (2013) Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats.	GP00002290	Tbxt P20293	Morphology	c.1169delC N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		TBXT	Felis catus domestic cat - (species)	Published - Accepted by Curator
TBXT	Organ size (tail; short)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Buckingham KJ; McMillin MJ; Brassil MM ; et al. (2013) Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats.	GP00002291	Tbxt P20293	Morphology	c.1199delC N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		TBXT	Felis catus domestic cat - (species)	Published - Accepted by Curator
TBXT	Organ size (tail; short)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Buckingham KJ; McMillin MJ; Brassil MM ; et al. (2013) Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats.	GP00002292	Tbxt P20293	Morphology	c.998delT N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		TBXT	Felis catus domestic cat - (species)	Published - Accepted by Curator
TBXT	Organ size (tail; short)	Coding, Indel N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Buckingham KJ; McMillin MJ; Brassil MM ; et al. (2013) Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats.	GP00002293	Tbxt P20293	Morphology	c.998_1014dup17delGCC N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		TBXT	Felis catus domestic cat - (species)	Published - Accepted by Curator
TBXT	Organ size (tail; short)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Linkage Mapping	Haworth K; Putt W; Cattanach B ; et al. (2001) Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target[...] 3 Additional References Jones P; Chase K; Martin A (2008) Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Indrebø A; Langeland M; Juul HM (2008) A study of inherited short tail and taillessness in Pembroke Welsh corgi. Hytönen MK; Grall A; Hédan B (2009 Mar-Apr) Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds.	GP00002340	Tbxt P20293	Morphology	c.189C>G p.I63M	Canis lupus familiaris dog - (subspecies)	Canis lupus familiaris dog - (subspecies) D		TBXT	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
teosinte branched 1 (tb1) = IntC	Plant architecture Inflorescence architecture	Coding, Unknown	Hordeum vulgare (species)	Domesticated	Association Mapping	Ramsay L; Comadran J; Druka A ; et al. (2011) INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domes[...]	GP00001117	TB1 Q93WI2	Morphology Morphology	Large haplotypes; unknown	Hordeum vulgare (species)	Hordeum vulgare (species)		teosinte branched 1 (tb1) = IntC	Hordeum vulgare (species)	Published - Accepted by Curator
teosinte glume architecture (tga1)	Cupule retraction	Coding, SNP	Zea mays (species)	Domesticated	Linkage Mapping	Wang H; Nussbaum-Wagler T; Li B ; et al. (2005) The origin of the naked grains of maize.	GP00001118	TGA1 Q39237	Morphology	K6N; the lysine residue being conserved in rice and wheat	Zea mays (species)	Zea mays (species)		teosinte glume architecture (tga1)	Zea mays (species)	Published - Accepted by Curator
tetraspanin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Association Mapping	Jin L; Wang J; Guan F ; et al. (2018) Dominant point mutation in a tetraspanin gene associated with field-evolved resistance of cotton bol[...]	GP00002468	Tsp2A O46101	Physiology	L31S due to a nucleotide substitution T92C. CRISPR knockout of the tetraspanin gene restored susceptibility to a resistant strain whereas inserting the mutation conferred 125-fold resistance in a susceptible strain.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D		tetraspanin	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
TFL1 / HvCEN	Growth determination habit	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Comadran J; Kilian B; Russell J ; et al. (2012) Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and [...]	GP00001119	TFL1 P93003	Physiology	P135A	Hordeum vulgare (species)	Hordeum vulgare (species)		TFL1 / HvCEN	Hordeum vulgare (species)	Published - Accepted by Curator
TFL1/GmTFL1	Growth determination habit	Coding, SNP	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Tian Z; Wang X; Lee R ; et al. (2010) Artificial selection for determinate growth habit in soybean.	GP00001121	TFL1 P93003	Physiology	R62S	Glycine max soybean - (species)	Glycine max soybean - (species)		TFL1/GmTFL1	Glycine max soybean - (species)	Published - Accepted by Curator
TFL1/GmTFL1	Growth determination habit	Coding, SNP	Glycine max soybean - (species)	Domesticated	Candidate Gene	Tian Z; Wang X; Lee R ; et al. (2010) Artificial selection for determinate growth habit in soybean.	GP00001122	TFL1 P93003	Physiology	P113L	Glycine max soybean - (species)	Glycine max soybean - (species)		TFL1/GmTFL1	Glycine max soybean - (species)	Published - Accepted by Curator
TFL1/GmTFL1	Growth determination habit	Coding, SNP	Glycine max soybean - (species)	Domesticated	Candidate Gene	Tian Z; Wang X; Lee R ; et al. (2010) Artificial selection for determinate growth habit in soybean.	GP00001123	TFL1 P93003	Physiology	R130K	Glycine max soybean - (species)	Glycine max soybean - (species)		TFL1/GmTFL1	Glycine max soybean - (species)	Published - Accepted by Curator
TFL1/GmTFL1	Growth determination habit	Coding, SNP	Glycine max soybean - (species)	Domesticated	Candidate Gene	Tian Z; Wang X; Lee R ; et al. (2010) Artificial selection for determinate growth habit in soybean.	GP00001124	TFL1 P93003	Physiology	R166W	Glycine max soybean - (species)	Glycine max soybean - (species)		TFL1/GmTFL1	Glycine max soybean - (species)	Published - Accepted by Curator
Thermo-tolerance 1 (TT1)	Temperature tolerance	Coding, SNP	Oryza glaberrima African rice - (species) D	Interspecific	Linkage Mapping	Li XM; Chao DY; Wu Y ; et al. (2015) Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of Afri[...]	GP00001566	PAB1 Q10KF0	Physiology	p.R99H	Oryza sativa rice - (species)	Oryza glaberrima African rice - (species) D		Thermo-tolerance 1 (TT1)	Oryza glaberrima African rice - (species)	Published - Accepted by Curator
thioester-containing protein 1	Pathogen resistance (Plasmodium; malaria parasite)	Coding, Unknown	Anopheles coluzzii (species)	Intraspecific	Linkage Mapping	Blandin SA; Wang-Sattler R; Lamacchia M ; et al. (2009) Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. 1 Additional References White BJ; Lawniczak MK; Cheng C (2011) Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodiu[...]	GP00001125	TEP-I Q9GYW4	Physiology	coding change - exact causing mutation(s) unknown	Anopheles gambiae African malaria mosquito - (species)	Anopheles coluzzii (species)		thioester-containing protein 1	Anopheles coluzzii (species)	Published - Accepted by Curator
THOUSAND-GRAIN WEIGHT 6 (TGW6)	Grain yield	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Ishimaru K; Hirotsu N; Madoka Y ; et al. (2013) Loss of function of the IAA-glucose hydrolase gene TGW6 enhances rice grain weight and increases yie[...]	GP00001126	TGW6 Q69U01	Morphology	-1bp at +313 resulting in truncated protein N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		THOUSAND-GRAIN WEIGHT 6 (TGW6)	Oryza sativa rice - (species)	Published - Accepted by Curator
Thyroid stimulating hormone receptor	Metabolism	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Association Mapping	Rubin CJ; Zody MC; Eriksson J ; et al. (2010) Whole-genome resequencing reveals loci under selection during chicken domestication. 1 Additional References Girdland Flink L; Allen R; Barnett R (2014) Establishing the validity of domestication genes using DNA from ancient chickens.	GP00001127	TSHR P16473	Physiology	Gly558Arg	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		Thyroid stimulating hormone receptor	Gallus gallus chicken - (species)	Published - Accepted by Curator
TICAM1	Pathogen resistance (Trypanosoma)	Coding, Unknown	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Noyes H; Brass A; Obara I ; et al. (2011) Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]	GP00001128	TICAM1 Q8IUC6	Physiology	unknown	Bos oxen, cattle - (genus)	Bos taurus cattle - (species)		TICAM1	Bos taurus cattle - (species)	Published - Accepted by Curator
timeless (tim)	Diapause Locomotor activity	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Tauber E; Zordan M; Sandrelli F ; et al. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. 1 Additional References Sandrelli F; Tauber E; Pegoraro M (2007) A molecular basis for natural selection at the timeless locus in Drosophila melanogaster.	GP00001129	TIMELESS Q9UNS1	Physiology Behavior; Physiology	1bp insertion; allows production of longer protein from upstream start codon N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		timeless (tim)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
TMEM154	Pathogen resistance (lentivirus)	Coding, SNP	Ovis aries sheep - (species) D	Intraspecific	Association Mapping	Heaton MP; Clawson ML; Chitko-Mckown CG ; et al. (2012) Reduced lentivirus susceptibility in sheep with TMEM154 mutations.	GP00002242	TMEM154 Q6P9G4	Physiology	Mutation at conserved position associated to resistance in homozygous state	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		TMEM154	Ovis aries sheep - (species)	Published - Accepted by Curator
TMEM263	Body size (dwarfism)	Coding, SNP N	Gallus gallus chicken - (species) D	Domesticated	Linkage Mapping	Wu Z; Derks MFL; Dibbits B ; et al. (2018) A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of Autosomal Dwarfism in Chi[...]	GP00002161		Physiology	g.53688583C>T c.433G>A p.Trp59∗ N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		TMEM263	Gallus gallus chicken - (species)	Published - Accepted by Curator
TMPRSS6	Hematopoiesis (mean blood corpuscular hemoglobin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001618	TMPRSS6 Q8IU80	Physiology	T>C at the associated SNP. Another SNP variant in strong LD p.V736A previously reported to influence iron homeostasis	Homo sapiens human - (species)	Homo sapiens human - (species)		TMPRSS6	Homo sapiens human - (species)	Published - Accepted by Curator
TPCN2	Coloration (coat)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2008) Two newly identified genetic determinants of pigmentation in Europeans.	GP00001131	TPCN2 Q8NHX9	Morphology	Met484Leu and/or Gly734Gln	Homo sapiens human - (species)	Homo sapiens human - (species)		TPCN2	Homo sapiens human - (species)	Published - Accepted by Curator
TPD3	Cell size	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001499	TPD3 P31383	Physiology	C>T p.Q557* heterozygous nonsense mutation which may cause the larger cell size N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		TPD3	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
tra-3 calpain-like protease	Body size (temperature-size interaction)	Coding, SNP	Caenorhabditis elegans (species)	Intraspecific	Linkage Mapping	Kammenga JE; Doroszuk A; Riksen JA ; et al. (2007) A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide pol[...]	GP00001133	tra-3 Q22036	Physiology	F96L	Caenorhabditis elegans (species)	Caenorhabditis elegans (species)		tra-3 calpain-like protease	Caenorhabditis elegans (species)	Published - Accepted by Curator
TRIM5alpha	Pathogen resistance (retroviruses)	Coding, SNP	Cercopithecidae Old World monkeys - (family)	Intraspecific	Candidate Gene	Newman RM; Hall L; Connole M ; et al. (2006) Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.	GP00001135	TRIM5 Q9C035	Physiology	several a.a. substitutions with retrovirus-specific activities; under balancing selection in several species	Cercopithecidae Old World monkeys - (family)	Cercopithecidae Old World monkeys - (family)		TRIM5alpha	Cercopithecidae Old World monkeys - (family)	Published - Accepted by Curator
TRK1	Salt tolerance (ammonium)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Reisser C; Dick C; Kruglyak L ; et al. (2013) Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case.	GP00001139	NTRK1 P04629	Physiology	Candidate a.a substitutions in K12 : C1143S; H551P; E1190G; Q1227K	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)		TRK1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
TRPV4	Ear size (drop)	Coding, SNP	Felis catus domestic cat - (species) D	Domesticated	Association Mapping	Gandolfi B; Alamri S; Darby WG ; et al. (2016) A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats. 1 Additional References Takanosu M; Takanosu T; Suzuki H (2008) Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats.	GP00002279	TRPV4 Q9HBA0	Morphology	c.1024G>T p.V342F	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		TRPV4	Felis catus domestic cat - (species)	Published - Accepted by Curator
tryptophan phenylalanine hydroxylase	Enzymatic activity	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Ruiz-Vázquez P; Silva FJ (1999) Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the in[...]	GP00002003	Hn P17276	Physiology	insertion of the transposable element B104/roo in the exon 3 of the Phenylalanine hydroxylase gene. Its presence alters the Phenylalanine hydroxylase splicing pattern; producing at least two aberrant mRNAs which contain part of the B104 sequence interrupting the coding region. This aberrant splicing is provoked by the use of a cryptic donor site encoded by the B104 3' long terminal repeat in combination with either the gene intron 3 acceptor site or a novel acceptor site generated by the target duplication caused by transposition. One of them; referred as mRNA type 1; encodes a truncated protein that could be predictably non-functional. In mRNA type 2; in spite of a 42 nt insertion; the Phenylalanine hydroxylase reading frame is not altered and it would encode for a protein with 14 extra amino acids which would be able to account for the low enzyme activity detected in this mutant.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		tryptophan phenylalanine hydroxylase	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
TT8	Coloration (seed)	Coding, Insertion N	Brassica rapa field mustard - (species) D	Domesticated	Linkage Mapping	Li X; Chen L; Hong M ; et al. (2012) A large insertion in bHLH transcription factor BrTT8 resulting in yellow seed coat in Brassica rapa.	GP00002077	TT8 Q9FT81	Morphology	insertion of a Helitron transposon of 4320 bp in intron 2 starting with 5' TC and ending with 3'CTAG containing a 17 bp palindromic region forming a hairpin - prevents transcription N	Brassica rapa field mustard - (species)	Brassica rapa field mustard - (species) D		TT8	Brassica rapa field mustard - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, SNP	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Elleder D; Melder DC; Trejbalova K ; et al. (2004) Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]	GP00002256	tva Q6JBY7	Physiology	c.120C>G p.C40W	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Insertion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Elleder D; Melder DC; Trejbalova K ; et al. (2004) Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]	GP00002257	tva Q6JBY7	Physiology	c.48insCTCG N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Chen W; Liu Y; Li H ; et al. (2015) Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]	GP00002258	tva Q6JBY7	Physiology	c.502_511delCGCTCACCCC N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Chen W; Liu Y; Li H ; et al. (2015) Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]	GP00002259	tva Q6JBY7	Physiology	c.502_516delCGCTCACCCCGCCCC N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Reinišová M; Plachý J; Trejbalová K ; et al. (2012) Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]	GP00002260	tva Q6JBY7	Physiology	c.506-515del10 ; splicing N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Tva	Pathogen resistance (virus)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intraspecific	Candidate Gene	Reinišová M; Plachý J; Trejbalová K ; et al. (2012) Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]	GP00002261	tva Q6JBY7	Physiology	c.507-511del5 ; splicing N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		Tva	Gallus gallus chicken - (species)	Published - Accepted by Curator
Twist1	Horn shape (scurs)	Coding, Insertion N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Capitan A; Grohs C; Weiss B ; et al. (2011) A newly described bovine type 2 scurs syndrome segregates with a frame-shift mutation in TWIST1.	GP00002034	Twist1 P26687	Morphology; Physiology	small duplication (c.148_157dup (p.A56RfsX87)) that causes a frameshift and inactivates the gene. N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		Twist1	Bos taurus cattle - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Lyons LA; Imes DL; Rah HC ; et al. (2005) Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus). 1 Additional References Schmidt-Küntzel A; Eizirik E; O'Brien SJ (2005 Jul-Aug) Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of th[...]	GP00001142	Tyr P11344	Morphology	c.679G>T p.G227W	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase (TYR)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Lyons LA; Imes DL; Rah HC ; et al. (2005) Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus). 1 Additional References Schmidt-Küntzel A; Eizirik E; O'Brien SJ (2005 Jul-Aug) Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of th[...]	GP00001143	Tyr P11344	Morphology	c. 940G>A p.G302R	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase (TYR)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (eyes; hair; skin)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. 2 Additional References Sulem P; Gudbjartsson DF; Stacey SN (2008) Two newly identified genetic determinants of pigmentation in Europeans. Gudbjartsson DF; Sulem P; Stacey SN (2008) ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.	GP00001144	Tyr P11344	Morphology	R402Q	Homo sapiens human - (species)	Homo sapiens human - (species)		tyrosinase (TYR)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Panthera leo lion - (species) D	Intraspecific	Association Mapping	Cho YS; Hu L; Hou H ; et al. (2013) The tiger genome and comparative analysis with lion and snow leopard genomes.	GP00001346	Tyr P11344	Morphology	c.260G>A p.Arg87Gln	Panthera leo lion - (species)	Panthera leo lion - (species) D		tyrosinase (TYR)	Panthera leo lion - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin; coat)	Coding, SNP	Equus asinus ass - (species) D	Intraspecific	Candidate Gene	Utzeri VJ; Bertolini F; Ribani A ; et al. (2016) The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation [...]	GP00001347	Tyr P11344	Morphology	c.604C>G p.His202Asp	Equus asinus ass - (species)	Equus asinus ass - (species) D		tyrosinase (TYR)	Equus asinus ass - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin; eye; freckles)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Wilde S; Timpson A; Kirsanow K ; et al. (2014) Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the l[...]	GP00001348	Tyr P11344	Morphology	c. C>A p.Ser192Tyr	Homo sapiens human - (species)	Homo sapiens human - (species) D		tyrosinase (TYR)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (feathers)	Coding, Deletion	Gallus gallus chicken - (species) D	Domesticated	Candidate Gene	Tobita-Teramoto T; Jang GY; Kino K ; et al. (2000) Autosomal albino chicken mutation (ca/ca) deletes hexanucleotide (-deltaGACTGG817) at a copper-bindi[...]	GP00002308	Tyr P11344	Morphology	c.817_822del6 p.237-238delDW	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		tyrosinase (TYR)	Gallus gallus chicken - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (feathers)	Coding, Insertion	Gallus gallus chicken - (species) D	Domesticated	Candidate Gene	Chang CM; Coville JL; Coquerelle G ; et al. (2006) Complete association between a retroviral insertion in the tyrosinase gene and the recessive white m[...]	GP00002309	Tyr P11344	Morphology	insertion of a complete avian retroviral sequence in intron 4 causes aberrant transcripts lacking exon 5	Gallus gallus chicken - (species)	Gallus gallus chicken - (species) D		tyrosinase (TYR)	Gallus gallus chicken - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, Deletion	Mustela putorius furo domestic ferret - (subspecies) D	Domesticated	Linkage Mapping	Blaszczyk WM; Distler C; Dekomien G ; et al. (2007) Identification of a tyrosinase (TYR) exon 4 deletion in albino ferrets (Mustela putorius furo).	GP00002310	Tyr P11344	Morphology	Deletion of exon 4 as detected by Southern Blot	Mustela putorius furo domestic ferret - (subspecies)	Mustela putorius furo domestic ferret - (subspecies) D		tyrosinase (TYR)	Mustela putorius furo domestic ferret - (subspecies)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, Indel	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Yu Y; Grahn RA; Lyons LA (2019) Mocha tyrosinase variant: a new flavour of cat coat coloration.	GP00002311	Tyr P11344	Morphology	c.820_936delinsAATCTC p.I274_L312delinsNL	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase (TYR)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, Deletion N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Imes DL; Geary LA; Grahn RA ; et al. (2006) Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation.	GP00002312	Tyr P11344	Morphology	a cytosine deletion in TYR at position 975 in exon 2 N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase (TYR)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species) D	Domesticated	Candidate Gene	Abitbol M; Bossé P; Grimard B ; et al. (2017) Allelic heterogeneity of albinism in the domestic cat.	GP00002313	Tyr P11344	Morphology	c.1204C>T p.R402* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase (TYR)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin)	Coding, Deletion	Megaptera novaeangliae humpback whale - (species) D	Intraspecific	Candidate Gene	Polanowski AM; Robinson-Laverick SM; Paton D ; et al. (2012 Jan-Feb) Variation in the tyrosinase gene associated with a white humpback whale (Megaptera novaeangliae).	GP00002314	Tyr P11344	Morphology	(264 del C) at codon 88	Megaptera novaeangliae humpback whale - (species)	Megaptera novaeangliae humpback whale - (species) D		tyrosinase (TYR)	Megaptera novaeangliae humpback whale - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, Insertion N	Bos taurus cattle - (species) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Ciobanu DC ; et al. (2004) A form of albinism in cattle is caused by a tyrosinase frameshift mutation.	GP00002315	Tyr P11344	Morphology	c.925_926insC N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D		tyrosinase (TYR)	Bos taurus cattle - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Aigner B; Besenfelder U; Müller M ; et al. (2000) Tyrosinase gene variants in different rabbit strains.	GP00002316	Tyr P11344	Morphology	c.1118C>A p.T373K (also causes albinism in humans)	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		tyrosinase (TYR)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Cavia porcellus domestic guinea pig - (species) D	Domesticated	Candidate Gene	Yu F; Jiao S; Lai W ; et al. (2018) Conserved aspartate-to-glycine mutation in tyrosinase is associated with albino phenotype in domesti[...]	GP00002317	Tyr P11344	Morphology	c.710A>G p.Asp237Gly	Cavia porcellus domestic guinea pig - (species)	Cavia porcellus domestic guinea pig - (species) D		tyrosinase (TYR)	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Bubalus bubalis water buffalo - (species) D	Domesticated	Candidate Gene	Damé MC; Xavier GM; Oliveira-Filho JP ; et al. (2012) A nonsense mutation in the tyrosinase gene causes albinism in water buffalo.	GP00002318	Tyr P11344	Morphology	c.1431G>A p.W477*	Bubalus bubalis water buffalo - (species)	Bubalus bubalis water buffalo - (species) D		tyrosinase (TYR)	Bubalus bubalis water buffalo - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Anistoroaei R; Fredholm M; Christensen K ; et al. (2008) Albinism in the American mink (Neovison vison) is associated with a tyrosinase nonsense mutation.	GP00002319	Tyr P11344	Morphology	c.138T>A p.C46*	Neovison vison American mink - (species)	Neovison vison American mink - (species) D		tyrosinase (TYR)	Neovison vison American mink - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Neovison vison American mink - (species) D	Domesticated	Candidate Gene	Benkel BF; Rouvinen-Watt K; Farid H ; et al. (2009) Molecular characterization of the Himalayan mink.	GP00002320	Tyr P11344	Morphology	c.1835C>G p.H420Q	Neovison vison American mink - (species)	Neovison vison American mink - (species) D		tyrosinase (TYR)	Neovison vison American mink - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (skin)	Coding, SNP	Fejervarya kawamurai (species) D	Intraspecific	Candidate Gene	Miura I; Tagami M; Fujitani T ; et al. (2018) Spontaneous tyrosinase mutations identified in albinos of three wild frog species.	GP00002321	Tyr P11344	Morphology	c.169G>A p.Gly57Arg	Fejervarya kawamurai (species)	Fejervarya kawamurai (species) D		tyrosinase (TYR)	Fejervarya kawamurai (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (albinism)	Coding, SNP N	Sinocyclocheilus anshuiensis (species) D	Interspecific	Candidate Gene	Yang J; Chen X; Bai J ; et al. (2016) The Sinocyclocheilus cavefish genome provides insights into cave adaptation.	GP00002357	Tyr P11344	Morphology; Physiology	G420R amino acid change which is identical to one identified in Caucasian human patients (G419R) http://www.ifpcs.org/albinism/oca1mut.html N	Sinocyclocheilus grahami (species)	Sinocyclocheilus anshuiensis (species) D		tyrosinase (TYR)	Sinocyclocheilus anshuiensis (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (amelanism)	Coding, Insertion N	Oryzias latipes Japanese medaka - (species) D	Domesticated	Candidate Gene	Koga A; Hori H (1997) Albinism due to transposable element insertion in fish.	GP00002372	Tyr P11344	Morphology	"i4 allele was found to contain a 4.7- kb transposable element in the 5th exon" "Tyr-i4 contains a 4.7-kb insertion in exon 5 (Fig. 3). If the inserted fragment was transcribed, the amino acid sequence would be altered after the 469th residue, with a termination codon (UAG) at amino acid position 471. The i4/i4 genotype exhibits a quasi-albino phenotype. This may be explained by generation of a tyrosinase protein that only lacks its C-terminus region. The wild-type tyrosinase has a highly hydrophobic amino acid block at its C terminus (aa 480 - aa 500) which is thought to be part of a membrane spanning domain (Inagaki et al., 1994). A possible explanation is that the mutant tyrosinase encoded by Tyr- i4 lacks this region, so that it cannot be positioned properly on the membrane" N	Oryzias latipes Japanese medaka - (species)	Oryzias latipes Japanese medaka - (species) D		tyrosinase (TYR)	Oryzias latipes Japanese medaka - (species)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat; albinism)	Coding, Deletion N	Nyctereutes procyonoides viverrinus (subspecies) D	Intraspecific	Candidate Gene	Mae Y; Nagara K; Miyazaki M ; et al. (2020) Complex intragene deletion leads to oculocutaneous albinism in tanuki (Japanese raccoon dog).	GP00002374	Tyr P11344	Morphology	"We examined the structure and nucleotide sequence of TYR in an albino tanuki and found that the third exon was removed due to a deletion of approximately 11 kb. In addition, two nonsynonymous nucleotide substitutions were found in the fifth exon. These mutations are possible causes of the albino phenotype; however, the order of occurrence is unclear. Even if the 11-kb deletion was not the first of these mutations, it is considered to cause a total loss of the tyrosinase function because the third exon carries codons for one of the two copper-binding sites of tyrosinase and these sites are essential for the enzyme function. Intriguingly, the deletion was not a simple removal of an 11-kb segment: an internal portion was retained as a segment in the reverse orientation. We propose possible formation processes for this mutation that involve multiple DNA scission events, or an inversion followed by a deletion." N	Nyctereutes procyonoides viverrinus (subspecies)	Nyctereutes procyonoides viverrinus (subspecies) D		tyrosinase (TYR)	Nyctereutes procyonoides viverrinus (subspecies)	Published - Accepted by Curator
tyrosinase (TYR)	Coloration (coat)	Coding, SNP	Cervus elaphus red deer - (species) D	Intraspecific	Candidate Gene	Reiner G; Tramberend K; Nietfeld F ; et al. (2020) A genome-wide scan study identifies a single nucleotide substitution in the tyrosinase gene associat[...]	GP00002375	Tyr P11344	Morphology	"a non-synonymous mutation with exchange of a glycine residue at position 291 of the tyrosinase protein by arginine was identified as the cause of dilution of the coat colour" The mutation is on nucleotide 871 (G > A) but the exact codons are not specified in the paper.	Cervus elaphus red deer - (species)	Cervus elaphus red deer - (species) D		tyrosinase (TYR)	Cervus elaphus red deer - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Berryere TG; Schmutz SM; Schimpf RJ ; et al. (2003) TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?	GP00001145	Tyrp1 P07147	Morphology	c.1300C>T p.H434Y	Bos taurus cattle - (species)	Bos taurus cattle - (species)		tyrosinase-related protein 1 (TYRP1)	Bos taurus cattle - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Deletion	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs.	GP00001146	Tyrp1 P07147	Morphology	deletion of a proline residue in exon 5 (345delP)	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs.	GP00001147	Tyrp1 P07147	Morphology	premature stop codon in exon 5 (Q331ter) N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001149	Tyrp1 P07147	Morphology	Ala23Pro	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		tyrosinase-related protein 1 (TYRP1)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP N	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001150	Tyrp1 P07147	Morphology	Arg72* N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		tyrosinase-related protein 1 (TYRP1)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, Deletion N	Columba livia rock pigeon - (species) D	Domesticated	Linkage Mapping	Domyan ET; Guernsey MW; Kronenberg Z ; et al. (2014) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.	GP00001151	Tyrp1 P07147	Morphology	7-bp deletion 411-418del resulting in null allele N	Columba livia rock pigeon - (species)	Columba livia rock pigeon - (species) D		tyrosinase-related protein 1 (TYRP1)	Columba livia rock pigeon - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP	Coturnix japonica Japanese quail - (species)	Domesticated	Linkage Mapping	Nadeau NJ; Mundy NI; Gourichon D ; et al. (2007) Association of a single-nucleotide substitution in TYRP1 with roux in Japanese quail (Coturnix japon[...]	GP00001152	Tyrp1 P07147	Morphology	Phe282Ser	Coturnix japonica Japanese quail - (species)	Coturnix japonica Japanese quail - (species)		tyrosinase-related protein 1 (TYRP1)	Coturnix japonica Japanese quail - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Schmidt-Küntzel A; Eizirik E; O'Brien SJ ; et al. (2005 Jul-Aug) Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of th[...] 1 Additional References Lyons LA; Foe IT; Rah HC (2005) Chocolate coated cats: TYRP1 mutations for brown color in domestic cats.	GP00001153	Tyrp1 P07147	Morphology	premature UAG stop codon at position 100 of TYRP1; AAG>TAG c.298C>T p.R100* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase-related protein 1 (TYRP1)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Unknown	Felis catus domestic cat - (species) D	Domesticated	Linkage Mapping	Schmidt-Küntzel A; Eizirik E; O'Brien SJ ; et al. (2005 Jul-Aug) Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of th[...]	GP00001154	Tyrp1 P07147	Morphology	Two mutations associated with the chocolate (b) allele - one leading to a TYRP1-A3G substitution in the signal peptide and another to an in-frame insertion TYRP1-421ins17/18 caused by a donor splice site mutation in intron 6 -exact causing change unknown	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D		tyrosinase-related protein 1 (TYRP1)	Felis catus domestic cat - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Kenny EE; Timpson NJ; Sikora M ; et al. (2012) Melanesian blond hair is caused by an amino acid change in TYRP1.	GP00001155	Tyrp1 P07147	Morphology	R93C	Homo sapiens human - (species)	Homo sapiens human - (species) D		tyrosinase-related protein 1 (TYRP1)	Homo sapiens human - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Gratten J; Beraldi D; Lowder BV ; et al. (2007) Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour po[...]	GP00001156	Tyrp1 P07147	Morphology	c. 869G>T p.C290F ; Cys residue involved shows a high degree of evolutionary conservation; it is conserved not only across vertebrates but also in the two paralogues of TYRP1, DCT and TYR	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Deletion	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Candidate Gene	Wu X; Zhang Y; Shen L ; et al. (2016) A 6-bp deletion in exon 8 and two mutations in introns of TYRP1 are associated with blond coat color[...]	GP00001327	Tyrp1 P07147	Morphology	g.17599_17604del 6bp deletion in exon 8 resulting in deletion of Met and Gly residues at positions 495 and 496 in TYRP1 protein ; c.1484_1489del6 p.Met495_Gly496del	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies) D		tyrosinase-related protein 1 (TYRP1)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, SNP	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Li J; Bed'hom B; Marthey S ; et al. (2019) A missense mutation in TYRP1 causes the chocolate plumage color in chicken and alters melanosome str[...]	GP00002126	Tyrp1 P07147	Morphology	g.30830367C>A c.640C>A p.His214Asn	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)		tyrosinase-related protein 1 (TYRP1)	Gallus gallus chicken - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Schmutz SM; Berryere TG; Goldfinch AD (2002) TYRP1 and MC1R genotypes and their effects on coat color in dogs.	GP00002233	Tyrp1 P07147	Morphology	c.121T>A p.Cys41Ser	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Hrckova Turnova E; Majchrakova Z; Bielikova M ; et al. (2017) A novel mutation in the TYRP1 gene associated with brown coat colour in the Australian Shepherd Dog [...]	GP00002234	Tyrp1 P07147	Morphology	c.555T>G p.Tyr185* N	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Canis lupus familiaris dog - (subspecies) D	Domesticated	Candidate Gene	Wright HE; Schofield E; Mellersh CS ; et al. (2019) A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers.	GP00002235	Tyrp1 P07147	Morphology	c.1025T>G p.Phe342Cys	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D		tyrosinase-related protein 1 (TYRP1)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Capra hircus goat - (species) D	Domesticated	Candidate Gene	Becker D; Otto M; Ammann P ; et al. (2015) The brown coat colour of Coppernecked goats is associated with a non-synonymous variant at the TYRP1[...]	GP00002236	Tyrp1 P07147	Morphology	c.1487G>A p.Gly496Asp	Capra hircus goat - (species)	Capra hircus goat - (species) D		tyrosinase-related protein 1 (TYRP1)	Capra hircus goat - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Raadsma HW; Jonas E; Fleet MR ; et al. (2013) QTL and association analysis for skin and fibre pigmentation in sheep provides evidence of a major c[...]	GP00002237	Tyrp1 P07147	Morphology	c.2240C>G p.A746V	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Paris JM; Letko A; Häfliger IM ; et al. (2019) Identification of two TYRP1 loss-of-function alleles in Valais Red sheep.	GP00002238	Tyrp1 P07147	Morphology	c.86_87delGA p.(Glu29ValfsTer5) N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Paris JM; Letko A; Häfliger IM ; et al. (2019) Identification of two TYRP1 loss-of-function alleles in Valais Red sheep.	GP00002239	Tyrp1 P07147	Morphology	c.1066C>T p.(Arg356*) N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D		tyrosinase-related protein 1 (TYRP1)	Ovis aries sheep - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (coat)	Coding, SNP N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Linkage Mapping	Utzeri VJ; Ribani A; Fontanesi L (2014) A premature stop codon in the TYRP1 gene is associated with brown coat colour in the European rabbit[...]	GP00002240	Tyrp1 P07147	Morphology	c.570G>A p.Trp190ter N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D		tyrosinase-related protein 1 (TYRP1)	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)	Coloration (feathers)	Coding, Insertion N	Falco cherrug Saker falcon - (species) D	Intraspecific	Candidate Gene	Cortimiglia C; Castiglioni B; Pizzi F ; et al. (2017) Involvement of tyrosinase-related protein 1 gene in the light brown plumage phenotype of Falco cherr[...]	GP00002285	Tyrp1 P07147	Morphology	c.79_80insT in exon 1 resulting in a frameshift change and a premature stop codon at position 81 of the deduced protein sequence ; which in the wild-type form contains 536 amino acids N	Falco cherrug Saker falcon - (species)	Falco cherrug Saker falcon - (species) D		tyrosinase-related protein 1 (TYRP1)	Falco cherrug Saker falcon - (species)	Published - Accepted by Curator
tyrosyl-tRNA synthetase (mt-TyrRS)	Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013) An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...] 1 Additional References Hoekstra LA; Siddiq MA; Montooth KL (2013) Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect o[...]	GP00001972	TyrRS-m Q9W107	Physiology	C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		tyrosyl-tRNA synthetase (mt-TyrRS)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
TZP	Plant growth (hypocotyl growth - light and temperature dependant)	Coding, Insertion N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Michael TP; Burger BT ; et al. (2008) A zinc knuckle protein that negatively controls morning-specific growth in Arabidopsis thaliana.	GP00001269	TZP Q9FIX7	Morphology	8bp insertion causing premature stop N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		TZP	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Ubiquitin-specific peptidase 46 (Usp46)	Escape behavior (immobility in inescapable situations)	Coding, Deletion	Mus musculus house mouse - (species) D	Intraspecific	Linkage Mapping	Tomida S; Mamiya T; Sakamaki H ; et al. (2009) Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and for[...]	GP00001159	Usp46 P62069	Behavior	1a.a. deletion	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D		Ubiquitin-specific peptidase 46 (Usp46)	Mus musculus house mouse - (species)	Published - Accepted by Curator
Ugt86Dd	Xenobiotic resistance (nicotine ; larval stage)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	Marriage TN; King EG; Long AD ; et al. (2014) Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cr[...] 1 Additional References Highfill CA; Tran JH; Nguyen SKT (2017) Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanoga[...]	GP00001406	Ugt86Dd Q9VGT8	Physiology	22-bp frameshift deletion in Ugt86Dd - CRISPR-induced deletions in Ugt86Dd lead to a large reduction in resistance N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D		Ugt86Dd	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Uncoupling protein 1 (UCP1)	Thermoregulation (brown adipose tissue)	Coding, Deletion N	Sus (genus) D	Intergeneric or Higher	Candidate Gene	Berg F; Gustafson U; Andersson L (2006) The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor[...]	GP00001162	Ucp1 P12242	Physiology	deletion of exons 3 to 5 N	Mammalia mammals - (class)	Sus (genus) D		Uncoupling protein 1 (UCP1)	Sus (genus)	Published - Accepted by Curator
Vacuolar transporter chaperone 1	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001290	VTC1 P40046	Physiology	G>T (Asp > Tyr) @ position 289	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 1	Metal tolerance (copper)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001291	VTC1 P40046	Physiology	Pro > His+frameshift @ position 13 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 1	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001292	VTC1 P40046	Physiology	C>A (Ser > Stop) @ position 104 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001293	VTC4 P47075	Physiology	C>T (Trp > Stop) @ position 800 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001294	VTC4 P47075	Physiology	C>A (Glu > Stop) @ position 226 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001295	VTC4 P47075	Physiology	Phe > Ser+frameshift @ position 380 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001296	VTC4 P47075	Physiology	A>G (Tyr > His) @ position 1075	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001297	VTC4 P47075	Physiology	C>T (Trp > Stop) @ position 1320 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001298	VTC4 P47075	Physiology	T>A (Arg > Stop) @ position 757 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vacuolar transporter chaperone 4	Metal tolerance (copper)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Gerstein AC; Ono J; Lo DS ; et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation.	GP00001299	VTC4 P47075	Physiology	C>A (Glu > Stop) @ position 1153 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D		Vacuolar transporter chaperone 4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Linkage Mapping	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001168	VKORC1 Q9BQB6	Physiology	R98W	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001169	VKORC1 Q9BQB6	Physiology	V29L	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001170	VKORC1 Q9BQB6	Physiology	V45A	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (anti-coagulant drug response; warfarin)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. 2 Additional References Takeuchi F; McGinnis R; Bourgeois S (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00001171	VKORC1 Q9BQB6	Physiology	R58G	Homo sapiens human - (species)	Homo sapiens human - (species) D		Vkorc1	Homo sapiens human - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001172	VKORC1 Q9BQB6	Physiology	L128S	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Vkorc1	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus musculus house mouse - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001173	VKORC1 Q9BQB6	Physiology	Y139C	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)		Vkorc1	Mus musculus house mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Mus spretus western wild mouse - (species)	Intraspecific	Candidate Gene	Song Y; Endepols S; Klemann N ; et al. (2011) Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world [...]	GP00001174	VKORC1 Q9BQB6	Physiology	Several candidate coding changes	Mus musculus house mouse - (species)	Mus spretus western wild mouse - (species)		Vkorc1	Mus spretus western wild mouse - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Linkage Mapping	Rost S; Fregin A; Ivaskevicius V ; et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.	GP00001175	VKORC1 Q9BQB6	Physiology	Y139C	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001176	VKORC1 Q9BQB6	Physiology	S56P	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001177	VKORC1 Q9BQB6	Physiology	L128S	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001178	VKORC1 Q9BQB6	Physiology	L128Q	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001179	VKORC1 Q9BQB6	Physiology	L120Q	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Pelz HJ; Rost S; Hünerberg M ; et al. (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001180	VKORC1 Q9BQB6	Physiology	Y139S	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Lasseur R; Longin-Sauvageon C; Videmann B ; et al. (2005) Warfarin resistance in a French strain of rats. 1 Additional References Pelz HJ; Rost S; Hünerberg M (2005) The genetic basis of resistance to anticoagulants in rodents.	GP00001181	VKORC1 Q9BQB6	Physiology	Y139F	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
Vkorc1	Xenobiotic resistance (rodenticide; warfarin)	Coding, SNP	Rattus norvegicus Norway rat - (species)	Intraspecific	Candidate Gene	Tanaka KD; Kawai YK; Ikenaka Y ; et al. (2013) A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.	GP00001182	VKORC1 Q9BQB6	Physiology	R33P	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species)		Vkorc1	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
VPS13A	Latitudinal adaptation	Coding, SNP	Sus scrofa pig - (species) D	Domesticated	Association Mapping	Ai H; Fang X; Yang B ; et al. (2015) Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequen[...]	GP00001571	VPS13A F1SIL5	Physiology	two nonsynonymous substitutions V>G and F>Y - whether both or only one affects the phenotype is unknown	Sus scrofa pig - (species)	Sus scrofa pig - (species) D		VPS13A	Sus scrofa pig - (species)	Published - Accepted by Curator
VRN2	Flowering time	Coding, SNP	Triticum monococcum (species)	Domesticated	Linkage Mapping	Yan L; Loukoianov A; Blechl A ; et al. (2004) The wheat VRN2 gene is a flowering repressor down-regulated by vernalization.	GP00001187	VRN2 Q8W5B1	Physiology	R35W; R is conserved in all of the ZCCT proteins and in all of the CO-like proteins from Arabidopsis; rice; and barley	Triticum monococcum (species)	Triticum monococcum (species)		VRN2	Triticum monococcum (species)	Published - Accepted by Curator
VRS1 = SIX-ROWED SPIKE 1	Plant architecture Inflorescence architecture	Coding, Deletion N	Hordeum vulgare (species) D	Domesticated	Linkage Mapping	Komatsuda T; Pourkheirandish M; He C ; et al. (2007) Six-rowed barley originated from a mutation in a homeodomain-leucine zipper I-class homeobox gene. 1 Additional References Ramsay L; Comadran J; Druka A (2011) INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domes[...]	GP00001189	Vrs1 A1IHK8	Morphology Morphology	1bp deletion resulting in frameshift N	Hordeum vulgare (species)	Hordeum vulgare (species) D		VRS1 = SIX-ROWED SPIKE 1	Hordeum vulgare (species)	Published - Accepted by Curator
VRS1 = SIX-ROWED SPIKE 1	Plant architecture Inflorescence architecture	Coding, Insertion N	Hordeum vulgare (species) D	Domesticated	Linkage Mapping	Komatsuda T; Pourkheirandish M; He C ; et al. (2007) Six-rowed barley originated from a mutation in a homeodomain-leucine zipper I-class homeobox gene. 1 Additional References Ramsay L; Comadran J; Druka A (2011) INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domes[...]	GP00001190	Vrs1 A1IHK8	Morphology Morphology	1bp insertion resulting in frameshift N	Hordeum vulgare (species)	Hordeum vulgare (species) D		VRS1 = SIX-ROWED SPIKE 1	Hordeum vulgare (species)	Published - Accepted by Curator
VRS1 = SIX-ROWED SPIKE 1	Plant architecture Inflorescence architecture	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Komatsuda T; Pourkheirandish M; He C ; et al. (2007) Six-rowed barley originated from a mutation in a homeodomain-leucine zipper I-class homeobox gene. 1 Additional References Ramsay L; Comadran J; Druka A (2011) INTERMEDIUM-C, a modifier of lateral spikelet fertility in barley, is an ortholog of the maize domes[...]	GP00001191	Vrs1 A1IHK8	Morphology Morphology	Phe75Leu	Hordeum vulgare (species)	Hordeum vulgare (species)		VRS1 = SIX-ROWED SPIKE 1	Hordeum vulgare (species)	Published - Accepted by Curator
VvMYBA2	Coloration (fruit)	2 Mutations: Coding N	Vitis vinifera wine grape - (species) D	Domesticated	Linkage Mapping	Fournier-Level A; Le Cunff L; Gomez C ; et al. (2009) Quantitative genetic bases of anthocyanin variation in grape (Vitis vinifera L. ssp. sativa) berry: [...]	GP00001195	VvmybA2 Q6L9M8	Morphology	2 mutations	Vitis vinifera wine grape - (species)	Vitis vinifera wine grape - (species) D		VvMYBA2	Vitis vinifera wine grape - (species)	Published - Accepted by Curator
Waxy /GBSS	Amylose content	Coding, Insertion N	Setaria italica foxtail millet - (species) D	Domesticated	Candidate Gene	Kawase M; Fukunaga K; Kato K (2005) Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]	GP00001201	waxy Q8L699	Physiology	Transposon insertion TS1-7 (Exon 3) N	Setaria italica foxtail millet - (species)	Setaria italica foxtail millet - (species) D		Waxy /GBSS	Setaria italica foxtail millet - (species)	Published - Accepted by Curator
Waxy /GBSS	Amylose content	Coding, Insertion N	Setaria italica foxtail millet - (species) D	Domesticated	Candidate Gene	Kawase M; Fukunaga K; Kato K (2005) Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]	GP00001202	waxy Q8L699	Physiology	Transposon insertion TS1-9 (Exon 10) N	Setaria italica foxtail millet - (species)	Setaria italica foxtail millet - (species) D		Waxy /GBSS	Setaria italica foxtail millet - (species)	Published - Accepted by Curator
Waxy /GBSS	Amylose content (glutinous rice)	Coding, SNP	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Wang ZY; Zheng FQ; Shen GZ ; et al. (1995) The amylose content in rice endosperm is related to the post-transcriptional regulation of the waxy [...] 3 Additional References Hirano HY; Eiguchi M; Sano Y (1998) A single base change altered the regulation of the Waxy gene at the posttranscriptional level during[...] Frances H; Bligh J; Larkin PD (1998) Use of alternate splice sites in granule-bound starch synthase mRNA from low-amylose rice varieties. Olsen KM; Caicedo AL; Polato N (2006) Selection under domestication: evidence for a sweep in the rice waxy genomic region.	GP00001204	waxy Q8L699	Physiology	substitution G->T in the 5' splice site of intron 1	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Waxy /GBSS	Oryza sativa rice - (species)	Published - Accepted by Curator
Waxy /GBSS	Amylose content (glutinous rice)	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Hori Y; Fujimoto R; Sato Y ; et al. (2007) A novel wx mutation caused by insertion of a retrotransposon-like sequence in a glutinous cultivar o[...]	GP00002069	waxy Q8L699	Physiology	23-bp duplication in the second exon which causes loss of the function of granule-bound starch synthase (GBSS) encoded by the Wx gene N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Waxy /GBSS	Oryza sativa rice - (species)	Published - Accepted by Curator
Waxy /GBSS	Amylose content (glutinous rice)	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Hori Y; Fujimoto R; Sato Y ; et al. (2007) A novel wx mutation caused by insertion of a retrotransposon-like sequence in a glutinous cultivar o[...]	GP00002070	waxy Q8L699	Physiology	insertion of 7764 bp in the ninth exon of the wx gene. Transcripts of the 'Oragamochi' wx allele are about 1-kb shorter and the deduced amino acid sequence of the transcript lacks a motif important for GBSS. The 7,764-bp insertion is a retrotransposon-like sequence with long terminal repeats; a primer binding site and a polypurine tract N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D		Waxy /GBSS	Oryza sativa rice - (species)	Published - Accepted by Curator
WDR1	Coloration (flowers; seeds; stems)	Coding, Deletion N	Ipomoea nil Japanese morning glory - (species) D	Domesticated	Candidate Gene	Morita Y; Saitoh M; Hoshino A ; et al. (2006) Isolation of cDNAs for R2R3-MYB, bHLH and WDR transcriptional regulators and identification of c and[...]	GP00002090	InWDR1 Q1JUZ7	Morphology	frameshift mutation caused by a 7 bp insertion in the gene encoding a WDR transcriptional regulator N	Ipomoea nil Japanese morning glory - (species)	Ipomoea nil Japanese morning glory - (species) D		WDR1	Ipomoea nil Japanese morning glory - (species)	Published - Accepted by Curator
WDR1	Coloration (flowers)	Coding, Insertion N	Petunia axillaris (species) D	Domesticated	Candidate Gene	de Vetten N; Quattrocchio F; Mol J ; et al. (1997) The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserve[...]	GP00002093	InWDR1 Q1JUZ7	Morphology	insertion of a 300-bp dTph1 transposon in the WDR gene in the first WD-repeat (321-bp downstream of the transcription start site) N	Petunia axillaris (species)	Petunia axillaris (species) D		WDR1	Petunia axillaris (species)	Published - Accepted by Curator
WIF1	Ear size	Coding, SNP	Sus scrofa pig - (species) D	Domesticated	Candidate Gene	Liang J; Zhang Y; Wang L ; et al. (2019) Molecular cloning of WIF1 and HMGA2 reveals ear-preferential expression while uncovering a missense [...]	GP00002255	WIF1 Q9Y5W5	Morphology	p.Phe236Leu	Sus scrofa pig - (species)	Sus scrofa pig - (species) D		WIF1	Sus scrofa pig - (species)	Published - Accepted by Curator
WRR4	Pathogen resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Borhan MH; Gunn N; Cooper A ; et al. (2008) WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis t[...]	GP00001215	ADR2 Q9C7X0	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)		WRR4	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Xa21	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Song WY; Wang GL; Chen LL ; et al. (1995) A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21.	GP00001217	Xa21 A0PIA3	Physiology	unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Xa21	Oryza sativa rice - (species)	Published - Accepted by Curator
Xa26	Pathogen resistance	Coding, Unknown	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Sun X; Cao Y; Yang Z ; et al. (2004) Xa26, a gene conferring resistance to Xanthomonas oryzae pv. oryzae in rice, encodes an LRR receptor[...]	GP00001218	Xa26 Q00KZ8	Physiology	unknown	Oryza sativa rice - (species)	Oryza sativa rice - (species)		Xa26	Oryza sativa rice - (species)	Published - Accepted by Curator
Y	Coloration (fruit)	Coding, Insertion	Sorghum bicolor sorghum - (species) D	Domesticated	Candidate Gene	Chopra S; Brendel V; Zhang J ; et al. (1999) Molecular characterization of a mutable pigmentation phenotype and isolation of the first active tra[...]	GP00002068	P1 O24579	Morphology	insertion of a transposable element named Candystripe1 (Cs1) in the second intron of the Y gene - Cs1 is 23,018 bp in size and is bordered by 20-bp terminal inverted repeat sequences. It generated a 3-bp target site duplication upon insertion within the Y gene. Cs1 shares features of the CACTA superfamily of transposons.	Sorghum bicolor sorghum - (species)	Sorghum bicolor sorghum - (species) D		Y	Sorghum bicolor sorghum - (species)	Published - Accepted by Curator
yellow	Coloration (body; wing)	Coding, Insertion N	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Heinze SD; Kohlbrenner T; Ippolito D ; et al. (2017) CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body loc[...]	GP00002623	y P09957	Morphology	a 4 bp insertion at amino acid position 67 that causes a frameshift and a premature stop codon N	Musca domestica house fly - (species)	Musca domestica house fly - (species) D		yellow	Musca domestica house fly - (species)	Published - Accepted by Curator
zfl2	Flowering time	Coding, Deletion	Zea mays (species) D	Domesticated	Linkage Mapping	Buckler ES; Holland JB; Bradbury PJ ; et al. (2009) The genetic architecture of maize flowering time.	GP00001226	zfl2 Q5Q1L6	Physiology	16a.a. deletion	Zea mays (species)	Zea mays (species) D		zfl2	Zea mays (species)	Published - Accepted by Curator
β-adrenergic octopamine receptor gene (AOR)	Xenobiotic resistance (amitraz)	Coding, SNP	Rhipicephalus microplus southern cattle tick - (species) D	Intraspecific	Association Mapping	Corley SW; Jonsson NN; Piper EK ; et al. (2013) Mutation in the RmβAOR gene is associated with amitraz resistance in the cattle tick Rhipicephalus m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002396	Oct-TyrR P22270	Physiology	L64I	Rhipicephalus microplus southern cattle tick - (species)	Rhipicephalus microplus southern cattle tick - (species) D		β-adrenergic octopamine receptor gene (AOR)	Rhipicephalus microplus southern cattle tick - (species)	Published - Accepted by Curator