18-wheeler
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sackton TB; Clark AG (2006)
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
GP00000001
18w
A1ZBR2
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
18-wheeler
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ABC transporter pvmrp1
Xenobiotic resistance (multiresistance to antimalarial drugs)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001486
PVX_097025
A5KCN4
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species)
ABC transporter pvmrp1
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Indel
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00000002
ABCA2
A0A0S0G7V0
Physiology
65bp indel in exon16 inducing a frameshift N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
ABCA2
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Deletion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00000003
ABCA2
A0A0S0G7V0
Physiology
5bp deletion inducing a frameshift N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
ABCA2
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00000004
ABCA2
A0A0S0G7V0
Physiology
5bp (GAATA) nucleotide duplication inducing a frameshift N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
ABCA2
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Yang X; Chen W; Song X ; et al. (2019)
Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.
GP00002054
ABCA2
A0A0S0G7V0
Physiology
insertion of a transposon Tntransib (2581 bp) in ABCA2 which changes splicing sites in the transcript and lead to an indel in the coding region: change of 1551VETLAHALGFLRHLDKR1567 into 1551AHWGK- LYGSNTQN1563 N
Trichoplusia ni
cabbage looper - (species)
Trichoplusia ni
cabbage looper - (species) D
ABCA2
Trichoplusia ni
cabbage looper - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Deletion
N
Helicoverpa punctigera
(species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00002056
ABCA2
A0A0S0G7V0
Physiology
14bp deletion resulting in missense mutations. N
Helicoverpa punctigera
(species)
Helicoverpa punctigera
(species) D
ABCA2
Helicoverpa punctigera
(species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Candidate Gene
Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018)
ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]
GP00002057
ABCA2
A0A0S0G7V0
Physiology
loss of exon 6 caused by alternative splicing N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
ABCA2
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab)
Coding,
Insertion
N
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Yang X; Chen W; Song X ; et al. (2019)
Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.
GP00002467
ABCA2
Q9BZC7
Physiology
insertion of a 2581-bp transposon Tntransib in ABCA2. This insertion disrupts splicing sites and leads to indels in the protein sequence. CRISPR ABCA2 mutants are highly resistant to Cry2Ab. N
Trichoplusia ni
cabbage looper - (species)
Trichoplusia ni
cabbage looper - (species) D
ABCA2
Trichoplusia ni
cabbage looper - (species)
Published - Accepted by Curator
ABCB1
Xenobiotic resistance (insecticide; Bt Cry3Aa toxin)
Coding,
Deletion
N
Chrysomela tremula
(species) D
Intraspecific
Candidate Gene
Pauchet Y; Bretschneider A; Augustin S ; et al. (2016)
A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle[...]
GP00002466
ABCB1
P08183
Physiology
a four-base-pair deletion at position 1561 introducing a frame shift with a premature stop codon leading to loss of the TpM1 transporter motif as well as the complete second transmembrane domain N
Chrysomela tremula
(species)
Chrysomela tremula
(species) D
ABCB1
Chrysomela tremula
(species)
Published - Accepted by Curator
Abcb4
Biliary Phospholipid Level (low)
Coding,
Unknown
N
Cavia porcellus
domestic guinea pig - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000008
Abcb4
P21440
Physiology
pseudogenization N
Mammalia
mammals - (class)
Cavia porcellus
domestic guinea pig - (species)
Abcb4
Cavia porcellus
domestic guinea pig - (species)
Published - Accepted by Curator
Abcb4
Biliary Phospholipid Level (low)
Coding,
Unknown
N
Equus caballus
horse - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000009
Abcb4
P21440
Physiology
pseudogenization N
Mammalia
mammals - (class)
Equus caballus
horse - (species)
Abcb4
Equus caballus
horse - (species)
Published - Accepted by Curator
ABCB4
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Bariami V; Jones CM; Poupardin R ; et al. (2012)
Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]
GP00002607
Abcb4
P21440
Physiology
ABCB4 gene amplified about 6–7 times
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
ABCB4
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
ABCB7
Iron metabolism
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001379
ABCB7
O75027
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
ABCB7
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
ABCC11
Apocrine secretion (ear wax type ; axillary odor)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Yoshiura K; Kinoshita A; Ishida T ; et al. (2006)
A SNP in the ABCC11 gene is the determinant of human earwax type.
1 Additional References
GP00000010
ABCC11
Q96J66
Physiology
1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ABCC11
Homo sapiens
human - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide)
Coding,
Insertion
Bombyx mori
domestic silkworm - (species) D
Domesticated
Linkage Mapping
Atsumi S; Miyamoto K; Yamamoto K ; et al. (2012)
Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin[...]
GP00000011
ABCC2
A0A0E3ZDK3
Physiology
1a.a. insertion at codon 234 (Tyr)
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
ABCC2
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Gahan LJ; Pauchet Y; Vogel H ; et al. (2010)
An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]
GP00000012
ABCC2
A0A0E3ZDK3
Physiology
22bp deletion N
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
ABCC2
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011)
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.
GP00000013
ABCC2
A0A0E3ZDK3
Physiology
30bp deletion N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
ABCC2
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt Cry1Ac)
Unknown,
Unknown
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011)
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.
GP00000014
ABCC2
A0A0E3ZDK3
Physiology
Not identified
Trichoplusia ni
cabbage looper - (species)
Trichoplusia ni
cabbage looper - (species) D
ABCC2
Trichoplusia ni
cabbage looper - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt toxins)
Coding,
Deletion
N
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Linkage Mapping
Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014)
ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]
GP00001439
Physiology
About 500 nt genomic deletion over 2 exons involving 246 nt coding 82aa N
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
ABCC2
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt toxins)
Coding,
Complex Change
N
Spodoptera frugiperda
fall armyworm - (species) D
Intraspecific
Candidate Gene
Banerjee R; Hasler J; Meagher R ; et al. (2017)
Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm[...]
1 Additional References
GP00002461
MRP1
H8YF43
Physiology
A nine-base deletion (position 39–47) and a two-base insertion (GC at position 2218) lead to a frameshift and the occurrence of a premature stop codon. The truncated protein is 746 amino acids whereas the ABCC2 of the susceptible strain encodes a protein of 1349 amino acids. N
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species) D
ABCC2
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt toxins)
Coding,
Complex Change
N
Spodoptera frugiperda
fall armyworm - (species) D
Intraspecific
Candidate Gene
Boaventura D; Ulrich J; Lueke B ; et al. (2020)
Molecular characterization of Cry1F resistance in fall armyworm, Spodoptera frugiperda from Brazil.
GP00002462
MRP1
H8YF43
Physiology
two mutations in the extracellular loop 4 (ECL4) of ABCC2: a deletion of two amino acids (GY) at positions 788 and 789 and the change of a proline to either lysine or arginine at position 799. Expression of mutated ABCC2 in insect cells confirmed the role of these mutations in toxin binding. N
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species) D
ABCC2
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
ABCG2
Milk yield
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Cohen-Zinder M; Seroussi E; Larkin DM ; et al. (2005)
Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chr[...]
1 Additional References
GP00000015
Abcg2
Q7TMS5
Physiology
Tyr581Ser
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
ABCG2
Bos taurus
cattle - (species)
Published - Accepted by Curator
ABCG2
Milk yield
Unknown,
Unknown
Ovis aries
sheep - (species)
Domesticated
Candidate Gene
García-Fernández M; Gutiérrez-Gil B; Sánchez JP ; et al. (2011)
The role of bovine causal genes underlying dairy traits in Spanish Churra sheep.
GP00000016
Abcg2
Q7TMS5
Physiology
unknown
Ovis aries
sheep - (species)
Ovis aries
sheep - (species)
ABCG2
Ovis aries
sheep - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
Homininae
(subfamily)
Intraspecific
Candidate Gene
Yamamoto F; Hakomori S (1990)
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...]
1 Additional References
GP00000017
ABO
P16442
Physiology
Gly268 (group A) <-> Ala (group B)
Homininae
(subfamily)
Homininae
(subfamily)
ABO histo blood group glycosyltransferase
Homininae
(subfamily)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
Homininae
(subfamily)
Intraspecific
Candidate Gene
Yamamoto F; Hakomori S (1990)
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...]
1 Additional References
GP00000018
ABO
P16442
Physiology
Leu266 (group A) <-> Met (group B)
Homininae
(subfamily)
Homininae
(subfamily)
ABO histo blood group glycosyltransferase
Homininae
(subfamily)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Yamamoto F; Hakomori S (1990)
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...]
1 Additional References
GP00000019
ABO
P16442
Physiology
1bp deletion (258G) resulting in frameshift N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993)
Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele.
1 Additional References
GP00000020
ABO
P16442
Physiology
Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function)
two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
Insertion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005)
New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes.
1 Additional References
GP00000021
ABO
P16442
Physiology
1bp insertion resulting in premature stop codon N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
N
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005)
New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes.
1 Additional References
GP00000022
ABO
P16442
Physiology
1bp change resulting in stop codon N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
Unknown
Pan troglodytes
chimpanzee - (species)
Intraspecific
Candidate Gene
Kermarrec N; Roubinet F; Apoil PA ; et al. (1999)
Comparison of allele O sequences of the human and non-human primate ABO system.
GP00000023
ABO
P16442
Physiology
Uncertain; possibly 9bp deletion resultin in 3a.a. deletion
Pan troglodytes
chimpanzee - (species)
Pan troglodytes
chimpanzee - (species)
ABO histo blood group glycosyltransferase
Pan troglodytes
chimpanzee - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Unknown,
Unknown
Pan troglodytes
chimpanzee - (species)
Intraspecific
Candidate Gene
Kermarrec N; Roubinet F; Apoil PA ; et al. (1999)
Comparison of allele O sequences of the human and non-human primate ABO system.
GP00000024
ABO
P16442
Physiology
unknown
Pan troglodytes
chimpanzee - (species)
Pan troglodytes
chimpanzee - (species)
ABO histo blood group glycosyltransferase
Pan troglodytes
chimpanzee - (species)
Published - Accepted by Curator
ACD6 = ACCELERATED CELL DEATH 6
Plant size
Pathogen resistance (plant microbes)
Herbivore resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Todesco M; Balasubramanian S; Hu TT ; et al. (2010)
Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana.
1 Additional References
GP00000025
ACD6
Q8LPS2
Physiology
Physiology
Physiology
Various
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ACD6 = ACCELERATED CELL DEATH 6
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; cyclic ketoenol)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Lueke B; Douris V; Hopkinson JE ; et al. (2020)
Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated[...]
1 Additional References
GP00002513
ACC
Q7JV23
Physiology
A2083V
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
acetyl-CoA carboxylase (ACC)
Bemisia tabaci
(species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; spiromesifen)
Coding,
SNP
Trialeurodes vaporariorum
greenhouse whitefly - (species) D
Intraspecific
Candidate Gene
Karatolos N; Williamson MS; Denholm I ; et al. (2012)
Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid repla[...]
1 Additional References
GP00002556
ACC
Q7JV23
Physiology
E645K
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Trialeurodes vaporariorum
greenhouse whitefly - (species) D
acetyl-CoA carboxylase (ACC)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; spirotetramat)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021)
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]
GP00002616
ACC
Q7JV23
Physiology
a single non-synonymous mutation (gCt > gTt) resulting in an alanine to valine substitution in a highly conserved region of the ACC carboxyltransferase (CT) domain
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
acetyl-CoA carboxylase (ACC)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; spirotetramat)
Coding,
SNP
Caenorhabditis elegans
(species) D
Experimental Evolution
Linkage Mapping
Guest M; Kriek N; Flemming AJ (2020)
Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.
GP00002617
ACC
Q7JV23
Physiology
A1559V
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
acetyl-CoA carboxylase (ACC)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; spirotetramat)
Coding,
SNP
Caenorhabditis elegans
(species) D
Experimental Evolution
Linkage Mapping
Guest M; Kriek N; Flemming AJ (2020)
Studies of an insecticidal inhibitor of acetyl-CoA carboxylase in the nematode C. elegans.
GP00002618
ACC
Q7JV23
Physiology
A1847V
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
acetyl-CoA carboxylase (ACC)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles albimanus
(species) D
Intraspecific
Candidate Gene
Weill M; Malcolm C; Chandre F ; et al. (2004)
The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]
GP00000026
Ace
P07140
Physiology
G119S
Anopheles albimanus
(species)
Anopheles albimanus
(species) D
Acetylcholinesterase (Ace-1)
Anopheles albimanus
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Weill M; Lutfalla G; Mogensen K ; et al. (2003)
Comparative genomics: Insecticide resistance in mosquito vectors.
GP00000027
Ace
P07140
Physiology
G119S
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Weill M; Lutfalla G; Mogensen K ; et al. (2003)
Comparative genomics: Insecticide resistance in mosquito vectors.
GP00000028
Ace
P07140
Physiology
Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Acetylcholinesterase (Ace-1)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Weill M; Lutfalla G; Mogensen K ; et al. (2003)
Comparative genomics: Insecticide resistance in mosquito vectors.
GP00000029
Ace
P07140
Physiology
Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Acetylcholinesterase (Ace-1)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex tritaeniorhynchus
(species) D
Intraspecific
Candidate Gene
Alout H; Berthomieu A; Cui F ; et al. (2007)
Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]
1 Additional References
GP00000030
Ace
P07140
Physiology
F331W
Culex tritaeniorhynchus
(species)
Culex tritaeniorhynchus
(species) D
Acetylcholinesterase (Ace-1)
Culex tritaeniorhynchus
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex vishnui
(species) D
Intraspecific
Candidate Gene
Alout H; Berthomieu A; Cui F ; et al. (2007)
Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]
GP00000031
Ace
P07140
Physiology
G119S
Culex vishnui
(species)
Culex vishnui
(species) D
Acetylcholinesterase (Ace-1)
Culex vishnui
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
3 Mutations:
Aphis gossypii
cotton aphid - (species)
Intraspecific
Candidate Gene
Shang Q; Pan Y; Fang K ; et al. (2014)
Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...]
4 Additional References
GP00000036
Ace
P07140
Physiology
3 mutations
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species)
Acetylcholinesterase (Ace-1)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Assogba BS; Milesi P; Djogbénou LS ; et al. (2016)
The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]
1 Additional References
GP00001372
Ace
P07140
Physiology
Strict tandem duplication of 203kb encompassing 12 genes ; ace1 heterogeneous gene duplication (susceptible G119 and resistant S119 copies)
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Anopheles gambiae
African malaria mosquito - (species)
Intraspecific
Candidate Gene
Assogba BS; Milesi P; Djogbénou LS ; et al. (2016)
The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]
GP00001373
Ace
P07140
Physiology
Strict tandem 3 times duplication of 203kb encompassing 12 genes with partial internal deletion of 97kb in the third copy - ace1 homogeneous gene duplications (all 3 copies S119 resistant)
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species)
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Assogba BS; Milesi P; Djogbénou LS ; et al. (2016)
The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]
GP00001374
Ace
P07140
Physiology
Strict tandem 5 times duplication of 203kb encompassing 12 genes - ace1 homogeneous gene duplications (all 5 copies S119 resistant)
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
2 Additional References
GP00002013
Ace
P07140
Physiology
A201S
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Nabeshima T; Kozaki T; Tomita T ; et al. (2003)
An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of[...]
GP00002015
Ace
P07140
Physiology
Ser431Phe (position 331 in mature Torpedo protein)
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
Acetylcholinesterase (Ace-1)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Jiang X; Qu M; Denholm I ; et al. (2009)
Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]
GP00002453
Ace
P07140
Physiology
an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance
Chilo suppressalis
striped riceborer - (species)
Chilo suppressalis
striped riceborer - (species) D
Acetylcholinesterase (Ace-1)
Chilo suppressalis
striped riceborer - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Lee DW; Choi JY; Kim WT ; et al. (2007)
Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.).
3 Additional References
GP00002454
Ace
P07140
Physiology
2 mutations
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
Acetylcholinesterase (Ace-1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Mavridis K; Papapostolou KM; Ilias A ; et al. (2022)
Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]
GP00002512
Ace
P07140
Physiology
F331W
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
Acetylcholinesterase (Ace-1)
Bemisia tabaci
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002571
Ace
P07140
Physiology
S119G
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
2 Additional References
GP00002572
Ace
P07140
Physiology
G328A
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Khajehali J; Van Leeuwen T; Grispou M ; et al. (2010)
Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...]
1 Additional References
GP00002573
Ace
P07140
Physiology
F331W
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002574
Ace
P07140
Physiology
D128E
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species)
Intraspecific
Candidate Gene
Li F; Han Z (2004)
Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...]
3 Additional References
GP00002577
Ace
P07140
Physiology
A201S
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species)
Acetylcholinesterase (Ace-1)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Cydia pomonella
codling moth - (species) D
Intraspecific
Candidate Gene
Cassanelli S; Reyes M; Rault M ; et al. (2006)
Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...]
1 Additional References
GP00002580
Ace
P07140
Physiology
F399V = F290V
Cydia pomonella
codling moth - (species)
Cydia pomonella
codling moth - (species) D
Acetylcholinesterase (Ace-1)
Cydia pomonella
codling moth - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Alout H; Berthomieu A; Hadjivassilis A ; et al. (2007)
A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipi[...]
1 Additional References
GP00002581
Ace
P07140
Physiology
F290V
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Acetylcholinesterase (Ace-1)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Intraspecific
Candidate Gene
Chen MH; Han ZJ; Qiao XF ; et al. (2007)
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...]
1 Additional References
GP00002587
Ace
P07140
Physiology
S329(228)P
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Acetylcholinesterase (Ace-1)
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012
)
Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...]
1 Additional References
GP00002589
Ace
P07140
Physiology
F330S
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
Acetylcholinesterase (Ace-1)
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012
)
Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...]
1 Additional References
GP00002590
Ace
P07140
Physiology
F331H
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
Acetylcholinesterase (Ace-1)
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus kanzawai
(species) D
Intraspecific
Candidate Gene
Aiki Yasuhiko; Kozaki Toshinori; Mizuno Hiroshi ; et al. (2005
)
Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resist[...]
1 Additional References
GP00002591
Ace
P07140
Physiology
F331W
Tetranychus kanzawai
(species)
Tetranychus kanzawai
(species) D
Acetylcholinesterase (Ace-1)
Tetranychus kanzawai
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002592
Ace
P07140
Physiology
F331C
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus evansi
red spider mite - (species) D
Intraspecific
Candidate Gene
Carvalho Renato; Yang Yihua; Field Linda M ; et al. (2012
)
Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 [...]
1 Additional References
GP00002593
Ace
P07140
Physiology
F331W/Y
Tetranychus evansi
red spider mite - (species)
Tetranychus evansi
red spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus evansi
red spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Laodelphax striatellus
small brown planthopper - (species) D
Intraspecific
Candidate Gene
Zhang Yueliang; Li Shuo; Xu Lu ; et al. (2013
)
Overexpression of carboxylesterase-1 and mutation (F439H) of acetylcholinesterase-1 are associated w[...]
1 Additional References
GP00002594
Ace
P07140
Physiology
F331H
Laodelphax striatellus
small brown planthopper - (species)
Laodelphax striatellus
small brown planthopper - (species) D
Acetylcholinesterase (Ace-1)
Laodelphax striatellus
small brown planthopper - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitobion avenae
English grain aphid - (species) D
Intraspecific
Candidate Gene
Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007
)
Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...]
1 Additional References
GP00002595
Ace
P07140
Physiology
L336S
Sitobion avenae
English grain aphid - (species)
Sitobion avenae
English grain aphid - (species) D
Acetylcholinesterase (Ace-1)
Sitobion avenae
English grain aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Zhang LJ; Jing YP; Li XH ; et al. (2015)
Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...]
1 Additional References
GP00002598
Ace
P07140
Physiology
A441G
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
Acetylcholinesterase (Ace-1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000040
Ace
P07140
Physiology
Gly365Ala
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000041
Ace
P07140
Physiology
Gly262Val
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000043
Ace
P07140
Physiology
Gly262Ala
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
4 Mutations:
Coding
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Mutero A; Pralavorio M; Bride JM ; et al. (1994)
Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.
2 Additional References
GP00002011
Ace
P07140
Physiology
4 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Mutero A; Pralavorio M; Bride JM ; et al. (1994)
Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.
GP00002012
Ace
P07140
Physiology
Ile199Thr (position 129 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Menozzi P; Shi MA; Lougarre A ; et al. (2004)
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]
GP00002016
Ace
P07140
Physiology
Gly368Ala (position 328 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes - GGC>GCC
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Anthony NM; Brown JK; Markham PG ; et al. (1995
)
Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...]
1 Additional References
GP00002565
Ace
P07140
Physiology
Phe392Trp mutation located in the acyl pocket of the active site gorge and recently shown to confer OP insensitivity in Culex tritaeniorhynchus
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
Acetylcholinesterase (Ace-2)
Bemisia tabaci
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Menozzi P; Shi MA; Lougarre A ; et al. (2004)
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]
GP00002568
Ace
P07140
Physiology
E73G
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Li Fei; Han Zhaojun (2004
)
Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...]
1 Additional References
GP00002569
Ace
P07140
Physiology
F78L
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
Acetylcholinesterase (Ace-2)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Menozzi P; Shi MA; Lougarre A ; et al. (2004)
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]
GP00002570
Ace
P07140
Physiology
E81K
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Kozaki T; Shono T; Tomita T ; et al. (2001)
Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point [...]
1 Additional References
GP00002575
Ace
P07140
Physiology
I129V
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bactrocera oleae
olive fruit fly - (species) D
Intraspecific
Candidate Gene
Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002)
Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]
1 Additional References
GP00002576
Ace
P07140
Physiology
I129V
Bactrocera oleae
olive fruit fly - (species)
Bactrocera oleae
olive fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Bactrocera oleae
olive fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Temeyer KB; Li AY; Lohmeyer KH ; et al. (2008)
Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae).
1 Additional References
GP00002578
Ace
P07140
Physiology
G227A
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
Acetylcholinesterase (Ace-2)
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Zhu KY; Lee SH; Clark JM (1996)
A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]
1 Additional References
GP00002579
Ace
P07140
Physiology
S238G
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Acetylcholinesterase (Ace-2)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
1 Additional References
GP00002582
Ace
P07140
Physiology
F290Y
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Cochliomyia hominivorax
primary screw-worm - (species) D
Intraspecific
Candidate Gene
da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011)
Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]
GP00002583
Ace
P07140
Physiology
F466Y
Cochliomyia hominivorax
primary screw-worm - (species)
Cochliomyia hominivorax
primary screw-worm - (species) D
Acetylcholinesterase (Ace-2)
Cochliomyia hominivorax
primary screw-worm - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Intraspecific
Candidate Gene
Chen MH; Han ZJ; Qiao XF ; et al. (2007)
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...]
1 Additional References
GP00002585
Ace
P07140
Physiology
F368(290)L
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Acetylcholinesterase (Ace-2)
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Intraspecific
Candidate Gene
Chen MH; Han ZJ; Qiao XF ; et al. (2007)
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...]
1 Additional References
GP00002586
Ace
P07140
Physiology
V435(356)A
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Acetylcholinesterase (Ace-2)
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Ceratitis capitata
Mediterranean fruit fly - (species) D
Intraspecific
Candidate Gene
Magaña C; Hernández-Crespo P; Brun-Barale A ; et al. (2008)
Mechanisms of resistance to malathion in the medfly Ceratitis capitata.
1 Additional References
GP00002588
Ace
P07140
Physiology
Gly328Ala
Ceratitis capitata
Mediterranean fruit fly - (species)
Ceratitis capitata
Mediterranean fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Ceratitis capitata
Mediterranean fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex tritaeniorhynchus
(species) D
Intraspecific
Candidate Gene
Nabeshima T; Mori A; Kozaki T ; et al. (2004)
An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Ja[...]
1 Additional References
GP00002596
Ace
P07140
Physiology
F331W - F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge
Culex tritaeniorhynchus
(species)
Culex tritaeniorhynchus
(species) D
Acetylcholinesterase (Ace-2)
Culex tritaeniorhynchus
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitobion avenae
English grain aphid - (species) D
Intraspecific
Candidate Gene
Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007
)
Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...]
1 Additional References
GP00002597
Ace
P07140
Physiology
W435R
Sitobion avenae
English grain aphid - (species)
Sitobion avenae
English grain aphid - (species) D
Acetylcholinesterase (Ace-2)
Sitobion avenae
English grain aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Bactrocera oleae
olive fruit fly - (species) D
Intraspecific
Candidate Gene
Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002)
Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]
GP00000037
Ace
P07140
Physiology
2 mutations
Bactrocera oleae
olive fruit fly - (species)
Bactrocera oleae
olive fruit fly - (species) D
Acetylcholinesterase (Ace)
Bactrocera oleae
olive fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
Deletion
Bactrocera oleae
olive fruit fly - (species) D
Intraspecific
Candidate Gene
Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008)
A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...]
1 Additional References
GP00000038
Ace
P07140
Physiology
9bp deletion of three glutamine residues at positions 642_644
Bactrocera oleae
olive fruit fly - (species)
Bactrocera oleae
olive fruit fly - (species) D
Acetylcholinesterase (Ace)
Bactrocera oleae
olive fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Zhu KY; Lee SH; Clark JM (1996)
A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]
GP00000039
Ace
P07140
Physiology
Ser->Gly at position 238 of the Torpedo AChE
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Acetylcholinesterase (Ace)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000042
Ace
P07140
Physiology
Val180Leu
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000044
Ace
P07140
Physiology
Phe327Tyr
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Bactrocera dorsalis
oriental fruit fly - (species) D
Intraspecific
Candidate Gene
Hsu JC; Haymer DS; Wu WJ ; et al. (2006)
Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]
GP00000045
Ace
P07140
Physiology
2 mutations
Bactrocera dorsalis
oriental fruit fly - (species)
Bactrocera dorsalis
oriental fruit fly - (species) D
Acetylcholinesterase (Ace)
Bactrocera dorsalis
oriental fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Zhu KY; Lee SH; Clark JM (1996)
A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]
GP00002014
Ace
P07140
Physiology
Ser>Gly (238 is the corresponding position in Torpedo)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Acetylcholinesterase (Ace)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
adenosine deaminase (AgADA)
Pathogen resistance (parasite)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Li J; Wang X; Zhang G ; et al. (2013)
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]
GP00001463
ADA
P00813
Physiology
c.C427T p.R143C
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
adenosine deaminase (AgADA)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
AEP2
Hybrid Incompatibility (F2 sterility)
Coding,
SNP
Saccharomyces bayanus
(species)
Domesticated
Linkage Mapping
Lee HY; Chou JY; Cheong L ; et al. (2008)
Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast speci[...]
GP00000051
AEP2
P22136
Physiology
The region between aa 348 and aa 496 plays a critical role. When this region was further dissected in the constructs H-AEP2-bcb and H-AEP2-m3; both failed to restore respiration in the Chromosome 13 line. This result suggests that multiple critical mutations have occurred during the functional diversification of Sc-AEP2 and Sb-AEP2.
Exact causing mutation(s) not determined
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces bayanus
(species)
AEP2
Saccharomyces bayanus
(species)
Published - Accepted by Curator
AFGP multigene - antifreeze glycoproteins
Anti-freezing
Coding,
Unknown
Dissostichus mawsoni
Antarctic toothfish - (species)
Intergeneric or Higher
Candidate Gene
Chen L; DeVries AL; Cheng CH (1997)
Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
2 Additional References
GP00000052
afgp8
P24856
Physiology
multiple modifications of a pancreatic; secreted trypsinogen; notably via multiplications of small tri-peptidic repeats
Teleostei
teleost fishes - (infraclass)
Dissostichus mawsoni
Antarctic toothfish - (species)
AFGP multigene - antifreeze glycoproteins
Dissostichus mawsoni
Antarctic toothfish - (species)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (coat)
Lifespan
2 Mutations:
Coding
N
Ovis aries
sheep - (species) D
Intraspecific
Linkage Mapping
Gratten J; Pilkington JG; Brown EA ; et al. (2010)
The genetic basis of recessive self-colour pattern in a wild sheep population.
1 Additional References
GP00001356
Asip
Q03288
Morphology
Physiology
2 mutations
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
Agouti (ASIP)
Ovis aries
sheep - (species)
Published - Accepted by Curator
AHR
Xenobiotic resistance (polycyclic aromatic hydrocarbons; TCDD)
Coding,
SNP
Mus musculus
house mouse - (species)
Domesticated
Linkage Mapping
Poland A; Palen D; Glover E (1994)
Analysis of the four alleles of the murine aryl hydrocarbon receptor.
GP00001810
Ahr
P30561
Physiology
alanine at position 375 mutated into valine; decreases the affinity 4-fold
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
AHR
Mus musculus
house mouse - (species)
Published - Accepted by Curator
AHR
Xenobiotic resistance (dioxins; polycyclic aromatic hydrocarbons; TCDD)
2 Mutations:
Coding
SNP
Sterna hirundo hirundo
(subspecies) D
Intergeneric or Higher
Candidate Gene
Karchner SI; Franks DG; Kennedy SW ; et al. (2006)
The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon recep[...]
1 Additional References
GP00001811
Ahr
P30561
Physiology
2 mutations
Gallus gallus
chicken - (species)
Sterna hirundo hirundo
(subspecies) D
AHR
Sterna hirundo hirundo
(subspecies)
Published - Accepted by Curator
AHR
Xenobiotic resistance (TCDD)
Coding,
SNP
N
Rattus norvegicus
Norway rat - (species) D
Intraspecific
Linkage Mapping
Tuomisto JT; Viluksela M; Pohjanvirta R ; et al. (1999)
The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resista[...]
2 Additional References
GP00001813
Ahr
P30561
Physiology
point mutation in the exon/intron 10 boundary in AHR genomic structure that leads to use of 3 alternative cryptic splice sites; potentially creating 3 alternative transcripts and 2 protein products. At the protein level the mutation leads to a total loss of either 43 or 38 amino acids (with altered sequence for the last seven amino acids in the latter case) toward the carboxyl-terminal end in the trans-activation domain of the AhR. H/W rats also harbor a point mutation in exon 10 that will cause a Val-to-Ala substitution in codon 497, but this occurs in a variable region of the AhR N
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species) D
AHR
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
1 Additional References
GP00001806
Ahr
P30561
Physiology
70 kb deletion that removes parts of the two genes AHR1a and AHR2a N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AHR2
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
1 Additional References
GP00001807
Ahr
P30561
Physiology
45 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 5 of AHR2a to exon 4 of AHR1a) N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AHR2
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
1 Additional References
GP00001808
Ahr
P30561
Physiology
83 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 11 of AHR2a to exon 6 of AHR1a) N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AHR2
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution; polychlorinated biphenyls; PCBs)
Coding,
Deletion
N
Microgadus tomcod
Atlantic tomcod - (species) D
Intraspecific
Candidate Gene
Wirgin I; Roy NK; Loftus M ; et al. (2011)
Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.
GP00001809
Ahr
P30561
Physiology
6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain N
Microgadus tomcod
Atlantic tomcod - (species)
Microgadus tomcod
Atlantic tomcod - (species) D
AHR2
Microgadus tomcod
Atlantic tomcod - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002669
Ahr
P30561
Physiology
70 kb deletion that removes parts of the two genes AHR1a and AHR2a N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
AHR2
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
AIM22
F2 lethality
Coding,
SNP
Saccharomyces bayanus
(species)
Interspecific
Linkage Mapping
Chou JY; Hung YS; Lin KH ; et al. (2010)
Multiple molecular mechanisms cause reproductive isolation between three yeast species.
GP00000073
AIM22
P47051
Physiology
Several candidate non-synonymous changes - exact causing mutation(s) unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces bayanus
(species)
AIM22
Saccharomyces bayanus
(species)
Published - Accepted by Curator
AIP
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
GP00001812
Aip
O08915
Physiology
exact mutation(s) unknown - very good candidate gene according to association mapping and knowledge about the physiology N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AIP
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AIP
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002670
Aip
O08915
Physiology
exact mutation(s) unknown - very good candidate gene according to Fst and knowledge about the physiology N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
AIP
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
6 Mutations:
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Choudhary M; Laurie CC (1991)
Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...]
4 Additional References
GP00001962
Adh
P00334
Physiology
6 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
4 Mutations:
Drosophila yakuba
(species)
Interspecific
Candidate Gene
Loehlin DW; Ames JR; Vaccaro K ; et al. (2019)
A major role for noncoding regulatory mutations in the evolution of enzyme activity.
GP00001963
Adh
P00334
Physiology
4 mutations
Drosophila santomea
(species)
Drosophila yakuba
(species)
alcohol dehydrogenase (Adh)
Drosophila yakuba
(species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
4 Mutations:
Drosophila erecta
(species)
Interspecific
Candidate Gene
Loehlin DW; Ames JR; Vaccaro K ; et al. (2019)
A major role for noncoding regulatory mutations in the evolution of enzyme activity.
GP00001964
Adh
P00334
Physiology
4 mutations
Drosophila orena
(species)
Drosophila erecta
(species)
alcohol dehydrogenase (Adh)
Drosophila erecta
(species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
5 Mutations:
Drosophila virilis
(species) D
Interspecific
Candidate Gene
Loehlin DW; Ames JR; Vaccaro K ; et al. (2019)
A major role for noncoding regulatory mutations in the evolution of enzyme activity.
GP00001965
Adh
P00334
Physiology
5 mutations
Drosophila americana
(species)
Drosophila virilis
(species) D
alcohol dehydrogenase (Adh)
Drosophila virilis
(species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Vigue C; Sofer W (1974)
Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.
GP00001988
Adh
P00334
Physiology
Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Strand DJ; McDonald JF (1989)
Insertion of a copia element 5' to the Drosophila melanogaster alcohol dehydrogenase gene (adh) is a[...]
GP00001989
Adh
P00334
Physiology
insertion of a complete 5.2kb copia retroviral-like transposable element 240 bp upstream from the distal (adult) adh transcriptional start site
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Coding,
Insertion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Freeth AL; Gibson JB; Wilks AV (1990)
Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...]
1 Additional References
GP00001990
Adh
P00334
Physiology
eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Gibson JB; Wilks AV; Agrotis A (1992)
Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]
GP00001991
Adh
P00334
Physiology
438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)
Xenobiotic resistance (alcohol)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Li H; Mukherjee N; Soundararajan U ; et al. (2007)
Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]
1 Additional References
GP00000077
ADH1B
P00325
Physiology
Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
alcohol dehydrogenase (ADH1B)
Homo sapiens
human - (species)
Published - Accepted by Curator
Aldehyde dehydrogenase (Aldh)
Xenobiotic resistance (alcohol)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Fry JD; Donlon K; Saweikis M (2008)
A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selectio[...]
GP00002007
Aldh
Q9VLC5
Physiology
L479F C9391311T
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Aldehyde dehydrogenase (Aldh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Alk / Starch Synthase II
Grain cooking texture
4 Mutations:
Coding
SNP
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Umemoto T; Yano M; Satoh H ; et al. (2002)
Mapping of a gene responsible for the difference in amylopectin structure between japonica-type and [...]
2 Additional References
GP00000078
SSII-3
Q0DDE3
Physiology
4 mutations
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Alk / Starch Synthase II
Oryza sativa
rice - (species)
Published - Accepted by Curator
Allantoin permease DAL4
Nitrogen use (growth rate on allantoin)
Coding,
Indel
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001503
DAL4
Q04895
Physiology
c.1201delA a single nucleotide frameshifting insertion (deletion?) N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Allantoin permease DAL4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Allantoinase DAL1
Nitrogen use (growth rate on allantoin)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001502
DAL1
P32375
Physiology
c.415C>T p.P139S predicted to be strongly detrimental
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Allantoinase DAL1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ALMT gene cluster
Metal tolerance
Gene Amplification,
Indel
Secale cereale
rye - (species)
Domesticated
Linkage Mapping
Collins NC; Shirley NJ; Saeed M ; et al. (2008)
An ALMT1 gene cluster controlling aluminum tolerance at the Alt4 locus of rye (Secale cereale L).
GP00000079
ALMT1
Q76LB1
Physiology
Copy number Variant
Secale cereale
rye - (species)
Secale cereale
rye - (species)
ALMT gene cluster
Secale cereale
rye - (species)
Published - Accepted by Curator
ALMT1
Metal tolerance
Cis-regulatory,
Unknown
Triticum aestivum
bread wheat - (species)
Domesticated
Linkage Mapping
Raman H; Zhang K; Cakir M ; et al. (2005)
Molecular characterization and mapping of ALMT1, the aluminium-tolerance gene of bread wheat (Tritic[...]
2 Additional References
GP00000080
ALMT1
Q76LB1
Physiology
multiple regulatory changes
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
ALMT1
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
ALS
Xenobiotic resistance (herbicides; ALS inhibitor)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt William L; Tranel Patrick J (2007
)
Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)
GP00001893
ALS
P17597
Physiology
W574L
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
ALS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
ALS
Xenobiotic resistance (herbicides; ALS inhibitor)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt William L; Tranel Patrick J (2007
)
Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)
GP00001894
ALS
P17597
Physiology
S653N
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
ALS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
ALS
Xenobiotic resistance (herbicides; ALS inhibitor)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt William L; Tranel Patrick J (2007
)
Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)
GP00001895
ALS
P17597
Physiology
S653T
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
ALS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
ameloblastin (AMBN)
Tooth absence (no enamel production)
Gene Loss,
Deletion
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001934
AMBN
Q9NP70
Physiology
synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
ameloblastin (AMBN)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
ameloblastin (AMBN)
Tooth absence (no enamel production)
Coding,
Unknown
N
Mysticeti
baleen whales - (suborder) D
Intergeneric or Higher
Candidate Gene
Deméré TA; McGowen MR; Berta A ; et al. (2008)
Morphological and molecular evidence for a stepwise evolutionary transition from teeth to baleen in [...]
1 Additional References
GP00001938
AMBN
Q9NP70
Physiology
multiple frameshift mutations N
Cetacea
whales - (order)
Mysticeti
baleen whales - (suborder) D
ameloblastin (AMBN)
Mysticeti
baleen whales - (suborder)
Published - Accepted by Curator
amelogenin (AMEL)
Tooth absence (no enamel production)
3 Mutations:
Coding
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001933
Amelx
P63277
Physiology
3 mutations
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
amelogenin (AMEL)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
amelogenin (AMEL)
Tooth absence (no enamel production)
Coding,
Unknown
N
Mysticeti
baleen whales - (suborder) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Cheng J ; et al. (2011)
Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]
GP00001937
Amelx
P63277
Physiology
J. Gatesy 2010 unpublished data cited in the main reference N
Cetacea
whales - (order)
Mysticeti
baleen whales - (suborder) D
amelogenin (AMEL)
Mysticeti
baleen whales - (suborder)
Published - Accepted by Curator
Amhr2
Sex determination (female vs male)
Coding,
SNP
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Intraspecific
Linkage Mapping
Kamiya T; Kai W; Tasumi S ; et al. (2012)
A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, [...]
GP00002147
AMHR2
Q16671
Physiology
His/Asp384 heterozygous males have reduced Amrh2 activity due to decreased activity of the kinase signaling domain
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Amhr2
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Published - Accepted by Curator
Aminopeptidase N (APN)
Xenobiotic resistance (insecticide; Bt Cry2Ac toxin)
Coding,
Deletion
N
Helicoverpa armigera
cotton bollworm - (species) D
Experimental Evolution
Candidate Gene
Yang Y; Zhu YC; Ottea J ; et al. (2010)
Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacil[...]
GP00002463
apn
Q9VFX3
Physiology
deletion removing 22 amino acids. The mutant form failed to bind Cry1Ac unlike the full-length susceptible form. N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Aminopeptidase N (APN)
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ammonium transporter 2;1
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001431
AMT2
Q9M6N7
Physiology
seven aa substitutions
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
ammonium transporter 2;1
Arabidopsis arenosa
(species)
Published - Accepted by Curator
AMN1
Cell separation
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Yvert G; Brem RB; Whittle J ; et al. (2003)
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.
GP00000082
AMN1
P38285
Physiology
D368V
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
AMN1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
AMPD1 (=CG32626)
Drug resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Kislukhin G; King EG; Walters KN ; et al. (2013)
The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.
GP00000083
AMPD1
P23109
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
AMPD1 (=CG32626)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]
Drug resistance
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Wessels JA; van der Kooij SM; le Cessie S ; et al. (2007)
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset[...]
GP00000084
AMPD1
P23109
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]
Homo sapiens
human - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Mus musculus
house mouse - (species) D
Domesticated
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001867
Amy1
P00687
Physiology
Copy Number Variation
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species) D
amylase
Mus musculus
house mouse - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Rattus norvegicus
Norway rat - (species) D
Domesticated
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001868
Amy1
P00687
Physiology
Copy Number Variation
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species) D
amylase
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Sus scrofa
pig - (species) D
Domesticated
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001869
Amy1
P00687
Physiology
Copy Number Variation
Sus scrofa
pig - (species)
Sus scrofa
pig - (species) D
amylase
Sus scrofa
pig - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Cebus capucinus
white-faced sapajou - (species) D
Intergeneric or Higher
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001870
Amy1
P00687
Physiology
3-4 copies of the amylase gene; which coincides with increased levels of amylase activity in saliva
Aotus trivirgatus
douroucouli - (species)
Callithrix jacchus
white-tufted-ear marmoset - (species)
Cebus capucinus
white-faced sapajou - (species) D
amylase
Cebus capucinus
white-faced sapajou - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Papio anubis
olive baboon - (species) D
Intergeneric or Higher
Candidate Gene
Pajic P; Pavlidis P; Dean K ; et al. (2019)
Independent amylase gene copy number bursts correlate with dietary preferences in mammals.
GP00001871
Amy1
P00687
Physiology
3-4 copies of the amylase gene; which coincides with increased levels of amylase activity in saliva
Cercocebus atys
sooty mangabey - (species)
Macaca mulatta
Rhesus monkey - (species)
Papio anubis
olive baboon - (species) D
amylase
Papio anubis
olive baboon - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Meles leucurus
Asian badger - (species) D
Intraspecific
Candidate Gene
Abduriyim Shamshidin; Nishita Yoshinori; Abramov AV ; et al. (2019
)
Variation in pancreatic amylase gene copy number among Eurasian badgers (Carnivora, Mustelidae, Mele[...]
GP00001907
Amy1
P00687
Physiology
Copy Number Variation varies between one and four in this species
Meles leucurus
Asian badger - (species)
Meles leucurus
Asian badger - (species) D
amylase
Meles leucurus
Asian badger - (species)
Published - Accepted by Curator
amylase 1 (AMY1)
Starch processing
Gene Amplification,
Insertion
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Perry GH; Dominy NJ; Claw KG ; et al. (2007)
Diet and the evolution of human amylase gene copy number variation.
2 Additional References
GP00000085
AMY1A
P04745
Physiology
Probably gene duplication
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
amylase 1 (AMY1)
Homo sapiens
human - (species)
Published - Accepted by Curator
amylase 2B (AMY2B)
Starch processing
Gene Amplification,
Insertion
Canis lupus familiaris
dog - (subspecies) D
Domesticated
Association Mapping
Axelsson E; Ratnakumar A; Arendt ML ; et al. (2013)
The genomic signature of dog domestication reveals adaptation to a starch-rich diet.
4 Additional References
GP00000086
LOC479922
L7N0N6
Physiology
Copy Number Variation
Canis lupus
gray wolf - (species)
Canis lupus familiaris
dog - (subspecies) D
amylase 2B (AMY2B)
Canis lupus familiaris
dog - (subspecies)
Published - Accepted by Curator
AOP2
Glucosinolate content
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001)
Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...]
2 Additional References
GP00000095
AOP2
Q945B5
Physiology
5bp deletion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AOP2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AOP3
Glucosinolate content
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001)
Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...]
2 Additional References
GP00000096
AOP3
Q9ZTA1
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AOP3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
apicoplast ribosomal protein S10
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001531
PF3D7_1460900.1
Q8IKM3
Physiology
p.Val127Met
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
apicoplast ribosomal protein S10
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
APJ1
Xenobiotic resistance (alcohol, ethanol)
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Swinnen S; Schaerlaekens K; Pais T ; et al. (2012)
Identification of novel causative genes determining the complex trait of high ethanol tolerance in y[...]
GP00000097
APJ1
P53940
Physiology
unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
APJ1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
APL1 cluster
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Riehle MM; Markianos K; Niaré O ; et al. (2006)
Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region.
1 Additional References
GP00000098
APL1A
L7RQU1
Physiology
Not identified
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
APL1 cluster
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
APOE (apolipoprotein E)
Aging
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Joshi PK; Fischer K; Schraut KE ; et al. (2016)
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
GP00000099
APOE
P02649
Physiology
Cys112Arg
Homo sapiens
human - (species)
Homo sapiens
human - (species)
APOE (apolipoprotein E)
Homo sapiens
human - (species)
Published - Accepted by Curator
APSR
Sulfate content (shoot)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007)
Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.
GP00000100
APR2
P92981
Physiology
A399E N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
APSR
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Aquaporin
Water transport (selective accumulation of water or glycerol)
Coding,
SNP
Polypedilum vanderplanki
sleeping chironomid - (species)
Interspecific
Candidate Gene
Finn RN; Chauvigné F; Stavang JA ; et al. (2015)
Insect glycerol transporters evolved by functional co-option and gene replacement.
GP00001421
AQP1
P29972
Physiology
p.His174Ala
Blattella germanica
German cockroach - (species)
Polypedilum vanderplanki
sleeping chironomid - (species)
Aquaporin
Polypedilum vanderplanki
sleeping chironomid - (species)
Published - Accepted by Curator
Aquaporin (AQY1)
Growth rate (environment-dependent)
2 Mutations:
Coding
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Linkage Mapping
Will JL; Kim HS; Clarke J ; et al. (2010)
Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]
1 Additional References
GP00001872
AQP1
P29972
Physiology
2 mutations
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Aquaporin (AQY1)
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Aquaporin (AQY1)
Growth rate (environment-dependent)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Candidate Gene
Will JL; Kim HS; Clarke J ; et al. (2010)
Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]
1 Additional References
GP00001873
AQP1
P29972
Physiology
aquaporin yeast 1 gene on chromosome 12 - A881 deletion renders AQY1 inactive - size of the deletion not indicated in the paper - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Aquaporin (AQY1)
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Aquaporin (AQY1)
Growth rate (environment-dependent)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Linkage Mapping
Will JL; Kim HS; Clarke J ; et al. (2010)
Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]
1 Additional References
GP00001874
AQP1
P29972
Physiology
aquaporin yeast 1 gene on chromosome 12 - 955-bp deletion that removes the first 106 bp of AQY1 and its upstream region - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Aquaporin (AQY1)
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Aquaporin (AQY2)
Growth rate (environment-dependent)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Linkage Mapping
Will JL; Kim HS; Clarke J ; et al. (2010)
Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]
1 Additional References
GP00001875
AQP1
P29972
Physiology
aquaporin yeast 2 gene on chromosome 11 - 11-bp deletion that creates a stop codon in the middle of the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Aquaporin (AQY2)
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Aquaporin (AQY2)
Growth rate (environment-dependent)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Candidate Gene
Will JL; Kim HS; Clarke J ; et al. (2010)
Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]
1 Additional References
GP00001876
AQP1
P29972
Physiology
aquaporin yeast 2 gene on chromosome 11 - deletion of nucleotide G at position 25 (G25) which creates a frameshift the AQY2 gene - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Aquaporin (AQY2)
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Aquaporin (AQY2)
Growth rate (environment-dependent)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Candidate Gene
Will JL; Kim HS; Clarke J ; et al. (2010)
Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisia[...]
GP00001877
AQP1
P29972
Physiology
aquaporin yeast 2 gene on chromosome 11 - G528 deletion which creates a frameshift the AQY2 gene - tested in assays - GenBank accession numbers for AQY1 and AQY2: GQ848552-74 and GQ870433-54 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Aquaporin (AQY2)
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
arginyl-transfer RNA synthetase (RARS)
Heat tolerance
Coding,
SNP
Anolis cristatellus
(species) D
Intraspecific
Association Mapping
Campbell-Staton SC; Winchell KM; Rochette NC ; et al. (2020)
Parallel selection on thermal physiology facilitates repeated adaptation of city lizards to urban he[...]
GP00002620
RARS2
Q5T160
Physiology
C>G threonine>serine at amino acid residue 558 of the RARS gene = adjacent to a predicted protein-binding region22 (AA556–557). There are four non-synonymous polymorphic sites within RARS. Only one shows a significant difference in allele frequency between forest and urban habitats across all populations.
Anolis cristatellus
(species)
Anolis cristatellus
(species) D
arginyl-transfer RNA synthetase (RARS)
Anolis cristatellus
(species)
Published - Accepted by Curator
ARHGAP15
Pathogen resistance (Trypanosoma)
Coding,
SNP
Bos taurus
cattle - (species) D
Domesticated
Linkage Mapping
Noyes H; Brass A; Obara I ; et al. (2011)
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]
GP00000103
Arhgap15
Q811M1
Physiology
H282P
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
ARHGAP15
Bos taurus
cattle - (species)
Published - Accepted by Curator
ARHGEF3
Hematopoiesis (mean blood platelet volume & blood platelet count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001605
ARHGEF3
Q9NR81
Physiology
T>C at the associated SNP that disrupts a conserved GATA motif. This variant overlaps with a common-myeloid progenitor (CMP-) and megakaryocyte-erythroid progenitor (MEP-) specific regulatory element that affects the transcription of ARHGEF3
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ARHGEF3
Homo sapiens
human - (species)
Published - Accepted by Curator
ARNT-1c
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002672
P27540NULL
Physiology
exact mutation(s) unknown - very good candidate gene according to high differentiation region on chromosome 8 and knowledge about the physiology. ARNT1c is a nuclear dimerization partner of aryl hydrocarbon receptor (AHR) required for activation of the xenobiotic response pathway. N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
ARNT-1c
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
ARNT-L2a
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002671
P27540NULL
Physiology
exact mutation(s) unknown - very good candidate gene according to high differentiation region on chromosome 10 and knowledge about the physiology. ARNT-L2a is a nuclear dimerization partner of aryl hydrocarbon receptor (AHR) required for activation of the xenobiotic response pathway. N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
ARNT-L2a
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
ASP1
Acetic acid production
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Marullo P; Aigle M; Bely M ; et al. (2007)
Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cere[...]
GP00000104
APS1
P35181
Physiology
Asp142His
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
ASP1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
asparagine synthetase (AS)
Silk yield
Unknown,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xiang H; Liu X; Li M ; et al. (2018)
The evolutionary road from wild moth to domestic silkworm.
1 Additional References
GP00002404
AsnS
Q7KTW9
Physiology
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
asparagine synthetase (AS)
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
AT5G41740/AT5G41750
Hybrid incompatibility (auto-immune necrosis)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Bomblies K; Lempe J; Epple P ; et al. (2007)
Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants.
GP00000105
MUF8.2
F4JYI4
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AT5G41740/AT5G41750
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtHKT1
Salt tolerance
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Rus A; Baxter I; Muthukumar B ; et al. (2006)
Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis.
1 Additional References
GP00000124
HKT1
Q84TI7
Physiology
725bp deletion of part of upstream repeat region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AtHKT1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtHKT1
Salt tolerance
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Rus A; Baxter I; Muthukumar B ; et al. (2006)
Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis.
1 Additional References
GP00000125
HKT1
Q84TI7
Physiology
687bp deletion of part of upstream repeat region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AtHKT1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtLURE1
Fertilization (pollen-tube attraction by egg)
Gene Amplification,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Interspecific
Candidate Gene
Takeuchi H; Higashiyama T (2012)
A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arab[...]
GP00000126
LURE1.1
Q4VP09
Physiology
Gene birth
Arabidopsis lyrata
(species)
Arabidopsis thaliana
thale cress - (species)
AtLURE1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ATP2B4
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Timmann C; Thye T; Vens M ; et al. (2012)
Genome-wide association study indicates two novel resistance loci for severe malaria.
GP00000127
ATP2B4
P23634
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ATP2B4
Homo sapiens
human - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001908
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
ATP4A
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001920
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
ATP4A
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001922
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
ATP4A
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
ATP4A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001928
ATP4A
P20648
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
ATP4A
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
3 Mutations:
Coding
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001909
ATP4B
P51164
Physiology
3 mutations
Monodelphis domestica
gray short-tailed opossum - (species)
Homo sapiens
human - (species)
Ornithorhynchus anatinus
platypus - (species) D
ATP4B
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Callorhinchus milii
elephant shark - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001916
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence N
Scyliorhinus canicula
smaller spotted catshark - (species)
Callorhinchus milii
elephant shark - (species) D
ATP4B
Callorhinchus milii
elephant shark - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001921
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
ATP4B
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001923
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
ATP4B
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
ATP4B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001929
ATP4B
P51164
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
ATP4B
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
ATR13
Pathogenicity
Coding,
SNP
Hyaloperonospora parasitica
(species)
Intraspecific
Linkage Mapping
Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004)
Host-parasite coevolutionary conflict between Arabidopsis and downy mildew.
1 Additional References
GP00000128
Atr13
Q5G7K8
Physiology
Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown
Hyaloperonospora parasitica
(species)
Hyaloperonospora parasitica
(species)
ATR13
Hyaloperonospora parasitica
(species)
Published - Accepted by Curator
ATXN1
Body fat distribution (attenuation)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001552
ATXN1
P54253
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ATXN1
Homo sapiens
human - (species)
Published - Accepted by Curator
AZI1
Root growth (root growth responses to low zinc conditions)
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Bouain N; Satbhai SB; Korte A ; et al. (2018)
Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition.
GP00001769
AZI1
Q9SU35
Physiology
exact causing mutation(s) unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AZI1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
B4GALNT2
Fertility (increased ovulation rate)
Cis-regulatory,
Unknown
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Drouilhet L; Mansanet C; Sarry J ; et al. (2013)
The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GAL[...]
GP00001979
B4galnt2
Q09199
Physiology
candidate region to 197kb ; putative mutation (g.36938224T>A) in intron 7or (g.37034573A>G) 96 kb away in an intergenic region
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
B4GALNT2
Ovis aries
sheep - (species)
Published - Accepted by Curator
bab2
Fertility (ovariole number)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Green DA; Extavour CG (2012)
Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...]
1 Additional References
GP00000132
bab2
Q9W0K4
Physiology
unknown ; loss of function reduces ovariole number
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
bab2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
SNP
Glycine max
soybean - (species)
Domesticated
Linkage Mapping
Juwattanasomran R; Somta P; Chankaew S ; et al. (2011)
A SNP in GmBADH2 gene associates with fragrance in vegetable soybean variety "Kaori" and SNAP marker[...]
GP00000133
BADH2
Q84LK3
Physiology
1 amino-acid substitution in conserved enzymatic domain
Glycine max
soybean - (species)
Glycine max
soybean - (species)
BADH2
Glycine max
soybean - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Deletion
N
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Bradbury LM; Fitzgerald TL; Henry RJ ; et al. (2005)
The gene for fragrance in rice.
1 Additional References
GP00000134
BADH2
Q84LK3
Physiology
8bp deletion resulting in premature stop codon N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Shi Weiwei; Yang Yi; Chen Saihua ; et al. (2008
)
Discovery of a new fragrance allele and the development of functional markers for the breeding of fr[...]
1 Additional References
GP00001772
BADH2
Q84LK3
Physiology
7-bp deletion in exon 2 resulting in premature stop codon N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001773
BADH2
Q84LK3
Physiology
2-bp deletion in exon 1 resulting in premature stop codon N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Insertion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001774
BADH2
Q84LK3
Physiology
insertion of 1 bp (T) in exon 10 N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001775
BADH2
Q84LK3
Physiology
G>T substitution in exon 10 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001776
BADH2
Q84LK3
Physiology
G>T substitution in exon 14 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001777
BADH2
Q84LK3
Physiology
C>T substitution in exon 13 - need to check the sequence to check if this mutation is nonsense or nonsynonymous N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001778
BADH2
Q84LK3
Physiology
1-bp deletion in exon 10 - causes a frameshift N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Insertion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001779
BADH2
Q84LK3
Physiology
1-bp insertion (G) in exon 14 N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BADH2
Fragrance
Coding,
Insertion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Kovach MJ; Calingacion MN; Fitzgerald MA ; et al. (2009)
The origin and evolution of fragrance in rice (Oryza sativa L.).
GP00001780
BADH2
Q84LK3
Physiology
3-bp insertion (TAT) in exon 13 - causes a frameshift N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
BADH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
BAK1
Hematopoiesis (blood platelet count)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001616
BAK1
Q16611
Physiology
A>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
BAK1
Homo sapiens
human - (species)
Published - Accepted by Curator
BBS9 (+ BMPER)
Growth rate
Coding,
Deletion
N
Sus scrofa domesticus
domestic pig - (subspecies) D
Domesticated
Association Mapping
Derks MFL; Lopes MS; Bosse M ; et al. (2018)
Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes[...]
GP00002341
Bbs9
Q811G0
Physiology
212kb deletion resulting in truncated BBS9 protein and recessive loss of neighbor gene expression BMPER N
Sus scrofa domesticus
domestic pig - (subspecies)
Sus scrofa domesticus
domestic pig - (subspecies) D
BBS9 (+ BMPER)
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
BCMA
Glucosinolate content
Herbivore resistance
3 Mutations:
Boechera stricta
(species)
Intraspecific
Linkage Mapping
Prasad KV; Song BH; Olson-Manning C ; et al. (2012)
A gain-of-function polymorphism controlling complex traits and fitness in nature.
GP00000136
J9QWI9
Physiology
Physiology
3 mutations
Boechera stricta
(species)
Boechera stricta
(species)
BCMA
Boechera stricta
(species)
Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2
Carotenoid content (yellow serum)
Coding,
SNP
N
Bos taurus
cattle - (species) D
Domesticated
Linkage Mapping
Berry SD; Davis SR; Beattie EM ; et al. (2009)
Mutation in bovine beta-carotene oxygenase 2 affects milk color.
1 Additional References
GP00000138
BCO2
Q9BYV7
Physiology
c.306G>A ; p.W102* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
BCO2 = beta-carotene oxygenase 2
Bos taurus
cattle - (species)
Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2
Carotenoid content (yellow fat)
Coding,
SNP
N
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Våge DI; Boman IA (2010)
A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumula[...]
1 Additional References
GP00000140
BCO2
Q9BYV7
Physiology
g.21947481C>T ; c.196C>T ; p.Q66* N
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BCO2 = beta-carotene oxygenase 2
Ovis aries
sheep - (species)
Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2
Carotenoid content (yellow fat)
Coding,
Deletion
N
Oryctolagus cuniculus
rabbit - (species) D
Domesticated
Candidate Gene
Strychalski J; Brym P; Czarnik U ; et al. (2015)
A novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits.
GP00002152
BCO2
Q9BYV7
Physiology
AAT-deletion mutation at Asp codon 248 of the BCO2 gene located at the beginning of exon 6 which results in the removal of an Asp N
Oryctolagus cuniculus
rabbit - (species)
Oryctolagus cuniculus
rabbit - (species) D
BCO2 = beta-carotene oxygenase 2
Oryctolagus cuniculus
rabbit - (species)
Published - Accepted by Curator
benzoic acid/salicylic acid carboxyl methyltransferase (BSMT)
Fragrance
Cis-regulatory,
Unknown
Petunia axillaris
(species) D
Interspecific
Linkage Mapping
Amrad A; Moser M; Mandel T ; et al. (2016)
Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]
GP00001766
BSMT1
Q6XMI3
Physiology
Allele-specific expression in hybrids - de novo expression in P. axillaris
Petunia integrifolia subsp. inflata
(subspecies)
Petunia axillaris
(species) D
benzoic acid/salicylic acid carboxyl methyltransferase (BSMT)
Petunia axillaris
(species)
Published - Accepted by Curator
benzoyl-CoA:benzylalcohol/2-phenylethanol benzoyltransferase (BPBT)
Fragrance
Cis-regulatory,
Unknown
Petunia axillaris
(species) D
Interspecific
Linkage Mapping
Amrad A; Moser M; Mandel T ; et al. (2016)
Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]
GP00001765
BPBT
A0A172W606
Physiology
Allele-specific expression in hybrids - de novo expression in P. axillaris
Petunia integrifolia subsp. inflata
(subspecies)
Petunia axillaris
(species) D
benzoyl-CoA:benzylalcohol/2-phenylethanol benzoyltransferase (BPBT)
Petunia axillaris
(species)
Published - Accepted by Curator
beta-casein
Milk protein content (casein)
Coding,
SNP
Bos taurus
cattle - (species) D
Domesticated
Linkage Mapping
Gallinat JL; Qanbari S; Drögemüller C ; et al. (2013)
DNA-based identification of novel bovine casein gene variants.
GP00002025
CSN2
P02666
Physiology
g.87181619A>C c.245A>C p.H82P CAT>CCT
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
beta-casein
Bos taurus
cattle - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001263
BGLU6
Q682B4
Physiology
T-> A of a splice site at position 168 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001264
BGLU6
Q682B4
Physiology
1-bp deletion of a splice site at position 395 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001265
BGLU6
Q682B4
Physiology
GAG to stop codon TAG at position 913 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001266
BGLU6
Q682B4
Physiology
A deletion of one nucleotide in the seventh exon (BGLU6 CDS position 678) results in a premature stop codon in the accessions Bor-4, Se-0, Uod-1, and Zdr-1. premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001267
BGLU6
Q682B4
Physiology
GAG to stop codon TAG at position 1138 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Haemonchus contortus
barber pole worm - (species) D
Intraspecific
Candidate Gene
Kwa MS; Veenstra JG; Roos MH (1994)
Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...]
1 Additional References
GP00001785
TUB2
P02557
Physiology
Phe200Tyr
Haemonchus contortus
barber pole worm - (species)
Haemonchus contortus
barber pole worm - (species) D
beta-tubulin
Haemonchus contortus
barber pole worm - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Trichostrongylus colubriformis
(species) D
Intraspecific
Candidate Gene
Kwa MS; Veenstra JG; Roos MH (1994)
Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...]
1 Additional References
GP00001786
TUB2
P02557
Physiology
Phe200Tyr
Trichostrongylus colubriformis
(species)
Trichostrongylus colubriformis
(species) D
beta-tubulin
Trichostrongylus colubriformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Venturia inaequalis
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001788
TUB2
P02557
Physiology
Phe200Tyr
Venturia inaequalis
(species)
Venturia inaequalis
(species) D
beta-tubulin
Venturia inaequalis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001789
TUB2
P02557
Physiology
Phe200Tyr
D
beta-tubulin
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium italicum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001790
TUB2
P02557
Physiology
Phe200Tyr
Penicillium italicum
(species)
Penicillium italicum
(species) D
beta-tubulin
Penicillium italicum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium aurantiogriseum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001791
TUB2
P02557
Physiology
Phe200Tyr
Penicillium aurantiogriseum
(species)
Penicillium aurantiogriseum
(species) D
beta-tubulin
Penicillium aurantiogriseum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium aurantiogriseum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001792
TUB2
P02557
Physiology
Glu198Lys
Penicillium aurantiogriseum
(species)
Penicillium aurantiogriseum
(species) D
beta-tubulin
Penicillium aurantiogriseum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium viridicatum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001793
TUB2
P02557
Physiology
Glu198Lys
Penicillium viridicatum
(species)
Penicillium viridicatum
(species) D
beta-tubulin
Penicillium viridicatum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Clarireedia homoeocarpa
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001794
TUB2
P02557
Physiology
Glu1198Lys
Clarireedia homoeocarpa
(species)
Clarireedia homoeocarpa
(species) D
beta-tubulin
Clarireedia homoeocarpa
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Venturia inaequalis
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001795
TUB2
P02557
Physiology
Glu1198Lys
Venturia inaequalis
(species)
Venturia inaequalis
(species) D
beta-tubulin
Venturia inaequalis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Venturia inaequalis
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001796
TUB2
P02557
Physiology
Glu1198Ala
Venturia inaequalis
(species)
Venturia inaequalis
(species) D
beta-tubulin
Venturia inaequalis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001797
TUB2
P02557
Physiology
Glu1198Ala
D
beta-tubulin
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Monilinia fructicola
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001798
TUB2
P02557
Physiology
Glu1198Lys
Monilinia fructicola
(species)
Monilinia fructicola
(species) D
beta-tubulin
Monilinia fructicola
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium puberulum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001799
TUB2
P02557
Physiology
Glu1198Lys
Penicillium puberulum
(species)
Penicillium puberulum
(species) D
beta-tubulin
Penicillium puberulum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium puberulum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001800
TUB2
P02557
Physiology
Glu1198Ala
Penicillium puberulum
(species)
Penicillium puberulum
(species) D
beta-tubulin
Penicillium puberulum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium digitatum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001801
TUB2
P02557
Physiology
Glu1198Lys
Penicillium digitatum
(species)
Penicillium digitatum
(species) D
beta-tubulin
Penicillium digitatum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium expansum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001802
TUB2
P02557
Physiology
Glu1198Ala
Penicillium expansum
(species)
Penicillium expansum
(species) D
beta-tubulin
Penicillium expansum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium italicum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001803
TUB2
P02557
Physiology
Glu198Lys
Penicillium italicum
(species)
Penicillium italicum
(species) D
beta-tubulin
Penicillium italicum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Teladorsagia circumcincta
(species) D
Intraspecific
Candidate Gene
Elard L; Humbert JF (1999)
Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole[...]
GP00001815
TUB2
P02557
Physiology
Phe200Tyr
Teladorsagia circumcincta
(species)
Teladorsagia circumcincta
(species) D
beta-tubulin
Teladorsagia circumcincta
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Haemonchus contortus
barber pole worm - (species) D
Intraspecific
Candidate Gene
Prichard R; Oxberry M; Bounhas Y ; et al. (2000
)
Polymerisation and benzimidazole binding assays with recombinant α-and β-tubulins from Haemonchus co[...]
2 Additional References
GP00001816
TUB2
P02557
Physiology
Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus b-tubulin (produced in a prokaryote system)
Haemonchus contortus
barber pole worm - (species)
Haemonchus contortus
barber pole worm - (species) D
beta-tubulin
Haemonchus contortus
barber pole worm - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Cyathostoma
(genus) D
Intraspecific
Candidate Gene
Silvestre A; Cabaret J (2002)
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]
1 Additional References
GP00001817
TUB2
P02557
Physiology
Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus and S. cerevisiae b-tubulin (produced in a prokaryote system)
Cyathostoma
(genus)
Cyathostoma
(genus) D
beta-tubulin
Cyathostoma
(genus)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Neurospora crassa
(species) D
Intraspecific
Candidate Gene
Orbach MJ; Porro EB; Yanofsky C (1986)
Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurosp[...]
GP00001818
TUB2
P02557
Physiology
Phe167Tyr
Neurospora crassa
(species)
Neurospora crassa
(species) D
beta-tubulin
Neurospora crassa
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Teladorsagia circumcincta
(species) D
Intraspecific
Candidate Gene
Silvestre A; Cabaret J (2002)
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]
GP00001819
TUB2
P02557
Physiology
Phe167Tyr
Teladorsagia circumcincta
(species)
Teladorsagia circumcincta
(species) D
beta-tubulin
Teladorsagia circumcincta
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Haemonchus contortus
barber pole worm - (species) D
Intraspecific
Candidate Gene
Ghisi M; Kaminsky R; Mäser P (2007)
Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutatio[...]
GP00001820
TUB2
P02557
Physiology
Glu198Ala
Haemonchus contortus
barber pole worm - (species)
Haemonchus contortus
barber pole worm - (species) D
beta-tubulin
Haemonchus contortus
barber pole worm - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
GP00001821
TUB2
P02557
Physiology
Phe200Tyr
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
GP00001822
TUB2
P02557
Physiology
Phe200Tyr
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001823
TUB2
P02557
Physiology
E198A
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001824
TUB2
P02557
Physiology
E198G
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001825
TUB2
P02557
Physiology
E198K
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001826
TUB2
P02557
Physiology
E198A
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001827
TUB2
P02557
Physiology
E198G
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001828
TUB2
P02557
Physiology
E198Q
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001829
TUB2
P02557
Physiology
L240F
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001830
TUB2
P02557
Physiology
A185P - missense_variant_c.553G>C_3539974 – A185P N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001832
TUB2
P02557
Physiology
stop_gained_HIGH_c.1267C>T_3538394 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001833
TUB2
P02557
Physiology
Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001834
TUB2
P02557
Physiology
missense_variant_MODERATE_c.1210G>A_3538451 – D404N N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001835
TUB2
P02557
Physiology
Del_3539006_3539808 – 802bp deletion of coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001836
TUB2
P02557
Physiology
stop_gained_HIGH_c.1135A>T_3539335 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001837
TUB2
P02557
Physiology
stop_gained_HIGH_c.1112C>A_3539358 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001838
TUB2
P02557
Physiology
Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001839
TUB2
P02557
Physiology
Del_3539470_3539471 – 1bp deletion in coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001840
TUB2
P02557
Physiology
Del_3539507_3539514 – 7bp deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001841
TUB2
P02557
Physiology
Del_3539559_3539745 – 186 bp deletion in coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001842
TUB2
P02557
Physiology
Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001843
TUB2
P02557
Physiology
missense_variant_MODERATE_c.771G>A_3539699 – M257I N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001844
TUB2
P02557
Physiology
Del_3539746_3539908 – 162 bp deletion in exon3-4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001845
TUB2
P02557
Physiology
stop_gained_HIGH_c.549C>A_3539978 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001846
TUB2
P02557
Physiology
missense_variant_MODERATE_c.434C>T_3540145 – S145F N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001847
TUB2
P02557
Physiology
missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001848
TUB2
P02557
Physiology
Del_3540300_3540301 – 1bp deletion in coding exon 2 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Inversion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001849
TUB2
P02557
Physiology
Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Unknown
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001850
TUB2
P02557
Physiology
Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001851
TUB2
P02557
Physiology
Del_3540407_3540408 – 1bp deletion in coding exon 2 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001852
TUB2
P02557
Physiology
Del_3540970_3544000 – 3030bp deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001853
TUB2
P02557
Physiology
Del_3541317_3541856 – 539 bp deletion in first coding exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001854
TUB2
P02557
Physiology
splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001855
TUB2
P02557
Physiology
stop_gained_HIGH_c.153T>G_3541441 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001856
TUB2
P02557
Physiology
Del_3541499_3541502 – 3bp deletion in first coding exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001857
TUB2
P02557
Physiology
Ins_3541547_3541548 – 1 bp insertion in first coding exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben4)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Aspergillus nidulans
(species) D
Intraspecific
Candidate Gene
Jung MK; Wilder IB; Oakley BR (1992)
Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl r[...]
1 Additional References
GP00001787
TUB2
P02557
Physiology
Phe200Tyr
Aspergillus nidulans
(species)
Aspergillus nidulans
(species) D
beta-tubulin (ben4)
Aspergillus nidulans
(species)
Published - Accepted by Curator
BHLHE41
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Huerta-Sánchez E; Degiorgio M; Pagani L ; et al. (2013)
Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.
GP00000144
BHLHE41
Q9C0J9
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
BHLHE41
Homo sapiens
human - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001488
BMH1
P29311
Physiology
C>G p.Y216* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001489
BMH1
P29311
Physiology
G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001490
BMH1
P29311
Physiology
A>T p.K217* (2 times independently). Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001491
BMH1
P29311
Physiology
G>A p.D101N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001492
BMH1
P29311
Physiology
T>G p.L230* heterozygous. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001493
BMH1
P29311
Physiology
C>A p.N178K located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001494
BMH1
P29311
Physiology
G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001495
BMH1
P29311
Physiology
G>T p.G174V homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001496
BMH1
P29311
Physiology
G>A p.G174D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001497
BMH1
P29311
Physiology
A>G p.N178S homozygous functionally disruptive located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMH1
Growth rate (time to diauxic shift)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001498
BMH1
P29311
Physiology
G>A p.G55D located inside the groove where Bmh1p is expected to interact with other proteins as predicted by docking with arbitrary peptides and with two known Bmh1 protein partners (Serine/threonine-protein phosphatase PP1-2 and Heat shock protein Ssb1)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
BMH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BMP receptor IB (BMPRIB)
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Mulsant P; Lecerf F; Fabre S ; et al. (2001)
Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Bo[...]
GP00000146
BMPR-IB
Q9BDI4
Physiology
g.29382188A>G c.914A>G p.Q305R
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP receptor IB (BMPRIB)
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
N
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Galloway SM; McNatty KP; Cambridge LM ; et al. (2000)
Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]
GP00000147
Bmp15
Q9Z0L4
Physiology
c.67C>T p.Q23* N
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Galloway SM; McNatty KP; Cambridge LM ; et al. (2000)
Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]
GP00000148
Bmp15
Q9Z0L4
Physiology
A distinct single T>A transition occurs in FecXI carriers at nucleotide position 92 of the mature peptide . . . The mutation substitutes valine (V) with aspartic acid (D) at residue 31 (residue 299 of unprocessed protein) . . . The FecXI mutation is a non-conservative change in a highly conserved region of the protein
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Association Mapping
Demars J; Fabre S; Sarry J ; et al. (2013)
Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]
GP00000149
Bmp15
Q9Z0L4
Physiology
c.950C>T p.T317I
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Association Mapping
Demars J; Fabre S; Sarry J ; et al. (2013)
Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]
GP00000150
Bmp15
Q9Z0L4
Physiology
c.1009A>C p.N337H
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
N
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004)
Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]
GP00002155
Bmp15
Q9Z0L4
Physiology
c.718C>T ; p.Q239* N
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Galloway SM; McNatty KP; Cambridge LM ; et al. (2000)
Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and inferti[...]
GP00002156
Bmp15
Q9Z0L4
Physiology
c.G>A p.C321Y missense nonconservative substitution ; in vitro studies showed that the C53Y mutation was responsible for the impairment of the maturation process of the BMP15 protein resulting in a defective secretion of both the precursor and mature peptide
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004)
Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]
GP00002157
Bmp15
Q9Z0L4
Physiology
c.1100G>T p.S367I
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
Deletion
N
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Martinez-Royo A; Jurado JJ; Smulders JP ; et al. (2008)
A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in R[...]
1 Additional References
GP00002158
Bmp15
Q9Z0L4
Physiology
c.525_541del17 p.Pro45Asnfs*54 N
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Coding,
Insertion
N
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Lassoued N; Benkhlil Z; Woloszyn F ; et al. (2017)
FecX a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine [...]
GP00002159
Bmp15
Q9Z0L4
Physiology
C insertion (c.310insC) in the ovine BMP15 cDNA leading to a frame shift at protein position 101 N
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP15
Fertility (increased ovulation rate)
Cis-regulatory,
SNP
Ovis aries
sheep - (species) D
Domesticated
Association Mapping
Demars J; Fabre S; Sarry J ; et al. (2013)
Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyper[...]
GP00002329
Bmp15
Q9Z0L4
Physiology
T>A SPN upstream of the BMP15 gene associated with the prolificacy variability (P = 1.93E-11). Effect of +0.20 lamb per lambing at the heterozygous state.
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
BMP15
Ovis aries
sheep - (species)
Published - Accepted by Curator
BMP2
Fertility (egg production)
Bird head morphology (male comb)
Cis-regulatory,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Linkage Mapping
Johnsson M; Gustafson I; Rubin CJ ; et al. (2012)
A sexual ornament in chickens is affected by pleiotropic alleles at HAO1 and BMP2, selected during d[...]
1 Additional References
GP00000151
BMP2
Q90751
Physiology
Morphology
unknown; but intergenic QTL peak with decomposed effects on expression of BMP2 and HAO1
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
BMP2
Gallus gallus
chicken - (species)
Published - Accepted by Curator
BNA1
Nicotinid acid metabolism
Gene Loss,
Deletion
N
[Candida] glabrata
(species) D
Interspecific
Candidate Gene
Domergue R; Castaño I; De Las Peñas A ; et al. (2005)
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
GP00001878
BNA1
P47096
Physiology
Size of the deletion not mentioned in the paper N
Candida albicans
(species)
[Candida] glabrata
(species) D
BNA1
[Candida] glabrata
(species)
Published - Accepted by Curator
BNA2
Nicotinid acid metabolism
Gene Loss,
Deletion
N
[Candida] glabrata
(species) D
Interspecific
Candidate Gene
Domergue R; Castaño I; De Las Peñas A ; et al. (2005)
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
GP00001879
P47125NULL
Physiology
Size of the deletion not mentioned in the paper N
Candida albicans
(species)
[Candida] glabrata
(species) D
BNA2
[Candida] glabrata
(species)
Published - Accepted by Curator
BNA4
Nicotinid acid metabolism
Gene Loss,
Deletion
N
[Candida] glabrata
(species) D
Interspecific
Candidate Gene
Domergue R; Castaño I; De Las Peñas A ; et al. (2005)
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
GP00001880
BNA4
P38169
Physiology
Size of the deletion not mentioned in the paper N
Candida albicans
(species)
[Candida] glabrata
(species) D
BNA4
[Candida] glabrata
(species)
Published - Accepted by Curator
BNA5
Nicotinid acid metabolism
Gene Loss,
Deletion
N
[Candida] glabrata
(species) D
Interspecific
Candidate Gene
Domergue R; Castaño I; De Las Peñas A ; et al. (2005)
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
GP00001881
BNA5
Q05979
Physiology
Size of the deletion not mentioned in the paper N
Candida albicans
(species)
[Candida] glabrata
(species) D
BNA5
[Candida] glabrata
(species)
Published - Accepted by Curator
BNA6
Nicotinid acid metabolism
Gene Loss,
Deletion
N
[Candida] glabrata
(species) D
Interspecific
Candidate Gene
Domergue R; Castaño I; De Las Peñas A ; et al. (2005)
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
GP00001882
BNA6
P43619
Physiology
Size of the deletion not mentioned in the paper N
Candida albicans
(species)
[Candida] glabrata
(species) D
BNA6
[Candida] glabrata
(species)
Published - Accepted by Curator
BOLTING TIME CONTROL 1 (BvBTC1)
Flowering time
Cis-regulatory,
Unknown
Beta vulgaris
(species)
Domesticated
Linkage Mapping
Pin PA; Zhang W; Vogt SH ; et al. (2012)
The role of a pseudo-response regulator gene in life cycle adaptation and domestication of beet.
GP00000155
BTC1
I3NN18
Physiology
unknown
Beta vulgaris
(species)
Beta vulgaris
(species)
BOLTING TIME CONTROL 1 (BvBTC1)
Beta vulgaris
(species)
Published - Accepted by Curator
Brevis radix (BRX)
pH tolerance (acidic soil)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Gujas B; Alonso-Blanco C; Hardtke CS (2012)
Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil.
GP00001236
BRX
Q17TI5
Physiology
K188* (stop codon) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Brevis radix (BRX)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
brittle endosperm2 (Bt2) = endosperm ADP-glucose pyrophosphorylase small subunit
Sweet and brittle seed
Unknown,
Unknown
Zea mays
(species)
Domesticated
Linkage Mapping
Preiss J; Danner S; Summers PS ; et al. (1990)
Molecular Characterization of the Brittle-2 Gene Effect on Maize Endosperm ADPglucose Pyrophosphoryl[...]
GP00000158
bt2
Q84J79
Physiology
Not identified
Zea mays
(species)
Zea mays
(species)
brittle endosperm2 (Bt2) = endosperm ADP-glucose pyrophosphorylase small subunit
Zea mays
(species)
Published - Accepted by Curator
Brix9-2-5/LIN5 invertase
Fruit sugar content
Unknown,
Unknown
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Fridman E; Carrari F; Liu YS ; et al. (2004)
Zooming in on a quantitative trait for tomato yield using interspecific introgressions.
GP00000159
LIN5
P93199
Physiology
Not identified
Solanum pennellii
(species)
Solanum lycopersicum
tomato - (species) D
Brix9-2-5/LIN5 invertase
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
BTN1A1
Pathogen resistance (virus)
Coding,
SNP
N
Gallus gallus
chicken - (species)
Domesticated
Linkage Mapping
Elleder D; Stepanets V; Melder DC ; et al. (2005)
The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian but[...]
GP00002160
BTN1A1
Q13410
Physiology
g.808011C>A c.165C>A p.C55* N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
BTN1A1
Gallus gallus
chicken - (species)
Published - Accepted by Curator
btr1
Seed shattering (grain dispersal ; retention)
Coding,
Deletion
N
Hordeum vulgare subsp. vulgare
domesticated barley - (subspecies) D
Domesticated
Linkage Mapping
Pourkheirandish M; Hensel G; Kilian B ; et al. (2015)
Evolution of the Grain Dispersal System in Barley.
GP00001445
BTR1
A0A0K1RJT0
Physiology
1bp deletion at position 202 inducing a frameshift N
Hordeum vulgare
(species)
Hordeum vulgare subsp. vulgare
domesticated barley - (subspecies) D
btr1
Hordeum vulgare subsp. vulgare
domesticated barley - (subspecies)
Published - Accepted by Curator
btr2
Seed shattering (grain dispersal ; retention)
Coding,
Deletion
N
Hordeum vulgare subsp. vulgare
domesticated barley - (subspecies) D
Domesticated
Linkage Mapping
Pourkheirandish M; Hensel G; Kilian B ; et al. (2015)
Evolution of the Grain Dispersal System in Barley.
GP00001446
BTR2
A0A0K1RKV9
Physiology
11bp deletion at position 254-264 creating a frameshift N
Hordeum vulgare
(species)
Hordeum vulgare subsp. vulgare
domesticated barley - (subspecies) D
btr2
Hordeum vulgare subsp. vulgare
domesticated barley - (subspecies)
Published - Accepted by Curator
BUL2
Telomere length
Aging
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Kwan EX; Foss E; Kruglyak L ; et al. (2011)
Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and tel[...]
GP00000166
BUL2
Q03758
Physiology
Physiology
Leu883Phe
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
BUL2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
BvCPSF73-Ia
Bolting time
Coding,
Deletion
N
Beta vulgaris
(species) D
Intraspecific
Linkage Mapping
Tränkner C; Lemnian IM; Emrani N ; et al. (2016)
A Detailed Analysis of the BR Locus Suggests a New Mechanism for Bolting after Winter in Sugar Beet [...]
GP00001411
CPSF73-I
Q9C952
Physiology
2bp deletion causing a frameshift resulting in a two third truncated protein N
Beta vulgaris
(species)
Beta vulgaris
(species) D
BvCPSF73-Ia
Beta vulgaris
(species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac)
Coding,
Unknown
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Xu X; Yu L; Wu Y (2005)
Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]
GP00000160
BtR
Q19KJ3
Physiology
premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
cadherin
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Insertion
N
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Gahan LJ; Gould F; Heckel DG (2001)
Identification of a gene associated with Bt resistance in Heliothis virescens.
GP00000161
BtR
Q19KJ3
Physiology
Insertion of retrotransposon N
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
cadherin
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00000162
BtR
Q19KJ3
Physiology
126bp in-frame deletion N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00000163
BtR
Q19KJ3
Physiology
202bp deletion N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Deletion
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00000164
BtR
Q19KJ3
Physiology
24bp in-frame deletion
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
SNP
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Zhang H; Tian W; Zhao J ; et al. (2012)
Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.
GP00000165
BtR
Q19KJ3
Physiology
E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac)
Coding,
SNP
N
Helicoverpa punctigera
(species) D
Intraspecific
Candidate Gene
Walsh T; James B; Chakroun M ; et al. (2018)
Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]
GP00002055
BtR
Q19KJ3
Physiology
splice site GT mutated in GA so that splicing does not occur correctly and a 58 bp insertion is found in the cDNA sequence of the cadherin gene. This insertion disrupts the coding sequence in cadherin domain 9 causing a downstream frameshift and a premature stop codon for the rest of the protein. This would result in a truncated protein of 1243 amino acids without the putative binding domain; the membrane anchoring domain; presumably retained inside the cell and not exposed to the Cry1Ac; or alternatively; exported into the gut where it would be degraded N
Helicoverpa punctigera
(species)
Helicoverpa punctigera
(species) D
cadherin
Helicoverpa punctigera
(species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Pectinophora gossypiella
pink bollworm - (species) D
Experimental Evolution
Candidate Gene
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00002449
A0A1B0RHM4
Physiology
insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon designated CR1-1_Pg. Unlike most other CR1 elements CR1-1_Pg is intact and transcribed by a flanking promoter. It contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function. N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Deletion
N
Pectinophora gossypiella
pink bollworm - (species) D
Experimental Evolution
Candidate Gene
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
GP00002450
A0A1B0RHM4
Physiology
24-bp deletion in putative exon 21 causing the loss of eight amino acid residues N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Deletion
N
Pectinophora gossypiella
pink bollworm - (species) D
Experimental Evolution
Candidate Gene
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
GP00002451
A0A1B0RHM4
Physiology
126-bp deletion spanning a putative intron 15/exon 16 splice site that introduces a premature stop codon and causes loss of the final 929 amino acid residues. N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Deletion
Ostrinia furnacalis
Asian corn borer - (species) D
Intraspecific
Candidate Gene
Jin T; Chang X; Gatehouse AM ; et al. (2014)
Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...]
1 Additional References
GP00002464
A0A1B0RHM4
Physiology
MPR-r2 has a 26-amino acid residue deletion in the TBR which results in reduced binding of Cry1Ac compared to the MPR from the susceptible strain.
Ostrinia furnacalis
Asian corn borer - (species)
Ostrinia furnacalis
Asian corn borer - (species) D
cadherin
Ostrinia furnacalis
Asian corn borer - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
SNP
Ostrinia furnacalis
Asian corn borer - (species) D
Intraspecific
Candidate Gene
Jin T; Chang X; Gatehouse AM ; et al. (2014)
Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...]
1 Additional References
GP00002465
A0A1B0RHM4
Physiology
Thr1457Ser
Ostrinia furnacalis
Asian corn borer - (species)
Ostrinia furnacalis
Asian corn borer - (species) D
cadherin
Ostrinia furnacalis
Asian corn borer - (species)
Published - Accepted by Curator
calmodulin binding hydrolase
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001438
Q9FHQ0
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
calmodulin binding hydrolase
Arabidopsis arenosa
(species)
Published - Accepted by Curator
Casparian strip membrane domain protein 1
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001432
CASP1
Q9SIH4
Physiology
five aa sustitutions
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
Casparian strip membrane domain protein 1
Arabidopsis arenosa
(species)
Published - Accepted by Curator
CAST
Meat tenderness
Cis-regulatory,
Unknown
Sus scrofa domesticus
domestic pig - (subspecies)
Domesticated
Linkage Mapping
Nonneman D; Lindholm-Perry AK; Shackelford SD ; et al. (2011)
Predictive markers in calpastatin for tenderness in commercial pig populations.
GP00000170
CAST
P20810
Physiology
4 candidate SNPs in putative enhancers with nuclear factor-binding properties
Sus scrofa
pig - (species)
Sus scrofa domesticus
domestic pig - (subspecies)
CAST
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
Catecholamines up
Bristle number
Lifespan
Locomotor activity
Sleep
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Carbone MA; Jordan KW; Lyman RF ; et al. (2006)
Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Droso[...]
1 Additional References
GP00000172
Catsup
Q9V3A4
Morphology
Physiology
Behavior
Behavior
unknown; but most large-effect variants appear to be coding
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Catecholamines up
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
cathepsin E
Digestion (absence of stomach)
2 Mutations:
Coding
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001910
CTSE
P14091
Physiology
2 mutations
Monodelphis domestica
gray short-tailed opossum - (species)
Homo sapiens
human - (species)
Ornithorhynchus anatinus
platypus - (species) D
cathepsin E
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
CBF gene cluster
Temperature tolerance (cold)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Gery C; Zuther E; Schulz E ; et al. (2011)
Natural variation in the freezing tolerance of Arabidopsis thaliana: effects of RNAi-induced CBF dep[...]
GP00000174
B1NSN2
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CBF gene cluster
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CBF12
Temperature tolerance (cold)
Coding,
Unknown
Triticum monococcum
(species)
Domesticated
Linkage Mapping
Knox AK; Li C; Vágújfalvi A ; et al. (2008)
Identification of candidate CBF genes for the frost tolerance locus Fr-Am2 in Triticum monococcum.
GP00000175
B1NSN2
Physiology
possibly 5a.a. deletion in DNA binding domain
Triticum monococcum
(species)
Triticum monococcum
(species)
CBF12
Triticum monococcum
(species)
Published - Accepted by Curator
CBF2-CBF4; CBF13
Temperature tolerance (cold)
Gene Amplification,
Complex Change
Hordeum vulgare
(species)
Domesticated
Candidate Gene
Knox AK; Dhillon T; Cheng H ; et al. (2010)
CBF gene copy number variation at Frost Resistance-2 is associated with levels of freezing tolerance[...]
GP00000176
B1NSN2
Physiology
tandem duplication of CBF2-CBF4 region and/or pseudogenisation of CBF13
Hordeum vulgare
(species)
Hordeum vulgare
(species)
CBF2-CBF4; CBF13
Hordeum vulgare
(species)
Published - Accepted by Curator
CCAAT-enhancer-binding protein alpha (CEBPA)
Hematopoiesis (blood basophil count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001603
CEBPA
P49715
Physiology
C>T at the associated SNP which resides 39kb dowstream from CEBPA near a separate enhancer that influences CEBPA expression along various myeloid lineages. T allele was associated with a 28.6% reduction in enhancer activity.
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CCAAT-enhancer-binding protein alpha (CEBPA)
Homo sapiens
human - (species)
Published - Accepted by Curator
CCL3L1
Pathogen resistance (HIV)
Gene Amplification,
Indel
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Gonzalez E; Kulkarni H; Bolivar H ; et al. (2005)
The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
GP00000177
CCL3L1
P16619
Physiology
Copy number Variant
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
CCL3L1
Homo sapiens
human - (species)
Published - Accepted by Curator
CENTRORADIALIS (HvCEN)
Flowering time
Seasonal growth
Coding,
SNP
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Comadran J; Kilian B; Russell J ; et al. (2012)
Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and [...]
GP00000179
CEN
Q9ZNV5
Physiology
Physiology
P135A
Hordeum vulgare
(species)
Hordeum vulgare
(species)
CENTRORADIALIS (HvCEN)
Hordeum vulgare
(species)
Published - Accepted by Curator
CEP55
Recombination rate (female)
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001667
CEP55
E1B8M0
Physiology
Associated SNP located near the gene
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
CEP55
Bos taurus
cattle - (species)
Published - Accepted by Curator
Cf-2.1 and Cf-2.2
Pathogen resistance (leaf mold fungus ; root parasitic nematode)
Gene Loss,
Deletion
N
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Dixon MS; Jones DA; Keddie JS ; et al. (1996)
The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat[...]
2 Additional References
GP00000180
Q41398
Physiology
loss of the two genes Cf-2.1 and Cf-2.2 (see Dixon et al. 1998) in cultivated tomato - resistance re-acquired from related species N
Solanum pimpinellifolium
(species)
Solanum lycopersicum
tomato - (species) D
Cf-2.1 and Cf-2.2
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
Cf-4/9
Pathogen resistance
Gene Loss,
Complex Change
Solanum lycopersicum
tomato - (species)
Domesticated
Linkage Mapping
Parniske M; Hammond-Kosack KE; Golstein C ; et al. (1997)
Novel disease resistance specificities result from sequence exchange between tandemly repeated genes[...]
GP00000181
Cf-4A
Q7DLS4
Physiology
partial loss of two gene coding regions located in tandem; resulting in a chimeric gene
Solanum pimpinellifolium
(species)
Solanum lycopersicum
tomato - (species)
Cf-4/9
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
CG11699
Xenobiotic resistance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Mateo L; Ullastres A; González J (2014)
A transposable element insertion confers xenobiotic resistance in Drosophila.
GP00001399
Dmel\CG11699
Q9VYX5
Physiology
insertion of a 186bp POGON1 element in the 3'UTR
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
CG11699
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CG8492
Pathogen resistance (Drosophila C virus & flock house virus)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Experimental Evolution
Association Mapping
Martins NE; Faria VG; Nolte V ; et al. (2014)
Host adaptation to viruses relies on few genes with different cross-resistance properties.
GP00001481
Dmel\CG8492
Q9VSA5
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
CG8492
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Chalk5
Grain chalkiness
Amylose content
Grain yield
Cis-regulatory,
SNP
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Li Y; Fan C; Xing Y ; et al. (2014)
Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase influencing grain chalkiness in rice.
GP00001309
Chalk5
A2Y0L3
Morphology
Physiology
Physiology
Two candidate SNPs at positions -721 and - 485 in promoter region
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Chalk5
Oryza sativa
rice - (species)
Published - Accepted by Curator
Chit beta-GlcNAcase
Silk fineness
Cis-regulatory,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Tong X; Han MJ; Lu K ; et al. (2022)
High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]
GP00002401
P49010
Physiology
BmChit β-GlcNAcase gene is expressed at a significantly higher level in fine silk strains (Suxiu, Chunfeng) compared to coarse silk strains. CRISPR-cas9 mediated knockout of the BmChit β-GlcNAcase gene produced coarser silk.
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
Chit beta-GlcNAcase
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide ; benzoylurea)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Douris V; Steinbach D; Panteleri R ; et al. (2016)
Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]
GP00001600
CHS1
A3KCN0
Physiology
T>G p.I1042M (I1056 in D. melanogaster) located in the C-terminal transmembrane domain
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
Chitin synthase 1 (CHS1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide; benzoylurea)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Douris V; Steinbach D; Panteleri R ; et al. (2016)
Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]
GP00001601
CHS1
A3KCN0
Physiology
A>T p.I1042F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
Chitin synthase 1 (CHS1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide; etoxazole acaricide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species)
Intraspecific
Linkage Mapping
Demaeght P; Osborne EJ; Odman-Naresh J ; et al. (2014)
High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally di[...]
1 Additional References
GP00001602
chs1
H9U0G2
Physiology
A>T p.I1017F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species)
Chitin synthase 1 (CHS1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide; benzoylurea)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Suzuki Y; Shiotsuki T; Jouraku A ; et al. (2017)
Benzoylurea resistance in western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae)[...]
GP00002628
CHS1
A3KCN0
Physiology
isoleucine to methionine
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
Chitin synthase 1 (CHS1)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
CHKov1
Pathogen resistance
Xenobiotic resistance (insecticide)
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Magwire MM; Bayer F; Webster CL ; et al. (2011)
Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...]
1 Additional References
GP00000182
CHKov1
Q961V7
Physiology
Physiology
Insertion of a Doc TE element resulting in novel; seemingly functional short protein
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
CHKov1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
chloroquine resistance transporter
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001533
CRT
Q9N623
Physiology
p.Ile356Thr
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
chloroquine resistance transporter
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
2 Mutations:
Coding
SNP
Erinaceus concolor
southern white-breasted hedgehog - (species) D
Erinaceus europaeus
western European hedgehog - (species) D
Intergeneric or Higher
Candidate Gene
Drabeck DH; Dean AM; Jansa SA (2015)
Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]
GP00000183
CHRNA1
P02708
Physiology
2 mutations
Carnivora
carnivores - (order)
Erinaceus concolor
southern white-breasted hedgehog - (species) D
Erinaceus europaeus
western European hedgehog - (species) D
CHRNA1
Erinaceus concolor
southern white-breasted hedgehog - (species)
Erinaceus europaeus
western European hedgehog - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
2 Mutations:
Coding
SNP
Mellivora capensis
ratel - (species) D
Intergeneric or Higher
Candidate Gene
Drabeck DH; Dean AM; Jansa SA (2015)
Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]
GP00000184
CHRNA1
P02708
Physiology
2 mutations
Carnivora
carnivores - (order)
Mellivora capensis
ratel - (species) D
CHRNA1
Mellivora capensis
ratel - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
4 Mutations:
Coding
SNP
Herpestes ichneumon
Egyptian mongoose - (species) D
Intergeneric or Higher
Candidate Gene
Barchan D; Kachalsky S; Neumann D ; et al. (1992)
How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.
2 Additional References
GP00001686
CHRNA1
P02708
Physiology
4 mutations
Carnivora
carnivores - (order)
Herpestes ichneumon
Egyptian mongoose - (species) D
CHRNA1
Herpestes ichneumon
Egyptian mongoose - (species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
Coding,
SNP
Naja haje
(species) D
Intergeneric or Higher
Candidate Gene
Takacs Z; Wilhelmsen KC; Sorota S (2004)
Cobra ( Naja spp. ) nicotinic acetylcholine receptor exhibits resistance to Erabu sea snake ( Latica[...]
GP00001720
CHRNA1
P02708
Physiology
Phe189Asn - The inhibitory effect on the pharmacological action of the toxin is primarily attributed to the presence of glycosylation at position N189.
Carnivora
carnivores - (order)
Naja haje
(species) D
CHRNA1
Naja haje
(species)
Published - Accepted by Curator
CHRNA1
Xenobiotic resistance (snake venom)
2 Mutations:
Coding
SNP
Sus scrofa
pig - (species) D
Intergeneric or Higher
Candidate Gene
Drabeck DH; Dean AM; Jansa SA (2015)
Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine rece[...]
GP00001721
CHRNA1
P02708
Physiology
2 mutations
Carnivora
carnivores - (order)
Sus scrofa
pig - (species) D
CHRNA1
Sus scrofa
pig - (species)
Published - Accepted by Curator
CHRNA3/5 nicotine receptor cluster
Aging
Smoking behavior
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Joshi PK; Fischer K; Schraut KE ; et al. (2016)
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
GP00000185
CHRNA3
P32297
Physiology
Physiology
unknown; complex variation with SNP association signal
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CHRNA3/5 nicotine receptor cluster
Homo sapiens
human - (species)
Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)
Fragrance
3 Mutations:
N
Petunia exserta
(species) D
Interspecific
Linkage Mapping
Amrad A; Moser M; Mandel T ; et al. (2016)
Gain and Loss of Floral Scent Production through Changes in Structural Genes during Pollinator-Media[...]
GP00001391
CNL
A0A172W603
Physiology
3 mutations
Petunia axillaris
(species)
Petunia exserta
(species) D
Cinnamate-CoA ligase 1 (CNL1)
Petunia exserta
(species)
Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)
Fragrance
Coding,
SNP
N
Capsella rubella
(species) D
Interspecific
Linkage Mapping
Sas C; Müller F; Kappel C ; et al. (2016)
Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]
GP00001767
CNL
A0A172W603
Physiology
serine-to-arginine exchange at position 453 (T-to-A nucleotide exchange at genomic position 7 539 424) - this mutation is located immediately next to highly conserved amino acids predicted to be involved in adenosine monophosphate and coenzyme A binding; it involves two biochemically very dissimilar amino acids; and the serine at this position is conserved N
Capsella grandiflora
(species)
Capsella rubella
(species) D
Cinnamate-CoA ligase 1 (CNL1)
Capsella rubella
(species)
Published - Accepted by Curator
Cinnamate-CoA ligase 1 (CNL1)
Fragrance
Coding,
Deletion
N
Capsella rubella
(species) D
Interspecific
Linkage Mapping
Sas C; Müller F; Kappel C ; et al. (2016)
Repeated Inactivation of the First Committed Enzyme Underlies the Loss of Benzaldehyde Emission afte[...]
GP00001768
CNL
A0A172W603
Physiology
a 4 bp deletion resulting in a frameshift 795 bp downstream of the start codon and causing a premature stop codon N
Capsella grandiflora
(species)
Capsella rubella
(species) D
Cinnamate-CoA ligase 1 (CNL1)
Capsella rubella
(species)
Published - Accepted by Curator
CINNAMOYL CO-A REDUCTASE 1
Fiber content
Coding,
Unknown
N
Brassica napus
rape - (species)
Domesticated
Linkage Mapping
Liu L; Stein A; Wittkop B ; et al. (2012)
A knockout mutation in the lignin biosynthesis gene CCR1 explains a major QTL for acid detergent lig[...]
GP00000186
CCR1
Q9S9N9
Physiology
Frameshift mutation in exon1 N
Brassica napus
rape - (species)
Brassica napus
rape - (species)
CINNAMOYL CO-A REDUCTASE 1
Brassica napus
rape - (species)
Published - Accepted by Curator
CIS1
Xenobiotic resistance (citrinin)
Cis-regulatory,
Unknown
Saccharomyces paradoxus
(species) D
Domesticated
Association Mapping
Naranjo S; Smith JD; Artieri CG ; et al. (2015)
Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.
GP00001313
ATG31
Q12421
Physiology
mutations within 1kb in promotor region
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces paradoxus
(species) D
CIS1
Saccharomyces paradoxus
(species)
Published - Accepted by Curator
CLH1
Xenobiotic resistance (fungicide: guazatine)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Atanasov KE; Barboza-Barquero L; Tiburcio AF ; et al. (2016)
Genome Wide Association Mapping for the Tolerance to the Polyamine Oxidase Inhibitor Guazatine in Ar[...]
GP00001234
CLH1
O22527
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CLH1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Clock
Circadian rhythm
Unknown,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xiang H; Liu X; Li M ; et al. (2018)
The evolutionary road from wild moth to domestic silkworm.
1 Additional References
GP00002409
Clk
O61735
Physiology
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
Clock
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
CmACS-7
Flower sex determination (male organs)
Coding,
SNP
Cucumis melo
muskmelon - (species)
Domesticated
Linkage Mapping
Boualem A; Fergany M; Fernandez R ; et al. (2008)
A conserved mutation in an ethylene biosynthesis enzyme leads to andromonoecy in melons.
GP00000187
ACS7
Q9STR4
Physiology
A57V
Cucumis melo
muskmelon - (species)
Cucumis melo
muskmelon - (species)
CmACS-7
Cucumis melo
muskmelon - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
1 Additional References
GP00002163
Cmah
Q61419
Physiology
c.179G>T p.G60V
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
1 Additional References
GP00002164
Cmah
Q61419
Physiology
c.364C>T p.P122S
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
Deletion
N
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002165
Cmah
Q61419
Physiology
c.1322delT p.Leu441* N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002166
Cmah
Q61419
Physiology
c.139G>A p.V47M
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002167
Cmah
Q61419
Physiology
c.268T>A p.Y89N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002168
Cmah
Q61419
Physiology
c.1600G>A p.D534N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CmWIP1
Flower sex determination (female vs. hermaphrodite)
Cis-regulatory,
Insertion
Cucumis melo
muskmelon - (species) D
Domesticated
Linkage Mapping
Martin A; Troadec C; Boualem A ; et al. (2009)
A transposon-induced epigenetic change leads to sex determination in melon.
GP00000188
WIP1
Q8GXA4
Physiology
Promoter insertion of a Transcription Factor Binding Site allowing propagation of heritable methylation
Cucumis melo
muskmelon - (species)
Cucumis melo
muskmelon - (species) D
CmWIP1
Cucumis melo
muskmelon - (species)
Published - Accepted by Curator
CNL9 (=Sr35)
Pathogen resistance
Coding,
Complex Change
Triticum monococcum
(species)
Domesticated
Linkage Mapping
Saintenac C; Zhang W; Salcedo A ; et al. (2013)
Identification of wheat gene Sr35 that confers resistance to Ug99 stem rust race group.
GP00000189
Sr35
S5ABD6
Physiology
Coding variation in the LRR domain - a spontaneous gene conversion between CNL4 and CNL9 is the most parsimonious explanation for the three linked mutations in CNL9
Triticum monococcum
(species)
Triticum monococcum
(species)
CNL9 (=Sr35)
Triticum monococcum
(species)
Published - Accepted by Curator
Couch potato
Diapause
Coding,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Schmidt PS; Zhu CT; Das J ; et al. (2008)
An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]
GP00000191
cpo
Q01617
Physiology
Ile462Lys
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Couch potato
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
COX18
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00001708
COX18
P53239
Physiology
Leu59His (T>A at position 617107 according to Table 1) - CTY to CAY position 617107
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
COX18
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
CPLX1
Recombination rate
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001659
CPLX1
Q0IIL7
Physiology
On chromosome 6. Associated SNP in the intron of the gene
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
CPLX1
Bos taurus
cattle - (species)
Published - Accepted by Curator
Cpm1
Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)
Coding,
SNP
N
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Darboux I; Charles JF; Pauchet Y ; et al. (2007)
Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]
GP00002102
Q95WY5
Physiology
Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin. N
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Cpm1
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Cpm1
Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)
Coding,
Insertion
N
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Darboux I; Charles JF; Pauchet Y ; et al. (2007)
Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]
GP00002103
Q95WY5
Physiology
Insertion of a 451-bpTE into the exon 2 of the toxin receptor gene. The insertion induces a new mRNA splicing event that creates a shorter transcript. This new transcript encodes an altered receptor unable to interact with the toxin resulting in resistance to this insecticide. The missing portion includes GPI-anchoring signals N
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Cpm1
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Cpm1
Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)
Coding,
Deletion
N
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Guo QY; Cai QX; Yan JP ; et al. (2013)
Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaeri[...]
1 Additional References
GP00002552
Q95WY5
Physiology
one-nucleotide deletion which results in a premature stop codon and leads to production of a truncated protein. N
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
Cpm1
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
CPR
Xenobiotic resistance
Gene Amplification,
Insertion
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Linkage Mapping
Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021)
High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]
GP00002398
Cpr
Q27597
Physiology
Pyflubumide resistant populations are estimated to harbor three CPR copies by two methods, whereas susceptible populations have a single CPR copy.
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
CPR
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Cryptochrome 2 (CRY2)
Circadian rhythm
Unknown,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xiang H; Liu X; Li M ; et al. (2018)
The evolutionary road from wild moth to domestic silkworm.
1 Additional References
GP00002408
cry
O77059
Physiology
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
Cryptochrome 2 (CRY2)
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele
Flowering time
Fruit shape (fruit length)
Flower morphology (ovule number per fruit)
Fertility (percentage of unfertilized ovules)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001)
A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2.
3 Additional References
GP00000192
CRY2
Q96524
Physiology
Morphology
Morphology
Physiology
V367M
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Cryptochrome 2 (CRY2) EDI allele
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CS
Plant secondary metabolite (pungency)
Cis-regulatory,
Deletion
N
Capsicum annuum
(species) D
Domesticated
Candidate Gene
Kim S; Park M; Yeom SI ; et al. (2014)
Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]
1 Additional References
GP00001447
csy1
Q09UW1
Physiology
Large 2.5 kb deletion spanning 1.8 kb of the putative promoter and 0.7 kb of the first exon was observed in the C. annuum Bellpeppers N
Capsicum frutescens
(species)
Capsicum annuum
(species) D
CS
Capsicum annuum
(species)
Published - Accepted by Curator
CXCL16
Pathogen resistance (lymphocyte susceptibility to virus)
Coding,
SNP
Equus caballus
horse - (species)
Intraspecific
Association Mapping
Sarkar S; Bailey E; Go YY ; et al. (2016)
Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus In[...]
GP00001591
CXCL16
F7CTX0
Physiology
4 candidate nonsynonymous substitutions within exon 1(in 2 susceptible variants): (1)c.715A>T p.Tyr40Phe (2)c.801G>C w.Asp49His (3)c.804T>A/G p.Phe50Ile (4)c.810G>A p.Glu52Lys
Equus caballus
horse - (species)
Equus caballus
horse - (species)
CXCL16
Equus caballus
horse - (species)
Published - Accepted by Curator
CYC8
Salt tolerance (experimental evolution)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Anderson JB; Funt J; Thompson DA ; et al. (2010)
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...]
1 Additional References
GP00000195
CYC8
P14922
Physiology
1bp substitution resulting in premature stop codon N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
CYC8
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
CYCD5;1
Endoreduplication
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sterken R; Kiekens R; Boruc J ; et al. (2012)
Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoredupl[...]
GP00000196
CYCD5-1
Q2V3B2
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CYCD5;1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Cyp12d1
Xenobiotic resistance (caffeine tolerance)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Najarro MA; Hackett JL; Smith BR ; et al. (2015)
Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.
GP00000198
Cyp12d1-d
Q7KR10
Physiology
Copy number Variant
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Cyp12d1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CYP1A2
Enzymatic activity
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Murayama N; Soyama A; Saito Y ; et al. (2004)
Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]
GP00000199
CYP1A2
P05177
Physiology
F186L
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
CYP1A2
Homo sapiens
human - (species)
Published - Accepted by Curator
Cyp28d1
Xenobiotic resistance (nicotine ; larval stage)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Chakraborty M; VanKuren NW; Zhao R ; et al. (2018)
Hidden genetic variation shapes the structure of functional elements in Drosophila.
2 Additional References
GP00001407
Cyp28d1
Q9VMT5
Physiology
insertion of a partial 1.5kb Accord transposable element and a Cyp28d1 gene tandem duplication (CNV - 3754 bp) that may play complementary role in resistance levels
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cyp28d1
Xenobiotic resistance (nicotine ; larval stage)
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002113
Cyp28d1
Q9VMT5
Physiology
insertion of a FW element (4720 bp) into the coding region (exon) of the second copy of the Cyp28d1 (there is still another copy of the gene left due to a duplication). Associated with a decrease in Cyp28d2 gene expression and a decrease in nicotin resistance.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cyp28d1-Cyp28d2
Xenobiotic resistance (nicotine ; larval stage)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002112
Cyp28d1
Q9VMT5
Physiology
duplication of 6063 bp which includes genes Cyp28d1; Cyp28d2 and CG7742. Associated with increased expression of Cyp28d2 and increased resistance to nicotin
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1-Cyp28d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cyp28d1-Cyp28d2
Xenobiotic resistance (nicotine ; larval stage)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002114
Cyp28d1
Q9VMT5
Physiology
duplication of a 15297-bp region; which encompasses 5 genes: Msp300 Cyp28d2 Cyp28d1 CG7742 and CG14034. Associated with increased expression of Cyp28d1 gene expression and increased nicotin resistance
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1-Cyp28d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CYP2C9
Xenobiotic resistance (anti-coagulant drug response)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009)
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...]
1 Additional References
GP00000200
CYP2C9
P11712
Physiology
I359L
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CYP2C9
Homo sapiens
human - (species)
Published - Accepted by Curator
CYP321A8
Xenobiotic resistance (organophosphate; chlorpyrifos; pyrethroid; cypermethrin; deltamethrin)
Cis-regulatory,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Candidate Gene
Hu B; Huang H; Hu S ; et al. (2021)
Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron [...]
GP00002394
CYP321A8
A0A286QUG5
Physiology
A > G at position -197bp in a cis-regulatory region, leading to increased expression of the gene
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
CYP321A8
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Association Mapping
Joußen N; Agnolet S; Lorenz S ; et al. (2012)
Resistance of Australian Helicoverpa armigera to fenvalerate is due to the chimeric P450 enzyme CYP3[...]
1 Additional References
GP00002477
CYP337B3
A0A0H3V333
Physiology
The unique P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The exclusive presence of CYP337B3 in resistant insects of this strain confers a 42-fold resistance to fenvalerate.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Rasool Akhtar; Joußen Nicole; Lorenz Sybille ; et al. (2014
)
An independent occurrence of the chimeric P450 enzyme CYP337B3 of Helicoverpa armigera confers cyper[...]
1 Additional References
GP00002478
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The Pakistani and the Australian CYP337B3 alleles differ by 18 synonymous and three nonsynonymous SNPs and additionally in the length and sequence of the intron.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015
)
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...]
1 Additional References
GP00002479
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015
)
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...]
1 Additional References
GP00002480
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015
)
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...]
1 Additional References
GP00002481
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
GP00002482
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
GP00002483
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
GP00002484
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Insertion
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
1 Additional References
GP00002485
CYP337B3
A0A0H3V333
Physiology
Introgression of the CYP337B3v2 resistant allele from Helicoverpa armigera
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
CYP337B3
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
CYP392A16
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002471
Ace
P07140
Physiology
several non-synonymous SNP - exact causing amino acid change(s) unknown. Functional analysis of the putative promoter region from the resistant and susceptible parental strains revealed a higher reporter gene expression confirming the presence of cis-acting regulatory mechanisms.
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
CYP392A16
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
CYP392E8
Xenobiotic resistance
Cis-regulatory,
Unknown
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Linkage Mapping
Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021)
High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]
GP00002397
Physiology
increase in transcription of CYP392E8.
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
CYP392E8
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
CYP4F2
Xenobiotic resistance (anti-coagulant drug response)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009)
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...]
1 Additional References
GP00000203
CYP4F2
P78329
Physiology
V433M
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CYP4F2
Homo sapiens
human - (species)
Published - Accepted by Curator
CYP6AB3
Xenobiotic resistance (imperatorin)
Coding,
SNP
Depressaria pastinacella
(species)
Intraspecific
Candidate Gene
Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007)
Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]
GP00000204
CYP6AB3
Q7YZS3
Physiology
Ala92Val (and potentiallly 4 other a.a. substitutions)
Depressaria pastinacella
(species)
Depressaria pastinacella
(species)
CYP6AB3
Depressaria pastinacella
(species)
Published - Accepted by Curator
CYP6AY1
Xenobiotic resistance (imidacloprid; buprofezin)
Cis-regulatory,
Unknown
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Pang R; Li Y; Dong Y ; et al. (2014)
Identification of promoter polymorphisms in the cytochrome P450 CYP6AY1 linked with insecticide resi[...]
GP00002399
CYP6AY1
A0A1L1VFS3
Physiology
CYP6AY1 is expressed at a higher level in a field-collected BPH strain that is highly resistant to both imidacloprid and buprofezin. Polymorphism in the promoter region associated with various levels of resistance.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6AY1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6B1
Xenobiotic resistance
Host plant specialization
Coding,
SNP
Papilio polyxenes
black swallowtail - (species)
Interspecific
Candidate Gene
Li W; Schuler MA; Berenbaum MR (2003)
Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Sp[...]
GP00000205
CYP6B1
Q04552
Physiology
Physiology
Ile484Phe and probably other a.a. substitutions
Nymphalidae
brushfoots - (family)
Papilio polyxenes
black swallowtail - (species)
CYP6B1
Papilio polyxenes
black swallowtail - (species)
Published - Accepted by Curator
CYP6B4
Xenobiotic resistance
Host plant specialization
Coding,
SNP
Papilio glaucus
eastern tiger swallowtail - (species)
Intergeneric or Higher
Candidate Gene
Mao W; Schuler MA; Berenbaum MR (2007)
Cytochrome P450s in Papilio multicaudatus and the transition from oligophagy to polyphagy in the Pap[...]
GP00000206
CYP6B4
Q27902
Physiology
Physiology
Lys484Ser and probably other a.a. substitutions
Nymphalidae
brushfoots - (family)
Papilio glaucus
eastern tiger swallowtail - (species)
CYP6B4
Papilio glaucus
eastern tiger swallowtail - (species)
Published - Accepted by Curator
CYP6BG1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Unknown
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Li X; Shan C; Li F ; et al. (2019)
Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resista[...]
1 Additional References
GP00002064
CYP6BG1
A0A222NX20
Physiology
promoters tested in luciferase assays
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
CYP6BG1
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
CYP6CM1
Xenobiotic resistance (insecticide; imidacloprid)
Cis-regulatory,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Karunker I; Benting J; Lueke B ; et al. (2008)
Over-expression of cytochrome P450 CYP6CM1 is associated with high resistance to imidacloprid in the[...]
GP00002608
A0A6C0PTH9
Physiology
three single-nucleotide polymorphic (SNP) markers in the intron region of CYP6CM1 that discriminate between the resistant and susceptible CYP6CM1 alleles
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
CYP6CM1
Bemisia tabaci
(species)
Published - Accepted by Curator
CYP6CY3
Xenobiotic resistance (insecticide; neonicotinoid; host plant)
Cis-regulatory,
Insertion
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Bass C; Zimmer CT; Riveron JM ; et al. (2013)
Gene amplification and microsatellite polymorphism underlie a recent insect host shift.
1 Additional References
GP00001474
CYP6CY3
V5SQ25
Physiology
Expansion of a AC dinucleotide microsatellite (from 15 to 48 repeat units) in the promoter 198 bp upstream of the start codon that enhances gene expression
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
CYP6CY3
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
CYP6CY3-CYP6CY4
Xenobiotic resistance (insecticide; neonicotinoid; host plant)
Gene Amplification,
Insertion
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Bass C; Zimmer CT; Riveron JM ; et al. (2013)
Gene amplification and microsatellite polymorphism underlie a recent insect host shift.
3 Additional References
GP00001473
CYP6CY3
V5SQ25
Physiology
gene amplification (from 2 to 14-100 copies) - CYP6CY3 and neighboring gene CYP6CY4 are duplicated in M. p. nicotianae as a large amplicon of ~325 kb creating characteristic breakpoints identifying the region. CYP6CY4 and CYP6CY3 are highly effective at metabolizing nicotine to its nontoxic metabolite cotinine.
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
CYP6CY3-CYP6CY4
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
CYP6D1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Gao J; Scott JG (2006)
Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the hou[...]
GP00002118
CYP6D1
Q27698
Physiology
15 bp insertion which disrupts a putative mdGfi-1 binding site in the CYP6D1v1 promoter. mdGfi-1 is a negative regulator of transcription so this leads to increased expression of CYP6D1
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
CYP6D1
Musca domestica
house fly - (species)
Published - Accepted by Curator
cyp6d2
Xenobiotic resistance (chemotherapeutic agent, camptothecin)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Thomas AM; Hui C; South A ; et al. (2013)
Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]
GP00001983
Cyp6g2
Q9V675
Physiology
G>C in CATAGgtaagga...caagCTCT so that intron 3 is not spliced and the codon GCT (spanning the intron) is transformed into CCT. The splicing is defective and intron 3 is transcribed and results in a stop codon and a protein truncated from its native C terminal part.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
cyp6d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
cyp6d2
Xenobiotic resistance (chemotherapeutic agent, camptothecin)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Thomas AM; Hui C; South A ; et al. (2013)
Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]
GP00001984
Cyp6g2
Q9V675
Physiology
N438T (A22652974C) and N439T (A22652978G) - exact causing mutation(s) not identified - semiquantitative RT-PCR revealed that this mutant produces little to no Cyp6d2 transcript. The mutation is thus also cis-regulatory.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
cyp6d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Coding,
SNP
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002472
cyp6er1
A0A2I8B6P1
Physiology
T318S substitution results in a marked (20-fold) and significant increase in resistance compared to the wild-type susceptible variant.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Coding,
Deletion
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002473
cyp6er1
A0A2I8B6P1
Physiology
Deletion of Pro377. This provides a more moderate but significant 4.5-fold increase in resistance.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Coding,
Complex Change
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002474
cyp6er1
A0A2I8B6P1
Physiology
A375del+A376G
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Cis-regulatory,
Unknown
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002475
cyp6er1
A0A2I8B6P1
Physiology
A significant (up to 9.5-fold) increase in expression driven by the promoter of CYP6ER1vA was observed in comparison to all other promoter variants. This suggests that cis-acting elements in the region upstream of CYP6ER1vA are responsible for the high expression of this variant in BPH populations across Southeast Asia.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6FU1
Xenobiotic resistance (insecticide; deltamethrin)
Cis-regulatory,
Unknown
Laodelphax striatellus
small brown planthopper - (species) D
Intraspecific
Candidate Gene
Pu J; Sun H; Wang J ; et al. (2016)
Multiple cis-acting elements involved in up-regulation of a cytochrome P450 gene conferring resistan[...]
GP00002117
CYP6FU1
A0A1S5R631
Physiology
Four cis-acting elements were identified whose influence on up-regulation was much more pronounced in combination than when present singly.
Laodelphax striatellus
small brown planthopper - (species)
Laodelphax striatellus
small brown planthopper - (species) D
CYP6FU1
Laodelphax striatellus
small brown planthopper - (species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
4 Mutations:
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Chung H; Bogwitz MR; McCart C ; et al. (2007)
Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]
GP00000207
Cyp6g1
Q9V674
Physiology
4 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
cyp6g1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Schlenke TA; Begun DJ (2004)
Strong selective sweep associated with a transposon insertion in Drosophila simulans.
GP00002019
Cyp6g1
Q9V674
Physiology
insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene
Drosophila simulans
(species)
Drosophila simulans
(species) D
cyp6g1
Drosophila simulans
(species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013)
Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]
GP00002020
Cyp6g1
Q9V674
Physiology
insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene
Drosophila simulans
(species)
Drosophila simulans
(species) D
cyp6g1
Drosophila simulans
(species)
Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)
Xenobiotic resistance (insecticide)
Cis-regulatory,
Unknown
Anopheles funestus
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Riveron JM; Irving H; Ndula M ; et al. (2013)
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...]
1 Additional References
GP00000208
CYP2C9
P11712
Physiology
Cis-regulatory variation in CYP6P9b gene
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species) D
CYP6P9 cluster (CYP6P9a and CYP6P9b)
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
CYP6P9; CYP6P4 cluster
Xenobiotic resistance (insecticide)
5 Mutations:
Anopheles funestus
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Wondji CS; Irving H; Morgan J ; et al. (2009)
Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...]
2 Additional References
GP00000209
Q2YH43
Physiology
5 mutations
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species) D
CYP6P9; CYP6P4 cluster
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
CYP79D15
Toxicity levels (cyanogenic glucoside)
Gene Loss,
Deletion
N
Trifolium repens
white clover - (species) D
Intraspecific
Linkage Mapping
Olsen KM; Hsu SC; Small LL (2008)
Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...]
1 Additional References
GP00000211
CYP79D15
B2Y2T9
Physiology
Gene deletion N
Trifolium repens
white clover - (species)
Trifolium repens
white clover - (species) D
CYP79D15
Trifolium repens
white clover - (species)
Published - Accepted by Curator
CYP81F2
Glucosinolate content
Herbivore resistance (aphids)
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Pfalz M; Vogel H; Kroymann J (2009)
The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole gluco[...]
GP00000212
CYP81F2
Q9LVD6
Physiology
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CYP81F2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CYP9A
Xenobiotic resistance (insecticide; deltamethrin)
Gene Amplification,
Insertion
Spodoptera frugiperda
fall armyworm - (species)
Intraspecific
Association Mapping
Gimenez S; Abdelgaffar H; Goff GL ; et al. (2020)
Adaptation by copy number variation increases insecticide resistance in the fall armyworm.
GP00002476
Physiology
In sensitive alleles the gene cluster is composed of 12 CYP9A genes and two alcohol dehydrogenase genes. All 30 resistant alleles have two copies of this unit while 28 and 6 alleles of the sensitive individuals had one and two copies; respectively.
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species)
CYP9A
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
CYP9A186
Xenobiotic resistance (insecticide; avermectin; emamectin benzoate; abamectin)
Coding,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Linkage Mapping
Zuo Y; Shi Y; Zhang F ; et al. (2021)
Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in[...]
GP00002393
CYP9A186
A0A8E4AAI2
Physiology
Heterologous expression and in vitro functional assays further confirm that a natural substitution (F116V) found in the substrate recognition site 1 (SRS1) of the CYP9A186 protein results in enhanced metabolism of EB and abamectin
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
CYP9A186
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
CYP9J26
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Bariami V; Jones CM; Poupardin R ; et al. (2012)
Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]
GP00002606
CYP9J
Q8T4S7
Physiology
CYP9J26 gene amplified about 6–7 times
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
CYP9J26
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
CYP9M6
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Aedes aegypti
yellow fever mosquito - (species) D
Experimental Evolution
Candidate Gene
Kasai S; Komagata O; Itokawa K ; et al. (2014)
Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insens[...]
1 Additional References
GP00002448
CYP9M6
X5ICI6
Physiology
CYP9M6 has the capability to metabolize permethrin and is over expressed in the resistant strain partially due to gene amplification. The average copy number of the CYP9M9 gene is 4.6-fold more than the standard strain based on qPCR.
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
CYP9M6
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)
Coding,
SNP
Plasmopara viticola
(species) D
Intraspecific
Candidate Gene
Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007)
At least two origins of fungicide resistance in grapevine downy mildew populations.
GP00002041
UQCRFS1
P47985
Physiology
Gly143Ala G1256C
Plasmopara viticola
(species)
Plasmopara viticola
(species) D
cytochrome b
Plasmopara viticola
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)
Coding,
SNP
Plasmopara viticola
(species) D
Intraspecific
Candidate Gene
Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007)
At least two origins of fungicide resistance in grapevine downy mildew populations.
GP00002042
UQCRFS1
P47985
Physiology
Gly143Ala G1256C
Plasmopara viticola
(species)
Plasmopara viticola
(species) D
cytochrome b
Plasmopara viticola
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; myxothiazol)
Coding,
SNP
Chlamydomonas reinhardtii
(species) D
Intraspecific
Candidate Gene
Bennoun P; Delosme M; Kück U (1991)
Mitochondrial genetics of Chlamydomonas reinhardtii: resistance mutations marking the cytochrome b g[...]
GP00002043
UQCRFS1
P47985
Physiology
F129L
Chlamydomonas reinhardtii
(species)
Chlamydomonas reinhardtii
(species) D
cytochrome b
Chlamydomonas reinhardtii
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)
2 Mutations:
Coding
SNP
Mycena galopus
(species) D
Interspecific
Candidate Gene
Kraiczy P; Haase U; Gencic S ; et al. (1996)
The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]
GP00002044
UQCRFS1
P47985
Physiology
2 mutations
Mycena viridimarginata
(species)
Mycena galopus
(species) D
cytochrome b
Mycena galopus
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)
2 Mutations:
Coding
SNP
Strobilurus tenacellus
(species) D
Interspecific
Candidate Gene
Kraiczy P; Haase U; Gencic S ; et al. (1996)
The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]
GP00002045
UQCRFS1
P47985
Physiology
2 mutations
Mycena viridimarginata
(species)
Strobilurus tenacellus
(species) D
cytochrome b
Strobilurus tenacellus
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting)
Coding,
SNP
Schizosaccharomyces pombe
fission yeast - (species) D
Interspecific
Candidate Gene
Kraiczy P; Haase U; Gencic S ; et al. (1996)
The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-produc[...]
GP00002046
UQCRFS1
P47985
Physiology
N261D
Saccharomyces cerevisiae
baker's yeast - (species)
Schizosaccharomyces pombe
fission yeast - (species) D
cytochrome b
Schizosaccharomyces pombe
fission yeast - (species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (insecticide ; bifenazate)
2 Mutations:
Coding
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Interspecific
Candidate Gene
Van Leeuwen T; Vanholme B; Van Pottelberge S ; et al. (2008)
Mitochondrial heteroplasmy and the evolution of insecticide resistance: non-Mendelian inheritance in[...]
GP00002599
UQCRFS1
P47985
Physiology
2 mutations
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
cytochrome b
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (insecticide ; bifenazate)
2 Mutations:
Coding
SNP
Panonychus citri
citrus red mite - (species) D
Interspecific
Candidate Gene
Van Leeuwen T; Van Nieuwenhuyse P; Vanholme B ; et al. (2011)
Parallel evolution of cytochrome b mediated bifenazate resistance in the citrus red mite Panonychus [...]
GP00002600
UQCRFS1
P47985
Physiology
2 mutations
Panonychus citri
citrus red mite - (species)
Panonychus citri
citrus red mite - (species) D
cytochrome b
Panonychus citri
citrus red mite - (species)
Published - Accepted by Curator
cytochrome c oxidase (COX7A)
Fertility
Lifespan
Locomotor activity
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Melvin RG; Katewa SD; Ballard JW (2008)
A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...]
1 Additional References
GP00001980
COX7A
Q9VHS2
Physiology
Physiology
Physiology
Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.
Drosophila simulans
(species)
Drosophila simulans
(species) D
cytochrome c oxidase (COX7A)
Drosophila simulans
(species)
Published - Accepted by Curator
D14 (KAI2 paralog)
Seed dormancy (strigolactone responsiveness)
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species) D
Intergeneric or Higher
Candidate Gene
Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015)
PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]
GP00000213
D14
Q10QA5
Physiology
Ligand-binding pocket tuning
Spermatophyta
(no rank)
Arabidopsis thaliana
thale cress - (species) D
D14 (KAI2 paralog)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Darkener of apricot (Doa)
Lifespan
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Hoedjes KM; Kostic H; Keller L ; et al. (2022)
Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity.
GP00002662
Doa
P49762
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Darkener of apricot (Doa)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
DCAF17
Hair Length
Unknown,
Unknown
Sus scrofa
pig - (species) D
Domesticated
Association Mapping
Ai H; Fang X; Yang B ; et al. (2015)
Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequen[...]
GP00001570
DCAF17
I3LQF0
Physiology
Sus scrofa
pig - (species)
Sus scrofa
pig - (species) D
DCAF17
Sus scrofa
pig - (species)
Published - Accepted by Curator
DEEPER ROOTING 1
Drought tolerance
Root growth
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Uga Y; Sugimoto K; Ogawa S ; et al. (2013)
Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought condition[...]
GP00000215
Dro1
Q69P88
Physiology
Morphology
1bp deletion within exon 4 N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
DEEPER ROOTING 1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Delta-1-pyrroline-5-carboxylate synthase A
Drought response (drought-induced proline accumulation)
2 Mutations:
Coding
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Kesari R; Lasky JR; Villamor JG ; et al. (2012)
Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation[...]
GP00001280
P5CSA
P54887
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Delta-1-pyrroline-5-carboxylate synthase A
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
dentin sialophosphoprotein (DSPP)
Tooth absence (no enamel production)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001936
DSPP
Q9NZW4
Physiology
synteny of the corresponding region - only the N-terminal region of DSPP is present in the genome - 1-bp deletion in exon one leading to a reading frame shift were this sequence to be translated N
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
dentin sialophosphoprotein (DSPP)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
DEP1 (DENSE AND ERECT PANICLES 1)
Nitrogen use (metabolism)
Coding,
SNP
Oryza sativa Japonica Group
Japanese rice - (no rank)
Domesticated
Linkage Mapping
Sun H; Qian Q; Wu K ; et al. (2014)
Heterotrimeric G proteins regulate nitrogen-use efficiency in rice.
GP00001376
P0046G12.12-1
Q67UU9
Physiology
p.Cys105Tyr affecting affinity interaction between the GGL domain of DEP1 and RGB1 subunit
Oryza sativa Indica Group
long-grained rice - (no rank)
Oryza sativa Japonica Group
Japanese rice - (no rank)
DEP1 (DENSE AND ERECT PANICLES 1)
Oryza sativa Japonica Group
Japanese rice - (no rank)
Published - Accepted by Curator
desatF
Pheromone production
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Interspecific
Candidate Gene
Legendre A; Miao XX; Da Lage JL ; et al. (2008)
Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and court[...]
1 Additional References
GP00000219
desatF
A7DZ97
Physiology
Enrichment/gain of DSX binding sites
Drosophila
(subgenus)
Drosophila melanogaster
fruit fly - (species)
desatF
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
desatF
Pheromone production
Cis-regulatory,
Deletion
Drosophila
(subgenus) D
Interspecific
Candidate Gene
Shirangi TR; Dufour HD; Williams TM ; et al. (2009)
Rapid evolution of sex pheromone-producing enzyme expression in Drosophila.
GP00000220
desatF
A7DZ97
Physiology
Inactivation of DSX-binding site
Drosophila takahashii
(species)
Drosophila
(subgenus) D
desatF
Drosophila
(subgenus)
Published - Accepted by Curator
desaturase 2 (desat2)
Pheromone production
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Takahashi A; Tsaur SC; Coyne JA ; et al. (2001)
The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila m[...]
1 Additional References
GP00000221
Desat2
Q9VG68
Physiology
16bp deletion about 150bp upstream of transcription start site
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
desaturase 2 (desat2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
diacylglycerol acyltransferase 1 (DGAT1)
Milk fat content
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Grisart B; Coppieters W; Farnir F ; et al. (2002)
Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the [...]
1 Additional References
GP00000222
Dgat1
Q9Z2A7
Physiology
K232A
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
diacylglycerol acyltransferase 1 (DGAT1)
Bos taurus
cattle - (species)
Published - Accepted by Curator
diacylglycerol acyltransferase 1-2 (DGAT1-2)
Oil composition
Oil yield
Coding,
Deletion
Zea mays
(species) D
Domesticated
Linkage Mapping
Zheng P; Allen WB; Roesler K ; et al. (2008)
A phenylalanine in DGAT is a key determinant of oil content and composition in maize.
GP00000223
DGAT1-2
B0LF77
Physiology
Physiology
Deletion of amino acid F469
Zea mays
(species)
Zea mays
(species) D
diacylglycerol acyltransferase 1-2 (DGAT1-2)
Zea mays
(species)
Published - Accepted by Curator
Dihydrofolate reductase (pvdhfr)
Xenobiotic resistance (pyrimethamine)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species) D
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001484
DHFR
P00374
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species) D
Dihydrofolate reductase (pvdhfr)
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
Dihydropteroate synthase (pvdhps)
Xenobiotic resistance (sulfadoxine)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001485
DHPS
Q00LX9
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species)
Dihydropteroate synthase (pvdhps)
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
Diptericin
Pathogen resistance (bacteria)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Unckless RL; Rottschaefer SM; Lazzaro BP (2015)
The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster.
1 Additional References
GP00000227
DptA
P24492
Physiology
Ser>Arg (AGC>AGA)
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Diptericin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Diptericin
Pathogen resistance (bacteria)
Coding,
SNP
Drosophila simulans
(species)
Intraspecific
Candidate Gene
Unckless RL; Howick VM; Lazzaro BP (2016)
Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.
1 Additional References
GP00000228
DptA
P24492
Physiology
Ser>Arg (AGC>AGG)
Drosophila simulans
(species)
Drosophila simulans
(species)
Diptericin
Drosophila simulans
(species)
Published - Accepted by Curator
Distorter on the X (Dox)
Sex determination (sex ratio distortion)
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Tao Y; Araripe L; Kingan SB ; et al. (2007)
A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.
GP00001969
Physiology
Deletion of 105bp, resulting in the loss of exon III, which deletes one of the 42bp elements that is tandemly repeated in wild-type Dsim\Dox.
Drosophila simulans
(species)
Drosophila simulans
(species) D
Distorter on the X (Dox)
Drosophila simulans
(species)
Published - Accepted by Curator
DNA replication factor CDT1
Resistance to UV irradiation
Coding,
SNP
Rhinopithecus strykeri
Burmese snub-nosed monkey - (species) D
Rhinopithecus bieti
black snub-nosed monkey - (species) D
Interspecific
Association Mapping
Yu L; Wang GD; Ruan J ; et al. (2016)
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]
GP00001507
CDT1
Q9H211
Physiology
p.Ala537Val
Rhinopithecus avunculus
Tonkin snub-nosed monkey - (species)
Rhinopithecus strykeri
Burmese snub-nosed monkey - (species) D
Rhinopithecus bieti
black snub-nosed monkey - (species) D
DNA replication factor CDT1
Rhinopithecus strykeri
Burmese snub-nosed monkey - (species)
Rhinopithecus bieti
black snub-nosed monkey - (species)
Published - Accepted by Curator
DNA replication factor CDT1 [[likely pseudo-replicate of other CDT1 entry by introgression]]
Resistance to UV irradiation
Coding,
SNP
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
Interspecific
Association Mapping
Yu L; Wang GD; Ruan J ; et al. (2016)
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]
GP00001508
CDT1
Q9H211
Physiology
p.Ala537Val
Rhinopithecus brelichi
Gray snub-nosed monkey - (species)
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
DNA replication factor CDT1 [[likely pseudo-replicate of other CDT1 entry by introgression]]
Rhinopithecus roxellana
golden snub-nosed monkey - (species)
Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)
Seed dormancy
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Bentsink L; Jowett J; Hanhart CJ ; et al. (2006)
Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis.
3 Additional References
GP00000231
DOG1
A0SVK0
Physiology
Not identified (possibly polyallelic as each cross to the Ler accession showed different DOG1 effects)
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
DOG1 (DELAY OF GERMINATION 1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)
Seed dormancy
Cis-regulatory,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Kerdaffrec E; Filiault DL; Korte A ; et al. (2016)
Multiple alleles at a single locus control seed dormancy in Swedish Arabidopsis.
GP00001397
DOG1
A0SVK0
Physiology
At least 3 haplotypes defined by 4 SNPs in a putative regulatory region of DOG-1.
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
DOG1 (DELAY OF GERMINATION 1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Dopa oxidase-3 (Dox-3)
Enzymatic activity
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Asada N (1997)
Genetic variants affecting phenoloxidase activity in Drosophila melanogaster.
GP00002000
Physiology
Exact causing mutation(s) unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Dopa oxidase-3 (Dox-3)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Dopa-decarboxylase
Lifespan
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
De Luca M; Roshina NV; Geiger-Thornsberry GL ; et al. (2003)
Dopa decarboxylase (Ddc) affects variation in Drosophila longevity.
GP00000233
Ddc
P05031
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Dopa-decarboxylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
drh-1
Pathogen resistance (viral immunity)
Coding,
Deletion
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Ashe A; Bélicard T; Le Pen J ; et al. (2013)
A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and an[...]
GP00001308
drh-1
G5EDI8
Physiology
159 base deletion in CDS resulting in truncated but potentially non-null protein
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
drh-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Drip
Fertility
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Bergland AO; Chae HS; Kim YJ ; et al. (2012)
Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression an[...]
GP00000237
Drip
Q9V5Z7
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Drip
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Drosomycin-like 5
Pathogen resistance (fungi)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002111
Drsl5
Q9VZR2
Physiology
Duplication of the gene and insertion of a 4993-bp region (which comes from part of a neighboring gene). Associated with a >1000-fold expression increase of the gene.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Drosomycin-like 5
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ds1
Pathogen resistance
Unknown,
Unknown
Sorghum bicolor
sorghum - (species)
Domesticated
Linkage Mapping
Kawahigashi H; Kasuga S; Ando T ; et al. (2011)
Positional cloning of ds1, the target leaf spot resistance gene against Bipolaris sorghicola in sorg[...]
GP00000238
ds1
K0IXC4
Physiology
unknown
Sorghum bicolor
sorghum - (species)
Sorghum bicolor
sorghum - (species)
ds1
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
DTH2
Flowering time
2 Mutations:
Coding
SNP
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Wu W; Zheng XM; Lu G ; et al. (2013)
Association of functional nucleotide polymorphisms at DTH2 with the northward expansion of rice cult[...]
GP00000239
DTH2
O82118
Physiology
2 mutations
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
DTH2
Oryza sativa
rice - (species)
Published - Accepted by Curator
Duffy
Pathogen resistance (Plasmodium; malaria parasite) (malaria)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Tournamille C; Colin Y; Cartron JP ; et al. (1995)
Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-n[...]
GP00000240
ACKR1
Q16570
Physiology
T to C substitution in 5' region at pos -46
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Duffy
Homo sapiens
human - (species)
Published - Accepted by Curator
E2F1
Silk yield
Cis-regulatory,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Tong X; Han MJ; Lu K ; et al. (2022)
High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]
GP00002400
E2f1
Q27368
Physiology
There are one deletion and three insertions in the cis-regulatory region and introns of the E2F1 gene of the improved strain. Higher expression in the improves strain. CRISPR-cas9 mediated knockout of BmE2F1 reduces the number of silk gland cells by 7.68% and silk yield by 22%.
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
E2F1
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
EARLY FLOWERING 3 (here = Mat-a)
Flowering time
Coding,
Deletion
N
Hordeum vulgare
(species) D
Domesticated
Linkage Mapping
Zakhrabekova S; Gough SP; Braumann I ; et al. (2012)
Induced mutations in circadian clock regulator Mat-a facilitated short-season adaptation and range e[...]
GP00000243
ELF3
O82804
Physiology
4bp deletion resulting in truncated protein ; this deletion seem to have evolved multiple times (fragile site?) N
Hordeum vulgare
(species)
Hordeum vulgare
(species) D
EARLY FLOWERING 3 (here = Mat-a)
Hordeum vulgare
(species)
Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)
Flowering time
Coding,
Indel
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Jiménez-Gómez JM; Wallace AD; Maloof JN (2010)
Network analysis identifies ELF3 as a QTL for the shade avoidance response in Arabidopsis.
3 Additional References
GP00000244
ELF3
O82804
Physiology
Background-dependent effects of extensive polyQ coding variation
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
EARLY FLOWERING 3(ELF3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)
Flowering time (latitudinal adaptation)
Coding,
Deletion
N
Glycine max
soybean - (species) D
Domesticated
Linkage Mapping
Lu S; Zhao X; Hu Y ; et al. (2017)
Natural variation at the soybean J locus improves adaptation to the tropics and enhances yield.
GP00001683
CYP75B1
Q9SD85
Physiology
recessive allele responsible for the LJ trait - 10-bp deletion predicted to cause a frameshift resulting in premature termination of translation after 195 amino acids in the 714-amino-acid protein N
Glycine max
soybean - (species)
Glycine max
soybean - (species) D
EARLY FLOWERING 3(ELF3)
Glycine max
soybean - (species)
Published - Accepted by Curator
EARLY FLOWERING 3/ EARLY MATURITY 8
Flowering time
Coding,
SNP
N
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Faure S; Turner AS; Gruszka D ; et al. (2012)
Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]
GP00000245
ELF3
O82804
Physiology
Premature stop codon; C-to-T point mutation in exon 2 N
Hordeum vulgare
(species)
Hordeum vulgare
(species)
EARLY FLOWERING 3/ EARLY MATURITY 8
Hordeum vulgare
(species)
Published - Accepted by Curator
EARLY FLOWERING 3/ EARLYMATURITY8
Flowering time
Coding,
Deletion
N
Hordeum vulgare
(species) D
Domesticated
Linkage Mapping
Faure S; Turner AS; Gruszka D ; et al. (2012)
Mutation at the circadian clock gene EARLY MATURITY 8 adapts domesticated barley (Hordeum vulgare) t[...]
GP00000246
ELF3
O82804
Physiology
4bp deletion resulting in truncated protein ; this deletion seem to have evolved multiple times (fragile site?) N
Hordeum vulgare
(species)
Hordeum vulgare
(species) D
EARLY FLOWERING 3/ EARLYMATURITY8
Hordeum vulgare
(species)
Published - Accepted by Curator
EARLY FLOWERING 3/Hd17
Flowering time
Unknown,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Matsubara K; Ogiso-Tanaka E; Hori K ; et al. (2012)
Natural variation in Hd17, a homolog of Arabidopsis ELF3 that is involved in rice photoperiodic flow[...]
GP00000247
ELF3
O82804
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
EARLY FLOWERING 3/Hd17
Oryza sativa
rice - (species)
Published - Accepted by Curator
Early flowering1 (EL1)
Flowering time (heading date)
Coding,
SNP
Oryza sativa Japonica Group
Japanese rice - (no rank) D
Domesticated
Linkage Mapping
Kwon CT; Yoo SC; Koo BH ; et al. (2014)
Natural variation in Early flowering1 contributes to early flowering in japonica rice under long day[...]
GP00001636
HD16
Q852L0
Physiology
G476C p.Gly159Ala in the serine/threonine kinase domain leading to non-functional protein
Oryza sativa
rice - (species)
Oryza sativa Japonica Group
Japanese rice - (no rank) D
Early flowering1 (EL1)
Oryza sativa Japonica Group
Japanese rice - (no rank)
Published - Accepted by Curator
Early flowering1 (EL1)
Flowering time (heading date)
Coding,
SNP
Oryza sativa Japonica Group
Japanese rice - (no rank) D
Domesticated
Linkage Mapping
Kwon CT; Yoo SC; Koo BH ; et al. (2014)
Natural variation in Early flowering1 contributes to early flowering in japonica rice under long day[...]
GP00001637
HD16
Q852L0
Physiology
G991A p.Ala331Thr in the serine/threonine kinase domain leading to non-functional protein
Oryza sativa
rice - (species)
Oryza sativa Japonica Group
Japanese rice - (no rank) D
Early flowering1 (EL1)
Oryza sativa Japonica Group
Japanese rice - (no rank)
Published - Accepted by Curator
early responsive to dehydration stress protein 4
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001434
ERD4
Q9C8G5
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
early responsive to dehydration stress protein 4
Arabidopsis arenosa
(species)
Published - Accepted by Curator
EBF1
Body fat distribution (pericardial)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001554
EBF1
Q9UH73
Physiology
A>G & T>G in 2 associated SNPs
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EBF1
Homo sapiens
human - (species)
Published - Accepted by Curator
Ecdysone oxidase
Developmental time
Cis-regulatory,
Insertion
Bombyx mori
domestic silkworm - (species) D
Domesticated
Candidate Gene
Sun W; Shen YH; Han MJ ; et al. (2014)
An adaptive transposable element insertion in the regulatory region of the EO gene in the domesticat[...]
1 Additional References
GP00001102
Eo
Q9VY01
Physiology
insertion of a 512bp fragment of a Taguchi transposable element 462 bp upstream of the transcription start site of the EO gene. The TE insertion enhances the transcription of flanking genes after 20-hydroxyecdysone treatment.
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
Ecdysone oxidase
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
EDN3
Coloration (coat)
Coloration (eyes)
Hearing (loss)
Unknown,
Unknown
Lama glama
llama - (species) D
Vicugna pacos
alpaca - (species) D
Domesticated
Candidate Gene
Fan R; Gu Z; Guang X ; et al. (2020)
Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca.
GP00002182
EDN3
P14138
Morphology
Morphology
Physiology
Introgression from alpacas to lamas and clear correlation wit phenotype but no information on the mutation(s)
Vicugna vicugna
vicugna - (species)
Lama glama
llama - (species) D
Vicugna pacos
alpaca - (species) D
EDN3
Lama glama
llama - (species)
Vicugna pacos
alpaca - (species)
Published - Accepted by Curator
EGLN1
Hypoxia response
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Simonson TS; Yang Y; Huff CD ; et al. (2010)
Genetic evidence for high-altitude adaptation in Tibet.
3 Additional References
GP00000261
EGLN1
Q9GZT9
Physiology
possibly D4E
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
EGLN1
Homo sapiens
human - (species)
Published - Accepted by Curator
EGLN1
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Bigham A; Bauchet M; Pinto D ; et al. (2010)
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...]
GP00000262
EGLN1
Q9GZT9
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EGLN1
Homo sapiens
human - (species)
Published - Accepted by Curator
EGLN1
Hypoxia response
Coding,
SNP
Panthera uncia
snow leopard - (species) D
Interspecific
Association Mapping
Cho YS; Hu L; Hou H ; et al. (2013)
The tiger genome and comparative analysis with lion and snow leopard genomes.
GP00001358
EGLN1
Q9GZT9
Physiology
p.Met39Lys
Panthera
(genus)
Panthera uncia
snow leopard - (species) D
EGLN1
Panthera uncia
snow leopard - (species)
Published - Accepted by Curator
EGLN1
Hypoxia response
Coding,
SNP
Heterocephalus glaber
naked mole-rat - (species) D
Interspecific
Association Mapping
Kim EB; Fang X; Fushan AA ; et al. (2011)
Genome sequencing reveals insights into physiology and longevity of the naked mole rat.
GP00001759
EGLN1
Q9GZT9
Physiology
unique amino-acid changes in different positions of EGLN1 (Pro15, Arg17 and Arg36)
Rodentia
rodent - (order)
Heterocephalus glaber
naked mole-rat - (species) D
EGLN1
Heterocephalus glaber
naked mole-rat - (species)
Published - Accepted by Curator
EGLN1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002135
EGLN1
Q9GZT9
Physiology
Physiology
probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
EGLN1
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
EGLN1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas georgica
yellow-billed pintail - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002136
EGLN1
Q9GZT9
Physiology
Physiology
probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst
Anas georgica
yellow-billed pintail - (species)
Anas georgica
yellow-billed pintail - (species) D
EGLN1
Anas georgica
yellow-billed pintail - (species)
Published - Accepted by Curator
EGNL1
High-altitude adaptation
Hypoxia response
Cis-regulatory,
Unknown
Anas cyanoptera
cinnamon teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002134
EGLN1
Q9GZT9
Physiology
Physiology
probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst
Anas cyanoptera
cinnamon teal - (species)
Anas cyanoptera
cinnamon teal - (species) D
EGNL1
Anas cyanoptera
cinnamon teal - (species)
Published - Accepted by Curator
Ehd1 (Response regulator)
Flowering time
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Doi K; Izawa T; Fuse T ; et al. (2004)
Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-[...]
GP00000263
EHD1
Q9H4M9
Physiology
G218R in highly conserved region in GARP domain
Oryza glaberrima
African rice - (species)
Oryza sativa
rice - (species)
Ehd1 (Response regulator)
Oryza sativa
rice - (species)
Published - Accepted by Curator
ENA1-2-5 cluster
Salt tolerance (experimental evolution)
Gene Amplification,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species)
Experimental Evolution
Association Mapping
Anderson JB; Funt J; Thompson DA ; et al. (2010)
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...]
1 Additional References
GP00000265
ENA1
P13587
Physiology
uncharacterized expansion
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
ENA1-2-5 cluster
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ENA1-2-5 cluster
Salt tolerance (experimental evolution)
Gene Amplification,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000266
ENA1
P13587
Physiology
uncharacterized expansion
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ENA1-2-5 cluster
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth absence (no enamel production)
Gene Loss,
Deletion
N
Gallus gallus
chicken - (species) D
Intergeneric or Higher
Candidate Gene
Sire JY; Delgado SC; Girondot M (2008)
Hen's teeth with enamel cap: from dream to impossibility.
GP00001935
ENAM
Q9NRM1
Physiology
synteny of the corresponding region - the gene has been likely deleted from the chicken genome as a consequence of intrachromosomal rearrangements which have probably occurred in the lineage that led to the last common ancestor of modern birds N
Paleosuchus palpebrosus
Cuvier's dwarf caiman - (species)
Gallus gallus
chicken - (species) D
enamelin (ENAM)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth absence (no enamel production)
Coding,
Deletion
N
Eubalaena glacialis
North Atlantic right whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
Eschrichtius robustus
grey whale - (species) D
Caperea marginata
pygmy right whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
1 Additional References
GP00001939
ENAM
Q9NRM1
Physiology
1-bp deletion. Various frameshift mutations were found in the distinct species. N
Cetacea
whales - (order)
Eubalaena glacialis
North Atlantic right whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
Eschrichtius robustus
grey whale - (species) D
Caperea marginata
pygmy right whale - (species) D
enamelin (ENAM)
Eubalaena glacialis
North Atlantic right whale - (species)
Megaptera novaeangliae
humpback whale - (species)
Eschrichtius robustus
grey whale - (species)
Caperea marginata
pygmy right whale - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
2 Mutations:
Coding
Deletion
N
Kogia sima
dwarf sperm whale - (species) D
Kogia breviceps
pygmy sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
1 Additional References
GP00001942
ENAM
Q9NRM1
Physiology
2 mutations
Physeter catodon
sperm whale - (species)
Kogia sima
dwarf sperm whale - (species) D
Kogia breviceps
pygmy sperm whale - (species) D
enamelin (ENAM)
Kogia sima
dwarf sperm whale - (species)
Kogia breviceps
pygmy sperm whale - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
3 Mutations:
Coding
N
Orycteropus afer
aardvark - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
GP00001943
ENAM
Q9NRM1
Physiology
3 mutations
Elephantulus rufescens
East African long-eared elephant shrew - (species)
Orycteropus afer
aardvark - (species) D
enamelin (ENAM)
Orycteropus afer
aardvark - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
Coding,
Unknown
N
Manis pentadactyla
Chinese pangolin - (species) D
Manis tricuspis
Tree pangolin - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
GP00001944
ENAM
Q9NRM1
Physiology
multiple deletions and insertions less than 9bp causing frameshift N
Canis lupus familiaris
dog - (subspecies)
Manis pentadactyla
Chinese pangolin - (species) D
Manis tricuspis
Tree pangolin - (species) D
enamelin (ENAM)
Manis pentadactyla
Chinese pangolin - (species)
Manis tricuspis
Tree pangolin - (species)
Published - Accepted by Curator
enamelin (ENAM)
Tooth composition (no enamel production)
Coding,
Unknown
N
Bradypus tridactylus
Pale-throated sloth - (species) D
Tamandua tetradactyla
southern tamandua - (species) D
Dasypus novemcinctus
nine-banded armadillo - (species) D
Euphractus sexcinctus
(species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Murphy WJ ; et al. (2009)
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of[...]
GP00001945
ENAM
Q9NRM1
Physiology
multiple frameshift insertions and deletions N
Canis lupus familiaris
dog - (subspecies)
Bradypus tridactylus
Pale-throated sloth - (species) D
Tamandua tetradactyla
southern tamandua - (species) D
Dasypus novemcinctus
nine-banded armadillo - (species) D
Euphractus sexcinctus
(species) D
enamelin (ENAM)
Bradypus tridactylus
Pale-throated sloth - (species)
Tamandua tetradactyla
southern tamandua - (species)
Dasypus novemcinctus
nine-banded armadillo - (species)
Euphractus sexcinctus
(species)
Published - Accepted by Curator
enamelysin (MMP20)
Tooth absence (no enamel production)
Coding,
Insertion
N
Balaenoptera physalus
Fin whale - (species) D
Balaena mysticetus
bowhead whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Cheng J ; et al. (2011)
Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]
GP00001940
MMP20
O60882
Physiology
insertion of a CHR-2 SINE retroposon in exon 2 of MMP20 which would result in premature truncation of the MMP20 protein owing to stop codons in all possible reading frames of the CHR-2 SINE. The length of the MMP20 SINE ranges from 302 bp (B. musculus) to 318 bp (B. physalus). This mutation is found in eight investigated species of baleen whales. Other inactivating mutations (nonsense and frameshift mutations) are found in various species N
Physeter catodon
sperm whale - (species)
Balaenoptera physalus
Fin whale - (species) D
Balaena mysticetus
bowhead whale - (species) D
Megaptera novaeangliae
humpback whale - (species) D
enamelysin (MMP20)
Balaenoptera physalus
Fin whale - (species)
Balaena mysticetus
bowhead whale - (species)
Megaptera novaeangliae
humpback whale - (species)
Published - Accepted by Curator
enamelysin (MMP20)
Tooth composition (no enamel production)
Coding,
SNP
N
Kogia breviceps
pygmy sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Cheng J ; et al. (2011)
Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales[...]
GP00001941
MMP20
O60882
Physiology
opal stop codon (TGA) in the propeptide-coding region of MMP20 exon 2 in a single individual of the pygmy sperm whale Kogia breviceps N
Kogia sima
dwarf sperm whale - (species)
Kogia breviceps
pygmy sperm whale - (species) D
enamelysin (MMP20)
Kogia breviceps
pygmy sperm whale - (species)
Published - Accepted by Curator
END3
Temperature tolerance
Virulence
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
1 Additional References
GP00000267
END3
P39013
Physiology
Physiology
S258N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
END3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
END3
Temperature tolerance
Virulence
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
1 Additional References
GP00000268
END3
P39013
Physiology
Physiology
D268N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
END3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Enhanced shoot growth under mannitol stress 2 (EGM2)
Plant growth (shoot growth under stress)
2 Mutations:
Coding
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Trontin C; Kiani S; Corwin JA ; et al. (2014)
A pair of receptor-like kinases is responsible for natural variation in shoot growth response to man[...]
GP00001630
At1g11300
Q9SXB4
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Enhanced shoot growth under mannitol stress 2 (EGM2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ENSA
Body fat distribution (pericardial)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001558
ENSA
O43768
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ENSA
Homo sapiens
human - (species)
Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)
Increase in antiviral ribonuclease activity
Coding,
SNP
Catarrhini
(parvorder)
Intergeneric or Higher
Candidate Gene
Zhang J; Rosenberg HF (2002)
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.
GP00000272
RNASE2
P10153
Physiology
Arg64Ser
Primates
(order)
Catarrhini
(parvorder)
eosinophil-derived neurotoxin (EDN)
Catarrhini
(parvorder)
Published - Accepted by Curator
eosinophil-derived neurotoxin (EDN)
Increase in antiviral ribonuclease activity
Coding,
SNP
Catarrhini
(parvorder)
Intergeneric or Higher
Candidate Gene
Zhang J; Rosenberg HF (2002)
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.
GP00000273
RNASE2
P10153
Physiology
Thr132Arg
Primates
(order)
Catarrhini
(parvorder)
eosinophil-derived neurotoxin (EDN)
Catarrhini
(parvorder)
Published - Accepted by Curator
EPAS1
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Simonson TS; Yang Y; Huff CD ; et al. (2010)
Genetic evidence for high-altitude adaptation in Tibet.
1 Additional References
GP00000274
EPAS1
Q99814
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EPAS1
Homo sapiens
human - (species)
Published - Accepted by Curator
EPAS1
Hypoxia response
Coding,
SNP
Panthera uncia
snow leopard - (species) D
Interspecific
Association Mapping
Cho YS; Hu L; Hou H ; et al. (2013)
The tiger genome and comparative analysis with lion and snow leopard genomes.
GP00001357
EPAS1
Q99814
Physiology
two species-specific amino acid changes: Val663Ile and Cys794Arg - whether both or only one is affecting the phenotype is unknown
Panthera
(genus)
Panthera uncia
snow leopard - (species) D
EPAS1
Panthera uncia
snow leopard - (species)
Published - Accepted by Curator
EPAS1
Hypoxia response
Coding,
SNP
Peromyscus maniculatus
North American deer mouse - (species) D
Intraspecific
Association Mapping
Schweizer RM; Velotta JP; Ivy CM ; et al. (2019)
Physiological and genomic evidence that selection on the transcription factor Epas1 has altered card[...]
GP00002062
EPAS1
Q99814
Physiology
non-synonymous polymorphism located at site 755 in the 14th exon that changes threonine to methionine Thr755Met
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species) D
EPAS1
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
EPAS1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas cyanoptera
cinnamon teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002131
EPAS1
Q99814
Physiology
Physiology
several candidate coding mutations
Anas cyanoptera
cinnamon teal - (species)
Anas cyanoptera
cinnamon teal - (species) D
EPAS1
Anas cyanoptera
cinnamon teal - (species)
Published - Accepted by Curator
EPAS1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002132
EPAS1
Q99814
Physiology
Physiology
several candidate coding mutations
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
EPAS1
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
EPAS1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas georgica
yellow-billed pintail - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002133
EPAS1
Q99814
Physiology
Physiology
several candidate coding mutations
Anas georgica
yellow-billed pintail - (species)
Anas georgica
yellow-billed pintail - (species) D
EPAS1
Anas georgica
yellow-billed pintail - (species)
Published - Accepted by Curator
Epithiospecifier Modifier1 (ESM1)
Nitrile content
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Zhang Z; Ober JA; Kliebenstein DJ (2006)
The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hy[...]
GP00000277
ESM1
Q9LJG3
Physiology
Not identified
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Epithiospecifier Modifier1 (ESM1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Epithiospecifier protein (ESP)
Plant secondary metabolite (glucosinolate)
Herbivore resistance
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001)
The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]
GP00000278
ESP
Q8RY71
Physiology
Physiology
Not identified
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Epithiospecifier protein (ESP)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Epithiospecifier protein (ESP)
Plant secondary metabolite (glucosinolate)
Herbivore resistance
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001)
The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]
GP00000279
ESP
Q8RY71
Physiology
Physiology
deletion of 124 bases that eliminates a splice site and 100 nucleotides of the ORF N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Epithiospecifier protein (ESP)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Amaranthus palmeri
(species) D
Intraspecific
Candidate Gene
Gaines TA; Zhang W; Wang D ; et al. (2010)
Gene amplification confers glyphosate resistance in Amaranthus palmeri.
GP00001883
At2g45300
P05466
Physiology
Genomes of resistant plants contain from 5-fold to more than 160-fold more copies of the EPSPS gene than did genomes of susceptible plants - the duplicated section of DNA including the 10 kb EPSPS gene is at least 30 kb long
Amaranthus palmeri
(species)
Amaranthus palmeri
(species) D
EPSPS
Amaranthus palmeri
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Amaranthus tuberculatus
(species) D
Intraspecific
Candidate Gene
Tranel PJ; Riggins CW; Bell MS ; et al. (2011)
Herbicide resistances in Amaranthus tuberculatus: a call for new options.
GP00001884
At2g45300
P05466
Physiology
4 copies of the EPSPS gene
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
EPSPS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Lolium multiflorum
Italian ryegrass - (species) D
Intraspecific
Candidate Gene
Salas RA; Dayan FE; Pan Z ; et al. (2012)
EPSPS gene amplification in glyphosate-resistant Italian ryegrass (Lolium perenne ssp. multiflorum) [...]
GP00001885
At2g45300
P05466
Physiology
15-25 copies of the EPSPS gene
Lolium multiflorum
Italian ryegrass - (species)
Lolium multiflorum
Italian ryegrass - (species) D
EPSPS
Lolium multiflorum
Italian ryegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Bassia scoparia
(species) D
Intraspecific
Candidate Gene
Sammons RD; Gaines TA (2014)
Glyphosate resistance: state of knowledge.
GP00001886
At2g45300
P05466
Physiology
15-25 copies of the EPSPS gene
Bassia scoparia
(species)
Bassia scoparia
(species) D
EPSPS
Bassia scoparia
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Amaranthus spinosus
(species) D
Intraspecific
Candidate Gene
Sammons RD; Gaines TA (2014)
Glyphosate resistance: state of knowledge.
GP00001887
At2g45300
P05466
Physiology
26-37 copies of the EPSPS gene
Amaranthus spinosus
(species)
Amaranthus spinosus
(species) D
EPSPS
Amaranthus spinosus
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Eleusine indica
goosegrass - (species) D
Intraspecific
Candidate Gene
Baerson SR; Rodriguez DJ; Tran M ; et al. (2002)
Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshik[...]
GP00001888
At2g45300
P05466
Physiology
Pro106Ser leading to 2-4-fold resistance
Eleusine indica
goosegrass - (species)
Eleusine indica
goosegrass - (species) D
EPSPS
Eleusine indica
goosegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Echinochloa colona
(species) D
Intraspecific
Candidate Gene
Morran S; Moretti ML; Brunharo CA ; et al. (2018)
Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]
GP00001889
At2g45300
P05466
Physiology
Pro106Ser leading to resistance
Echinochloa colona
(species)
Echinochloa colona
(species) D
EPSPS
Echinochloa colona
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Echinochloa colona
(species) D
Intraspecific
Candidate Gene
Morran S; Moretti ML; Brunharo CA ; et al. (2018)
Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]
GP00001890
At2g45300
P05466
Physiology
Pro106Leu leading to resistance
Echinochloa colona
(species)
Echinochloa colona
(species) D
EPSPS
Echinochloa colona
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Echinochloa colona
(species) D
Intraspecific
Candidate Gene
Morran S; Moretti ML; Brunharo CA ; et al. (2018)
Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]
GP00001891
At2g45300
P05466
Physiology
Pro106Thr leading to resistance
Echinochloa colona
(species)
Echinochloa colona
(species) D
EPSPS
Echinochloa colona
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Candidate Gene
Bell Michael S; Hager Aaron G; Tranel Patrick J (2013
)
Multiple resistance to herbicides from four site-of-action groups in waterhemp (Amaranthus tubercula[...]
GP00001892
At2g45300
P05466
Physiology
resistance not due to EPSPS amplification; partly due to P106S mutation
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
EPSPS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium multiflorum
Italian ryegrass - (species) D
Intraspecific
Candidate Gene
Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008
)
Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]
GP00001896
At2g45300
P05466
Physiology
Pro106Ser
Lolium multiflorum
Italian ryegrass - (species)
Lolium multiflorum
Italian ryegrass - (species) D
EPSPS
Lolium multiflorum
Italian ryegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium multiflorum
Italian ryegrass - (species) D
Intraspecific
Candidate Gene
Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008
)
Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]
GP00001897
At2g45300
P05466
Physiology
Pro106Ala conferring 5-15-fold resistance
Lolium multiflorum
Italian ryegrass - (species)
Lolium multiflorum
Italian ryegrass - (species) D
EPSPS
Lolium multiflorum
Italian ryegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Eleusine indica
goosegrass - (species) D
Intraspecific
Candidate Gene
Ng CH; Wickneswari R; Salmijah S ; et al. (2003
)
Gene polymorphisms in glyphosate‐resistant and‐susceptible biotypes of Eleusine indica from Malaysia[...]
GP00001898
At2g45300
P05466
Physiology
Pro106Thr leading to 3-fold resistance
Eleusine indica
goosegrass - (species)
Eleusine indica
goosegrass - (species) D
EPSPS
Eleusine indica
goosegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Digitaria insularis
(species) D
Intraspecific
Candidate Gene
de Carvalho LB; Alves PL; González-Torralva F ; et al. (2012)
Pool of resistance mechanisms to glyphosate in Digitaria insularis.
GP00001899
At2g45300
P05466
Physiology
Pro106Thr
Digitaria insularis
(species)
Digitaria insularis
(species) D
EPSPS
Digitaria insularis
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Kaundun SS; Dale RP; Zelaya IA ; et al. (2011)
A novel P106L mutation in EPSPS and an unknown mechanism(s) act additively to confer resistance to g[...]
GP00001900
At2g45300
P05466
Physiology
Pro106Leu conferring a 1.7-fold resistance increase to glyphosate at the whole plant level
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012
)
Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]
GP00001901
At2g45300
P05466
Physiology
Pro106Ser
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012
)
Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]
GP00001902
At2g45300
P05466
Physiology
Pro106Thr
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Yu Q; Cairns A; Powles S (2007)
Glyphosate, paraquat and ACCase multiple herbicide resistance evolved in a Lolium rigidum biotype.
GP00001903
At2g45300
P05466
Physiology
Pro106Ala
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
ERECTA
Plant architecture
Leaf architecture
Transpiration
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Masle J; Gilmore SR; Farquhar GD (2005)
The ERECTA gene regulates plant transpiration efficiency in Arabidopsis.
2 Additional References
GP00000280
ERECTA
Q42371
Morphology
Morphology
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ERECTA
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ERECTA
Pathogen resistance (Cucumerina fungus)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Llorente F; Alonso-Blanco C; Sánchez-Rodriguez C ; et al. (2005)
ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resistanc[...]
GP00001244
ERECTA
Q42371
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ERECTA
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000281
ERG11
P10613
Physiology
Y132H
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000282
ERG11
P10613
Physiology
S405F
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000283
ERG11
P10613
Physiology
G464S
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000284
ERG11
P10613
Physiology
R467K
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
Indel
Candida albicans
(species)
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00000285
ERG11
P10613
Physiology
Copy number Variant
Candida albicans
(species)
Candida albicans
(species)
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00000286
ERG3
P32353
Physiology
Arg63Stop A187T in line 21 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001744
ERG3
P32353
Physiology
Ser76Stop C227A in line 22 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001745
ERG3
P32353
Physiology
Ser95Stop C284A in line 23 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001746
ERG3
P32353
Physiology
Trp205Stop G615A in line 24 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001747
ERG3
P32353
Physiology
Trp205Stop G615A in line 25 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001748
ERG3
P32353
Physiology
Trp205Stop G615A in line 26 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001749
ERG3
P32353
Physiology
Trp205Stop G615A in line 27 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
Insertion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001750
ERG3
P32353
Physiology
29-bp duplication in line 28 at nucleotide position 641 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001751
ERG3
P32353
Physiology
Trp219Stop G656A in line 29 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001752
ERG3
P32353
Physiology
Gly235Ser G703A in line 30 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001753
ERG3
P32353
Physiology
Tyr299Stop C897A in line 31 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001754
ERG3
P32353
Physiology
Gly300Arg G898C in line 32 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001755
ERG3
P32353
Physiology
Asp307Ala A920C in line 33 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001756
ERG3
P32353
Physiology
1-bp deletion in line 34
A980- N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG3
Xenobiotic resistance (drug)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00001757
ERG3
P32353
Physiology
60-bp deletion at position 253 in line 35 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG5
Xenobiotic resistance (drug)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00000287
ERG5
P54781
Physiology
60bp deletion N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG5
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG6
Xenobiotic resistance (drug)
Coding,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00000288
erg6
O14321
Physiology
7 unique mutations in ERG6 within a total 19 lines ; 4 of these mutations evolved multiple times
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
ERG6
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ERG7
Xenobiotic resistance (drug)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Lo DS; Otto SP (2012)
Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of[...]
GP00000289
ERG7
P38604
Physiology
Phe699Leu
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
ERG7
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
esterase A8 and B8
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Qiao CL; Marquine M; Pasteur N ; et al. (1998)
A new esterase gene amplification involved in OP resistance in Culex pipiens mosquitoes from China.
GP00002641
B1
P16854
Physiology
coamplification of both esterase loci (Est-2 and Est-3)
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
esterase A8 and B8
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
esterase B1
Xenobiotic resistance (insecticide; benzoylurea)
Gene Amplification,
Complex Change
Culex tritaeniorhynchus
(species) D
Intraspecific
Candidate Gene
Karunaratne SH; Vaughan A; Paton MG ; et al. (1998)
Amplification of a serine esterase gene is involved in insecticide resistance in Sri Lankan Culex tr[...]
GP00000290
B1
P16854
Physiology
Whole gene amplification
Culex tritaeniorhynchus
(species)
Culex tritaeniorhynchus
(species) D
esterase B1
Culex tritaeniorhynchus
(species)
Published - Accepted by Curator
esterase B1 + esterase A
Xenobiotic resistance (insecticide)
Gene Amplification,
Complex Change
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Rooker S; Guillemaud T; Bergé J ; et al. (1996)
Coamplification of esterase A and B genes as a single unit in Culex pipiens mosquitoes.
GP00000291
B1
P16854
Physiology
Amplification of a region containing both genes
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
esterase B1 + esterase A
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
esterase B1 = esterase beta1
Xenobiotic resistance (insecticide)
Gene Amplification,
Complex Change
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Mouchès C; Pasteur N; Bergé JB ; et al. (1986)
Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mo[...]
3 Additional References
GP00000292
B1
P16854
Physiology
Amplification of esterase B1 only
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
esterase B1 = esterase beta1
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
esterase B4
Xenobiotic resistance (insecticide; chlorpyrifos)
Gene Amplification,
Insertion
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Poirié M; Raymond M; Pasteur N (1992)
Identification of two distinct amplifications of the esterase B locus in Culex pipiens (L.) mosquito[...]
GP00002639
B1
P16854
Physiology
The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
esterase B4
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
esterase B5
Xenobiotic resistance (insecticide; chlorpyrifos)
Gene Amplification,
Insertion
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Poirié M; Raymond M; Pasteur N (1992)
Identification of two distinct amplifications of the esterase B locus in Culex pipiens (L.) mosquito[...]
GP00002640
B1
P16854
Physiology
The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
esterase B5
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
esterase E4
Xenobiotic resistance (insecticide)
Gene Amplification,
Complex Change
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Field LM; Devonshire AL; Forde BG (1988)
Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results[...]
2 Additional References
GP00000293
P35501
Physiology
Whole gene amplification. Amplification of the E4 gene is closely linked to a chromosomal translocation (the autosomal 1-3 translocation event) and amplified genes are situated at a single heterozygous site on autosome 3 as a tandem array of head-to-tail amplicons.
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
esterase E4
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
esterase FE4
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Blackman RL; Spence JM; Field LM ; et al. (1999
)
Variation in the chromosomal distribution of amplified esterase (FE4) genes in Greek field populatio[...]
2 Additional References
GP00002642
P35502
Physiology
Gene amplification
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
esterase FE4
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia cuprina
Australian sheep blowfly - (species)
Intraspecific
Candidate Gene
Newcomb RD; Campbell PM; Ollis DL ; et al. (1997)
A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]
GP00000294
LcaE7
Q25252
Physiology
Gly137Asp
Lucilia cuprina
Australian sheep blowfly - (species)
Lucilia cuprina
Australian sheep blowfly - (species)
esterase isozyme E3
Lucilia cuprina
Australian sheep blowfly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia cuprina
Australian sheep blowfly - (species)
Intraspecific
Candidate Gene
Jackson CJ; Liu JW; Carr PD ; et al. (2013)
Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]
GP00000295
LcaE7
Q25252
Physiology
Trp251Leu
Lucilia cuprina
Australian sheep blowfly - (species)
Lucilia cuprina
Australian sheep blowfly - (species)
esterase isozyme E3
Lucilia cuprina
Australian sheep blowfly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia sericata
common green bottle fly - (species)
Intraspecific
Candidate Gene
Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006)
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]
GP00000296
LcaE7
Q25252
Physiology
Trp251Leu
Lucilia sericata
common green bottle fly - (species)
Lucilia sericata
common green bottle fly - (species)
esterase isozyme E3
Lucilia sericata
common green bottle fly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia sericata
common green bottle fly - (species) D
Intraspecific
Candidate Gene
Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006)
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]
GP00000297
LcaE7
Q25252
Physiology
Trp251Ser
Lucilia sericata
common green bottle fly - (species)
Lucilia sericata
common green bottle fly - (species) D
esterase isozyme E3
Lucilia sericata
common green bottle fly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia sericata
common green bottle fly - (species) D
Intraspecific
Candidate Gene
Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006)
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]
GP00000298
LcaE7
Q25252
Physiology
Gly137Asp
Lucilia sericata
common green bottle fly - (species)
Lucilia sericata
common green bottle fly - (species) D
esterase isozyme E3
Lucilia sericata
common green bottle fly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Cochliomyia hominivorax
primary screw-worm - (species) D
Intraspecific
Candidate Gene
da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011)
Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]
2 Additional References
GP00002584
alphaE7
A0A0G3Z837
Physiology
G137D
Cochliomyia hominivorax
primary screw-worm - (species)
Cochliomyia hominivorax
primary screw-worm - (species) D
esterase isozyme E3
Cochliomyia hominivorax
primary screw-worm - (species)
Published - Accepted by Curator
esterase isozyme E7 = E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Claudianos C; Russell RJ; Oakeshott JG (1999)
The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]
GP00000299
LcaE7
Q25252
Physiology
Gly137Asp
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
esterase isozyme E7 = E3
Musca domestica
house fly - (species)
Published - Accepted by Curator
esterase NI-EST1
Xenobiotic resistance (organophosphorus insecticides)
Gene Amplification,
Insertion
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Small GJ; Hemingway J (2000)
Molecular characterization of the amplified carboxylesterase gene associated with organophosphorus i[...]
GP00002638
Ces1
Q8VCC2
Physiology
Southern analysis of genomic DNA from the Sri Lankan OP-resistant and susceptible strains suggests that the Nl-EST1 esterase gene is amplified in the resistant strain
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
esterase NI-EST1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
esterase type I
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Schizaphis graminum
greenbug - (species) D
Intraspecific
Candidate Gene
Ono M; Swanson JJ; Field LM ; et al. (1999)
Amplification and methylation of an esterase gene associated with insecticide-resistance in greenbug[...]
1 Additional References
GP00002637
P35501
Physiology
The type I esterase is amplified 4- to 8-fold in resistant S. graminum and that the amplified sequences contain 5-methylcytosine at MspI/HpaII sites.
Schizaphis graminum
greenbug - (species)
Schizaphis graminum
greenbug - (species) D
esterase type I
Schizaphis graminum
greenbug - (species)
Published - Accepted by Curator
eve
Developmental time
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Palsson A; Wesolowska N; Reynisdóttir S ; et al. (2014)
Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.
GP00001986
eve
P06602
Physiology
72bp deletion that removes one of the hb protein-binding sites in the stripe 3+7 enhancer of eve. The deletion also removes half of a putative slp1 protein-binding site.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
eve
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
F2RL2
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001617
F2RL2
O00254
Physiology
A>T at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
F2RL2
Homo sapiens
human - (species)
Published - Accepted by Curator
FAD2 (BnaA.FAD2.a)
Oil composition
Oil yield
Coding,
Insertion
N
Brassica napus
rape - (species) D
Domesticated
Linkage Mapping
Yang Q; Fan C; Guo Z ; et al. (2012)
Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific ma[...]
GP00000302
FAD2
P46313
Physiology
Physiology
4bp insertion resulting in frameshift and premature stop codon N
Brassica napus
rape - (species)
Brassica napus
rape - (species) D
FAD2 (BnaA.FAD2.a)
Brassica napus
rape - (species)
Published - Accepted by Curator
FAD2A
Oil composition (oleate levels)
Coding,
SNP
N
Arachis hypogaea
peanut - (species) D
Domesticated
Candidate Gene
Jung S; Powell G; Moore K ; et al. (2000)
The high oleate trait in the cultivated peanut [Arachis hypogaea L]. II. Molecular basis and genetic[...]
GP00002075
FAD2A
E2GJC1
Physiology
D150N in a residue that is absolutely conserved among other desaturases N
Arachis hypogaea
peanut - (species)
Arachis hypogaea
peanut - (species) D
FAD2A
Arachis hypogaea
peanut - (species)
Published - Accepted by Curator
FAD2B
Oil composition (oleate levels)
Coding,
Insertion
N
Arachis hypogaea
peanut - (species) D
Domesticated
Candidate Gene
Patel M; Jung S; Moore K ; et al. (2004)
High-oleate peanut mutants result from a MITE insertion into the FAD2 gene.
GP00002073
FAD2B
Q9LKK6
Physiology
insertion of 205-bp miniature inverted-repeat transposable element (MITE) called ahMITE1 at position 665 near the center of the coding region in the case of MF; which causes a frameshift N
Arachis hypogaea
peanut - (species)
Arachis hypogaea
peanut - (species) D
FAD2B
Arachis hypogaea
peanut - (species)
Published - Accepted by Curator
FAD2B
Oil composition (oleate levels)
Coding,
Insertion
N
Arachis hypogaea
peanut - (species) D
Domesticated
Candidate Gene
Patel M; Jung S; Moore K ; et al. (2004)
High-oleate peanut mutants result from a MITE insertion into the FAD2 gene.
GP00002074
FAD2B
Q9LKK6
Physiology
insertion of 205-bp miniature inverted-repeat transposable element (MITE) called ahMITE1 at position 997 of the coding region; which causes a frameshift N
Arachis hypogaea
peanut - (species)
Arachis hypogaea
peanut - (species) D
FAD2B
Arachis hypogaea
peanut - (species)
Published - Accepted by Curator
Fads2
Fatty acid metabolism (fatty acid desaturation)
Gene Amplification,
Insertion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Interspecific
Linkage Mapping
Ishikawa A; Kabeya N; Ikeya K ; et al. (2019)
A key metabolic gene for recurrent freshwater colonization and radiation in fishes.
GP00001959
fads2
Q9DEX7
Physiology
Fads2 locus is duplicated in G. aculeatus increasing DHA intake and the propensity to invade of freshwater environments. The ancestral copy is on linkage group 19 and the derived copy is on linkage group 12.
Gasterosteus nipponicus
(species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
Fads2
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Fads2
Fatty acid metabolism (fatty acid desaturation)
Gene Amplification,
Insertion
Pungitius tymensis
Sakhalin sticlkeback - (species) D
Pungitius kaibarae
(species) D
Interspecific
Candidate Gene
Ishikawa A; Kabeya N; Ikeya K ; et al. (2019)
A key metabolic gene for recurrent freshwater colonization and radiation in fishes.
GP00002053
fads2
Q9DEX7
Physiology
higher number of copies of Fads2.
Pungitius pungitius
ninespine stickleback - (species)
Pungitius tymensis
Sakhalin sticlkeback - (species) D
Pungitius kaibarae
(species) D
Fads2
Pungitius tymensis
Sakhalin sticlkeback - (species)
Pungitius kaibarae
(species)
Published - Accepted by Curator
FaO-methyl-transferase (FaOMT)
Fragrance (flavor)
Cis-regulatory,
Unknown
Fragaria x ananassa
strawberry - (species)
Domesticated
Linkage Mapping
Zorrilla-Fontanesi Y; Rambla JL; Cabeza A ; et al. (2012)
Genetic analysis of strawberry fruit aroma and identification of O-methyltransferase FaOMT as the lo[...]
GP00000303
omt1
Q9M602
Physiology
Promoter variation _ there are several single nucleotide polymorphisms (SNPs); insertion/deletions (indels); and rearrangements in the promoter
Fragaria x ananassa
strawberry - (species)
Fragaria x ananassa
strawberry - (species)
FaO-methyl-transferase (FaOMT)
Fragaria x ananassa
strawberry - (species)
Published - Accepted by Curator
FAR (pheromone gland FAR)
Pheromone production (isomeric/chirality divergence)
Coding,
Unknown
Ostrinia nubilalis
European corn borer - (species)
Intraspecific
Linkage Mapping
Lassance JM; Groot AT; Liénard MA ; et al. (2010)
Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones.
2 Additional References
GP00000304
pgFAR
D3U9W3
Physiology
Candidate a.a. substitutions with effect validated in vitro
Ostrinia nubilalis
European corn borer - (species)
Ostrinia nubilalis
European corn borer - (species)
FAR (pheromone gland FAR)
Ostrinia nubilalis
European corn borer - (species)
Published - Accepted by Curator
fatty acid synthase
Dessication tolerance
Pheromone production (mbCHC)
Cis-regulatory,
Unknown
Drosophila birchii
(species)
Interspecific
Candidate Gene
Chung H; Loehlin DW; Dufour HD ; et al. (2014)
A single gene affects both ecological divergence and mate choice in Drosophila.
GP00002063
FASN3
Q7PLB8
Physiology
Physiology
No expression of the gene in D. birchii. The coding region of the D. birchii gene is intact. Cis-regulatory region tested in reporter assays in D. melanogaster - exact causing mutation(s) unknown. RNAi against mFAS/CG17354 in D. serrata recapitylates the D. birchii phenotype.
Drosophila serrata
(species)
Drosophila birchii
(species)
fatty acid synthase
Drosophila birchii
(species)
Published - Accepted by Curator
fatty acyl-CoA reductase FAR2-B
Pheromone production (cuticular hydrocarbons)
Unknown,
Unknown
Drosophila serrata
(species)
Intraspecific
Linkage Mapping
Rusuwa BB; Chung H; Allen SL ; et al. (2022)
Natural variation at a single gene generates sexual antagonism across fitness components in Drosophi[...]
GP00002395
Dmel\CG17560
Q9VES6
Physiology
Both alleles of DsFAR2-B appear to be functional. The distinction between the two alleles iss a large number of non-synonymous substitutions.
Drosophila serrata
(species)
Drosophila serrata
(species)
fatty acyl-CoA reductase FAR2-B
Drosophila serrata
(species)
Published - Accepted by Curator
ferredoxin
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001530
PF3D7_1318100
Q8IED5
Physiology
p.Asp193Tyr
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
ferredoxin
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
Ferroportin 2
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001437
IREG2
F4KGN5
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
Ferroportin 2
Arabidopsis arenosa
(species)
Published - Accepted by Curator
fibrinogen-related protein 1 (FREP1)
Pathogen resistance (Plasmodium; malaria parasite)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Li J; Wang X; Zhang G ; et al. (2013)
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]
GP00001465
3290292
Q5TWN1
Physiology
c.T1325A p.Q442L
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
fibrinogen-related protein 1 (FREP1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
fibrinogen-related protein 30 (FBN30)
Pathogen resistance (parasite)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Li J; Wang X; Zhang G ; et al. (2013)
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]
GP00001464
1270165
Q7QIK0
Physiology
c.T28C p.F10L
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
fibrinogen-related protein 30 (FBN30)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Fidgetin-like1 (Fignl1)
Testis size (testis weight ; spermatogenesis)
Unknown,
Unknown
Mus musculus
house mouse - (species)
Interspecific
Linkage Mapping
L'Hôte D; Vatin M; Auer J ; et al. (2011)
Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced tes[...]
GP00001668
Fignl1
Q8BPY9
Physiology
Several non-synonymous SNPs and an alternative splicing encoding a truncated isoform that may act as a competitor of the full length protein in the degradation process
Mus spretus
western wild mouse - (species)
Mus musculus
house mouse - (species)
Fidgetin-like1 (Fignl1)
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Fkh
Silk yield
Cis-regulatory,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xia Q; Guo Y; Zhang Z ; et al. (2009)
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).
GP00002411
fkh
P14734
Physiology
Increased expression in high yield strains. The Fkh gene encodes a transcription factor that activates glue genes together with Sage in salivary glands of Drosophila melanogaster.
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
Fkh
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
Flavonoid 3'-5'-hydroxylase (F3'5'H)
Plant secondary metabolite (catechin)
Unknown,
Unknown
Camellia sinensis
(species)
Intraspecific
Linkage Mapping
Jin JQ; Ma JQ; Yao MZ ; et al. (2017)
Functional natural allelic variants of flavonoid 3',5'-hydroxylase gene governing catechin traits in[...]
GP00001620
F3'5'H1
A3KLR7
Physiology
several candidate SNPs
Camellia sinensis
(species)
Camellia sinensis
(species)
Flavonoid 3'-5'-hydroxylase (F3'5'H)
Camellia sinensis
(species)
Published - Accepted by Curator
FLC (=Pep1)
Flowering time
Gene Amplification,
Indel
Arabis alpina
gray rockcress - (species)
Intraspecific
Candidate Gene
Albani MC; Castaings L; Wötzel S ; et al. (2012)
PEP1 of Arabis alpina is encoded by two overlapping genes that contribute to natural genetic variati[...]
GP00000329
FLC
Q9S7Q7
Physiology
complex structural variations
Arabis alpina
gray rockcress - (species)
Arabis alpina
gray rockcress - (species)
FLC (=Pep1)
Arabis alpina
gray rockcress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005)
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions.
1 Additional References
GP00000330
FLC
Q9S7Q7
Physiology
Substitution creating premature Stop (codon 158) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
2 Mutations:
Cis-regulatory
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Coustham V; Li P; Strange A ; et al. (2012)
Quantitative modulation of polycomb silencing underlies natural variation in vernalization.
1 Additional References
GP00000331
FLC
Q9S7Q7
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Insertion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Michaels SD; He Y; Scortecci KC ; et al. (2003)
Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...]
3 Additional References
GP00000332
FLC
Q9S7Q7
Physiology
TE insertion in intron 1; a region required for normal FLC regulation. The transposable element renders FLC-Ler subject to repressive chromatin modifications mediated by short interfering RNAs generated from homologous transposable elements in the genome.
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Michaels SD; He Y; Scortecci KC ; et al. (2003)
Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...]
1 Additional References
GP00000333
FLC
Q9S7Q7
Physiology
Not identified
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005)
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions.
1 Additional References
GP00000334
FLC
Q9S7Q7
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005)
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions.
1 Additional References
GP00000335
FLC
Q9S7Q7
Physiology
GA substitution disrupting Splice Site
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Sánchez-Bermejo E; Méndez-Vigo B; Picó FX ; et al. (2012)
Novel natural alleles at FLC and LVR loci account for enhanced vernalization responses in Arabidopsi[...]
1 Additional References
GP00000336
FLC
Q9S7Q7
Physiology
50bp deletion in 5'UTR
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Coding,
SNP
Capsella rubella
(species)
Intraspecific
Linkage Mapping
Guo YL; Todesco M; Hagmann J ; et al. (2012)
Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella[...]
GP00000337
FLC
Q9S7Q7
Physiology
Splice site mutation introducing frameshift; removing the last 35 of 198 amino acids
Capsella rubella
(species)
Capsella rubella
(species)
FLC (Flowering Locus C)
Capsella rubella
(species)
Published - Accepted by Curator
FLC-1
Flowering time
Coding,
SNP
Brassica rapa
field mustard - (species)
Domesticated
Linkage Mapping
Yuan YX; Wu J; Sun RF ; et al. (2009)
A naturally occurring splicing site mutation in the Brassica rapa FLC1 gene is associated with varia[...]
GP00000338
FLC
Q9S7Q7
Physiology
GA substitution disrupting Splice Site
Brassica rapa
field mustard - (species)
Brassica rapa
field mustard - (species)
FLC-1
Brassica rapa
field mustard - (species)
Published - Accepted by Curator
FLC-2
Flowering time
Coding,
Deletion
N
Brassica oleracea
wild cabbage - (species) D
Domesticated
Linkage Mapping
Okazaki K; Sakamoto K; Kikuchi R ; et al. (2007)
Mapping and characterization of FLC homologs and QTL analysis of flowering time in Brassica oleracea[...]
GP00000339
FLC
Q9S7Q7
Physiology
1bp deletion resulting in frameshift N
Brassica oleracea
wild cabbage - (species)
Brassica oleracea
wild cabbage - (species) D
FLC-2
Brassica oleracea
wild cabbage - (species)
Published - Accepted by Curator
FLC-2
Flowering time
Cis-regulatory,
Unknown
Brassica rapa
field mustard - (species)
Domesticated
Linkage Mapping
Zhao J; Kulkarni V; Liu N ; et al. (2010)
BrFLC2 (FLOWERING LOCUS C) as a candidate gene for a vernalization response QTL in Brassica rapa.
GP00000340
FLC
Q9S7Q7
Physiology
unknown
Brassica rapa
field mustard - (species)
Brassica rapa
field mustard - (species)
FLC-2
Brassica rapa
field mustard - (species)
Published - Accepted by Curator
FLM (MAF1)
Flowering time
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Warthmann N ; et al. (2005)
Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for[...]
GP00000341
AGL27
Q9AT76
Physiology
Deletion of entire gene N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLM (MAF1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLO1
Cell separation
Other,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Candidate Gene
Smukalla S; Caldara M; Pochet N ; et al. (2008)
FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast.
1 Additional References
GP00000342
FLO1
P32768
Physiology
both coding and non-coding divergence ; polyQ variation
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
FLO1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Flowering locus T (=HvFT=VRN3)
Flowering time
Cis-regulatory,
Unknown
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Yan L; Fu D; Li C ; et al. (2006)
The wheat and barley vernalization gene VRN3 is an orthologue of FT.
GP00000343
FT
Q9SXZ2
Physiology
Regulatory variation in first intron
Hordeum vulgare
(species)
Hordeum vulgare
(species)
Flowering locus T (=HvFT=VRN3)
Hordeum vulgare
(species)
Published - Accepted by Curator
Flowering locus T (=TaFT=VRN3)
Flowering time
Cis-regulatory,
Insertion
Triticum aestivum
bread wheat - (species) D
Domesticated
Linkage Mapping
Yan L; Fu D; Li C ; et al. (2006)
The wheat and barley vernalization gene VRN3 is an orthologue of FT.
GP00000344
FT
Q9SXZ2
Physiology
Retrotranspostion in promoter region
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species) D
Flowering locus T (=TaFT=VRN3)
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
Flowering locus T (FT)
Flowering time
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Domesticated
Linkage Mapping
Kojima S; Takahashi Y; Kobayashi Y ; et al. (2002)
Hd3a, a rice ortholog of the Arabidopsis FT gene, promotes transition to flowering downstream of Hd1[...]
1 Additional References
GP00000345
FT
Q9SXZ2
Physiology
Promoter region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Flowering locus T (FT)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Flowering locus T (FT1)
Flowering time
Coding,
Deletion
N
Helianthus annuus
common sunflower - (species) D
Domesticated
Linkage Mapping
Blackman BK; Strasburg JL; Raduski AR ; et al. (2010)
The role of recently derived FT paralogs in sunflower domestication.
GP00000346
FT
Q9SXZ2
Physiology
1bp deletion; frameshift N
Helianthus annuus
common sunflower - (species)
Helianthus annuus
common sunflower - (species) D
Flowering locus T (FT1)
Helianthus annuus
common sunflower - (species)
Published - Accepted by Curator
Flowering locus T (LpFT3)
Flowering time
Cis-regulatory,
Unknown
Lolium perenne
(species)
Domesticated
Candidate Gene
Skøt L; Sanderson R; Thomas A ; et al. (2011)
Allelic variation in the perennial ryegrass FLOWERING LOCUS T gene is associated with changes in flo[...]
GP00000347
FT
Q9SXZ2
Physiology
unknown
Lolium perenne
(species)
Lolium perenne
(species)
Flowering locus T (LpFT3)
Lolium perenne
(species)
Published - Accepted by Curator
FMN1
Recombination rate
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001662
FMN1
Q68DA7
Physiology
On chromosome 10. Associated SNP located upstream of the gene
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
FMN1
Bos taurus
cattle - (species)
Published - Accepted by Curator
FMO1
Xenobiotic resistance
Host plant specialization
Gene Amplification,
Complex Change
Tyria jacobaeae
cinnabar moth - (species)
Intergeneric or Higher
Candidate Gene
Sehlmeyer S; Wang L; Langel D ; et al. (2010)
Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arct[...]
GP00000348
Fmo-1
Q9W1E9
Physiology
Physiology
Gene duplication
Lepidoptera
butterflies and moths - (order)
Tyria jacobaeae
cinnabar moth - (species)
FMO1
Tyria jacobaeae
cinnabar moth - (species)
Published - Accepted by Curator
FMO2
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Mallott M; Hamm S; Troczka BJ ; et al. (2019)
A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]
GP00002065
FMO2
Q99518
Physiology
a putatative transposon (233bp) insertion in the HAW promoter sequence just 140 bp upstream of the start codon of PxFMO2 which was absent in the ROTH promoter, the boundaries of all copies of this element were found to be defined by 34 bp imperfect terminal inverted repeats, increase the expression of the gene PxFMO2 downstream
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
FMO2
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
fog-2
Fertility (self-fertility; hermaphrodite spermatogenesis)
Gene Amplification,
Complex Change
Caenorhabditis elegans
(species)
Interspecific
Candidate Gene
Nayak S; Goree J; Schedl T (2005)
fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis.
GP00000349
fog-2
Q2YS43
Physiology
Gene birth by duplication of an ancestral gene ; FOG-2 binds the translational regulator GLD-1 and promotes spermatogenesis ; see also tra-2 entry and associated references
Caenorhabditis briggsae
(species)
Caenorhabditis elegans
(species)
fog-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
FOXL2
Horns absence
Somatic sex change
Cis-regulatory,
Deletion
Capra hircus
goat - (species) D
Domesticated
Linkage Mapping
Pailhoux E; Vigier B; Chaffaux S ; et al. (2001)
A 11.7-kb deletion triggers intersexuality and polledness in goats.
2 Additional References
GP00000352
FOXL2
Q8MIP2
Morphology
Physiology
11.7 kbp deletion of mainly repetitive sequences ; Alters transcription of two flanking genes; but FOXL2 in particular is proposed as the main determinant of the phenotype
Capra hircus
goat - (species)
Capra hircus
goat - (species) D
FOXL2
Capra hircus
goat - (species)
Published - Accepted by Curator
FPN2
Metal tolerance
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Morrissey J; Baxter IR; Lee J ; et al. (2009)
The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.
GP00000354
IREG2
F4KGN5
Physiology
1bp insertion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
FPN2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FRD3 (FERRIC REDUCTASE DEFECTIVE3)
Metal tolerance
2 Mutations:
Coding
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Pineau C; Loubet S; Lefoulon C ; et al. (2012)
Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Z[...]
GP00000355
DTX43
Q9SFB0
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FRD3 (FERRIC REDUCTASE DEFECTIVE3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (BnaA.FRI.a)
Flowering time
Unknown,
Unknown
Brassica napus
rape - (species)
Domesticated
Linkage Mapping
Wang N; Qian W; Suppanz I ; et al. (2011)
Flowering time variation in oilseed rape (Brassica napus L.) is associated with allelic variation in[...]
GP00000356
FRI
P0DH90
Physiology
unknown
Brassica napus
rape - (species)
Brassica napus
rape - (species)
Frigida (BnaA.FRI.a)
Brassica napus
rape - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Johanson U; West J; Lister C ; et al. (2000)
Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]
GP00000357
FRI
P0DH90
Physiology
16bp deletion aa313-318 in exon 2 and premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Indel
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Johanson U; West J; Lister C ; et al. (2000)
Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]
1 Additional References
GP00000358
FRI
P0DH90
Physiology
376 bp deletion and 31 bp insertion that delete amino acid 1-15 and at best produce a 45-aa protein N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Indel
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000359
FRI
P0DH90
Physiology
Del 2257-2355 in exon 3; deletion of 99 bp combined with an insertion of 61 bp N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000360
FRI
P0DH90
Physiology
1bp deletion at 1487 in exon 1 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000361
FRI
P0DH90
Physiology
1bp insertion at 766 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
1 Additional References
GP00000362
FRI
P0DH90
Physiology
Insertion 1 bp at 1454 in exon 1 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000363
FRI
P0DH90
Physiology
Trp240* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000364
FRI
P0DH90
Physiology
Glu361* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Gazzani S; Gendall AR; Lister C ; et al. (2003)
Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.
GP00000365
FRI
P0DH90
Physiology
K232* in exon 1 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000366
FRI
P0DH90
Physiology
deletion; E430* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000367
FRI
P0DH90
Physiology
deletion of 6 amino acids; LQLDKE422-427*
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000368
FRI
P0DH90
Physiology
deletion aa 1-12
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000369
FRI
P0DH90
Physiology
deletion resulting in S121* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000370
FRI
P0DH90
Physiology
deletion; AF375-6* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000371
FRI
P0DH90
Physiology
insertion; I490* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000372
FRI
P0DH90
Physiology
insertion; T258* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000373
FRI
P0DH90
Physiology
Y162* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000374
FRI
P0DH90
Physiology
K170* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Water use efficiency
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Lovell JT; Juenger TE; Michaels SD ; et al. (2013)
Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation.
GP00000375
FRI
P0DH90
Physiology
Physiology
376 bp deletion within the promoter of the TSU-1 FRI allele
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida like 1 (FRL1)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Schläppi MR (2006)
FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]
GP00000376
FRL1
Q9FFF1
Physiology
E279* in the middle of the conceptual protein sequence N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida like 1 (FRL1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida like 2 (FRL2)
Flowering time
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Schläppi MR (2006)
FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]
GP00000377
FRL2
Q9C6S2
Physiology
A132P and/or L401Q
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida like 2 (FRL2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FRM2
Xenobiotic resistance (citrinin)
Cis-regulatory,
Unknown
Saccharomyces paradoxus
(species) D
Domesticated
Association Mapping
Naranjo S; Smith JD; Artieri CG ; et al. (2015)
Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.
GP00001311
FRM2
P37261
Physiology
mutations within 1kb in promotor region
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces paradoxus
(species) D
FRM2
Saccharomyces paradoxus
(species)
Published - Accepted by Curator
FTO
Body fat distribution (subcutaneous)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001560
FTO
Q9C0B1
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FTO
Homo sapiens
human - (species)
Published - Accepted by Curator
FUMARASE 2
Plant metabolism (fumarate/malate ratio)
Plant growth (bio-mass production)
Cis-regulatory,
Indel
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Riewe D; Jeon HJ; Lisec J ; et al. (2016)
A naturally occurring promoter polymorphism of the Arabidopsis FUM2 gene causes expression variation[...]
1 Additional References
GP00001286
FUM2
Q9FI53
Physiology
Physiology
2068 bp in promotor region @position -395. AND 3833bp in promotor region @position -1107
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FUMARASE 2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
1 Additional References
GP00000379
FUT2
Q10981
Physiology
9.3 kb deletion mediated by recombination between Alu sequences N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
2 Additional References
GP00000380
FUT2
Q10981
Physiology
10 kb deletion mediated by recombination between Alu sequences N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
SNP
N
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
1 Additional References
GP00000381
FUT2
Q10981
Physiology
premature stop at codon 143: TGG>TGA N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
1 Additional References
GP00000382
FUT2
Q10981
Physiology
Ile129Phe
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
G protein-coupled receptor rhodopsin
Diapause
Unknown,
Unknown
Daphnia magna
(species)
Intraspecific
Linkage Mapping
Roulin AC; Bourgeois Y; Stiefel U ; et al. (2016)
A Photoreceptor Contributes to the Natural Variation of Diapause Induction in Daphnia magna.
GP00001539
RHO
P08100
Physiology
unknown
Daphnia magna
(species)
Daphnia magna
(species)
G protein-coupled receptor rhodopsin
Daphnia magna
(species)
Published - Accepted by Curator
GAL1
Carbohydrate metabolism (galactose)
Cis-regulatory,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species)
Intergeneric or Higher
Candidate Gene
Hittinger CT; Carroll SB (2007)
Gene duplication and the adaptive evolution of a classic genetic switch.
GP00000385
GAL1
P09608
Physiology
Helical phasing of GAL4 elements in promoter region following duplication
Kluyveromyces lactis
(species)
Saccharomyces cerevisiae
baker's yeast - (species)
GAL1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
GAL1
Carbohydrate metabolism
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species) D
Interspecific
Candidate Gene
Roop JI; Chang KC; Brem RB (2016)
Polygenic evolution of a sugar specialization trade-off in yeast.
GP00001425
GAL1
P04385
Physiology
unknown
Saccharomyces bayanus
(species)
Saccharomyces cerevisiae
baker's yeast - (species) D
GAL1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
GAL10
Carbohydrate metabolism
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species) D
Interspecific
Candidate Gene
Roop JI; Chang KC; Brem RB (2016)
Polygenic evolution of a sugar specialization trade-off in yeast.
GP00001428
GAL10
P04397
Physiology
unknown
Saccharomyces bayanus
(species)
Saccharomyces cerevisiae
baker's yeast - (species) D
GAL10
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
GAL3
Carbohydrate metabolism
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species) D
Interspecific
Candidate Gene
Roop JI; Chang KC; Brem RB (2016)
Polygenic evolution of a sugar specialization trade-off in yeast.
GP00001426
GAL3
P13045
Physiology
unknown
Saccharomyces bayanus
(species)
Saccharomyces cerevisiae
baker's yeast - (species) D
GAL3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
GAL4
Carbohydrate metabolism
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species) D
Interspecific
Candidate Gene
Roop JI; Chang KC; Brem RB (2016)
Polygenic evolution of a sugar specialization trade-off in yeast.
GP00001427
GAL4
P04386
Physiology
unknown
Saccharomyces bayanus
(species)
Saccharomyces cerevisiae
baker's yeast - (species) D
GAL4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
gastrin
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001914
GAST
P01350
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
gastrin
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
GATA-binding protein 2 (GATA2)
Hematopoiesis (blood basophil count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001610
GATA2
P23769
Physiology
G>A at the associated SNP. Another variant (rs6782812) in a pleiotropic myeloid enhancer near GATA2 reduced enhancer activity by 69%
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GATA-binding protein 2 (GATA2)
Homo sapiens
human - (species)
Published - Accepted by Curator
GCLM
Recombination rate
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001664
GCLM
Q2T9Y6
Physiology
On chromosome 3. Associated SNP upstream of the gene
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
GCLM
Bos taurus
cattle - (species)
Published - Accepted by Curator
GDF9
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Silva BD; Castro EA; Souza CJ ; et al. (2011)
A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increas[...]
GP00000390
GDF9
O60383
Physiology
F345C
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
GDF9
Ovis aries
sheep - (species)
Published - Accepted by Curator
GDF9
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species)
Domesticated
Linkage Mapping
Nicol L; Bishop SC; Pong-Wong R ; et al. (2009)
Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility i[...]
GP00000391
GDF9
O60383
Physiology
g.41841117A>C c.1279A>C p.S427R
Ovis aries
sheep - (species)
Ovis aries
sheep - (species)
GDF9
Ovis aries
sheep - (species)
Published - Accepted by Curator
GDF9
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Våge DI; Husdal M; Kent MP ; et al. (2013)
A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter siz[...]
1 Additional References
GP00002186
GDF9
O60383
Physiology
g.41841285G>A c.1111G>A p.V371M
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
GDF9
Ovis aries
sheep - (species)
Published - Accepted by Curator
GDF9
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Linkage Mapping
Hanrahan JP; Gregan SM; Mulsant P ; et al. (2004)
Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both inc[...]
GP00002187
GDF9
O60383
Physiology
g.41841212C>T c.1184C>T p.S395F
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
GDF9
Ovis aries
sheep - (species)
Published - Accepted by Curator
GDF9
Fertility (increased ovulation rate)
Coding,
SNP
Ovis aries
sheep - (species) D
Domesticated
Candidate Gene
Souza CJ; McNeilly AS; Benavides MV ; et al. (2014)
Mutation in the protease cleavage site of GDF9 increases ovulation rate and litter size in heterozyg[...]
GP00002188
GDF9
O60383
Physiology
g.41841453C>T c.943C>T p.R315C
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
GDF9
Ovis aries
sheep - (species)
Published - Accepted by Curator
Ge-1
Pathogen resistance (sigma virus)
Coding,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Cao C; Magwire MM; Bayer F ; et al. (2016)
A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rh[...]
GP00001993
Ge-1
Q9VKK1
Physiology
78bp deletion ( 2L:11097925 ..11098002 in both Release 5 and Release 6 coordinates) in the fifth exon of Ge-1 which reduces the length of the serine-rich linker region by 26 amino acid residues
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Ge-1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
gfzf
Hybrid incompatibility (F1 male lethality)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Phadnis N; Baker EP; Cooper JC ; et al. (2015)
An essential cell cycle regulation gene causes hybrid inviability in Drosophila.
GP00000392
gfzf
Q6NP69
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
gfzf
Drosophila simulans
(species)
Published - Accepted by Curator
Ghd7
Flowering time
Inflorescence morphology
Unknown,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Xue W; Xing Y; Weng X ; et al. (2008)
Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice.
GP00000393
GHD7
E5RQA1
Physiology
Morphology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Ghd7
Oryza sativa
rice - (species)
Published - Accepted by Curator
GIGANTEA
Photoperiod response
Circadian rhythm
Coding,
SNP
Brassica rapa
field mustard - (species)
Domesticated
Linkage Mapping
Xie Q; Lou P; Hermand V ; et al. (2015)
Allelic polymorphism of GIGANTEA is responsible for naturally occurring variation in circadian perio[...]
GP00000396
GI
Q9SQI2
Physiology
Physiology
Ser264Ala
Brassica rapa
field mustard - (species)
Brassica rapa
field mustard - (species)
GIGANTEA
Brassica rapa
field mustard - (species)
Published - Accepted by Curator
GL7
Grain size
Grain quality
Gene Amplification,
Indel
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Wang Y; Xiong G; Hu J ; et al. (2015)
Copy number variation at the GL7 locus contributes to grain size diversity in rice.
GP00001541
LNG1
Q9LF24
Morphology
Physiology
tandem duplication of a 17.1 kb segment containing GL7. Both copies encode exactly the same polypeptide and exhibit similar transcript levels leading to upregulation
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
GL7
Oryza sativa
rice - (species)
Published - Accepted by Curator
GLC-1
Xenobiotic resistance (antihelmintics)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Ghosh R; Andersen EC; Shapiro JA ; et al. (2012)
Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.
GP00000400
glc-1
G5EBR3
Physiology
4aa deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
GLC-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance (malaria)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001)
Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]
GP00000401
G6PD
P11413
Physiology
Ser188Phe C>T
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-6-phosphate dehydrogenase (G6PD)
Homo sapiens
human - (species)
Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance (malaria)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Louicharoen C; Patin E; Paul R ; et al. (2009)
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.
GP00000402
G6PD
P11413
Physiology
Ser163Gly
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-6-phosphate dehydrogenase (G6PD)
Homo sapiens
human - (species)
Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance (malaria)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001)
Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]
GP00000403
G6PD
P11413
Physiology
Val68Met G>A at nucleotide position 376 in exon 5 - OMIM code +305900.0002
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-6-phosphate dehydrogenase (G6PD)
Homo sapiens
human - (species)
Published - Accepted by Curator
Glucose-dependent insulinotropic polypeptide
Glycemia
Adipolysis rate
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Chang CL; Cai JJ; Lo C ; et al. (2011)
Adaptive selection of an incretin gene in Eurasian populations.
GP00000404
GIP
P09681
Physiology
Physiology
Ser103Gly
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-dependent insulinotropic polypeptide
Homo sapiens
human - (species)
Published - Accepted by Curator
GLUD2 retrogene
Gene expression change (novel expression domain in testicles and brain)
Gene Amplification,
Complex Change
Hominidae
great apes - (family) D
Intergeneric or Higher
Candidate Gene
Burki F; Kaessmann H (2004)
Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.
1 Additional References
GP00000405
GLUD2
P49448
Physiology
Retroduplication; + E7K enhancing mitochondrial targeting
Mammalia
mammals - (class)
Hominidae
great apes - (family) D
GLUD2 retrogene
Hominidae
great apes - (family)
Published - Accepted by Curator
glutamate dehydrogenase (GDH)
Silk yield
Unknown,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xiang H; Liu X; Li M ; et al. (2018)
The evolutionary road from wild moth to domestic silkworm.
1 Additional References
GP00002406
bb8
Q9VCN3
Physiology
Increased expression in the domesticated strains
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
glutamate dehydrogenase (GDH)
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
glutamate synthase (GOGAT)
Silk yield
Unknown,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xiang H; Liu X; Li M ; et al. (2018)
The evolutionary road from wild moth to domestic silkworm.
1 Additional References
GP00002407
GS
M9NFH8
Physiology
Increased expression in the domesticated strains at the larval stage
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
glutamate synthase (GOGAT)
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; abamectin)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Dermauw W; Ilias A; Riga M ; et al. (2012)
The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: implications for acaricide[...]
GP00002601
GluClalpha
Q94900
Physiology
G326E inTu_GluCl3
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
glutamate-gated chloride channel (GluCl)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; nodulisporic acid)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Kane NS; Hirschberg B; Qian S ; et al. (2000)
Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasit[...]
GP00002602
GluClalpha
Q94900
Physiology
P299S
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
glutamate-gated chloride channel (GluCl)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; ivermectin)
Coding,
SNP
Cooperia oncophora
(species) D
Intraspecific
Candidate Gene
Njue AI; Hayashi J; Kinne L ; et al. (2004)
Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits [...]
GP00002603
GluClalpha
Q94900
Physiology
E114G V235A L256F in the GluCla3 ortholog and V60A R101Hin the GluClb ortholog.
Cooperia oncophora
(species)
Cooperia oncophora
(species) D
glutamate-gated chloride channel (GluCl)
Cooperia oncophora
(species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; ivermectin)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Kwon DH; Yoon KS; Clark JM ; et al. (2010)
A point mutation in a glutamate-gated chloride channel confers abamectin resistance in the two-spott[...]
1 Additional References
GP00002604
GluClalpha
Q94900
Physiology
G323D in the highly conserved TM2 region of Tu_GluCl
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
glutamate-gated chloride channel (GluCl)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; abamectin)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang X; Wang R; Yang Y ; et al. (2016)
A point mutation in the glutamate-gated chloride channel of Plutella xylostella is associated with r[...]
GP00002634
GluClalpha
Q94900
Physiology
A309V
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
glutamate-gated chloride channel (GluCl)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
glutamine synthetase 2 (GS)
Silk yield
Unknown,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xiang H; Liu X; Li M ; et al. (2018)
The evolutionary road from wild moth to domestic silkworm.
1 Additional References
GP00002405
Gs2
P20478
Physiology
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
glutamine synthetase 2 (GS)
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
glycerol-3-phosphate dehydrogenase (Gpdh)
Enzymatic activity
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Bewley Glenn C (1981
)
Genetic control of the developmental program of L‐glycerol‐3‐phosphate dehydrogenase isozymes in Dro[...]
GP00001992
Gpdh
P13706
Physiology
Exact causal mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
glycerol-3-phosphate dehydrogenase (Gpdh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
glycerol-3-phosphate dehydrogenase (Gpdh)
Enzymatic activity
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Wilanowski TM; Gibson JB; Symonds JE (1995)
Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila [...]
GP00001998
Gpdh
P13706
Physiology
insertion of a 8kb blood retrotransposon in the 3' region of the Gpdh gene 66bp downstream of the stop codon. This mutation induces a GPDH isozyme-GPDH-4-and alters the pattern of expression of the three normal isozymes-GPDH-1 to GPDH-3.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
glycerol-3-phosphate dehydrogenase (Gpdh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Glycophorin GYPA-GYPB-GYPE cluster
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
; Band G; Rockett KA ; et al. (2015)
A novel locus of resistance to severe malaria in a region of ancient balancing selection.
GP00000406
GYPA
P02724
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Glycophorin GYPA-GYPB-GYPE cluster
Homo sapiens
human - (species)
Published - Accepted by Curator
Glypican-3 (Gpc3)
Body size (weight)
Cis-regulatory,
Unknown
Mus musculus
house mouse - (species)
Domesticated
Linkage Mapping
Oliver F; Christians JK; Liu X ; et al. (2005)
Regulatory variation at glypican-3 underlies a major growth QTL in mice.
GP00000407
Gpc3
Q8CFZ4
Physiology
unknown; possible 3'UTR variation
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Glypican-3 (Gpc3)
Mus musculus
house mouse - (species)
Published - Accepted by Curator
GmHs1-1 (Glyma02g43700.1)
Seed hardness
Seed coat permeability
Coding,
SNP
Glycine max
soybean - (species) D
Domesticated
Linkage Mapping
Sun L; Miao Z; Cai C ; et al. (2015)
GmHs1-1, encoding a calcineurin-like protein, controls hard-seededness in soybean.
GP00001543
Hs1
I1JIK2
Physiology
Physiology
C>T p.Thr>Met predicted to affect the alpha-helix of the protein
Glycine soja
(species)
Glycine max
soybean - (species) D
GmHs1-1 (Glyma02g43700.1)
Glycine max
soybean - (species)
Published - Accepted by Curator
GNBP1
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sackton TB; Lazzaro BP; Clark AG (2010)
Genotype and gene expression associations with immune function in Drosophila.
GP00000408
GNBP1
Q9NHB0
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
GNBP1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GNBP2
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sackton TB; Lazzaro BP; Clark AG (2010)
Genotype and gene expression associations with immune function in Drosophila.
GP00000409
GNBP2
Q9VVR4
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
GNBP2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GPA1
Pheromone response
Cell elongation
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Yvert G; Brem RB; Whittle J ; et al. (2003)
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.
1 Additional References
GP00000410
GPA1
P08539
Physiology
Physiology
Ser469Ile
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
GPA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
GPR133
Body size (weight)
Cis-regulatory,
Unknown
Mus musculus
house mouse - (species)
Domesticated
Association Mapping
Chan YF; Jones FC; McConnell E ; et al. (2012)
Parallel selection mapping using artificially selected mice reveals body weight control loci.
GP00000411
ADGRD1
Q6QNK2
Physiology
unknown
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
GPR133
Mus musculus
house mouse - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
Insertion
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001669
GPRC6A
Q5T6X5
Physiology
insertion of KL (6 bp) resulting in sequence KGKKLY in the third intracellular loop (ICL3) with surface expression and function greatly reduced
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
Deletion
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001670
GPRC6A
Q5T6X5
Physiology
KGRKLP>KGRK-Y in the third intracellular loop (ICL3) with surface expression and function greatly reduced
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001671
GPRC6A
Q5T6X5
Physiology
KGRKLP>KGK--Y in the third intracellular loop (ICL3) responsible for the intracellular retention and lack of function N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001672
GPRC6A
Q5T6X5
Physiology
C>T (aa57) located in the first exon resulting in a premature Stop-codon and non-functional protein N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPX2
Xenobiotic resistance (citrinin)
Cis-regulatory,
Unknown
Saccharomyces paradoxus
(species) D
Interspecific
Association Mapping
Naranjo S; Smith JD; Artieri CG ; et al. (2015)
Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.
GP00001310
GPX2
P38143
Physiology
mutations within 1kb in promotor region
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces paradoxus
(species) D
GPX2
Saccharomyces paradoxus
(species)
Published - Accepted by Curator
Gr5a
Taste sensitivity (sugar; trehalose)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Ueno K; Ohta M; Morita H ; et al. (2001)
Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory rec[...]
2 Additional References
GP00001997
Gr5a
Q9W497
Physiology
Nucleotide change: A5681571G - Amino acid change: T218A
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Gr5a
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GRAMD3
Body fat distribution (visceral)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001557
GRAMD2B
Q96HH9
Physiology
A>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GRAMD3
Homo sapiens
human - (species)
Published - Accepted by Curator
Green-sensitive opsin (RH2)
Color vision (blue shift)
Coding,
SNP
Thunnus orientalis
Pacific bluefin tuna - (species) D
Intergeneric or Higher
Candidate Gene
Nakamura Y; Mori K; Saitoh K ; et al. (2013)
Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna[...]
GP00001469
opn1mw1
Q9W6A5
Physiology
p.E122Q (G>C) in four of five genes
Percomorphaceae
(no rank)
Thunnus orientalis
Pacific bluefin tuna - (species) D
Green-sensitive opsin (RH2)
Thunnus orientalis
Pacific bluefin tuna - (species)
Published - Accepted by Curator
Green-sensitive opsin (RH2)
Color vision
Gene Loss,
Deletion
N
Sinocyclocheilus anshuiensis
(species) D
Sinocyclocheilus grahami
(species) D
Sinocyclocheilus rhinocerous
(species) D
Interspecific
Candidate Gene
Yang J; Chen X; Bai J ; et al. (2016)
The Sinocyclocheilus cavefish genome provides insights into cave adaptation.
GP00002354
opn1mw1
Q9W6A5
Physiology
Rh2-1 coding sequence absent from the full genome sequence of the three Sinocyclocheilus species N
Danio rerio
zebrafish - (species)
Sinocyclocheilus anshuiensis
(species) D
Sinocyclocheilus grahami
(species) D
Sinocyclocheilus rhinocerous
(species) D
Green-sensitive opsin (RH2)
Sinocyclocheilus anshuiensis
(species)
Sinocyclocheilus grahami
(species)
Sinocyclocheilus rhinocerous
(species)
Published - Accepted by Curator
Green-sensitive opsin (RH2)
Color vision
Gene Loss,
Deletion
N
Sinocyclocheilus anshuiensis
(species) D
Interspecific
Candidate Gene
Yang J; Chen X; Bai J ; et al. (2016)
The Sinocyclocheilus cavefish genome provides insights into cave adaptation.
GP00002355
opn1mw4
Q9W6A6
Physiology
Rh2-4 coding sequence absent from the full genome sequence of S. anshuiensis but present in the genome of Sinocyclocheilus rhinocerous and S. grahami N
Sinocyclocheilus grahami
(species)
Sinocyclocheilus anshuiensis
(species) D
Green-sensitive opsin (RH2)
Sinocyclocheilus anshuiensis
(species)
Published - Accepted by Curator
Green-sensitive opsin (RH2)
Color vision
Gene Loss,
Deletion
N
Sinocyclocheilus anshuiensis
(species) D
Sinocyclocheilus grahami
(species) D
Sinocyclocheilus rhinocerous
(species) D
Interspecific
Candidate Gene
Yang J; Chen X; Bai J ; et al. (2016)
The Sinocyclocheilus cavefish genome provides insights into cave adaptation.
GP00002356
opn1mw2
Q8AYM8
Physiology
Rh2-2 coding sequence absent from the full genome sequence of the three Sinocyclocheilus species N
Danio rerio
zebrafish - (species)
Sinocyclocheilus anshuiensis
(species) D
Sinocyclocheilus grahami
(species) D
Sinocyclocheilus rhinocerous
(species) D
Green-sensitive opsin (RH2)
Sinocyclocheilus anshuiensis
(species)
Sinocyclocheilus grahami
(species)
Sinocyclocheilus rhinocerous
(species)
Published - Accepted by Curator
Growth Hormone Receptor
Milk yield
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Viitala S; Szyda J; Blott S ; et al. (2006)
The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...]
1 Additional References
GP00000416
Ghr
P16882
Physiology
Phe279Tyr
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
Growth Hormone Receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
GSDMB
Body fat distribution (subcutaneous)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001556
GSDMB
Q8TAX9
Physiology
T>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GSDMB
Homo sapiens
human - (species)
Published - Accepted by Curator
GSS (glutathione synthetase)
Xenobiotic resistance (arsenic)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
1 Additional References
GP00002115
Gss2
Q86B44
Physiology
tandem duplication creating the Gss1/Gss2 gene pair. Associated with increased expression of Gss1.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
GSS (glutathione synthetase)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GST
Xenobiotic resistance (pyrethroid)
Gene Amplification,
Insertion
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Vontas JG; Small GJ; Nikou DC ; et al. (2002)
Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved [...]
GP00002643
GstD1
P20432
Physiology
nlgst1-1 is overexpressed in resistant insects. Southern analysis of genomic DNA from the resistant and susceptible strains indicated that GST-based insecticide resistance may be associated with gene amplification in N. lugens.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
GST
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Anopheles funestus
African malaria mosquito - (species)
Intraspecific
Candidate Gene
Riveron JM; Yunta C; Ibrahim SS ; et al. (2014)
A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]
GP00002455
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species)
GSTe
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera litura
(species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002456
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera litura
(species)
Spodoptera litura
(species)
GSTe
Spodoptera litura
(species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera frugiperda
fall armyworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002457
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species)
GSTe
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera exigua
beet armyworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002458
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species)
GSTe
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera littoralis
African cotton leafworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002459
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera littoralis
African cotton leafworm - (species)
Spodoptera littoralis
African cotton leafworm - (species)
GSTe
Spodoptera littoralis
African cotton leafworm - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Anopheles funestus
African malaria mosquito - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002460
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species)
GSTe
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
GSTE1-E10 cluster
Xenobiotic resistance (drug)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Kislukhin G; King EG; Walters KN ; et al. (2013)
The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.
GP00000419
GstE1
Q7KK90
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
GSTE1-E10 cluster
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Cavia porcellus
domestic guinea pig - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000420
Gulo
P58710
Physiology
pseudogenization involving invalidating mutations at most exons N
Mammalia
mammals - (class)
Cavia porcellus
domestic guinea pig - (species)
Gulo
Cavia porcellus
domestic guinea pig - (species)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Myotis lucifugus
little brown bat - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000421
Gulo
P58710
Physiology
pseudogenization N
Mammalia
mammals - (class)
Myotis lucifugus
little brown bat - (species)
Gulo
Myotis lucifugus
little brown bat - (species)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Primates
(order)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000422
Gulo
P58710
Physiology
pseudogenization N
Mammalia
mammals - (class)
Primates
(order)
Gulo
Primates
(order)
Published - Accepted by Curator
Gulo
Vitamin-C synthesis (loss)
Coding,
Complex Change
N
Pteropus vampyrus
large flying fox - (species)
Intergeneric or Higher
Association Mapping
Hiller M; Schaar BT; Indjeian VB ; et al. (2012)
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among [...]
GP00000423
Gulo
P58710
Physiology
pseudogenization N
Mammalia
mammals - (class)
Pteropus vampyrus
large flying fox - (species)
Gulo
Pteropus vampyrus
large flying fox - (species)
Published - Accepted by Curator
GW7
Grain shape
Grain quality
Cis-regulatory,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Wang S; Li S; Liu Q ; et al. (2015)
The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and [...]
GP00001540
TON1A
Q9FQ25
Morphology
Physiology
18 SNPs and 9 indels observed in the promoter region and exon 1 and in particular an 11-bp deletion and 18-bp insertion near GTAC motifs which are normally binded by OsSPL16 repressor (reduced binding increasing transcription)
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
GW7
Oryza sativa
rice - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
SNP
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000426
ABCA2
A0A0S0G7V0
Physiology
Pro53* (161T>A) N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Deletion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Xu X; Yu L; Wu Y (2005)
Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]
2 Additional References
GP00000427
ABCA2
A0A0S0G7V0
Physiology
10kb deletion N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Yang Y; Chen H; Wu S ; et al. (2006)
Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]
1 Additional References
GP00000428
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Yang Y; Chen H; Wu S ; et al. (2006)
Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]
1 Additional References
GP00000429
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000430
ABCA2
A0A0S0G7V0
Physiology
Insertion of an incomplete RNA transposon (1498bp) N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000431
ABCA2
A0A0S0G7V0
Physiology
Insertion of a DNA transposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000432
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000433
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
HAC1 (=ATQ1)
Xenobiotic resistance (soil contamination; arsenate)
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sánchez-Bermejo E; Castrillo G; del Llano B ; et al. (2014)
Natural variation in arsenate tolerance identifies an arsenate reductase in Arabidopsis thaliana.
1 Additional References
GP00000434
HAC1
Q9C5X9
Physiology
Coding variation and differential gene expression in roots
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
HAC1 (=ATQ1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
HAC1 (=ATQ1)
Xenobiotic resistance (soil contamination; arsenate)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Chao DY; Chen Y; Chen J ; et al. (2014)
Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]
GP00000435
HAC1
Q9C5X9
Physiology
1bp deletion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
HAC1 (=ATQ1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
HAO1
Fertility (egg production)
Bird head morphology (male comb)
Cis-regulatory,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Linkage Mapping
Johnsson M; Gustafson I; Rubin CJ ; et al. (2012)
A sexual ornament in chickens is affected by pleiotropic alleles at HAO1 and BMP2, selected during d[...]
1 Additional References
GP00000437
HAO1
E1BRR7
Physiology
Morphology
unknown; but intergenic QTL peak with decomposed effects on expression of BMP2 and HAO1
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
HAO1
Gallus gallus
chicken - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (mean blood corpuscular hemoglobin)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001607
HBS1L
Q9Y450
Physiology
T>C at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (mean blood corpuscular hemoglobin)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001608
HBS1L
Q9Y450
Physiology
A>G at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (red blood cell count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001609
HBS1L
Q9Y450
Physiology
C>T at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (blood platelet count)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001614
HBS1L
Q9Y450
Physiology
T>C at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
Hd1
Flowering time
Coding,
Insertion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Doi K; Izawa T; Fuse T ; et al. (2004)
Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-[...]
GP00000439
HD1
Q9FDX8
Physiology
Retro-element-like inserted in exon 2 N
Oryza glaberrima
African rice - (species)
Oryza sativa
rice - (species) D
Hd1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Hd1
Flowering time
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Yano M; Katayose Y; Ashikari M ; et al. (2000)
Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Ara[...]
1 Additional References
GP00000441
HD1
Q9FDX8
Physiology
2bp deletion in the putative exon 2 N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Hd1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Hd1
Flowering time
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Takahashi Y; Teshima KM; Yokoi S ; et al. (2009)
Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]
GP00001722
HD1
Q9FDX8
Physiology
1bp deletion at position 606 ; presumptive protein truncated N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Hd1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Hd1
Flowering time
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Takahashi Y; Teshima KM; Yokoi S ; et al. (2009)
Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]
GP00001723
HD1
Q9FDX8
Physiology
1bp deletion at position 321 ; presumptive protein truncated N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Hd1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Hd1
Flowering time
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Takahashi Y; Teshima KM; Yokoi S ; et al. (2009)
Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]
GP00001724
HD1
Q9FDX8
Physiology
4bp deletion at position 1089 ; presumptive protein truncated N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Hd1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Hd1
Flowering time
Coding,
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Takahashi Y; Teshima KM; Yokoi S ; et al. (2009)
Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of fl[...]
GP00001725
HD1
Q9FDX8
Physiology
C to T – stop codon N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Hd1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Hd6a
Flowering time
Coding,
SNP
N
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Takahashi Y; Shomura A; Sasaki T ; et al. (2001)
Hd6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the alpha subunit [...]
GP00000442
HD6
Q9AR27
Physiology
K91*; AAG>TAG N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Hd6a
Oryza sativa
rice - (species)
Published - Accepted by Curator
HEADING DATE 1
Flowering time (latitudinal adaptation)
Cis-regulatory,
Insertion
N
Oryza sativa Japonica Group
Japanese rice - (no rank) D
Domesticated
Candidate Gene
Goretti D; Martignago D; Landini M ; et al. (2017)
Transcriptional and Post-transcriptional Mechanisms Limit Heading Date 1 (Hd1) Function to Adapt Ric[...]
GP00001674
HD1
Q9FDX8
Physiology
Hd1(EH) allele with a 4.4 kb mobile element inserted at position -166pb that suppressed gene transcription N
Oryza sativa
rice - (species)
Oryza sativa Japonica Group
Japanese rice - (no rank) D
HEADING DATE 1
Oryza sativa Japonica Group
Japanese rice - (no rank)
Published - Accepted by Curator
Heading Date 1 (HD1)
Flowering time
Coding,
Deletion
N
Sorghum virgatum
(species) D
Domesticated
Association Mapping
Liu H; Liu H; Zhou L ; et al. (2015)
Parallel Domestication of the Heading Date 1 Gene in Cereals.
GP00001408
CO
Q39057
Physiology
5bp deletion in the coding sequence leading to gene frameshift N
Sorghum bicolor
sorghum - (species)
Sorghum virgatum
(species) D
Heading Date 1 (HD1)
Sorghum virgatum
(species)
Published - Accepted by Curator
Heading Date 1 (HD1)
Flowering time
Coding,
Deletion
N
Sorghum
(genus) D
Interspecific
Association Mapping
Liu H; Liu H; Zhou L ; et al. (2015)
Parallel Domestication of the Heading Date 1 Gene in Cereals.
GP00001409
CO
Q39057
Physiology
80bp deletion in first exon leading to gene frameshift N
Sorghum
(genus)
Sorghum
(genus) D
Heading Date 1 (HD1)
Sorghum
(genus)
Published - Accepted by Curator
Heading Date 1 (HD1)
Flowering time
Coding,
SNP
N
Setaria italica
foxtail millet - (species) D
Domesticated
Association Mapping
Liu H; Liu H; Zhou L ; et al. (2015)
Parallel Domestication of the Heading Date 1 Gene in Cereals.
GP00001410
CO
Q39057
Physiology
splicing variant at position 787 GT>AT resulting in a splicing shift to position 754 introducing a deletion of 33 bp in the transcript and 11 aa in the protein N
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Heading Date 1 (HD1)
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
2 Mutations:
Coding
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Chao DY; Silva A; Baxter I ; et al. (2012)
Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]
GP00000443
HMA3
P0CW78
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase3 (HMA3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Chao DY; Silva A; Baxter I ; et al. (2012)
Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]
GP00000444
HMA3
P0CW78
Physiology
1-bp deletion resulting in a premature stop codon resulting in hypofunctional transporter. This is a high-frequency allele; suggesting the hyper-functional alleles are only selected in Cd-rich soils N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase3 (HMA3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Ueno D; Yamaji N; Kono I ; et al. (2010)
Gene limiting cadmium accumulation in rice.
GP00000445
HMA3
P0CW78
Physiology
H80R
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
heavy metal atpase3 (HMA3)
Oryza sativa
rice - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
Gene Amplification,
Complex Change
Noccaea caerulescens
(species)
Intraspecific
Candidate Gene
Ueno D; Milner MJ; Yamaji N ; et al. (2011)
Elevated expression of TcHMA3 plays a key role in the extreme Cd tolerance in a Cd-hyperaccumulating[...]
GP00000446
HMA3
P0CW78
Physiology
Copy number Variant
Noccaea caerulescens
(species)
Noccaea caerulescens
(species)
heavy metal atpase3 (HMA3)
Noccaea caerulescens
(species)
Published - Accepted by Curator
heavy metal atpase4 (HMA4)
Metal tolerance
Unknown,
Unknown
Arabidopsis halleri
(species) D
Interspecific
Linkage Mapping
Courbot M; Willems G; Motte P ; et al. (2007)
A major quantitative trait locus for cadmium tolerance in Arabidopsis halleri colocalizes with HMA4,[...]
GP00000447
HMA4
O64474
Physiology
unknown
Arabidopsis lyrata
(species)
Arabidopsis halleri
(species) D
heavy metal atpase4 (HMA4)
Arabidopsis halleri
(species)
Published - Accepted by Curator
heavy metal atpase4 (HMA4)
Metal tolerance
Gene Amplification,
Complex Change
Arabidopsis halleri
(species)
Interspecific
Linkage Mapping
Hanikenne M; Talke IN; Haydon MJ ; et al. (2008)
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4.
1 Additional References
GP00000448
HMA4
O64474
Physiology
Gene duplication
Arabidopsis thaliana
thale cress - (species)
Arabidopsis halleri
(species)
heavy metal atpase4 (HMA4)
Arabidopsis halleri
(species)
Published - Accepted by Curator
heavy metal atpase4 (HMA4)
Metal tolerance
Cis-regulatory,
Unknown
Arabidopsis halleri
(species)
Interspecific
Linkage Mapping
Hanikenne M; Talke IN; Haydon MJ ; et al. (2008)
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4.
1 Additional References
GP00000449
HMA4
O64474
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis halleri
(species)
heavy metal atpase4 (HMA4)
Arabidopsis halleri
(species)
Published - Accepted by Curator
heavy metal atpase5 (HMA5)
Metal tolerance
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kobayashi Y; Kuroda K; Kimura K ; et al. (2008)
Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]
GP00000450
HMA5
Q9SH30
Physiology
P626L
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase5 (HMA5)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
heavy metal atpase5 (HMA5)
Metal tolerance
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kobayashi Y; Kuroda K; Kimura K ; et al. (2008)
Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]
GP00000451
HMA5
Q9SH30
Physiology
N923T
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase5 (HMA5)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
hemoglobin; HBA
Hypoxia response
Coding,
SNP
Lama
(genus)
Interspecific
Candidate Gene
Kleinschmidt T; März J; Jürgens KD ; et al. (1986)
Interaction of allosteric effectors with alpha-globin chains and high altitude respiration of mammal[...]
GP00000454
HBA1
P69905
Physiology
Asp122His
Mammalia
mammals - (class)
Lama
(genus)
hemoglobin; HBA
Lama
(genus)
Published - Accepted by Curator
hemoglobin; HBA and HBB
Hypoxia response
Coding,
SNP
Crocodylus niloticus
Nile crocodile - (species)
Intergeneric or Higher
Candidate Gene
Komiyama NH; Miyazaki G; Tame J ; et al. (1995)
Transplanting a unique allosteric effect from crocodile into human haemoglobin.
GP00000455
HBA1
P69905
Physiology
No more than 12 amino acid substitutions required for providing crocodile-like properties in engineered human Hb - effect of single amino acid changes not tested
Homo sapiens
human - (species)
Crocodylus niloticus
Nile crocodile - (species)
hemoglobin; HBA and HBB
Crocodylus niloticus
Nile crocodile - (species)
Published - Accepted by Curator
hemoglobin; HBA-T1 and T2 paralogues
Hypoxia response
5 Mutations:
Coding
SNP
Peromyscus maniculatus
North American deer mouse - (species) D
Intraspecific
Candidate Gene
Storz JF; Sabatino SJ; Hoffmann FG ; et al. (2007)
The molecular basis of high-altitude adaptation in deer mice.
2 Additional References
GP00000456
HBA1
P69905
Physiology
5 mutations
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species) D
hemoglobin; HBA-T1 and T2 paralogues
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas cyanoptera
cinnamon teal - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000457
HBA1
P69905
Physiology
Asn9Ser
Anas cyanoptera
cinnamon teal - (species)
Anas cyanoptera
cinnamon teal - (species) D
hemoglobin; HBA2
Anas cyanoptera
cinnamon teal - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000458
HBA1
P69905
Physiology
Ala77Thr
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
hemoglobin; HBA2
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000459
HBAD
P02001
Physiology
Ser130Phe
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
hemoglobin; HBA2
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas puna
(species) D
Interspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000460
HBA1
P69905
Physiology
Ala77Thr
Anas versicolor
(species)
Anas puna
(species) D
hemoglobin; HBA2
Anas puna
(species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas puna
(species) D
Interspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000461
HBAD
P02001
Physiology
Val96Ala
Anas versicolor
(species)
Anas puna
(species) D
hemoglobin; HBA2
Anas puna
(species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anser indicus
bar-headed goose - (species) D
Interspecific
Candidate Gene
Jessen TH; Weber RE; Fermi G ; et al. (1991)
Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...]
2 Additional References
GP00000462
HBA1
P69905
Physiology
Pro119Ala
Anser anser
domestic goose - (species)
Anser indicus
bar-headed goose - (species) D
hemoglobin; HBA2
Anser indicus
bar-headed goose - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Lophonetta specularioides
crested duck - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000463
HBA1
P69905
Physiology
Ala5Thr
Lophonetta specularioides
crested duck - (species)
Lophonetta specularioides
crested duck - (species) D
hemoglobin; HBA2
Lophonetta specularioides
crested duck - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Merganetta armata
(species) D
Intraspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000464
HBA1
P69905
Physiology
Ala77Thr
Merganetta armata
(species)
Merganetta armata
(species) D
hemoglobin; HBA2
Merganetta armata
(species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
2 Mutations:
Coding
SNP
Chloephaga melanoptera
Andean goose - (species) D
Interspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000465
HBAD
P02001
Physiology
2 mutations
Neochen jubata
Orinoco goose - (species)
Chloephaga melanoptera
Andean goose - (species) D
hemoglobin; HBA2
Chloephaga melanoptera
Andean goose - (species)
Published - Accepted by Curator
hemoglobin; HBB
Pathogen resistance (Plasmodium; malaria parasite)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Jallow M; Teo YY; Small KS ; et al. (2009)
Genome-wide and fine-resolution association analysis of malaria in West Africa.
GP00000466
HBB
P68871
Physiology
Glu6Val
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
hemoglobin; HBB
Homo sapiens
human - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
2 Mutations:
Coding
SNP
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000467
HBB
P68871
Physiology
2 mutations
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
hemoglobin; HBB
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
2 Mutations:
Coding
SNP
Anas georgica
yellow-billed pintail - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000468
HBB
P68871
Physiology
2 mutations
Anas georgica
yellow-billed pintail - (species)
Anas georgica
yellow-billed pintail - (species) D
hemoglobin; HBB
Anas georgica
yellow-billed pintail - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
2 Mutations:
Coding
SNP
Anas puna
(species) D
Interspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
GP00000469
HBB
P68871
Physiology
2 mutations
Anas
ducks - (genus)
Anas puna
(species) D
hemoglobin; HBB
Anas puna
(species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
2 Mutations:
Coding
SNP
Lophonetta specularioides
crested duck - (species) D
Interspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
GP00000470
HBB
P68871
Physiology
2 mutations
Anatidae
waterfowl - (family)
Lophonetta specularioides
crested duck - (species) D
hemoglobin; HBB
Lophonetta specularioides
crested duck - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
Coding,
SNP
Anas puna
(species) D
Interspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000471
HBB
P68871
Physiology
Asp94Glu
Anas versicolor
(species)
Anas puna
(species) D
hemoglobin; HBB
Anas puna
(species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
Coding,
SNP
Lophonetta specularioides
crested duck - (species) D
Intraspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000472
HBB
P68871
Physiology
Asp94Glu
Lophonetta specularioides
crested duck - (species)
Lophonetta specularioides
crested duck - (species) D
hemoglobin; HBB
Lophonetta specularioides
crested duck - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
Coding,
SNP
Chloephaga melanoptera
Andean goose - (species) D
Interspecific
Candidate Gene
Jessen TH; Weber RE; Fermi G ; et al. (1991)
Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein en[...]
2 Additional References
GP00000473
HBB
P68871
Physiology
Leu55Ser
Neochen jubata
Orinoco goose - (species)
Chloephaga melanoptera
Andean goose - (species) D
hemoglobin; HBB
Chloephaga melanoptera
Andean goose - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
Coding,
SNP
Chloephaga melanoptera
Andean goose - (species) D
Interspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000474
HBB
P68871
Physiology
Ala86Ser
Neochen jubata
Orinoco goose - (species)
Chloephaga melanoptera
Andean goose - (species) D
hemoglobin; HBB
Chloephaga melanoptera
Andean goose - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
3 Mutations:
Coding
SNP
Chloephaga melanoptera
Andean goose - (species) D
Interspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000475
HBA1
P69905
Physiology
3 mutations
Neochen jubata
Orinoco goose - (species)
Chloephaga melanoptera
Andean goose - (species) D
hemoglobin; HBB
Chloephaga melanoptera
Andean goose - (species)
Published - Accepted by Curator
hemoglobin; HBB-T1 and T2 paralogues
Hypoxia response
4 Mutations:
Coding
SNP
Peromyscus maniculatus
North American deer mouse - (species) D
Intraspecific
Candidate Gene
Storz JF; Runck AM; Sabatino SJ ; et al. (2009)
Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer [...]
1 Additional References
GP00000476
HBB
P68871
Physiology
4 mutations
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species) D
hemoglobin; HBB-T1 and T2 paralogues
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
hemoglobin; HBB/HBD fusion gene
Temperature tolerance (cold)
3 Mutations:
Coding
SNP
Mammuthus primigenius
woolly mammoth - (species)
Intergeneric or Higher
Candidate Gene
Campbell KL; Roberts JE; Watson LN ; et al. (2010)
Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance[...]
GP00000477
HBB
P68871
Physiology
3 mutations
Elephantidae
elephants - (family)
Mammuthus primigenius
woolly mammoth - (species)
hemoglobin; HBB/HBD fusion gene
Mammuthus primigenius
woolly mammoth - (species)
Published - Accepted by Curator
high expression of osmotically responsive genes 2
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001435
SAL1
Q42546
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
high expression of osmotically responsive genes 2
Arabidopsis arenosa
(species)
Published - Accepted by Curator
HLA-DQA1
Histocompatibility
Cis-regulatory,
Unknown
Papio
baboons - (genus)
Intraspecific
Candidate Gene
Loisel DA; Rockman MV; Wray GA ; et al. (2006)
Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region.
GP00000478
HLA-DQA1
P01909
Physiology
Promoter variation
Papio
baboons - (genus)
Papio
baboons - (genus)
HLA-DQA1
Papio
baboons - (genus)
Published - Accepted by Curator
HLA-DRB1
Pathogen resistance (typhoid fever)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Dunstan SJ; Hue NT; Han B ; et al. (2014)
Variation at HLA-DRB1 is associated with resistance to enteric fever.
GP00000479
HLA-DRB1
Q30167
Physiology
uncharacterized
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HLA-DRB1
Homo sapiens
human - (species)
Published - Accepted by Curator
HM1 = HC toxin reductase (HCTR)
Pathogen resistance
Unknown,
Unknown
Zea mays
(species)
Domesticated
Candidate Gene
Multani DS; Meeley RB; Paterson AH ; et al. (1998)
Plant-pathogen microevolution: molecular basis for the origin of a fungal disease in maize.
GP00000480
hm1
O49163
Physiology
Not identified
Zea mays
(species)
Zea mays
(species)
HM1 = HC toxin reductase (HCTR)
Zea mays
(species)
Published - Accepted by Curator
HM1 = HC toxin reductase (HCTR) [possible pseudo-replicate from other Maize entry]
Pathogen resistance
Coding,
Insertion
N
Zea mays
(species) D
Domesticated
Linkage Mapping
Johal GS; Briggs SP (1992)
Reductase activity encoded by the HM1 disease resistance gene in maize.
1 Additional References
GP00000481
hm1
O49163
Physiology
256-bp transposable element insertion in exon 4 N
Zea mays
(species)
Zea mays
(species) D
HM1 = HC toxin reductase (HCTR) [possible pseudo-replicate from other Maize entry]
Zea mays
(species)
Published - Accepted by Curator
HM2 = HC toxin reductase (HCTR)
Pathogen resistance
Coding,
Deletion
N
Zea mays
(species) D
Domesticated
Candidate Gene
Chintamanani S; Multani DS; Ruess H ; et al. (2008)
Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred b[...]
GP00000482
hm2
B8QWA3
Physiology
deletion from exon 2 (nucleotide 420) to beyond the confines of the hm2 gene into an unknown genomic region. N
Zea mays
(species)
Zea mays
(species) D
HM2 = HC toxin reductase (HCTR)
Zea mays
(species)
Published - Accepted by Curator
HM2 = HC toxin reductase (HCTR)
Pathogen resistance
Coding,
Insertion
N
Zea mays
(species) D
Domesticated
Candidate Gene
Chintamanani S; Multani DS; Ruess H ; et al. (2008)
Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred b[...]
GP00000483
hm2
B8QWA3
Physiology
8-bp insertion in exon 1 that disrupt the reading frame and introduces a stop codon shortly after the beginning of the gene N
Zea mays
(species)
Zea mays
(species) D
HM2 = HC toxin reductase (HCTR)
Zea mays
(species)
Published - Accepted by Curator
HP1D2
Sex determination (sex ratio distortion)
Coding,
Deletion
N
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Helleu Q; Gérard PR; Dubruille R ; et al. (2016)
Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.
GP00001467
HP1D2
B4R6K0
Physiology
deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N
Drosophila simulans
(species)
Drosophila simulans
(species) D
HP1D2
Drosophila simulans
(species)
Published - Accepted by Curator
Hs1 = pro-1
Pathogen resistance (parasite, nematodes) (nematodes)
Gene Loss,
Complex Change
N
Beta vulgaris
(species)
Domesticated
Linkage Mapping
Cai D; Kleine M; Kifle S ; et al. (1997)
Positional cloning of a gene for nematode resistance in sugar beet.
GP00000490
HSPRO1
Q9LY61
Physiology
cDNA sequence lacking in genomic DNA N
Patellifolia
(genus)
Beta vulgaris
(species)
Hs1 = pro-1
Beta vulgaris
(species)
Published - Accepted by Curator
hsp70Ba
Temperature tolerance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Lerman DN; Michalak P; Helin AB ; et al. (2003)
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]
GP00002004
Hsp70Ba
Q8INI8
Physiology
A 1447 bp fragment corresponding to the 39 end of a jockey element is inserted 107 bps upstream of the hsp70Ba transcription start site in the T strain. The insertion intervenes between HSEs 2 and 3; displacing HSEs 3 and 4 as well as three GAGA elements.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
hsp70Ba
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
hsp70Ba
Temperature tolerance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Lerman DN; Michalak P; Helin AB ; et al. (2003)
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]
GP00002005
Hsp70Ba
Q8INI8
Physiology
Insertion of a 1222bp non-autonomous P-element at position -184 relative to the Hsp70Ba transcription start site. The P-element intervenes between the second and third heat shock response elements (HSEs).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
hsp70Ba
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
hsp70Ba
Temperature tolerance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Lerman DN; Michalak P; Helin AB ; et al. (2003)
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]
GP00002006
Hsp70Ba
Q8INI8
Physiology
A non-autonomous 1383bp P-element is inserted 97bp upstream of the Hsp70Ba transcription start site. The P-element intervenes between the second and third heat shock response elements (HSEs).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
hsp70Ba
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
HSP90
Developmental time
Unknown,
Insertion
Locusta migratoria
migratory locust - (species) D
Intraspecific
Candidate Gene
Chen B; Zhang B; Xu L ; et al. (2017)
Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation.
GP00002437
daf-21
Q18688
Physiology
an Lm1 SINE insertion in the third exon of the Hsp90 gene produces an alternative splicing form associated with faster development and higher developmental synchrony. Found by scanning Lm1 insertions in natural locust populations.
Locusta migratoria
migratory locust - (species)
Locusta migratoria
migratory locust - (species) D
HSP90
Locusta migratoria
migratory locust - (species)
Published - Accepted by Curator
HTR2C serotonin receptor
Immune response (complement activation)
Unknown,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Association Mapping
Biscarini F; Bovenhuis H; van Arendonk JA ; et al. (2010)
Across-line SNP association study of innate and adaptive immune response in laying hens.
GP00001595
HTR2C
F1N989
Physiology
unknown
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
HTR2C serotonin receptor
Gallus gallus
chicken - (species)
Published - Accepted by Curator
HTR3A serotonin receptor
Immune response (antibody titre)
Unknown,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Association Mapping
Biscarini F; Bovenhuis H; van Arendonk JA ; et al. (2010)
Across-line SNP association study of innate and adaptive immune response in laying hens.
GP00001596
HTR3A
A0A1D5P8L2
Physiology
unknown
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
HTR3A serotonin receptor
Gallus gallus
chicken - (species)
Published - Accepted by Curator
HUA2
Flowering time
Shoot morphology
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Wang Q; Sajja U; Rosloski S ; et al. (2007)
HUA2 caused natural variation in shoot morphology of A. thaliana.
GP00000491
HUA2
Q9XER9
Physiology
Morphology
K525E N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
HUA2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
HUA2
Flowering time
Coloration (temperature-dependent)
Coding,
Unknown
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ilk N; Ding J; Ihnatowicz A ; et al. (2015)
Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]
1 Additional References
GP00001230
HUA2
Q9XER9
Physiology
Morphology
Premature stop codon resulting in truncation of 290 C-terminal amino-acids (hua-2-5 Ler allele) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
HUA2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Human Leukocyte Antigen-B (HLA-B)
Pathogen resistance (HIV control)
5 Mutations:
Coding
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
; Pereyra F; Jia X ; et al. (2010)
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
GP00000492
HLA-B
P01889
Physiology
5 mutations
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Human Leukocyte Antigen-B (HLA-B)
Homo sapiens
human - (species)
Published - Accepted by Curator
HXT6/7
Low-glucose adaptation (experimental evolution)
Gene Amplification,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species)
Experimental Evolution
Association Mapping
Brown CJ; Todd KM; Rosenzweig RF (1998)
Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited [...]
4 Additional References
GP00000494
HXT6
P39003
Physiology
expansion by inequal recombination between HXT6 and HXT7 (99% nucleotide similarity) ; replicated in two independent studies and in multiple lines
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
HXT6/7
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Hybrid male rescue
Hybrid incompatibility (F1 male lethality)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Brideau NJ; Flores HA; Wang J ; et al. (2006)
Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.
GP00000495
Hmr
Q86CW5
Physiology
Rapid coding divergence
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Hybrid male rescue
Drosophila simulans
(species)
Published - Accepted by Curator
I cluster
Pathogen resistance
Unknown,
Unknown
Phaseolus vulgaris
(species) D
Domesticated
Linkage Mapping
Vallejos CE; Astua-Monge G; Jones V ; et al. (2006)
Genetic and molecular characterization of the I locus of Phaseolus vulgaris.
GP00000496
U5YMY7
Physiology
unknown; maps to a cluster of R-proteins
Phaseolus vulgaris
(species)
Phaseolus vulgaris
(species) D
I cluster
Phaseolus vulgaris
(species)
Published - Accepted by Curator
I Kappa B Kinase Interacting Protein (IKBIP)
Lifespan
Unknown,
Unknown
Nothobranchius furzeri
turquoise killifish - (species)
Intraspecific
Association Mapping
Reichwald K; Petzold A; Koch P ; et al. (2015)
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
GP00001678
IKBIP
Q70UQ0
Physiology
Under positive selection; down regulated in aging skin
Nothobranchius furzeri
turquoise killifish - (species)
Nothobranchius furzeri
turquoise killifish - (species)
I Kappa B Kinase Interacting Protein (IKBIP)
Nothobranchius furzeri
turquoise killifish - (species)
Published - Accepted by Curator
ICARUS1
Plant growth (leaf morphology ; temperature-dependent)
Hypersensitive to DNA damage
2 Mutations:
Coding
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Zhu W; Ausin I; Seleznev A ; et al. (2015)
Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at[...]
GP00002066
ICA1
A0A0F7PXK5
Physiology
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
ICARUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
IGK
Pathogen resistance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001382
IGKV1-5
P01602
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
IGK
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
IL4
Immune response
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Linkage Mapping
Rockman MV; Hahn MW; Soranzo N ; et al. (2003)
Positive selection on a human-specific transcription factor binding site regulating IL4 expression.
GP00000497
IL4
P05112
Physiology
_524T promoter single base-pair substitution affecting binding of the NFAT transcription factor
Homo sapiens
human - (species)
Homo sapiens
human - (species)
IL4
Homo sapiens
human - (species)
Published - Accepted by Curator
IME1
Sporulation efficiency
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Gerke J; Lorenz K; Cohen B (2009)
Genetic interactions between transcription factors cause natural variation in yeast.
GP00000498
IME1
P21190
Physiology
L325M and/or 1bp synonymous substitution
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
IME1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Immune deficiency
Pathogen resistance
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sceurman BK; Clark AG (2004)
Genetic basis of natural variation in D. melanogaster antibacterial immunity.
GP00000499
imd
Q9NHG0
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Immune deficiency
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Inhibitor of DNA binding 3 (id3)
Lifespan
Unknown,
Unknown
Nothobranchius furzeri
turquoise killifish - (species) D
Intraspecific
Association Mapping
Reichwald K; Petzold A; Koch P ; et al. (2015)
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
GP00001676
ID3
Q02535
Physiology
Signature of selection for id3. upregulated during aging in brain and skin. A radical substitution of a non-polar by a charged aa (A>Q) followed by a 2-aa deletion in the C-terminus
Nothobranchius furzeri
turquoise killifish - (species)
Nothobranchius furzeri
turquoise killifish - (species) D
Inhibitor of DNA binding 3 (id3)
Nothobranchius furzeri
turquoise killifish - (species)
Published - Accepted by Curator
Inhibitor of DNA binding 3 (id3)
Lifespan
Coding,
Deletion
Nothobranchius pienaari
(species) D
Interspecific
Association Mapping
Reichwald K; Petzold A; Koch P ; et al. (2015)
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
GP00001677
ID3
Q02535
Physiology
One evolutionarily conserved aa (E) is deleted in id3 C-terminus
Nothobranchius rachovii
bluefin notho - (species)
Nothobranchius pienaari
(species) D
Inhibitor of DNA binding 3 (id3)
Nothobranchius pienaari
(species)
Published - Accepted by Curator
InR
Fertility (ovariole number)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Green DA; Extavour CG (2012)
Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...]
1 Additional References
GP00000500
InR
P09208
Physiology
unknown; loss of function reduces ovariole number
Drosophila sechellia
(species)
Drosophila simulans
(species)
InR
Drosophila simulans
(species)
Published - Accepted by Curator
InR
Fertility
Developmental time
Body size
Stress response
Lifespan
Coding,
Indel
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Paaby AB; Bergland AO; Behrman EL ; et al. (2014)
A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-[...]
1 Additional References
GP00002663
InR
P09208
Morphology
Morphology; Physiology
Physiology
Physiology
Physiology
Deletion of 9 nucleotides in the first exon. The two alleles differ by presence/absence of the three amino acids QHH.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
InR
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Insulin-like growth factor 2 (IGF2)
Muscular mass
Fat deposition
Heart size
Cis-regulatory,
SNP
Sus scrofa domesticus
domestic pig - (subspecies)
Domesticated
Linkage Mapping
Van Laere AS; Nguyen M; Braunschweig M ; et al. (2003)
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.
GP00000502
Igf2
P09535
Morphology
Physiology
Morphology
1bp change
Sus scrofa
pig - (species)
Sus scrofa domesticus
domestic pig - (subspecies)
Insulin-like growth factor 2 (IGF2)
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
Interleukin 10 (IL10)
Immune response (antibody titre and complement activation)
Unknown,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Association Mapping
Biscarini F; Bovenhuis H; van Arendonk JA ; et al. (2010)
Across-line SNP association study of innate and adaptive immune response in laying hens.
GP00001597
IL10
Q6A2H4
Physiology
unknown
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
Interleukin 10 (IL10)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Interleukin 12B (IL12B)
Immune response (antibody titre)
Unknown,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Association Mapping
Biscarini F; Bovenhuis H; van Arendonk JA ; et al. (2010)
Across-line SNP association study of innate and adaptive immune response in laying hens.
GP00001594
IL-12B
Q6X0K9
Physiology
unknown
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
Interleukin 12B (IL12B)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Interleukin 17A (IL17A)
Immune response (antibody titre and complement activation)
Unknown,
Unknown
Gallus gallus
chicken - (species)
Domesticated
Association Mapping
Biscarini F; Bovenhuis H; van Arendonk JA ; et al. (2010)
Across-line SNP association study of innate and adaptive immune response in laying hens.
GP00001593
IL17A
B4ER12
Physiology
unknown
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
Interleukin 17A (IL17A)
Gallus gallus
chicken - (species)
Published - Accepted by Curator
interleukin-4
Immune response
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Interspecific
Candidate Gene
Rockman MV; Hahn MW; Soranzo N ; et al. (2003)
Positive selection on a human-specific transcription factor binding site regulating IL4 expression.
GP00000504
IL4R
P24394
Physiology
1bp substitution in promoter
Primates
(order)
Homo sapiens
human - (species)
interleukin-4
Homo sapiens
human - (species)
Published - Accepted by Curator
Ir75a
Olfaction
Coding,
SNP
Drosophila sechellia
(species) D
Interspecific
Candidate Gene
Prieto-Godino LL; Rytz R; Bargeton B ; et al. (2016)
Olfactory receptor pseudo-pseudogenes.
GP00001701
Ir75a
Q9VVL1
Physiology
T289S and/or Q536K and/or F538L - introduction of these three amino acid changes in the D. melanogaster protein is sufficient to confer response indistinguishable from the one of D. sechellia
Drosophila melanogaster
fruit fly - (species)
Drosophila sechellia
(species) D
Ir75a
Drosophila sechellia
(species)
Published - Accepted by Curator
Ir75b
Olfaction
Coding,
SNP
Drosophila sechellia
(species) D
Interspecific
Candidate Gene
Prieto-Godino LL; Rytz R; Cruchet S ; et al. (2017)
Evolution of Acid-Sensing Olfactory Circuits in Drosophilids.
GP00001702
Ir75b
B7Z069
Physiology
T523S in the LBD domain - caused by C1568G
Drosophila melanogaster
fruit fly - (species)
Drosophila sechellia
(species) D
Ir75b
Drosophila sechellia
(species)
Published - Accepted by Curator
IRA1
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00001709
IRA1
P18963
Physiology
Arg1583Lys (G>A at position 521875 according to Table 1) - AGR to AAR position 521875
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
IRA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
IRA2
Growth rate (environment-dependent)
Coding,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Smith EN; Kruglyak L (2008)
Gene-environment interaction in yeast gene expression.
GP00000505
IRA2
P19158
Physiology
unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
IRA2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Isocitrate dehydrogenase (NADP) (IDH)
Temperature tolerance (temperature range)
2 Mutations:
Coding
SNP
Mytilus trossulus
common blue mussel - (species)
Interspecific
Candidate Gene
Lockwood BL; Somero GN (2012)
Functional determinants of temperature adaptation in enzymes of cold- versus warm-adapted mussels (G[...]
GP00000506
I1VYX2
Physiology
2 mutations
Mytilus galloprovincialis
Mediterranean mussel - (species)
Mytilus trossulus
common blue mussel - (species)
Isocitrate dehydrogenase (NADP) (IDH)
Mytilus trossulus
common blue mussel - (species)
Published - Accepted by Curator
JAK2
Hematopoiesis (blood platelet count)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001613
JAK2
O60674
Physiology
G>A at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
JAK2
Homo sapiens
human - (species)
Published - Accepted by Curator
Jheh1-Jheh2-Jheh3 complex
Oxidative stress resistance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
González J; Macpherson JM; Petrov DA (2009)
A recent adaptive transposable element insertion near highly conserved developmental loci in Drosoph[...]
1 Additional References
GP00001782
JHEH
Q6U6J0
Physiology
insertion of a transposable element Bari-Jheh associated with downregulation of Juvenile hormone epoxy hydroxylase 2 (Jheh2) and Jheh3 in nonstress conditions and with upregulation of Jheh1 and Jheh2 and downregulation of Jheh3 under oxidative stress conditions
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Jheh1-Jheh2-Jheh3 complex
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
JMJD1C
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001606
JMJD1C
Q15652
Physiology
T>A at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
JMJD1C
Homo sapiens
human - (species)
Published - Accepted by Curator
JYalpha
Hybrid incompatibility (F2 male sterility)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Masly JP; Jones CD; Noor MA ; et al. (2006)
Gene transposition as a cause of hybrid sterility in Drosophila.
GP00000508
JYalpha
A8QI34
Physiology
Gene transposition
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
JYalpha
Drosophila simulans
(species)
Published - Accepted by Curator
K+ uptake permease 9
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001430
POT9
O49423
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
K+ uptake permease 9
Arabidopsis arenosa
(species)
Published - Accepted by Curator
KAI2 paralogs
Seed dormancy (strigolactone responsiveness)
Coding,
Unknown
Orobancheae
(tribe) D
Intergeneric or Higher
Candidate Gene
Conn CE; Bythell-Douglas R; Neumann D ; et al. (2015)
PLANT EVOLUTION. Convergent evolution of strigolactone perception enabled host detection in parasiti[...]
GP00000509
D14
Q10QA5
Physiology
Ligand-binding pocket tuning in duplicated gene
Orobanchaceae
(family)
Orobancheae
(tribe) D
KAI2 paralogs
Orobancheae
(tribe)
Published - Accepted by Curator
KCNH4 - uncertain
Freshwater adaptation
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Association Mapping
Jones FC; Grabherr MG; Chan YF ; et al. (2012)
The genomic basis of adaptive evolution in threespine sticklebacks.
GP00000510
KCNH4
Q9UQ05
Physiology
Large Inversion resulting in alternative transcripts
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
KCNH4 - uncertain
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
KCS18
Oil composition
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Jasinski S; Lécureuil A; Miquel M ; et al. (2012)
Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]
GP00000512
FAE1
Q38860
Physiology
L407V N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
KCS18
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001510
PF3D7_1343700
Q8IDQ2
Physiology
D353Y affecting the BTB/POZ domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001511
PF3D7_1343700
Q8IDQ2
Physiology
P441L affecting the BTB/POZ domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001512
PF3D7_1343700
Q8IDQ2
Physiology
F446I affecting the encoded propeller and BTB/POZ domains
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001513
PF3D7_1343700
Q8IDQ2
Physiology
G449A affecting the encoded propeller and BTB/POZ domains
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001514
PF3D7_1343700
Q8IDQ2
Physiology
N458Y affecting the encoded propeller and BTB/POZ domains
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001515
PF3D7_1343700
Q8IDQ2
Physiology
A481V affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001516
PF3D7_1343700
Q8IDQ2
Physiology
p.Tyr493His affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001517
PF3D7_1343700
Q8IDQ2
Physiology
N525D affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001518
PF3D7_1343700
Q8IDQ2
Physiology
N537I affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001519
PF3D7_1343700
Q8IDQ2
Physiology
p.Arg539Thr affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001520
PF3D7_1343700
Q8IDQ2
Physiology
p.Ile543Thr affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001521
PF3D7_1343700
Q8IDQ2
Physiology
p.Pro553Leu affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001522
PF3D7_1343700
Q8IDQ2
Physiology
R561H affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001523
PF3D7_1343700
Q8IDQ2
Physiology
V568G affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001524
PF3D7_1343700
Q8IDQ2
Physiology
P574L affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001525
PF3D7_1343700
Q8IDQ2
Physiology
p.Cys580Tyr affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001526
PF3D7_1343700
Q8IDQ2
Physiology
D584V affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001527
PF3D7_1343700
Q8IDQ2
Physiology
F673I affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001528
PF3D7_1343700
Q8IDQ2
Physiology
A675V affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001529
PF3D7_1343700
Q8IDQ2
Physiology
H719N affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13 (K13)
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Candidate Gene
Straimer J; Gnädig NF; Witkowski B ; et al. (2015)
Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clin[...]
GP00001388
PF13_0238
A0A077LQB4
Physiology
M476I
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13 (K13)
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kin of irre (kire)
Xenobiotic resistance (methylmercury ; development)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Montgomery SL; Vorojeikina D; Huang W ; et al. (2014)
Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myo[...]
GP00001398
kirre
Q9N9Y9
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
kin of irre (kire)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
L6
Pathogen resistance
Coding,
Insertion
N
Linum usitatissimum
flax - (species)
Intraspecific
Linkage Mapping
Lawrence GJ; Finnegan EJ; Ayliffe MA ; et al. (1995)
The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 an[...]
GP00000528
L6
Q40253
Physiology
Truncated protein due to insertion of a transposable element. Reversion to resistance among descendants of mutant X75 was associated with excision of the newly transposable element Ac. N
Linum usitatissimum
flax - (species)
Linum usitatissimum
flax - (species)
L6
Linum usitatissimum
flax - (species)
Published - Accepted by Curator
LACCASE 8
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001436
LAC8
Q9LFD2
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
LACCASE 8
Arabidopsis arenosa
(species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Linkage Mapping
Enattah NS; Sahi T; Savilahti E ; et al. (2002)
Identification of a variant associated with adult-type hypolactasia.
1 Additional References
GP00000529
LCT
P09848
Physiology
C-13910T
Homo sapiens
human - (species)
Homo sapiens
human - (species)
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe.
GP00000530
LCT
P09848
Physiology
C-13907G
Homo sapiens
human - (species)
Homo sapiens
human - (species)
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe.
GP00000531
LCT
P09848
Physiology
T-13915G
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe.
1 Additional References
GP00000532
LCT
P09848
Physiology
G14010C ; In Khoe Pastoralist group lactase persistence (LP)-regulatory region 2 SNPs with greatest frequencies 13910C>T and 14010G>C
Homo sapiens
human - (species)
Homo sapiens
human - (species)
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Jones BL; Raga TO; Liebert A ; et al. (2013)
Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.
1 Additional References
GP00001714
LCT
P09848
Physiology
T14009G (rs869051967) (ss 820486563)
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactate dehydrogenase-B (Ldh-B)
Stress response
Cis-regulatory,
Unknown
Fundulus heteroclitus
mummichog - (species)
Intraspecific
Linkage Mapping
Schulte PM; Glemet HC; Fiebig AA ; et al. (2000)
Adaptive variation in lactate dehydrogenase-B gene expression: role of a stress-responsive regulator[...]
GP00000533
ldhb
P20373
Physiology
unknown - candidate 1 bp change in southern populatin generates mammary tumor virus glucocorticoid responsive element
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species)
lactate dehydrogenase-B (Ldh-B)
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
lanosterol c14 demethylase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001951
CYP51A1
Q16850
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
lanosterol c14 demethylase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
lanosterol c14 demethylase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001952
CYP51A1
Q16850
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
lanosterol c14 demethylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
lanosterol synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001949
LSS
P48449
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
lanosterol synthase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
lanosterol synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001950
LSS
P48449
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
lanosterol synthase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002655
lectin-24A
Q9VQU4
Physiology
A cis-regulatory polymorphism in the gene Lectin-24A abolishes expression after infection and strongly reduces survival. 21bp indel (c.-171_-151del)
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002656
lectin-24A
Q9VQU4
Physiology
a 165bp deletion in the protein coding sequence that results in a shift in the reading frame and a premature stop codon (p.Phe217_Glu273del*) N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
SNP
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002657
Physiology
L81 >STOP - point mutation that introduces a premature stop codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
SNP
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002658
lectin-24A
Q9VQU4
Physiology
Q254 >STOP - point mutation that introduces a premature stop codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
SNP
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002659
lectin-24A
Q9VQU4
Physiology
F217 >STOP - point mutation that introduces a premature stop codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
LeSPL-CNR
Fruit ripening
Cis-regulatory,
Epigenetic Change
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Manning K; Tör M; Poole M ; et al. (2006)
A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibit[...]
GP00000539
101256245
Q0PY35
Physiology
Stable methylation in a 286bp region of the promoter
Solanum cheesmaniae
(species)
Solanum lycopersicum
tomato - (species) D
LeSPL-CNR
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
Lethal Hybrid rescue
Hybrid incompatibility (F1 male lethality)
Coding,
Insertion
Drosophila simulans
(species) D
Interspecific
Linkage Mapping
Brideau NJ; Flores HA; Wang J ; et al. (2006)
Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.
2 Additional References
GP00000540
Lhr
Q95RV3
Physiology
16a.a. insertion with effect in sensitive background only (Maheshwari and Barbash 2012)
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species) D
Lethal Hybrid rescue
Drosophila simulans
(species)
Published - Accepted by Curator
Lethal Hybrid rescue
Hybrid incompatibility (F1 male lethality)
Coding,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Maheshwari S; Barbash DA (2012)
An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is funct[...]
GP00000541
Lhr
Q95RV3
Physiology
Coding divergence in a conserved stretch of 10 C-terminal amino-acids
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Lethal Hybrid rescue
Drosophila simulans
(species)
Published - Accepted by Curator
LEU2
Xenobiotic resistance
Gene Loss,
Complex Change
N
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Perlstein EO; Ruderfer DM; Roberts DC ; et al. (2007)
Genetic basis of individual differences in the response to small-molecule drugs in yeast.
GP00000542
LEU2
P04173
Physiology
Deletion N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
LEU2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
LIMONENE-MYRCENE SYNTHASE (LMS)
Fragrance (floral terpenoid volatiles; D -limonene and beta-myrcene)
Coding,
SNP
N
Erythranthe cardinalis
(species) D
Interspecific
Linkage Mapping
Byers KJ; Vela JP; Peng F ; et al. (2014)
Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...]
GP00001761
LMS
W6A2K5
Physiology
G66T transversion mutation in exon 3 of McLMS (KM659024) that results in a nonsense mutation in the McLMS protein (G201X) N
Erythranthe lewisii
(species)
Erythranthe cardinalis
(species) D
LIMONENE-MYRCENE SYNTHASE (LMS)
Erythranthe cardinalis
(species)
Published - Accepted by Curator
Linamarase
Toxicity levels (cyanogenic glucoside)
Gene Loss,
Deletion
N
Trifolium repens
white clover - (species) D
Intraspecific
Linkage Mapping
Olsen KM; Hsu SC; Small LL (2008)
Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...]
1 Additional References
GP00000549
LI
P26205
Physiology
Gene deletion N
Trifolium repens
white clover - (species)
Trifolium repens
white clover - (species) D
Linamarase
Trifolium repens
white clover - (species)
Published - Accepted by Curator
lncRNA:Hsr omega
Temperature tolerance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
McKechnie SW; Halford MM; McColl G ; et al. (1998)
Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closel[...]
1 Additional References
GP00001999
Physiology
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
lncRNA:Hsr omega
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
LPAR1
Hematopoiesis (blood monocyte count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001612
LPAR1
Q92633
Physiology
A>G at the associated SNP. 2 variants located in an uncharacterized long noncoding RNA
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LPAR1
Homo sapiens
human - (species)
Published - Accepted by Curator
Lr21
Pathogen resistance
Coding,
Complex Change
Triticum aestivum
bread wheat - (species)
Domesticated
Linkage Mapping
Huang L; Brooks S; Li W ; et al. (2009)
Evolution of new disease specificity at a simple resistance locus in a crop-weed complex: reconstitu[...]
GP00000551
C5ID17
Physiology
Novel pathogen specificity resulting from chimerism of the parental alleles after intragenic recombination
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
Lr21
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
Lr67
Pathogen resistance (rust ; mildew)
Coding,
SNP
Triticum aestivum
bread wheat - (species) D
Domesticated
Linkage Mapping
Moore JW; Herrera-Foessel S; Lan C ; et al. (2015)
A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat.
GP00001535
A0A0S1LH45
Physiology
Gly144Arg (exon 2) leads to a protein incapable of glucose import; LR67res exerts a dominant-negative effect through heterodimerization with these functional transporters to reduce glucose uptake.; alterations in hexose transport in infected leaves may explain its ability to reduce the growth of multiple biotrophic pathogen species
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species) D
Lr67
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
Coding,
SNP
Pyrophorus plagiophthalamus
(species)
Intergeneric or Higher
Candidate Gene
Wood KV; Lam YA; Seliger HH ; et al. (1989)
Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors.
GP00000552
P08659
Physiology
several nucleotide substitutions leading to several amino acid changes -exact amino acid changes unknown
Photinus pyralis
common eastern firefly - (species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
Coding,
SNP
Pyrophorus plagiophthalamus
(species)
Intraspecific
Candidate Gene
Stolz U; Velez S; Wood KV ; et al. (2003)
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.
2 Additional References
GP00000553
P08659
Physiology
T739G and C740G in exon 4; leading to one amino acid change - colour difference between the yellow- and orange-emitting luciferases is due entirely to S247G
Pyrophorus plagiophthalamus
(species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
2 Mutations:
Coding
SNP
Pyrophorus plagiophthalamus
(species)
Intraspecific
Candidate Gene
Stolz U; Velez S; Wood KV ; et al. (2003)
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.
2 Additional References
GP00000554
P08659
Physiology
2 mutations
Pyrophorus plagiophthalamus
(species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
Coding,
SNP
Pyrophorus plagiophthalamus
(species)
Intraspecific
Candidate Gene
Stolz U; Velez S; Wood KV ; et al. (2003)
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.
2 Additional References
GP00001758
P08659
Physiology
exact causing amino acid change(s) unknown
Pyrophorus plagiophthalamus
(species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
LY86
Body fat distribution (visceral/subcutaneous ratio)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001562
LY86
O95711
Physiology
A>T in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LY86
Homo sapiens
human - (species)
Published - Accepted by Curator
LYPLAL1
Body fat distribution (visceral/subcutaneous ratio)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001561
LYPLAL1
Q5VWZ2
Physiology
T>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LYPLAL1
Homo sapiens
human - (species)
Published - Accepted by Curator
Lysine histidine transporter 1
Pathogen resistance
Coding,
Insertion
N
Zea mays
(species) D
Domesticated
Linkage Mapping
Zhao Y; Lu X; Liu C ; et al. (2012)
Identification and fine mapping of rhm1 locus for resistance to Southern corn leaf blight in maize.
GP00000555
LHT1
Q9FKS8
Physiology
354bp insertioin resulting in premature stop codon N
Zea mays
(species)
Zea mays
(species) D
Lysine histidine transporter 1
Zea mays
(species)
Published - Accepted by Curator
lysozyme
Digestion (anaerobic enzymatic activity)
5 Mutations:
Coding
SNP
Opisthocomus hoazin
(species) D
Intergeneric or Higher
Candidate Gene
Kornegay JR; Schilling JW; Wilson AC (1994)
Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.
GP00000556
LYZ1
P04421
Physiology
5 mutations
Aves
birds - (class)
Opisthocomus hoazin
(species) D
lysozyme
Opisthocomus hoazin
(species)
Published - Accepted by Curator
lysozyme
Digestion (anaerobic enzymatic activity)
5 Mutations:
Coding
SNP
Bos taurus
cattle - (species)
Intergeneric or Higher
Candidate Gene
Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2)
Adaptive evolution in the stomach lysozymes of foregut fermenters.
1 Additional References
GP00000557
LYZ1
P04421
Physiology
5 mutations
Mammalia
mammals - (class)
Bos taurus
cattle - (species)
lysozyme
Bos taurus
cattle - (species)
Published - Accepted by Curator
lysozyme
Digestion (anaerobic enzymatic activity)
5 Mutations:
Coding
SNP
Colobinae
(subfamily)
Intergeneric or Higher
Candidate Gene
Stewart CB; Schilling JW; Wilson AC (1987 Nov 26-Dec 2)
Adaptive evolution in the stomach lysozymes of foregut fermenters.
3 Additional References
GP00000558
LYZ1
P04421
Physiology
5 mutations
Primates
(order)
Colobinae
(subfamily)
lysozyme
Colobinae
(subfamily)
Published - Accepted by Curator
M
Pathogen resistance
Coding,
Deletion
Linum usitatissimum
flax - (species) D
Intraspecific
Linkage Mapping
Anderson PA; Lawrence GJ; Morrish BC ; et al. (1997)
Inactivation of the flax rust resistance gene M associated with loss of a repeated unit within the l[...]
GP00000559
P93244
Physiology
426bp deletion, probably by unequal recombination
Linum usitatissimum
flax - (species)
Linum usitatissimum
flax - (species) D
M
Linum usitatissimum
flax - (species)
Published - Accepted by Curator
Mac1
Virulence
Unknown,
Unknown
Cryptococcus neoformans
(species)
Intraspecific
Linkage Mapping
Lin X; Huang JC; Mitchell TG ; et al. (2006)
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha all[...]
GP00000560
CGB_D8050W
E6R4R6
Physiology
unknown
Cryptococcus neoformans
(species)
Cryptococcus neoformans
(species)
Mac1
Cryptococcus neoformans
(species)
Published - Accepted by Curator
MADS AFFECTING FLOWERING 2 (MAF2)
Flowering time
Cis-regulatory,
Insertion
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Rosloski SM; Jali SS; Balasubramanian S ; et al. (2010)
Natural diversity in flowering responses of Arabidopsis thaliana caused by variation in a tandem gen[...]
GP00000561
MAF2
Q84J38
Physiology
Insertion alleles - several
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
MADS AFFECTING FLOWERING 2 (MAF2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MAM1
Glucosinolate content
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kroymann J; Textor S; Tokuhisa JG ; et al. (2001)
A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chai[...]
3 Additional References
GP00000562
MAM1
Q9FG67
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
MAM1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MAM3
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001303
PMA1
P05030
Physiology
C>G (Gly > Arg) @ position 250
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MAM3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MAM3
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001304
PMA1
P05030
Physiology
C>T (Val > Ile) @ position 1120
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MAM3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MAM3
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001305
PMA1
P05030
Physiology
C>T (Ser > Asn) @ position 806
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MAM3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MAP4K4
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Unknown,
Unknown
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Guo Z; Kang S; Chen D ; et al. (2015)
MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacil[...]
GP00001673
MAP4K4
O95819
Physiology
MAP4K4 constitutively up-regulated leading to up-regulated PxABCC1 and down-regulated PxABCC2 and PxABCC3 and reduction of membrane-bound ALP (mALP) expression responsible for reduced Cry1Ac toxin binding to midgut proteins
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
MAP4K4
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
MARVELD3
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Timmann C; Thye T; Vens M ; et al. (2012)
Genome-wide association study indicates two novel resistance loci for severe malaria.
GP00000564
MARVELD3
Q96A59
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MARVELD3
Homo sapiens
human - (species)
Published - Accepted by Curator
MATE1/AltSB/SbMATE
Metal tolerance
Cis-regulatory,
Unknown
Sorghum bicolor
sorghum - (species)
Domesticated
Linkage Mapping
Magalhaes JV; Liu J; Guimarães CT ; et al. (2007)
A gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sor[...]
GP00000565
Physiology
unknown
Sorghum bicolor
sorghum - (species)
Sorghum bicolor
sorghum - (species)
MATE1/AltSB/SbMATE
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
MATE1/ZmMATE1
Metal tolerance
Unknown,
Unknown
Zea mays
(species)
Domesticated
Candidate Gene
Maron LG; Piñeros MA; Guimarães CT ; et al. (2010)
Two functionally distinct members of the MATE (multi-drug and toxic compound extrusion) family of tr[...]
GP00000566
Physiology
unknown
Zea mays
(species)
Zea mays
(species)
MATE1/ZmMATE1
Zea mays
(species)
Published - Accepted by Curator
MC4R
Sexual maturation (onset)
Gene Amplification,
Complex Change
Xiphophorus maculatus
southern platyfish - (species)
Intraspecific
Linkage Mapping
Lampert KP; Schmidt C; Fischer P ; et al. (2010)
Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorph[...]
GP00000638
mc4r
B0V1P1
Physiology
unknown in the species used in crosses but a strong coreelation of gene copy number is found with the phenotype in two closely related species
Xiphophorus maculatus
southern platyfish - (species)
Xiphophorus maculatus
southern platyfish - (species)
MC4R
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
MCO
Metal tolerance (copper)
Gene Amplification,
Insertion
Erythranthe guttata
spotted monkey flower - (species) D
Intraspecific
Linkage Mapping
Wright KM; Lloyd D; Lowry DB ; et al. (2013)
Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus.
1 Additional References
GP00001814
LPR2
Q949X9
Physiology
several recent tandem duplications of this gene are responsible for the 12x increase in expression observed in copper tolerant lines - 6X fold enrichment of aligned reads at MCO
Erythranthe guttata
spotted monkey flower - (species)
Erythranthe guttata
spotted monkey flower - (species) D
MCO
Erythranthe guttata
spotted monkey flower - (species)
Published - Accepted by Curator
MDR1
Xenobiotic resistance
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Kimchi-Sarfaty C; Oh JM; Kim IW ; et al. (2007)
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
GP00001858
ABCB1
P08183
Physiology
C3435T - synonymous mutation Ile - The SNP at position 26/3435 that changes the codon from ATC to ATT (Ile) reduces the codon usage from 47% to 35% (RSCU values change from 20.9 to 15.8). Leads to similar mRNA and protein levels but altered conformation of the protein.
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MDR1
Homo sapiens
human - (species)
Published - Accepted by Curator
MDS3
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Anderson JB; Funt J; Thompson DA ; et al. (2010)
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...]
1 Additional References
GP00000641
MDS3
P53094
Physiology
Phe - Val substitution
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MDS3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MEP2
Salt tolerance (experimental evolution; low ammonium)
Other,
Complex Change
Saccharomyces uvarum
(species)
Experimental Evolution
Association Mapping
Dunn B; Paulish T; Stanbery A ; et al. (2013)
Recurrent rearrangement during adaptive evolution in an interspecific yeast hybrid suggests a model [...]
GP00000651
MEP2
P41948
Physiology
Chimeric gene in diploid hybrids formed by recombination between the parental alleles
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces uvarum
(species)
MEP2
Saccharomyces uvarum
(species)
Published - Accepted by Curator
metal tolerance protein1
Metal tolerance
Gene Amplification,
Complex Change
Arabidopsis halleri
(species) D
Interspecific
Linkage Mapping
Dräger DB; Desbrosses-Fonrouge AG; Krach C ; et al. (2004)
Two genes encoding Arabidopsis halleri MTP1 metal transport proteins co-segregate with zinc toleranc[...]
1 Additional References
GP00000652
MTP1
Q9ZT63
Physiology
Copy number Variant
Arabidopsis lyrata
(species)
Arabidopsis halleri
(species) D
metal tolerance protein1
Arabidopsis halleri
(species)
Published - Accepted by Curator
metallothionein (Mtn)
Metal tolerance
Gene Amplification,
Complex Change
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Otto E; Young JE; Maroni G (1986)
Structure and expression of a tandem duplication of the Drosophila metallothionein gene.
1 Additional References
GP00000653
MtnA
P04357
Physiology
Gene duplication
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
metallothionein (Mtn)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
metallothionein (MtnA)
Oxidative stress resistance
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Catalán A; Glaser-Schmitt A; Argyridou E ; et al. (2016)
An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variatio[...]
GP00002018
MtnA
P04357
Physiology
49bp deletion in the MtnA 3'UTR
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
metallothionein (MtnA)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
metallothionein CUP1
Metal tolerance (copper)
Gene Amplification,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001289
CUP1-1
P0CX80
Physiology
Gene duplication
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
metallothionein CUP1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MGAM
Starch processing
Cis-regulatory,
Unknown
Canis lupus familiaris
dog - (subspecies)
Domesticated
Association Mapping
Axelsson E; Ratnakumar A; Arendt ML ; et al. (2013)
The genomic signature of dog domestication reveals adaptation to a starch-rich diet.
GP00000654
MGAM
O43451
Physiology
unknown
Canis lupus
gray wolf - (species)
Canis lupus familiaris
dog - (subspecies)
MGAM
Canis lupus familiaris
dog - (subspecies)
Published - Accepted by Curator
Mi1.2
Pathogen resistance (parasite)
Unknown,
Unknown
Solanum lycopersicum
tomato - (species)
Intraspecific
Linkage Mapping
Rossi M; Goggin FL; Milligan SB ; et al. (1998)
The nematode resistance gene Mi of tomato confers resistance against the potato aphid.
2 Additional References
GP00000655
Mi-1.2
O81137
Physiology
Not identified
Solanum peruvianum
(species)
Solanum lycopersicum
tomato - (species)
Mi1.2
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance (hepaciviruses)
Coding,
SNP
Papio anubis
olive baboon - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
GP00001452
MAVS
Q7Z434
Physiology
Cys508Arg disrupting the protease cleavage site
Miopithecus talapoin
talapoin - (species)
Papio anubis
olive baboon - (species) D
Mitochondrial antiviral signaling (MAVS)
Papio anubis
olive baboon - (species)
Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance (hepaciviruses)
Coding,
SNP
Macaca mulatta
Rhesus monkey - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
GP00001453
MAVS
Q7Z434
Physiology
Val506Gly resistant to cleavage
Miopithecus talapoin
talapoin - (species)
Macaca mulatta
Rhesus monkey - (species) D
Mitochondrial antiviral signaling (MAVS)
Macaca mulatta
Rhesus monkey - (species)
Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance (hepaciviruses)
Coding,
SNP
Ateles geoffroyi
black-handed spider monkey - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
GP00001454
MAVS
Q7Z434
Physiology
Val506Ala resistant to cleavage
Lagothrix lagotricha
brown woolly monkey - (species)
Ateles geoffroyi
black-handed spider monkey - (species) D
Mitochondrial antiviral signaling (MAVS)
Ateles geoffroyi
black-handed spider monkey - (species)
Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance (hepaciviruses)
Coding,
SNP
Plecturocebus moloch
red-bellied titi - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
GP00001455
MAVS
Q7Z434
Physiology
Val506Ala resistant to cleavage
Lagothrix lagotricha
brown woolly monkey - (species)
Plecturocebus moloch
red-bellied titi - (species) D
Mitochondrial antiviral signaling (MAVS)
Plecturocebus moloch
red-bellied titi - (species)
Published - Accepted by Curator
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance (hepaciviruses)
Coding,
SNP
Allenopithecus nigroviridis
Allen's swamp monkey - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
GP00001456
MAVS
Q7Z434
Physiology
Val506Met less susceptible to cleavage
Erythrocebus patas
red guenon - (species)
Allenopithecus nigroviridis
Allen's swamp monkey - (species) D
Mitochondrial antiviral signaling (MAVS)
Allenopithecus nigroviridis
Allen's swamp monkey - (species)
Published - Accepted by Curator
mitochondrial tyrosine tRNA
Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013)
An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...]
1 Additional References
GP00001971
Physiology
C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)
Drosophila simulans
(species)
Drosophila simulans
(species) D
mitochondrial tyrosine tRNA
Drosophila simulans
(species)
Published - Accepted by Curator
MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)
Ozone sensitivity (stomata opening and stomatal CO2-sensitivity)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Jakobson L; Vaahtera L; Tõldsepp K ; et al. (2016)
Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO[...]
GP00001383
MPK12
Q8GYQ5
Physiology
G53R
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MKT1
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Anderson JB; Funt J; Thompson DA ; et al. (2010)
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...]
1 Additional References
GP00000662
MKT1
P40850
Physiology
D30G (reversion; functionally verified); evolved independently in 3 lines
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MKT1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MKT1
Temperature tolerance
Virulence
Sporulation efficiency
Sporulation efficiency
Xenobiotic resistance (alcohol; ethanol)
Xenobiotic resistance (genotoxic DNA-damage agent)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
5 Additional References
GP00000666
MKT1
P40850
Physiology
Physiology
Physiology
Physiology
Physiology
Physiology
G30D (functionally verified); or haplotype including G30D (functionally verified)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
MKT1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Mla (=Sr33/AetRGA1e)
Pathogen resistance
Coding,
Unknown
Aegilops tauschii
(species)
Domesticated
Linkage Mapping
Periyannan S; Moore J; Ayliffe M ; et al. (2013)
The gene Sr33, an ortholog of barley Mla genes, encodes resistance to wheat stem rust race Ug99.
GP00000667
Mla1
Q7EXP5
Physiology
Unknown
Triticum aestivum
bread wheat - (species)
Aegilops tauschii
(species)
Mla (=Sr33/AetRGA1e)
Aegilops tauschii
(species)
Published - Accepted by Curator
Mla1
Pathogen resistance
Coding,
SNP
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Mahadevappa M; Descenzo RA; Wise RP (1994)
Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...]
3 Additional References
GP00000668
Mla1
Q7EXP5
Physiology
Coding variation in the LRR domain - exact amino acid change unknown
Hordeum vulgare
(species)
Hordeum vulgare
(species)
Mla1
Hordeum vulgare
(species)
Published - Accepted by Curator
Mla1
Pathogen resistance
Coding,
Unknown
Triticum monococcum
(species)
Domesticated
Candidate Gene
Halterman D; Zhou F; Wei F ; et al. (2001)
The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria g[...]
1 Additional References
GP00000669
Mla1
Q7EXP5
Physiology
Coding variation in the LRR domain
Triticum monococcum
(species)
Triticum monococcum
(species)
Mla1
Triticum monococcum
(species)
Published - Accepted by Curator
Mla13
Pathogen resistance
Coding,
SNP
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Mahadevappa M; Descenzo RA; Wise RP (1994)
Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...]
2 Additional References
GP00000670
Mla1
Q7EXP5
Physiology
Coding variation in the LRR domain - exact amino acid change unknown
Hordeum vulgare
(species)
Hordeum vulgare
(species)
Mla13
Hordeum vulgare
(species)
Published - Accepted by Curator
Mla6
Pathogen resistance
Coding,
SNP
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Mahadevappa M; Descenzo RA; Wise RP (1994)
Recombination of alleles conferring specific resistance to powdery mildew at the Mla locus in barley[...]
2 Additional References
GP00000671
Mla1
Q7EXP5
Physiology
Coding variation in the LRR domain - exact amino acid change(s) unknown
Hordeum vulgare
(species)
Hordeum vulgare
(species)
Mla6
Hordeum vulgare
(species)
Published - Accepted by Curator
MLO
Pathogen resistance
Gene Amplification,
Insertion
Hordeum vulgare
(species) D
Domesticated
Linkage Mapping
Piffanelli P; Ramsay L; Waugh R ; et al. (2004)
A barley cultivation-associated polymorphism conveys resistance to powdery mildew.
GP00000672
MLO
P93766
Physiology
Tandem array duplication including promoter and partial CDS; resulting in loss-of-function by transcriptional interference
Hordeum vulgare
(species)
Hordeum vulgare
(species) D
MLO
Hordeum vulgare
(species)
Published - Accepted by Curator
MLO1
Pathogen resistance
Coding,
SNP
N
Pisum sativum
pea - (species)
Domesticated
Linkage Mapping
Pavan S; Schiavulli A; Appiano M ; et al. (2011)
Pea powdery mildew er1 resistance is associated to loss-of-function mutations at a MLO homologous lo[...]
GP00000673
MLO
P93766
Physiology
1bp substitution resulting in premature stop codon N
Pisum sativum
pea - (species)
Pisum sativum
pea - (species)
MLO1
Pisum sativum
pea - (species)
Published - Accepted by Curator
MLO1
Pathogen resistance
Coding,
Deletion
N
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Bai Y; Pavan S; Zheng Z ; et al. (2008)
Naturally occurring broad-spectrum powdery mildew resistance in a Central American tomato accession [...]
GP00000674
MLO
P93766
Physiology
19bp deletion resulting in frameshift N
Solanum lycopersicum
tomato - (species)
Solanum lycopersicum
tomato - (species) D
MLO1
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
MNN4
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00001711
MNN4
P36044
Physiology
Lys924Glu (A>G at position 64698 according to Table 1) - AAR to GAR position 64698
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MNN4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MNR2
Bird head comb
Fertility (sperm motility)
Gene Amplification,
Inversion
Gallus gallus
chicken - (species) D
Domesticated
Linkage Mapping
Imsland F; Feng C; Boije H ; et al. (2012)
The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb [...]
GP00000675
MNR2
Q9YHY8
Morphology
Physiology
7.4Mb inversion (and secondary structural re-arrangement in some individuals)
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
MNR2
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Molybdenum transporter1 (MOT1)
Metal tolerance
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Baxter I; Muthukumar B; Park HC ; et al. (2008)
Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is co[...]
1 Additional References
GP00000676
MOT1
Q9SL95
Physiology
53bp deletion in promoter
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Molybdenum transporter1 (MOT1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Molybdenum transporter1 (MOT1)
Metal tolerance
Gene Amplification,
Insertion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Association Mapping
Forsberg SK; Andreatta ME; Huang XY ; et al. (2015)
The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentratio[...]
GP00000677
MOT1
Q9SL95
Physiology
330bp duplication followed by minor indels
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Molybdenum transporter1 (MOT1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Molybdenum transporter1 (MOT1)
Metal tolerance
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Poormohammad Kiani S; Trontin C; Andreatta M ; et al. (2012)
Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.
GP00001270
MOT1
Q9SL95
Physiology
D104Y
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Molybdenum transporter1 (MOT1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MPK12
Water absorption (water use efficiency)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Des Marais DL; Auchincloss LC; Sukamtoh E ; et al. (2014)
Variation in MPK12 affects water use efficiency in Arabidopsis and reveals a pleiotropic link betwee[...]
GP00001283
MPK12
Q8GYQ5
Physiology
GGT to CGT @position 53
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
MPK12
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MRC2
Muscular mass
Tail shape (crooked ; defect)
Coding,
Deletion
N
Bos taurus
cattle - (species) D
Domesticated
Association Mapping
Fasquelle C; Sartelet A; Li W ; et al. (2009)
Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Croo[...]
2 Additional References
GP00002264
MRC2
Q9UBG0
Physiology
Morphology
c.2904-2905delAG p.Gly934X N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
MRC2
Bos taurus
cattle - (species)
Published - Accepted by Curator
MRC2
Muscular mass
Tail shape (crooked ; defect)
Coding,
SNP
Bos taurus
cattle - (species) D
Domesticated
Association Mapping
Fasquelle C; Sartelet A; Li W ; et al. (2009)
Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Croo[...]
2 Additional References
GP00002265
MRC2
Q9UBG0
Physiology
Morphology
c.1906T>G p.C636G
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
MRC2
Bos taurus
cattle - (species)
Published - Accepted by Curator
MRS1
F2 lethality
3 Mutations:
Coding
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Interspecific
Linkage Mapping
Chou JY; Hung YS; Lin KH ; et al. (2010)
Multiple molecular mechanisms cause reproductive isolation between three yeast species.
GP00000678
MRS1
P07266
Physiology
3 mutations
Saccharomyces paradoxus
(species)
Saccharomyces bayanus
(species)
Saccharomyces kudriavzevii
(species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MRS1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MSH4
Recombination rate (female)
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001665
MSH4
E1BK76
Physiology
On chromosome 3. Associated SNP located in the intron of the gene
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
MSH4
Bos taurus
cattle - (species)
Published - Accepted by Curator
MTH1
Low-glucose adaptation (experimental evolution)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00000679
CUP1-1
P0CX80
Physiology
1bp substitution resulting in premature stop codon N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MTH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
MTH1
Low-glucose adaptation (experimental evolution)
Coding,
Insertion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gresham D; Desai MM; Tucker CM ; et al. (2008)
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]
GP00000680
CUP1-1
P0CX80
Physiology
Ty retrotranposition resulting in a coding frameshift N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MTH1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Domesticated
Linkage Mapping
Macquet A; Ralet MC; Loudet O ; et al. (2007)
A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...]
GP00000681
BGAL6
Q9FFN4
Physiology
44bp deletion in exon 15; from Leu-662 onwards. This deletion causes a frame-shift mutation changing the next 23 amino acids followed by the introduction of a stop codon. N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001274
BGAL6
Q9FFN4
Physiology
C->T @position 2223 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001275
BGAL6
Q9FFN4
Physiology
G->C @position 2240 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001276
BGAL6
Q9FFN4
Physiology
G->T @position 3425 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001277
BGAL6
Q9FFN4
Physiology
TACA insertion @position 4906 causing frame shift + Stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Mucin gene family
Salt tolerance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001378
MUC1
P15941
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Mucin gene family
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
MUK1
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00001713
MUK1
Q02866
Physiology
Ser441STP(C>A at position 422266 according to Table 1) - TCR to TAR position 422266
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
MUK1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Multidrug resistance protein 1 (pvmdr1)
Xenobiotic resistance (mefloquine)
Gene Amplification,
Insertion
Plasmodium vivax
malaria parasite P. vivax - (species) D
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001482
B7STB0
Physiology
37 kb duplication on chromosome 10 that includes pvmdr1
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species) D
Multidrug resistance protein 1 (pvmdr1)
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
multidrug resistance protein 2
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001532
PF3D7_1447900
Q8IKZ6
Physiology
p.Thr484Ile
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
multidrug resistance protein 2
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)
Glycogen content (muscles)
Coding,
SNP
Sus scrofa domesticus
domestic pig - (subspecies) D
Domesticated
Linkage Mapping
Milan D; Jeon JT; Looft C ; et al. (2000)
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle.
GP00000682
Prkag3
Q8BGM7
Physiology
R200Q in CBS1; which is the most conserved region among AMPK g chain isoforms; and R200 is conserved in mammalian and Drosophila AMPK g isoforms
Sus scrofa
pig - (species)
Sus scrofa domesticus
domestic pig - (subspecies) D
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)
Glycogen content (muscles)
Coding,
SNP
Sus scrofa domesticus
domestic pig - (subspecies) D
Domesticated
Candidate Gene
Ciobanu D; Bastiaansen J; Malek M ; et al. (2001)
Evidence for new alleles in the protein kinase adenosine monophosphate-activated gamma(3)-subunit ge[...]
GP00002333
Prkag3
Q8BGM7
Physiology
p.(I249V)
Sus scrofa
pig - (species)
Sus scrofa domesticus
domestic pig - (subspecies) D
Muscle-specific adenosine monophosphate-activated protein kinase (PRKAG3)
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
MX1
Pathogen resistance (myxovirus)
Coding,
SNP
Gallus gallus
chicken - (species) D
Intraspecific
Ko JH; Jin HK; Asano A ; et al. (2002)
Polymorphisms and the differential antiviral activity of the chicken Mx gene.
GP00002249
MX1
P20591
Physiology
c.1892G>A p.S631N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
MX1
Gallus gallus
chicken - (species)
Published - Accepted by Curator
MYB1
Coloration (inner flesh)
Cis-regulatory,
Unknown
Beta vulgaris
(species)
Domesticated
Candidate Gene
Hatlestad GJ; Akhavan NA; Sunnadeniya RM ; et al. (2015)
The beet Y locus encodes an anthocyanin MYB-like protein that activates the betalain red pigment pat[...]
GP00001396
MYB1
M1ETA5
Physiology
unknown mutations within 460bp of putative 5 prime UTR
Beta vulgaris
(species)
Beta vulgaris
(species)
MYB1
Beta vulgaris
(species)
Published - Accepted by Curator
MYB1
Coloration (inner flesh)
Cis-regulatory,
Epigenetic Change
Raphanus sativus
radish - (species) D
Domesticated
Candidate Gene
Wang Q; Wang Y; Sun H ; et al. (2020)
Transposon-induced methylation of the RsMYB1 promoter disturbs the anthocyanin accumulation in red-f[...]
GP00002094
MYB1
M1ETA5
Physiology
The taproot white-fleshed mutant is the result of altered DNA methylation in the RsMYB1 promoter. This heritable epigenetic change is due to a hypermethylated CACTA transposon (a 7372-bp TE) which induces the spreading of DNA methylation to the promoter region of RsMYB1. RsMYB1 expression is considerably downregulated and this inhibits anthocyanin biosynthesis in white-fleshed mutants.
Raphanus sativus
radish - (species)
Raphanus sativus
radish - (species) D
MYB1
Raphanus sativus
radish - (species)
Published - Accepted by Curator
Myosin heavy chain 9
Heat tolerance
Racing performance
Cis-regulatory,
SNP
Canis lupus familiaris
dog - (subspecies) D
Domesticated
Association Mapping
Huson HJ; vonHoldt BM; Rimbault M ; et al. (2012)
Breed-specific ancestry studies and genome-wide association analysis highlight an association betwee[...]
GP00000684
MYH9
P35579
Physiology
Physiology
Several candidate SNPs - exact causing mutation(s) unknown
Canis lupus
gray wolf - (species)
Canis lupus familiaris
dog - (subspecies) D
Myosin heavy chain 9
Canis lupus familiaris
dog - (subspecies)
Published - Accepted by Curator
Na/K ATPase
Salt tolerance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001377
ATP1A1
P05023
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Na/K ATPase
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Varanus salvator
water monitor - (species) D
Varanus niloticus
(species) D
Varanus albigularis
cape monitor - (species) D
Interspecific
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000699
Atp1a1
Q8VDN2
Physiology
2 mutations
Varanus tristis
(species)
Varanus mitchelli
(species)
Varanus scalaris
(species)
Varanus salvator
water monitor - (species) D
Varanus niloticus
(species) D
Varanus albigularis
cape monitor - (species) D
Na/K-ATPase alpha-subunit
Varanus salvator
water monitor - (species)
Varanus niloticus
(species)
Varanus albigularis
cape monitor - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Natricinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000700
Atp1a1
Q8VDN2
Physiology
2 mutations
Colubridae
colubrid snakes - (family)
Natricinae
(subfamily) D
Na/K-ATPase alpha-subunit
Natricinae
(subfamily)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Leptodactylus ocellatus
argus frog - (species) D
Intraspecific
Candidate Gene
Moore DJ; Halliday DC; Rowell DM ; et al. (2009)
Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...]
1 Additional References
GP00000701
Atp1a1
Q8VDN2
Physiology
2 mutations
Leptodactylus ocellatus
argus frog - (species)
Leptodactylus ocellatus
argus frog - (species) D
Na/K-ATPase alpha-subunit
Leptodactylus ocellatus
argus frog - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Atelopus spumarius
Pebas stubfoot toad - (species) D
Rhinella marina
marine toad - (species) D
Rhinella granulosa
granular toad - (species) D
Intergeneric or Higher
Candidate Gene
Moore DJ; Halliday DC; Rowell DM ; et al. (2009)
Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...]
1 Additional References
GP00000702
Atp1a1
Q8VDN2
Physiology
2 mutations
Hyloidea
(superfamily)
Atelopus spumarius
Pebas stubfoot toad - (species) D
Rhinella marina
marine toad - (species) D
Rhinella granulosa
granular toad - (species) D
Na/K-ATPase alpha-subunit
Atelopus spumarius
Pebas stubfoot toad - (species)
Rhinella marina
marine toad - (species)
Rhinella granulosa
granular toad - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Naja melanoleuca
forest cobra - (species) D
Naja naja
Indian cobra - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000703
Atp1a1
Q8VDN2
Physiology
2 mutations
Ophiophagus hannah
king cobra - (species)
Pseudechis australis
mulga snake - (species)
Hemiaspis signata
(species)
Naja melanoleuca
forest cobra - (species) D
Naja naja
Indian cobra - (species) D
Na/K-ATPase alpha-subunit
Naja melanoleuca
forest cobra - (species)
Naja naja
Indian cobra - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
4 Mutations:
Coding
SNP
Chrysochus auratus
dogbane beetle - (species) D
Interspecific
Candidate Gene
Aardema ML; Zhen Y; Andolfatto P (2012)
The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies.
1 Additional References
GP00000704
Atp1a1
Q8VDN2
Physiology
4 mutations
Coleoptera
beetles - (order)
Chrysochus auratus
dogbane beetle - (species) D
Na/K-ATPase alpha-subunit
Chrysochus auratus
dogbane beetle - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Rhyssomatus lineaticollis
(species) D
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
GP00000705
K+ ATPase alpha subunit
R4ZHW8
Physiology
C104Y
Coleoptera
beetles - (order)
Rhyssomatus lineaticollis
(species) D
Na/K-ATPase alpha-subunit
Rhyssomatus lineaticollis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Tetraopes tetrophthalmus
red milkweed beetle - (species) D
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
1 Additional References
GP00000706
Atp1a1
Q8VDN2
Physiology
2 mutations
Coleoptera
beetles - (order)
Tetraopes tetrophthalmus
red milkweed beetle - (species) D
Na/K-ATPase alpha-subunit
Tetraopes tetrophthalmus
red milkweed beetle - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides; ouabaine)
4 Mutations:
Coding
SNP
Danaus plexippus
monarch butterfly - (species) D
Danaus erippus
(species) D
Interspecific
Candidate Gene
Aardema ML; Zhen Y; Andolfatto P (2012)
The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies.
3 Additional References
GP00000707
Atp1a1
Q8VDN2
Physiology
4 mutations
Nymphalidae
brushfoots - (family)
Danaus plexippus
monarch butterfly - (species) D
Danaus erippus
(species) D
Na/K-ATPase alpha-subunit
Danaus plexippus
monarch butterfly - (species)
Danaus erippus
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Erinaceus europaeus
western European hedgehog - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000708
Atp1a1
Q8VDN2
Physiology
2 mutations
Condylura cristata
star-nosed mole - (species)
Erinaceus europaeus
western European hedgehog - (species) D
Na/K-ATPase alpha-subunit
Erinaceus europaeus
western European hedgehog - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
4 Mutations:
Coding
SNP
Oncopeltus fasciatus
milkweed bug - (species) D
Lygaeus kalmii
(species) D
Intergeneric or Higher
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
2 Additional References
GP00000709
Atp1a1
Q8VDN2
Physiology
4 mutations
Insecta
true insects - (class)
Oncopeltus fasciatus
milkweed bug - (species) D
Lygaeus kalmii
(species) D
Na/K-ATPase alpha-subunit
Oncopeltus fasciatus
milkweed bug - (species)
Lygaeus kalmii
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Labidomera clivicollis
(species) D
Intergeneric or Higher
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
1 Additional References
GP00000710
Atp1a1
Q8VDN2
Physiology
2 mutations
Insecta
true insects - (class)
Labidomera clivicollis
(species) D
Na/K-ATPase alpha-subunit
Labidomera clivicollis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Liriomyza asclepiadis
(species) D
Interspecific
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
GP00000711
Atp1a1
Q8VDN2
Physiology
N122H
Insecta
true insects - (class)
Liriomyza asclepiadis
(species) D
Na/K-ATPase alpha-subunit
Liriomyza asclepiadis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Aphis nerii
oleander aphid - (species)
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
GP00000712
K+ ATPase alpha subunit
R4ZHW8
Physiology
2 mutations
Insecta
true insects - (class)
Aphis nerii
oleander aphid - (species)
Na/K-ATPase alpha-subunit
Aphis nerii
oleander aphid - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
1 Additional References
GP00000713
Atp1a1
Q8VDN2
Physiology
Q111L
Lepidoptera
butterflies and moths - (order)
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Na/K-ATPase alpha-subunit
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Murinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000714
Atp1a1
Q8VDN2
Physiology
2 mutations
Rodentia
rodent - (order)
Murinae
(subfamily) D
Na/K-ATPase alpha-subunit
Murinae
(subfamily)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Varanus varius
lace monitor - (species) D
Varanus tristis
(species) D
Varanus scalaris
(species) D
Interspecific
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000715
Atp1a1
Q8VDN2
Physiology
2 mutations
Varanus salvator
water monitor - (species)
Varanus rudicollis
roughneck monitor - (species)
Varanus dumerilii
Dumeril monitor - (species)
Varanus varius
lace monitor - (species) D
Varanus tristis
(species) D
Varanus scalaris
(species) D
Na/K-ATPase alpha-subunit
Varanus varius
lace monitor - (species)
Varanus tristis
(species)
Varanus scalaris
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Bitis arietans
puff adder - (species) D
Bitis nasicornis
rhinoceros viper - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000716
Atp1a1
Q8VDN2
Physiology
2 mutations
Vipera berus
adder - (species)
Bitis arietans
puff adder - (species) D
Bitis nasicornis
rhinoceros viper - (species) D
Na/K-ATPase alpha-subunit
Bitis arietans
puff adder - (species)
Bitis nasicornis
rhinoceros viper - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
Unknown
Hydra vulgaris
(species) D
Intergeneric or Higher
Candidate Gene
Canfield VA; Xu KY; D'Aquila T ; et al. (1992)
Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme e[...]
GP00001738
Atp1a1
Q8VDN2
Physiology
Eumetazoa
(no rank)
Hydra vulgaris
(species) D
Na/K-ATPase alpha-subunit
Hydra vulgaris
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Rattus norvegicus
Norway rat - (species) D
Mus musculus
house mouse - (species) D
Mesocricetus auratus
golden hamster - (species) D
Peromyscus maniculatus
North American deer mouse - (species) D
Nannospalax galili
Upper Galilee mountains blind mole rat - (species) D
Intergeneric or Higher
Candidate Gene
Shull GE; Greeb J; Lingrel JB (1986)
Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.
1 Additional References
GP00001739
Atp1a1
Q8VDN2
Physiology
2 mutations
Jaculus jaculus
lesser Egyptian jerboa - (species)
Spermophilus
old world ground squirrels - (genus)
Rattus norvegicus
Norway rat - (species) D
Mus musculus
house mouse - (species) D
Mesocricetus auratus
golden hamster - (species) D
Peromyscus maniculatus
North American deer mouse - (species) D
Nannospalax galili
Upper Galilee mountains blind mole rat - (species) D
Na/K-ATPase alpha-subunit
Rattus norvegicus
Norway rat - (species)
Mus musculus
house mouse - (species)
Mesocricetus auratus
golden hamster - (species)
Peromyscus maniculatus
North American deer mouse - (species)
Nannospalax galili
Upper Galilee mountains blind mole rat - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Oncopeltus fasciatus
milkweed bug - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
1 Additional References
GP00001740
Atp1a1
Q8VDN2
Physiology
Q111T
Lygaeus kalmii
(species)
Oncopeltus fasciatus
milkweed bug - (species) D
Na/K-ATPase alpha-subunit
Oncopeltus fasciatus
milkweed bug - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Liriomyza
(genus) D
Interspecific
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
1 Additional References
GP00001741
Atp1a1
Q8VDN2
Physiology
Q111L
Phytomyzinae
(subfamily)
Liriomyza
(genus) D
Na/K-ATPase alpha-subunit
Liriomyza
(genus)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00001742
Atp1a1
Q8VDN2
Physiology
Q111L
Holometabola
(cohort)
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Na/K-ATPase alpha-subunit
Saucrobotys futilalis
dogbane pyralid moth - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Wang ZJ; Liang CR; Shang ZY ; et al. (2021)
Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]
GP00002491
nAChRbeta1
P04755
Physiology
R81T
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
nAChR
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Wang ZJ; Liang CR; Shang ZY ; et al. (2021)
Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]
GP00002492
nAChRbeta1
P04755
Physiology
K264E
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
nAChR
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Bass C; Puinean AM; Andrews M ; et al. (2011)
Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotin[...]
2 Additional References
GP00002553
nAChRbeta1
P04755
Physiology
R81T in the loop D region of the nAChR β1 subunit of the resistant clone
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
nAChR
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad; spirotetramat)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Puinean AM; Lansdell SJ; Collins T ; et al. (2013)
A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance t[...]
3 Additional References
GP00002554
nAChRbeta1
P04755
Physiology
G275E in nAchR alpha 6 due to a single nucleotide change
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
nAChR
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Thrips palmi
(species) D
Intraspecific
Candidate Gene
Bao WX; Narai Y; Nakano A ; et al. (2014)
Spinosad resistance of melon thrips, Thrips palmi, is conferred by G275E mutation in α6 subunit of n[...]
1 Additional References
GP00002555
nAChRbeta1
P04755
Physiology
G275E in nAchR alpha 6 due to a single nucleotide change
Thrips palmi
(species)
Thrips palmi
(species) D
nAChR
Thrips palmi
(species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Xu X; Ding Q; Wang X ; et al. (2022)
V101I and R81T mutations in the nicotinic acetylcholine receptor β1 subunit are associated with neon[...]
GP00002612
nAChRbeta1
P04755
Physiology
V101I
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
nAChR
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Silva WM; Berger M; Bass C ; et al. (2016)
Mutation (G275E) of the nicotinic acetylcholine receptor α6 subunit is associated with high levels o[...]
1 Additional References
GP00002621
nAChRbeta1
P04755
Physiology
G275E in nAchR alpha 6 due to a single nucleotide change
Tuta absoluta
(species)
Tuta absoluta
(species) D
nAChR
Tuta absoluta
(species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Unknown
N
Bactrocera dorsalis
oriental fruit fly - (species) D
Intraspecific
Candidate Gene
Hsu JC; Feng HT; Wu WJ ; et al. (2012)
Truncated transcripts of nicotinic acetylcholine subunit gene Bdα6 are associated with spinosad resi[...]
GP00002650
CHRNA6
Q15825
Physiology
Mutation in Bdα6 intron 2 (A change to T) just before the truncated/mis-splicing region and in same location with a mutation previously reported in the Pxylα6 gene. Small deletions and insertions leading to premature stop codons in exon 7. N
Bactrocera dorsalis
oriental fruit fly - (species)
Bactrocera dorsalis
oriental fruit fly - (species) D
nAChR
Bactrocera dorsalis
oriental fruit fly - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
SNP
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Chen M; Dawson A ; et al. (2010)
Mis-spliced transcripts of nicotinic acetylcholine receptor alpha6 are associated with field evolved[...]
GP00002651
CHRNA6
Q15825
Physiology
A mutation within the ninth intron splice junction of Pxalpha6 results in mis-splicing of transcripts and produce a predicted protein truncated between the third and fourth transmembrane domains. N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
nAChR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Rinkevich FD; Chen M; Shelton AM ; et al. (2010)
Transcripts of the nicotinic acetylcholine receptor subunit gene Pxylα6 with premature stop codons a[...]
GP00002652
CHRNA6
Q15825
Physiology
transcripts with premature stop codons N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
nAChR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Experimental Evolution
Candidate Gene
Wang J; Wang X; Lansdell SJ ; et al. (2016)
A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 s[...]
GP00002653
CHRNA6
Q15825
Physiology
a three amino acid (3-aa) deletion in the fourth transmembrane domain (TM4) of the nAChR α6 subunit N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
nAChR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Deletion
N
Rhyzopertha dominica
lesser grain borer - (species) D
Intraspecific
Candidate Gene
Wang HT; Tsai CL; Chen ME (2018)
Nicotinic acetylcholine receptor subunit α6 associated with spinosad resistance in Rhyzopertha domin[...]
GP00002654
CHRNA6
Q15825
Physiology
Three mutations were found in the resistant strain compared with the susceptible one: (1) a 181-bp fragment truncated at the N-terminus resulting in the appearance of a premature stop codon - (2) one missing bp at the position 997 causing a frame-shift mutation and (3) an 87-bp fragment truncated in the TM2 region. N
Rhyzopertha dominica
lesser grain borer - (species)
Rhyzopertha dominica
lesser grain borer - (species) D
nAChR
Rhyzopertha dominica
lesser grain borer - (species)
Published - Accepted by Curator
NAM-B1 (=Gpc-B1)
Grain content
Senescence (grain)
Coding,
Insertion
N
Triticum turgidum
(species) D
Domesticated
Linkage Mapping
Uauy C; Distelfeld A; Fahima T ; et al. (2006)
A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat.
GP00000717
NAM-B1
A0SPJ4
Physiology
Physiology
1bp insertion resulting in frameshift N
Triticum turgidum
(species)
Triticum turgidum
(species) D
NAM-B1 (=Gpc-B1)
Triticum turgidum
(species)
Published - Accepted by Curator
Nav1 sodium channel
Xenobiotic resistance (pyrethroid; tau-fluvalinate)
3 Mutations:
Coding
SNP
Bombus impatiens
common eastern bumble bee - (species) D
Apis mellifera
honey bee - (species) D
Dufourea novaeangliae
(species) D
Eufriesea mexicana
(species) D
Habropoda laboriosa
(species) D
Melipona quadrifasciata
(species) D
Megachile rotundata
alfalfa leafcutting bee - (species) D
Athalia rosae
coleseed sawfly - (species) D
Intergeneric or Higher
Candidate Gene
Wu S; Nomura Y; Du Y ; et al. (2017)
Molecular basis of selective resistance of the bumblebee BiNa1 sodium channel to tau-fluvalinate.
GP00002648
SCN8A
Q9UQD0
Physiology
3 mutations
Polistes dominula
European paper wasp - (species)
Orussus abietinus
(species)
Diachasma alloeum
(species)
Bombus impatiens
common eastern bumble bee - (species) D
Apis mellifera
honey bee - (species) D
Dufourea novaeangliae
(species) D
Eufriesea mexicana
(species) D
Habropoda laboriosa
(species) D
Melipona quadrifasciata
(species) D
Megachile rotundata
alfalfa leafcutting bee - (species) D
Athalia rosae
coleseed sawfly - (species) D
Nav1 sodium channel
Bombus impatiens
common eastern bumble bee - (species)
Apis mellifera
honey bee - (species)
Dufourea novaeangliae
(species)
Eufriesea mexicana
(species)
Habropoda laboriosa
(species)
Melipona quadrifasciata
(species)
Megachile rotundata
alfalfa leafcutting bee - (species)
Athalia rosae
coleseed sawfly - (species)
Published - Accepted by Curator
Nav1.6 sodium channel
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species) D
Intraspecific
Candidate Gene
McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014)
Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]
GP00000735
SCN8A
Q9UQD0
Physiology
Ile1709Val
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species) D
Nav1.6 sodium channel
Thamnophis sirtalis
(species)
Published - Accepted by Curator
Nav1.7 sodium channel
Xenobiotic resistance (TTX)
4 Mutations:
Coding
SNP
Thamnophis sirtalis
(species) D
Intraspecific
Candidate Gene
McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014)
Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]
GP00000736
SCN9A
Q15858
Physiology
4 mutations
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species) D
Nav1.7 sodium channel
Thamnophis sirtalis
(species)
Published - Accepted by Curator
NCED4
Seed dormancy
Unknown,
Unknown
Lactuca sativa
(species) D
Domesticated
Linkage Mapping
Argyris J; Truco MJ; Ochoa O ; et al. (2011)
A gene encoding an abscisic acid biosynthetic enzyme (LsNCED4) collocates with the high temperature [...]
1 Additional References
GP00000737
CCD4
O49675
Physiology
unknown
Lactuca serriola
(species)
Lactuca sativa
(species) D
NCED4
Lactuca sativa
(species)
Published - Accepted by Curator
NEK9
Recombination rate
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001663
NEK9
F1MM88
Physiology
On chromosome 10. Associated SNP located 10 kb dowstream
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
NEK9
Bos taurus
cattle - (species)
Published - Accepted by Curator
neurogenin 3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001915
NEUROG3
Q9Y4Z2
Physiology
Absence of the gene in the genome sequence - Neurogenin-3 is a transcription factor whose activity is required for the specification of gastric epithelial cell identity - Deficiency of this factor results in considerably smaller stomachs and absence of gastrin-secreting G cells: somatostatin-secreting D cells and glucagon-secreting A cells N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
neurogenin 3
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
Neverland
Cholesterol metabolism
Ecological specialization
4 Mutations:
Coding
SNP
Drosophila pachea
(species) D
Interspecific
Candidate Gene
Lang M; Murat S; Clark AG ; et al. (2012)
Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.
GP00000738
nvd
Q1JUZ1
Physiology
Physiology
4 mutations
Drosophila acanthoptera
(species)
Drosophila pachea
(species) D
Courtier Virginie
Neverland
Drosophila pachea
(species)
Published - Accepted by Curator
would be good to add text
March 8, 2019 10:00
Not much yang (Nmy)
Sex determination (sex ratio distortion)
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Tao Y; Masly JP; Araripe L ; et al. (2007)
A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor.
1 Additional References
GP00001970
Physiology
Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus and loss of most of the sequence located between the inverted repeats (except for a 93bp element in reverse orientation).
Drosophila simulans
(species)
Drosophila simulans
(species) D
Not much yang (Nmy)
Drosophila simulans
(species)
Published - Accepted by Curator
Nramp aluminum transporter1
Metal tolerance
2 Mutations:
Coding
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Famoso AN; Zhao K; Clark RT ; et al. (2011)
Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide ass[...]
GP00000740
NRAT1
Q6ZG85
Physiology
2 mutations
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Nramp aluminum transporter1
Oryza sativa
rice - (species)
Published - Accepted by Curator
NRT1.1B
Nitrogen use (metabolism)
Coding,
SNP
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Hu B; Wang W; Ou S ; et al. (2015)
Variation in NRT1.1B contributes to nitrate-use divergence between rice subspecies.
GP00001375
NPF6.3
Q05085
Physiology
c.980C>T p.Met327Thr
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
NRT1.1B
Oryza sativa
rice - (species)
Published - Accepted by Curator
NUDT7
Meat color
Cis-regulatory,
Unknown
Sus scrofa domesticus
domestic pig - (subspecies)
Domesticated
Linkage Mapping
Taniguchi M; Hayashi T; Nii M ; et al. (2010)
Fine mapping of quantitative trait loci for meat color on Sus scrofa chromosome 6: analysis of the s[...]
1 Additional References
GP00000741
Nudt7
Q99P30
Physiology
unknown
Sus scrofa
pig - (species)
Sus scrofa domesticus
domestic pig - (subspecies)
NUDT7
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
Nup160
Hybrid incompatibility (F1 male sterility)
Coding,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Tang S; Presgraves DC (2009)
Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.
GP00000742
Nup160
Q9VKJ3
Physiology
Coding divergence
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Nup160
Drosophila simulans
(species)
Published - Accepted by Curator
Nup96
Hybrid incompatibility (F1 male sterility)
Coding,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Presgraves DC; Balagopalan L; Abmayr SM ; et al. (2003)
Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.
GP00000743
NUP96
Q8LLD0
Physiology
Coding divergence
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Nup96
Drosophila simulans
(species)
Published - Accepted by Curator
nurf-1
Fertility (reproductive timing; egg laying rate)
Lifespan
Growth rate
Diapause (dauer formation)
Coding,
Deletion
Caenorhabditis elegans
(species) D
Domesticated
Linkage Mapping
Large EE; Xu W; Zhao Y ; et al. (2016)
Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticate[...]
GP00001318
nurf-1
Q6BER5
Physiology
Physiology
Physiology
Physiology
60bp deletion
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
nurf-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
NV10127-NV10128-NV10129 gene cluster
Pheromone production (isomeric/chirality divergence)
Unknown,
Unknown
Nasonia giraulti
(species)
Interspecific
Linkage Mapping
Niehuis O; Buellesbach J; Gibson JD ; et al. (2013)
Behavioural and genetic analyses of Nasonia shed light on the evolution of sex pheromones.
GP00000744
NV10127
L8BRU0
Physiology
Not identified. Gene conversion between the three paralogues in tandem
Nasonia vitripennis
jewel wasp - (species)
Nasonia giraulti
(species)
NV10127-NV10128-NV10129 gene cluster
Nasonia giraulti
(species)
Published - Accepted by Curator
Oca2
Coloration (albinism)
Catecholamine metabolism
Coding,
Deletion
N
Astyanax mexicanus
Mexican tetra - (species) D
Intraspecific
Linkage Mapping
Protas ME; Hersey C; Kochanek D ; et al. (2006)
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism.
2 Additional References
GP00000745
Oca2
Q62052
Morphology
Physiology
Deletion of exon 21 N
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species) D
Oca2
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
Oca2
Coloration (albinism)
Catecholamine metabolism
Coding,
Deletion
N
Astyanax mexicanus
Mexican tetra - (species) D
Intraspecific
Linkage Mapping
Protas ME; Hersey C; Kochanek D ; et al. (2006)
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism.
2 Additional References
GP00000746
Oca2
Q62052
Morphology
Physiology
Almost complete deletion of exon 24; + 2 a.a subsitutions at conserved positions - the two point mutations do not drastically affect the function of OCA2 in cell lines suggesting that the exon 24 deletion is the mutation that causes albinism in the Pachón population N
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species) D
Oca2
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
ocimene synthase (OS)
Pheromone production (cuticular hydrocarbons ; beta-ocimene)
Coding,
Unknown
Heliconius cydno
(species) D
Interspecific
Linkage Mapping
Darragh K; Orteu A; Black D ; et al. (2021)
A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between close[...]
GP00002426
TPS
A0A7D0AGU9
Physiology
gain of expression - in vitro assay of the protein activity in E. coli - several amino acid changes between the 2 species
Heliconius melpomene
postman butterfly - (species)
Heliconius cydno
(species) D
ocimene synthase (OS)
Heliconius cydno
(species)
Published - Accepted by Curator
OCYMENE SYNTHASE (OS)
Fragrance (floral terpenoid volatiles; E- beta-ocimene)
Coding,
SNP
N
Erythranthe cardinalis
(species) D
Interspecific
Linkage Mapping
Byers KJ; Vela JP; Peng F ; et al. (2014)
Floral volatile alleles can contribute to pollinator-mediated reproductive isolation in monkeyflower[...]
1 Additional References
GP00001760
TPS02
P0CJ43
Physiology
multiple candidate coding sequence differences - together they eliminate the ability of the enzyme to produce E-beta-ocimene - effect of individual mutations not tested N
Erythranthe lewisii
(species)
Erythranthe cardinalis
(species) D
OCYMENE SYNTHASE (OS)
Erythranthe cardinalis
(species)
Published - Accepted by Curator
OCYMENE SYNTHASE (OS)
Fragrance (floral terpenoid volatiles; E- beta-ocimene)
Coding,
Deletion
N
Erythranthe verbenacea
(species) D
Interspecific
Candidate Gene
Peng F; Byers KJRP; Bradshaw HD (2017)
Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]
GP00001762
TPS02
P0CJ43
Physiology
large deletion from the third exon to the last exon N
Erythranthe lewisii
(species)
Erythranthe verbenacea
(species) D
OCYMENE SYNTHASE (OS)
Erythranthe verbenacea
(species)
Published - Accepted by Curator
OCYMENE SYNTHASE (OS)
Fragrance (floral terpenoid volatiles; E- beta-ocimene)
Coding,
Insertion
N
Erythranthe bicolor
(species) D
Interspecific
Candidate Gene
Peng F; Byers KJRP; Bradshaw HD (2017)
Less is more: Independent loss-of-function OCIMENE SYNTHASE alleles parallel pollination syndrome di[...]
GP00001763
TPS02
P0CJ43
Physiology
2-bp insertion in the second exon, producing a frameshift mutation and premature termination N
Erythranthe lewisii
(species)
Erythranthe bicolor
(species) D
OCYMENE SYNTHASE (OS)
Erythranthe bicolor
(species)
Published - Accepted by Curator
ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]
Fragrance
Cis-regulatory,
Unknown
Petunia exserta
(species)
Interspecific
Linkage Mapping
Klahre U; Gurba A; Hermann K ; et al. (2011)
Pollinator choice in Petunia depends on two major genetic Loci for floral scent production.
GP00000750
ODO1
Q50EX6
Physiology
Not identified; but probably homologous to P. hybrida Mitchell x R27 promoter variation since these P. hybrida accessions are derived from a P. axillaris x P. integrifolia cross
Petunia axillaris
(species)
Petunia exserta
(species)
ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]
Petunia exserta
(species)
Published - Accepted by Curator
ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]
Fragrance
Cis-regulatory,
SNP
Petunia x hybrida
(species)
Domesticated
Linkage Mapping
Van Moerkercke A; Haring MA; Schuurink RC (2011)
The transcription factor EMISSION OF BENZENOIDS II activates the MYB ODORANT1 promoter at a MYB bind[...]
GP00000751
ODO1
Q50EX6
Physiology
C/T substitution in enhancer region MYB-TF binding site
Petunia x hybrida
(species)
Petunia x hybrida
(species)
ODORANT1 [pseudo-replication between 2 ODO1 entries due to possible homology between alleles]
Petunia x hybrida
(species)
Published - Accepted by Curator
Odysseus-site homeobox
Hybrid incompatibility (F1 male sterility)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Bayes JJ; Malik HS (2009)
Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species.
GP00000752
OdsH
Q9VX20
Physiology
Rapid coding divergence
Drosophila mauritiana
(species)
Drosophila simulans
(species)
Odysseus-site homeobox
Drosophila simulans
(species)
Published - Accepted by Curator
opaque2 (O2)
Lysine content (endosperm)
Coding,
Deletion
N
Zea mays
(species) D
Domesticated
Linkage Mapping
Schmidt RJ; Burr FA; Burr B (1987)
Transposon tagging and molecular analysis of the maize regulatory locus opaque-2.
1 Additional References
GP00000753
O2
P12959
Physiology
1bp deletion predicted to cause premature termination of translation N
Zea mays
(species)
Zea mays
(species) D
opaque2 (O2)
Zea mays
(species)
Published - Accepted by Curator
opaque2 (O2)
Lysine content (endosperm)
Cis-regulatory,
Insertion
Zea mays
(species) D
Domesticated
Linkage Mapping
Schmidt RJ; Burr FA; Burr B (1987)
Transposon tagging and molecular analysis of the maize regulatory locus opaque-2.
GP00000754
O2
P12959
Physiology
insertion of a non-autonomous rbg transposable element in the untranslated leader sequence of the O2 gene
Zea mays
(species)
Zea mays
(species) D
opaque2 (O2)
Zea mays
(species)
Published - Accepted by Curator
opsin
Color vision (blue)
Coding,
SNP
Alloteuthis subulata
(species)
Interspecific
Candidate Gene
Morris A; Bowmaker JK; Hunt DM (1993)
The molecular basis of a spectral shift in the rhodopsins of two species of squid from different pho[...]
GP00000755
opn1sw1
Q9W6A9
Physiology
F270S
Loligo forbesii
northern European squid - (species)
Alloteuthis subulata
(species)
opsin
Alloteuthis subulata
(species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision
Coding,
Deletion
N
Mysticeti
baleen whales - (suborder) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000756
OPN1SW
P03999
Physiology
4bp frameshift deletion in exon 1 of SWS1 that results in a premature stop codon N
Cetacea
whales - (order)
Mysticeti
baleen whales - (suborder) D
opsin - (SWS1)
Mysticeti
baleen whales - (suborder)
Published - Accepted by Curator
opsin - (SWS1)
Color vision
Coding,
SNP
Odontoceti
tooth whales - (suborder)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000757
OPN1SW
P03999
Physiology
E113G; disrupts opsin-chromophore binding
Cetacea
whales - (order)
Odontoceti
tooth whales - (suborder)
opsin - (SWS1)
Odontoceti
tooth whales - (suborder)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (loss of violet-range sensitivity)
Coding,
Deletion
N
Sciurus carolinensis
gray squirrel - (species) D
Intergeneric or Higher
Candidate Gene
Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006)
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.
GP00000758
OPN1SW
P03999
Physiology
6bp deletion (residues 77-78) + 1bp frameshift deletion N
Sciurus carolinensis
gray squirrel - (species)
Sciurus carolinensis
gray squirrel - (species) D
opsin - (SWS1)
Sciurus carolinensis
gray squirrel - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (loss of violet-range sensitivity)
Coding,
Deletion
Sciurus carolinensis
gray squirrel - (species) D
Intergeneric or Higher
Candidate Gene
Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006)
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.
GP00000759
OPN1SW
P03999
Physiology
9bp deletion (residues 93-95)
Sciurus carolinensis
gray squirrel - (species)
Sciurus carolinensis
gray squirrel - (species) D
opsin - (SWS1)
Sciurus carolinensis
gray squirrel - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Melopsittacus undulatus
budgerigar - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Radlwimmer FB; Blow NS (2000)
Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change.
1 Additional References
GP00000760
OPN1SW
P03999
Physiology
2 mutations
Aves
birds - (class)
Melopsittacus undulatus
budgerigar - (species) D
opsin - (SWS1)
Melopsittacus undulatus
budgerigar - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Rhea americana
greater rhea - (species) D
Intergeneric or Higher
Candidate Gene
Odeen A; Hastad O (2003)
Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...]
2 Additional References
GP00000761
OPN1SW
P03999
Physiology
2 mutations
Aves
birds - (class)
Rhea americana
greater rhea - (species) D
opsin - (SWS1)
Rhea americana
greater rhea - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Larus
(genus) D
Intergeneric or Higher
Candidate Gene
Odeen A; Hastad O (2003)
Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...]
1 Additional References
GP00000762
OPN1SW
P03999
Physiology
2 mutations
Aves
birds - (class)
Larus
(genus) D
opsin - (SWS1)
Larus
(genus)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
Coding,
SNP
Trogon curucui
(species) D
Intergeneric or Higher
Candidate Gene
Odeen A; Hastad O (2003)
Complex distribution of avian color vision systems revealed by sequencing the SWS1 opsin from total [...]
1 Additional References
GP00000763
OPN1SW
P03999
Physiology
S86F
Aves
birds - (class)
Trogon curucui
(species) D
opsin - (SWS1)
Trogon curucui
(species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
Coding,
SNP
Taeniopygia guttata
zebra finch - (species)
Intergeneric or Higher
Candidate Gene
Yokoyama S; Radlwimmer FB; Blow NS (2000)
Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change.
1 Additional References
GP00000764
OPN1SW
P03999
Physiology
S90C
Passeriformes
(order)
Taeniopygia guttata
zebra finch - (species)
opsin - (SWS1)
Taeniopygia guttata
zebra finch - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
3 Mutations:
Coding
SNP
Xenopus laevis
African clawed frog - (species) D
Intergeneric or Higher
Candidate Gene
Takahashi Y; Yokoyama S (2005)
Genetic basis of spectral tuning in the violet-sensitive visual pigment of African clawed frog, Xeno[...]
GP00000765
OPN1SW
P03999
Physiology
3 mutations
Amniota
amniotes - (no rank)
Xenopus laevis
African clawed frog - (species) D
opsin - (SWS1)
Xenopus laevis
African clawed frog - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
SNP
Macropodidae
(family)
Intergeneric or Higher
Candidate Gene
Deeb SS; Wakefield MJ; Tada T ; et al. (2003)
The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence[...]
1 Additional References
GP00000766
OPN1SW
P03999
Physiology
F86Y
Metatheria
marsupials - (no rank)
Macropodidae
(family)
opsin - (SWS1)
Macropodidae
(family)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
SNP
Cavia porcellus
domestic guinea pig - (species)
Intergeneric or Higher
Candidate Gene
Parry JW; Poopalasundaram S; Bowmaker JK ; et al. (2004)
A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visu[...]
GP00000767
OPN1SW
P03999
Physiology
F86V
Rodentia
rodent - (order)
Cavia porcellus
domestic guinea pig - (species)
opsin - (SWS1)
Cavia porcellus
domestic guinea pig - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
SNP
Sciurus carolinensis
gray squirrel - (species)
Intergeneric or Higher
Candidate Gene
Carvalho Ldos S; Cowing JA; Wilkie SE ; et al. (2006)
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle.
GP00000768
OPN1SW
P03999
Physiology
F86Y
Rodentia
rodent - (order)
Sciurus carolinensis
gray squirrel - (species)
opsin - (SWS1)
Sciurus carolinensis
gray squirrel - (species)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (UV-shift)
Coding,
SNP
Aves
birds - (class) D
Intergeneric or Higher
Candidate Gene
Carvalho LS; Cowing JA; Wilkie SE ; et al. (2007)
The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.
1 Additional References
GP00001694
OPN1SW
P03999
Physiology
V116L
Vertebrata
vertebrates - (no rank)
Aves
birds - (class) D
opsin - (SWS1)
Aves
birds - (class)
Published - Accepted by Curator
opsin - (SWS1)
Color vision (violet-shift)
Coding,
Deletion
Lepidopus fitchi
(species) D
Intergeneric or Higher
Candidate Gene
Tada T; Altun A; Yokoyama S (2009)
Evolutionary replacement of UV vision by violet vision in fish.
GP00001704
OPN1SW
P03999
Physiology
deletion of Phe86 (3-bp deletion)
Actinopterygii
ray-finned fishes - (superclass)
Lepidopus fitchi
(species) D
opsin - (SWS1)
Lepidopus fitchi
(species)
Published - Accepted by Curator
opsin - (SWS2)
Color vision (blue- and red-shifts)
2 Mutations:
Coding
SNP
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Candidate Gene
Marques DA; Taylor JS; Jones FC ; et al. (2017)
Convergent evolution of SWS2 opsin facilitates adaptive radiation of threespine stickleback into dif[...]
GP00001679
opn1sw2
Q9W6A8
Physiology
2 mutations
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
opsin - (SWS2)
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
opsin - (SWS2)
Color vision
3 Mutations:
Coding
SNP
Cottus gobio
bullhead - (species) D
Intergeneric or Higher
Candidate Gene
Cowing JA; Poopalasundaram S; Wilkie SE ; et al. (2002)
Spectral tuning and evolution of short wave-sensitive cone pigments in cottoid fish from Lake Baikal[...]
GP00001771
opn1sw2
Q9W6A8
Physiology
3 mutations
Cottidae
sculpins - (family)
Cottus gobio
bullhead - (species) D
opsin - (SWS2)
Cottus gobio
bullhead - (species)
Published - Accepted by Curator
opsin - (SWS2B)
Color vision
Coding,
SNP
Tramitichromis intermedius
(species)
Interspecific
Candidate Gene
O'Quin KE; Schulte JE; Patel Z ; et al. (2012)
Evolution of cichlid vision via trans-regulatory divergence.
GP00001440
opn1sw2
Q9W6A8
Physiology
Ala269Thr causing a 10nm Spectral Sensitivity Shift
Aulonocara baenschi
Nkhomo-benga peacock cichlid - (species)
Tramitichromis intermedius
(species)
opsin - (SWS2B)
Tramitichromis intermedius
(species)
Published - Accepted by Curator
opsin - rhodopsin (LWRh)
Color vision (blue shift)
2 Mutations:
Coding
SNP
Limenitis archippus
viceroy - (species)
Intergeneric or Higher
Candidate Gene
Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007)
Adaptive evolution of color vision as seen through the eyes of butterflies.
GP00000769
LWRh
E2DZP1
Physiology
2 mutations
Limenitis arthemis
white admiral - (species)
Limenitis archippus
viceroy - (species)
opsin - rhodopsin (LWRh)
Limenitis archippus
viceroy - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWRh)
Color vision (blue shift)
2 Mutations:
Coding
SNP
Junonia
buckeyes - (genus)
Intergeneric or Higher
Candidate Gene
Frentiu FD; Bernard GD; Cuevas CI ; et al. (2007)
Adaptive evolution of color vision as seen through the eyes of butterflies.
GP00000770
LWRh
E2DZP1
Physiology
2 mutations
Nymphalidae
brushfoots - (family)
Junonia
buckeyes - (genus)
opsin - rhodopsin (LWRh)
Junonia
buckeyes - (genus)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Deletion
N
Balaenopteridae
rorquals - (family) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000771
OPN1LW
P04000
Physiology
22bp deletion including transciption start N
Cetacea
whales - (order)
Balaenopteridae
rorquals - (family) D
opsin - rhodopsin (LWS)
Balaenopteridae
rorquals - (family)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Deletion
N
Kogia breviceps
pygmy sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000772
OPN1LW
P04000
Physiology
44bp frameshift deletion 9 + possibly GT to CT splice site mutation N
Cetacea
whales - (order)
Kogia breviceps
pygmy sperm whale - (species) D
opsin - rhodopsin (LWS)
Kogia breviceps
pygmy sperm whale - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Deletion
N
Physeter catodon
sperm whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000773
OPN1LW
P04000
Physiology
1bp + 28bp frameshift deletions N
Cetacea
whales - (order)
Physeter catodon
sperm whale - (species) D
opsin - rhodopsin (LWS)
Physeter catodon
sperm whale - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
Insertion
N
Mesoplodon bidens
Sowerby's beaked whale - (species) D
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000774
OPN1LW
P04000
Physiology
4bp frameshift insertion in exon 2 of LWS N
Cetacea
whales - (order)
Mesoplodon bidens
Sowerby's beaked whale - (species) D
opsin - rhodopsin (LWS)
Mesoplodon bidens
Sowerby's beaked whale - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Coding,
SNP
Balaenidae
right whales - (family)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000775
OPN1LW
P04000
Physiology
AG to GG splice site mutation
Cetacea
whales - (order)
Balaenidae
right whales - (family)
opsin - rhodopsin (LWS)
Balaenidae
right whales - (family)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision (blue shift)
Coding,
SNP
Neochromis greenwoodi
(species)
Interspecific
Candidate Gene
Terai Y; Seehausen O; Sasaki T ; et al. (2006)
Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids.
GP00000776
OPN1LW
P04000
Physiology
Candidate mutations are CS180A and/or I277C (human LWS/MWS numbering)
African cichlids
(no rank)
Neochromis greenwoodi
(species)
opsin - rhodopsin (LWS)
Neochromis greenwoodi
(species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision (blue shift)
3 Mutations:
Coding
SNP
Pundamilia pundamilia
(species)
Intraspecific
Candidate Gene
Seehausen O; Terai Y; Magalhaes IS ; et al. (2008)
Speciation through sensory drive in cichlid fish.
GP00000777
OPN1LW
P04000
Physiology
3 mutations
Pundamilia pundamilia
(species)
Pundamilia pundamilia
(species)
opsin - rhodopsin (LWS)
Pundamilia pundamilia
(species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision (blue-shift)
Coding,
SNP
Tursiops truncatus
bottlenose dolphin - (species) D
Intergeneric or Higher
Candidate Gene
Fasick JI; Robsinson PR (1998)
Mechanism of spectral tuning in the dolphin visual pigments.
GP00001703
OPN1LW
P04000
Physiology
A292S
Mammalia
mammals - (class)
Tursiops truncatus
bottlenose dolphin - (species) D
opsin - rhodopsin (LWS)
Tursiops truncatus
bottlenose dolphin - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision
Gene Loss,
Deletion
N
Sinocyclocheilus anshuiensis
(species) D
Sinocyclocheilus grahami
(species) D
Sinocyclocheilus rhinocerous
(species) D
Interspecific
Candidate Gene
Yang J; Chen X; Bai J ; et al. (2016)
The Sinocyclocheilus cavefish genome provides insights into cave adaptation.
GP00002353
OPN1LW
P04000
Physiology
Lws2 coding sequence absent from the full genome sequence N
Danio rerio
zebrafish - (species)
Sinocyclocheilus anshuiensis
(species) D
Sinocyclocheilus grahami
(species) D
Sinocyclocheilus rhinocerous
(species) D
opsin - rhodopsin (LWS)
Sinocyclocheilus anshuiensis
(species)
Sinocyclocheilus grahami
(species)
Sinocyclocheilus rhinocerous
(species)
Published - Accepted by Curator
opsin - rhodopsin (MWS=duplicate of LWS)
Color vision (green-shift)
7 Mutations:
Coding
SNP
Catarrhini
(parvorder)
Intergeneric or Higher
Candidate Gene
Asenjo AB; Rim J; Oprian DD (1994)
Molecular determinants of human red/green color discrimination.
1 Additional References
GP00000778
OPN1MW
P04001
Physiology
7 mutations
Primates
(order)
Catarrhini
(parvorder)
opsin - rhodopsin (MWS=duplicate of LWS)
Catarrhini
(parvorder)
Published - Accepted by Curator
opsin - rhodopsin (UVRh2)
Color vision (UV-shift)
2 Mutations:
Coding
SNP
Heliconius pachinus
(species)
Heliconius erato
crimson-patched longwing - (species)
Heliconius hortense
(species)
Heliconius sapho
(species)
Heliconius charithonia
zebra longwing - (species)
Heliconius melpomene
postman butterfly - (species)
Heliconius elevatus
(species)
Heliconius cydno
(species)
Intergeneric or Higher
Candidate Gene
Briscoe AD; Bybee SM; Bernard GD ; et al. (2010)
Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution[...]
1 Additional References
GP00000779
UVRh2
E2DZL8
Physiology
2 mutations
Nymphalidae
brushfoots - (family)
Heliconius pachinus
(species)
Heliconius erato
crimson-patched longwing - (species)
Heliconius hortense
(species)
Heliconius sapho
(species)
Heliconius charithonia
zebra longwing - (species)
Heliconius melpomene
postman butterfly - (species)
Heliconius elevatus
(species)
Heliconius cydno
(species)
opsin - rhodopsin (UVRh2)
Heliconius pachinus
(species)
Heliconius erato
crimson-patched longwing - (species)
Heliconius hortense
(species)
Heliconius sapho
(species)
Heliconius charithonia
zebra longwing - (species)
Heliconius melpomene
postman butterfly - (species)
Heliconius elevatus
(species)
Heliconius cydno
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
2 Mutations:
Coding
SNP
undetermined Cottoidei 'Lake Baikal'
(species)
Intergeneric or Higher
Candidate Gene
Hunt DM; Fitzgibbon J; Slobodyanyuk SJ ; et al. (1996)
Spectral tuning and molecular evolution of rod visual pigments in the species flock of cottoid fish [...]
GP00000780
RHO
P08100
Physiology
2 mutations
undetermined Cottoidei 'Lake Baikal'
(species)
undetermined Cottoidei 'Lake Baikal'
(species)
opsin - rhodopsin1 (RH1)
undetermined Cottoidei 'Lake Baikal'
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
Coding,
SNP
Megaderma lyra
Indian false vampire - (species) D
Intergeneric or Higher
Candidate Gene
Sugawara T; Imai H; Nikaido M ; et al. (2010)
Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.
GP00000781
RHO
P08100
Physiology
D83N
Chiroptera
bats - (order)
Megaderma lyra
Indian false vampire - (species) D
opsin - rhodopsin1 (RH1)
Megaderma lyra
Indian false vampire - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
2 Mutations:
Coding
SNP
Sebastolobus altivelis
(species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T; Yamato T (2007 Mar-Apr)
Modulation of the absorption maximum of rhodopsin by amino acids in the C-terminus.
1 Additional References
GP00000782
RHO
P08100
Physiology
2 mutations
Teleostei
teleost fishes - (infraclass)
Sebastolobus altivelis
(species) D
opsin - rhodopsin1 (RH1)
Sebastolobus altivelis
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue shift)
Coding,
SNP
Flaveria trinervia
(species)
Intergeneric or Higher
Candidate Gene
Sugawara T; Imai H; Nikaido M ; et al. (2010)
Vertebrate rhodopsin adaptation to dim light via rapid meta-II intermediate formation.
GP00000783
RHO
P08100
Physiology
D83N
Vespertilionidae
common bats - (family)
Flaveria trinervia
(species)
opsin - rhodopsin1 (RH1)
Flaveria trinervia
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
Squamata
squamates - (order) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Zhang H; Radlwimmer FB ; et al. (1999)
Adaptive evolution of color vision of the Comoran coelacanth (Latimeria chalumnae).
1 Additional References
GP00000784
RHO
P08100
Physiology
D83N
Amniota
amniotes - (no rank)
Squamata
squamates - (order) D
opsin - rhodopsin1 (RH1)
Squamata
squamates - (order)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
2 Mutations:
Coding
SNP
Orcinus orca
killer whale - (species) D
Intergeneric or Higher
Candidate Gene
Dungan SZ; Kosyakov A; Chang BS (2016)
Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functi[...]
1 Additional References
GP00000785
RHO
P08100
Physiology
2 mutations
Bos taurus
cattle - (species)
Orcinus orca
killer whale - (species) D
opsin - rhodopsin1 (RH1)
Orcinus orca
killer whale - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
African cichlids
(no rank)
Intergeneric or Higher
Candidate Gene
Sugawara T; Terai Y; Imai H ; et al. (2005)
Parallelism of amino acid changes at the RH1 affecting spectral sensitivity among deep-water cichlid[...]
1 Additional References
GP00000786
RHO
P08100
Physiology
A292S and reversals; many independent cases
African cichlids
(no rank)
African cichlids
(no rank)
opsin - rhodopsin1 (RH1)
African cichlids
(no rank)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
3 Mutations:
Coding
SNP
Tursiops truncatus
bottlenose dolphin - (species)
Intergeneric or Higher
Candidate Gene
Fasick JI; Robsinson PR (1998)
Mechanism of spectral tuning in the dolphin visual pigments.
2 Additional References
GP00000787
RHO
P08100
Physiology
3 mutations
Mammalia
mammals - (class)
Tursiops truncatus
bottlenose dolphin - (species)
opsin - rhodopsin1 (RH1)
Tursiops truncatus
bottlenose dolphin - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
Elephantidae
elephants - (family)
Intergeneric or Higher
Candidate Gene
Yokoyama S; Takenaka N; Agnew DW ; et al. (2005)
Elephants and human color-blind deuteranopes have identical sets of visual pigments.
1 Additional References
GP00000788
RHO
P08100
Physiology
D83N
Mammalia
mammals - (class)
Elephantidae
elephants - (family)
opsin - rhodopsin1 (RH1)
Elephantidae
elephants - (family)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
Coding,
SNP
Physeteridae
sperm whales - (family)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000789
RHO
P08100
Physiology
K195T
Cetacea
whales - (order)
Physeteridae
sperm whales - (family)
opsin - rhodopsin1 (RH1)
Physeteridae
sperm whales - (family)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
2 Mutations:
Coding
SNP
Latimeria menadoensis
Menado coelacanth - (species) D
Latimeria chalumnae
coelacanth - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T (2000)
Adaptive evolution of the African and Indonesian coelacanths to deep-sea environments.
GP00000790
RHO
P08100
Physiology
2 mutations
Teleostei
teleost fishes - (infraclass)
Latimeria menadoensis
Menado coelacanth - (species) D
Latimeria chalumnae
coelacanth - (species) D
opsin - rhodopsin1 (RH1)
Latimeria menadoensis
Menado coelacanth - (species)
Latimeria chalumnae
coelacanth - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (blue-shift)
2 Mutations:
Coding
SNP
Cetacea
whales - (order)
Intergeneric or Higher
Candidate Gene
Meredith RW; Gatesy J; Emerling CA ; et al. (2013)
Rod monochromacy and the coevolution of cetacean retinal opsins.
GP00000791
RHO
P08100
Physiology
2 mutations
Mammalia
mammals - (class)
Cetacea
whales - (order)
opsin - rhodopsin1 (RH1)
Cetacea
whales - (order)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (red-shift)
Coding,
SNP
Aristostomias scintillans
shiny loosejaw - (species)
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T; Zhang H ; et al. (2008)
Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]
1 Additional References
GP00000792
RHO
P08100
Physiology
D83N; M183F; M253L; F261Y; T289G; S292I; M317I - all together shift to red (see table S4 of Yokoyama PNAS) - individual changes not tested
Stomiidae
barbeled dragonfishes - (family)
Aristostomias scintillans
shiny loosejaw - (species)
opsin - rhodopsin1 (RH1)
Aristostomias scintillans
shiny loosejaw - (species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (green-shift)
Coding,
SNP
Stomoxys calcitrans
stable fly - (species)
Intraspecific
Candidate Gene
Olafson PU; Aksoy S; Attardo GM ; et al. (2021)
The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduct[...]
GP00002535
RHO
P08100
Physiology
Met>Leucine residue present at tuning site 17 which is extremely rare across insect LW opsins. In a survey of over 100 insect LW opsins it was detected only in the two corresponding Rh1 orthologs from M. domestica in addition to one in the distantly related species of thrips (Thysanoptera). The site is residue 17 based on the numbering system developed for butterflies which corresponds to residue 57 in Drosophila Rh1.
Stomoxys calcitrans
stable fly - (species)
Stomoxys calcitrans
stable fly - (species)
opsin - rhodopsin1 (RH1)
Stomoxys calcitrans
stable fly - (species)
Published - Accepted by Curator
opsin - rhodopsin1-A (RH1-A)
Color vision (blue shift)
3 Mutations:
Coding
SNP
Conger myriaster
whitespotted conger - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Tada T; Zhang H ; et al. (2008)
Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrate[...]
GP00000793
RHO
P08100
Physiology
3 mutations
Anguilla japonica
Japanese eel - (species)
Conger myriaster
whitespotted conger - (species) D
opsin - rhodopsin1-A (RH1-A)
Conger myriaster
whitespotted conger - (species)
Published - Accepted by Curator
opsin - rhodopsin1-B (RH1-B)
Color vision (blue shift)
Coding,
SNP
Anguilla japonica
Japanese eel - (species) D
Intergeneric or Higher
Candidate Gene
Yokoyama S; Takenaka N; Agnew DW ; et al. (2005)
Elephants and human color-blind deuteranopes have identical sets of visual pigments.
1 Additional References
GP00000794
RHO
P08100
Physiology
D83N
Conger myriaster
whitespotted conger - (species)
Anguilla japonica
Japanese eel - (species) D
opsin - rhodopsin1-B (RH1-B)
Anguilla japonica
Japanese eel - (species)
Published - Accepted by Curator
Or22a
Olfaction
Coding,
SNP
Drosophila sechellia
(species) D
Drosophila simulans
(species) D
Drosophila mauritiana
(species) D
Interspecific
Candidate Gene
Auer TO; Khallaf MA; Silbering AF ; et al. (2020)
Olfactory receptor and circuit evolution promote host specialization.
GP00002183
Or22a
P81909
Physiology
Effect of the mutation tested in a Or22a construct which rescues the Or22a knock-down mutation in D. melanogaster.There are two other amino acid changes that may have an effect as well.
Drosophila melanogaster
fruit fly - (species)
Drosophila sechellia
(species) D
Drosophila simulans
(species) D
Drosophila mauritiana
(species) D
Or22a
Drosophila sechellia
(species)
Drosophila simulans
(species)
Drosophila mauritiana
(species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
1 Additional References
GP00000799
OR7D4
Q8NG98
Physiology
P79L
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
GP00000800
OR7D4
Q8NG98
Physiology
R227G
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
GP00000801
OR7D4
Q8NG98
Physiology
T133M
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
GP00000802
OR7D4
Q8NG98
Physiology
S84N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species) D
Interspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
1 Additional References
GP00000803
OR7D4
Q8NG98
Physiology
R227G
Homininae
(subfamily)
Homo sapiens
human - (species) D
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species) D
Interspecific
Candidate Gene
Zhuang H; Chien MS; Matsunami H (2009)
Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates.
GP00000804
OR7D4
Q8NG98
Physiology
M273T
Homininae
(subfamily)
Homo sapiens
human - (species) D
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
ORGANIC CATION TRANSPORTER 1
Root growth (root length response to exogenous cadaverine)
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Strohm AK; Vaughn LM; Masson PH (2015)
Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to[...]
GP00001279
OCT1
Q9CAT6
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ORGANIC CATION TRANSPORTER 1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Os07g0603400
Grain size
Grain quality
2 Mutations:
Coding
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Wang Y; Xiong G; Hu J ; et al. (2015)
Copy number variation at the GL7 locus contributes to grain size diversity in rice.
GP00001542
Os07g0603400
A3BLY4
Morphology
Physiology
2 mutations
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Os07g0603400
Oryza sativa
rice - (species)
Published - Accepted by Curator
OsGA20ox1
Seedling vigor
Cis-regulatory,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Abe A; Takagi H; Fujibe T ; et al. (2012)
OsGA20ox1, a candidate gene for a major QTL controlling seedling vigor in rice.
GP00000810
GA20OX1
P93771
Physiology
unknown ; no coding variation
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
OsGA20ox1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Overdrive
Hybrid incompatibility (male F1 sterility)
Coding,
SNP
Drosophila pseudoobscura
(species)
Intraspecific
Linkage Mapping
Phadnis N; Orr HA (2009)
A single gene causes both male sterility and segregation distortion in Drosophila hybrids.
GP00000816
Ovd
Q2LZF7
Physiology
6 candidate non-synonymous changes - the effect of single amino acid changes has not been tested
Drosophila pseudoobscura
(species)
Drosophila pseudoobscura
(species)
Overdrive
Drosophila pseudoobscura
(species)
Published - Accepted by Curator
PABPN1
Recombination rate
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001660
PABPN1
Q28165
Physiology
On chromosome 10. Associated SNP located dowstream of PABPN1
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
PABPN1
Bos taurus
cattle - (species)
Published - Accepted by Curator
PAP1
Coloration (anthocyanin accumulation under high-light and low-temperature stress)
Gene Loss,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ilk N; Ding J; Ihnatowicz A ; et al. (2015)
Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]
1 Additional References
GP00001232
MYB75
Q9FE25
Physiology
several deletions in the promoter; first intron; second exon and 3' UTR region (putative loss of function) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PAP1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
PAP2
Coloration (anthocyanin accumulation under high-light and low-temperature stress)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ilk N; Ding J; Ihnatowicz A ; et al. (2015)
Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]
GP00001231
MYB90
Q9ZTC3
Physiology
one SNP in the coding region and several in the putative promoter region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PAP2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Ranson H; Jensen B; Vulule JM ; et al. (2000)
Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]
GP00000818
para
P35500
Physiology
L1014S
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
para (kdr)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998)
Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...]
1 Additional References
GP00000819
para
P35500
Physiology
L1014F
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
para (kdr)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012)
Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]
GP00000820
para
P35500
Physiology
N1575Y
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
para (kdr)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Wang ZM; Li CX ; et al. (2012)
First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]
1 Additional References
GP00000821
para
P35500
Physiology
2 mutations
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Morin S; Williamson MS; Goodson SJ ; et al. (2002)
Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...]
2 Additional References
GP00000822
para
P35500
Physiology
L925I
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
para (kdr)
Bemisia tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Morin S; Williamson MS; Goodson SJ ; et al. (2002)
Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...]
2 Additional References
GP00000823
para
P35500
Physiology
M918V
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
para (kdr)
Bemisia tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Smith TJ; Lee SH; Ingles PJ ; et al. (1997)
The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]
2 Additional References
GP00000824
para
P35500
Physiology
L993F (=L1014F)
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Liu Z; Valles SM; Dong K (2000)
Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...]
2 Additional References
GP00000825
para
P35500
Physiology
C764R (=C785R)
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Liu Z; Valles SM; Dong K (2000)
Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...]
2 Additional References
GP00000826
para
P35500
Physiology
E434K (=E435K)
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
He H; Chen AC; Davey RB ; et al. (1999)
Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...]
1 Additional References
GP00000827
para
P35500
Physiology
F1538I
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
para (kdr)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Chen L; Zhong D; Zhang D ; et al. (2010)
Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.
1 Additional References
GP00000828
para
P35500
Physiology
L1014F
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
para (kdr)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Chen L; Zhong D; Zhang D ; et al. (2010)
Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.
GP00000829
para
P35500
Physiology
L1014S
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
para (kdr)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Cydia pomonella
codling moth - (species) D
Intraspecific
Candidate Gene
Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005)
Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...]
1 Additional References
GP00000830
para
P35500
Physiology
L1014F
Cydia pomonella
codling moth - (species)
Cydia pomonella
codling moth - (species) D
para (kdr)
Cydia pomonella
codling moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep)
Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...]
3 Additional References
GP00000831
para
P35500
Physiology
(=M918T)
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
para (kdr)
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep)
Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...]
1 Additional References
GP00000832
para
P35500
Physiology
L150F (=L1014F)
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
para (kdr)
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Zhao Y; Park Y; Adams ME (2000)
Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...]
3 Additional References
GP00000834
para
P35500
Physiology
V421M (=V410M)
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
para (kdr)
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000835
para
P35500
Physiology
V421M (=V410M)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000836
para
P35500
Physiology
L1029H (= L1014H)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000837
para
P35500
Physiology
V421A (=V410A)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000838
para
P35500
Physiology
V421G (=V410G)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Weston DP; Poynton HC; Wellborn GA ; et al. (2013)
Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]
1 Additional References
GP00000839
para
P35500
Physiology
L925I in species D
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Weston DP; Poynton HC; Wellborn GA ; et al. (2013)
Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]
1 Additional References
GP00000840
para
P35500
Physiology
M918L - ATG>CTG
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Rinkevich FD; Du Y; Dong K (2013)
Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
1 Additional References
GP00000841
para
P35500
Physiology
2 mutations
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
para (kdr)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Linkage Mapping
Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996)
Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...]
2 Additional References
GP00000842
para
P35500
Physiology
L1014F
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Linkage Mapping
Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996)
Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...]
3 Additional References
GP00000843
para
P35500
Physiology
M918T
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Linkage Mapping
Martinez-Torres D; Foster SP; Field LM ; et al. (1999)
A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]
GP00000844
para
P35500
Physiology
L1014F
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004)
High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]
GP00000845
para
P35500
Physiology
(=M918T)
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
3 Mutations:
Coding
SNP
Pediculus humanus
human louse - (species) D
Intraspecific
Candidate Gene
Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010)
Determination of knockdown resistance allele frequencies in global human head louse populations usin[...]
3 Additional References
GP00000846
para
P35500
Physiology
3 mutations
Pediculus humanus
human louse - (species)
Pediculus humanus
human louse - (species) D
para (kdr)
Pediculus humanus
human louse - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Pediculus humanus
human louse - (species) D
Intraspecific
Linkage Mapping
Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000
)
Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]
GP00000847
para
P35500
Physiology
L932F
Pediculus humanus
human louse - (species)
Pediculus humanus
human louse - (species) D
para (kdr)
Pediculus humanus
human louse - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Sonoda S; Igaki C; Tsumuki H (2008)
Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth.
1 Additional References
GP00000848
para
P35500
Physiology
2 mutations
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Linkage Mapping
Usherwood PN; Davies TG; Mellor IR ; et al. (2007)
Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]
GP00000849
para
P35500
Physiology
T929I
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Triatoma infestans
(species)
Intraspecific
Candidate Gene
Fabro J; Sterkel M; Capriotti N ; et al. (2012)
Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]
GP00000850
para
P35500
Physiology
L1014F
Triatoma infestans
(species)
Triatoma infestans
(species)
para (kdr)
Triatoma infestans
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Haddi K; Berger M; Bielza P ; et al. (2012)
Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]
GP00000851
para
P35500
Physiology
M918T
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Haddi K; Berger M; Bielza P ; et al. (2012)
Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]
GP00000852
para
P35500
Physiology
T929I
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Haddi K; Berger M; Bielza P ; et al. (2012)
Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]
GP00000853
para
P35500
Physiology
L1014F
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Wang ZM; Li CX ; et al. (2012)
First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]
1 Additional References
GP00001689
para
P35500
Physiology
L1014F; Haplotype H02
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species)
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001691
para
P35500
Physiology
L1014S; Haplotype H04
Anopheles sinensis
(species)
Anopheles sinensis
(species)
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles vagus
(species) D
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001692
para
P35500
Physiology
L1014S
Anopheles vagus
(species)
Anopheles vagus
(species) D
para (kdr)
Anopheles vagus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001695
para
P35500
Physiology
L1014S
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles paraliae
(species)
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001696
para
P35500
Physiology
L1014S
Anopheles paraliae
(species)
Anopheles paraliae
(species)
para (kdr)
Anopheles paraliae
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Wang ZM; Li CX ; et al. (2012)
First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]
1 Additional References
GP00001699
para
P35500
Physiology
L1014F; Haplotype H04
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Cimex lectularius
bed bug - (species) D
Intraspecific
Candidate Gene
Yoon KS; Kwon DH; Strycharz JP ; et al. (2008)
Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...]
4 Additional References
GP00001859
para
P35500
Physiology
2 mutations
Cimex lectularius
bed bug - (species)
Cimex lectularius
bed bug - (species) D
para (kdr)
Cimex lectularius
bed bug - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
González-Cabrera J; Davies TG; Field LM ; et al. (2013)
An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor.
1 Additional References
GP00001860
para
P35500
Physiology
L925V
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Intraspecific
Candidate Gene
Karatolos N; Gorman K; Williamson MS ; et al. (2012)
Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...]
1 Additional References
GP00001861
para
P35500
Physiology
M918L - found in samples from China and Europe
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
para (kdr)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Intraspecific
Candidate Gene
Karatolos N; Gorman K; Williamson MS ; et al. (2012)
Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...]
1 Additional References
GP00001862
para
P35500
Physiology
2 mutations
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
para (kdr)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species)
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00001863
para
P35500
Physiology
M918L - ATG>TTG - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).
Hyalella azteca
(species)
Hyalella azteca
(species)
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00001864
para
P35500
Physiology
L925V
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Panini M; Anaclerio M; Puggioni V ; et al. (2015)
Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...]
3 Additional References
GP00001865
para
P35500
Physiology
M918L
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Panini M; Anaclerio M; Puggioni V ; et al. (2015)
Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...]
1 Additional References
GP00001866
para
P35500
Physiology
M918L
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Ishak IH; Jaal Z; Ranson H ; et al. (2015)
Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...]
2 Additional References
GP00002444
para
P35500
Physiology
V1016G
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Ishak IH; Jaal Z; Ranson H ; et al. (2015)
Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...]
1 Additional References
GP00002445
para
P35500
Physiology
F1534C
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
3 Mutations:
Coding
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Plernsub S; Saingamsook J; Yanola J ; et al. (2016)
Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...]
1 Additional References
GP00002446
para
P35500
Physiology
3 mutations
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Kasai S; Ng LC; Lam-Phua SG ; et al. (2011)
First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus.
1 Additional References
GP00002447
para
P35500
Physiology
F1534C
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
para (kdr)
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Phlebotomus argentipes
(species) D
Intraspecific
Candidate Gene
Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021)
Chemical control and insecticide resistance status of sand fly vectors worldwide.
GP00002469
para
P35500
Physiology
L1014S
Phlebotomus argentipes
(species)
Phlebotomus argentipes
(species) D
para (kdr)
Phlebotomus argentipes
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Phlebotomus argentipes
(species) D
Intraspecific
Candidate Gene
Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021)
Chemical control and insecticide resistance status of sand fly vectors worldwide.
GP00002470
para
P35500
Physiology
L1014F
Phlebotomus argentipes
(species)
Phlebotomus argentipes
(species) D
para (kdr)
Phlebotomus argentipes
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Candidate Gene
Head DJ; McCaffery AR; Callaghan A (1998)
Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]
GP00002486
para
P35500
Physiology
2 mutations
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
para (kdr)
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Head DJ; McCaffery AR; Callaghan A (1998)
Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]
GP00002487
para
P35500
Physiology
2 mutations
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
para (kdr)
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Haddi K; Tomé HVV; Du Y ; et al. (2017)
Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...]
1 Additional References
GP00002488
para
P35500
Physiology
2 mutations
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Xu Q; Zhang L; Li T ; et al. (2012)
Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following i[...]
GP00002489
para
P35500
Physiology
3 nonsynonymous A(109)S L(982)F and W(1573)R) and 6 synonymous L(852) G(891) A(1241) D(1245) P(1249) and G(1733)) mutations were identified. The co-existence of all 9 mutations and their homozygousity were found to be important factors for high levels of resistance.
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
para (kdr)
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Marshall Kate L; Moran Christopher; Chen Yizhou ; et al. (2012
)
Detection of kdr pyrethroid resistance in the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), u[...]
2 Additional References
GP00002490
para
P35500
Physiology
L1014F
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
para (kdr)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus evansi
red spider mite - (species) D
Intraspecific
Linkage Mapping
Nyoni BN; Gorman K; Mzilahowa T ; et al. (2011)
Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation[...]
GP00002493
para
P35500
Physiology
M918T - first report of the M918T mutation in the absence of L1014F in any arthropod species.
Tetranychus evansi
red spider mite - (species)
Tetranychus evansi
red spider mite - (species) D
para (kdr)
Tetranychus evansi
red spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Liriomyza huidobrensis
pea leafminer - (species) D
Intraspecific
Candidate Gene
Davies TG; Field LM; Usherwood PN ; et al. (2007)
DDT, pyrethrins, pyrethroids and insect sodium channels.
GP00002494
para
P35500
Physiology
2 mutations
Liriomyza huidobrensis
pea leafminer - (species)
Liriomyza huidobrensis
pea leafminer - (species) D
para (kdr)
Liriomyza huidobrensis
pea leafminer - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Liriomyza sativae
vegetable leafminer - (species) D
Intraspecific
Candidate Gene
Davies TG; Field LM; Usherwood PN ; et al. (2007)
DDT, pyrethrins, pyrethroids and insect sodium channels.
GP00002495
para
P35500
Physiology
L1014F
Liriomyza sativae
vegetable leafminer - (species)
Liriomyza sativae
vegetable leafminer - (species) D
para (kdr)
Liriomyza sativae
vegetable leafminer - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Thrips tabaci
(species) D
Intraspecific
Candidate Gene
Toda S; Morishita M (2009)
Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]
GP00002496
para
P35500
Physiology
2 mutations
Thrips tabaci
(species)
Thrips tabaci
(species) D
para (kdr)
Thrips tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Thrips tabaci
(species) D
Intraspecific
Candidate Gene
Toda S; Morishita M (2009)
Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]
GP00002497
para
P35500
Physiology
T929I
Thrips tabaci
(species)
Thrips tabaci
(species) D
para (kdr)
Thrips tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Carletto J; Martin T; Vanlerberghe-Masutti F ; et al. (2010)
Insecticide resistance traits differ among and within host races in Aphis gossypii.
GP00002498
para
P35500
Physiology
M918L
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
para (kdr)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00002499
para
P35500
Physiology
M918L in species B
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00002500
para
P35500
Physiology
M918L in species C
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Thrips tabaci
(species) D
Intraspecific
Candidate Gene
Wu M; Gotoh H; Waters T ; et al. (2014)
Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...]
1 Additional References
GP00002501
para
P35500
Physiology
2 mutations
Thrips tabaci
(species)
Thrips tabaci
(species) D
para (kdr)
Thrips tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
Morgan JA; Corley SW; Jackson LA ; et al. (2009)
Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boop[...]
1 Additional References
GP00002502
para
P35500
Physiology
L925I - Cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216 results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly Bemisia tabaci.
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
para (kdr)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Thrips palmi
(species) D
Intraspecific
Candidate Gene
Bao Wen Xue; Sonoda Shoji (2012
)
Resistance to cypermethrin in melon thrips, Thrips palmi (Thysanoptera: Thripidae), is conferred by [...]
GP00002503
para
P35500
Physiology
T929I
Thrips palmi
(species)
Thrips palmi
(species) D
para (kdr)
Thrips palmi
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Rinkevich FD; Du Y; Dong K (2013)
Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
1 Additional References
GP00002504
para
P35500
Physiology
T929I
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
para (kdr)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitophilus zeamais
maize weevil - (species) D
Intraspecific
Candidate Gene
Araújo RA; Williamson MS; Bass C ; et al. (2011)
Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gat[...]
1 Additional References
GP00002505
para
P35500
Physiology
T929I
Sitophilus zeamais
maize weevil - (species)
Sitophilus zeamais
maize weevil - (species) D
para (kdr)
Sitophilus zeamais
maize weevil - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002506
para
P35500
Physiology
T929V
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002507
para
P35500
Physiology
T929C
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002508
para
P35500
Physiology
T929I
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002509
para
P35500
Physiology
L1014F
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Linkage Mapping
Endersby NM; Viduka K; Baxter SW ; et al. (2011)
Widespread pyrethroid resistance in Australian diamondback moth, Plutella xylostella (L.), is relate[...]
1 Additional References
GP00002510
para
P35500
Physiology
F1020S
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Mavridis K; Papapostolou KM; Ilias A ; et al. (2022)
Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]
2 Additional References
GP00002511
para
P35500
Physiology
T929V
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
para (kdr)
Bemisia tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Ctenocephalides felis
cat flea - (species) D
Intraspecific
Candidate Gene
Bass C; Schroeder I; Turberg A ; et al. (2004)
Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...]
1 Additional References
GP00002514
para
P35500
Physiology
T929V
Ctenocephalides felis
cat flea - (species)
Ctenocephalides felis
cat flea - (species) D
para (kdr)
Ctenocephalides felis
cat flea - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Ctenocephalides felis
cat flea - (species) D
Intraspecific
Candidate Gene
Bass C; Schroeder I; Turberg A ; et al. (2004)
Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...]
1 Additional References
GP00002515
para
P35500
Physiology
L1014F
Ctenocephalides felis
cat flea - (species)
Ctenocephalides felis
cat flea - (species) D
para (kdr)
Ctenocephalides felis
cat flea - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
Jonsson NN; Cutullè C; Corley SW ; et al. (2010)
Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus microp[...]
2 Additional References
GP00002516
para
P35500
Physiology
G72V = G933V - G toT non-synonymous mutation at nucleotide position 214 that results in a glycine to valine substitution (G72V)
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
para (kdr)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
1 Additional References
GP00002517
para
P35500
Physiology
I951V = I936V
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Lepeophtheirus salmonis
salmon louse - (species) D
Intraspecific
Candidate Gene
Fallang A; Denholm I; Horsberg TE ; et al. (2005)
Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice Lepeophtheirus salm[...]
1 Additional References
GP00002518
para
P35500
Physiology
Q945R in transmembrane segment IIS5
Lepeophtheirus salmonis
salmon louse - (species)
Lepeophtheirus salmonis
salmon louse - (species) D
para (kdr)
Lepeophtheirus salmonis
salmon louse - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Brengues C; Hawkes NJ; Chandre F ; et al. (2003)
Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...]
1 Additional References
GP00002519
para
P35500
Physiology
I104M = I1011M
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Saavedra-Rodriguez K; Urdaneta-Marquez L; Rajatileka S ; et al. (2007)
A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin A[...]
1 Additional References
GP00002520
para
P35500
Physiology
I1011V
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles stephensi
Asian malaria mosquito - (species) D
Intraspecific
Candidate Gene
Enayati AA; Vatandoost H; Ladonni H ; et al. (2003)
Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Ano[...]
2 Additional References
GP00002521
para
P35500
Physiology
L1014F - one point mutation difference involving a single A-T base change encoding a leucine to phenylalanine amino acid substitution in the pyrethroid-resistant strain.
Anopheles stephensi
Asian malaria mosquito - (species)
Anopheles stephensi
Asian malaria mosquito - (species) D
para (kdr)
Anopheles stephensi
Asian malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles stephensi
Asian malaria mosquito - (species) D
Intraspecific
Candidate Gene
Safi NHZ; Ahmadi AA; Nahzat S ; et al. (2019)
Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]
GP00002522
para
P35500
Physiology
L1014S
Anopheles stephensi
Asian malaria mosquito - (species)
Anopheles stephensi
Asian malaria mosquito - (species) D
para (kdr)
Anopheles stephensi
Asian malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles subpictus
(species) D
Intraspecific
Candidate Gene
Karunaratne SHPP; Hawkes Nicola J; Perera MDB ; et al. (2007
)
Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populatio[...]
1 Additional References
GP00002523
para
P35500
Physiology
L1014F - TTA>TTT
Anopheles subpictus
(species)
Anopheles subpictus
(species) D
para (kdr)
Anopheles subpictus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Xu Q; Liu H; Zhang L ; et al. (2005)
Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance.
1 Additional References
GP00002524
para
P35500
Physiology
L1014F
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
para (kdr)
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
D
Intraspecific
Candidate Gene
Rothwell JT; Morgan JA; James PJ ; et al. (2011)
Mechanism of resistance to synthetic pyrethroids in buffalo flies in south-east Queensland.
1 Additional References
GP00002525
para
P35500
Physiology
L1014F
D
para (kdr)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Brassicogethes aeneus
(species)
Intraspecific
Candidate Gene
Nauen Ralf; Zimmer Christoph T; Andrews Melanie ; et al. (2012
)
Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F.[...]
1 Additional References
GP00002526
para
P35500
Physiology
L1014F - found in individuals from Denmark and Sweden
Brassicogethes aeneus
(species)
Brassicogethes aeneus
(species)
para (kdr)
Brassicogethes aeneus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitobion avenae
English grain aphid - (species) D
Intraspecific
Candidate Gene
Foster SP; Paul VL; Slater R ; et al. (2014)
A mutation (L1014F) in the voltage-gated sodium channel of the grain aphid, Sitobion avenae, is asso[...]
1 Additional References
GP00002527
para
P35500
Physiology
L1014F
Sitobion avenae
English grain aphid - (species)
Sitobion avenae
English grain aphid - (species) D
para (kdr)
Sitobion avenae
English grain aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Cassanelli S; Cerchiari B; Giannini S ; et al. (2005)
Use of the RFLP-PCR diagnostic test for characterizing MACE and kdr insecticide resistance in the pe[...]
1 Additional References
GP00002528
para
P35500
Physiology
F979S (housefly numbering) located inside the linker segment IIS5-6
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles arabiensis
(species)
Intraspecific
Candidate Gene
Stump AD; Atieli FK; Vulule JM ; et al. (2004)
Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles ga[...]
1 Additional References
GP00002529
para
P35500
Physiology
L1014S
Anopheles arabiensis
(species)
Anopheles arabiensis
(species)
para (kdr)
Anopheles arabiensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles culicifacies
(species) D
Intraspecific
Candidate Gene
Singh OP; Dykes CL; Das MK ; et al. (2010)
Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in [...]
GP00002530
para
P35500
Physiology
L1014S
Anopheles culicifacies
(species)
Anopheles culicifacies
(species) D
para (kdr)
Anopheles culicifacies
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles culicifacies
(species) D
Intraspecific
Candidate Gene
Singh OP; Bali P; Hemingway J ; et al. (2009)
PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato.
GP00002531
para
P35500
Physiology
L1014F
Anopheles culicifacies
(species)
Anopheles culicifacies
(species) D
para (kdr)
Anopheles culicifacies
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sacharovi
(species)
Intraspecific
Candidate Gene
Lüleyap HU; Alptekin D; Kasap H ; et al. (2002)
Detection of knockdown resistance mutations in Anopheles sacharovi (Diptera: Culicidae) and genetic [...]
2 Additional References
GP00002532
para
P35500
Physiology
L1014S
Anopheles sacharovi
(species)
Anopheles sacharovi
(species)
para (kdr)
Anopheles sacharovi
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sacharovi
(species)
Intraspecific
Candidate Gene
Yavaşoglu Sİ; Ülger C; Şimşek FM (2021)
The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...]
1 Additional References
GP00002533
para
P35500
Physiology
L1014F
Anopheles sacharovi
(species)
Anopheles sacharovi
(species)
para (kdr)
Anopheles sacharovi
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Stomoxys calcitrans
stable fly - (species) D
Intraspecific
Candidate Gene
Olafson PU; Pitzer JB; Kaufman PE (2011)
Identification of a mutation associated with permethrin resistance in the para-type sodium channel o[...]
2 Additional References
GP00002534
para
P35500
Physiology
L1014H
Stomoxys calcitrans
stable fly - (species)
Stomoxys calcitrans
stable fly - (species) D
para (kdr)
Stomoxys calcitrans
stable fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Kang S; Jung J; Lee S ; et al. (2012)
The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles si[...]
1 Additional References
GP00002536
para
P35500
Physiology
L1014C
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles albimanus
(species) D
Intraspecific
Candidate Gene
Lol JC; Castellanos ME; Liebman KA ; et al. (2013)
Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...]
1 Additional References
GP00002537
para
P35500
Physiology
L1014C in Nicaragua and Costa Rica individuals
Anopheles albimanus
(species)
Anopheles albimanus
(species) D
para (kdr)
Anopheles albimanus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles albimanus
(species) D
Intraspecific
Candidate Gene
Lol JC; Castellanos ME; Liebman KA ; et al. (2013)
Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...]
1 Additional References
GP00002538
para
P35500
Physiology
L1014F in Mexico individuals
Anopheles albimanus
(species)
Anopheles albimanus
(species) D
para (kdr)
Anopheles albimanus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Wang ZM; Li CX; Xing D ; et al. (2012)
Detection and widespread distribution of sodium channel alleles characteristic of insecticide resist[...]
1 Additional References
GP00002539
para
P35500
Physiology
L1014C
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
para (kdr)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Li CX; Wang ZM ; et al. (2012)
First detection of multiple knockdown resistance (kdr)-like mutations in voltage-gated sodium channe[...]
1 Additional References
GP00002540
para
P35500
Physiology
L1014W
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Pridgeon Julia W; Appel Arthur G; Moar William J ; et al. (2002
)
Variability of resistance mechanisms in pyrethroid resistant German cockroaches (Dictyoptera: Blatte[...]
1 Additional References
GP00002541
para
P35500
Physiology
F999S = F1020S - T to C at nt 2996 resulting in a phenylalanine999 to serine999 amino acid change
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Kwon Deok Ho; Clark J Marshall; Lee Si Hyeock (2010
)
Cloning of a sodium channel gene and identification of mutations putatively associated with fenpropa[...]
1 Additional References
GP00002542
para
P35500
Physiology
L1024V
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
para (kdr)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997)
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...]
1 Additional References
GP00002543
para
P35500
Physiology
A1549V = A1410V
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
para (kdr)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997)
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...]
1 Additional References
GP00002544
para
P35500
Physiology
A1648V = A1494V
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
para (kdr)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Kawada H; Higa Y; Komagata O ; et al. (2009)
Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroi[...]
1 Additional References
GP00002545
para
P35500
Physiology
F1269C = F1534C
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus cinnabarinus
carmine spider mite - (species) D
Intraspecific
Candidate Gene
Feng YN; Zhao S; Sun W ; et al. (2011)
The sodium channel gene in Tetranychus cinnabarinus (Boisduval): identification and expression analy[...]
1 Additional References
GP00002546
para
P35500
Physiology
F1538I
Tetranychus cinnabarinus
carmine spider mite - (species)
Tetranychus cinnabarinus
carmine spider mite - (species) D
para (kdr)
Tetranychus cinnabarinus
carmine spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Tsagkarakou A; Van Leeuwen T; Khajehali J ; et al. (2009)
Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-s[...]
1 Additional References
GP00002547
para
P35500
Physiology
F1538I
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
para (kdr)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997)
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...]
1 Additional References
GP00002548
para
P35500
Physiology
M1524I
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
para (kdr)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
Hubert J; Nesvorna M; Kamler M ; et al. (2014)
Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]
GP00002549
para
P35500
Physiology
F975L
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002
)
Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]
1 Additional References
GP00002550
para
P35500
Physiology
F1528L+M1823I
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002
)
Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]
GP00002551
para
P35500
Physiology
F758L+L826P+I982V+M1055I = F1528L+L1596P+I1752V+M1823I
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Stomoxys calcitrans
stable fly - (species) D
Intraspecific
Candidate Gene
Olafson PU; Kaufman PE; Duvallet G ; et al. (2019)
Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]
GP00002613
para
P35500
Physiology
L1014F
Stomoxys calcitrans
stable fly - (species)
Stomoxys calcitrans
stable fly - (species) D
para (kdr)
Stomoxys calcitrans
stable fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021)
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]
1 Additional References
GP00002614
para
P35500
Physiology
M918I ATG>ATT
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021)
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]
1 Additional References
GP00002615
para
P35500
Physiology
M918I ATG>ATA
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Kushwah RBS; Kaur T; Dykes CL ; et al. (2020)
A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegy[...]
GP00002625
para
P35500
Physiology
F1534L - Phe (TTC) > Leu (CTC)
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang XL; Su W; Zhang JH ; et al. (2016)
Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...]
1 Additional References
GP00002629
para
P35500
Physiology
F1845Y
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang XL; Su W; Zhang JH ; et al. (2016)
Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...]
1 Additional References
GP00002630
para
P35500
Physiology
V1848I
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Mavridis K; Riga M ; et al. (2017)
Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...]
1 Additional References
GP00002631
para
P35500
Physiology
V1848I
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Mavridis K; Riga M ; et al. (2017)
Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...]
1 Additional References
GP00002632
para
P35500
Physiology
F1845Y
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Sun H; Kasai S; Scott JG (2017)
Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]
GP00002644
para
P35500
Physiology
super-kdr+D600N - super-kdr+D600N confers higher levels of resistance to seven pyrethroids relative to super-kdr.
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Sun H; Kasai S; Scott JG (2017)
Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]
GP00002645
para
P35500
Physiology
kdr+T929I - addition of T929I to the kdr mutation (L1014F) increased resistance to all pyrethroids (except etofenprox) and enhanced resistance by ~1000-fold to acrinathrin and flumethrin.
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Wu Y; Liu Q; Qi Y ; et al. (2021)
Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]
GP00002646
para
P35500
Physiology
F1534S
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
para (kdr)
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Wu Y; Liu Q; Qi Y ; et al. (2021)
Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]
GP00002647
para
P35500
Physiology
I1532T
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
para (kdr)
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Fontaine S; Caddoux L; Brazier C ; et al. (2011)
Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...]
1 Additional References
GP00002649
para
P35500
Physiology
L932F
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
pastrel
Pathogen resistance (viruses)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Magwire MM; Fabian DK; Schweyen H ; et al. (2012)
Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving [...]
GP00000854
pst
Q8IQ82
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
pastrel
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
peel-1
Hybrid incompatibility
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Seidel HS; Ailion M; Li J ; et al. (2011)
A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]
1 Additional References
GP00001321
peel-1
G5EGC6
Physiology
1bp deletion creating a frameshift starting at amino acid position 43. Total length of wild-type protein is 174 amino acids. N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
peel-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
peel-1
Hybrid incompatibility
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Seidel HS; Ailion M; Li J ; et al. (2011)
A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]
1 Additional References
GP00001322
peel-1
G5EGC6
Physiology
G>T - glycine to stop codon at position 57. Total length of wild-type protein is 174 amino acids. N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
peel-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
peel-1/zeel-1
Hybrid incompatibility
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Seidel HS; Rockman MV; Kruglyak L (2008)
Widespread genetic incompatibility in C. elegans maintained by balancing selection.
1 Additional References
GP00001320
peel-1
G5EGC6
Physiology
19kb deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
peel-1/zeel-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
pepsinogen A
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001911
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
pepsinogen A
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001917
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A1
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001924
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A1
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A1
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001930
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A1
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001918
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Oreochromis niloticus
Nile tilapia - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A2
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001925
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A2
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A2
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001931
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A2
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Danio rerio
zebrafish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001919
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Gadus morhua
Atlantic cod - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Danio rerio
zebrafish - (species) D
pepsinogen A3
Danio rerio
zebrafish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001926
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A3
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001927
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Oryzias latipes
Japanese medaka - (species) D
Xiphophorus maculatus
southern platyfish - (species) D
pepsinogen A3
Oryzias latipes
Japanese medaka - (species)
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
pepsinogen A3
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
Intergeneric or Higher
Candidate Gene
Castro LF; Gonçalves O; Mazan S ; et al. (2014)
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.
GP00001932
PGA4
P0DJD7
Physiology
Absence of the gene in the genome sequence - high synteny N
Oreochromis niloticus
Nile tilapia - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Takifugu rubripes
torafugu - (species) D
Tetraodon nigroviridis
spotted green pufferfish - (species) D
pepsinogen A3
Takifugu rubripes
torafugu - (species)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
pepsinogen B
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001913
PGB
Q8SQ41
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
pepsinogen B
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
pepsinogen C
Digestion (absence of stomach)
Gene Loss,
Deletion
N
Ornithorhynchus anatinus
platypus - (species) D
Intergeneric or Higher
Candidate Gene
Ordoñez GR; Hillier LW; Warren WC ; et al. (2008)
Loss of genes implicated in gastric function during platypus evolution.
GP00001912
PGC
P20142
Physiology
Absence of the gene in the genome sequence - high synteny N
Monodelphis domestica
gray short-tailed opossum - (species)
Ornithorhynchus anatinus
platypus - (species) D
pepsinogen C
Ornithorhynchus anatinus
platypus - (species)
Published - Accepted by Curator
PEPT1
Anti-freezing
Coding,
Unknown
Chionodraco hamatus
Antarctic icefish - (species)
Intergeneric or Higher
Candidate Gene
Rizzello A; Romano A; Kottra G ; et al. (2013)
Protein cold adaptation strategy via a unique seven-amino acid domain in the icefish (Chionodraco ha[...]
GP00000858
slc15a1
Q804I3
Physiology
C-terminal (cytosolic) de novo VDMSRKS domain conferring cold resistance
Teleostei
teleost fishes - (infraclass)
Chionodraco hamatus
Antarctic icefish - (species)
PEPT1
Chionodraco hamatus
Antarctic icefish - (species)
Published - Accepted by Curator
PER36
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Macquet A; Ralet MC; Loudet O ; et al. (2007)
A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...]
1 Additional References
GP00001273
PER36
Q9SD46
Physiology
Tyrosine @position 262bp to a stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PER36
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Period (per)
Diapause
Unknown,
Unknown
Pieris napi
(species)
Intraspecific
Association Mapping
Pruisscher P; Nylin S; Wheat CW ; et al. (2021)
A region of the sex chromosome associated with population differences in diapause induction contains[...]
1 Additional References
GP00002427
per
P07663
Physiology
Multiple amino acid differences. Presence of five fixed SNPs between the N and S populations (one intergenic, two intronic and two exonic nonsynonymous substitutions).
Pieris napi
(species)
Pieris napi
(species)
Period (per)
Pieris napi
(species)
Published - Accepted by Curator
PG
Fruit ripening
Coding,
Deletion
N
Capsicum annuum
(species) D
Domesticated
Candidate Gene
Kim S; Park M; Yeom SI ; et al. (2014)
Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]
GP00001448
PG
B9VRK6
Physiology
a partial deletion of about 90aa in the C-terminal region N
Solanum lycopersicum
tomato - (species)
Capsicum annuum
(species) D
PG
Capsicum annuum
(species)
Published - Accepted by Curator
PG
Fruit ripening
Coding,
SNP
N
Capsicum chinense
(species) D
Domesticated
Candidate Gene
Kim S; Park M; Yeom SI ; et al. (2014)
Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum speci[...]
GP00001449
PG
B9VRK6
Physiology
a point mutation in the 3' splice acceptor site of intron VIII generates a premature stop codon N
Solanum lycopersicum
tomato - (species)
Capsicum chinense
(species) D
PG
Capsicum chinense
(species)
Published - Accepted by Curator
PGRP-LC
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sackton TB; Lazzaro BP; Clark AG (2010)
Genotype and gene expression associations with immune function in Drosophila.
GP00000861
PGRP-LC
Q9GNK5
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
PGRP-LC
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
PHGPx
Xenobiotic resistance (gemcitabine ; female fertility)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
King EG; Kislukhin G; Walters KN ; et al. (2014)
Using Drosophila melanogaster to identify chemotherapy toxicity genes.
GP00001405
PHGPx
Q8IRD4
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
PHGPx
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
PHO5
Low-phosphate adaptation (experimental evolution)
Gene Amplification,
Deletion
Saccharomyces cerevisiae
baker's yeast - (species)
Experimental Evolution
Association Mapping
Gresham D; Desai MM; Tucker CM ; et al. (2008)
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]
GP00000863
PHO5
P00635
Physiology
Deletion. Out of 8 lines; 2 distinct lines evolved structural variation at PHO5. (Interestingly; one was a deletion and another one was a gene amplification)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
PHO5
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PHO5
Low-phosphate adaptation (experimental evolution)
Gene Amplification,
Insertion
Saccharomyces cerevisiae
baker's yeast - (species)
Experimental Evolution
Association Mapping
Gresham D; Desai MM; Tucker CM ; et al. (2008)
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]
GP00000864
PHO5
P00635
Physiology
Gene duplication. Out of 8 lines; 2 distinct lines evolved structural variation at PHO5. (Interestingly; one was a deletion and another one was a gene amplification)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
PHO5
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PHO84
Xenobiotic resistance
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Perlstein EO; Ruderfer DM; Roberts DC ; et al. (2007)
Genetic basis of individual differences in the response to small-molecule drugs in yeast.
GP00000865
PHO84
P25297
Physiology
L259P
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
PHO84
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)
C3-C4 photosynthesis (enzymatic properties)
Coding,
SNP
Alloteropsis
(genus)
Interspecific
Candidate Gene
Christin PA; Edwards EJ; Besnard G ; et al. (2012)
Adaptive evolution of C(4) photosynthesis through recurrent lateral gene transfer.
GP00000866
PPCA
P30694
Physiology
Haplotype of several candidate a.a. ; lateral gene transfer between convergent C4 species
Alloteropsis
(genus)
Alloteropsis
(genus)
phosphoenolpyruvate carboxylase (PEPC)
Alloteropsis
(genus)
Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)
C3-C4 photosynthesis (enzymatic properties)
2 Mutations:
Coding
SNP
N
Flaveria trinervia
(species)
Interspecific
Candidate Gene
Bläsing OE; Westhoff P; Svensson P (2000)
Evolution of C4 phosphoenolpyruvate carboxylase in Flaveria, a conserved serine residue in the carbo[...]
1 Additional References
GP00000867
PPCA
P30694
Physiology
2 mutations
Flaveria pringlei
(species)
Flaveria trinervia
(species)
phosphoenolpyruvate carboxylase (PEPC)
Flaveria trinervia
(species)
Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)
C3-C4 photosynthesis (enzymatic properties)
Cis-regulatory,
Insertion
Flaveria trinervia
(species) D
Interspecific
Candidate Gene
Akyildiz M; Gowik U; Engelmann S ; et al. (2007)
Evolution and function of a cis-regulatory module for mesophyll-specific gene expression in the C4 d[...]
GP00000868
PPCA
P30694
Physiology
insertion of tetranucleotide CACT
Flaveria pringlei
(species)
Flaveria trinervia
(species) D
phosphoenolpyruvate carboxylase (PEPC)
Flaveria trinervia
(species)
Published - Accepted by Curator
phosphoenolpyruvate carboxylase (PEPC)
C3-C4 photosynthesis (enzymatic properties)
Cis-regulatory,
SNP
Flaveria trinervia
(species)
Interspecific
Candidate Gene
Akyildiz M; Gowik U; Engelmann S ; et al. (2007)
Evolution and function of a cis-regulatory module for mesophyll-specific gene expression in the C4 d[...]
GP00000869
PPCA
P30694
Physiology
G->A
Flaveria pringlei
(species)
Flaveria trinervia
(species)
phosphoenolpyruvate carboxylase (PEPC)
Flaveria trinervia
(species)
Published - Accepted by Curator
phytochrome A (PHYA)
Light sensitivity
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Maloof JN; Borevitz JO; Dabi T ; et al. (2001)
Natural variation in light sensitivity of Arabidopsis.
GP00000870
PHYA
P14712
Physiology
M548T
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
phytochrome A (PHYA)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome A (PHYA)
Light sensitivity
High-altitude adaptation
Coding,
Insertion
N
Glycine max
soybean - (species) D
Domesticated
Candidate Gene
Liu B; Kanazawa A; Matsumura H ; et al. (2008)
Genetic redundancy in soybean photoresponses associated with duplication of the phytochrome A gene.
1 Additional References
GP00002104
PHYA
P14712
Physiology
Physiology
insertion of a retrotransposon in exon 1 - The transposable element is SORE-1 = a novel Ty1/copia-like retrotransposon in soybean N
Glycine max
soybean - (species)
Glycine max
soybean - (species) D
phytochrome A (PHYA)
Glycine max
soybean - (species)
Published - Accepted by Curator
phytochrome A-associated F-box protein
Circadian rhythm (phase)
Coding,
Deletion
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Müller NA; Wijnen CL; Srinivasan A ; et al. (2016)
Domestication selected for deceleration of the circadian clock in cultivated tomato.
GP00001287
101247753
K4CV85
Physiology
3bp deletion in CDS causing a 'K (lysine) loss in the highly conserved C terminus of EID1
Solanum pimpinellifolium
(species)
Solanum lycopersicum
tomato - (species) D
phytochrome A-associated F-box protein
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
phytochrome B (PHYB)
Light sensitivity
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Filiault DL; Wessinger CA; Dinneny JR ; et al. (2008)
Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.
GP00000871
PHYB
P14713
Physiology
I143L
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
phytochrome B (PHYB)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome B (PHYB)
Light sensitivity
Coding,
Deletion
Sorghum bicolor
sorghum - (species) D
Domesticated
Linkage Mapping
Childs KL; Miller FR; Cordonnier-Pratt MM ; et al. (1997)
The sorghum photoperiod sensitivity gene, Ma3, encodes a phytochrome B.
GP00000872
PHYB
P14713
Physiology
1bp deletion 30bp upstream of the stop codon
Sorghum bicolor
sorghum - (species)
Sorghum bicolor
sorghum - (species) D
phytochrome B (PHYB)
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
phytochrome C (PHYC)
Light sensitivity
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006)
The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]
GP00000873
PHYC
P14714
Physiology
K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
phytochrome C (PHYC)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome D (PHYD)
Leaf morphology (increased petiole length)
Cotyledon morphology (reduced cotyledon area)
Coloration (anthocyanin accumulation in seedling stems)
Plant size (diminished effect of end-of-day pulse of far red light on hypocotyl elongation)
Plant architecture (decrease in number of rosette leaves at onset of flowering)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Aukerman MJ; Hirschfeld M; Wester L ; et al. (1997)
A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome [...]
GP00000874
PHYD
P42497
Morphology
Morphology
Morphology
Physiology
Morphology
14bp deletion causing premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
phytochrome D (PHYD)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytoene synthase
Carotenoid content (seed)
Unknown,
Unknown
Zea mays
(species)
Domesticated
Linkage Mapping
Palaisa KA; Morgante M; Williams M ; et al. (2003)
Contrasting effects of selection on sequence diversity and linkage disequilibrium at two phytoene sy[...]
1 Additional References
GP00000875
PSY1
P49085
Physiology
Not identified
Zea mays
(species)
Zea mays
(species)
phytoene synthase
Zea mays
(species)
Published - Accepted by Curator
phytoene synthase
Carotenoid content (fruit)
Coding,
Insertion
N
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Fray RG; Grierson D (1993)
Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequen[...]
1 Additional References
GP00001718
PSY1
P49085
Physiology
insertion of a Rider transposable element within the coding region N
Solanum lycopersicum
tomato - (species)
Solanum lycopersicum
tomato - (species) D
phytoene synthase
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
phytoene synthase
Carotenoid content (fruit)
Coding,
Indel
N
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Fray RG; Grierson D (1993)
Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequen[...]
1 Additional References
GP00001719
PSY1
P49085
Physiology
r y cDNA was found to be mutated at its 3' end, lacking the last 237 bases of PSY1 coding sequence and containing 185 nucleotides of an unrelated sequence in its place N
Solanum lycopersicum
tomato - (species)
Solanum lycopersicum
tomato - (species) D
phytoene synthase
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
Pi-ta
Pathogen resistance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Bryan GT; Wu KS; Farrall L ; et al. (2000)
tA single amino acid difference distinguishes resistant and susceptible alleles of the rice blast re[...]
2 Additional References
GP00000876
Pi-ta
C9E6G5
Physiology
Ala918Ser
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pi-ta
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pi2 (Nbs4-Pi2)
Pathogen resistance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Zhou B; Qu S; Liu G ; et al. (2006)
The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance [...]
GP00000877
PI2
M1EC06
Physiology
eight amino acid changes - exact causing change(s) unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pi2 (Nbs4-Pi2)
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pi36
Pathogen resistance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Liu X; Lin F; Wang L ; et al. (2007)
The in silico map-based cloning of Pi36, a rice coiled-coil nucleotide-binding site leucine-rich rep[...]
GP00000878
Pi36
D5J6W0
Physiology
Asp590Ser
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pi36
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pi37
Pathogen resistance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Lin F; Chen S; Que Z ; et al. (2007)
The blast resistance gene Pi37 encodes a nucleotide binding site leucine-rich repeat protein and is [...]
GP00000879
Pi37
Q06AJ9
Physiology
V239A and I247M are the only amino acid substitutions found in all tested resistant strains- the effect of each individual amino acid change has not been tested
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pi37
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pi5-1 + Pi5-2 cluster
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Lee SK; Song MY; Seo YS ; et al. (2009)
Rice Pi5-mediated resistance to Magnaporthe oryzae requires the presence of two coiled-coil-nucleoti[...]
GP00000880
Pi5-1
C3SBK3
Physiology
In genetic transformation experiments of a susceptible rice cultivar neither the Pi5-1 nor the Pi5-2 gene was found to confer resistance to M. oryzae. In contrast transgenic rice plants expressing both of these genes (generated by crossing transgenic lines carrying each gene individually) conferred Pi5-mediated resistance to M. oryzae
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pi5-1 + Pi5-2 cluster
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pi9 (= Nbs2-Pi9)
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Qu S; Liu G; Zhou B ; et al. (2006)
The broad-spectrum blast resistance gene Pi9 encodes a nucleotide-binding site-leucine-rich repeat p[...]
GP00000881
Pi9
Q1WGB0
Physiology
Coding variation; necessary for resistance in completementation assay
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pi9 (= Nbs2-Pi9)
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pib
Pathogen resistance
Unknown,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Wang ZX; Yano M; Yamanouchi U ; et al. (1999)
The Pib gene for rice blast resistance belongs to the nucleotide binding and leucine-rich repeat cla[...]
GP00000882
Pi-b
Q9SSY0
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pib
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pid3
Pathogen resistance
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Chen J; Shi Y; Liu W ; et al. (2011)
A Pid3 allele from rice cultivar Gumei2 confers resistance to Magnaporthe oryzae.
GP00000883
Pid3
C0LMX9
Physiology
1bp deletion resulting in truncated protein N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Pid3
Oryza sativa
rice - (species)
Published - Accepted by Curator
PigmR
Pathogen resistance (plant fungus pathogen)
Unknown,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Deng Y; Zhai K; Xie Z ; et al. (2017)
Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance.
GP00001592
Pigm_GM4.7
A0A1P8CYR1
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
PigmR
Oryza sativa
rice - (species)
Published - Accepted by Curator
PIK3CG
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001611
PIK3CG
P48736
Physiology
C>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PIK3CG
Homo sapiens
human - (species)
Published - Accepted by Curator
Pikm1-TS + Pikm2-TS cluster
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Ashikawa I; Hayashi N; Yamane H ; et al. (2008)
Two adjacent nucleotide-binding site-leucine-rich repeat class genes are required to confer Pikm-spe[...]
1 Additional References
GP00000884
PIKM1-TS
B5UBC1
Physiology
Coding variation in both genes; with alleles of both genes necessary for resistance in completementation assays
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Pikm1-TS + Pikm2-TS cluster
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pit
Pathogen resistance (rice blast disease; fungal pathogen; Magnaporthe grisea)
Cis-regulatory,
Insertion
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Hayashi K; Yoshida H (2009)
Refunctionalization of the ancient rice blast disease resistance gene Pit by the recruitment of a re[...]
GP00002052
Pit
B9A1G4
Physiology
insertion of a 5.5-kb LTR retrotransposon Renovator upstream of the gene (256‐bp upstream of the predicted start codon for NBSt2K59; in the same orientation as the gene)
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Pit
Oryza sativa
rice - (species)
Published - Accepted by Curator
Piz-t
Pathogen resistance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Zhou B; Qu S; Liu G ; et al. (2006)
The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance [...]
GP00000895
Piz-t
Q0H213
Physiology
Coding variation in the LRR domain
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Piz-t
Oryza sativa
rice - (species)
Published - Accepted by Curator
Pl6
Pathogen resistance
Coding,
Unknown
Helianthus annuus
common sunflower - (species) D
Domesticated
Linkage Mapping
Franchel J; Bouzidi MF; Bronner G ; et al. (2013)
Positional cloning of a candidate gene for resistance to the sunflower downy mildew, Plasmopara hals[...]
GP00000896
F8R6K4
Physiology
unknown ; cluster of several R-protein coding genes; of which only one is expressed
Helianthus annuus
common sunflower - (species)
Helianthus annuus
common sunflower - (species) D
Pl6
Helianthus annuus
common sunflower - (species)
Published - Accepted by Curator
Plasma membrane ATPase 1
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001300
PMA1
P05030
Physiology
A>T (Phe > Ile) @ position 1831
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Plasma membrane ATPase 1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Plasma membrane ATPase 1
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001301
PMA1
P05030
Physiology
T>G (Thr > Pro) @ position 2197
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Plasma membrane ATPase 1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Plasma membrane ATPase 1
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001302
PMA1
P05030
Physiology
G>T (Ala > Asp) @ position 2204
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Plasma membrane ATPase 1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
plg-1
Copulatory plug
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Palopoli MF; Rockman MV; TinMaung A ; et al. (2008)
Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.
GP00000898
Physiology
insertion of transposable element in an exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
plg-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Pm3
Pathogen resistance
Coding,
SNP
Triticum aestivum
bread wheat - (species)
Intraspecific
Linkage Mapping
Yahiaoui N; Kaur N; Keller B (2009)
Independent evolution of functional Pm3 resistance genes in wild tetraploid wheat and domesticated b[...]
1 Additional References
GP00000899
PM3
C1K3M2
Physiology
Various substitution haplotypes - exact causing amino acid change(s) unknown - in hexaploid bread wheat one amino acid change in a solvent‐exposed residue of LRR27 (E1334 to V1334) was sufficient to convert the susceptible Pm3CS into a functional resistance allele (Yahiaoui et al., 2006).
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
Pm3
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Anderson JB; Funt J; Thompson DA ; et al. (2010)
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...]
2 Additional References
GP00000900
PMA1
P05030
Physiology
Leu363Trp
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Anderson JB; Funt J; Thompson DA ; et al. (2010)
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populat[...]
2 Additional References
GP00000901
PMA1
P05030
Physiology
Ser234Cys
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000902
PMA1
P05030
Physiology
Val127Phe
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000903
PMA1
P05030
Physiology
Val157Phe
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000904
PMA1
P05030
Physiology
Gly294Val
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000905
PMA1
P05030
Physiology
Gly337Ser
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000906
PMA1
P05030
Physiology
Met530Ile
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000907
PMA1
P05030
Physiology
Pro535Thr
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000908
PMA1
P05030
Physiology
Iso564Thr
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000909
PMA1
P05030
Physiology
Ala732Val
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMA1
Salt tolerance (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000910
PMA1
P05030
Physiology
Trp750Cys
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMA1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
PMEI6
Mucilage (seeds)
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
1 Additional References
GP00001272
AXX17_At2g45450
A0A178VVA1
Physiology
frameshift mutation due to a 1-bp insertion 581 bp after the ATG codon that changed amino acids 194 to 205 followed by the introduction of a stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PMEI6
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
PMR1
Metal tolerance (manganese)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Linkage Mapping
Sadhu MJ; Bloom JS; Day L ; et al. (2016)
CRISPR-directed mitotic recombination enables genetic mapping without crosses.
GP00000914
PMR1
P13586
Physiology
Leu548Phe
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
PMR1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Pore-forming toxin-like (PFT)
Pathogen resistance (Fusarium)
Gene Loss,
Indel
N
Triticum aestivum
bread wheat - (species)
Intraspecific
Linkage Mapping
Rawat N; Pumphrey MO; Liu S ; et al. (2016)
Wheat Fhb1 encodes a chimeric lectin with agglutinin domains and a pore-forming toxin-like domain co[...]
GP00001563
Q4JEV5
Physiology
PFT gene is present and constitutively expressed in resistant line and absent in susceptible line N
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
Pore-forming toxin-like (PFT)
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
pot-2
Telomere length
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Cook DE; Zdraljevic S; Tanny RE ; et al. (2016)
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.
GP00001317
pot-2
O45595
Physiology
Phenylalanine-to-isoleucine (F68I) N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
pot-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
PPAR-alpha
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Simonson TS; Yang Y; Huff CD ; et al. (2010)
Genetic evidence for high-altitude adaptation in Tibet.
1 Additional References
GP00000917
PPARA
Q07869
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PPAR-alpha
Homo sapiens
human - (species)
Published - Accepted by Curator
PPAR-gamma
Fertility
Cis-regulatory,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Hoedjes KM; Kostic H; Flatt T ; et al. (2023)
A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.
GP00002664
Eip75B
P17672
Physiology
This SNP is biallelic with the “T” variant being more common in the late-reproducing long-lived populations (average frequency: 0.84 “T” / 0.16 “G”) as compared to the early-reproducing populations (average frequency: 0.52 “T” / 0.48 “G”).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
PPAR-gamma
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ppw-1
Resistance to dsRNA
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Tijsterman M; Okihara KL; Thijssen K ; et al. (2002)
PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]
GP00000921
Physiology
1bp deletion resulting in stop codon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
ppw-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Prdm9
Hybrid incompatibility (F1 male sterility)
Recombination rate (use of recombination hotspots)
Unknown,
Unknown
Mus musculus
house mouse - (species)
Intraspecific
Linkage Mapping
Mihola O; Trachtulec Z; Vlcek C ; et al. (2009)
A mouse speciation gene encodes a meiotic histone H3 methyltransferase.
2 Additional References
GP00000922
Prdm9
Q96EQ9
Physiology
Physiology
possible dosage difference (number of gene copies) interacting with an allele that affects post-transcriptional stability
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Prdm9
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Prdm9
Recombination rate (use of recombination hotspots)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Berg IL; Neumann R; Sarbajna S ; et al. (2011)
Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots [...]
GP00000923
Prdm9
Q96EQ9
Physiology
Various haplotypes
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Prdm9
Homo sapiens
human - (species)
Published - Accepted by Curator
PRDM9
Recombination rate (male)
Coding,
Deletion
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Sandor C; Li W; Coppieters W ; et al. (2012)
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
GP00001640
PRDM9
A6QNW2
Physiology
variation in the C-terminal tandem array of Cys2His2 zinc-finger domains: 22 domains > 20 domains decreasing 6-fold Genome wide hot window usage in Crossing Over
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
PRDM9
Bos taurus
cattle - (species)
Published - Accepted by Curator
PRDM9
Recombination rate (male)
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Sandor C; Li W; Coppieters W ; et al. (2012)
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
GP00001641
PRDM9
A6QNW2
Physiology
variation in the C-terminal tandem array of Cys2His2 zinc-finger domains: T68A p.I23K in domain 11 has a major effect. K allele decreasing 30-fold Genome wide hot window usage in Crossing Over compared to I allele
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
PRDM9
Bos taurus
cattle - (species)
Published - Accepted by Curator
PRDM9
Recombination rate (male)
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Sandor C; Li W; Coppieters W ; et al. (2012)
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
GP00001642
PRDM9
A6QNW2
Physiology
variation in the C-terminal tandem array of Cys2His2 zinc-finger domains: T20C p.A>Y sustitutions in domains 14. Y allele increasing 6-fold Genome wide hot window usage in Crossing Over
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
PRDM9
Bos taurus
cattle - (species)
Published - Accepted by Curator
PRKCD
Pathogen resistance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001381
PRKCD
Q05655
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
PRKCD
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
prodynorphin (PDYN)
Neuroendocronological homeostasis
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Interspecific
Candidate Gene
Rockman MV; Hahn MW; Soranzo N ; et al. (2005)
Ancient and recent positive selection transformed opioid cis-regulation in humans.
1 Additional References
GP00000924
PDYN
P01213
Physiology
up to 5 polymorphisms in 5' regulatory region
Primates
(order)
Homo sapiens
human - (species)
prodynorphin (PDYN)
Homo sapiens
human - (species)
Published - Accepted by Curator
Prolactin (deciduous Prolactin; dPRL)
Gene expression change (quantitative; increase)
Cis-regulatory,
SNP
Homininae
(subfamily)
Intergeneric or Higher
Candidate Gene
Emera D; Wagner GP (2012)
Transformation of a transposon into a derived prolactin promoter with function during human pregnanc[...]
GP00000926
PRL
P01236
Physiology
Acquisition of enhancer activity in transposons via several base-pair substitutions
Primates
(order)
Homininae
(subfamily)
Prolactin (deciduous Prolactin; dPRL)
Homininae
(subfamily)
Published - Accepted by Curator
Prolactin receptor
Milk yield
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Candidate Gene
Viitala S; Szyda J; Blott S ; et al. (2006)
The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein[...]
GP00000927
PRLR
P16471
Physiology
Ser18Asn
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Hair (slick ; short ; thermotolerance)
Thermoregulation (tolerance to warm climate)
Coding,
Deletion
N
Bos taurus
cattle - (species) D
Domesticated
Littlejohn MD; Henty KM; Tiplady K ; et al. (2014)
Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.
GP00002282
PRLR
P16471
Morphology
Physiology
g.39136559delC p.Leu462* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Hair (slick ; short)
Thermoregulation (tolerance to warm climate)
Coding,
SNP
N
Bos taurus
cattle - (species) D
Domesticated
Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018)
Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.
GP00002283
PRLR
P16471
Morphology
Physiology
g.39136571C>A p.Ser465* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Hair (slick ; short)
Thermoregulation (tolerance to warm climate)
Coding,
SNP
N
Bos taurus
cattle - (species) D
Domesticated
Porto-Neto LR; Bickhart DM; Landaeta-Hernandez AJ ; et al. (2018)
Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor.
GP00002284
PRLR
P16471
Morphology
Physiology
g.39136666C>T p.Arg497* N
Bos taurus
cattle - (species)
Bos taurus
cattle - (species) D
Prolactin receptor
Bos taurus
cattle - (species)
Published - Accepted by Curator
Prolactin receptor
Fertility
Cis-regulatory,
Insertion
Sus scrofa domesticus
domestic pig - (subspecies) D
Domesticated
Linkage Mapping
Sironen A; Fischer D; Laiho A ; et al. (2014)
A recent L1 insertion within SPEF2 gene is associated with changes in PRLR expression in sow reprodu[...]
1 Additional References
GP00002339
PRLR
P16471
Physiology
L1 insertion in sperm-factor SPEF2 gene causes sperm defect but also downregulation of PRLR
Sus scrofa domesticus
domestic pig - (subspecies)
Sus scrofa domesticus
domestic pig - (subspecies) D
Prolactin receptor
Sus scrofa domesticus
domestic pig - (subspecies)
Published - Accepted by Curator
Prolactin releasing hormone receptor (Prlhr/GPR10)
Body size (weight)
Cis-regulatory,
Unknown
Mus musculus
house mouse - (species)
Domesticated
Association Mapping
Chan YF; Jones FC; McConnell E ; et al. (2012)
Parallel selection mapping using artificially selected mice reveals body weight control loci.
GP00000928
PRLHR
P49683
Physiology
unknown
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Prolactin releasing hormone receptor (Prlhr/GPR10)
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Proline specific permease PUT4
Nitrogen use (growth rate on proline)
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001501
PUT4
P15380
Physiology
several synonymous and promoter mutations
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Proline specific permease PUT4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
prophenoloxidase 1 (PPO1)
Enzymatic activity
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Asada N (1997)
Genetic variants affecting phenoloxidase activity in Drosophila melanogaster.
GP00002001
Physiology
Exact causing mutation(s) unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
prophenoloxidase 1 (PPO1)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
prophenoloxidase 3 (PPO3)
Immune response (melanotic encapsulation by lamellocytes)
Coding,
SNP
N
Drosophila sechellia
(species) D
Interspecific
Candidate Gene
Dudzic JP; Kondo S; Ueda R ; et al. (2015)
Drosophila innate immunity: regional and functional specialization of prophenoloxidases.
GP00001781
PPO3
Q9W1V6
Physiology
amino acid change at position 48 which converts the terminal glutamine residue of the propeptide region to a stop codon, and is predicted to generate a truncated version of the PPO3 protein N
Drosophila simulans
(species)
Drosophila mauritiana
(species)
Drosophila sechellia
(species) D
prophenoloxidase 3 (PPO3)
Drosophila sechellia
(species)
Published - Accepted by Curator
protein phosphatase
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001534
PF3D7_1012700
Q8IJR8
Physiology
p.Val1157Leu
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
protein phosphatase
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
protoporphyrinogen oxidase (PPO2 = PPX2L)
Xenobiotic resistance (herbicides)
Coding,
Deletion
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt WL; Hager AG; McCormick JS ; et al. (2006)
A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase.
GP00000929
PPX2L
Q0NZW6
Physiology
3bp deletion; deletion of G210
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
protoporphyrinogen oxidase (PPO2 = PPX2L)
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time
Coding,
Deletion
N
Sorghum bicolor
sorghum - (species) D
Domesticated
Linkage Mapping
Murphy RL; Klein RR; Morishige DT ; et al. (2011)
Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]
GP00000930
PRR37
Q0D3B6
Physiology
1bp deletion resulting in frameshift N
Sorghum bicolor
sorghum - (species)
Sorghum bicolor
sorghum - (species) D
PRR37 pseudoresponse regulator protein 37
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time
2 Mutations:
Coding
SNP
N
Sorghum bicolor
sorghum - (species)
Domesticated
Linkage Mapping
Murphy RL; Klein RR; Morishige DT ; et al. (2011)
Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]
GP00000931
PRR37
Q0D3B6
Physiology
2 mutations
Sorghum bicolor
sorghum - (species)
Sorghum bicolor
sorghum - (species)
PRR37 pseudoresponse regulator protein 37
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time
Coding,
SNP
Sorghum bicolor
sorghum - (species)
Domesticated
Linkage Mapping
Murphy RL; Klein RR; Morishige DT ; et al. (2011)
Coincident light and clock regulation of pseudoresponse regulator protein 37 (PRR37) controls photop[...]
GP00000932
PRR37
Q0D3B6
Physiology
K162N
Sorghum bicolor
sorghum - (species)
Sorghum bicolor
sorghum - (species)
PRR37 pseudoresponse regulator protein 37
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time (heading date)
Coding,
SNP
N
Oryza sativa Japonica Group
Japanese rice - (no rank) D
Domesticated
Linkage Mapping
Koo BH; Yoo SC; Park JW ; et al. (2013)
Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]
GP00001632
PRR37
Q0D3B6
Physiology
Nonfunctional allele PRR37-2a: L710P missense mutation in the CONSTANS-Co-like and TOC1 domain of the protein N
Oryza sativa
rice - (species)
Oryza sativa Japonica Group
Japanese rice - (no rank) D
PRR37 pseudoresponse regulator protein 37
Oryza sativa Japonica Group
Japanese rice - (no rank)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time (heading date)
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Koo BH; Yoo SC; Park JW ; et al. (2013)
Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]
GP00001633
PRR37
Q0D3B6
Physiology
Nonfunctional allele PRR37-1a: a 8-bp deletion at position 1515 leading to frameshift N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
PRR37 pseudoresponse regulator protein 37
Oryza sativa
rice - (species)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time (heading date)
Coding,
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Koo BH; Yoo SC; Park JW ; et al. (2013)
Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]
GP00001634
PRR37
Q0D3B6
Physiology
Nonfunctional allele PRR37-1b: Y704H N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
PRR37 pseudoresponse regulator protein 37
Oryza sativa
rice - (species)
Published - Accepted by Curator
PRR37 pseudoresponse regulator protein 37
Flowering time (heading date)
Coding,
SNP
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Koo BH; Yoo SC; Park JW ; et al. (2013)
Natural variation in OsPRR37 regulates heading date and contributes to rice cultivation at a wide ra[...]
GP00001635
PRR37
Q0D3B6
Physiology
Nonfunctional allele PRR37-1c: a premature stop Q705* N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
PRR37 pseudoresponse regulator protein 37
Oryza sativa
rice - (species)
Published - Accepted by Curator
PRR37-like Photoperiod-H1 (Ppd-H1)
Flowering time
Unknown,
Unknown
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Turner A; Beales J; Faure S ; et al. (2005)
The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley.
1 Additional References
GP00000933
PRR37
Q0D3B6
Physiology
unknown
Hordeum vulgare
(species)
Hordeum vulgare
(species)
PRR37-like Photoperiod-H1 (Ppd-H1)
Hordeum vulgare
(species)
Published - Accepted by Curator
PSMD13
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001615
PSMD13
Q9UNM6
Physiology
A>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PSMD13
Homo sapiens
human - (species)
Published - Accepted by Curator
PSST
Xenobiotic resistance (METI-I acaricide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Bajda S; Dermauw W; Panteleri R ; et al. (2017)
A mutation in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Tetranychus urti[...]
GP00002635
ND-20
Q9VXK7
Physiology
H92R
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
PSST
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
PSST
Xenobiotic resistance (METI-I acaricide)
Coding,
SNP
Panonychus citri
citrus red mite - (species) D
Intraspecific
Candidate Gene
Alavijeh ES; Khajehali J; Snoeck S ; et al. (2020)
Molecular and genetic analysis of resistance to METI-I acaricides in Iranian populations of the citr[...]
GP00002636
ND-20
Q9VXK7
Physiology
H92R
Panonychus citri
citrus red mite - (species)
Panonychus citri
citrus red mite - (species) D
PSST
Panonychus citri
citrus red mite - (species)
Published - Accepted by Curator
Pto
Pathogen resistance
Unknown,
Unknown
Solanum lycopersicum
tomato - (species)
Domesticated
Linkage Mapping
Martin GB; Brommonschenkel SH; Chunwongse J ; et al. (1993)
Map-based cloning of a protein kinase gene conferring disease resistance in tomato.
GP00000937
pto
P93215
Physiology
Not identified
Solanum lycopersicum
tomato - (species)
Solanum lycopersicum
tomato - (species)
Pto
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
PTPN1
High-altitude adaptation
Coding,
SNP
Locusta migratoria
migratory locust - (species) D
Intraspecific
Association Mapping
Ding D; Liu G; Hou L ; et al. (2018)
Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan m[...]
GP00002668
P18031NULL
Physiology
one nonsynonymous mutation (c.1046A>T) in PTPN1 in Tibetan locusts which encodes the amino acid substitution p.Asn349Ile at the proline (Pro)-rich domain of PTP1B.
Locusta migratoria
migratory locust - (species)
Locusta migratoria
migratory locust - (species) D
PTPN1
Locusta migratoria
migratory locust - (species)
Published - Accepted by Curator
PVX_084940
Xenobiotic resistance (multiresistance to antimalarial drugs)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001487
PVX_084940
A5K0T0
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species)
PVX_084940
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
PVX_101445
Xenobiotic resistance (chloroquine)
Gene Amplification,
Insertion
Plasmodium vivax
malaria parasite P. vivax - (species) D
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001483
PVX_101445
A5K913
Physiology
3 kb duplication on chromosome 14 that includes PVX_101445
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species) D
PVX_101445
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
qSH1
Seed shattering
Cis-regulatory,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Konishi S; Izawa T; Lin SY ; et al. (2006)
An SNP caused loss of seed shattering during rice domestication.
GP00000942
qSH1
Q941S9
Physiology
1bp change
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
qSH1
Oryza sativa
rice - (species)
Published - Accepted by Curator
qSH1 (REPLUMLESS)
Seed shattering
Cis-regulatory,
SNP
Brassicaceae
mustard family - (family)
Interspecific
Candidate Gene
Arnaud N; Lawrenson T; Østergaard L ; et al. (2011)
The same regulatory point mutation changed seed-dispersal structures in evolution and domestication.
GP00000943
qSH1
Q941S9
Physiology
1bp change
Brassicaceae
mustard family - (family)
Brassicaceae
mustard family - (family)
qSH1 (REPLUMLESS)
Brassicaceae
mustard family - (family)
Published - Accepted by Curator
RAC1
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Borhan MH; Holub EB; Beynon JL ; et al. (2004)
The arabidopsis TIR-NB-LRR gene RAC1 confers resistance to Albugo candida (white rust) and is depend[...]
GP00000949
ARAC3
Q38912
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RAC1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RAD5
Xenobiotic resistance
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Demogines A; Smith E; Kruglyak L ; et al. (2008)
Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast.
1 Additional References
GP00000950
RAD5
P32849
Physiology
I791S
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
RAD5
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Rap2.7 (vgt1)
Flowering time
Cis-regulatory,
Unknown
Zea mays
(species)
Domesticated
Linkage Mapping
Salvi S; Sponza G; Morgante M ; et al. (2007)
Conserved noncoding genomic sequences associated with a flowering-time quantitative trait locus in m[...]
1 Additional References
GP00000951
RAP2-7
Q9SK03
Physiology
2kb-sequence located 70kb upstream of the Vg1 transcription start site - insertion of a miniature transposon (MITE) belonging to the Tourist family
Zea mays
(species)
Zea mays
(species)
Rap2.7 (vgt1)
Zea mays
(species)
Published - Accepted by Curator
RAS1
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000952
RAS2
P01120
Physiology
Glu>Ala (A>C mutation)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RAS1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RAS1
Salt tolerance
Abscisic acid sensitivity
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ren Z; Zheng Z; Chinnusamy V ; et al. (2010)
RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis.
GP00000953
RAS1
O04515
Physiology
Physiology
Premature stop codon; Lys>STOP N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RAS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RAS2
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000954
RAS2
P01120
Physiology
Gly>Ser (C>T mutation)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RAS2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RAS2
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kohn LM; Anderson JB (2014)
The underlying structure of adaptation under strong selection in 12 experimental yeast populations.
GP00000955
RAS2
P01120
Physiology
Glu>Gln (C>G mutation)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RAS2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RAS2
Sporulation efficiency
Cis-regulatory,
Insertion
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Linkage Mapping
Ben-Ari G; Zenvirth D; Sherman A ; et al. (2006)
Four linked genes participate in controlling sporulation efficiency in budding yeast.
GP00000956
RAS2
P01120
Physiology
1bp insertion in promoter
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RAS2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RCR3
Pathogen resistance
Coding,
SNP
Solanum peruvianum
(species)
Intraspecific
Candidate Gene
Hörger AC; Ilyas M; Stephan W ; et al. (2012)
Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathog[...]
GP00000963
Rcr3
Q8S333
Physiology
Candidate amino acid changes are I206K and/or Q222E and/or S330A
Solanum peruvianum
(species)
Solanum peruvianum
(species)
RCR3
Solanum peruvianum
(species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001246
At4g11040
Q9T010
Physiology
G892A
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Gene Loss,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001247
At4g11040
Q9T010
Physiology
gene loss: -5.7KB at position -4.38KB N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001248
At4g11040
Q9T010
Physiology
-23bp at position 1371 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001249
At4g11040
Q9T010
Physiology
-25bp at position 25 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001250
At4g11040
Q9T010
Physiology
-50bp at position 50; -390bp at position 504 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001251
At4g11040
Q9T010
Physiology
-13bp at position 1440 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001252
At4g11040
Q9T010
Physiology
-2bp at position 1456 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001253
At4g11040
Q9T010
Physiology
-4bp at position 1391 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001254
At4g11040
Q9T010
Physiology
-16bp at position 1054 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001255
At4g11040
Q9T010
Physiology
-19bp at position 594 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001256
At4g11040
Q9T010
Physiology
-2bp at position 606 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001257
At4g11040
Q9T010
Physiology
-4bp at position 11 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001258
At4g11040
Q9T010
Physiology
C684A which causes C135* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001259
At4g11040
Q9T010
Physiology
4 amino acid changes: N45K; G54R; T55K; E208A - the effect of each single amino acid change has not been tested N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001260
At4g11040
Q9T010
Physiology
-1bp at position 498 causing premature STOP N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001261
At4g11040
Q9T010
Physiology
-1bp at position 498 causing premature STOP N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Rds2
Oxidative stress resistance
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Diezmann S; Dietrich FS (2011)
Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major qu[...]
GP00000964
RDS2
P19541
Physiology
H251D
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
Rds2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
REC114
Recombination rate
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001661
REC114
Q7Z4M0
Physiology
On chromosome 10. Associated SNP located dowstream of the gene
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
REC114
Bos taurus
cattle - (species)
Published - Accepted by Curator
REC8
Recombination rate (male)
Cis-regulatory,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Sandor C; Li W; Coppieters W ; et al. (2012)
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
GP00001638
REC8
E1BL69
Physiology
A>G in intron 12 with reduction in Genome-wide recombination rate
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
REC8
Bos taurus
cattle - (species)
Published - Accepted by Curator
ref(2)P
Pathogen resistance (sigma virus)
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Dru P; Bras F; Dezélée S ; et al. (1993)
Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...]
2 Additional References
GP00001994
ref(2)P
P14199
Physiology
Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pn strains. Exact causing mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
ref(2)P
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ref(2)P
Pathogen resistance (sigma virus)
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Dru P; Bras F; Dezélée S ; et al. (1993)
Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...]
2 Additional References
GP00001995
ref(2)P
P14199
Physiology
Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pp strains. Exact causing mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
ref(2)P
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Resistance related Kinase 1 (RKS1)
Pathogen resistance (plant bacteria)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Domesticated
Linkage Mapping
Huard-Chauveau C; Perchepied L; Debieu M ; et al. (2013)
An atypical kinase under balancing selection confers broad-spectrum disease resistance in Arabidopsi[...]
GP00001599
F15B8.100
Q9SVY5
Physiology
a single-SNP difference in the coding region resulting in an amino acid change in the activation segment relative to the catalytic kinase loop. Other polymorphisms were found in the 5' and 3' regulatory regions. RKS1-L expression is 235.1 fold higher
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Resistance related Kinase 1 (RKS1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Thompson M; Shotkoski F; ffrench-Constant R (1993)
Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]
GP00000968
Rdl
P25123
Physiology
Ala302Ser
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
resistance to dieldrin
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles arabiensis
(species) D
Intraspecific
Candidate Gene
Du W; Awolola TS; Howell P ; et al. (2005)
Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]
GP00000969
Rdl
P25123
Physiology
Ala302Ser
Anopheles arabiensis
(species)
Anopheles arabiensis
(species) D
resistance to dieldrin
Anopheles arabiensis
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Du W; Awolola TS; Howell P ; et al. (2005)
Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]
GP00000970
Rdl
P25123
Physiology
Ala302Gly
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
resistance to dieldrin
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Anthony NM; Brown JK; Markham PG ; et al. (1995
)
Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...]
1 Additional References
GP00000971
Rdl
P25123
Physiology
2 mutations
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
resistance to dieldrin
Bemisia tabaci
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Kaku K; Matsumura F (1994)
Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]
GP00000972
Rdl
P25123
Physiology
Ala302Ser
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
resistance to dieldrin
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Ctenocephalides felis
cat flea - (species) D
Intraspecific
Candidate Gene
Bass C; Schroeder I; Turberg A ; et al. (2004)
Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]
GP00000973
Rdl
P25123
Physiology
Ala302Ser
Ctenocephalides felis
cat flea - (species)
Ctenocephalides felis
cat flea - (species) D
resistance to dieldrin
Ctenocephalides felis
cat flea - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993)
A point mutation in a Drosophila GABA receptor confers insecticide resistance.
2 Additional References
GP00000974
Rdl
P25123
Physiology
Ala302Ser - G9155164T
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
resistance to dieldrin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Lee HJ; Rocheleau T; Zhang HG ; et al. (1993)
Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...]
1 Additional References
GP00000975
Rdl
P25123
Physiology
Ala302Ser
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Lee HJ; Rocheleau T; Zhang HG ; et al. (1993)
Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...]
1 Additional References
GP00000976
Rdl
P25123
Physiology
Ala302Gly
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Hypothenemus hampei
coffee berry borer - (species) D
Intraspecific
Candidate Gene
Brun LO; Stuart J; Gaudichon V ; et al. (1995)
Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...]
2 Additional References
GP00000977
Rdl
P25123
Physiology
Ala302Ser
Hypothenemus hampei
coffee berry borer - (species)
Hypothenemus hampei
coffee berry borer - (species) D
resistance to dieldrin
Hypothenemus hampei
coffee berry borer - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Thompson M; Steichen JC; ffrench-Constant RH (1993)
Conservation of cyclodiene insecticide resistance-associated mutations in insects.
GP00000978
Rdl
P25123
Physiology
Ala302Ser
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
resistance to dieldrin
Musca domestica
house fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Anthony N; Unruh T; Ganser D ; et al. (1998)
Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.
GP00000979
Rdl
P25123
Physiology
Ala302Gly
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
resistance to dieldrin
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Periplaneta americana
American cockroach - (species) D
Intraspecific
Candidate Gene
Thompson M; Steichen JC; ffrench-Constant RH (1993)
Conservation of cyclodiene insecticide resistance-associated mutations in insects.
GP00000980
Rdl
P25123
Physiology
Ala302Ser
Periplaneta americana
American cockroach - (species)
Periplaneta americana
American cockroach - (species) D
resistance to dieldrin
Periplaneta americana
American cockroach - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Tribolium castaneum
red flour beetle - (species)
Intraspecific
Candidate Gene
Miyazaki M; Matsumura F; Beeman RW (1995)
DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...]
1 Additional References
GP00000981
Rdl
P25123
Physiology
Ala302Ser
Tribolium castaneum
red flour beetle - (species)
Tribolium castaneum
red flour beetle - (species)
resistance to dieldrin
Tribolium castaneum
red flour beetle - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Le Goff G; Hamon A; Bergé JB ; et al. (2005)
Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]
GP00001981
Rdl
P25123
Physiology
2 mutations
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
ffrench-Constant RH; Steichen JC; Rocheleau TA ; et al. (1993)
A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]
GP00001982
Rdl
P25123
Physiology
Ala301Ser - The lesion in the RdlMD-RR allele has been described as A302S in print but the amino acid replacement is actually A301S.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
resistance to dieldrin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Remnant EJ; Good RT; Schmidt JM ; et al. (2013)
Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster.
GP00002452
Rdl
P25123
Physiology
113-kb duplication containing one WT copy of Rdl and a second copy with two point mutations: an Ala(301) to Ser resistance mutation and Met(360) to Ile replacement. Individuals with this duplication exhibit intermediate dieldrin resistance compared with single copy Ser(301) homozygotes and reduced temperature sensitivity and altered RNA editing associated with the resistant allele. Ectopic recombination between Roo transposable elements is involved in generating this genomic rearrangement. The duplication phenotypes were confirmed by construction of a transgenic artificial duplication integrating the 55.7-kb Rdl locus with a Ser(301) change into an Ala(301) background.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
resistance to dieldrin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Anopheles funestus
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Wondji CS; Dabire RK; Tukur Z ; et al. (2011)
Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the ma[...]
GP00002557
Rdl
P25123
Physiology
2 mutations
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species) D
resistance to dieldrin
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Domingues LN; Guerrero FD; Becker ME ; et al. (2013)
Discovery of the Rdl mutation in association with a cyclodiene resistant population of horn flies, H[...]
1 Additional References
GP00002558
Rdl
P25123
Physiology
Ala301Ser
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
resistance to dieldrin
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Tantely ML; Tortosa P; Alout H ; et al. (2010)
Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...]
1 Additional References
GP00002559
Rdl
P25123
Physiology
Ala301Ser
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
resistance to dieldrin
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Tantely ML; Tortosa P; Alout H ; et al. (2010)
Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...]
1 Additional References
GP00002560
Rdl
P25123
Physiology
Ala301Ser
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
resistance to dieldrin
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Laodelphax striatellus
small brown planthopper - (species) D
Intraspecific
Candidate Gene
Nakao T; Kawase A; Kinoshita A ; et al. (2011)
The A2'N mutation of the RDL gamma-aminobutyric acid receptor conferring fipronil resistance in Laod[...]
1 Additional References
GP00002561
Rdl
P25123
Physiology
A301N
Laodelphax striatellus
small brown planthopper - (species)
Laodelphax striatellus
small brown planthopper - (species) D
resistance to dieldrin
Laodelphax striatellus
small brown planthopper - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Experimental Evolution
Candidate Gene
Li A; Yang Y; Wu S ; et al. (2006)
Investigation of resistance mechanisms to fipronil in diamondback moth (Lepidoptera: Plutellidae).
1 Additional References
GP00002562
Rdl
P25123
Physiology
A302(GGC)--> S302(TCC)
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
resistance to dieldrin
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Sogatella furcifera
white-backed planthopper - (species) D
Experimental Evolution
Candidate Gene
Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010
)
Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...]
1 Additional References
GP00002563
Rdl
P25123
Physiology
2 mutations
Sogatella furcifera
white-backed planthopper - (species)
Sogatella furcifera
white-backed planthopper - (species) D
resistance to dieldrin
Sogatella furcifera
white-backed planthopper - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Oulema oryzae
rice leaf beetle - (species) D
Experimental Evolution
Candidate Gene
Nakao Toshifumi; Naoi Atsuko; Kawahara Nobuyuki ; et al. (2010
)
Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, So[...]
1 Additional References
GP00002564
Rdl
P25123
Physiology
A301S
Oulema oryzae
rice leaf beetle - (species)
Oulema oryzae
rice leaf beetle - (species) D
resistance to dieldrin
Oulema oryzae
rice leaf beetle - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Diabrotica virgifera
(species) D
Intraspecific
Candidate Gene
Wang H; Coates BS; Chen H ; et al. (2013)
Role of a γ-aminobutryic acid (GABA) receptor mutation in the evolution and spread of Diabrotica vir[...]
1 Additional References
GP00002566
Rdl
P25123
Physiology
A301S
Diabrotica virgifera
(species)
Diabrotica virgifera
(species) D
resistance to dieldrin
Diabrotica virgifera
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
Hope M; Menzies M; Kemp D (2010)
Identification of a dieldrin resistance-associated mutation in Rhipicephalus (Boophilus) microplus ([...]
1 Additional References
GP00002567
Rdl
P25123
Physiology
T305L
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
resistance to dieldrin
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
resistant to methyl viologen 1 (RMV1)
Polyamine uptake
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Fujita M; Fujita Y; Iuchi S ; et al. (2012)
Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis.
GP00000982
RMV1
Q9FFL1
Physiology
Ile377Phe N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
resistant to methyl viologen 1 (RMV1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
retr02/eIF(iso)4E
Pathogen resistance (plant virus)
Coding,
SNP
Brassica rapa
field mustard - (species) D
Domesticated
Linkage Mapping
Qian W; Zhang S; Zhang S ; et al. (2013)
Mapping and candidate-gene screening of the novel Turnip mosaic virus resistance gene retr02 in Chin[...]
GP00000983
EIF(ISO)4E
O04663
Physiology
G152R
Brassica rapa
field mustard - (species)
Brassica rapa
field mustard - (species) D
retr02/eIF(iso)4E
Brassica rapa
field mustard - (species)
Published - Accepted by Curator
RGC2/Dm3
Pathogen resistance
Coding,
Unknown
Lactuca serriola
(species)
Domesticated
Linkage Mapping
Kuang H; Ochoa OE; Nevo E ; et al. (2006)
The disease resistance gene Dm3 is infrequent in natural populations of Lactuca serriola due to dele[...]
GP00000984
RGC2
Q6Y136
Physiology
Various haplotypes detected using PCR - absence of amplification could be due to deletion or to gene conversion
Lactuca serriola
(species)
Lactuca serriola
(species)
RGC2/Dm3
Lactuca serriola
(species)
Published - Accepted by Curator
Rgh4
Pathogen resistance (cyst nematode; parasite)
2 Mutations:
Coding
SNP
Glycine max
soybean - (species)
Domesticated
Linkage Mapping
Liu S; Kandoth PK; Warren SD ; et al. (2012)
A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens.
GP00001049
SHMT
K4FZF8
Physiology
2 mutations
Glycine max
soybean - (species)
Glycine max
soybean - (species)
Rgh4
Glycine max
soybean - (species)
Published - Accepted by Curator
Rhg1
Pathogen resistance (cyst nematode)
Gene Amplification,
Complex Change
Glycine max
soybean - (species)
Intraspecific
Linkage Mapping
Cook DE; Lee TG; Guo X ; et al. (2012)
Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean.
GP00000985
rhg1s
Q8L3Y5
Physiology
Copy number Variant : 10-tandem copies of the gene cluster in resistant strains ; the 3 dissimilar genes participate to resistance
Glycine max
soybean - (species)
Glycine max
soybean - (species)
Rhg1
Glycine max
soybean - (species)
Published - Accepted by Curator
Rhg1
Pathogen resistance (cyst nematode)
Cis-regulatory,
Insertion
Glycine max
soybean - (species) D
Intraspecific
Linkage Mapping
Bayless AM; Zapotocny RW; Han S ; et al. (2019)
The rhg1-a (Rhg1 low-copy) nematode resistance source harbors a copia-family retrotransposon within [...]
GP00002049
rhg1s
Q8L3Y5
Physiology
insertion of a copia retrotransposon within the gene Rhg1 Glyma.18G022500 (α-SNAP-encoding). This transposable element is intact and resides within intron 1; anti-sense to the rhg1-a α-SNAP open reading frame.
Glycine max
soybean - (species)
Glycine max
soybean - (species) D
Rhg1
Glycine max
soybean - (species)
Published - Accepted by Curator
RHO2
Temperature tolerance / virulence
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
1 Additional References
GP00000986
RHO2
P06781
Physiology
3'UTR polymorphism
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
RHO2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Rhodopsin (RH1)
Color vision (blue shift)
Coding,
SNP
Thunnus orientalis
Pacific bluefin tuna - (species) D
Intergeneric or Higher
Candidate Gene
Nakamura Y; Mori K; Saitoh K ; et al. (2013)
Evolutionary changes of multiple visual pigment genes in the complete genome of Pacific bluefin tuna[...]
GP00001468
rho
P35359
Physiology
p.E122Q (G>C)
Percomorphaceae
(no rank)
Thunnus orientalis
Pacific bluefin tuna - (species) D
Rhodopsin (RH1)
Thunnus orientalis
Pacific bluefin tuna - (species)
Published - Accepted by Curator
ribonuclease 1B (RNase1B)
Optimal enzymatic pH
3 Mutations:
Coding
SNP
Pygathrix nemaeus
Red shanked douc langur - (species) D
Intergeneric or Higher
Candidate Gene
Zhang J (2006)
Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.
GP00000987
RNASE1B
Q8SPN3
Physiology
3 mutations
Primates
(order)
Pygathrix nemaeus
Red shanked douc langur - (species) D
ribonuclease 1B (RNase1B)
Pygathrix nemaeus
Red shanked douc langur - (species)
Published - Accepted by Curator
ribonuclease 1B (RNase1B)
Optimal enzymatic pH
3 Mutations:
Coding
SNP
Colobus guereza
mantled guereza - (species)
Intergeneric or Higher
Candidate Gene
Zhang J (2006)
Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys.
GP00000988
RNASE1B
Q8SPN3
Physiology
3 mutations
Primates
(order)
Colobus guereza
mantled guereza - (species)
ribonuclease 1B (RNase1B)
Colobus guereza
mantled guereza - (species)
Published - Accepted by Curator
RIM15
Low-glucose adaptation (experimental evolution)
Coding,
Deletion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00000989
RIM15
P43565
Physiology
1bp deletion resulting in premature stop codon N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RIM15
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ripening inhibitor (rin) = LeMADS-RIN and LeMADS-MC
Fruit ripening
Gene Loss,
Deletion
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Vrebalov J; Ruezinsky D; Padmanabhan V ; et al. (2002)
A MADS-box gene necessary for fruit ripening at the tomato ripening-inhibitor (rin) locus.
1 Additional References
GP00000990
MADS-RIN
Q8S4L4
Physiology
2.6kb deletion of the region located between gene LeMADS-RIN and gene LeMADS-MC; resulting in a chimeric mRNA that contains both LeMADS-RIN and LeMADS-MC coding regions.
Solanum lycopersicum
tomato - (species)
Solanum lycopersicum
tomato - (species) D
ripening inhibitor (rin) = LeMADS-RIN and LeMADS-MC
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
RLM1
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Staal J; Kaliff M; Bohman S ; et al. (2006)
Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]
GP00000991
RLM1A
F4I594
Physiology
Digenic; deletion of gene1 and premature stop codons in gene2 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RLM1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RLM2 cluster
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Staal J; Kaliff M; Bohman S ; et al. (2006)
Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]
GP00000992
RLM1B
Q9CAK1
Physiology
the locus contains two paralogues; one of which is deleted and the other pseudogenized in Ler-0 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RLM2 cluster
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RLM3
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Staal J; Kaliff M; Dewaele E ; et al. (2008)
RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fun[...]
GP00000993
RLM3
Q9FT77
Physiology
gene deletion N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RLM3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RME1
Sporulation efficiency
Cis-regulatory,
Deletion
Saccharomyces cerevisiae
baker's yeast - (species) D
Domesticated
Linkage Mapping
Deutschbauer AM; Davis RW (2005)
Quantitative trait loci mapped to single-nucleotide resolution in yeast.
GP00000994
RME1
P32338
Physiology
single nucleotide deletion in promoter region
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RME1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RME1 [possible pseudo-replicate of laboratory strain entry]
Sporulation efficiency
Cis-regulatory,
Deletion
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Gerke J; Lorenz K; Cohen B (2009)
Genetic interactions between transcription factors cause natural variation in yeast.
GP00000995
RME1
P32338
Physiology
single nucleotide deletion in promoter region
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RME1 [possible pseudo-replicate of laboratory strain entry]
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RNASE1B
Folivory (digestion of bacteria at low pH)
Coding,
SNP
Colobus guereza
mantled guereza - (species) D
Piliocolobus badius
western red colobus - (species) D
Intergeneric or Higher
Candidate Gene
Zhou X; Wang B; Pan Q ; et al. (2014)
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]
GP00001412
RNASE1B
Q8SPN3
Physiology
p.Arg39Trp
Macaca mulatta
Rhesus monkey - (species)
Colobus guereza
mantled guereza - (species) D
Piliocolobus badius
western red colobus - (species) D
RNASE1B
Colobus guereza
mantled guereza - (species)
Piliocolobus badius
western red colobus - (species)
Published - Accepted by Curator
RNASE1B
Folivory (digestion of bacteria at low pH)
Coding,
SNP
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
Nasalis larvatus
proboscis monkey - (species) D
Pygathrix nemaeus
Red shanked douc langur - (species) D
Intergeneric or Higher
Candidate Gene
Zhou X; Wang B; Pan Q ; et al. (2014)
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]
GP00001413
RNASE1B
Q8SPN3
Physiology
p.Arg39Trp
Colobinae
(subfamily)
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
Nasalis larvatus
proboscis monkey - (species) D
Pygathrix nemaeus
Red shanked douc langur - (species) D
RNASE1B
Rhinopithecus roxellana
golden snub-nosed monkey - (species)
Nasalis larvatus
proboscis monkey - (species)
Pygathrix nemaeus
Red shanked douc langur - (species)
Published - Accepted by Curator
RNASE1B
Folivory (digestion of bacteria at low pH)
Coding,
SNP
Presbytis melalophos
mitred leaf monkey - (species) D
Interspecific
Candidate Gene
Zhou X; Wang B; Pan Q ; et al. (2014)
Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary hi[...]
GP00001414
RNASE1B
Q8SPN3
Physiology
p.Arg39Gln
Colobinae
(subfamily)
Presbytis melalophos
mitred leaf monkey - (species) D
RNASE1B
Presbytis melalophos
mitred leaf monkey - (species)
Published - Accepted by Curator
RNASE4
High-altitude adaptation (enhanced angiogenesis)
2 Mutations:
Coding
SNP
Rhinopithecus strykeri
Burmese snub-nosed monkey - (species) D
Rhinopithecus bieti
black snub-nosed monkey - (species) D
Interspecific
Association Mapping
Yu L; Wang GD; Ruan J ; et al. (2016)
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]
GP00001505
RNASE4
P34096
Physiology
2 mutations
Rhinopithecus avunculus
Tonkin snub-nosed monkey - (species)
Rhinopithecus strykeri
Burmese snub-nosed monkey - (species) D
Rhinopithecus bieti
black snub-nosed monkey - (species) D
RNASE4
Rhinopithecus strykeri
Burmese snub-nosed monkey - (species)
Rhinopithecus bieti
black snub-nosed monkey - (species)
Published - Accepted by Curator
RNASE4 [likely pseudo-replicate of other RNASE4 entry by introgression]
High-altitude adaptation (enhanced angiogenesis)
2 Mutations:
Coding
SNP
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
Interspecific
Association Mapping
Yu L; Wang GD; Ruan J ; et al. (2016)
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to hig[...]
GP00001506
RNASE4
P34096
Physiology
2 mutations
Rhinopithecus brelichi
Gray snub-nosed monkey - (species)
Rhinopithecus roxellana
golden snub-nosed monkey - (species) D
RNASE4 [likely pseudo-replicate of other RNASE4 entry by introgression]
Rhinopithecus roxellana
golden snub-nosed monkey - (species)
Published - Accepted by Curator
RNF212
Recombination rate (male)
Coding,
SNP
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Sandor C; Li W; Coppieters W ; et al. (2012)
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
GP00001639
RNF212
Q495C1
Physiology
T>C p.P259S in exon 12 with reduction in Genome-wide recombination rate
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
RNF212
Bos taurus
cattle - (species)
Published - Accepted by Curator
RnrS
Xenobiotic resistance (gemcitabine ; female fertility)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
King EG; Kislukhin G; Walters KN ; et al. (2014)
Using Drosophila melanogaster to identify chemotherapy toxicity genes.
GP00001404
RnrS
P48592
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
RnrS
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Rp1-D
Pathogen resistance
Gene Amplification,
Complex Change
Zea mays
(species)
Domesticated
Candidate Gene
Collins N; Drake J; Ayliffe M ; et al. (1999)
Molecular characterization of the maize Rp1-D rust resistance haplotype and its mutants.
2 Additional References
GP00000998
Rp1-D
Q9SWU0
Physiology
Unequal crossing over between paralogues resulting in chimeric gene
Zea mays
(species)
Zea mays
(species)
Rp1-D
Zea mays
(species)
Published - Accepted by Curator
Rp3 cluster
Pathogen resistance
Unknown,
Unknown
Zea mays
(species)
Domesticated
Linkage Mapping
Webb CA; Richter TE; Collins NC ; et al. (2002)
Genetic and molecular characterization of the maize rp3 rust resistance locus.
GP00000999
rp3-1
Q6PW75
Physiology
unknown
Zea mays
(species)
Zea mays
(species)
Rp3 cluster
Zea mays
(species)
Published - Accepted by Curator
RPM1
Pathogen resistance
Gene Loss,
Indel
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Grant MR; McDowell JM; Sharpe AG ; et al. (1998)
Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis.
2 Additional References
GP00001000
RPM1
Q39214
Physiology
3.7kb indel with a null-state in the sensitive strains N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPM1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPM1
Pathogen resistance
Gene Loss,
Complex Change
N
Brassica napus
rape - (species)
Intraspecific
Linkage Mapping
Grant MR; McDowell JM; Sharpe AG ; et al. (1998)
Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis.
GP00001001
RPM1
Q39214
Physiology
deletion N
Brassica napus
rape - (species)
Brassica napus
rape - (species)
RPM1
Brassica napus
rape - (species)
Published - Accepted by Curator
RPP1
Hybrid incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; von Reth M; Bautor J ; et al. (2014)
Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]
1 Additional References
GP00001281
RPP1
F4J339
Physiology
complex
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1
Hybrid incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; von Reth M; Bautor J ; et al. (2014)
Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]
1 Additional References
GP00001282
RPP1
F4J339
Physiology
complex
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1-WsA
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Botella MA; Parker JE; Frost LN ; et al. (1998)
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]
GP00001002
RPP1
F4J339
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1-WsA
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1-WsB
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Botella MA; Parker JE; Frost LN ; et al. (1998)
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]
GP00001003
RPP1
F4J339
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1-WsB
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1-WsC
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Botella MA; Parker JE; Frost LN ; et al. (1998)
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]
GP00001004
RPP1
F4J339
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1-WsC
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP13
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Interspecific
Linkage Mapping
Rose LE; Bittner-Eddy PD; Langley CH ; et al. (2004)
The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsi[...]
GP00001005
RPP13
Q9M667
Physiology
Various haplotypes
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP13
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP2A-RPP2B
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sinapidou E; Williams K; Nott L ; et al. (2004)
Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in A[...]
GP00001006
RPP2A
P51407
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP2A-RPP2B
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP4
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
van der Biezen EA; Freddie CT; Kahn K ; et al. (2002)
Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]
GP00001007
RPP4
F4JNA9
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP4
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP5
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
van der Biezen EA; Freddie CT; Kahn K ; et al. (2002)
Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]
1 Additional References
GP00001008
RPP5
F4JNB7
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP5
Pathogen resistance
Gene Amplification,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Parker JE; Coleman MJ; Szabò V ; et al. (1997)
The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 re[...]
1 Additional References
GP00001009
RPP5
F4JNB7
Physiology
Partial duplication sufficient to increase resistance
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP8
Pathogen resistance
Coding,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
McDowell JM; Dhandaydham M; Long TA ; et al. (1998)
Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resi[...]
1 Additional References
GP00001010
RPP8
Q8W4J9
Physiology
Chimeric fusion of two paralogues followed by coding divergence
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP8
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS2
Pathogen resistance
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Mindrinos M; Katagiri F; Yu GL ; et al. (1994)
The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site [...]
GP00001011
RPS2
Q42484
Physiology
10bp insertion close to the 5' end causing a frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RPS2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS2
Pathogen resistance
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Caicedo AL; Schaal BA; Kunkel BN (1999)
Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.
GP00001012
RPS2
Q42484
Physiology
W235* due to G704A N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPS2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS4
Pathogen resistance
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009)
RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.
1 Additional References
GP00001013
RPS4
Q9XGM3
Physiology
5bp deletion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RPS4
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS5
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Henk AD; Warren RF; Innes RW (1999)
A new Ac-like transposon of Arabidopsis is associated with a deletion of the RPS5 disease resistance[...]
1 Additional References
GP00001014
RPS5
O64973
Physiology
Deletion N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPS5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RREB1
Body fat distribution (visceral)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001555
RREB1
Q92766
Physiology
C>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
RREB1
Homo sapiens
human - (species)
Published - Accepted by Curator
RRS1
Pathogen resistance
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009)
RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.
1 Additional References
GP00001015
RRS1
P0DKH5
Physiology
Premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RRS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RSF1
Sporulation efficiency
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Gerke J; Lorenz K; Cohen B (2009)
Genetic interactions between transcription factors cause natural variation in yeast.
GP00001016
HFR1
Q9FE22
Physiology
D181G
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
RSF1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RTA1
Xenobiotic resistance (citrinin)
Cis-regulatory,
Unknown
Saccharomyces paradoxus
(species) D
Domesticated
Association Mapping
Naranjo S; Smith JD; Artieri CG ; et al. (2015)
Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.
GP00001312
RTA1
P53047
Physiology
unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces paradoxus
(species) D
RTA1
Saccharomyces paradoxus
(species)
Published - Accepted by Curator
Rx1
Color vision (expression of SWS2b opsin)
Cis-regulatory,
Indel
Tramitichromis intermedius
(species)
Interspecific
Linkage Mapping
Schulte JE; O'Brien CS; Conte MA ; et al. (2014)
Interspecific variation in Rx1 expression controls opsin expression and causes visual system diversi[...]
GP00001441
rx1
O42356
Physiology
413bp deletion located 2.5-kb upstream of the Rx1 translation start site correlating with decreased Rx1 expression
Aulonocara baenschi
Nkhomo-benga peacock cichlid - (species)
Tramitichromis intermedius
(species)
Rx1
Tramitichromis intermedius
(species)
Published - Accepted by Curator
RXFP2
Horns absence
Somatic sex change
Gene Amplification,
Insertion
Ovis aries
sheep - (species)
Domesticated
Linkage Mapping
Johnston SE; Gratten J; Berenos C ; et al. (2013)
Life history trade-offs at a single locus maintain sexually selected genetic variation.
1 Additional References
GP00001019
RXFP2
Q8WXD0
Morphology
Physiology
1833-bp genomic insertion located in the 3'-UTR region of RXFP2
Ovis aries
sheep - (species)
Ovis aries
sheep - (species)
RXFP2
Ovis aries
sheep - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Troczka B; Zimmer CT; Elias J ; et al. (2012)
Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...]
2 Additional References
GP00002433
RyR
Q24498
Physiology
G4946E
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Troczka B; Zimmer CT; Elias J ; et al. (2012)
Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...]
1 Additional References
GP00002434
RyR
Q24498
Physiology
G4946E due to GGG>GAA
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Steinbach D; Moritz G ; et al. (2017)
Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...]
1 Additional References
GP00002435
RyR
Q24498
Physiology
G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Steinbach D; Moritz G ; et al. (2017)
Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...]
1 Additional References
GP00002436
RyR
Q24498
Physiology
G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Douris V; Papapostolou KM; Ilias A ; et al. (2017)
Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]
1 Additional References
GP00002438
RyR
Q24498
Physiology
G4903V corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Douris V; Papapostolou KM; Ilias A ; et al. (2017)
Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]
1 Additional References
GP00002439
RyR
Q24498
Physiology
I4790M
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Guo L; Liang P; Zhou X ; et al. (2014)
Novel mutations and mutation combinations of ryanodine receptor in a chlorantraniliprole resistant p[...]
GP00002605
RyR
Q24498
Physiology
E1338D Q4594L I4790M)in highly conserved regions of RyR.
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Gong W; Yan HH; Gao L ; et al. (2014)
Chlorantraniliprole resistance in the diamondback moth (Lepidoptera: Plutellidae).
GP00002609
RyR
Q24498
Physiology
14 amino acid (Q4546-S4559) deletion. RyR transcript levels are lower in resistant strains than in susceptible strains. N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Yao R; Zhao DD; Zhang S ; et al. (2017)
Monitoring and mechanisms of insecticide resistance in Chilo suppressalis (Lepidoptera: Crambidae), [...]
1 Additional References
GP00002626
RyR
Q24498
Physiology
G4946E
Chilo suppressalis
striped riceborer - (species)
Chilo suppressalis
striped riceborer - (species) D
RYR
Chilo suppressalis
striped riceborer - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Wei Y; Yan R; Zhou Q ; et al. (2019)
Monitoring and Mechanisms of Chlorantraniliprole Resistance in Chilo suppressalis (Lepidoptera: Cram[...]
GP00002627
RyR
Q24498
Physiology
I4758M
Chilo suppressalis
striped riceborer - (species)
Chilo suppressalis
striped riceborer - (species) D
RYR
Chilo suppressalis
striped riceborer - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Candidate Gene
Zuo YY; Ma HH; Lu WJ ; et al. (2020)
Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide[...]
2 Additional References
GP00002633
RyR
Q24498
Physiology
I4743M - corresponds to I4790M in PxRyR
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
RYR
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
RYR1
Meat content
Coding,
SNP
Sus scrofa
pig - (species) D
Domesticated
Linkage Mapping
Fujii J; Otsu K; Zorzato F ; et al. (1991)
Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.
GP00002338
Ryr1
E9PZQ0
Physiology
p.R615C
Sus scrofa
pig - (species)
Sus scrofa
pig - (species) D
RYR1
Sus scrofa
pig - (species)
Published - Accepted by Curator
S5
Hybrid incompatibility (F1 female sterility)
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Chen J; Ding J; Ouyang Y ; et al. (2008)
A triallelic system of S5 is a major regulator of the reproductive barrier and compatibility of indi[...]
GP00001020
GRXS5
Q5QLR2
Physiology
2 non-synonymous changes Leu273Phe and Val471Ala segregate perfectly between japonica (Leu-Val) and japonica (Phe-Ala) - the effect of each amino acid chaeg has not been tested
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
S5
Oryza sativa
rice - (species)
Published - Accepted by Curator
S5 (ORF3-ORF4-ORF5 gene complex)
Hybrid incompatibility (sterility)
Coding,
Complex Change
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Yang J; Zhao X; Cheng K ; et al. (2012)
A killer-protector system regulates both hybrid sterility and segregation distortion in rice.
GP00001021
GRXS5
Q5QLR2
Physiology
System of alleles at three linked genes resulting in killer-protector system (hybrid incompabilitites)
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
S5 (ORF3-ORF4-ORF5 gene complex)
Oryza sativa
rice - (species)
Published - Accepted by Curator
sage
Silk yield
Cis-regulatory,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Xia Q; Guo Y; Zhang Z ; et al. (2009)
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).
GP00002410
sage
Q9VHG3
Physiology
Increased expression in high yield strains. The sage gene encodes a transcription factor that activates glue genes in salivary glands of Drosophila melanogaster.
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
sage
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
SaM + SaF
Hybrid incompatibility (F1 male sterility)
Unknown,
Unknown
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Long Y; Zhao L; Niu B ; et al. (2008)
Hybrid male sterility in rice controlled by interaction between divergent alleles of two adjacent ge[...]
1 Additional References
GP00001022
SaF+
B6RRX2
Physiology
Intron structure + aa changes on two adjacent coding genes
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
SaM + SaF
Oryza sativa
rice - (species)
Published - Accepted by Curator
SAP-2
Xenobiotic resistance (insecticide; pyrethroid)
Cis-regulatory,
Unknown
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Ingham VA; Anthousi A; Douris V ; et al. (2020)
A sensory appendage protein protects malaria vectors from pyrethroids.
GP00002432
SAP-2
Q6H8Z3
Physiology
The gene is highly overexpressed in the appendages of pyrethroid-resistant mosquitoes and its expression is further induced by insecticide exposure. Silencing of SAP2 almost completely restored susceptibility to the pyrethroid deltamethrin and also significantly increased the susceptibility to the other two pyrethroids (permethrin and alpha-cypermethrin).
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
SAP-2
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
scd-2
Diapause
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Reiner DJ; Ailion M; Thomas JH ; et al. (2008)
C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]
GP00001026
scd-2
O76411
Physiology
Gly985Arg
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
scd-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Mya arenaria
(species) D
Intraspecific
Candidate Gene
Bricelj VM; Connell L; Konoki K ; et al. (2005)
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.
GP00000721
SCN4A
P35499
Physiology
E945D
Mya arenaria
(species)
Mya arenaria
(species) D
SCN4A (Nav1.4)
Mya arenaria
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Erythrolamprus epinephelus
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
1 Additional References
GP00000724
SCN4A
P35499
Physiology
G1569D in DIV domain and D1568S in DIV domain with D1568S supposed to increase the resistance - exact causing mutation(s) unknown
Erythrolamprus poecilogyrus
(species)
Erythrolamprus epinephelus
(species) D
SCN4A (Nav1.4)
Erythrolamprus epinephelus
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Rhabdophis tigrinus
Tiger keelback - (species) D
Interspecific
Candidate Gene
Feldman CR; Brodie ED; Brodie ED ; et al. (2012)
Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.
1 Additional References
GP00000725
SCN4A
P35499
Physiology
I1555M
Thamnophis elegans
Western terrestrial garter snake - (species)
Rhabdophis tigrinus
Tiger keelback - (species) D
SCN4A (Nav1.4)
Rhabdophis tigrinus
Tiger keelback - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis atratus
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
1 Additional References
GP00000726
SCN4A
P35499
Physiology
D1277E in DIII domain
Thamnophis couchii
(species)
Thamnophis atratus
(species) D
SCN4A (Nav1.4)
Thamnophis atratus
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis atratus
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
1 Additional References
GP00000727
SCN4A
P35499
Physiology
D1568N in DIV domain
Thamnophis couchii
(species)
Thamnophis atratus
(species) D
SCN4A (Nav1.4)
Thamnophis atratus
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis couchii
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
1 Additional References
GP00000728
SCN4A
P35499
Physiology
M1276T in DIII domain
Thamnophis atratus
(species)
Thamnophis couchii
(species) D
SCN4A (Nav1.4)
Thamnophis couchii
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Hebius pryeri
Pryer's keelback - (species) D
Interspecific
Candidate Gene
Feldman CR; Brodie ED; Brodie ED ; et al. (2012)
Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes.
1 Additional References
GP00000729
SCN4A
P35499
Physiology
D1227E = D945E in DIII domain
Hebius vibakari
Japanese keelback - (species)
Hebius pryeri
Pryer's keelback - (species) D
SCN4A (Nav1.4)
Hebius pryeri
Pryer's keelback - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species)
Intraspecific
Candidate Gene
Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005)
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction.
1 Additional References
GP00000730
SCN4A
P35499
Physiology
G1566A in DIV domain
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species)
SCN4A (Nav1.4)
Thamnophis sirtalis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species)
Intraspecific
Candidate Gene
Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005)
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction.
1 Additional References
GP00000731
SCN4A
P35499
Physiology
I1561V in DIV domain
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species)
SCN4A (Nav1.4)
Thamnophis sirtalis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species)
Intraspecific
Candidate Gene
Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005)
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction.
1 Additional References
GP00000732
SCN4A
P35499
Physiology
I1556L and/or D1568N and/or G1569V
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species)
SCN4A (Nav1.4)
Thamnophis sirtalis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Mantella aurantiaca
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001573
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Mantella aurantiaca
(species) D
SCN4A (Nav1.4)
Mantella aurantiaca
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001574
SCN4A
P35499
Physiology
T>G p.S429A in DI-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001575
SCN4A
P35499
Physiology
A>G p.I433V in DI-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Dendrobates tinctorius
dyeing poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001576
SCN4A
P35499
Physiology
A>G p.I433V in DI-S6 domain
Anura
frogs and toads - (order)
Dendrobates tinctorius
dyeing poison frog - (species) D
SCN4A (Nav1.4)
Dendrobates tinctorius
dyeing poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Excidobates captivus
Rio Santiago poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001577
SCN4A
P35499
Physiology
A>G p.I433V in DI-S6 domain
Anura
frogs and toads - (order)
Excidobates captivus
Rio Santiago poison frog - (species) D
SCN4A (Nav1.4)
Excidobates captivus
Rio Santiago poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001578
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Dendrobates tinctorius
dyeing poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001579
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Dendrobates tinctorius
dyeing poison frog - (species) D
SCN4A (Nav1.4)
Dendrobates tinctorius
dyeing poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Excidobates captivus
Rio Santiago poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001580
SCN4A
P35499
Physiology
CC>AA p.A446E in DI-S6 domain
Anura
frogs and toads - (order)
Excidobates captivus
Rio Santiago poison frog - (species) D
SCN4A (Nav1.4)
Excidobates captivus
Rio Santiago poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Ameerega parvula
ruby poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001581
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Ameerega parvula
ruby poison frog - (species) D
SCN4A (Nav1.4)
Ameerega parvula
ruby poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Epipedobates
phantasmal poison frogs - (genus) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001582
SCN4A
P35499
Physiology
C>A p.A446D in DI-S6 domain
Anura
frogs and toads - (order)
Epipedobates
phantasmal poison frogs - (genus) D
SCN4A (Nav1.4)
Epipedobates
phantasmal poison frogs - (genus)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates
(genus) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001583
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Phyllobates
(genus) D
SCN4A (Nav1.4)
Phyllobates
(genus)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Dendrobates tinctorius
dyeing poison frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001584
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Dendrobates tinctorius
dyeing poison frog - (species) D
SCN4A (Nav1.4)
Dendrobates tinctorius
dyeing poison frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Hyloxalus italoi
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001585
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Hyloxalus italoi
(species) D
SCN4A (Nav1.4)
Hyloxalus italoi
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Ameerega
(genus) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001586
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Ameerega
(genus) D
SCN4A (Nav1.4)
Ameerega
(genus)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Silverstoneia flotator
rainforest rocket frog - (species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001587
SCN4A
P35499
Physiology
G>A p.V1583I in DIV-S6 domain
Anura
frogs and toads - (order)
Silverstoneia flotator
rainforest rocket frog - (species) D
SCN4A (Nav1.4)
Silverstoneia flotator
rainforest rocket frog - (species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (poison frog alkaloids)
Coding,
SNP
Phyllobates terribilis
(species) D
Intergeneric or Higher
Candidate Gene
Tarvin RD; Santos JC; O'Connell LA ; et al. (2016)
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison [...]
GP00001588
SCN4A
P35499
Physiology
C>A p.N1584T in DIV-S6 domain
Anura
frogs and toads - (order)
Phyllobates terribilis
(species) D
SCN4A (Nav1.4)
Phyllobates terribilis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)
Xenobiotic resistance (TTX)
Coding,
SNP
Takifugu rubripes
torafugu - (species)
Interspecific
Candidate Gene
Venkatesh B; Lu SQ; Dandona N ; et al. (2005)
Genetic basis of tetrodotoxin resistance in pufferfishes.
GP00000722
SCN4A
P35499
Physiology
Y401N
Teleostei
teleost fishes - (infraclass)
Takifugu rubripes
torafugu - (species)
SCN4A (Nav1.4a gene copy)
Takifugu rubripes
torafugu - (species)
Published - Accepted by Curator
SCN4A (Nav1.4a gene copy)
Xenobiotic resistance (TTX)
Coding,
SNP
Tetraodon nigroviridis
spotted green pufferfish - (species)
Interspecific
Candidate Gene
Venkatesh B; Lu SQ; Dandona N ; et al. (2005)
Genetic basis of tetrodotoxin resistance in pufferfishes.
GP00000723
SCN4A
P35499
Physiology
Y401C
Teleostei
teleost fishes - (infraclass)
Tetraodon nigroviridis
spotted green pufferfish - (species)
SCN4A (Nav1.4a gene copy)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)
Xenobiotic resistance (TTX)
Coding,
SNP
Tetraodon nigroviridis
spotted green pufferfish - (species)
Interspecific
Candidate Gene
Venkatesh B; Lu SQ; Dandona N ; et al. (2005)
Genetic basis of tetrodotoxin resistance in pufferfishes.
1 Additional References
GP00000733
SCN4A
P35499
Physiology
E945D
Teleostei
teleost fishes - (infraclass)
Tetraodon nigroviridis
spotted green pufferfish - (species)
SCN4A (Nav1.4b gene copy)
Tetraodon nigroviridis
spotted green pufferfish - (species)
Published - Accepted by Curator
SCN4A (Nav1.4b gene copy)
Xenobiotic resistance (TTX)
Coding,
SNP
Takifugu rubripes
torafugu - (species)
Interspecific
Candidate Gene
Jost MC; Hillis DM; Lu Y ; et al. (2008)
Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.
GP00000734
SCN4A
P35499
Physiology
M1240T
Teleostei
teleost fishes - (infraclass)
Takifugu rubripes
torafugu - (species)
SCN4A (Nav1.4b gene copy)
Takifugu rubripes
torafugu - (species)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Viperidae
(family) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001652
SCN8A
A0A1B0Z7A5
Physiology
I1709V in DIV (2x resistance)
Protobothrops flavoviridis
(species)
Viperidae
(family) D
SCN8A (Nav1.6)
Viperidae
(family)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Micrurus fulvius
eastern coral snake - (species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001653
SCN8A
A0A1B0Z7H0
Physiology
I1709V in DIV domain (2x resistance)
Naja kaouthia
monocled cobra - (species)
Micrurus fulvius
eastern coral snake - (species) D
SCN8A (Nav1.6)
Micrurus fulvius
eastern coral snake - (species)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Elapsoidea nigra
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001654
SCN8A
A0A1B0Z7G3
Physiology
I1709V in DIV domain (2x resistance)
Naja kaouthia
monocled cobra - (species)
Elapsoidea nigra
(species) D
SCN8A (Nav1.6)
Elapsoidea nigra
(species)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Erythrolamprus epinephelus
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001655
SCN8A
A0A1B0Z7B3
Physiology
G1717M in DIV domain (not tested)
Erythrolamprus poecilogyrus
(species)
Erythrolamprus epinephelus
(species) D
SCN8A (Nav1.6)
Erythrolamprus epinephelus
(species)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Lygophis anomalus
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001656
SCN8A
A0A1B0Z7F2
Physiology
V1709I (reversion) in DIV domain (loss of resistance)
Helicops angulatus
(species)
Lygophis anomalus
(species) D
SCN8A (Nav1.6)
Lygophis anomalus
(species)
Published - Accepted by Curator
SCN8A (Nav1.6)
Xenobiotic resistance (TTX)
Coding,
SNP
Natricinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001657
SCN8A
A0A1B0Z7B0
Physiology
V1709I (reversion) in DIV (loss of resistance)
Hebius pryeri
Pryer's keelback - (species)
Natricinae
(subfamily) D
SCN8A (Nav1.6)
Natricinae
(subfamily)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Anilios bituberculatus
prong-snouted blind snake - (species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001643
SCN9A
Q15858
Physiology
M1392A in DIII domain (not tested)
Anolis carolinensis
green anole - (species)
Anilios bituberculatus
prong-snouted blind snake - (species) D
SCN9A (Nav1.7)
Anilios bituberculatus
prong-snouted blind snake - (species)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Henophidia
(superfamily) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001644
SCN9A
Q15858
Physiology
M1392T in DIII (15x resistance)
Anolis carolinensis
green anole - (species)
Henophidia
(superfamily) D
SCN9A (Nav1.7)
Henophidia
(superfamily)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Chrysemys picta
painted turtle - (species) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001645
SCN9A
Q15858
Physiology
D1393P (most probably E>P) in DIII domain (not tested)
Gallus gallus
chicken - (species)
Chrysemys picta
painted turtle - (species) D
SCN9A (Nav1.7)
Chrysemys picta
painted turtle - (species)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Carphophis
(genus) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001646
SCN9A
Q15858
Physiology
I1677V in DIV (2x resistance)
Diadophis punctatus
Ringneck snake - (species)
Carphophis
(genus) D
SCN9A (Nav1.7)
Carphophis
(genus)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Chrysemys picta
painted turtle - (species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001647
SCN9A
Q15858
Physiology
A1681G in DIV domain (1.5x resistance)
Gallus gallus
chicken - (species)
Chrysemys picta
painted turtle - (species) D
SCN9A (Nav1.7)
Chrysemys picta
painted turtle - (species)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Leptotyphlops
(genus) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001648
SCN9A
Q15858
Physiology
A1681G (1.5x resistance) in DIV
Anilios bituberculatus
prong-snouted blind snake - (species)
Leptotyphlops
(genus) D
SCN9A (Nav1.7)
Leptotyphlops
(genus)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Anolis carolinensis
green anole - (species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001649
SCN9A
Q15858
Physiology
D1684A (most probably N>A) in DIV domain (150x resistance)
Dopasia gracilis
Burmese glass lizard - (species)
Anolis carolinensis
green anole - (species) D
SCN9A (Nav1.7)
Anolis carolinensis
green anole - (species)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Epicrates cenchria
(species) D
Interspecific
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001650
SCN9A
Q15858
Physiology
D1684H (most probably N>H) in DIV domain (not tested)
Boa constrictor
boa - (species)
Epicrates cenchria
(species) D
SCN9A (Nav1.7)
Epicrates cenchria
(species)
Published - Accepted by Curator
SCN9A (Nav1.7)
Xenobiotic resistance (TTX)
Coding,
SNP
Leptotyphlops
(genus) D
Intergeneric or Higher
Candidate Gene
McGlothlin JW; Kobiela ME; Feldman CR ; et al. (2016)
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance.
GP00001651
SCN9A
Q15858
Physiology
G1685Y (not tested) in DIV
Anilios bituberculatus
prong-snouted blind snake - (species)
Leptotyphlops
(genus) D
SCN9A (Nav1.7)
Leptotyphlops
(genus)
Published - Accepted by Curator
SCR
Self-incompatibility (loss)
Coding,
Inversion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Tsuchimatsu T; Suwabe K; Shimizu-Inatsugi R ; et al. (2010)
Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene.
1 Additional References
GP00001271
SCRA
P0CG07
Physiology
213 bp inversion causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
SCR
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Sdic gene cluster
Fertility (sperm competition; sperm competence)
Gene Amplification,
Complex Change
Drosophila melanogaster
fruit fly - (species)
Interspecific
Candidate Gene
Nurminsky DI; Nurminskaya MV; De Aguiar D ; et al. (1998)
Selective sweep of a newly evolved sperm-specific gene in Drosophila.
1 Additional References
GP00001032
Sdic1
Q9W5W4
Physiology
Gene duplication
melanogaster subgroup
(species subgroup)
Drosophila melanogaster
fruit fly - (species)
Sdic gene cluster
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
sdY
Sex determination
Unknown,
Unknown
Teleostei
teleost fishes - (infraclass)
Interspecific
Linkage Mapping
Yano A; Guyomard R; Nicol B ; et al. (2012)
An immune-related gene evolved into the master sex-determining gene in rainbow trout, Oncorhynchus m[...]
GP00001033
sdy
I7GVT3
Physiology
Novel gene evolution by modification of the irf9 gene; unrelated to sex determination
Oncorhynchus mykiss
rainbow trout - (species)
Teleostei
teleost fishes - (infraclass)
sdY
Teleostei
teleost fishes - (infraclass)
Published - Accepted by Curator
se5
Flowering time
Coding,
Deletion
N
Oryza sativa
rice - (species) D
Domesticated
Linkage Mapping
Izawa T; Oikawa T; Tokutomi S ; et al. (2000)
Phytochromes confer the photoperiodic control of flowering in rice (a short-day plant).
GP00001034
HO1
Q69XJ4
Physiology
1bp deletion in exon 1; causes a frameshift and a premature stop codon N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
se5
Oryza sativa
rice - (species)
Published - Accepted by Curator
SELF PRUNING 5G (SP5G)
Flowering time
Cis-regulatory,
Unknown
Solanum lycopersicum
tomato - (species)
Domesticated
Linkage Mapping
Soyk S; Müller NA; Park SJ ; et al. (2017)
Variation in the flowering gene SELF PRUNING 5G promotes day-neutrality and early yield in tomato.
GP00001564
SP5G
Q84XK9
Physiology
several candidate SNPs and structural variants
Solanum pimpinellifolium
(species)
Solanum lycopersicum
tomato - (species)
SELF PRUNING 5G (SP5G)
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
Serine/threonine protein kinase RIM15
Nitrogen use (growth efficiency)
Coding,
Insertion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001500
RIM15
P43565
Physiology
2 bp insertion 459_460insCA shifting the reading frame to cause an early stop codon (null allele) N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Serine/threonine protein kinase RIM15
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
SG3/At4g30720
Growth (shoots)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Vlad D; Rappaport F; Simon M ; et al. (2010)
Gene transposition causing natural variation for growth in Arabidopsis thaliana.
GP00001036
PDE327
F4JQE2
Physiology
Premature stop codon at the SG3 locus in Bur-0 (a 1bp deletion in exon four of At4g30720 results in a frame shift; predicting a premature stop codon which terminates the ORF after 5 amino acids); but in this accession this gene has a functional copy at a N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
SG3/At4g30720
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
SGLT1
Starch processing
Coding,
Unknown
Canis lupus familiaris
dog - (subspecies)
Domesticated
Association Mapping
Axelsson E; Ratnakumar A; Arendt ML ; et al. (2013)
The genomic signature of dog domestication reveals adaptation to a starch-rich diet.
GP00001037
Slc5a1
Q9QXI6
Physiology
unknown
Canis lupus
gray wolf - (species)
Canis lupus familiaris
dog - (subspecies)
SGLT1
Canis lupus familiaris
dog - (subspecies)
Published - Accepted by Curator
Shattering1 - OsSh1
Seed shattering
Gene Loss,
Deletion
N
Oryza glaberrima
African rice - (species) D
Domesticated
Association Mapping
Wang M; Yu Y; Haberer G ; et al. (2014)
The genome sequence of African rice (Oryza glaberrima) and evidence for independent domestication.
GP00001038
YAB2
Q10FZ7
Physiology
45kb deletion resulting in complete removal of OsSh1 in O. glaberrima; resulting in seed abscission phenotype N
Oryza barthii
(species)
Oryza glaberrima
African rice - (species) D
Shattering1 - OsSh1
Oryza glaberrima
African rice - (species)
Published - Accepted by Curator
Shattering1 - OsSh1
Seed shattering
Unknown,
Insertion
Oryza sativa
rice - (species) D
Domesticated
Association Mapping
Lin Z; Li X; Shannon LM ; et al. (2012)
Parallel domestication of the Shattering1 genes in cereals.
2 Additional References
GP00001039
YAB2
Q10FZ7
Physiology
>4kb insertion in intron (unclear)
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Shattering1 - OsSh1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Shattering1 - Sh1
Seed shattering
Coding,
Deletion
N
Sorghum bicolor
sorghum - (species) D
Domesticated
Linkage Mapping
Lin Z; Li X; Shannon LM ; et al. (2012)
Parallel domestication of the Shattering1 genes in cereals.
GP00001040
YAB2
Q10FZ7
Physiology
2.2kb deletion at the location of exons 2 and 3 N
Sorghum virgatum
(species)
Sorghum bicolor
sorghum - (species) D
Shattering1 - Sh1
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
Shattering1 - Sh1
Seed shattering
Coding,
Complex Change
Sorghum bicolor
sorghum - (species)
Domesticated
Linkage Mapping
Lin Z; Li X; Shannon LM ; et al. (2012)
Parallel domestication of the Shattering1 genes in cereals.
GP00001041
YAB2
Q10FZ7
Physiology
two promoter variants at positions -1194 and -1185
Sorghum virgatum
(species)
Sorghum bicolor
sorghum - (species)
Shattering1 - Sh1
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
Shattering1 - Sh1
Seed shattering
Coding,
SNP
Sorghum bicolor
sorghum - (species)
Domesticated
Linkage Mapping
Lin Z; Li X; Shannon LM ; et al. (2012)
Parallel domestication of the Shattering1 genes in cereals.
GP00001042
YAB2
Q10FZ7
Physiology
GT-to-GG splice-site variant
Sorghum virgatum
(species)
Sorghum bicolor
sorghum - (species)
Shattering1 - Sh1
Sorghum bicolor
sorghum - (species)
Published - Accepted by Curator
Shattering1 - ZmSh1-1
Seed shattering
Coding,
Complex Change
Zea mays
(species)
Domesticated
Association Mapping
Lin Z; Li X; Shannon LM ; et al. (2012)
Parallel domestication of the Shattering1 genes in cereals.
GP00001043
YAB2
Q10FZ7
Physiology
complex structural variations
Zea mays
(species)
Zea mays
(species)
Shattering1 - ZmSh1-1
Zea mays
(species)
Published - Accepted by Curator
Shattering1 - ZmSh1-5.1 + ZmSh1-5.2
Seed shattering
Coding,
Unknown
Zea mays
(species)
Domesticated
Association Mapping
Lin Z; Li X; Shannon LM ; et al. (2012)
Parallel domestication of the Shattering1 genes in cereals.
GP00001044
YAB2
Q10FZ7
Physiology
various structural variations
Zea mays
(species)
Zea mays
(species)
Shattering1 - ZmSh1-5.1 + ZmSh1-5.2
Zea mays
(species)
Published - Accepted by Curator
shattering4 - sh4
Seed shattering
Cis-regulatory,
Unknown
Oryza glaberrima
African rice - (species) D
Domesticated
Association Mapping
Wang M; Yu Y; Haberer G ; et al. (2014)
The genome sequence of African rice (Oryza glaberrima) and evidence for independent domestication.
GP00001045
sh4
Q1PIH9
Physiology
several candidate mutations: ten SNPs and five small insertion/deletions leading to reduced expression
Oryza barthii
(species)
Oryza glaberrima
African rice - (species) D
shattering4 - sh4
Oryza glaberrima
African rice - (species)
Published - Accepted by Curator
shattering4 - sh4
Seed shattering
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Li C; Zhou A; Sang T (2006)
Rice domestication by reducing shattering.
GP00001046
sh4
Q1PIH9
Physiology
Asn -> Lys
Oryza rufipogon
(species)
Oryza sativa
rice - (species)
shattering4 - sh4
Oryza sativa
rice - (species)
Published - Accepted by Curator
shrunken-2 (Sh2) = endosperm ADP-glucose pyrophosphorylase large subunit
Feather
Cis-regulatory,
Insertion
Zea mays
(species) D
Domesticated
Linkage Mapping
Preiss J; Danner S; Summers PS ; et al. (1990)
Molecular Characterization of the Brittle-2 Gene Effect on Maize Endosperm ADPglucose Pyrophosphoryl[...]
1 Additional References
GP00001050
SH2
P55241
Physiology
insertion of the transposable element Dissociation
Zea mays
(species)
Zea mays
(species) D
shrunken-2 (Sh2) = endosperm ADP-glucose pyrophosphorylase large subunit
Zea mays
(species)
Published - Accepted by Curator
sid-2
Immune response (RNAi efficiency)
Unknown,
Unknown
Caenorhabditis elegans
(species)
Interspecific
Candidate Gene
Winston WM; Sutherlin M; Wright AJ ; et al. (2007)
Caenorhabditis elegans SID-2 is required for environmental RNA interference.
GP00001051
sid-2
G5EEV9
Physiology
unknown
Caenorhabditis
(genus)
Caenorhabditis elegans
(species)
sid-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
SIGLEC13
Pathogen resistance
Gene Loss,
Complex Change
N
Homo sapiens
human - (species)
Interspecific
Candidate Gene
Wang X; Mitra N; Secundino I ; et al. (2012)
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
GP00001052
SIGLEC13
Q64JA4
Physiology
Gene deletion by Alu-mediated recombination N
Primates
(order)
Homo sapiens
human - (species)
SIGLEC13
Homo sapiens
human - (species)
Published - Accepted by Curator
SIGLEC17P (pseudogene)
Pathogen resistance
Coding,
Deletion
N
Homo sapiens
human - (species) D
Interspecific
Candidate Gene
Wang X; Mitra N; Secundino I ; et al. (2012)
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
GP00001053
SIGLEC13
Q64JA4
Physiology
1bp deletion resulting in frame-shift (pseudogenization) N
Primates
(order)
Homo sapiens
human - (species) D
SIGLEC17P (pseudogene)
Homo sapiens
human - (species)
Published - Accepted by Curator
SIR2
Longevity
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Gresham D; Desai MM; Tucker CM ; et al. (2008)
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]
GP00001054
SIR2
P06700
Physiology
1 to 5 amino-acid substitutions
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
SIR2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
SKC1 =OsHKT1
Salt tolerance
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Ren ZH; Gao JP; Li LG ; et al. (2005)
A rice quantitative trait locus for salt tolerance encodes a sodium transporter.
GP00001055
HKT8
A2WNZ9
Physiology
several candidate missense mutations
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
SKC1 =OsHKT1
Oryza sativa
rice - (species)
Published - Accepted by Curator
SLB1/2
Pathogen resistance (Root parasitic plant) (root parasitic plant)
Gene Loss,
Deletion
N
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Cardoso C; Zhang Y; Jamil M ; et al. (2014)
Natural variation of rice strigolactone biosynthesis is associated with the deletion of two MAX1 ort[...]
GP00001631
Os01g0700900
M9R6D3
Physiology
deletion of 2 cytochrome P450 genes (Os010700900 & Os01g0701400) N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
SLB1/2
Oryza sativa
rice - (species)
Published - Accepted by Curator
SLY41
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00001712
SLY41
P22215
Physiology
Trp253Leu (G>T at position 893332 according to Table 1)
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
SLY41
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
SMC3
Recombination rate (female)
Unknown,
Unknown
Bos taurus
cattle - (species)
Domesticated
Association Mapping
Ma L; O'Connell JR; VanRaden PM ; et al. (2015)
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
GP00001666
SMC3
O97594
Physiology
On chromosome 26. Associated SNP located upstream
Bos taurus
cattle - (species)
Bos taurus
cattle - (species)
SMC3
Bos taurus
cattle - (species)
Published - Accepted by Curator
SOD1
Xenobiotic resistance (paraquat)
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Vontas JG; Tsakas SC; Loukas M ; et al. (2001)
Low-activity allele of copper-zinc superoxide dismutase (CuZnSOD) in Drosophila increases paraquat g[...]
GP00001985
Sod1
P61851
Physiology
Insertion of a 0.68kb truncated P-element 47bp downstream of the transcription start site.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
SOD1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SOD3
Oxidative stress resistance
Blood pressure
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001380
SOD3
P08294
Physiology
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
SOD3
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
spineless (ss)
Color vision (eye; photoreceptor composition)
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Anderson C; Reiss I; Zhou C ; et al. (2017)
Natural variation in stochastic photoreceptor specification and color preference in Drosophila.
GP00001987
ss
E1JIM6
Physiology
Single base insertion in the ss regulatory region upstream of the ss transcription start site. The insertion affects the stochastic on/off expression of the ss protein seen in the R7 photoreceptors: the presence of the insertion results in a significant decrease in the ratio of ss expressing to non-expressing R7 cells.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
spineless (ss)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
squalene synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001947
FDFT1
P37268
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
squalene synthase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
squalene synthase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Kurzchalia TV; Ward S (2003)
Why do worms need cholesterol?
1 Additional References
GP00001948
FDFT1
P37268
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
squalene synthase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SR-CII
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sackton TB; Clark AG (2006)
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
GP00001071
Sr-CII
Q5ELW9
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
SR-CII
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SRF3
Hybrid Incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; García AV; Kronholm I ; et al. (2010)
Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...]
1 Additional References
GP00001072
SRF3
Q6R2K3
Physiology
Complex haplotype
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
SRF3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
SRF3
Hybrid Incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; García AV; Kronholm I ; et al. (2010)
Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...]
1 Additional References
GP00001073
SRF3
Q6R2K3
Physiology
Complex haplotype
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
SRF3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
srg-34
Diapause (resistance to dauer-inducing pheromone)
Gene Loss,
Deletion
N
Caenorhabditis briggsae
(species)
Domesticated
Linkage Mapping
McGrath PT; Xu Y; Ailion M ; et al. (2011)
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
GP00001074
srg-34
Q9XXQ5
Physiology
33kb deletion N
Caenorhabditis briggsae
(species)
Caenorhabditis briggsae
(species)
srg-34
Caenorhabditis briggsae
(species)
Published - Accepted by Curator
srg-36/37
Diapause (resistance to dauer-inducing pheromone)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species)
Domesticated
Linkage Mapping
McGrath PT; Xu Y; Ailion M ; et al. (2011)
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
GP00001075
srg-34
Q9XXQ5
Physiology
6795bp deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
srg-36/37
Caenorhabditis elegans
(species)
Published - Accepted by Curator
srg-36/37
Diapause (resistance to dauer-inducing pheromone)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species)
Domesticated
Linkage Mapping
McGrath PT; Xu Y; Ailion M ; et al. (2011)
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
GP00001076
srg-34
Q9XXQ5
Physiology
4906bp deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
srg-36/37
Caenorhabditis elegans
(species)
Published - Accepted by Curator
SRGAP2
Neuronal maturation
Gene Amplification,
Complex Change
Primates
(order)
Intergeneric or Higher
Candidate Gene
Charrier C; Joshi K; Coutinho-Budd J ; et al. (2012)
Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation[...]
1 Additional References
GP00001077
Srgap2
Q91Z67
Physiology
Partial duplications (negative alleles)
Homo sapiens
human - (species)
Primates
(order)
SRGAP2
Primates
(order)
Published - Accepted by Curator
srx-43
Pheromone response (ascaroside)
Cis-regulatory,
Unknown
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Greene JS; Brown M; Dobosiewicz M ; et al. (2016)
Balancing selection shapes density-dependent foraging behaviour.
1 Additional References
GP00001319
srx-43
O45767
Physiology
unknown
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
srx-43
Caenorhabditis elegans
(species)
Published - Accepted by Curator
srx-44
Pheromone response (ascaroside)
Cis-regulatory,
Unknown
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Greene JS; Dobosiewicz M; Butcher RA ; et al. (2016)
Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foragin[...]
1 Additional References
GP00001504
srx-43
O45767
Physiology
Phenotypic change mapped to a small region located between 34bp and 72 bp upstream of the srx-44 start codon. This DNA region contains 9 changes between N2 strain and MY14 strain.
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
srx-44
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Starch branching enzyme (SBEI) = rugosus (R)
Starch structure
Seed aspect
Coding,
Insertion
N
Pisum sativum
pea - (species) D
Domesticated
Linkage Mapping
Bhattacharyya MK; Smith AM; Ellis TH ; et al. (1990)
The wrinkled-seed character of pea described by Mendel is caused by a transposon-like insertion in a[...]
GP00001078
SBEI
Q41058
Physiology
Morphology
800 bp TE insertion; probably disrupts the last 61 amino acids of the SBEI protein N
Pisum sativum
pea - (species)
Pisum sativum
pea - (species) D
Starch branching enzyme (SBEI) = rugosus (R)
Pisum sativum
pea - (species)
Published - Accepted by Curator
StCDF1
Latitudinal adaptation
Coding,
Insertion
N
Solanum tuberosum
potato - (species) D
Domesticated
Linkage Mapping
Kloosterman B; Abelenda JA; Gomez Mdel M ; et al. (2013)
Naturally occurring allele diversity allows potato cultivation in northern latitudes.
GP00001079
CDF1
Q8W1E3
Physiology
+7bp insertion resulting in frameshift and truncated protein N
Solanum tuberosum
potato - (species)
Solanum tuberosum
potato - (species) D
StCDF1
Solanum tuberosum
potato - (species)
Published - Accepted by Curator
StCDF1
Latitudinal adaptation
Coding,
Insertion
Solanum tuberosum
potato - (species) D
Domesticated
Linkage Mapping
Kloosterman B; Abelenda JA; Gomez Mdel M ; et al. (2013)
Naturally occurring allele diversity allows potato cultivation in northern latitudes.
GP00001080
CDF1
Q8W1E3
Physiology
865bp insertion leading to a fusion protein
Solanum tuberosum
potato - (species)
Solanum tuberosum
potato - (species) D
StCDF1
Solanum tuberosum
potato - (species)
Published - Accepted by Curator
sterol C5 desaturase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001953
ERG3
P32353
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Drosophila melanogaster
fruit fly - (species) D
sterol C5 desaturase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
sterol C5 desaturase
Cholesterol metabolism (cholesterol biosynthesis)
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intergeneric or Higher
Candidate Gene
Vinci G; Xia X; Veitia RA (2008)
Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.
GP00001954
ERG3
P32353
Physiology
gene absent in the genome N
Homo sapiens
human - (species)
Caenorhabditis elegans
(species) D
sterol C5 desaturase
Caenorhabditis elegans
(species)
Published - Accepted by Curator
str-217
Xenobiotic resistance (insecticide; DEET)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Candidate Gene
Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018)
A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.
GP00001783
str-217
Q9XX85
Physiology
deletion that leads to a predicted frame shift and early stop codon - the predicted resulting protein has only one transmembrane domain instead of the 7 transmembrane domains - 138-bp deletion in exon 2 and 3 and intervening intron according to https://www.wormbase.org/species/c_elegans/variation/WBVar02076179#02-45-3 and email from Emily Dennis from 9 March 2019 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
str-217
Caenorhabditis elegans
(species)
Published - Accepted by Curator
str-217
Xenobiotic resistance (insecticide; DEET)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Candidate Gene
Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018)
A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.
GP00001784
str-217
Q9XX85
Physiology
on chromosome V position 17000292 G>A stop_gained 13C>T - Gln5* N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
str-217
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Style2.1
Flower morphology (style length)
Autogamy
Cis-regulatory,
Unknown
Solanum lycopersicum
tomato - (species) D
Domesticated
Linkage Mapping
Chen KY; Cong B; Wing R ; et al. (2007)
Changes in regulation of a transcription factor lead to autogamy in cultivated tomatoes.
GP00001081
100301942
B6CG44
Morphology
Physiology
Not identified
Solanum pennellii
(species)
Solanum lycopersicum
tomato - (species) D
Style2.1
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
sugary 1 (su1) = isoamylase-type starch-debranching enzymes
Fruit sugar content
Coding,
SNP
Zea mays
(species)
Domesticated
Candidate Gene
Dinges JR; Colleoni C; Myers AM ; et al. (2001)
Molecular structure of three mutations at the maize sugary1 locus and their allele-specific phenotyp[...]
1 Additional References
GP00001082
sugary1
O22637
Physiology
F163L and/or W578R; W738R is more likely to be the mutation responsible as it affect a residue conserved in plants and bacteria
Zea mays
(species)
Zea mays
(species)
sugary 1 (su1) = isoamylase-type starch-debranching enzymes
Zea mays
(species)
Published - Accepted by Curator
SUL1
Low-sulfate adaptation (experimental evolution)
Gene Amplification,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species)
Experimental Evolution
Association Mapping
Gresham D; Desai MM; Tucker CM ; et al. (2008)
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]
1 Additional References
GP00001083
SUL1
P38359
Physiology
out of 16 lines; 15 distinct SUL1 amplification alleles evolved. Copy number ranged from 2 to 16 ; Amplicon size ranged from 2.5kb to 40kb
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
SUL1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
sulfate transporter 1;1
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001429
SULTR1;1
Q9SAY1
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
sulfate transporter 1;1
Arabidopsis arenosa
(species)
Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)
Xenobiotic resistance (oxamniquine)
Coding,
Deletion
Schistosoma mansoni
(species) D
Intraspecific
Linkage Mapping
Valentim CL; Cioli D; Chevalier FD ; et al. (2013)
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]
GP00001470
SULT-OR
G4VLE5
Physiology
E142del
Schistosoma mansoni
(species)
Schistosoma mansoni
(species) D
Sulfotransferase-OXA-Resistance (SULT-OR)
Schistosoma mansoni
(species)
Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)
Xenobiotic resistance (oxamniquine)
Coding,
SNP
Schistosoma mansoni
(species) D
Intraspecific
Linkage Mapping
Valentim CL; Cioli D; Chevalier FD ; et al. (2013)
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]
GP00001471
SULT-OR
G4VLE5
Physiology
C35R (T>C)
Schistosoma mansoni
(species)
Schistosoma mansoni
(species) D
Sulfotransferase-OXA-Resistance (SULT-OR)
Schistosoma mansoni
(species)
Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)
Xenobiotic resistance (oxamniquine)
Coding,
SNP
Schistosoma mansoni
(species)
Intraspecific
Candidate Gene
Valentim CL; Cioli D; Chevalier FD ; et al. (2013)
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]
GP00001472
SULT-OR
G4VLE5
Physiology
F39 Sm > Y54 Sh (T>A) TTT>TAT
Schistosoma mansoni
(species)
Schistosoma mansoni
(species)
Sulfotransferase-OXA-Resistance (SULT-OR)
Schistosoma mansoni
(species)
Published - Accepted by Curator
SVP (SHORT VEGETATIVE PHASE)
Flowering time
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Méndez-Vigo B; Martínez-Zapater JM; Alonso-Blanco C (2013)
The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic [...]
GP00001087
SVP
Q9FVC1
Physiology
Ala32Val
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
SVP (SHORT VEGETATIVE PHASE)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
SWS2
Xenobiotic resistance (alcohol, ethanol)
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Swinnen S; Schaerlaekens K; Pais T ; et al. (2012)
Identification of novel causative genes determining the complex trait of high ethanol tolerance in y[...]
GP00001088
SWS2
P53937
Physiology
unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
SWS2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
SWS2
Sporulation efficiency
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Ben-Ari G; Zenvirth D; Sherman A ; et al. (2006)
Four linked genes participate in controlling sporulation efficiency in budding yeast.
GP00001089
SWS2
P53937
Physiology
unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
SWS2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Linkage Mapping
Coste A; Turner V; Ischer F ; et al. (2006)
A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of hetero[...]
GP00001090
TAC1
A7IZW4
Physiology
N977D
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance
Gene Amplification,
Complex Change
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001091
TAC1
A7IZW4
Physiology
Copy number Variant
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance
Coding,
Deletion
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001092
TAC1
A7IZW4
Physiology
1a.a. deletion
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance
Coding,
Deletion
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001093
TAC1
A7IZW4
Physiology
7a.a. deletion
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001094
TAC1
A7IZW4
Physiology
G980E
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001095
TAC1
A7IZW4
Physiology
A736V
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001096
TAC1
A7IZW4
Physiology
T225A
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAF5
Low-glucose adaptation (experimental evolution)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Kao KC; Sherlock G (2008)
Molecular characterization of clonal interference during adaptive evolution in asexual populations o[...]
1 Additional References
GP00001710
TAF5
P38129
Physiology
Gly693Val (G>T at position 616441 according to Table 1) - GGN to GTN position 616441
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
TAF5
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
TAO3
Sporulation efficiency
Cis-regulatory,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Deutschbauer AM; Davis RW (2005)
Quantitative trait loci mapped to single-nucleotide resolution in yeast.
GP00001103
TAO3
P40468
Physiology
E1493Q
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
TAO3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
TaPHS1
Seed dormancy
Coding,
SNP
N
Triticum aestivum
bread wheat - (species)
Domesticated
Linkage Mapping
Liu S; Sehgal SK; Li J ; et al. (2013)
Cloning and characterization of a critical regulator for preharvest sprouting in wheat.
GP00001104
PHS1
D2J2Y0
Physiology
GT-to-AT transition at the 5_ donor splice site (position +646) of intron 3 AND Premature Stop Codon (position +666) N
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
TaPHS1
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
TAS1R1
Taste sensitivity (sugar)
Coding,
Unknown
Calypte anna
Anna's hummingbird - (species) D
Interspecific
Candidate Gene
Baldwin MW; Toda Y; Nakagita T ; et al. (2014)
Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancest[...]
GP00001307
T1R1
A0A088DBT6
Physiology
unknown
Gallus gallus
chicken - (species)
Calypte anna
Anna's hummingbird - (species) D
TAS1R1
Calypte anna
Anna's hummingbird - (species)
Published - Accepted by Curator
TAS1R1
Taste sensitivity (umami)
Coding,
Deletion
N
Ailurus fulgens
lesser panda - (species) D
Interspecific
Candidate Gene
Hu Y; Wu Q; Ma S ; et al. (2017)
Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas.
GP00001415
Tas1r1
Q99PG6
Physiology
1bp deletion (deletion of a C) in the sixth exon; N
Ursus maritimus
polar bear - (species)
Ailurus fulgens
lesser panda - (species) D
TAS1R1
Ailurus fulgens
lesser panda - (species)
Published - Accepted by Curator
TAS1R1
Taste sensitivity (umami)
Coding,
Deletion
N
Ailuropoda melanoleuca
giant panda - (species) D
Interspecific
Candidate Gene
Li R; Fan W; Tian G ; et al. (2010)
The sequence and de novo assembly of the giant panda genome.
2 Additional References
GP00001416
Tas1r1
Q99PG6
Physiology
pseudogene due to three indel mutations in the third and sixth exons. The giant panda has one 2-bp insertion on the third exon and two deletions (6-bp and 4-bp) on the sixth exon, N
Ursus maritimus
polar bear - (species)
Ailuropoda melanoleuca
giant panda - (species) D
TAS1R1
Ailuropoda melanoleuca
giant panda - (species)
Published - Accepted by Curator
TAS1R2
Taste sensitivity (sugar)
Coding,
Deletion
N
Felidae
cat family - (family) D
Intergeneric or Higher
Candidate Gene
Li X; Li W; Wang H ; et al. (2005)
Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar.
1 Additional References
GP00001109
TAS1R2
Q8TE23
Physiology
247bp deletion in exon 3 and stop codons in exons 4 and 6. N
Mammalia
mammals - (class)
Felidae
cat family - (family) D
TAS1R2
Felidae
cat family - (family)
Published - Accepted by Curator
TAS1R3
Taste sensitivity (sugar)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Linkage Mapping
Max M; Shanker YG; Huang L ; et al. (2001)
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.
1 Additional References
GP00001110
TAS1R3
Q7RTX0
Physiology
I60T; is predicted to introduce a novel N-linked glycosylation site which might interfere with receptor dimerization
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
TAS1R3
Mus musculus
house mouse - (species)
Published - Accepted by Curator
TAS1R3
Taste sensitivity (sugar)
Coding,
SNP
Calypte anna
Anna's hummingbird - (species) D
Interspecific
Candidate Gene
Baldwin MW; Toda Y; Nakagita T ; et al. (2014)
Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancest[...]
GP00001306
T1R3
A0A088DCH0
Physiology
19 nonconsecutive amino acids confer sugar responsiveness and they are confined to three different regions of the protein - change(s) in all 3 regions are required for the acquisition of sugar binding- The exact effect of each single amino acid change has not been tested
Gallus gallus
chicken - (species)
Calypte anna
Anna's hummingbird - (species) D
TAS1R3
Calypte anna
Anna's hummingbird - (species)
Published - Accepted by Curator
TAS2R38
Taste sensitivity (bitter)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Kim UK; Jorgenson E; Coon H ; et al. (2003)
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthioc[...]
1 Additional References
GP00001111
TAS2R38
P59533
Physiology
P49A and/or A262V and/or V296I
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TAS2R38
Homo sapiens
human - (species)
Published - Accepted by Curator
TAS2R38
Taste sensitivity (bitter)
Coding,
SNP
Pan troglodytes
chimpanzee - (species)
Intraspecific
Candidate Gene
Wooding S; Bufe B; Grassi C ; et al. (2006)
Independent evolution of bitter-taste sensitivity in humans and chimpanzees.
GP00001112
TAS2R38
P59533
Physiology
M1R; eliminates start codon; protein initiates at later Met. Protein apparently null for signalling
Pan troglodytes
chimpanzee - (species)
Pan troglodytes
chimpanzee - (species)
TAS2R38
Pan troglodytes
chimpanzee - (species)
Published - Accepted by Curator
Tehao
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sackton TB; Clark AG (2006)
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
GP00001115
Tehao
Q9VJX9
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Tehao
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
tetraspanin
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
SNP
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Association Mapping
Jin L; Wang J; Guan F ; et al. (2018)
Dominant point mutation in a tetraspanin gene associated with field-evolved resistance of cotton bol[...]
GP00002468
Tsp2A
O46101
Physiology
L31S due to a nucleotide substitution T92C. CRISPR knockout of the tetraspanin gene restored susceptibility to a resistant strain whereas inserting the mutation conferred 125-fold resistance in a susceptible strain.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
tetraspanin
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
TFL1 / HvCEN
Growth determination habit
Coding,
SNP
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Comadran J; Kilian B; Russell J ; et al. (2012)
Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and [...]
GP00001119
TFL1
P93003
Physiology
P135A
Hordeum vulgare
(species)
Hordeum vulgare
(species)
TFL1 / HvCEN
Hordeum vulgare
(species)
Published - Accepted by Curator
TFL1/FvTFL1
Flowering time
Seasonal growth
Cis-regulatory,
Unknown
Fragaria vesca
wild strawberry - (species)
Intraspecific
Linkage Mapping
Koskela EA; Mouhu K; Albani MC ; et al. (2012)
Mutation in TERMINAL FLOWER1 reverses the photoperiodic requirement for flowering in the wild strawb[...]
GP00001120
TFL1
P93003
Physiology
Physiology
unknown
Fragaria vesca
wild strawberry - (species)
Fragaria vesca
wild strawberry - (species)
TFL1/FvTFL1
Fragaria vesca
wild strawberry - (species)
Published - Accepted by Curator
TFL1/GmTFL1
Growth determination habit
Coding,
SNP
Glycine max
soybean - (species)
Domesticated
Linkage Mapping
Tian Z; Wang X; Lee R ; et al. (2010)
Artificial selection for determinate growth habit in soybean.
GP00001121
TFL1
P93003
Physiology
R62S
Glycine max
soybean - (species)
Glycine max
soybean - (species)
TFL1/GmTFL1
Glycine max
soybean - (species)
Published - Accepted by Curator
TFL1/GmTFL1
Growth determination habit
Coding,
SNP
Glycine max
soybean - (species)
Domesticated
Candidate Gene
Tian Z; Wang X; Lee R ; et al. (2010)
Artificial selection for determinate growth habit in soybean.
GP00001122
TFL1
P93003
Physiology
P113L
Glycine max
soybean - (species)
Glycine max
soybean - (species)
TFL1/GmTFL1
Glycine max
soybean - (species)
Published - Accepted by Curator
TFL1/GmTFL1
Growth determination habit
Coding,
SNP
Glycine max
soybean - (species)
Domesticated
Candidate Gene
Tian Z; Wang X; Lee R ; et al. (2010)
Artificial selection for determinate growth habit in soybean.
GP00001123
TFL1
P93003
Physiology
R130K
Glycine max
soybean - (species)
Glycine max
soybean - (species)
TFL1/GmTFL1
Glycine max
soybean - (species)
Published - Accepted by Curator
TFL1/GmTFL1
Growth determination habit
Coding,
SNP
Glycine max
soybean - (species)
Domesticated
Candidate Gene
Tian Z; Wang X; Lee R ; et al. (2010)
Artificial selection for determinate growth habit in soybean.
GP00001124
TFL1
P93003
Physiology
R166W
Glycine max
soybean - (species)
Glycine max
soybean - (species)
TFL1/GmTFL1
Glycine max
soybean - (species)
Published - Accepted by Curator
Thermo-tolerance 1 (TT1)
Temperature tolerance
Coding,
SNP
Oryza glaberrima
African rice - (species) D
Interspecific
Linkage Mapping
Li XM; Chao DY; Wu Y ; et al. (2015)
Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of Afri[...]
GP00001566
PAB1
Q10KF0
Physiology
p.R99H
Oryza sativa
rice - (species)
Oryza glaberrima
African rice - (species) D
Thermo-tolerance 1 (TT1)
Oryza glaberrima
African rice - (species)
Published - Accepted by Curator
thioester-containing protein 1
Pathogen resistance (Plasmodium; malaria parasite)
Coding,
Unknown
Anopheles coluzzii
(species)
Intraspecific
Linkage Mapping
Blandin SA; Wang-Sattler R; Lamacchia M ; et al. (2009)
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae.
1 Additional References
GP00001125
TEP-I
Q9GYW4
Physiology
coding change - exact causing mutation(s) unknown
Anopheles gambiae
African malaria mosquito - (species)
Anopheles coluzzii
(species)
thioester-containing protein 1
Anopheles coluzzii
(species)
Published - Accepted by Curator
Thyroid stimulating hormone receptor
Metabolism
Coding,
SNP
Gallus gallus
chicken - (species)
Domesticated
Association Mapping
Rubin CJ; Zody MC; Eriksson J ; et al. (2010)
Whole-genome resequencing reveals loci under selection during chicken domestication.
1 Additional References
GP00001127
TSHR
P16473
Physiology
Gly558Arg
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species)
Thyroid stimulating hormone receptor
Gallus gallus
chicken - (species)
Published - Accepted by Curator
thyroid-stimulating hormone-beta-2
Metabolic rate
Thyroid Hormone (plasma concentration)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Candidate Gene
Kitano J; Lema SC; Luckenbach JA ; et al. (2010)
Adaptive divergence in the thyroid hormone signaling pathway in the stickleback radiation.
GP00001288
tshba
B3DJU0
Physiology
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
thyroid-stimulating hormone-beta-2
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
TICAM1
Pathogen resistance (Trypanosoma)
Coding,
Unknown
Bos taurus
cattle - (species)
Domesticated
Linkage Mapping
Noyes H; Brass A; Obara I ; et al. (2011)
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypa[...]
GP00001128
TICAM1
Q8IUC6
Physiology
unknown
Bos
oxen, cattle - (genus)
Bos taurus
cattle - (species)
TICAM1
Bos taurus
cattle - (species)
Published - Accepted by Curator
timeless (tim)
Diapause
Locomotor activity
Coding,
Insertion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Tauber E; Zordan M; Sandrelli F ; et al. (2007)
Natural selection favors a newly derived timeless allele in Drosophila melanogaster.
1 Additional References
GP00001129
TIMELESS
Q9UNS1
Physiology
Behavior; Physiology
1bp insertion; allows production of longer protein from upstream start codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
timeless (tim)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
TLR6-TLR1-TLR10 cluster
Immune response
Unknown,
Complex Change
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Laayouni H; Oosting M; Luisi P ; et al. (2014)
Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-li[...]
1 Additional References
GP00001130
TLR1
Q15399
Physiology
Several Complex Haplotypes under positive selection - evidence on Adaptive Introgression from Neanderthal (2 haplotypes) and Denisova (1 haplotype)
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TLR6-TLR1-TLR10 cluster
Homo sapiens
human - (species)
Published - Accepted by Curator
TMEM154
Pathogen resistance (lentivirus)
Coding,
SNP
Ovis aries
sheep - (species) D
Intraspecific
Association Mapping
Heaton MP; Clawson ML; Chitko-Mckown CG ; et al. (2012)
Reduced lentivirus susceptibility in sheep with TMEM154 mutations.
GP00002242
TMEM154
Q6P9G4
Physiology
Mutation at conserved position associated to resistance in homozygous state
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
TMEM154
Ovis aries
sheep - (species)
Published - Accepted by Curator
TMEM263
Body size (dwarfism)
Coding,
SNP
N
Gallus gallus
chicken - (species) D
Domesticated
Linkage Mapping
Wu Z; Derks MFL; Dibbits B ; et al. (2018)
A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of Autosomal Dwarfism in Chi[...]
GP00002161
Physiology
g.53688583C>T c.433G>A p.Trp59∗ N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
TMEM263
Gallus gallus
chicken - (species)
Published - Accepted by Curator
TMPRSS6
Hematopoiesis (mean blood corpuscular hemoglobin)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001618
TMPRSS6
Q8IU80
Physiology
T>C at the associated SNP. Another SNP variant in strong LD p.V736A previously reported to influence iron homeostasis
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TMPRSS6
Homo sapiens
human - (species)
Published - Accepted by Curator
TPD3
Cell size
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Spor A; Kvitek DJ; Nidelet T ; et al. (2014)
Phenotypic and genotypic convergences are influenced by historical contingency and environment in ye[...]
GP00001499
TPD3
P31383
Physiology
C>T p.Q557* heterozygous nonsense mutation which may cause the larger cell size N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
TPD3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
tra-2
Fertility (self-fertility; hermaphrodite spermatogenesis)
Cis-regulatory,
Insertion
Caenorhabditis elegans
(species)
Interspecific
Candidate Gene
Kuwabara PE (1996)
Interspecies comparison reveals evolution of control regions in the nematode sex-determining gene tr[...]
2 Additional References
GP00001132
tra-2
P34709
Physiology
Tandem duplication of GLD-1 binding sites in 3'UTR; see also fog-2 entry
Caenorhabditis briggsae
(species)
Caenorhabditis elegans
(species)
tra-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
tra-3 calpain-like protease
Body size (temperature-size interaction)
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Kammenga JE; Doroszuk A; Riksen JA ; et al. (2007)
A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide pol[...]
GP00001133
tra-3
Q22036
Physiology
F96L
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
tra-3 calpain-like protease
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Tret1-like
Diapause
Cis-regulatory,
Unknown
Bombyx mori
domestic silkworm - (species) D
Domesticated
Association Mapping
Tong X; Han MJ; Lu K ; et al. (2022)
High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecologic[...]
GP00002402
Tret1-1
A1Z8N1
Physiology
The expression level of BmTret1-like in homozygotes (pnd/pnd) is significantly lower (p < 0.01, t test) than that in heterozygotes (pnd/+). CRISPR BmTret1-like knockout lines generate non-diapause eggs. A 747 bp deletion is present in the 3′-untranslated region (3′-UTR) of BmTret1-like in pnd homozygotes
Bombyx mori
domestic silkworm - (species)
Bombyx mori
domestic silkworm - (species) D
Tret1-like
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
TRIB2
Body fat distribution (pericardial)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001559
TRIB2
Q92519
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TRIB2
Homo sapiens
human - (species)
Published - Accepted by Curator
TRIM5alpha
Pathogen resistance (retroviruses)
Coding,
SNP
Cercopithecidae
Old World monkeys - (family)
Intraspecific
Candidate Gene
Newman RM; Hall L; Connole M ; et al. (2006)
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.
GP00001135
TRIM5
Q9C035
Physiology
several a.a. substitutions with retrovirus-specific activities; under balancing selection in several species
Cercopithecidae
Old World monkeys - (family)
Cercopithecidae
Old World monkeys - (family)
TRIM5alpha
Cercopithecidae
Old World monkeys - (family)
Published - Accepted by Curator
TRIM5alpha-CypA chimeric gene
Pathogen resistance (retroviruses)
Other,
Insertion
Aotus
night monkeys - (genus)
Intergeneric or Higher
Candidate Gene
Sayah DM; Sokolskaja E; Berthoux L ; et al. (2004)
Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.
1 Additional References
GP00001136
TRIM5
Q9C035
Physiology
LINE-mediated retrotransposition of the CyclophilinA gene between exons 7 and 8 of TRIM5alpha
Platyrrhini
New World monkeys - (parvorder)
Aotus
night monkeys - (genus)
TRIM5alpha-CypA chimeric gene
Aotus
night monkeys - (genus)
Published - Accepted by Curator
TRIM5alpha-CypA chimeric gene
Pathogen resistance (retroviruses)
Other,
Insertion
Macaca
macaques - (genus)
Intergeneric or Higher
Candidate Gene
Stoye JP; Yap MW (2008)
Chance favors a prepared genome.
GP00001137
TRIM5
Q9C035
Physiology
LINE-mediated retrotransposition of the CyclophilinA gene into 3'UTR (exon 8) of TRIM5alpha
Cercopithecidae
Old World monkeys - (family)
Macaca
macaques - (genus)
TRIM5alpha-CypA chimeric gene
Macaca
macaques - (genus)
Published - Accepted by Curator
TRK1
Salt tolerance (ammonium)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Domesticated
Linkage Mapping
Reisser C; Dick C; Kruglyak L ; et al. (2013)
Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case.
GP00001139
NTRK1
P04629
Physiology
Candidate a.a substitutions in K12 : C1143S; H551P; E1190G; Q1227K
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
TRK1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
tryptophan phenylalanine hydroxylase
Enzymatic activity
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Ruiz-Vázquez P; Silva FJ (1999)
Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the in[...]
GP00002003
Hn
P17276
Physiology
insertion of the transposable element B104/roo in the exon 3 of the Phenylalanine hydroxylase gene. Its presence alters the Phenylalanine hydroxylase splicing pattern; producing at least two aberrant mRNAs which contain part of the B104 sequence interrupting the coding region. This aberrant splicing is provoked by the use of a cryptic donor site encoded by the B104 3' long terminal repeat in combination with either the gene intron 3 acceptor site or a novel acceptor site generated by the target duplication caused by transposition. One of them; referred as mRNA type 1; encodes a truncated protein that could be predictably non-functional. In mRNA type 2; in spite of a 42 nt insertion; the Phenylalanine hydroxylase reading frame is not altered and it would encode for a protein with 14 extra amino acids which would be able to account for the low enzyme activity detected in this mutant.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
tryptophan phenylalanine hydroxylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
TSA2
Xenobiotic resistance (hydrogen peroxide)
Gene Amplification,
Complex Change
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Linkage Mapping
Linder RA; Greco JP; Seidl F ; et al. (2017)
The Stress-Inducible Peroxidase TSA2 Underlies a Conditionally Beneficial Chromosomal Duplication in[...]
GP00001831
TSA2
Q04120
Physiology
Chromosome 4 whole duplication. Using a genetic mapping strategy that involves systematically deleting segments of a duplicated chromosome; the authors show that the chromosome IV’s duplication effect is largely due to the generation of a second copy of the stress-inducible cytoplasmic thioredoxin peroxidase TSA2.
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
TSA2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
SNP
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Elleder D; Melder DC; Trejbalova K ; et al. (2004)
Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]
GP00002256
tva
Q6JBY7
Physiology
c.120C>G p.C40W
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Insertion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Elleder D; Melder DC; Trejbalova K ; et al. (2004)
Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]
GP00002257
tva
Q6JBY7
Physiology
c.48insCTCG N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Chen W; Liu Y; Li H ; et al. (2015)
Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]
GP00002258
tva
Q6JBY7
Physiology
c.502_511delCGCTCACCCC N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Chen W; Liu Y; Li H ; et al. (2015)
Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]
GP00002259
tva
Q6JBY7
Physiology
c.502_516delCGCTCACCCCGCCCC N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Reinišová M; Plachý J; Trejbalová K ; et al. (2012)
Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]
GP00002260
tva
Q6JBY7
Physiology
c.506-515del10 ; splicing N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Reinišová M; Plachý J; Trejbalová K ; et al. (2012)
Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]
GP00002261
tva
Q6JBY7
Physiology
c.507-511del5 ; splicing N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
two pore channel
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001433
TPC1
Q94KI8
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
two pore channel
Arabidopsis arenosa
(species)
Published - Accepted by Curator
tyrosyl-tRNA synthetase (mt-TyrRS)
Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013)
An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...]
1 Additional References
GP00001972
TyrRS-m
Q9W107
Physiology
C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
tyrosyl-tRNA synthetase (mt-TyrRS)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
UBE2E2
Body fat distribution (visceral/subcutaneous ratio)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001553
UBE2E2
Q96LR5
Physiology
T>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
UBE2E2
Homo sapiens
human - (species)
Published - Accepted by Curator
Ubiquitin conjugating enzyme E2H (Ubc-E2H)
Pathogen resistance (Drosophila C virus & cricket paralysis virus)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Experimental Evolution
Association Mapping
Martins NE; Faria VG; Nolte V ; et al. (2014)
Host adaptation to viruses relies on few genes with different cross-resistance properties.
GP00001480
UbcE2H
Q7JW03
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Ubiquitin conjugating enzyme E2H (Ubc-E2H)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
UDP-glycosyltransferase 89A2
Plant secondary metabolites (xylosides vs. glucosides ratio)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Li X; Svedin E; Mo H ; et al. (2014)
Exploiting natural variation of secondary metabolism identifies a gene controlling the glycosylation[...]
GP00001278
UGT89A2
Q9LZD8
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
UDP-glycosyltransferase 89A2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
UGT86 (Bm-UGT10286)
Coloration (cocoon)
Gene Loss,
Deletion
N
Bombyx mori
domestic silkworm - (species) D
Domesticated
Linkage Mapping
Daimon T; Hirayama C; Kanai M ; et al. (2010)
The silkworm Green b locus encodes a quercetin 5-O-glucosyltransferase that produces green cocoons w[...]
1 Additional References
GP00001160
Bm-UGT10286
D6RUU6
Physiology
38kb gene deletion N
Bombyx
(genus)
Bombyx mori
domestic silkworm - (species) D
UGT86 (Bm-UGT10286)
Bombyx mori
domestic silkworm - (species)
Published - Accepted by Curator
Ugt86Dd
Xenobiotic resistance (nicotine ; larval stage)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Marriage TN; King EG; Long AD ; et al. (2014)
Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cr[...]
1 Additional References
GP00001406
Ugt86Dd
Q9VGT8
Physiology
22-bp frameshift deletion in Ugt86Dd - CRISPR-induced deletions in Ugt86Dd lead to a large reduction in resistance N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Ugt86Dd
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Uncoupling protein 1 (UCP1)
Thermoregulation (brown adipose tissue)
Coding,
Deletion
N
Sus
(genus) D
Intergeneric or Higher
Candidate Gene
Berg F; Gustafson U; Andersson L (2006)
The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor[...]
GP00001162
Ucp1
P12242
Physiology
deletion of exons 3 to 5 N
Mammalia
mammals - (class)
Sus
(genus) D
Uncoupling protein 1 (UCP1)
Sus
(genus)
Published - Accepted by Curator
Vacuolar transporter chaperone 1
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001290
VTC1
P40046
Physiology
G>T (Asp > Tyr) @ position 289
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 1
Metal tolerance (copper)
Coding,
Indel
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001291
VTC1
P40046
Physiology
Pro > His+frameshift @ position 13 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 1
Metal tolerance (copper)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001292
VTC1
P40046
Physiology
C>A (Ser > Stop) @ position 104 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001293
VTC4
P47075
Physiology
C>T (Trp > Stop) @ position 800 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001294
VTC4
P47075
Physiology
C>A (Glu > Stop) @ position 226 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
Indel
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001295
VTC4
P47075
Physiology
Phe > Ser+frameshift @ position 380 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001296
VTC4
P47075
Physiology
A>G (Tyr > His) @ position 1075
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001297
VTC4
P47075
Physiology
C>T (Trp > Stop) @ position 1320 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001298
VTC4
P47075
Physiology
T>A (Arg > Stop) @ position 757 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Vacuolar transporter chaperone 4
Metal tolerance (copper)
Coding,
SNP
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Experimental Evolution
Association Mapping
Gerstein AC; Ono J; Lo DS ; et al. (2015)
Too much of a good thing: the unique and repeated paths toward copper adaptation.
GP00001299
VTC4
P47075
Physiology
C>A (Glu > Stop) @ position 1153 N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Vacuolar transporter chaperone 4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
VGLL3 (vestigial-like family member 3 gene )
Age of sexual maturity
Unknown,
Unknown
Salmo salar
Atlantic salmon - (species)
Intraspecific
Association Mapping
Barson NJ; Aykanat T; Hindar K ; et al. (2015)
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon.
1 Additional References
GP00001167
VGLL3
A8MV65
Physiology
candidate amino-acid substitutions
Salmo salar
Atlantic salmon - (species)
Salmo salar
Atlantic salmon - (species)
VGLL3 (vestigial-like family member 3 gene )
Salmo salar
Atlantic salmon - (species)
Published - Accepted by Curator
VIN3
Flowering time
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ågren J; Oakley CG; Lundemo S ; et al. (2017)
Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]
GP00001538
VIN3
Q9FIE3
Physiology
4 nonsynonymous substitutions and a 3 bp deletion
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
VIN3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Linkage Mapping
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001168
VKORC1
Q9BQB6
Physiology
R98W
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001169
VKORC1
Q9BQB6
Physiology
V29L
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001170
VKORC1
Q9BQB6
Physiology
V45A
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001171
VKORC1
Q9BQB6
Physiology
R58G
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001172
VKORC1
Q9BQB6
Physiology
L128S
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Vkorc1
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001173
VKORC1
Q9BQB6
Physiology
Y139C
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Vkorc1
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Mus spretus
western wild mouse - (species)
Intraspecific
Candidate Gene
Song Y; Endepols S; Klemann N ; et al. (2011)
Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world [...]
GP00001174
VKORC1
Q9BQB6
Physiology
Several candidate coding changes
Mus musculus
house mouse - (species)
Mus spretus
western wild mouse - (species)
Vkorc1
Mus spretus
western wild mouse - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Linkage Mapping
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
GP00001175
VKORC1
Q9BQB6
Physiology
Y139C
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001176
VKORC1
Q9BQB6
Physiology
S56P
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001177
VKORC1
Q9BQB6
Physiology
L128S
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001178
VKORC1
Q9BQB6
Physiology
L128Q
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001179
VKORC1
Q9BQB6
Physiology
L120Q
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001180
VKORC1
Q9BQB6
Physiology
Y139S
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Lasseur R; Longin-Sauvageon C; Videmann B ; et al. (2005)
Warfarin resistance in a French strain of rats.
1 Additional References
GP00001181
VKORC1
Q9BQB6
Physiology
Y139F
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Tanaka KD; Kawai YK; Ikenaka Y ; et al. (2013)
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.
GP00001182
VKORC1
Q9BQB6
Physiology
R33P
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
VPS13A
Latitudinal adaptation
Coding,
SNP
Sus scrofa
pig - (species) D
Domesticated
Association Mapping
Ai H; Fang X; Yang B ; et al. (2015)
Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequen[...]
GP00001571
VPS13A
F1SIL5
Physiology
two nonsynonymous substitutions V>G and F>Y - whether both or only one affects the phenotype is unknown
Sus scrofa
pig - (species)
Sus scrofa
pig - (species) D
VPS13A
Sus scrofa
pig - (species)
Published - Accepted by Curator
VRN1
Flowering time
Cis-regulatory,
Indel
Lolium perenne
(species)
Intraspecific
Candidate Gene
Asp T; Byrne S; Gundlach H ; et al. (2011)
Comparative sequence analysis of VRN1 alleles of Lolium perenne with the co-linear regions in barley[...]
GP00001183
VRN1
Q8L3W1
Physiology
8.6kb indel in first intron
Lolium perenne
(species)
Lolium perenne
(species)
VRN1
Lolium perenne
(species)
Published - Accepted by Curator
VRN1
Flowering time
Cis-regulatory,
Deletion
Triticum aestivum
bread wheat - (species) D
Domesticated
Linkage Mapping
Trevaskis B; Bagnall DJ; Ellis MH ; et al. (2003)
MADS box genes control vernalization-induced flowering in cereals.
GP00001184
VRN1
Q8L3W1
Physiology
Deletion
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species) D
VRN1
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
VRN1
Flowering time
Cis-regulatory,
Unknown
Triticum monococcum
(species)
Domesticated
Linkage Mapping
Yan L; Loukoianov A; Tranquilli G ; et al. (2003)
Positional cloning of the wheat vernalization gene VRN1.
GP00001185
VRN1
Q8L3W1
Physiology
Not identified
Triticum monococcum
(species)
Triticum monococcum
(species)
VRN1
Triticum monococcum
(species)
Published - Accepted by Curator
VRN1
Flowering time
Cis-regulatory,
Insertion
Triticum turgidum
(species) D
Domesticated
Linkage Mapping
Chu CG; Tan CT; Yu GT ; et al. (2011)
A Novel Retrotransposon Inserted in the Dominant Vrn-B1 Allele Confers Spring Growth Habit in Tetrap[...]
GP00002105
VRN1
Q8L3W1
Physiology
5463-bp insertion in the 5'-UTR region of the Vrn-B1 allele. This insertion is a novel retrotransposon (designated as retrotrans_VRN), which is flanked by a 5-bp target site duplication and contains primer binding site and polypurine tract motifs; a 325-bp long terminal repeat and an open reading frame encoding 1231 amino acids. The insertion of retrotrans_VRN results in expression of Vrn-B1 without vernalization.
Triticum turgidum
(species)
Triticum turgidum
(species) D
VRN1
Triticum turgidum
(species)
Published - Accepted by Curator
VRN2
Flowering time
Gene Loss,
Deletion
N
Hordeum vulgare
(species)
Domesticated
Linkage Mapping
Yan L; Loukoianov A; Blechl A ; et al. (2004)
The wheat VRN2 gene is a flowering repressor down-regulated by vernalization.
GP00001186
VRN2
Q8W5B1
Physiology
Large deletion N
Hordeum vulgare
(species)
Hordeum vulgare
(species)
VRN2
Hordeum vulgare
(species)
Published - Accepted by Curator
VRN2
Flowering time
Coding,
SNP
Triticum monococcum
(species)
Domesticated
Linkage Mapping
Yan L; Loukoianov A; Blechl A ; et al. (2004)
The wheat VRN2 gene is a flowering repressor down-regulated by vernalization.
GP00001187
VRN2
Q8W5B1
Physiology
R35W; R is conserved in all of the ZCCT proteins and in all of the CO-like proteins from Arabidopsis; rice; and barley
Triticum monococcum
(species)
Triticum monococcum
(species)
VRN2
Triticum monococcum
(species)
Published - Accepted by Curator
VRN2
Flowering time
Gene Loss,
Deletion
N
Triticum monococcum
(species) D
Domesticated
Candidate Gene
Yan L; Loukoianov A; Blechl A ; et al. (2004)
The wheat VRN2 gene is a flowering repressor down-regulated by vernalization.
GP00001188
VRN2
Q8W5B1
Physiology
Large deletion; complete deletion of ZCCT1 and ZCCT2=VRN2 genes N
Triticum monococcum
(species)
Triticum monococcum
(species) D
VRN2
Triticum monococcum
(species)
Published - Accepted by Curator
VTE3(1)
Vitamin-E synthesis
Cis-regulatory,
Epigenetic Change
Solanum lycopersicum
tomato - (species)
Domesticated
Linkage Mapping
Quadrana L; Almeida J; Asís R ; et al. (2014)
Natural occurring epialleles determine vitamin E accumulation in tomato fruits.
GP00001684
VTE3
Q9LY74
Physiology
Solanum lycopersicum
tomato - (species)
Solanum lycopersicum
tomato - (species)
VTE3(1)
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Cis-regulatory,
Deletion
Hordeum vulgare
(species) D
Domesticated
Linkage Mapping
Domon E; Fuijita M; Ishikawa N (2002)
The insertion/deletion polymorphisms in the waxy gene of barley genetic resources from East Asia.
GP00001197
waxy
Q8L699
Physiology
403-bp deletion spanning from position –129 bp to position +274 relative to the deduced starting point of transcription in the barley waxy gene and
Hordeum vulgare
(species)
Hordeum vulgare
(species) D
Waxy /GBSS
Hordeum vulgare
(species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Cis-regulatory,
Insertion
Setaria italica
foxtail millet - (species) D
Domesticated
Candidate Gene
Kawase M; Fukunaga K; Kato K (2005)
Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]
GP00001198
waxy
Q8L699
Physiology
Transposon insertion TSI-11 (Intron 12)
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Waxy /GBSS
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Cis-regulatory,
Insertion
Setaria italica
foxtail millet - (species) D
Domesticated
Linkage Mapping
Kawase M; Fukunaga K; Kato K (2005)
Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]
GP00001199
waxy
Q8L699
Physiology
Transposon insertion TSI-2 (intron 1)
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Waxy /GBSS
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Cis-regulatory,
Insertion
Setaria italica
foxtail millet - (species) D
Domesticated
Candidate Gene
Kawase M; Fukunaga K; Kato K (2005)
Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]
GP00001200
waxy
Q8L699
Physiology
Transposon insertion TSI-10 (Intron 12)
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Waxy /GBSS
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Coding,
Insertion
N
Setaria italica
foxtail millet - (species) D
Domesticated
Candidate Gene
Kawase M; Fukunaga K; Kato K (2005)
Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]
GP00001201
waxy
Q8L699
Physiology
Transposon insertion TS1-7 (Exon 3) N
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Waxy /GBSS
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Coding,
Insertion
N
Setaria italica
foxtail millet - (species) D
Domesticated
Candidate Gene
Kawase M; Fukunaga K; Kato K (2005)
Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]
GP00001202
waxy
Q8L699
Physiology
Transposon insertion TS1-9 (Exon 10) N
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Waxy /GBSS
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content
Cis-regulatory,
Deletion
Setaria italica
foxtail millet - (species) D
Domesticated
Candidate Gene
Kawase M; Fukunaga K; Kato K (2005)
Diverse origins of waxy foxtail millet crops in East and Southeast Asia mediated by multiple transpo[...]
GP00001203
waxy
Q8L699
Physiology
2.4kb deletion (intron 1)
Setaria italica
foxtail millet - (species)
Setaria italica
foxtail millet - (species) D
Waxy /GBSS
Setaria italica
foxtail millet - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content (glutinous rice)
Coding,
SNP
Oryza sativa
rice - (species)
Domesticated
Linkage Mapping
Wang ZY; Zheng FQ; Shen GZ ; et al. (1995)
The amylose content in rice endosperm is related to the post-transcriptional regulation of the waxy [...]
3 Additional References
GP00001204
waxy
Q8L699
Physiology
substitution G->T in the 5' splice site of intron 1
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Waxy /GBSS
Oryza sativa
rice - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content (glutinous rice)
Coding,
Insertion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Hori Y; Fujimoto R; Sato Y ; et al. (2007)
A novel wx mutation caused by insertion of a retrotransposon-like sequence in a glutinous cultivar o[...]
GP00002069
waxy
Q8L699
Physiology
23-bp duplication in the second exon which causes loss of the function of granule-bound starch synthase (GBSS) encoded by the Wx gene N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Waxy /GBSS
Oryza sativa
rice - (species)
Published - Accepted by Curator
Waxy /GBSS
Amylose content (glutinous rice)
Coding,
Insertion
N
Oryza sativa
rice - (species) D
Domesticated
Candidate Gene
Hori Y; Fujimoto R; Sato Y ; et al. (2007)
A novel wx mutation caused by insertion of a retrotransposon-like sequence in a glutinous cultivar o[...]
GP00002070
waxy
Q8L699
Physiology
insertion of 7764 bp in the ninth exon of the wx gene. Transcripts of the 'Oragamochi' wx allele are about 1-kb shorter and the deduced amino acid sequence of the transcript lacks a motif important for GBSS. The 7,764-bp insertion is a retrotransposon-like sequence with long terminal repeats; a primer binding site and a polypurine tract N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species) D
Waxy /GBSS
Oryza sativa
rice - (species)
Published - Accepted by Curator
WDR66
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001604
WDR66
Q8TBY9
Physiology
A>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
WDR66
Homo sapiens
human - (species)
Published - Accepted by Curator
WRR4
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Borhan MH; Gunn N; Cooper A ; et al. (2008)
WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis t[...]
GP00001215
ADR2
Q9C7X0
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
WRR4
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Xa1
Pathogen resistance
Unknown,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Yoshimura S; Yamanouchi U; Katayose Y ; et al. (1998)
Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation.
GP00001216
XA1
A0A0H5AGW3
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Xa1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Xa21
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Song WY; Wang GL; Chen LL ; et al. (1995)
A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21.
GP00001217
Xa21
A0PIA3
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Xa21
Oryza sativa
rice - (species)
Published - Accepted by Curator
Xa26
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Sun X; Cao Y; Yang Z ; et al. (2004)
Xa26, a gene conferring resistance to Xanthomonas oryzae pv. oryzae in rice, encodes an LRR receptor[...]
GP00001218
Xa26
Q00KZ8
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Xa26
Oryza sativa
rice - (species)
Published - Accepted by Curator
Xmrk
Hybrid incompatibility (melanoma)
Unknown,
Unknown
Xiphophorus hellerii
green swordtail - (species)
Interspecific
Linkage Mapping
Adam D; Dimitrijevic N; Schartl M (1993)
Tumor suppression in Xiphophorus by an accidentally acquired promoter.
1 Additional References
GP00001219
xmrk
P13388
Physiology
Various
Xiphophorus maculatus
southern platyfish - (species)
Xiphophorus hellerii
green swordtail - (species)
Xmrk
Xiphophorus hellerii
green swordtail - (species)
Published - Accepted by Curator
Xmrk
Hybrid incompatibility (melanoma)
Gene Loss,
Deletion
N
Xiphophorus malinche
highland swordtail - (species) D
Interspecific
Association Mapping
Powell DL; García-Olazábal M; Keegan M ; et al. (2020)
Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.
GP00002137
xmrk
P13388
Physiology
Loss of Xmrk in several Xiphophorus species N
Xiphophorus birchmanni
sheepshead swordtail - (species)
Xiphophorus malinche
highland swordtail - (species) D
Xmrk
Xiphophorus malinche
highland swordtail - (species)
Published - Accepted by Curator
zfl2
Flowering time
Coding,
Deletion
Zea mays
(species) D
Domesticated
Linkage Mapping
Buckler ES; Holland JB; Bradbury PJ ; et al. (2009)
The genetic architecture of maize flowering time.
GP00001226
zfl2
Q5Q1L6
Physiology
16a.a. deletion
Zea mays
(species)
Zea mays
(species) D
zfl2
Zea mays
(species)
Published - Accepted by Curator
ZmCCT
Flowering time
Cis-regulatory,
Insertion
Zea mays
(species) D
Domesticated
Linkage Mapping
Ducrocq S; Giauffret C; Madur D ; et al. (2009)
Fine mapping and haplotype structure analysis of a major flowering time quantitative trait locus on [...]
2 Additional References
GP00001227
GHD7
E5RQA1
Physiology
insertion of a CACTA-like transposon into the promoter of ZmCCT. This insertion suppresses ZmCCT expression through methylation and reduces maize sensitivity to photoperiod.
Zea mays
(species)
Zea mays
(species) D
ZmCCT
Zea mays
(species)
Published - Accepted by Curator
Zmr1
Xenobiotic resistance (fungicide)
Melanin content
2 Mutations:
Cis-regulatory
Zymoseptoria tritici
(species)
Intraspecific
Linkage Mapping
Krishnan P; Meile L; Plissonneau C ; et al. (2018)
Transposable element insertions shape gene regulation and melanin production in a fungal pathogen of[...]
GP00001715
CMR1
Q06F33
Physiology
Physiology
2 mutations
Zymoseptoria tritici
(species)
Zymoseptoria tritici
(species)
Zmr1
Zymoseptoria tritici
(species)
Published - Accepted by Curator
ZmVPP1
Drought tolerance
Cis-regulatory,
Insertion
Zea mays
(species)
Intraspecific
Association Mapping
Wang X; Wang H; Liu S ; et al. (2016)
Genetic variation in ZmVPP1 contributes to drought tolerance in maize seedlings.
GP00001567
GRMZM2G170927
A0A172DSU8
Physiology
A 366-bp insertion in the promoter containing 3 MYB cis elements confers drought-inducible expression of ZmVPP1 in drought-tolerant genotypes
Zea mays
(species)
Zea mays
(species)
ZmVPP1
Zea mays
(species)
Published - Accepted by Curator
Zygotic hybrid rescue
F1 lethality (female-limited)
Unknown,
Unknown
Drosophila simulans
(species)
Interspecific
Linkage Mapping
Ferree PM; Barbash DA (2009)
Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality i[...]
GP00001228
Physiology
Heterochromatin incompatibilitity
Drosophila melanogaster
fruit fly - (species)
Drosophila simulans
(species)
Zygotic hybrid rescue
Drosophila simulans
(species)
Published - Accepted by Curator
β-adrenergic octopamine receptor gene (AOR)
Xenobiotic resistance (amitraz)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Association Mapping
Corley SW; Jonsson NN; Piper EK ; et al. (2013)
Mutation in the RmβAOR gene is associated with amitraz resistance in the cattle tick Rhipicephalus m[...]
1 Additional References
GP00002396
Oct-TyrR
P22270
Physiology
L64I
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
β-adrenergic octopamine receptor gene (AOR)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator