Gephebase

Gephebase Search Results

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Your research retrieved 1660 results.

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Gene	Trait	Mutation	Taxon B	Taxonomic Status	Evidence	Main Reference	Gephe ID	UniProtKB	Trait Category	Mutation Details	Taxon A	Taxon B	Edit Gene-GePhe	Taxon B	Status
18-wheeler	Pathogen resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Candidate Gene	Lazzaro BP; Sackton TB; Clark AG (2006) Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.	GP00000001	18w A1ZBR2	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	18-wheeler	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
ABC transporter pvmrp1	Xenobiotic resistance (multiresistance to antimalarial drugs)	Unknown, Unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Intraspecific	Association Mapping	Pearson RD; Amato R; Auburn S ; et al. (2016) Genomic analysis of local variation and recent evolution in Plasmodium vivax.	GP00001486	PVX_097025 A5KCN4	Physiology	unknown	Plasmodium vivax malaria parasite P. vivax - (species)	Plasmodium vivax malaria parasite P. vivax - (species)	ABC transporter pvmrp1	Plasmodium vivax malaria parasite P. vivax - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Indel N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000002	ABCA2 A0A0S0G7V0	Physiology	65bp indel in exon16 inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000003	ABCA2 A0A0S0G7V0	Physiology	5bp deletion inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00000004	ABCA2 A0A0S0G7V0	Physiology	5bp (GAATA) nucleotide duplication inducing a frameshift N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	ABCA2	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002054	ABCA2 A0A0S0G7V0	Physiology	insertion of a transposon Tntransib (2581 bp) in ABCA2 which changes splicing sites in the transcript and lead to an indel in the coding region: change of 1551VETLAHALGFLRHLDKR1567 into 1551AHWGK- LYGSNTQN1563 N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Tay WT; Mahon RJ; Heckel DG ; et al. (2015) Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]	GP00002056	ABCA2 A0A0S0G7V0	Physiology	14bp deletion resulting in missense mutations. N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D	ABCA2	Helicoverpa punctigera (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Candidate Gene	Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018) ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]	GP00002057	ABCA2 A0A0S0G7V0	Physiology	loss of exon 6 caused by alternative splicing N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	ABCA2	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
ABCA2	Xenobiotic resistance (insecticide; Bt Cry2Ab)	Coding, Insertion N	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Yang X; Chen W; Song X ; et al. (2019) Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.	GP00002467	ABCA2 Q9BZC7	Physiology	insertion of a 2581-bp transposon Tntransib in ABCA2. This insertion disrupts splicing sites and leads to indels in the protein sequence. CRISPR ABCA2 mutants are highly resistant to Cry2Ab. N	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCA2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCB1	Xenobiotic resistance (insecticide; Bt Cry3Aa toxin)	Coding, Deletion N	Chrysomela tremula (species) D	Intraspecific	Candidate Gene	Pauchet Y; Bretschneider A; Augustin S ; et al. (2016) A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle[...]	GP00002466	ABCB1 P08183	Physiology	a four-base-pair deletion at position 1561 introducing a frame shift with a premature stop codon leading to loss of the TpM1 transporter motif as well as the complete second transmembrane domain N	Chrysomela tremula (species)	Chrysomela tremula (species) D	ABCB1	Chrysomela tremula (species)	Published - Accepted by Curator
Abcb4	Biliary Phospholipid Level (low)	Coding, Unknown N	Cavia porcellus domestic guinea pig - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000008	Abcb4 P21440	Physiology	pseudogenization N	Mammalia mammals - (class)	Cavia porcellus domestic guinea pig - (species)	Abcb4	Cavia porcellus domestic guinea pig - (species)	Published - Accepted by Curator
Abcb4	Biliary Phospholipid Level (low)	Coding, Unknown N	Equus caballus horse - (species)	Intergeneric or Higher	Association Mapping	Hiller M; Schaar BT; Indjeian VB ; et al. (2012) A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]	GP00000009	Abcb4 P21440	Physiology	pseudogenization N	Mammalia mammals - (class)	Equus caballus horse - (species)	Abcb4	Equus caballus horse - (species)	Published - Accepted by Curator
ABCB4	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Bariami V; Jones CM; Poupardin R ; et al. (2012) Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]	GP00002607	Abcb4 P21440	Physiology	ABCB4 gene amplified about 6–7 times	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	ABCB4	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
ABCB7	Iron metabolism	Unknown, Unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Intraspecific	Association Mapping	Jones FC; Chan YF; Schmutz J ; et al. (2012) A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]	GP00001379	ABCB7 O75027	Physiology	unknown	Gasterosteus aculeatus three-spined stickleback - (species)	Gasterosteus aculeatus three-spined stickleback - (species)	ABCB7	Gasterosteus aculeatus three-spined stickleback - (species)	Published - Accepted by Curator
ABCC11	Apocrine secretion (ear wax type ; axillary odor)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Yoshiura K; Kinoshita A; Ishida T ; et al. (2006) A SNP in the ABCC11 gene is the determinant of human earwax type. 1 Additional References Martin A; Saathoff M; Kuhn F (2010) A functional ABCC11 allele is essential in the biochemical formation of human axillary odor.	GP00000010	ABCC11 Q96J66	Physiology	1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette	Homo sapiens human - (species)	Homo sapiens human - (species)	ABCC11	Homo sapiens human - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Insertion	Bombyx mori domestic silkworm - (species) D	Domesticated	Linkage Mapping	Atsumi S; Miyamoto K; Yamamoto K ; et al. (2012) Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin[...]	GP00000011	ABCC2 A0A0E3ZDK3	Physiology	1a.a. insertion at codon 234 (Tyr)	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	ABCC2	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Pauchet Y; Vogel H ; et al. (2010) An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]	GP00000012	ABCC2 A0A0E3ZDK3	Physiology	22bp deletion N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	ABCC2	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide)	Coding, Deletion N	Plutella xylostella diamondback moth - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000013	ABCC2 A0A0E3ZDK3	Physiology	30bp deletion N	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	ABCC2	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Unknown, Unknown	Trichoplusia ni cabbage looper - (species) D	Intraspecific	Linkage Mapping	Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011) Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.	GP00000014	ABCC2 A0A0E3ZDK3	Physiology	Not identified	Trichoplusia ni cabbage looper - (species)	Trichoplusia ni cabbage looper - (species) D	ABCC2	Trichoplusia ni cabbage looper - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Deletion N	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014) ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]	GP00001439		Physiology	About 500 nt genomic deletion over 2 exons involving 246 nt coding 82aa N	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D	ABCC2	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Banerjee R; Hasler J; Meagher R ; et al. (2017) Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm[...] 1 Additional References Flagel L; Lee YW; Wanjugi H (2018) Mutational disruption of the ABCC2 gene in fall armyworm, Spodoptera frugiperda, confers resistance [...]	GP00002461	MRP1 H8YF43	Physiology	A nine-base deletion (position 39–47) and a two-base insertion (GC at position 2218) lead to a frameshift and the occurrence of a premature stop codon. The truncated protein is 746 amino acids whereas the ABCC2 of the susceptible strain encodes a protein of 1349 amino acids. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D	ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABCC2	Xenobiotic resistance (insecticide; Bt toxins)	Coding, Complex Change N	Spodoptera frugiperda fall armyworm - (species) D	Intraspecific	Candidate Gene	Boaventura D; Ulrich J; Lueke B ; et al. (2020) Molecular characterization of Cry1F resistance in fall armyworm, Spodoptera frugiperda from Brazil.	GP00002462	MRP1 H8YF43	Physiology	two mutations in the extracellular loop 4 (ECL4) of ABCC2: a deletion of two amino acids (GY) at positions 788 and 789 and the change of a proline to either lysine or arginine at position 799. Expression of mutated ABCC2 in insect cells confirmed the role of these mutations in toxin binding. N	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species) D	ABCC2	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
ABCG2	Milk yield	Coding, SNP	Bos taurus cattle - (species)	Domesticated	Linkage Mapping	Cohen-Zinder M; Seroussi E; Larkin DM ; et al. (2005) Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chr[...] 1 Additional References Olsen HG; Nilsen H; Hayes B (2007) Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of [...]	GP00000015	Abcg2 Q7TMS5	Physiology	Tyr581Ser	Bos taurus cattle - (species)	Bos taurus cattle - (species)	ABCG2	Bos taurus cattle - (species)	Published - Accepted by Curator
ABCG2	Milk yield	Unknown, Unknown	Ovis aries sheep - (species)	Domesticated	Candidate Gene	García-Fernández M; Gutiérrez-Gil B; Sánchez JP ; et al. (2011) The role of bovine causal genes underlying dairy traits in Spanish Churra sheep.	GP00000016	Abcg2 Q7TMS5	Physiology	unknown	Ovis aries sheep - (species)	Ovis aries sheep - (species)	ABCG2	Ovis aries sheep - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000017	ABO P16442	Physiology	Gly268 (group A) <-> Ala (group B)	Homininae (subfamily)	Homininae (subfamily)	ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homininae (subfamily)	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Ségurel L; Thompson EE; Flutre T (2012) The ABO blood group is a trans-species polymorphism in primates.	GP00000018	ABO P16442	Physiology	Leu266 (group A) <-> Met (group B)	Homininae (subfamily)	Homininae (subfamily)	ABO histo blood group glycosyltransferase	Homininae (subfamily)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Deletion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Yamamoto F; Hakomori S (1990) Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...] 1 Additional References Calafell F; Roubinet F; Ramírez-Soriano A (2008) Evolutionary dynamics of the human ABO gene.	GP00000019	ABO P16442	Physiology	1bp deletion (258G) resulting in frameshift N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993) Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000020	ABO P16442	Physiology	Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function) two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.	Homo sapiens human - (species)	Homo sapiens human - (species)	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Insertion N	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000021	ABO P16442	Physiology	1bp insertion resulting in premature stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species) D	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, SNP N	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005) New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes. 1 Additional References Yazer MH; Hosseini-Maaf B; Olsson ML (2008) Blood grouping discrepancies between ABO genotype and phenotype caused by O alleles.	GP00000022	ABO P16442	Physiology	1bp change resulting in stop codon N	Homo sapiens human - (species)	Homo sapiens human - (species)	ABO histo blood group glycosyltransferase	Homo sapiens human - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Coding, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000023	ABO P16442	Physiology	Uncertain; possibly 9bp deletion resultin in 3a.a. deletion	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)	ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ABO histo blood group glycosyltransferase	ABO antigen blood type	Unknown, Unknown	Pan troglodytes chimpanzee - (species)	Intraspecific	Candidate Gene	Kermarrec N; Roubinet F; Apoil PA ; et al. (1999) Comparison of allele O sequences of the human and non-human primate ABO system.	GP00000024	ABO P16442	Physiology	unknown	Pan troglodytes chimpanzee - (species)	Pan troglodytes chimpanzee - (species)	ABO histo blood group glycosyltransferase	Pan troglodytes chimpanzee - (species)	Published - Accepted by Curator
ACD6 = ACCELERATED CELL DEATH 6	Plant size Pathogen resistance (plant microbes) Herbivore resistance	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Todesco M; Balasubramanian S; Hu TT ; et al. (2010) Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana. 1 Additional References Atwell S; Huang YS; Vilhjálmsson BJ (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.	GP00000025	ACD6 Q8LPS2	Physiology Physiology Physiology	Various	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	ACD6 = ACCELERATED CELL DEATH 6	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; cyclic ketoenol)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Lueke B; Douris V; Hopkinson JE ; et al. (2020) Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated[...] 1 Additional References Mavridis K; Papapostolou KM; Ilias A (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002513	ACC Q7JV23	Physiology	A2083V	Bemisia tabaci (species)	Bemisia tabaci (species) D	acetyl-CoA carboxylase (ACC)	Bemisia tabaci (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spiromesifen)	Coding, SNP	Trialeurodes vaporariorum greenhouse whitefly - (species) D	Intraspecific	Candidate Gene	Karatolos N; Williamson MS; Denholm I ; et al. (2012) Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid repla[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002556	ACC Q7JV23	Physiology	E645K	Trialeurodes vaporariorum greenhouse whitefly - (species)	Trialeurodes vaporariorum greenhouse whitefly - (species) D	acetyl-CoA carboxylase (ACC)	Trialeurodes vaporariorum greenhouse whitefly - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021) Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]	GP00002616	ACC Q7JV23	Physiology	a single non-synonymous mutation (gCt > gTt) resulting in an alanine to valine substitution in a highly conserved region of the ACC carboxyltransferase (CT) domain	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	acetyl-CoA carboxylase (ACC)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002617	ACC Q7JV23	Physiology	A1559V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)	Xenobiotic resistance (insecticide; spirotetramat)	Coding, SNP	Caenorhabditis elegans (species) D	Experimental Evolution	Linkage Mapping	Guest M; Kriek N; Flemming AJ (2020) Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.	GP00002618	ACC Q7JV23	Physiology	A1847V	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	acetyl-CoA carboxylase (ACC)	Caenorhabditis elegans (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles albimanus (species) D	Intraspecific	Candidate Gene	Weill M; Malcolm C; Chandre F ; et al. (2004) The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]	GP00000026	Ace P07140	Physiology	G119S	Anopheles albimanus (species)	Anopheles albimanus (species) D	Acetylcholinesterase (Ace-1)	Anopheles albimanus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000027	Ace P07140	Physiology	G119S	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000028	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Weill M; Lutfalla G; Mogensen K ; et al. (2003) Comparative genomics: Insecticide resistance in mosquito vectors.	GP00000029	Ace P07140	Physiology	Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00000030	Ace P07140	Physiology	F331W	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	Acetylcholinesterase (Ace-1)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex vishnui (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Cui F ; et al. (2007) Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]	GP00000031	Ace P07140	Physiology	G119S	Culex vishnui (species)	Culex vishnui (species) D	Acetylcholinesterase (Ace-1)	Culex vishnui (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	3 Mutations:	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Shang Q; Pan Y; Fang K ; et al. (2014) Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...] 4 Additional References Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Carletto J; Martin T; Vanlerberghe-Masutti F (2010) Insecticide resistance traits differ among and within host races in Aphis gossypii. Benting J; Nauen R (2004) Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates res[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00000036	Ace P07140	Physiology	3 mutations	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)	Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...] 1 Additional References Assogba BS; Djogbénou LS; Milesi P (2015) An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, [...]	GP00001372	Ace P07140	Physiology	Strict tandem duplication of 203kb encompassing 12 genes ; ace1 heterogeneous gene duplication (susceptible G119 and resistant S119 copies)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species)	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001373	Ace P07140	Physiology	Strict tandem 3 times duplication of 203kb encompassing 12 genes with partial internal deletion of 97kb in the third copy - ace1 homogeneous gene duplications (all 3 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species)	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Assogba BS; Milesi P; Djogbénou LS ; et al. (2016) The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]	GP00001374	Ace P07140	Physiology	Strict tandem 5 times duplication of 203kb encompassing 12 genes - ace1 homogeneous gene duplications (all 5 copies S119 resistant)	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	Acetylcholinesterase (Ace-1)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Nieuwenhuyse P; Demaeght P (2011) Acaricide resistance and resistance mechanisms in Tetranychus urticae populations from rose greenhou[...]	GP00002013	Ace P07140	Physiology	A201S	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Nabeshima T; Kozaki T; Tomita T ; et al. (2003) An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of[...]	GP00002015	Ace P07140	Physiology	Ser431Phe (position 331 in mature Torpedo protein)	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	Acetylcholinesterase (Ace-1)	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Chilo suppressalis striped riceborer - (species) D	Intraspecific	Candidate Gene	Jiang X; Qu M; Denholm I ; et al. (2009) Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]	GP00002453	Ace P07140	Physiology	an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance	Chilo suppressalis striped riceborer - (species)	Chilo suppressalis striped riceborer - (species) D	Acetylcholinesterase (Ace-1)	Chilo suppressalis striped riceborer - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Lee DW; Choi JY; Kim WT ; et al. (2007) Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.). 3 Additional References Yeh SC; Lin CL; Chang C (2014) Amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos [...] Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Zhang LJ; Jing YP; Li XH (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...]	GP00002454	Ace P07140	Physiology	2 mutations	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Mavridis K; Papapostolou KM; Ilias A ; et al. (2022) Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]	GP00002512	Ace P07140	Physiology	F331W	Bemisia tabaci (species)	Bemisia tabaci (species) D	Acetylcholinesterase (Ace-1)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002571	Ace P07140	Physiology	S119G	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 2 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Khajehali J; Van Leeuwen T; Grispou M (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...]	GP00002572	Ace P07140	Physiology	G328A	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Khajehali J; Van Leeuwen T; Grispou M ; et al. (2010) Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002573	Ace P07140	Physiology	F331W	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002574	Ace P07140	Physiology	D128E	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species)	Intraspecific	Candidate Gene	Li F; Han Z (2004) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 3 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods. Andrews MC; Callaghan A; Field LM (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis[...] Toda S; Komazaki S; Tomita T (2004) Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorou[...]	GP00002577	Ace P07140	Physiology	A201S	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species)	Acetylcholinesterase (Ace-1)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Cydia pomonella codling moth - (species) D	Intraspecific	Candidate Gene	Cassanelli S; Reyes M; Rault M ; et al. (2006) Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002580	Ace P07140	Physiology	F399V = F290V	Cydia pomonella codling moth - (species)	Cydia pomonella codling moth - (species) D	Acetylcholinesterase (Ace-1)	Cydia pomonella codling moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Alout H; Berthomieu A; Hadjivassilis A ; et al. (2007) A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipi[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002581	Ace P07140	Physiology	F290V	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Acetylcholinesterase (Ace-1)	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002587	Ace P07140	Physiology	S329(228)P	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Acetylcholinesterase (Ace-1)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002589	Ace P07140	Physiology	F330S	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012 ) Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002590	Ace P07140	Physiology	F331H	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	Acetylcholinesterase (Ace-1)	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus kanzawai (species) D	Intraspecific	Candidate Gene	Aiki Yasuhiko; Kozaki Toshinori; Mizuno Hiroshi ; et al. (2005 ) Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resist[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002591	Ace P07140	Physiology	F331W	Tetranychus kanzawai (species)	Tetranychus kanzawai (species) D	Acetylcholinesterase (Ace-1)	Tetranychus kanzawai (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002592	Ace P07140	Physiology	F331C	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus evansi red spider mite - (species) D	Intraspecific	Candidate Gene	Carvalho Renato; Yang Yihua; Field Linda M ; et al. (2012 ) Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002593	Ace P07140	Physiology	F331W/Y	Tetranychus evansi red spider mite - (species)	Tetranychus evansi red spider mite - (species) D	Acetylcholinesterase (Ace-1)	Tetranychus evansi red spider mite - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Zhang Yueliang; Li Shuo; Xu Lu ; et al. (2013 ) Overexpression of carboxylesterase-1 and mutation (F439H) of acetylcholinesterase-1 are associated w[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002594	Ace P07140	Physiology	F331H	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D	Acetylcholinesterase (Ace-1)	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002595	Ace P07140	Physiology	L336S	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D	Acetylcholinesterase (Ace-1)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-1)	Xenobiotic resistance (insecticide)	Coding, SNP	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Zhang LJ; Jing YP; Li XH ; et al. (2015) Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002598	Ace P07140	Physiology	A441G	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	Acetylcholinesterase (Ace-1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000040	Ace P07140	Physiology	Gly365Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000041	Ace P07140	Physiology	Gly262Val	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000043	Ace P07140	Physiology	Gly262Ala	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	4 Mutations: Coding SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. 2 Additional References Mutero A; Pralavorio M; Bride JM (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase. Menozzi P; Shi MA; Lougarre A (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002011	Ace P07140	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Mutero A; Pralavorio M; Bride JM ; et al. (1994) Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.	GP00002012	Ace P07140	Physiology	Ile199Thr (position 129 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002016	Ace P07140	Physiology	Gly368Ala (position 328 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes - GGC>GCC	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Anthony NM; Brown JK; Markham PG ; et al. (1995 ) Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002565	Ace P07140	Physiology	Phe392Trp mutation located in the acyl pocket of the active site gorge and recently shown to confer OP insensitivity in Culex tritaeniorhynchus	Bemisia tabaci (species)	Bemisia tabaci (species) D	Acetylcholinesterase (Ace-2)	Bemisia tabaci (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002568	Ace P07140	Physiology	E73G	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Aphis gossypii cotton aphid - (species) D	Intraspecific	Candidate Gene	Li Fei; Han Zhaojun (2004 ) Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002569	Ace P07140	Physiology	F78L	Aphis gossypii cotton aphid - (species)	Aphis gossypii cotton aphid - (species) D	Acetylcholinesterase (Ace-2)	Aphis gossypii cotton aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Menozzi P; Shi MA; Lougarre A ; et al. (2004) Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]	GP00002570	Ace P07140	Physiology	E81K	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Kozaki T; Shono T; Tomita T ; et al. (2001) Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002575	Ace P07140	Physiology	I129V	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002576	Ace P07140	Physiology	I129V	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Haematobia irritans horn fly - (species) D	Intraspecific	Candidate Gene	Temeyer KB; Li AY; Lohmeyer KH ; et al. (2008) Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae). 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002578	Ace P07140	Physiology	G227A	Haematobia irritans horn fly - (species)	Haematobia irritans horn fly - (species) D	Acetylcholinesterase (Ace-2)	Haematobia irritans horn fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002579	Ace P07140	Physiology	S238G	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace-2)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002582	Ace P07140	Physiology	F290Y	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace-2)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Cochliomyia hominivorax primary screw-worm - (species) D	Intraspecific	Candidate Gene	da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011) Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]	GP00002583	Ace P07140	Physiology	F466Y	Cochliomyia hominivorax primary screw-worm - (species)	Cochliomyia hominivorax primary screw-worm - (species) D	Acetylcholinesterase (Ace-2)	Cochliomyia hominivorax primary screw-worm - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002585	Ace P07140	Physiology	F368(290)L	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Intraspecific	Candidate Gene	Chen MH; Han ZJ; Qiao XF ; et al. (2007) Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002586	Ace P07140	Physiology	V435(356)A	Rhopalosiphum padi bird cherry-oat aphid - (species)	Rhopalosiphum padi bird cherry-oat aphid - (species) D	Acetylcholinesterase (Ace-2)	Rhopalosiphum padi bird cherry-oat aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Ceratitis capitata Mediterranean fruit fly - (species) D	Intraspecific	Candidate Gene	Magaña C; Hernández-Crespo P; Brun-Barale A ; et al. (2008) Mechanisms of resistance to malathion in the medfly Ceratitis capitata. 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002588	Ace P07140	Physiology	Gly328Ala	Ceratitis capitata Mediterranean fruit fly - (species)	Ceratitis capitata Mediterranean fruit fly - (species) D	Acetylcholinesterase (Ace-2)	Ceratitis capitata Mediterranean fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Culex tritaeniorhynchus (species) D	Intraspecific	Candidate Gene	Nabeshima T; Mori A; Kozaki T ; et al. (2004) An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Ja[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002596	Ace P07140	Physiology	F331W - F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge	Culex tritaeniorhynchus (species)	Culex tritaeniorhynchus (species) D	Acetylcholinesterase (Ace-2)	Culex tritaeniorhynchus (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace-2)	Xenobiotic resistance (insecticide)	Coding, SNP	Sitobion avenae English grain aphid - (species) D	Intraspecific	Candidate Gene	Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007 ) Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...] 1 Additional References Feyereisen R; Dermauw W; Van Leeuwen T (2015) Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods.	GP00002597	Ace P07140	Physiology	W435R	Sitobion avenae English grain aphid - (species)	Sitobion avenae English grain aphid - (species) D	Acetylcholinesterase (Ace-2)	Sitobion avenae English grain aphid - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002) Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]	GP00000037	Ace P07140	Physiology	2 mutations	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, Deletion	Bactrocera oleae olive fruit fly - (species) D	Intraspecific	Candidate Gene	Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008) A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...] 1 Additional References Kakani EG; Bon S; Massoulié J (2011) Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides.	GP00000038	Ace P07140	Physiology	9bp deletion of three glutamine residues at positions 642_644	Bactrocera oleae olive fruit fly - (species)	Bactrocera oleae olive fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera oleae olive fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00000039	Ace P07140	Physiology	Ser->Gly at position 238 of the Torpedo AChE	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000042	Ace P07140	Physiology	Val180Leu	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Walsh SB; Dolden TA; Moores GD ; et al. (2001) Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]	GP00000044	Ace P07140	Physiology	Phe327Tyr	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	Acetylcholinesterase (Ace)	Musca domestica house fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	2 Mutations: Coding SNP	Bactrocera dorsalis oriental fruit fly - (species) D	Intraspecific	Candidate Gene	Hsu JC; Haymer DS; Wu WJ ; et al. (2006) Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]	GP00000045	Ace P07140	Physiology	2 mutations	Bactrocera dorsalis oriental fruit fly - (species)	Bactrocera dorsalis oriental fruit fly - (species) D	Acetylcholinesterase (Ace)	Bactrocera dorsalis oriental fruit fly - (species)	Published - Accepted by Curator
Acetylcholinesterase (Ace)	Xenobiotic resistance (insecticide)	Coding, SNP	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Intraspecific	Candidate Gene	Zhu KY; Lee SH; Clark JM (1996) A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]	GP00002014	Ace P07140	Physiology	Ser>Gly (238 is the corresponding position in Torpedo)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Leptinotarsa decemlineata Colorado potato beetle - (species) D	Acetylcholinesterase (Ace)	Leptinotarsa decemlineata Colorado potato beetle - (species)	Published - Accepted by Curator
adenosine deaminase (AgADA)	Pathogen resistance (parasite)	Coding, SNP	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Association Mapping	Li J; Wang X; Zhang G ; et al. (2013) Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]	GP00001463	ADA P00813	Physiology	c.C427T p.R143C	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	adenosine deaminase (AgADA)	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
AEP2	Hybrid Incompatibility (F2 sterility)	Coding, SNP	Saccharomyces bayanus (species)	Domesticated	Linkage Mapping	Lee HY; Chou JY; Cheong L ; et al. (2008) Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast speci[...]	GP00000051	AEP2 P22136	Physiology	The region between aa 348 and aa 496 plays a critical role. When this region was further dissected in the constructs H-AEP2-bcb and H-AEP2-m3; both failed to restore respiration in the Chromosome 13 line. This result suggests that multiple critical mutations have occurred during the functional diversification of Sc-AEP2 and Sb-AEP2. Exact causing mutation(s) not determined	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)	AEP2	Saccharomyces bayanus (species)	Published - Accepted by Curator
AFGP multigene - antifreeze glycoproteins	Anti-freezing	Coding, Unknown	Dissostichus mawsoni Antarctic toothfish - (species)	Intergeneric or Higher	Candidate Gene	Chen L; DeVries AL; Cheng CH (1997) Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. 2 Additional References Cheng CC; Cziko PA; Evans CW (2006) Nonhepatic origin of notothenioid antifreeze reveals pancreatic synthesis as common mechanism in pol[...] Near TJ; Dornburg A; Kuhn KL (2012) Ancient climate change, antifreeze, and the evolutionary diversification of Antarctic fishes.	GP00000052	afgp8 P24856	Physiology	multiple modifications of a pancreatic; secreted trypsinogen; notably via multiplications of small tri-peptidic repeats	Teleostei teleost fishes - (infraclass)	Dissostichus mawsoni Antarctic toothfish - (species)	AFGP multigene - antifreeze glycoproteins	Dissostichus mawsoni Antarctic toothfish - (species)	Published - Accepted by Curator
Agouti (ASIP)	Coloration (coat) Lifespan	2 Mutations: Coding N	Ovis aries sheep - (species) D	Intraspecific	Linkage Mapping	Gratten J; Pilkington JG; Brown EA ; et al. (2010) The genetic basis of recessive self-colour pattern in a wild sheep population. 1 Additional References Gratten J; Pilkington JG; Brown EA (2012) Selection and microevolution of coat pattern are cryptic in a wild population of sheep.	GP00001356	Asip Q03288	Morphology Physiology	2 mutations	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	Agouti (ASIP)	Ovis aries sheep - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (polycyclic aromatic hydrocarbons; TCDD)	Coding, SNP	Mus musculus house mouse - (species)	Domesticated	Linkage Mapping	Poland A; Palen D; Glover E (1994) Analysis of the four alleles of the murine aryl hydrocarbon receptor.	GP00001810	Ahr P30561	Physiology	alanine at position 375 mutated into valine; decreases the affinity 4-fold	Mus musculus house mouse - (species)	Mus musculus house mouse - (species)	AHR	Mus musculus house mouse - (species)	Published - Accepted by Curator
AHR	Xenobiotic resistance (dioxins; polycyclic aromatic hydrocarbons; TCDD)	2 Mutations: Coding SNP	Sterna hirundo hirundo (subspecies) D	Intergeneric or Higher	Candidate Gene	Karchner SI; Franks DG; Kennedy SW ; et al. (2006) The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon recep[...] 1 Additional References Head JA; Hahn ME; Kennedy SW (2008) Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species.	GP00001811	Ahr P30561	Physiology	2 mutations	Gallus gallus chicken - (species)	Sterna hirundo hirundo (subspecies) D	AHR	Sterna hirundo hirundo (subspecies)	Published - Accepted by Curator
AHR	Xenobiotic resistance (TCDD)	Coding, SNP N	Rattus norvegicus Norway rat - (species) D	Intraspecific	Linkage Mapping	Tuomisto JT; Viluksela M; Pohjanvirta R ; et al. (1999) The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resista[...] 2 Additional References Moffat ID; Roblin S; Harper PA (2007) Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transac[...] Pohjanvirta R; Wong JM; Li W (1998) Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon[...]	GP00001813	Ahr P30561	Physiology	point mutation in the exon/intron 10 boundary in AHR genomic structure that leads to use of 3 alternative cryptic splice sites; potentially creating 3 alternative transcripts and 2 protein products. At the protein level the mutation leads to a total loss of either 43 or 38 amino acids (with altered sequence for the last seven amino acids in the latter case) toward the carboxyl-terminal end in the trans-activation domain of the AhR. H/W rats also harbor a point mutation in exon 10 that will cause a Val-to-Ala substitution in codon 497, but this occurs in a variable region of the AhR N	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D	AHR	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001806	Ahr P30561	Physiology	70 kb deletion that removes parts of the two genes AHR1a and AHR2a N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001807	Ahr P30561	Physiology	45 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 5 of AHR2a to exon 4 of AHR1a) N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution)	Gene Loss, Deletion N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. 1 Additional References Clark BW; Matson CW; Jung D (2010) AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic kill[...]	GP00001808	Ahr P30561	Physiology	83 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 11 of AHR2a to exon 6 of AHR1a) N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AHR2	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
AHR2	Xenobiotic resistance (pollution; polychlorinated biphenyls; PCBs)	Coding, Deletion N	Microgadus tomcod Atlantic tomcod - (species) D	Intraspecific	Candidate Gene	Wirgin I; Roy NK; Loftus M ; et al. (2011) Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.	GP00001809	Ahr P30561	Physiology	6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain N	Microgadus tomcod Atlantic tomcod - (species)	Microgadus tomcod Atlantic tomcod - (species) D	AHR2	Microgadus tomcod Atlantic tomcod - (species)	Published - Accepted by Curator
AIM22	F2 lethality	Coding, SNP	Saccharomyces bayanus (species)	Interspecific	Linkage Mapping	Chou JY; Hung YS; Lin KH ; et al. (2010) Multiple molecular mechanisms cause reproductive isolation between three yeast species.	GP00000073	AIM22 P47051	Physiology	Several candidate non-synonymous changes - exact causing mutation(s) unknown	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces bayanus (species)	AIM22	Saccharomyces bayanus (species)	Published - Accepted by Curator
AIP	Xenobiotic resistance (pollution)	Unknown, Unknown N	Fundulus heteroclitus mummichog - (species) D	Intraspecific	Association Mapping	Reid NM; Proestou DA; Clark BW ; et al. (2016) The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.	GP00001812	Aip O08915	Physiology	exact mutation(s) unknown - very good candidate gene according to association mapping and knowledge about the physiology N	Fundulus heteroclitus mummichog - (species)	Fundulus heteroclitus mummichog - (species) D	AIP	Fundulus heteroclitus mummichog - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	6 Mutations:	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Choudhary M; Laurie CC (1991) Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...] 4 Additional References Laurie CC; Bridgham JT; Choudhary M (1991) Associations between DNA sequence variation and variation in expression of the Adh gene in natural p[...] King EG; Merkes CM; McNeil CL (2012) Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource. Siddiq MA; Loehlin DW; Montooth KL (2017) Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaste[...] Loehlin DW; Ames JR; Vaccaro K (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001962	Adh P00334	Physiology	6 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila yakuba (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001963	Adh P00334	Physiology	4 mutations	Drosophila santomea (species)	Drosophila yakuba (species)	alcohol dehydrogenase (Adh)	Drosophila yakuba (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	4 Mutations:	Drosophila erecta (species)	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001964	Adh P00334	Physiology	4 mutations	Drosophila orena (species)	Drosophila erecta (species)	alcohol dehydrogenase (Adh)	Drosophila erecta (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	5 Mutations:	Drosophila virilis (species) D	Interspecific	Candidate Gene	Loehlin DW; Ames JR; Vaccaro K ; et al. (2019) A major role for noncoding regulatory mutations in the evolution of enzyme activity.	GP00001965	Adh P00334	Physiology	5 mutations	Drosophila americana (species)	Drosophila virilis (species) D	alcohol dehydrogenase (Adh)	Drosophila virilis (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Unknown	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Vigue C; Sofer W (1974) Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.	GP00001988	Adh P00334	Physiology	Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Strand DJ; McDonald JF (1989) Insertion of a copia element 5' to the Drosophila melanogaster alcohol dehydrogenase gene (adh) is a[...]	GP00001989	Adh P00334	Physiology	insertion of a complete 5.2kb copia retroviral-like transposable element 240 bp upstream from the distal (adult) adh transcriptional start site	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Insertion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Freeth AL; Gibson JB; Wilks AV (1990) Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...] 1 Additional References Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001990	Adh P00334	Physiology	eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (Adh)	Xenobiotic resistance (alcohol)	Coding, Deletion N	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Gibson JB; Wilks AV; Agrotis A (1992) Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]	GP00001991	Adh P00334	Physiology	438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	alcohol dehydrogenase (Adh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)	Xenobiotic resistance (alcohol)	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Association Mapping	Li H; Mukherjee N; Soundararajan U ; et al. (2007) Geographically separate increases in the frequency of the derived ADH1B47His allele in eastern and [...] 1 Additional References Li H; Mukherjee N; Soundararajan U (2007)* Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]	GP00000077	ADH1B P00325	Physiology	Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication	Homo sapiens human - (species)	Homo sapiens human - (species) D	alcohol dehydrogenase (ADH1B)	Homo sapiens human - (species)	Published - Accepted by Curator
Aldehyde dehydrogenase (Aldh)	Xenobiotic resistance (alcohol)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Fry JD; Donlon K; Saweikis M (2008) A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selectio[...]	GP00002007	Aldh Q9VLC5	Physiology	L479F C9391311T	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Aldehyde dehydrogenase (Aldh)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Alk / Starch Synthase II	Grain cooking texture	4 Mutations: Coding SNP	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Umemoto T; Yano M; Satoh H ; et al. (2002) Mapping of a gene responsible for the difference in amylopectin structure between japonica-type and [...] 2 Additional References Nakamura Y; Francisco PB; Hosaka Y (2005) Essential amino acids of starch synthase IIa differentiate amylopectin structure and starch quality [...] Huang X; Wei X; Sang T (2010) Genome-wide association studies of 14 agronomic traits in rice landraces.	GP00000078	SSII-3 Q0DDE3	Physiology	4 mutations	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	Alk / Starch Synthase II	Oryza sativa rice - (species)	Published - Accepted by Curator
Allantoin permease DAL4	Nitrogen use (growth rate on allantoin)	Coding, Indel N	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001503	DAL4 Q04895	Physiology	c.1201delA a single nucleotide frameshifting insertion (deletion?) N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Allantoin permease DAL4	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Allantoinase DAL1	Nitrogen use (growth rate on allantoin)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Intraspecific	Linkage Mapping	Ibstedt S; Stenberg S; Bagés S ; et al. (2015) Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.	GP00001502	DAL1 P32375	Physiology	c.415C>T p.P139S predicted to be strongly detrimental	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Allantoinase DAL1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
ALMT gene cluster	Metal tolerance	Gene Amplification, Indel	Secale cereale rye - (species)	Domesticated	Linkage Mapping	Collins NC; Shirley NJ; Saeed M ; et al. (2008) An ALMT1 gene cluster controlling aluminum tolerance at the Alt4 locus of rye (Secale cereale L).	GP00000079	ALMT1 Q76LB1	Physiology	Copy number Variant	Secale cereale rye - (species)	Secale cereale rye - (species)	ALMT gene cluster	Secale cereale rye - (species)	Published - Accepted by Curator
ALMT1	Metal tolerance	Cis-regulatory, Unknown	Triticum aestivum bread wheat - (species)	Domesticated	Linkage Mapping	Raman H; Zhang K; Cakir M ; et al. (2005) Molecular characterization and mapping of ALMT1, the aluminium-tolerance gene of bread wheat (Tritic[...] 2 Additional References Cai S; Bai GH; Zhang D (2008) Quantitative trait loci for aluminum resistance in Chinese wheat landrace FSW. Ryan PR; Raman H; Gupta S (2010) The multiple origins of aluminium resistance in hexaploid wheat include Aegilops tauschii and more r[...]	GP00000080	ALMT1 Q76LB1	Physiology	multiple regulatory changes	Triticum aestivum bread wheat - (species)	Triticum aestivum bread wheat - (species)	ALMT1	Triticum aestivum bread wheat - (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001893	ALS P17597	Physiology	W574L	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D	ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001894	ALS P17597	Physiology	S653N	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D	ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ALS	Xenobiotic resistance (herbicides; ALS inhibitor)	Coding, SNP	Amaranthus tuberculatus (species) D	Intraspecific	Linkage Mapping	Patzoldt William L; Tranel Patrick J (2007 ) Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)	GP00001895	ALS P17597	Physiology	S653T	Amaranthus tuberculatus (species)	Amaranthus tuberculatus (species) D	ALS	Amaranthus tuberculatus (species)	Published - Accepted by Curator
ameloblastin (AMBN)	Tooth absence (no enamel production)	Gene Loss, Deletion N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001934	AMBN Q9NP70	Physiology	synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	ameloblastin (AMBN)	Gallus gallus chicken - (species)	Published - Accepted by Curator
ameloblastin (AMBN)	Tooth absence (no enamel production)	Coding, Unknown N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Deméré TA; McGowen MR; Berta A ; et al. (2008) Morphological and molecular evidence for a stepwise evolutionary transition from teeth to baleen in [...] 1 Additional References Meredith RW; Gatesy J; Cheng J (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001938	AMBN Q9NP70	Physiology	multiple frameshift mutations N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D	ameloblastin (AMBN)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
amelogenin (AMEL)	Tooth absence (no enamel production)	3 Mutations: Coding N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001933	Amelx P63277	Physiology	3 mutations	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	amelogenin (AMEL)	Gallus gallus chicken - (species)	Published - Accepted by Curator
amelogenin (AMEL)	Tooth absence (no enamel production)	Coding, Unknown N	Mysticeti baleen whales - (suborder) D	Intergeneric or Higher	Candidate Gene	Meredith RW; Gatesy J; Cheng J ; et al. (2011) Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]	GP00001937	Amelx P63277	Physiology	J. Gatesy 2010 unpublished data cited in the main reference N	Cetacea whales - (order)	Mysticeti baleen whales - (suborder) D	amelogenin (AMEL)	Mysticeti baleen whales - (suborder)	Published - Accepted by Curator
Amhr2	Sex determination (female vs male)	Coding, SNP	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Intraspecific	Linkage Mapping	Kamiya T; Kai W; Tasumi S ; et al. (2012) A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, [...]	GP00002147	AMHR2 Q16671	Physiology	His/Asp384 heterozygous males have reduced Amrh2 activity due to decreased activity of the kinase signaling domain	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Amhr2	Takifugu rubripes torafugu - (species) Takifugu poecilonotus finepatterned puffer - (species) Takifugu pardalis panther puffer - (species)	Published - Accepted by Curator
Aminopeptidase N (APN)	Xenobiotic resistance (insecticide; Bt Cry2Ac toxin)	Coding, Deletion N	Helicoverpa armigera cotton bollworm - (species) D	Experimental Evolution	Candidate Gene	Yang Y; Zhu YC; Ottea J ; et al. (2010) Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacil[...]	GP00002463	apn Q9VFX3	Physiology	deletion removing 22 amino acids. The mutant form failed to bind Cry1Ac unlike the full-length susceptible form. N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	Aminopeptidase N (APN)	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
ammonium transporter 2;1	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001431	AMT2 Q9M6N7	Physiology	seven aa substitutions	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D	ammonium transporter 2;1	Arabidopsis arenosa (species)	Published - Accepted by Curator
AMN1	Cell separation	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Yvert G; Brem RB; Whittle J ; et al. (2003) Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.	GP00000082	AMN1 P38285	Physiology	D368V	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	AMN1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
AMPD1 (=CG32626)	Drug resistance	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Kislukhin G; King EG; Walters KN ; et al. (2013) The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.	GP00000083	AMPD1 P23109	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	AMPD1 (=CG32626)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]	Drug resistance	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Candidate Gene	Wessels JA; van der Kooij SM; le Cessie S ; et al. (2007) A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset[...]	GP00000084	AMPD1 P23109	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]	Homo sapiens human - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Mus musculus house mouse - (species) D	Domesticated	Candidate Gene	Pajic P; Pavlidis P; Dean K ; et al. (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00001867	Amy1 P00687	Physiology	Copy Number Variation	Mus musculus house mouse - (species)	Mus musculus house mouse - (species) D	amylase	Mus musculus house mouse - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Rattus norvegicus Norway rat - (species) D	Domesticated	Candidate Gene	Pajic P; Pavlidis P; Dean K ; et al. (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00001868	Amy1 P00687	Physiology	Copy Number Variation	Rattus norvegicus Norway rat - (species)	Rattus norvegicus Norway rat - (species) D	amylase	Rattus norvegicus Norway rat - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Sus scrofa pig - (species) D	Domesticated	Candidate Gene	Pajic P; Pavlidis P; Dean K ; et al. (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00001869	Amy1 P00687	Physiology	Copy Number Variation	Sus scrofa pig - (species)	Sus scrofa pig - (species) D	amylase	Sus scrofa pig - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Cebus capucinus white-faced sapajou - (species) D	Intergeneric or Higher	Candidate Gene	Pajic P; Pavlidis P; Dean K ; et al. (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00001870	Amy1 P00687	Physiology	3-4 copies of the amylase gene; which coincides with increased levels of amylase activity in saliva	Aotus trivirgatus douroucouli - (species) Callithrix jacchus white-tufted-ear marmoset - (species)	Cebus capucinus white-faced sapajou - (species) D	amylase	Cebus capucinus white-faced sapajou - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Papio anubis olive baboon - (species) D	Intergeneric or Higher	Candidate Gene	Pajic P; Pavlidis P; Dean K ; et al. (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00001871	Amy1 P00687	Physiology	3-4 copies of the amylase gene; which coincides with increased levels of amylase activity in saliva	Cercocebus atys sooty mangabey - (species) Macaca mulatta Rhesus monkey - (species)	Papio anubis olive baboon - (species) D	amylase	Papio anubis olive baboon - (species)	Published - Accepted by Curator
amylase	Starch processing	Gene Amplification, Insertion	Meles leucurus Asian badger - (species) D	Intraspecific	Candidate Gene	Abduriyim Shamshidin; Nishita Yoshinori; Abramov AV ; et al. (2019 ) Variation in pancreatic amylase gene copy number among Eurasian badgers (Carnivora, Mustelidae, Mele[...]	GP00001907	Amy1 P00687	Physiology	Copy Number Variation varies between one and four in this species	Meles leucurus Asian badger - (species)	Meles leucurus Asian badger - (species) D	amylase	Meles leucurus Asian badger - (species)	Published - Accepted by Curator
amylase 1 (AMY1)	Starch processing	Gene Amplification, Insertion	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Perry GH; Dominy NJ; Claw KG ; et al. (2007) Diet and the evolution of human amylase gene copy number variation. 2 Additional References Falchi M; El-Sayed Moustafa JS; Takousis P (2014) Low copy number of the salivary amylase gene predisposes to obesity. Pajic P; Pavlidis P; Dean K (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00000085	AMY1A P04745	Physiology	Probably gene duplication	Homo sapiens human - (species)	Homo sapiens human - (species) D	amylase 1 (AMY1)	Homo sapiens human - (species)	Published - Accepted by Curator
amylase 2B (AMY2B)	Starch processing	Gene Amplification, Insertion	Canis lupus familiaris dog - (subspecies) D	Domesticated	Association Mapping	Axelsson E; Ratnakumar A; Arendt ML ; et al. (2013) The genomic signature of dog domestication reveals adaptation to a starch-rich diet. 4 Additional References Arendt M; Cairns KM; Ballard JW (2016) Diet adaptation in dog reflects spread of prehistoric agriculture. Arendt M; Fall T; Lindblad-Toh K (2014) Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, d[...] Tonoike A; Hori Y; Inoue-Murayama M (2015) Copy number variations in the amylase gene (AMY2B) in Japanese native dog breeds. Pajic P; Pavlidis P; Dean K (2019) Independent amylase gene copy number bursts correlate with dietary preferences in mammals.	GP00000086	LOC479922 L7N0N6	Physiology	Copy Number Variation	Canis lupus gray wolf - (species)	Canis lupus familiaris dog - (subspecies) D	amylase 2B (AMY2B)	Canis lupus familiaris dog - (subspecies)	Published - Accepted by Curator
AOP2	Glucosinolate content	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000095	AOP2 Q945B5	Physiology	5bp deletion resulting in frameshift N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AOP2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AOP3	Glucosinolate content	Coding, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001) Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...] 2 Additional References Chan EK; Rowe HC; Kliebenstein DJ (2010) Understanding the evolution of defense metabolites in Arabidopsis thaliana using genome-wide associa[...] Chan EK; Rowe HC; Corwin JA (2011) Combining genome-wide association mapping and transcriptional networks to identify novel genes contr[...]	GP00000096	AOP3 Q9ZTA1	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AOP3	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
apicoplast ribosomal protein S10	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001531	PF3D7_1460900.1 Q8IKM3	Physiology	p.Val127Met	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D	apicoplast ribosomal protein S10	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
APJ1	Xenobiotic resistance (alcohol, ethanol)	Cis-regulatory, Unknown	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Swinnen S; Schaerlaekens K; Pais T ; et al. (2012) Identification of novel causative genes determining the complex trait of high ethanol tolerance in y[...]	GP00000097	APJ1 P53940	Physiology	unknown	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	APJ1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
APL1 cluster	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Anopheles gambiae African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Riehle MM; Markianos K; Niaré O ; et al. (2006) Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. 1 Additional References Rottschaefer SM; Riehle MM; Coulibaly B (2011) Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 mal[...]	GP00000098	APL1A L7RQU1	Physiology	Not identified	Anopheles gambiae African malaria mosquito - (species)	Anopheles gambiae African malaria mosquito - (species) D	APL1 cluster	Anopheles gambiae African malaria mosquito - (species)	Published - Accepted by Curator
APOE (apolipoprotein E)	Aging	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000099	APOE P02649	Physiology	Cys112Arg	Homo sapiens human - (species)	Homo sapiens human - (species)	APOE (apolipoprotein E)	Homo sapiens human - (species)	Published - Accepted by Curator
APSR	Sulfate content (shoot)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007) Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.	GP00000100	APR2 P92981	Physiology	A399E N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	APSR	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Aquaporin	Water transport (selective accumulation of water or glycerol)	Coding, SNP	Polypedilum vanderplanki sleeping chironomid - (species)	Interspecific	Candidate Gene	Finn RN; Chauvigné F; Stavang JA ; et al. (2015) Insect glycerol transporters evolved by functional co-option and gene replacement.	GP00001421	AQP1 P29972	Physiology	p.His174Ala	Blattella germanica German cockroach - (species)	Polypedilum vanderplanki sleeping chironomid - (species)	Aquaporin	Polypedilum vanderplanki sleeping chironomid - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	2 Mutations: Coding SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001872	AQP1 P29972	Physiology	2 mutations	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001873	AQP1 P29972	Physiology	aquaporin yeast 1 gene on chromosome 12 - A881 deletion renders AQY1 inactive - size of the deletion not indicated in the paper - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY1)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Bonhivers M; Carbrey JM; Gould SJ (1998) Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type st[...]	GP00001874	AQP1 P29972	Physiology	aquaporin yeast 1 gene on chromosome 12 - 955-bp deletion that removes the first 106 bp of AQY1 and its upstream region - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY1)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Linkage Mapping	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Carbrey JM; Bonhivers M; Boeke JD (2001) Aquaporins in Saccharomyces: Characterization of a second functional water channel protein.	GP00001875	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - 11-bp deletion that creates a stop codon in the middle of the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...] 1 Additional References Laizé V; Tacnet F; Ripoche P (2000) Polymorphism of Saccharomyces cerevisiae aquaporins.	GP00001876	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - deletion of nucleotide G at position 25 (G25) which creates a frameshift the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
Aquaporin (AQY2)	Growth rate (environment-dependent)	Coding, Deletion N	Saccharomyces cerevisiae baker's yeast - (species) D	Domesticated	Candidate Gene	Will JL; Kim HS; Clarke J ; et al. (2010) Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]	GP00001877	AQP1 P29972	Physiology	aquaporin yeast 2 gene on chromosome 11 - G528 deletion which creates a frameshift the AQY2 gene - tested in assays - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	Aquaporin (AQY2)	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
arginyl-transfer RNA synthetase (RARS)	Heat tolerance	Coding, SNP	Anolis cristatellus (species) D	Intraspecific	Association Mapping	Campbell-Staton SC; Winchell KM; Rochette NC ; et al. (2020) Parallel selection on thermal physiology facilitates repeated adaptation of city lizards to urban he[...]	GP00002620	RARS2 Q5T160	Physiology	C>G threonine>serine at amino acid residue 558 of the RARS gene = adjacent to a predicted protein-binding region22 (AA556–557). There are four non-synonymous polymorphic sites within RARS. Only one shows a significant difference in allele frequency between forest and urban habitats across all populations.	Anolis cristatellus (species)	Anolis cristatellus (species) D	arginyl-transfer RNA synthetase (RARS)	Anolis cristatellus (species)	Published - Accepted by Curator
ARHGAP15	Pathogen resistance (Trypanosoma)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Noyes H; Brass A; Obara I ; et al. (2011) Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]	GP00000103	Arhgap15 Q811M1	Physiology	H282P	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	ARHGAP15	Bos taurus cattle - (species)	Published - Accepted by Curator
ARHGEF3	Hematopoiesis (mean blood platelet volume & blood platelet count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001605	ARHGEF3 Q9NR81	Physiology	T>C at the associated SNP that disrupts a conserved GATA motif. This variant overlaps with a common-myeloid progenitor (CMP-) and megakaryocyte-erythroid progenitor (MEP-) specific regulatory element that affects the transcription of ARHGEF3	Homo sapiens human - (species)	Homo sapiens human - (species)	ARHGEF3	Homo sapiens human - (species)	Published - Accepted by Curator
ASP1	Acetic acid production	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Marullo P; Aigle M; Bely M ; et al. (2007) Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cere[...]	GP00000104	APS1 P35181	Physiology	Asp142His	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	ASP1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
asparagine synthetase (AS)	Silk yield	Unknown, Unknown	Bombyx mori domestic silkworm - (species) D	Domesticated	Association Mapping	Xiang H; Liu X; Li M ; et al. (2018) The evolutionary road from wild moth to domestic silkworm. 1 Additional References Tong X; Han MJ; Lu K (2022) High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]	GP00002404	AsnS Q7KTW9	Physiology		Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	asparagine synthetase (AS)	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
AT5G41740/AT5G41750	Hybrid incompatibility (auto-immune necrosis)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Bomblies K; Lempe J; Epple P ; et al. (2007) Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants.	GP00000105	MUF8.2 F4JYI4	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AT5G41740/AT5G41750	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtHKT1	Salt tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Rus A; Baxter I; Muthukumar B ; et al. (2006) Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. 1 Additional References Baxter I; Brazelton JN; Yu D (2010) A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the[...]	GP00000124	HKT1 Q84TI7	Physiology	725bp deletion of part of upstream repeat region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtHKT1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtHKT1	Salt tolerance	Cis-regulatory, Deletion	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Rus A; Baxter I; Muthukumar B ; et al. (2006) Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. 1 Additional References Baxter I; Brazelton JN; Yu D (2010) A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the[...]	GP00000125	HKT1 Q84TI7	Physiology	687bp deletion of part of upstream repeat region	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	AtHKT1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
AtLURE1	Fertilization (pollen-tube attraction by egg)	Gene Amplification, Complex Change	Arabidopsis thaliana thale cress - (species)	Interspecific	Candidate Gene	Takeuchi H; Higashiyama T (2012) A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arab[...]	GP00000126	LURE1.1 Q4VP09	Physiology	Gene birth	Arabidopsis lyrata (species)	Arabidopsis thaliana thale cress - (species)	AtLURE1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
ATP2B4	Pathogen resistance (Plasmodium; malaria parasite)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Timmann C; Thye T; Vens M ; et al. (2012) Genome-wide association study indicates two novel resistance loci for severe malaria.	GP00000127	ATP2B4 P23634	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	ATP2B4	Homo sapiens human - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001908	ATP4A P20648	Physiology	Absence of the gene in the genome sequence N	Monodelphis domestica gray short-tailed opossum - (species)	Ornithorhynchus anatinus platypus - (species) D	ATP4A	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001920	ATP4A P20648	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species) Oreochromis niloticus Nile tilapia - (species)	Danio rerio zebrafish - (species) D	ATP4A	Danio rerio zebrafish - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001922	ATP4A P20648	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	ATP4A	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
ATP4A	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001928	ATP4A P20648	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	ATP4A	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	3 Mutations: Coding N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001909	ATP4B P51164	Physiology	3 mutations	Monodelphis domestica gray short-tailed opossum - (species) Homo sapiens human - (species)	Ornithorhynchus anatinus platypus - (species) D	ATP4B	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Callorhinchus milii elephant shark - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001916	ATP4B P51164	Physiology	Absence of the gene in the genome sequence N	Scyliorhinus canicula smaller spotted catshark - (species)	Callorhinchus milii elephant shark - (species) D	ATP4B	Callorhinchus milii elephant shark - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Danio rerio zebrafish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001921	ATP4B P51164	Physiology	Absence of the gene in the genome sequence - high synteny N	Gadus morhua Atlantic cod - (species) Gasterosteus aculeatus three-spined stickleback - (species) Oreochromis niloticus Nile tilapia - (species)	Danio rerio zebrafish - (species) D	ATP4B	Danio rerio zebrafish - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001923	ATP4B P51164	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species)	Oryzias latipes Japanese medaka - (species) D Xiphophorus maculatus southern platyfish - (species) D	ATP4B	Oryzias latipes Japanese medaka - (species) Xiphophorus maculatus southern platyfish - (species)	Published - Accepted by Curator
ATP4B	Digestion (absence of stomach)	Gene Loss, Deletion N	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	Intergeneric or Higher	Candidate Gene	Castro LF; Gonçalves O; Mazan S ; et al. (2014) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.	GP00001929	ATP4B P51164	Physiology	Absence of the gene in the genome sequence - high synteny N	Oreochromis niloticus Nile tilapia - (species) Gasterosteus aculeatus three-spined stickleback - (species)	Takifugu rubripes torafugu - (species) D Tetraodon nigroviridis spotted green pufferfish - (species) D	ATP4B	Takifugu rubripes torafugu - (species) Tetraodon nigroviridis spotted green pufferfish - (species)	Published - Accepted by Curator
ATR13	Pathogenicity	Coding, SNP	Hyaloperonospora parasitica (species)	Intraspecific	Linkage Mapping	Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004) Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. 1 Additional References Allen RL; Meitz JC; Baumber RE (2008) Natural variation reveals key amino acids in a downy mildew effector that alters recognition specifi[...]	GP00000128	Atr13 Q5G7K8	Physiology	Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown	Hyaloperonospora parasitica (species)	Hyaloperonospora parasitica (species)	ATR13	Hyaloperonospora parasitica (species)	Published - Accepted by Curator
ATXN1	Body fat distribution (attenuation)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Chu AY; Deng X; Fisher VA ; et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]	GP00001552	ATXN1 P54253	Physiology	A>G in associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)	ATXN1	Homo sapiens human - (species)	Published - Accepted by Curator
AZI1	Root growth (root growth responses to low zinc conditions)	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Bouain N; Satbhai SB; Korte A ; et al. (2018) Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition.	GP00001769	AZI1 Q9SU35	Physiology	exact causing mutation(s) unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	AZI1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
B4GALNT2	Fertility (increased ovulation rate)	Cis-regulatory, Unknown	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Drouilhet L; Mansanet C; Sarry J ; et al. (2013) The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GAL[...]	GP00001979	B4galnt2 Q09199	Physiology	candidate region to 197kb ; putative mutation (g.36938224T>A) in intron 7or (g.37034573A>G) 96 kb away in an intergenic region	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	B4GALNT2	Ovis aries sheep - (species)	Published - Accepted by Curator
bab2	Fertility (ovariole number)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Green DA; Extavour CG (2012) Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...] 1 Additional References Bergland AO; Genissel A; Nuzhdin SV (2008) Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole [...]	GP00000132	bab2 Q9W0K4	Physiology	unknown ; loss of function reduces ovariole number	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	bab2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP	Glycine max soybean - (species)	Domesticated	Linkage Mapping	Juwattanasomran R; Somta P; Chankaew S ; et al. (2011) A SNP in GmBADH2 gene associates with fragrance in vegetable soybean variety "Kaori" and SNAP marker[...]	GP00000133	BADH2 Q84LK3	Physiology	1 amino-acid substitution in conserved enzymatic domain	Glycine max soybean - (species)	Glycine max soybean - (species)	BADH2	Glycine max soybean - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species)	Domesticated	Linkage Mapping	Bradbury LM; Fitzgerald TL; Henry RJ ; et al. (2005) The gene for fragrance in rice. 1 Additional References Kovach MJ; Calingacion MN; Fitzgerald MA (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00000134	BADH2 Q84LK3	Physiology	8bp deletion resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species)	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Shi Weiwei; Yang Yi; Chen Saihua ; et al. (2008 ) Discovery of a new fragrance allele and the development of functional markers for the breeding of fr[...] 1 Additional References Kovach MJ; Calingacion MN; Fitzgerald MA (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001772	BADH2 Q84LK3	Physiology	7-bp deletion in exon 2 resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001773	BADH2 Q84LK3	Physiology	2-bp deletion in exon 1 resulting in premature stop codon N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001774	BADH2 Q84LK3	Physiology	insertion of 1 bp (T) in exon 10 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001775	BADH2 Q84LK3	Physiology	G>T substitution in exon 10 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001776	BADH2 Q84LK3	Physiology	G>T substitution in exon 14 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, SNP N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001777	BADH2 Q84LK3	Physiology	C>T substitution in exon 13 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001778	BADH2 Q84LK3	Physiology	1-bp deletion in exon 10 - causes a frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001779	BADH2 Q84LK3	Physiology	1-bp insertion (G) in exon 14 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BADH2	Fragrance	Coding, Insertion N	Oryza sativa rice - (species) D	Domesticated	Candidate Gene	Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009) The origin and evolution of fragrance in rice (Oryza sativa L.).	GP00001780	BADH2 Q84LK3	Physiology	3-bp insertion (TAT) in exon 13 - causes a frameshift N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	BADH2	Oryza sativa rice - (species)	Published - Accepted by Curator
BAK1	Hematopoiesis (blood platelet count)	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001616	BAK1 Q16611	Physiology	A>G at the associated SNP	Homo sapiens human - (species)	Homo sapiens human - (species)	BAK1	Homo sapiens human - (species)	Published - Accepted by Curator
BBS9 (+ BMPER)	Growth rate	Coding, Deletion N	Sus scrofa domesticus domestic pig - (subspecies) D	Domesticated	Association Mapping	Derks MFL; Lopes MS; Bosse M ; et al. (2018) Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes[...]	GP00002341	Bbs9 Q811G0	Physiology	212kb deletion resulting in truncated BBS9 protein and recessive loss of neighbor gene expression BMPER N	Sus scrofa domesticus domestic pig - (subspecies)	Sus scrofa domesticus domestic pig - (subspecies) D	BBS9 (+ BMPER)	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
BCMA	Glucosinolate content Herbivore resistance	3 Mutations:	Boechera stricta (species)	Intraspecific	Linkage Mapping	Prasad KV; Song BH; Olson-Manning C ; et al. (2012) A gain-of-function polymorphism controlling complex traits and fitness in nature.	GP00000136	J9QWI9	Physiology Physiology	3 mutations	Boechera stricta (species)	Boechera stricta (species)	BCMA	Boechera stricta (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow serum)	Coding, SNP N	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Berry SD; Davis SR; Beattie EM ; et al. (2009) Mutation in bovine beta-carotene oxygenase 2 affects milk color. 1 Additional References Tian R; Pitchford WS; Morris CA (2010) Genetic variation in the beta, beta-carotene-9', 10'-dioxygenase gene and association with fat colou[...]	GP00000138	BCO2 Q9BYV7	Physiology	c.306G>A ; p.W102* N	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	BCO2 = beta-carotene oxygenase 2	Bos taurus cattle - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow fat)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Våge DI; Boman IA (2010) A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumula[...] 1 Additional References Niu Y; Jin M; Li Y (2017) Biallelic β-carotene oxygenase 2 knockout results in yellow fat in sheep via CRISPR/Cas9.	GP00000140	BCO2 Q9BYV7	Physiology	g.21947481C>T ; c.196C>T ; p.Q66* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BCO2 = beta-carotene oxygenase 2	Ovis aries sheep - (species)	Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2	Carotenoid content (yellow fat)	Coding, Deletion N	Oryctolagus cuniculus rabbit - (species) D	Domesticated	Candidate Gene	Strychalski J; Brym P; Czarnik U ; et al. (2015) A novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits.	GP00002152	BCO2 Q9BYV7	Physiology	AAT-deletion mutation at Asp codon 248 of the BCO2 gene located at the beginning of exon 6 which results in the removal of an Asp N	Oryctolagus cuniculus rabbit - (species)	Oryctolagus cuniculus rabbit - (species) D	BCO2 = beta-carotene oxygenase 2	Oryctolagus cuniculus rabbit - (species)	Published - Accepted by Curator
benzoic acid/salicylic acid carboxyl methyltransferase (BSMT)	Fragrance	Cis-regulatory, Unknown	Petunia axillaris (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001766	BSMT1 Q6XMI3	Physiology	Allele-specific expression in hybrids - de novo expression in P. axillaris	Petunia integrifolia subsp. inflata (subspecies)	Petunia axillaris (species) D	benzoic acid/salicylic acid carboxyl methyltransferase (BSMT)	Petunia axillaris (species)	Published - Accepted by Curator
benzoyl-CoA:benzylalcohol/2-phenylethanol benzoyltransferase (BPBT)	Fragrance	Cis-regulatory, Unknown	Petunia axillaris (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001765	BPBT A0A172W606	Physiology	Allele-specific expression in hybrids - de novo expression in P. axillaris	Petunia integrifolia subsp. inflata (subspecies)	Petunia axillaris (species) D	benzoyl-CoA:benzylalcohol/2-phenylethanol benzoyltransferase (BPBT)	Petunia axillaris (species)	Published - Accepted by Curator
beta-casein	Milk protein content (casein)	Coding, SNP	Bos taurus cattle - (species) D	Domesticated	Linkage Mapping	Gallinat JL; Qanbari S; Drögemüller C ; et al. (2013) DNA-based identification of novel bovine casein gene variants.	GP00002025	CSN2 P02666	Physiology	g.87181619A>C c.245A>C p.H82P CAT>CCT	Bos taurus cattle - (species)	Bos taurus cattle - (species) D	beta-casein	Bos taurus cattle - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001263	BGLU6 Q682B4	Physiology	T-> A of a splice site at position 168 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001264	BGLU6 Q682B4	Physiology	1-bp deletion of a splice site at position 395 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001265	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 913 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, Deletion N	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001266	BGLU6 Q682B4	Physiology	A deletion of one nucleotide in the seventh exon (BGLU6 CDS position 678) results in a premature stop codon in the accessions Bor-4, Se-0, Uod-1, and Zdr-1. premature stop codon N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)	Resistance to UV irradiation (flavonol glycosylation)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Ishihara H; Tohge T; Viehöver P ; et al. (2016) Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...] 1 Additional References Keurentjes JJ; Fu J; de Vos CH (2006) The genetics of plant metabolism.	GP00001267	BGLU6 Q682B4	Physiology	GAG to stop codon TAG at position 1138 N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Beta-glucosidase6 (BGLU6)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Kwa MS; Veenstra JG; Roos MH (1994) Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001785	TUB2 P02557	Physiology	Phe200Tyr	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D	beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Trichostrongylus colubriformis (species) D	Intraspecific	Candidate Gene	Kwa MS; Veenstra JG; Roos MH (1994) Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001786	TUB2 P02557	Physiology	Phe200Tyr	Trichostrongylus colubriformis (species)	Trichostrongylus colubriformis (species) D	beta-tubulin	Trichostrongylus colubriformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001788	TUB2 P02557	Physiology	Phe200Tyr	Venturia inaequalis (species)	Venturia inaequalis (species) D	beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001789	TUB2 P02557	Physiology	Phe200Tyr		D	beta-tubulin		Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium italicum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001790	TUB2 P02557	Physiology	Phe200Tyr	Penicillium italicum (species)	Penicillium italicum (species) D	beta-tubulin	Penicillium italicum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium aurantiogriseum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001791	TUB2 P02557	Physiology	Phe200Tyr	Penicillium aurantiogriseum (species)	Penicillium aurantiogriseum (species) D	beta-tubulin	Penicillium aurantiogriseum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium aurantiogriseum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001792	TUB2 P02557	Physiology	Glu198Lys	Penicillium aurantiogriseum (species)	Penicillium aurantiogriseum (species) D	beta-tubulin	Penicillium aurantiogriseum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium viridicatum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001793	TUB2 P02557	Physiology	Glu198Lys	Penicillium viridicatum (species)	Penicillium viridicatum (species) D	beta-tubulin	Penicillium viridicatum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Clarireedia homoeocarpa (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001794	TUB2 P02557	Physiology	Glu1198Lys	Clarireedia homoeocarpa (species)	Clarireedia homoeocarpa (species) D	beta-tubulin	Clarireedia homoeocarpa (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001795	TUB2 P02557	Physiology	Glu1198Lys	Venturia inaequalis (species)	Venturia inaequalis (species) D	beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Venturia inaequalis (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001796	TUB2 P02557	Physiology	Glu1198Ala	Venturia inaequalis (species)	Venturia inaequalis (species) D	beta-tubulin	Venturia inaequalis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001797	TUB2 P02557	Physiology	Glu1198Ala		D	beta-tubulin		Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Monilinia fructicola (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001798	TUB2 P02557	Physiology	Glu1198Lys	Monilinia fructicola (species)	Monilinia fructicola (species) D	beta-tubulin	Monilinia fructicola (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium puberulum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001799	TUB2 P02557	Physiology	Glu1198Lys	Penicillium puberulum (species)	Penicillium puberulum (species) D	beta-tubulin	Penicillium puberulum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium puberulum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001800	TUB2 P02557	Physiology	Glu1198Ala	Penicillium puberulum (species)	Penicillium puberulum (species) D	beta-tubulin	Penicillium puberulum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium digitatum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001801	TUB2 P02557	Physiology	Glu1198Lys	Penicillium digitatum (species)	Penicillium digitatum (species) D	beta-tubulin	Penicillium digitatum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium expansum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Fujimura M; Oeda K; Inoue H (1990 ) Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains	GP00001802	TUB2 P02557	Physiology	Glu1198Ala	Penicillium expansum (species)	Penicillium expansum (species) D	beta-tubulin	Penicillium expansum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benomyl)	Coding, SNP	Penicillium italicum (species) D	Intraspecific	Candidate Gene	Koenraadt Harrie; Somerville Shauna C; Jones AL Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001803	TUB2 P02557	Physiology	Glu198Lys	Penicillium italicum (species)	Penicillium italicum (species) D	beta-tubulin	Penicillium italicum (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Teladorsagia circumcincta (species) D	Intraspecific	Candidate Gene	Elard L; Humbert JF (1999) Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole[...]	GP00001815	TUB2 P02557	Physiology	Phe200Tyr	Teladorsagia circumcincta (species)	Teladorsagia circumcincta (species) D	beta-tubulin	Teladorsagia circumcincta (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Prichard R; Oxberry M; Bounhas Y ; et al. (2000 ) Polymerisation and benzimidazole binding assays with recombinant α-and β-tubulins from Haemonchus co[...] 2 Additional References Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...] Li J; Katiyar SK; Edlind TD (1996) Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 [...]	GP00001816	TUB2 P02557	Physiology	Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus b-tubulin (produced in a prokaryote system)	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D	beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Cyathostoma (genus) D	Intraspecific	Candidate Gene	Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...] 1 Additional References Li J; Katiyar SK; Edlind TD (1996) Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 [...]	GP00001817	TUB2 P02557	Physiology	Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus and S. cerevisiae b-tubulin (produced in a prokaryote system)	Cyathostoma (genus)	Cyathostoma (genus) D	beta-tubulin	Cyathostoma (genus)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Neurospora crassa (species) D	Intraspecific	Candidate Gene	Orbach MJ; Porro EB; Yanofsky C (1986) Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurosp[...]	GP00001818	TUB2 P02557	Physiology	Phe167Tyr	Neurospora crassa (species)	Neurospora crassa (species) D	beta-tubulin	Neurospora crassa (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Teladorsagia circumcincta (species) D	Intraspecific	Candidate Gene	Silvestre A; Cabaret J (2002) Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]	GP00001819	TUB2 P02557	Physiology	Phe167Tyr	Teladorsagia circumcincta (species)	Teladorsagia circumcincta (species) D	beta-tubulin	Teladorsagia circumcincta (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Haemonchus contortus barber pole worm - (species) D	Intraspecific	Candidate Gene	Ghisi M; Kaminsky R; Mäser P (2007) Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutatio[...]	GP00001820	TUB2 P02557	Physiology	Glu198Ala	Haemonchus contortus barber pole worm - (species)	Haemonchus contortus barber pole worm - (species) D	beta-tubulin	Haemonchus contortus barber pole worm - (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]	GP00001821	TUB2 P02557	Physiology	Phe200Tyr	Oculimacula yallundae (species)	Oculimacula yallundae (species) D	beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]	GP00001822	TUB2 P02557	Physiology	Phe200Tyr	Oculimacula acuformis (species)	Oculimacula acuformis (species) D	beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001823	TUB2 P02557	Physiology	E198A	Oculimacula acuformis (species)	Oculimacula acuformis (species) D	beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001824	TUB2 P02557	Physiology	E198G	Oculimacula acuformis (species)	Oculimacula acuformis (species) D	beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula acuformis (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001825	TUB2 P02557	Physiology	E198K	Oculimacula acuformis (species)	Oculimacula acuformis (species) D	beta-tubulin	Oculimacula acuformis (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001826	TUB2 P02557	Physiology	E198A	Oculimacula yallundae (species)	Oculimacula yallundae (species) D	beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001827	TUB2 P02557	Physiology	E198G	Oculimacula yallundae (species)	Oculimacula yallundae (species) D	beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001828	TUB2 P02557	Physiology	E198Q	Oculimacula yallundae (species)	Oculimacula yallundae (species) D	beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin	Xenobiotic resistance (benzimidazole)	Coding, SNP	Oculimacula yallundae (species) D	Intraspecific	Candidate Gene	Albertini Catherine; Gredt Michel; Leroux Pierre (1999 ) Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...] 1 Additional References Fujimura Makoto; Kamakura Takashi; Inoue Hirokazu (1992 ) Sensitivity of Neurospora crassa to benzimidazoles and N-phenylcarbamates: effect of amino acid subs[...]	GP00001829	TUB2 P02557	Physiology	L240F	Oculimacula yallundae (species)	Oculimacula yallundae (species) D	beta-tubulin	Oculimacula yallundae (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001830	TUB2 P02557	Physiology	A185P - missense_variant_c.553G>C_3539974 – A185P N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001832	TUB2 P02557	Physiology	stop_gained_HIGH_c.1267C>T_3538394 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001833	TUB2 P02557	Physiology	Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001834	TUB2 P02557	Physiology	missense_variant_MODERATE_c.1210G>A_3538451 – D404N N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001835	TUB2 P02557	Physiology	Del_3539006_3539808 – 802bp deletion of coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001836	TUB2 P02557	Physiology	stop_gained_HIGH_c.1135A>T_3539335 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001837	TUB2 P02557	Physiology	stop_gained_HIGH_c.1112C>A_3539358 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001838	TUB2 P02557	Physiology	Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001839	TUB2 P02557	Physiology	Del_3539470_3539471 – 1bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001840	TUB2 P02557	Physiology	Del_3539507_3539514 – 7bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001841	TUB2 P02557	Physiology	Del_3539559_3539745 – 186 bp deletion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001842	TUB2 P02557	Physiology	Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001843	TUB2 P02557	Physiology	missense_variant_MODERATE_c.771G>A_3539699 – M257I N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001844	TUB2 P02557	Physiology	Del_3539746_3539908 – 162 bp deletion in exon3-4 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001845	TUB2 P02557	Physiology	stop_gained_HIGH_c.549C>A_3539978 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001846	TUB2 P02557	Physiology	missense_variant_MODERATE_c.434C>T_3540145 – S145F N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001847	TUB2 P02557	Physiology	missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001848	TUB2 P02557	Physiology	Del_3540300_3540301 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Inversion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001849	TUB2 P02557	Physiology	Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Unknown N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001850	TUB2 P02557	Physiology	Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001851	TUB2 P02557	Physiology	Del_3540407_3540408 – 1bp deletion in coding exon 2 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001852	TUB2 P02557	Physiology	Del_3540970_3544000 – 3030bp deletion N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001853	TUB2 P02557	Physiology	Del_3541317_3541856 – 539 bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001854	TUB2 P02557	Physiology	splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, SNP N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001855	TUB2 P02557	Physiology	stop_gained_HIGH_c.153T>G_3541441 N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Deletion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001856	TUB2 P02557	Physiology	Del_3541499_3541502 – 3bp deletion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben-1)	Xenobiotic resistance (benzimidazole)	Coding, Insertion N	Caenorhabditis elegans (species) D	Intraspecific	Association Mapping	Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001857	TUB2 P02557	Physiology	Ins_3541547_3541548 – 1 bp insertion in first coding exon N	Caenorhabditis elegans (species)	Caenorhabditis elegans (species) D	beta-tubulin (ben-1)	Caenorhabditis elegans (species)	Published - Accepted by Curator
beta-tubulin (ben4)	Xenobiotic resistance (benzimidazole)	Coding, SNP	Aspergillus nidulans (species) D	Intraspecific	Candidate Gene	Jung MK; Wilder IB; Oakley BR (1992) Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl r[...] 1 Additional References Hahnel SR; Zdraljevic S; Rodriguez BC (2018) Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]	GP00001787	TUB2 P02557	Physiology	Phe200Tyr	Aspergillus nidulans (species)	Aspergillus nidulans (species) D	beta-tubulin (ben4)	Aspergillus nidulans (species)	Published - Accepted by Curator
BHLHE41	Hypoxia response	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Huerta-Sánchez E; Degiorgio M; Pagani L ; et al. (2013) Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.	GP00000144	BHLHE41 Q9C0J9	Physiology	unknown	Homo sapiens human - (species)	Homo sapiens human - (species)	BHLHE41	Homo sapiens human - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001488	BMH1 P29311	Physiology	C>G p.Y216* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001489	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001490	BMH1 P29311	Physiology	A>T p.K217* (2 times independently). Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001491	BMH1 P29311	Physiology	G>A p.D101N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001492	BMH1 P29311	Physiology	T>G p.L230* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001493	BMH1 P29311	Physiology	C>A p.N178K located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001494	BMH1 P29311	Physiology	G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001495	BMH1 P29311	Physiology	G>T p.G174V homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001496	BMH1 P29311	Physiology	G>A p.G174D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001497	BMH1 P29311	Physiology	A>G p.N178S homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMH1	Growth rate (time to diauxic shift)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Spor A; Kvitek DJ; Nidelet T ; et al. (2014) Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]	GP00001498	BMH1 P29311	Physiology	G>A p.G55D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	BMH1	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BMP receptor IB (BMPRIB)	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Mulsant P; Lecerf F; Fabre S ; et al. (2001) Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Bo[...]	GP00000146	BMPR-IB Q9BDI4	Physiology	g.29382188A>G c.914A>G p.Q305R	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP receptor IB (BMPRIB)	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000147	Bmp15 Q9Z0L4	Physiology	c.67C>T p.Q23* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00000148	Bmp15 Q9Z0L4	Physiology	A distinct single T>A transition occurs in FecXI carriers at nucleotide position 92 of the mature peptide . . . The mutation substitutes valine (V) with aspartic acid (D) at residue 31 (residue 299 of unprocessed protein) . . . The FecXI mutation is a non-conservative change in a highly conserved region of the protein	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00000149	Bmp15 Q9Z0L4	Physiology	c.950C>T p.T317I	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00000150	Bmp15 Q9Z0L4	Physiology	c.1009A>C p.N337H	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004) Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]	GP00002155	Bmp15 Q9Z0L4	Physiology	c.718C>T ; p.Q239* N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Linkage Mapping	Galloway SM; McNatty KP; Cambridge LM ; et al. (2000) Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]	GP00002156	Bmp15 Q9Z0L4	Physiology	c.G>A p.C321Y missense nonconservative substitution ; in vitro studies showed that the C53Y mutation was responsible for the impairment of the maturation process of the BMP15 protein resulting in a defective secretion of both the precursor and mature peptide	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, SNP	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004) Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]	GP00002157	Bmp15 Q9Z0L4	Physiology	c.1100G>T p.S367I	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, Deletion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Martinez-Royo A; Jurado JJ; Smulders JP ; et al. (2008) A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in R[...] 1 Additional References Monteagudo LV; Ponz R; Tejedor MT (2009) A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolif[...]	GP00002158	Bmp15 Q9Z0L4	Physiology	c.525_541del17 p.Pro45Asnfs*54 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Coding, Insertion N	Ovis aries sheep - (species) D	Domesticated	Candidate Gene	Lassoued N; Benkhlil Z; Woloszyn F ; et al. (2017) FecX a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine [...]	GP00002159	Bmp15 Q9Z0L4	Physiology	C insertion (c.310insC) in the ovine BMP15 cDNA leading to a frame shift at protein position 101 N	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP15	Fertility (increased ovulation rate)	Cis-regulatory, SNP	Ovis aries sheep - (species) D	Domesticated	Association Mapping	Demars J; Fabre S; Sarry J ; et al. (2013) Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]	GP00002329	Bmp15 Q9Z0L4	Physiology	T>A SPN upstream of the BMP15 gene associated with the prolificacy variability (P = 1.93E-11). Effect of +0.20 lamb per lambing at the heterozygous state.	Ovis aries sheep - (species)	Ovis aries sheep - (species) D	BMP15	Ovis aries sheep - (species)	Published - Accepted by Curator
BMP2	Fertility (egg production) Bird head morphology (male comb)	Cis-regulatory, Unknown	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Johnsson M; Gustafson I; Rubin CJ ; et al. (2012) A sexual ornament in chickens is affected by pleiotropic alleles at HAO1 and BMP2, selected during d[...] 1 Additional References Johnsson M; Rubin CJ; Höglund A (2014) The role of pleiotropy and linkage in genes affecting a sexual ornament and bone allocation in the c[...]	GP00000151	BMP2 Q90751	Physiology Morphology	unknown; but intergenic QTL peak with decomposed effects on expression of BMP2 and HAO1	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)	BMP2	Gallus gallus chicken - (species)	Published - Accepted by Curator
BNA1	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001878	BNA1 P47096	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA1	[Candida] glabrata (species)	Published - Accepted by Curator
BNA2	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001879	P47125	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA2	[Candida] glabrata (species)	Published - Accepted by Curator
BNA4	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001880	BNA4 P38169	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA4	[Candida] glabrata (species)	Published - Accepted by Curator
BNA5	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001881	BNA5 Q05979	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA5	[Candida] glabrata (species)	Published - Accepted by Curator
BNA6	Nicotinid acid metabolism	Gene Loss, Deletion N	[Candida] glabrata (species) D	Interspecific	Candidate Gene	Domergue R; Castaño I; De Las Peñas A ; et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.	GP00001882	BNA6 P43619	Physiology	Size of the deletion not mentioned in the paper N	Candida albicans (species)	[Candida] glabrata (species) D	BNA6	[Candida] glabrata (species)	Published - Accepted by Curator
BOLTING TIME CONTROL 1 (BvBTC1)	Flowering time	Cis-regulatory, Unknown	Beta vulgaris (species)	Domesticated	Linkage Mapping	Pin PA; Zhang W; Vogt SH ; et al. (2012) The role of a pseudo-response regulator gene in life cycle adaptation and domestication of beet.	GP00000155	BTC1 I3NN18	Physiology	unknown	Beta vulgaris (species)	Beta vulgaris (species)	BOLTING TIME CONTROL 1 (BvBTC1)	Beta vulgaris (species)	Published - Accepted by Curator
Brevis radix (BRX)	pH tolerance (acidic soil)	Coding, SNP N	Arabidopsis thaliana thale cress - (species)	Intraspecific	Candidate Gene	Gujas B; Alonso-Blanco C; Hardtke CS (2012) Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil.	GP00001236	BRX Q17TI5	Physiology	K188* (stop codon) N	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Brevis radix (BRX)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
brittle endosperm2 (Bt2) = endosperm ADP-glucose pyrophosphorylase small subunit	Sweet and brittle seed	Unknown, Unknown	Zea mays (species)	Domesticated	Linkage Mapping	Preiss J; Danner S; Summers PS ; et al. (1990) Molecular Characterization of the Brittle-2 Gene Effect on Maize Endosperm ADPglucose Pyrophosphoryl[...]	GP00000158	bt2 Q84J79	Physiology	Not identified	Zea mays (species)	Zea mays (species)	brittle endosperm2 (Bt2) = endosperm ADP-glucose pyrophosphorylase small subunit	Zea mays (species)	Published - Accepted by Curator
Brix9-2-5/LIN5 invertase	Fruit sugar content	Unknown, Unknown	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Fridman E; Carrari F; Liu YS ; et al. (2004) Zooming in on a quantitative trait for tomato yield using interspecific introgressions.	GP00000159	LIN5 P93199	Physiology	Not identified	Solanum pennellii (species)	Solanum lycopersicum tomato - (species) D	Brix9-2-5/LIN5 invertase	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
BTN1A1	Pathogen resistance (virus)	Coding, SNP N	Gallus gallus chicken - (species)	Domesticated	Linkage Mapping	Elleder D; Stepanets V; Melder DC ; et al. (2005) The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian but[...]	GP00002160	BTN1A1 Q13410	Physiology	g.808011C>A c.165C>A p.C55* N	Gallus gallus chicken - (species)	Gallus gallus chicken - (species)	BTN1A1	Gallus gallus chicken - (species)	Published - Accepted by Curator
btr1	Seed shattering (grain dispersal ; retention)	Coding, Deletion N	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	Domesticated	Linkage Mapping	Pourkheirandish M; Hensel G; Kilian B ; et al. (2015) Evolution of the Grain Dispersal System in Barley.	GP00001445	BTR1 A0A0K1RJT0	Physiology	1bp deletion at position 202 inducing a frameshift N	Hordeum vulgare (species)	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	btr1	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies)	Published - Accepted by Curator
btr2	Seed shattering (grain dispersal ; retention)	Coding, Deletion N	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	Domesticated	Linkage Mapping	Pourkheirandish M; Hensel G; Kilian B ; et al. (2015) Evolution of the Grain Dispersal System in Barley.	GP00001446	BTR2 A0A0K1RKV9	Physiology	11bp deletion at position 254-264 creating a frameshift N	Hordeum vulgare (species)	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies) D	btr2	Hordeum vulgare subsp. vulgare domesticated barley - (subspecies)	Published - Accepted by Curator
BUL2	Telomere length Aging	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species)	Domesticated	Linkage Mapping	Kwan EX; Foss E; Kruglyak L ; et al. (2011) Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and tel[...]	GP00000166	BUL2 Q03758	Physiology Physiology	Leu883Phe	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species)	BUL2	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
BvCPSF73-Ia	Bolting time	Coding, Deletion N	Beta vulgaris (species) D	Intraspecific	Linkage Mapping	Tränkner C; Lemnian IM; Emrani N ; et al. (2016) A Detailed Analysis of the BR Locus Suggests a New Mechanism for Bolting after Winter in Sugar Beet [...]	GP00001411	CPSF73-I Q9C952	Physiology	2bp deletion causing a frameshift resulting in a two third truncated protein N	Beta vulgaris (species)	Beta vulgaris (species) D	BvCPSF73-Ia	Beta vulgaris (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, Unknown N	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Linkage Mapping	Xu X; Yu L; Wu Y (2005) Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]	GP00000160	BtR Q19KJ3	Physiology	premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	cadherin	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Insertion N	Heliothis virescens tobacco budworm - (species) D	Intraspecific	Linkage Mapping	Gahan LJ; Gould F; Heckel DG (2001) Identification of a gene associated with Bt resistance in Heliothis virescens.	GP00000161	BtR Q19KJ3	Physiology	Insertion of retrotransposon N	Heliothis virescens tobacco budworm - (species)	Heliothis virescens tobacco budworm - (species) D	cadherin	Heliothis virescens tobacco budworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000162	BtR Q19KJ3	Physiology	126bp in-frame deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000163	BtR Q19KJ3	Physiology	202bp deletion N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, Deletion	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Zhang H; Tian W; Zhao J (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000164	BtR Q19KJ3	Physiology	24bp in-frame deletion	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide)	Coding, SNP	Pectinophora gossypiella pink bollworm - (species) D	Intraspecific	Linkage Mapping	Zhang H; Tian W; Zhao J ; et al. (2012) Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.	GP00000165	BtR Q19KJ3	Physiology	E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac)	Coding, SNP N	Helicoverpa punctigera (species) D	Intraspecific	Candidate Gene	Walsh T; James B; Chakroun M ; et al. (2018) Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]	GP00002055	BtR Q19KJ3	Physiology	splice site GT mutated in GA so that splicing does not occur correctly and a 58 bp insertion is found in the cDNA sequence of the cadherin gene. This insertion disrupts the coding sequence in cadherin domain 9 causing a downstream frameshift and a premature stop codon for the rest of the protein. This would result in a truncated protein of 1243 amino acids without the putative binding domain; the membrane anchoring domain; presumably retained inside the cell and not exposed to the Cry1Ac; or alternatively; exported into the gut where it would be degraded N	Helicoverpa punctigera (species)	Helicoverpa punctigera (species) D	cadherin	Helicoverpa punctigera (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Insertion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm. 1 Additional References Fabrick JA; Mathew LG; Tabashnik BE (2011) Insertion of an intact CR1 retrotransposon in a cadherin gene linked with Bt resistance in the pink [...]	GP00002449	A0A1B0RHM4	Physiology	insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon designated CR1-1_Pg. Unlike most other CR1 elements CR1-1_Pg is intact and transcribed by a flanking promoter. It contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002450	A0A1B0RHM4	Physiology	24-bp deletion in putative exon 21 causing the loss of eight amino acid residues N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)	Coding, Deletion N	Pectinophora gossypiella pink bollworm - (species) D	Experimental Evolution	Candidate Gene	Morin S; Biggs RW; Sisterson MS ; et al. (2003) Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.	GP00002451	A0A1B0RHM4	Physiology	126-bp deletion spanning a putative intron 15/exon 16 splice site that introduces a premature stop codon and causes loss of the final 929 amino acid residues. N	Pectinophora gossypiella pink bollworm - (species)	Pectinophora gossypiella pink bollworm - (species) D	cadherin	Pectinophora gossypiella pink bollworm - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, Deletion	Ostrinia furnacalis Asian corn borer - (species) D	Intraspecific	Candidate Gene	Jin T; Chang X; Gatehouse AM ; et al. (2014) Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...] 1 Additional References Jurat-Fuentes JL; Heckel DG; Ferré J (2021) Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis.	GP00002464	A0A1B0RHM4	Physiology	MPR-r2 has a 26-amino acid residue deletion in the TBR which results in reduced binding of Cry1Ac compared to the MPR from the susceptible strain.	Ostrinia furnacalis Asian corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species) D	cadherin	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
cadherin	Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)	Coding, SNP	Ostrinia furnacalis Asian corn borer - (species) D	Intraspecific	Candidate Gene	Jin T; Chang X; Gatehouse AM ; et al. (2014) Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...] 1 Additional References Jurat-Fuentes JL; Heckel DG; Ferré J (2021) Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis.	GP00002465	A0A1B0RHM4	Physiology	Thr1457Ser	Ostrinia furnacalis Asian corn borer - (species)	Ostrinia furnacalis Asian corn borer - (species) D	cadherin	Ostrinia furnacalis Asian corn borer - (species)	Published - Accepted by Curator
calmodulin binding hydrolase	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001438	Q9FHQ0	Physiology	unknown	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D	calmodulin binding hydrolase	Arabidopsis arenosa (species)	Published - Accepted by Curator
Casparian strip membrane domain protein 1	Xenobiotic resistance (soil contamination; serpentine)	Unknown, Unknown	Arabidopsis arenosa (species) D	Intraspecific	Association Mapping	Arnold BJ; Lahner B; DaCosta JM ; et al. (2016) Borrowed alleles and convergence in serpentine adaptation.	GP00001432	CASP1 Q9SIH4	Physiology	five aa sustitutions	Arabidopsis arenosa (species)	Arabidopsis arenosa (species) D	Casparian strip membrane domain protein 1	Arabidopsis arenosa (species)	Published - Accepted by Curator
CAST	Meat tenderness	Cis-regulatory, Unknown	Sus scrofa domesticus domestic pig - (subspecies)	Domesticated	Linkage Mapping	Nonneman D; Lindholm-Perry AK; Shackelford SD ; et al. (2011) Predictive markers in calpastatin for tenderness in commercial pig populations.	GP00000170	CAST P20810	Physiology	4 candidate SNPs in putative enhancers with nuclear factor-binding properties	Sus scrofa pig - (species)	Sus scrofa domesticus domestic pig - (subspecies)	CAST	Sus scrofa domesticus domestic pig - (subspecies)	Published - Accepted by Curator
Catecholamines up	Bristle number Lifespan Locomotor activity Sleep	Coding, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Carbone MA; Jordan KW; Lyman RF ; et al. (2006) Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Droso[...] 1 Additional References Stein MB; Koverola C; Hanna C (1997) Hippocampal volume in women victimized by childhood sexual abuse.	GP00000172	Catsup Q9V3A4	Morphology Physiology Behavior Behavior	unknown; but most large-effect variants appear to be coding	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Catecholamines up	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cathepsin E	Digestion (absence of stomach)	2 Mutations: Coding N	Ornithorhynchus anatinus platypus - (species) D	Intergeneric or Higher	Candidate Gene	Ordoñez GR; Hillier LW; Warren WC ; et al. (2008) Loss of genes implicated in gastric function during platypus evolution.	GP00001910	CTSE P14091	Physiology	2 mutations	Monodelphis domestica gray short-tailed opossum - (species) Homo sapiens human - (species)	Ornithorhynchus anatinus platypus - (species) D	cathepsin E	Ornithorhynchus anatinus platypus - (species)	Published - Accepted by Curator
CBF gene cluster	Temperature tolerance (cold)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Gery C; Zuther E; Schulz E ; et al. (2011) Natural variation in the freezing tolerance of Arabidopsis thaliana: effects of RNAi-induced CBF dep[...]	GP00000174	B1NSN2	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CBF gene cluster	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CBF12	Temperature tolerance (cold)	Coding, Unknown	Triticum monococcum (species)	Domesticated	Linkage Mapping	Knox AK; Li C; Vágújfalvi A ; et al. (2008) Identification of candidate CBF genes for the frost tolerance locus Fr-Am2 in Triticum monococcum.	GP00000175	B1NSN2	Physiology	possibly 5a.a. deletion in DNA binding domain	Triticum monococcum (species)	Triticum monococcum (species)	CBF12	Triticum monococcum (species)	Published - Accepted by Curator
CBF2-CBF4; CBF13	Temperature tolerance (cold)	Gene Amplification, Complex Change	Hordeum vulgare (species)	Domesticated	Candidate Gene	Knox AK; Dhillon T; Cheng H ; et al. (2010) CBF gene copy number variation at Frost Resistance-2 is associated with levels of freezing tolerance[...]	GP00000176	B1NSN2	Physiology	tandem duplication of CBF2-CBF4 region and/or pseudogenisation of CBF13	Hordeum vulgare (species)	Hordeum vulgare (species)	CBF2-CBF4; CBF13	Hordeum vulgare (species)	Published - Accepted by Curator
CCAAT-enhancer-binding protein alpha (CEBPA)	Hematopoiesis (blood basophil count)	Cis-regulatory, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017) Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]	GP00001603	CEBPA P49715	Physiology	C>T at the associated SNP which resides 39kb dowstream from CEBPA near a separate enhancer that influences CEBPA expression along various myeloid lineages. T allele was associated with a 28.6% reduction in enhancer activity.	Homo sapiens human - (species)	Homo sapiens human - (species)	CCAAT-enhancer-binding protein alpha (CEBPA)	Homo sapiens human - (species)	Published - Accepted by Curator
CCL3L1	Pathogen resistance (HIV)	Gene Amplification, Indel	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Gonzalez E; Kulkarni H; Bolivar H ; et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.	GP00000177	CCL3L1 P16619	Physiology	Copy number Variant	Homo sapiens human - (species)	Homo sapiens human - (species) D	CCL3L1	Homo sapiens human - (species)	Published - Accepted by Curator
CENTRORADIALIS (HvCEN)	Flowering time Seasonal growth	Coding, SNP	Hordeum vulgare (species)	Domesticated	Linkage Mapping	Comadran J; Kilian B; Russell J ; et al. (2012) Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and [...]	GP00000179	CEN Q9ZNV5	Physiology Physiology	P135A	Hordeum vulgare (species)	Hordeum vulgare (species)	CENTRORADIALIS (HvCEN)	Hordeum vulgare (species)	Published - Accepted by Curator
CEP55	Recombination rate (female)	Unknown, Unknown	Bos taurus cattle - (species)	Domesticated	Association Mapping	Ma L; O'Connell JR; VanRaden PM ; et al. (2015) Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.	GP00001667	CEP55 E1B8M0	Physiology	Associated SNP located near the gene	Bos taurus cattle - (species)	Bos taurus cattle - (species)	CEP55	Bos taurus cattle - (species)	Published - Accepted by Curator
Cf-2.1 and Cf-2.2	Pathogen resistance (leaf mold fungus ; root parasitic nematode)	Gene Loss, Deletion N	Solanum lycopersicum tomato - (species) D	Domesticated	Linkage Mapping	Dixon MS; Jones DA; Keddie JS ; et al. (1996) The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat[...] 2 Additional References Dixon MS; Hatzixanthis K; Jones DA (1998) The tomato Cf-5 disease resistance gene and six homologs show pronounced allelic variation in leucin[...] Lozano-Torres JL; Wilbers RH; Gawronski P (2012) Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence t[...]	GP00000180	Q41398	Physiology	loss of the two genes Cf-2.1 and Cf-2.2 (see Dixon et al. 1998) in cultivated tomato - resistance re-acquired from related species N	Solanum pimpinellifolium (species)	Solanum lycopersicum tomato - (species) D	Cf-2.1 and Cf-2.2	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
Cf-4/9	Pathogen resistance	Gene Loss, Complex Change	Solanum lycopersicum tomato - (species)	Domesticated	Linkage Mapping	Parniske M; Hammond-Kosack KE; Golstein C ; et al. (1997) Novel disease resistance specificities result from sequence exchange between tandemly repeated genes[...]	GP00000181	Cf-4A Q7DLS4	Physiology	partial loss of two gene coding regions located in tandem; resulting in a chimeric gene	Solanum pimpinellifolium (species)	Solanum lycopersicum tomato - (species)	Cf-4/9	Solanum lycopersicum tomato - (species)	Published - Accepted by Curator
CG11699	Xenobiotic resistance	Cis-regulatory, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Association Mapping	Mateo L; Ullastres A; González J (2014) A transposable element insertion confers xenobiotic resistance in Drosophila.	GP00001399	Dmel\CG11699 Q9VYX5	Physiology	insertion of a 186bp POGON1 element in the 3'UTR	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CG11699	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CG8492	Pathogen resistance (Drosophila C virus & flock house virus)	Unknown, Unknown	Drosophila melanogaster fruit fly - (species) D	Experimental Evolution	Association Mapping	Martins NE; Faria VG; Nolte V ; et al. (2014) Host adaptation to viruses relies on few genes with different cross-resistance properties.	GP00001481	Dmel\CG8492 Q9VSA5	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CG8492	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Chalk5	Grain chalkiness Amylose content Grain yield	Cis-regulatory, SNP	Oryza sativa rice - (species)	Intraspecific	Linkage Mapping	Li Y; Fan C; Xing Y ; et al. (2014) Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase influencing grain chalkiness in rice.	GP00001309	Chalk5 A2Y0L3	Morphology Physiology Physiology	Two candidate SNPs at positions -721 and - 485 in promoter region	Oryza sativa rice - (species)	Oryza sativa rice - (species)	Chalk5	Oryza sativa rice - (species)	Published - Accepted by Curator
Chit beta-GlcNAcase	Silk fineness	Cis-regulatory, Unknown	Bombyx mori domestic silkworm - (species) D	Domesticated	Association Mapping	Tong X; Han MJ; Lu K ; et al. (2022) High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]	GP00002401	P49010	Physiology	BmChit β-GlcNAcase gene is expressed at a significantly higher level in fine silk strains (Suxiu, Chunfeng) compared to coarse silk strains. CRISPR-cas9 mediated knockout of the BmChit β-GlcNAcase gene produced coarser silk.	Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	Chit beta-GlcNAcase	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide ; benzoylurea)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Douris V; Steinbach D; Panteleri R ; et al. (2016) Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]	GP00001600	CHS1 A3KCN0	Physiology	T>G p.I1042M (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	Chitin synthase 1 (CHS1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; benzoylurea)	Coding, SNP	Plutella xylostella diamondback moth - (species)	Intraspecific	Candidate Gene	Douris V; Steinbach D; Panteleri R ; et al. (2016) Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]	GP00001601	CHS1 A3KCN0	Physiology	A>T p.I1042F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species)	Chitin synthase 1 (CHS1)	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; etoxazole acaricide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species)	Intraspecific	Linkage Mapping	Demaeght P; Osborne EJ; Odman-Naresh J ; et al. (2014) High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally di[...] 1 Additional References Van Leeuwen T; Demaeght P; Osborne EJ (2012) Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin s[...]	GP00001602	chs1 H9U0G2	Physiology	A>T p.I1017F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species)	Chitin synthase 1 (CHS1)	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Chitin synthase 1 (CHS1)	Xenobiotic resistance (insecticide; benzoylurea)	Coding, SNP	Frankliniella occidentalis western flower thrips - (species) D	Intraspecific	Candidate Gene	Suzuki Y; Shiotsuki T; Jouraku A ; et al. (2017) Benzoylurea resistance in western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae)[...]	GP00002628	CHS1 A3KCN0	Physiology	isoleucine to methionine	Frankliniella occidentalis western flower thrips - (species)	Frankliniella occidentalis western flower thrips - (species) D	Chitin synthase 1 (CHS1)	Frankliniella occidentalis western flower thrips - (species)	Published - Accepted by Curator
CHKov1	Pathogen resistance Xenobiotic resistance (insecticide)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Magwire MM; Bayer F; Webster CL ; et al. (2011) Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...] 1 Additional References Aminetzach YT; Macpherson JM; Petrov DA (2005) Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila.	GP00000182	CHKov1 Q961V7	Physiology Physiology	Insertion of a Doc TE element resulting in novel; seemingly functional short protein	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	CHKov1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
chloroquine resistance transporter	Xenobiotic resistance (artemisinin)	Coding, SNP	Plasmodium falciparum malaria parasite P. falciparum - (species) D	Intraspecific	Association Mapping	Miotto O; Amato R; Ashley EA ; et al. (2015) Genetic architecture of artemisinin-resistant Plasmodium falciparum.	GP00001533	CRT Q9N623	Physiology	p.Ile356Thr	Plasmodium falciparum malaria parasite P. falciparum - (species)	Plasmodium falciparum malaria parasite P. falciparum - (species) D	chloroquine resistance transporter	Plasmodium falciparum malaria parasite P. falciparum - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Erinaceus concolor southern white-breasted hedgehog - (species) D Erinaceus europaeus western European hedgehog - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00000183	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Erinaceus concolor southern white-breasted hedgehog - (species) D Erinaceus europaeus western European hedgehog - (species) D	CHRNA1	Erinaceus concolor southern white-breasted hedgehog - (species) Erinaceus europaeus western European hedgehog - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Mellivora capensis ratel - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00000184	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Mellivora capensis ratel - (species) D	CHRNA1	Mellivora capensis ratel - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	4 Mutations: Coding SNP	Herpestes ichneumon Egyptian mongoose - (species) D	Intergeneric or Higher	Candidate Gene	Barchan D; Kachalsky S; Neumann D ; et al. (1992) How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. 2 Additional References Kachalsky SG; Jensen BS; Barchan D (1995) Two subsites in the binding domain of the acetylcholine receptor: an aromatic subsite and a proline [...] Barchan D; Kachalsky S; Neumann D (1992) How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.	GP00001686	CHRNA1 P02708	Physiology	4 mutations	Carnivora carnivores - (order)	Herpestes ichneumon Egyptian mongoose - (species) D	CHRNA1	Herpestes ichneumon Egyptian mongoose - (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	Coding, SNP	Naja haje (species) D	Intergeneric or Higher	Candidate Gene	Takacs Z; Wilhelmsen KC; Sorota S (2004) Cobra ( Naja spp. ) nicotinic acetylcholine receptor exhibits resistance to Erabu sea snake ( Latica[...]	GP00001720	CHRNA1 P02708	Physiology	Phe189Asn - The inhibitory effect on the pharmacological action of the toxin is primarily attributed to the presence of glycosylation at position N189.	Carnivora carnivores - (order)	Naja haje (species) D	CHRNA1	Naja haje (species)	Published - Accepted by Curator
CHRNA1	Xenobiotic resistance (snake venom)	2 Mutations: Coding SNP	Sus scrofa pig - (species) D	Intergeneric or Higher	Candidate Gene	Drabeck DH; Dean AM; Jansa SA (2015) Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]	GP00001721	CHRNA1 P02708	Physiology	2 mutations	Carnivora carnivores - (order)	Sus scrofa pig - (species) D	CHRNA1	Sus scrofa pig - (species)	Published - Accepted by Curator
CHRNA3/5 nicotine receptor cluster	Aging Smoking behavior	Unknown, Unknown	Homo sapiens human - (species)	Intraspecific	Association Mapping	Joshi PK; Fischer K; Schraut KE ; et al. (2016) Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.	GP00000185	CHRNA3 P32297	Physiology Physiology	unknown; complex variation with SNP association signal	Homo sapiens human - (species)	Homo sapiens human - (species)	CHRNA3/5 nicotine receptor cluster	Homo sapiens human - (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	3 Mutations: N	Petunia exserta (species) D	Interspecific	Linkage Mapping	Amrad A; Moser M; Mandel T ; et al. (2016) Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]	GP00001391	CNL A0A172W603	Physiology	3 mutations	Petunia axillaris (species)	Petunia exserta (species) D	Cinnamate-CoA ligase 1 (CNL1)	Petunia exserta (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, SNP N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001767	CNL A0A172W603	Physiology	serine-to-arginine exchange at position 453 (T-to-A nucleotide exchange at genomic position 7 539 424) - this mutation is located immediately next to highly conserved amino acids predicted to be involved in adenosine monophosphate and coenzyme A binding; it involves two biochemically very dissimilar amino acids; and the serine at this position is conserved N	Capsella grandiflora (species)	Capsella rubella (species) D	Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)	Fragrance	Coding, Deletion N	Capsella rubella (species) D	Interspecific	Linkage Mapping	Sas C; Müller F; Kappel C ; et al. (2016) Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]	GP00001768	CNL A0A172W603	Physiology	a 4 bp deletion resulting in a frameshift 795 bp downstream of the start codon and causing a premature stop codon N	Capsella grandiflora (species)	Capsella rubella (species) D	Cinnamate-CoA ligase 1 (CNL1)	Capsella rubella (species)	Published - Accepted by Curator
CINNAMOYL CO-A REDUCTASE 1	Fiber content	Coding, Unknown N	Brassica napus rape - (species)	Domesticated	Linkage Mapping	Liu L; Stein A; Wittkop B ; et al. (2012) A knockout mutation in the lignin biosynthesis gene CCR1 explains a major QTL for acid detergent lig[...]	GP00000186	CCR1 Q9S9N9	Physiology	Frameshift mutation in exon1 N	Brassica napus rape - (species)	Brassica napus rape - (species)	CINNAMOYL CO-A REDUCTASE 1	Brassica napus rape - (species)	Published - Accepted by Curator
CIS1	Xenobiotic resistance (citrinin)	Cis-regulatory, Unknown	Saccharomyces paradoxus (species) D	Domesticated	Association Mapping	Naranjo S; Smith JD; Artieri CG ; et al. (2015) Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.	GP00001313	ATG31 Q12421	Physiology	mutations within 1kb in promotor region	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces paradoxus (species) D	CIS1	Saccharomyces paradoxus (species)	Published - Accepted by Curator
CLH1	Xenobiotic resistance (fungicide: guazatine)	Unknown, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Association Mapping	Atanasov KE; Barboza-Barquero L; Tiburcio AF ; et al. (2016) Genome Wide Association Mapping for the Tolerance to the Polyamine Oxidase Inhibitor Guazatine in Ar[...]	GP00001234	CLH1 O22527	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CLH1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Clock	Circadian rhythm	Unknown, Unknown	Bombyx mori domestic silkworm - (species) D	Domesticated	Association Mapping	Xiang H; Liu X; Li M ; et al. (2018) The evolutionary road from wild moth to domestic silkworm. 1 Additional References Tong X; Han MJ; Lu K (2022) High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]	GP00002409	Clk O61735	Physiology		Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	Clock	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
CmACS-7	Flower sex determination (male organs)	Coding, SNP	Cucumis melo muskmelon - (species)	Domesticated	Linkage Mapping	Boualem A; Fergany M; Fernandez R ; et al. (2008) A conserved mutation in an ethylene biosynthesis enzyme leads to andromonoecy in melons.	GP00000187	ACS7 Q9STR4	Physiology	A57V	Cucumis melo muskmelon - (species)	Cucumis melo muskmelon - (species)	CmACS-7	Cucumis melo muskmelon - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 1 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.	GP00002163	Cmah Q61419	Physiology	c.179G>T p.G60V	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 1 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats.	GP00002164	Cmah Q61419	Physiology	c.364C>T p.P122S	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, Deletion N	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Kehl A; Heimberger K; Langbein-Detsch I (2018) Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping sch[...]	GP00002165	Cmah Q61419	Physiology	c.1322delT p.Leu441* N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002166	Cmah Q61419	Physiology	c.139G>A p.V47M	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002167	Cmah Q61419	Physiology	c.268T>A p.Y89N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CMAH	Blood type (feline ABC)	Coding, SNP	Felis catus domestic cat - (species) D	Intraspecific	Candidate Gene	Omi T; Nakazawa S; Udagawa C ; et al. (2016) Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...] 2 Additional References Kehl A; Mueller E; Giger U (2019) CMAH genotyping survey for blood types A, B and C (AB) in purpose-bred cats. Bighignoli B; Niini T; Grahn RA (2007) Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domest[...]	GP00002168	Cmah Q61419	Physiology	c.1600G>A p.D534N	Felis catus domestic cat - (species)	Felis catus domestic cat - (species) D	CMAH	Felis catus domestic cat - (species)	Published - Accepted by Curator
CmWIP1	Flower sex determination (female vs. hermaphrodite)	Cis-regulatory, Insertion	Cucumis melo muskmelon - (species) D	Domesticated	Linkage Mapping	Martin A; Troadec C; Boualem A ; et al. (2009) A transposon-induced epigenetic change leads to sex determination in melon.	GP00000188	WIP1 Q8GXA4	Physiology	Promoter insertion of a Transcription Factor Binding Site allowing propagation of heritable methylation	Cucumis melo muskmelon - (species)	Cucumis melo muskmelon - (species) D	CmWIP1	Cucumis melo muskmelon - (species)	Published - Accepted by Curator
CNL9 (=Sr35)	Pathogen resistance	Coding, Complex Change	Triticum monococcum (species)	Domesticated	Linkage Mapping	Saintenac C; Zhang W; Salcedo A ; et al. (2013) Identification of wheat gene Sr35 that confers resistance to Ug99 stem rust race group.	GP00000189	Sr35 S5ABD6	Physiology	Coding variation in the LRR domain - a spontaneous gene conversion between CNL4 and CNL9 is the most parsimonious explanation for the three linked mutations in CNL9	Triticum monococcum (species)	Triticum monococcum (species)	CNL9 (=Sr35)	Triticum monococcum (species)	Published - Accepted by Curator
Couch potato	Diapause	Coding, SNP	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Schmidt PS; Zhu CT; Das J ; et al. (2008) An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]	GP00000191	cpo Q01617	Physiology	Ile462Lys	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Couch potato	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
COX18	Low-glucose adaptation (experimental evolution)	Coding, SNP	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Kao KC; Sherlock G (2008) Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...] 1 Additional References Kvitek DJ; Sherlock G (2011) Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugg[...]	GP00001708	COX18 P53239	Physiology	Leu59His (T>A at position 617107 according to Table 1) - CTY to CAY position 617107	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	COX18	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CPLX1	Recombination rate	Unknown, Unknown	Bos taurus cattle - (species)	Domesticated	Association Mapping	Ma L; O'Connell JR; VanRaden PM ; et al. (2015) Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.	GP00001659	CPLX1 Q0IIL7	Physiology	On chromosome 6. Associated SNP in the intron of the gene	Bos taurus cattle - (species)	Bos taurus cattle - (species)	CPLX1	Bos taurus cattle - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, SNP N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002102	Q95WY5	Physiology	Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin. N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Insertion N	Culex pipiens northern house mosquito - (species) D	Intraspecific	Candidate Gene	Darboux I; Charles JF; Pauchet Y ; et al. (2007) Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]	GP00002103	Q95WY5	Physiology	Insertion of a 451-bpTE into the exon 2 of the toxin receptor gene. The insertion induces a new mRNA splicing event that creates a shorter transcript. This new transcript encodes an altered receptor unable to interact with the toxin resulting in resistance to this insecticide. The missing portion includes GPI-anchoring signals N	Culex pipiens northern house mosquito - (species)	Culex pipiens northern house mosquito - (species) D	Cpm1	Culex pipiens northern house mosquito - (species)	Published - Accepted by Curator
Cpm1	Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)	Coding, Deletion N	Culex quinquefasciatus southern house mosquito - (species) D	Intraspecific	Candidate Gene	Guo QY; Cai QX; Yan JP ; et al. (2013) Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaeri[...] 1 Additional References Darboux I; Pauchet Y; Castella C (2002) Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.	GP00002552	Q95WY5	Physiology	one-nucleotide deletion which results in a premature stop codon and leads to production of a truncated protein. N	Culex quinquefasciatus southern house mosquito - (species)	Culex quinquefasciatus southern house mosquito - (species) D	Cpm1	Culex quinquefasciatus southern house mosquito - (species)	Published - Accepted by Curator
CPR	Xenobiotic resistance	Gene Amplification, Insertion	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Linkage Mapping	Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021) High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]	GP00002398	Cpr Q27597	Physiology	Pyflubumide resistant populations are estimated to harbor three CPR copies by two methods, whereas susceptible populations have a single CPR copy.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	CPR	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
Cryptochrome 2 (CRY2)	Circadian rhythm	Unknown, Unknown	Bombyx mori domestic silkworm - (species) D	Domesticated	Association Mapping	Xiang H; Liu X; Li M ; et al. (2018) The evolutionary road from wild moth to domestic silkworm. 1 Additional References Tong X; Han MJ; Lu K (2022) High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]	GP00002408	cry O77059	Physiology		Bombyx mori domestic silkworm - (species)	Bombyx mori domestic silkworm - (species) D	Cryptochrome 2 (CRY2)	Bombyx mori domestic silkworm - (species)	Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele	Flowering time Fruit shape (fruit length) Flower morphology (ovule number per fruit) Fertility (percentage of unfertilized ovules)	Coding, SNP	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001) A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2. 3 Additional References Olsen KM; Halldorsdottir SS; Stinchcombe JR (2004) Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles. el-Assal SE; Alonso-Blanco C; Hanhart CJ (2004) Pleiotropic effects of the Arabidopsis cryptochrome 2 allelic variation underlie fruit trait-related[...] Botto JF; Alonso-Blanco C; Garzarón I (2003) The Cape Verde Islands allele of cryptochrome 2 enhances cotyledon unfolding in the absence of blue [...]	GP00000192	CRY2 Q96524	Physiology Morphology Morphology Physiology	V367M	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	Cryptochrome 2 (CRY2) EDI allele	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CS	Plant secondary metabolite (pungency)	Cis-regulatory, Deletion N	Capsicum annuum (species) D	Domesticated	Candidate Gene	Kim S; Park M; Yeom SI ; et al. (2014) Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...] 1 Additional References Stewart C; Kang BC; Liu K (2005) The Pun1 gene for pungency in pepper encodes a putative acyltransferase.	GP00001447	csy1 Q09UW1	Physiology	Large 2.5 kb deletion spanning 1.8 kb of the putative promoter and 0.7 kb of the first exon was observed in the C. annuum Bellpeppers N	Capsicum frutescens (species)	Capsicum annuum (species) D	CS	Capsicum annuum (species)	Published - Accepted by Curator
CXCL16	Pathogen resistance (lymphocyte susceptibility to virus)	Coding, SNP	Equus caballus horse - (species)	Intraspecific	Association Mapping	Sarkar S; Bailey E; Go YY ; et al. (2016) Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus In[...]	GP00001591	CXCL16 F7CTX0	Physiology	4 candidate nonsynonymous substitutions within exon 1(in 2 susceptible variants): (1)c.715A>T p.Tyr40Phe (2)c.801G>C w.Asp49His (3)c.804T>A/G p.Phe50Ile (4)c.810G>A p.Glu52Lys	Equus caballus horse - (species)	Equus caballus horse - (species)	CXCL16	Equus caballus horse - (species)	Published - Accepted by Curator
CYC8	Salt tolerance (experimental evolution)	Coding, SNP N	Saccharomyces cerevisiae baker's yeast - (species) D	Experimental Evolution	Association Mapping	Anderson JB; Funt J; Thompson DA ; et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...] 1 Additional References Parreiras LS; Kohn LM; Anderson JB (2011) Cellular effects and epistasis among three determinants of adaptation in experimental populations of[...]	GP00000195	CYC8 P14922	Physiology	1bp substitution resulting in premature stop codon N	Saccharomyces cerevisiae baker's yeast - (species)	Saccharomyces cerevisiae baker's yeast - (species) D	CYC8	Saccharomyces cerevisiae baker's yeast - (species)	Published - Accepted by Curator
CYCD5;1	Endoreduplication	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Sterken R; Kiekens R; Boruc J ; et al. (2012) Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoredupl[...]	GP00000196	CYCD5-1 Q2V3B2	Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CYCD5;1	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Cyp12d1	Xenobiotic resistance (caffeine tolerance)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species)	Intraspecific	Linkage Mapping	Najarro MA; Hackett JL; Smith BR ; et al. (2015) Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.	GP00000198	Cyp12d1-d Q7KR10	Physiology	Copy number Variant	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Cyp12d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP1A2	Enzymatic activity	Coding, SNP	Homo sapiens human - (species) D	Intraspecific	Candidate Gene	Murayama N; Soyama A; Saito Y ; et al. (2004) Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]	GP00000199	CYP1A2 P05177	Physiology	F186L	Homo sapiens human - (species)	Homo sapiens human - (species) D	CYP1A2	Homo sapiens human - (species)	Published - Accepted by Curator
Cyp28d1	Xenobiotic resistance (nicotine ; larval stage)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chakraborty M; VanKuren NW; Zhao R ; et al. (2018) Hidden genetic variation shapes the structure of functional elements in Drosophila. 2 Additional References Marriage TN; King EG; Long AD (2014) Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cr[...] Chakraborty M; Emerson JJ; Macdonald SJ (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00001407	Cyp28d1 Q9VMT5	Physiology	insertion of a partial 1.5kb Accord transposable element and a Cyp28d1 gene tandem duplication (CNV - 3754 bp) that may play complementary role in resistance levels	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Cyp28d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cyp28d1	Xenobiotic resistance (nicotine ; larval stage)	Coding, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002113	Cyp28d1 Q9VMT5	Physiology	insertion of a FW element (4720 bp) into the coding region (exon) of the second copy of the Cyp28d1 (there is still another copy of the gene left due to a duplication). Associated with a decrease in Cyp28d2 gene expression and a decrease in nicotin resistance.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Cyp28d1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cyp28d1-Cyp28d2	Xenobiotic resistance (nicotine ; larval stage)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002112	Cyp28d1 Q9VMT5	Physiology	duplication of 6063 bp which includes genes Cyp28d1; Cyp28d2 and CG7742. Associated with increased expression of Cyp28d2 and increased resistance to nicotin	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Cyp28d1-Cyp28d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
Cyp28d1-Cyp28d2	Xenobiotic resistance (nicotine ; larval stage)	Gene Amplification, Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019) Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.	GP00002114	Cyp28d1 Q9VMT5	Physiology	duplication of a 15297-bp region; which encompasses 5 genes: Msp300 Cyp28d2 Cyp28d1 CG7742 and CG14034. Associated with increased expression of Cyp28d1 gene expression and increased nicotin resistance	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	Cyp28d1-Cyp28d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP2C9	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000200	CYP2C9 P11712	Physiology	I359L	Homo sapiens human - (species)	Homo sapiens human - (species)	CYP2C9	Homo sapiens human - (species)	Published - Accepted by Curator
CYP321A8	Xenobiotic resistance (organophosphate; chlorpyrifos; pyrethroid; cypermethrin; deltamethrin)	Cis-regulatory, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Candidate Gene	Hu B; Huang H; Hu S ; et al. (2021) Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron [...]	GP00002394	CYP321A8 A0A286QUG5	Physiology	A > G at position -197bp in a cis-regulatory region, leading to increased expression of the gene	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D	CYP321A8	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Association Mapping	Joußen N; Agnolet S; Lorenz S ; et al. (2012) Resistance of Australian Helicoverpa armigera to fenvalerate is due to the chimeric P450 enzyme CYP3[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002477	CYP337B3 A0A0H3V333	Physiology	The unique P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The exclusive presence of CYP337B3 in resistant insects of this strain confers a 42-fold resistance to fenvalerate.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Rasool Akhtar; Joußen Nicole; Lorenz Sybille ; et al. (2014 ) An independent occurrence of the chimeric P450 enzyme CYP337B3 of Helicoverpa armigera confers cyper[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002478	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The Pakistani and the Australian CYP337B3 alleles differ by 18 synonymous and three nonsynonymous SNPs and additionally in the length and sequence of the intron.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002479	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002480	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015 ) Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...] 1 Additional References Walsh TK; Joussen N; Tian K (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002481	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002482	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002483	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Complex Change	Helicoverpa armigera cotton bollworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]	GP00002484	CYP337B3 A0A0H3V333	Physiology	The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.	Helicoverpa armigera cotton bollworm - (species)	Helicoverpa armigera cotton bollworm - (species) D	CYP337B3	Helicoverpa armigera cotton bollworm - (species)	Published - Accepted by Curator
CYP337B3	Xenobiotic resistance (insecticide; pyrethroid)	Coding, Insertion	Helicoverpa zea corn earworm - (species) D	Intraspecific	Candidate Gene	Walsh TK; Joussen N; Tian K ; et al. (2018) Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...] 1 Additional References Valencia-Montoya WA; Elfekih S; North HL (2020) Adaptive Introgression across Semipermeable Species Boundaries between Local Helicoverpa zea and Inv[...]	GP00002485	CYP337B3 A0A0H3V333	Physiology	Introgression of the CYP337B3v2 resistant allele from Helicoverpa armigera	Helicoverpa zea corn earworm - (species)	Helicoverpa zea corn earworm - (species) D	CYP337B3	Helicoverpa zea corn earworm - (species)	Published - Accepted by Curator
CYP392A16	Xenobiotic resistance (insecticide)	Coding, SNP	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Candidate Gene	Anazawa Y; Tomita T; Aiki Y ; et al. (2003) Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...] 1 Additional References Papapostolou KM; Riga M; Samantsidis GR (2022) Over-expression in cis of the midgut P450 CYP392A16 contributes to abamectin resistance in Tetranych[...]	GP00002471	Ace P07140	Physiology	several non-synonymous SNP - exact causing amino acid change(s) unknown. Functional analysis of the putative promoter region from the resistant and susceptible parental strains revealed a higher reporter gene expression confirming the presence of cis-acting regulatory mechanisms.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	CYP392A16	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CYP392E8	Xenobiotic resistance	Cis-regulatory, Unknown	Tetranychus urticae two-spotted spider mite - (species) D	Intraspecific	Linkage Mapping	Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021) High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]	GP00002397		Physiology	increase in transcription of CYP392E8.	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	CYP392E8	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
CYP4F2	Xenobiotic resistance (anti-coagulant drug response)	Coding, SNP	Homo sapiens human - (species)	Intraspecific	Association Mapping	Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...] 1 Additional References Cha PC; Mushiroda T; Takahashi A (2010) Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanes[...]	GP00000203	CYP4F2 P78329	Physiology	V433M	Homo sapiens human - (species)	Homo sapiens human - (species)	CYP4F2	Homo sapiens human - (species)	Published - Accepted by Curator
CYP6AB3	Xenobiotic resistance (imperatorin)	Coding, SNP	Depressaria pastinacella (species)	Intraspecific	Candidate Gene	Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007) Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]	GP00000204	CYP6AB3 Q7YZS3	Physiology	Ala92Val (and potentiallly 4 other a.a. substitutions)	Depressaria pastinacella (species)	Depressaria pastinacella (species)	CYP6AB3	Depressaria pastinacella (species)	Published - Accepted by Curator
CYP6AY1	Xenobiotic resistance (imidacloprid; buprofezin)	Cis-regulatory, Unknown	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Pang R; Li Y; Dong Y ; et al. (2014) Identification of promoter polymorphisms in the cytochrome P450 CYP6AY1 linked with insecticide resi[...]	GP00002399	CYP6AY1 A0A1L1VFS3	Physiology	CYP6AY1 is expressed at a higher level in a field-collected BPH strain that is highly resistant to both imidacloprid and buprofezin. Polymorphism in the promoter region associated with various levels of resistance.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	CYP6AY1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6B1	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio polyxenes black swallowtail - (species)	Interspecific	Candidate Gene	Li W; Schuler MA; Berenbaum MR (2003) Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Sp[...]	GP00000205	CYP6B1 Q04552	Physiology Physiology	Ile484Phe and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio polyxenes black swallowtail - (species)	CYP6B1	Papilio polyxenes black swallowtail - (species)	Published - Accepted by Curator
CYP6B4	Xenobiotic resistance Host plant specialization	Coding, SNP	Papilio glaucus eastern tiger swallowtail - (species)	Intergeneric or Higher	Candidate Gene	Mao W; Schuler MA; Berenbaum MR (2007) Cytochrome P450s in Papilio multicaudatus and the transition from oligophagy to polyphagy in the Pap[...]	GP00000206	CYP6B4 Q27902	Physiology Physiology	Lys484Ser and probably other a.a. substitutions	Nymphalidae brushfoots - (family)	Papilio glaucus eastern tiger swallowtail - (species)	CYP6B4	Papilio glaucus eastern tiger swallowtail - (species)	Published - Accepted by Curator
CYP6BG1	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Plutella xylostella diamondback moth - (species) D	Intraspecific	Candidate Gene	Li X; Shan C; Li F ; et al. (2019) Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resista[...] 1 Additional References Mallott M; Hamm S; Troczka BJ (2019) A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]	GP00002064	CYP6BG1 A0A222NX20	Physiology	promoters tested in luciferase assays	Plutella xylostella diamondback moth - (species)	Plutella xylostella diamondback moth - (species) D	CYP6BG1	Plutella xylostella diamondback moth - (species)	Published - Accepted by Curator
CYP6CM1	Xenobiotic resistance (insecticide; imidacloprid)	Cis-regulatory, SNP	Bemisia tabaci (species) D	Intraspecific	Candidate Gene	Karunker I; Benting J; Lueke B ; et al. (2008) Over-expression of cytochrome P450 CYP6CM1 is associated with high resistance to imidacloprid in the[...]	GP00002608	A0A6C0PTH9	Physiology	three single-nucleotide polymorphic (SNP) markers in the intron region of CYP6CM1 that discriminate between the resistant and susceptible CYP6CM1 alleles	Bemisia tabaci (species)	Bemisia tabaci (species) D	CYP6CM1	Bemisia tabaci (species)	Published - Accepted by Curator
CYP6CY3	Xenobiotic resistance (insecticide; neonicotinoid; host plant)	Cis-regulatory, Insertion	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Zimmer CT; Riveron JM ; et al. (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift. 1 Additional References Bass C; Zimmer CT; Riveron JM (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift.	GP00001474	CYP6CY3 V5SQ25	Physiology	Expansion of a AC dinucleotide microsatellite (from 15 to 48 repeat units) in the promoter 198 bp upstream of the start codon that enhances gene expression	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	CYP6CY3	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
CYP6CY3-CYP6CY4	Xenobiotic resistance (insecticide; neonicotinoid; host plant)	Gene Amplification, Insertion	Myzus persicae green peach aphid - (species) D	Intraspecific	Candidate Gene	Bass C; Zimmer CT; Riveron JM ; et al. (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift. 3 Additional References Puinean AM; Foster SP; Oliphant L (2010) Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides [...] Bass C; Zimmer CT; Riveron JM (2013) Gene amplification and microsatellite polymorphism underlie a recent insect host shift. Singh KS; Troczka BJ; Duarte A (2020) The genetic architecture of a host shift: An adaptive walk protected an aphid and its endosymbiont f[...]	GP00001473	CYP6CY3 V5SQ25	Physiology	gene amplification (from 2 to 14-100 copies) - CYP6CY3 and neighboring gene CYP6CY4 are duplicated in M. p. nicotianae as a large amplicon of ~325 kb creating characteristic breakpoints identifying the region. CYP6CY4 and CYP6CY3 are highly effective at metabolizing nicotine to its nontoxic metabolite cotinine.	Myzus persicae green peach aphid - (species)	Myzus persicae green peach aphid - (species) D	CYP6CY3-CYP6CY4	Myzus persicae green peach aphid - (species)	Published - Accepted by Curator
CYP6D1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Musca domestica house fly - (species) D	Intraspecific	Candidate Gene	Gao J; Scott JG (2006) Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the hou[...]	GP00002118	CYP6D1 Q27698	Physiology	15 bp insertion which disrupts a putative mdGfi-1 binding site in the CYP6D1v1 promoter. mdGfi-1 is a negative regulator of transcription so this leads to increased expression of CYP6D1	Musca domestica house fly - (species)	Musca domestica house fly - (species) D	CYP6D1	Musca domestica house fly - (species)	Published - Accepted by Curator
cyp6d2	Xenobiotic resistance (chemotherapeutic agent, camptothecin)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Thomas AM; Hui C; South A ; et al. (2013) Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]	GP00001983	Cyp6g2 Q9V675	Physiology	G>C in CATAGgtaagga...caagCTCT so that intron 3 is not spliced and the codon GCT (spanning the intron) is transformed into CCT. The splicing is defective and intron 3 is transcribed and results in a stop codon and a protein truncated from its native C terminal part.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	cyp6d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6d2	Xenobiotic resistance (chemotherapeutic agent, camptothecin)	Coding, SNP	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Candidate Gene	Thomas AM; Hui C; South A ; et al. (2013) Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]	GP00001984	Cyp6g2 Q9V675	Physiology	N438T (A22652974C) and N439T (A22652978G) - exact causing mutation(s) not identified - semiquantitative RT-PCR revealed that this mutant produces little to no Cyp6d2 transcript. The mutation is thus also cis-regulatory.	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	cyp6d2	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, SNP	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002472	cyp6er1 A0A2I8B6P1	Physiology	T318S substitution results in a marked (20-fold) and significant increase in resistance compared to the wild-type susceptible variant.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, Deletion	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002473	cyp6er1 A0A2I8B6P1	Physiology	Deletion of Pro377. This provides a more moderate but significant 4.5-fold increase in resistance.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Coding, Complex Change	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002474	cyp6er1 A0A2I8B6P1	Physiology	A375del+A376G	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6ER1	Xenobiotic resistance (insecticide; imidacloprid)	Cis-regulatory, Unknown	Nilaparvata lugens brown planthopper - (species) D	Intraspecific	Candidate Gene	Zimmer CT; Garrood WT; Singh KS ; et al. (2018) Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]	GP00002475	cyp6er1 A0A2I8B6P1	Physiology	A significant (up to 9.5-fold) increase in expression driven by the promoter of CYP6ER1vA was observed in comparison to all other promoter variants. This suggests that cis-acting elements in the region upstream of CYP6ER1vA are responsible for the high expression of this variant in BPH populations across Southeast Asia.	Nilaparvata lugens brown planthopper - (species)	Nilaparvata lugens brown planthopper - (species) D	CYP6ER1	Nilaparvata lugens brown planthopper - (species)	Published - Accepted by Curator
CYP6FU1	Xenobiotic resistance (insecticide; deltamethrin)	Cis-regulatory, Unknown	Laodelphax striatellus small brown planthopper - (species) D	Intraspecific	Candidate Gene	Pu J; Sun H; Wang J ; et al. (2016) Multiple cis-acting elements involved in up-regulation of a cytochrome P450 gene conferring resistan[...]	GP00002117	CYP6FU1 A0A1S5R631	Physiology	Four cis-acting elements were identified whose influence on up-regulation was much more pronounced in combination than when present singly.	Laodelphax striatellus small brown planthopper - (species)	Laodelphax striatellus small brown planthopper - (species) D	CYP6FU1	Laodelphax striatellus small brown planthopper - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	4 Mutations: Insertion	Drosophila melanogaster fruit fly - (species) D	Intraspecific	Linkage Mapping	Chung H; Bogwitz MR; McCart C ; et al. (2007) Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]	GP00000207	Cyp6g1 Q9V674	Physiology	4 mutations	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species) D	cyp6g1	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Schlenke TA; Begun DJ (2004) Strong selective sweep associated with a transposon insertion in Drosophila simulans.	GP00002019	Cyp6g1 Q9V674	Physiology	insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D	cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
cyp6g1	Xenobiotic resistance (insecticide)	Cis-regulatory, Insertion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013) Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]	GP00002020	Cyp6g1 Q9V674	Physiology	insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene	Drosophila simulans (species)	Drosophila simulans (species) D	cyp6g1	Drosophila simulans (species)	Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)	Xenobiotic resistance (insecticide)	Cis-regulatory, Unknown	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Candidate Gene	Riveron JM; Irving H; Ndula M ; et al. (2013) Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...] 1 Additional References Mugenzi LMJ; Menze BD; Tchouakui M (2019) Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy ag[...]	GP00000208	CYP2C9 P11712	Physiology	Cis-regulatory variation in CYP6P9b gene	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9 cluster (CYP6P9a and CYP6P9b)	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP6P9; CYP6P4 cluster	Xenobiotic resistance (insecticide)	5 Mutations:	Anopheles funestus African malaria mosquito - (species) D	Intraspecific	Linkage Mapping	Wondji CS; Irving H; Morgan J ; et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...] 2 Additional References Weedall GD; Mugenzi LMJ; Menze BD (2019) A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing i[...] Wondji CS; Hearn J; Irving H (2022) RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ h[...]	GP00000209	Q2YH43	Physiology	5 mutations	Anopheles funestus African malaria mosquito - (species)	Anopheles funestus African malaria mosquito - (species) D	CYP6P9; CYP6P4 cluster	Anopheles funestus African malaria mosquito - (species)	Published - Accepted by Curator
CYP79D15	Toxicity levels (cyanogenic glucoside)	Gene Loss, Deletion N	Trifolium repens white clover - (species) D	Intraspecific	Linkage Mapping	Olsen KM; Hsu SC; Small LL (2008) Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...] 1 Additional References Olsen KM; Kooyers NJ; Small LL (2013) Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (T[...]	GP00000211	CYP79D15 B2Y2T9	Physiology	Gene deletion N	Trifolium repens white clover - (species)	Trifolium repens white clover - (species) D	CYP79D15	Trifolium repens white clover - (species)	Published - Accepted by Curator
CYP81F2	Glucosinolate content Herbivore resistance (aphids)	Cis-regulatory, Unknown	Arabidopsis thaliana thale cress - (species)	Intraspecific	Linkage Mapping	Pfalz M; Vogel H; Kroymann J (2009) The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole gluco[...]	GP00000212	CYP81F2 Q9LVD6	Physiology Physiology	unknown	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species)	CYP81F2	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
CYP9A	Xenobiotic resistance (insecticide; deltamethrin)	Gene Amplification, Insertion	Spodoptera frugiperda fall armyworm - (species)	Intraspecific	Association Mapping	Gimenez S; Abdelgaffar H; Goff GL ; et al. (2020) Adaptation by copy number variation increases insecticide resistance in the fall armyworm.	GP00002476		Physiology	In sensitive alleles the gene cluster is composed of 12 CYP9A genes and two alcohol dehydrogenase genes. All 30 resistant alleles have two copies of this unit while 28 and 6 alleles of the sensitive individuals had one and two copies; respectively.	Spodoptera frugiperda fall armyworm - (species)	Spodoptera frugiperda fall armyworm - (species)	CYP9A	Spodoptera frugiperda fall armyworm - (species)	Published - Accepted by Curator
CYP9A186	Xenobiotic resistance (insecticide; avermectin; emamectin benzoate; abamectin)	Coding, SNP	Spodoptera exigua beet armyworm - (species) D	Intraspecific	Linkage Mapping	Zuo Y; Shi Y; Zhang F ; et al. (2021) Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in[...]	GP00002393	CYP9A186 A0A8E4AAI2	Physiology	Heterologous expression and in vitro functional assays further confirm that a natural substitution (F116V) found in the substrate recognition site 1 (SRS1) of the CYP9A186 protein results in enhanced metabolism of EB and abamectin	Spodoptera exigua beet armyworm - (species)	Spodoptera exigua beet armyworm - (species) D	CYP9A186	Spodoptera exigua beet armyworm - (species)	Published - Accepted by Curator
CYP9J26	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Intraspecific	Candidate Gene	Bariami V; Jones CM; Poupardin R ; et al. (2012) Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]	GP00002606	CYP9J Q8T4S7	Physiology	CYP9J26 gene amplified about 6–7 times	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	CYP9J26	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
CYP9M6	Xenobiotic resistance (insecticide)	Gene Amplification, Insertion	Aedes aegypti yellow fever mosquito - (species) D	Experimental Evolution	Candidate Gene	Kasai S; Komagata O; Itokawa K ; et al. (2014) Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insens[...] 1 Additional References Smith LB; Kasai S; Scott JG (2016) Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human dis[...]	GP00002448	CYP9M6 X5ICI6	Physiology	CYP9M6 has the capability to metabolize permethrin and is over expressed in the resistant strain partially due to gene amplification. The average copy number of the CYP9M9 gene is 4.6-fold more than the standard strain based on qPCR.	Aedes aegypti yellow fever mosquito - (species)	Aedes aegypti yellow fever mosquito - (species) D	CYP9M6	Aedes aegypti yellow fever mosquito - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)	Coding, SNP	Plasmopara viticola (species) D	Intraspecific	Candidate Gene	Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007) At least two origins of fungicide resistance in grapevine downy mildew populations.	GP00002041	UQCRFS1 P47985	Physiology	Gly143Ala G1256C	Plasmopara viticola (species)	Plasmopara viticola (species) D	cytochrome b	Plasmopara viticola (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)	Coding, SNP	Plasmopara viticola (species) D	Intraspecific	Candidate Gene	Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007) At least two origins of fungicide resistance in grapevine downy mildew populations.	GP00002042	UQCRFS1 P47985	Physiology	Gly143Ala G1256C	Plasmopara viticola (species)	Plasmopara viticola (species) D	cytochrome b	Plasmopara viticola (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; myxothiazol)	Coding, SNP	Chlamydomonas reinhardtii (species) D	Intraspecific	Candidate Gene	Bennoun P; Delosme M; Kück U (1991) Mitochondrial genetics of Chlamydomonas reinhardtii: resistance mutations marking the cytochrome b g[...]	GP00002043	UQCRFS1 P47985	Physiology	F129L	Chlamydomonas reinhardtii (species)	Chlamydomonas reinhardtii (species) D	cytochrome b	Chlamydomonas reinhardtii (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	2 Mutations: Coding SNP	Mycena galopus (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002044	UQCRFS1 P47985	Physiology	2 mutations	Mycena viridimarginata (species)	Mycena galopus (species) D	cytochrome b	Mycena galopus (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	2 Mutations: Coding SNP	Strobilurus tenacellus (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002045	UQCRFS1 P47985	Physiology	2 mutations	Mycena viridimarginata (species)	Strobilurus tenacellus (species) D	cytochrome b	Strobilurus tenacellus (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)	Coding, SNP	Schizosaccharomyces pombe fission yeast - (species) D	Interspecific	Candidate Gene	Kraiczy P; Haase U; Gencic S ; et al. (1996) The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]	GP00002046	UQCRFS1 P47985	Physiology	N261D	Saccharomyces cerevisiae baker's yeast - (species)	Schizosaccharomyces pombe fission yeast - (species) D	cytochrome b	Schizosaccharomyces pombe fission yeast - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (insecticide ; bifenazate)	2 Mutations: Coding SNP	Tetranychus urticae two-spotted spider mite - (species) D	Interspecific	Candidate Gene	Van Leeuwen T; Vanholme B; Van Pottelberge S ; et al. (2008) Mitochondrial heteroplasmy and the evolution of insecticide resistance: non-Mendelian inheritance in[...]	GP00002599	UQCRFS1 P47985	Physiology	2 mutations	Tetranychus urticae two-spotted spider mite - (species)	Tetranychus urticae two-spotted spider mite - (species) D	cytochrome b	Tetranychus urticae two-spotted spider mite - (species)	Published - Accepted by Curator
cytochrome b	Xenobiotic resistance (insecticide ; bifenazate)	2 Mutations: Coding SNP	Panonychus citri citrus red mite - (species) D	Interspecific	Candidate Gene	Van Leeuwen T; Van Nieuwenhuyse P; Vanholme B ; et al. (2011) Parallel evolution of cytochrome b mediated bifenazate resistance in the citrus red mite Panonychus [...]	GP00002600	UQCRFS1 P47985	Physiology	2 mutations	Panonychus citri citrus red mite - (species)	Panonychus citri citrus red mite - (species) D	cytochrome b	Panonychus citri citrus red mite - (species)	Published - Accepted by Curator
cytochrome c oxidase (COX7A)	Fertility Lifespan Locomotor activity	Coding, Deletion	Drosophila simulans (species) D	Intraspecific	Candidate Gene	Melvin RG; Katewa SD; Ballard JW (2008) A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...] 1 Additional References Ballard JW; Melvin RG (2011) Early life benefits and later life costs of a two amino acid deletion in Drosophila simulans.	GP00001980	COX7A Q9VHS2	Physiology Physiology Physiology	Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.	Drosophila simulans (species)	Drosophila simulans (species) D	cytochrome c oxidase (COX7A)	Drosophila simulans (species)	Published - Accepted by Curator
D14 (KAI2 paralog)	Seed dormancy (strigolactone responsiveness)	Coding, Unknown	Arabidopsis thaliana thale cress - (species) D	Intergeneric or Higher	Candidate Gene	Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015) PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]	GP00000213	D14 Q10QA5	Physiology	Ligand-binding pocket tuning	Spermatophyta (no rank)	Arabidopsis thaliana thale cress - (species) D	D14 (KAI2 paralog)	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
Darkener of apricot (Doa)	Lifespan	Unknown, Unknown	Drosophila melanogaster fruit fly - (species)	Intraspecific	Association Mapping	Hoedjes KM; Kostic H; Keller L ; et al. (2022) Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity.	GP00002662	Doa P49762	Physiology	unknown	Drosophila melanogaster fruit fly - (species)	Drosophila melanogaster fruit fly - (species)	Darkener of apricot (Doa)	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
DCAF17	Hair Length	Unknown, Unknown	Sus scrofa pig - (species) D	Domesticated	Association Mapping	Ai H; Fang X; Yang B ; et al. (2015) Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequen[...]	GP00001570	DCAF17 I3LQF0	Physiology		Sus scrofa pig - (species)	Sus scrofa pig - (species) D	DCAF17	Sus scrofa pig - (species)	Published - Accepted by Curator
DEEPER ROOTING 1	Drought tolerance Root growth	Coding, Deletion N	Oryza sativa rice - (species) D	Domesticated	Linkage Mapping	Uga Y; Sugimoto K; Ogawa S ; et al. (2013) Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought condition[...]	GP00000215	Dro1 Q69P88	Physiology Morphology	1bp deletion within exon 4 N	Oryza sativa rice - (species)	Oryza sativa rice - (species) D	DEEPER ROOTING 1	Oryza sativa rice - (species)	Published - Accepted by Curator
Delta-1-pyrroline-5-carboxylate synthase A	Drought response (drought-induced proline accumulation)	2 Mutations: Coding	Arabidopsis thaliana thale cress - (species) D	Intraspecific	Linkage Mapping	Kesari R; Lasky JR; Villamor JG ; et al. (2012) Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation[...]	GP00001280	P5CSA P54887	Physiology	2 mutations	Arabidopsis thaliana thale cress - (species)	Arabidopsis thaliana thale cress - (species) D	Delta-1-pyrroline-5-carboxylate synthase A	Arabidopsis thaliana thale cress - (species)	Published - Accepted by Curator
dentin sialophosphoprotein (DSPP)	Tooth absence (no enamel production)	Coding, Deletion N	Gallus gallus chicken - (species) D	Intergeneric or Higher	Candidate Gene	Sire JY; Delgado SC; Girondot M (2008) Hen's teeth with enamel cap: from dream to impossibility.	GP00001936	DSPP Q9NZW4	Physiology	synteny of the corresponding region - only the N-terminal region of DSPP is present in the genome - 1-bp deletion in exon one leading to a reading frame shift were this sequence to be translated N	Paleosuchus palpebrosus Cuvier's dwarf caiman - (species)	Gallus gallus chicken - (species) D	dentin sialophosphoprotein (DSPP)	Gallus gallus chicken - (species)	Published - Accepted by Curator
DEP1 (DENSE AND ERECT PANICLES 1)	Nitrogen use (metabolism)	Coding, SNP	Oryza sativa Japonica Group Japanese rice - (no rank)	Domesticated	Linkage Mapping	Sun H; Qian Q; Wu K ; et al. (2014) Heterotrimeric G proteins regulate nitrogen-use efficiency in rice.	GP00001376	P0046G12.12-1 Q67UU9	Physiology	p.Cys105Tyr affecting affinity interaction between the GGL domain of DEP1 and RGB1 subunit	Oryza sativa Indica Group long-grained rice - (no rank)	Oryza sativa Japonica Group Japanese rice - (no rank)	DEP1 (DENSE AND ERECT PANICLES 1)	Oryza sativa Japonica Group Japanese rice - (no rank)	Published - Accepted by Curator
desatF	Pheromone production	Cis-regulatory, Unknown	Drosophila melanogaster fruit fly - (species)	Interspecific	Candidate Gene	Legendre A; Miao XX; Da Lage JL ; et al. (2008) Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and court[...] 1 Additional References Shirangi TR; Dufour HD; Williams TM (2009) Rapid evolution of sex pheromone-producing enzyme expression in Drosophila.	GP00000219	desatF A7DZ97	Physiology	Enrichment/gain of DSX binding sites	Drosophila (subgenus)	Drosophila melanogaster fruit fly - (species)	desatF	Drosophila melanogaster fruit fly - (species)	Published - Accepted by Curator
desatF	Pheromone production	Cis-regulatory, Deletion	Drosophila (subgenus) D	Interspecific	Candidate Gene	Shirangi TR; Dufour HD; Williams TM ; et al. (2009) Rapid evolution of sex pheromone-producing enzyme expression in Drosophila.	GP00000220	desatF A7DZ97	Physiology	Inactivation of DSX-binding site	Drosophila takahashii (species)	Drosophila (subgenus) D